No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
820 |
4. Check minimum number of eventsNone |
820 |
5. Include endpointsNone |
820 |
6. Filter based on genotype QC (FinnGen only) |
820 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- First used in FinnGen datafreeze
- DF6
Similar endpoints
↥List of similar endpoints to
Oral lichen ruber planus
based on the number of shared cases.
Similar with more cases:
- Oral lichen ruber planus, including avohilmo
- Other diseases of lip and oral mucosa
- Lichen ruber planus, wide definition including periferal and oral lichen planus
- Diseases of oral cavity, salivary glands and jaws
- Gastrointestinal diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3550 | 2602 | 940 |
| Only index persons | 3534 | 2596 | 938 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.03 |
| Only index persons | 0.08 | 0.10 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 63.69 | 64.61 | 61.30 |
| Only index persons | 63.76 | 64.64 | 61.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 820 | 636 | 184 |
| Unadjusted period prevalence (%) | 0.19 | 0.22 | 0.08 |
| Median age at first event (years) | 64.96 | 64.84 | 65.35 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 718
- Matched controls
- 7179
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
+∞
323.0
718
34
EKA10
NOMESCO Finland
Biopsy of cheek
77.1
274.2
305
68
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
37.1
197.6
257
106
L43.8
ICD-10 Finland
Other lichen planus
46.7
169.8
208
62
SBA00
NOMESCO Finland
Microbiological examinations
37.0
165.9
215
82
SAA03
NOMESCO Finland
Extended examination of mouth
9.2
153.7
559
1984
L43.9
ICD-10 Finland
Lichen planus, unspecified
37.3
149.5
193
70
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
25.3
104.8
150
74
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.1
91.0
440
1691
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
25.9
89.7
127
59
D07AC01
ATC
betamethasone; topical
5.0
87.2
439
1731
WZB00
NOMESCO Finland
Telephone receipt or other advice
5.0
85.4
391
1386
ECA20
NOMESCO Finland
Biopsy of gingiva
46.7
82.8
101
25
D07AD01
ATC
clobetasol; topical
5.8
81.9
283
723
K13.78
ICD-10 Finland
Other change in the oral mucosa
21.2
76.3
115
64
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
11.4
71.8
142
152
A07AA02
ATC
nystatin; oral
8.6
68.1
160
232
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
10.7
64.8
132
148
K13.29
ICD-10 Finland
Indefinite leukoplakia
33.8
58.2
76
25
L43
ICD-10 Finland
Lichen planus
28.1
56.9
78
31
L43.0
ICD-10 Finland
Hypertrophic lichen planus
72.5
53.1
60
9
SAA04
NOMESCO Finland
Special inverstigation of mouth
6.8
38.8
103
172
SAA01
NOMESCO Finland
Simple examination of mouth
3.2
37.4
584
4139
L43.3
ICD-10 Finland
Subacute (active) lichen planus
43.6
36.7
45
11
B37.08
ICD-10 Finland
Other candidal stomatitis
26.2
35.4
49
20
SAA02
NOMESCO Finland
Basic examination of mouth
2.9
34.9
537
3660
SXA10
NOMESCO Finland
Epithel biopsy of mouth
20.7
34.9
52
27
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
2.7
34.3
361
1959
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
5.5
31.7
99
202
B37.03
ICD-10 Finland
Chronic atrophic candida infection in the mouth
55.6
31.6
37
7
TEA00
NOMESCO Finland
Biopsy of lip
22.8
28.6
41
19
D20
ICPC
Mouth/tongue/lip symptom/complaint
6.0
27.3
79
146
XQ802
NOMESCO Finland
Epicutan test
5.7
27.3
82
159
WX110
NOMESCO Finland
Local anesthesy
2.6
26.9
552
4057
SBB10
NOMESCO Finland
Teeth copy
5.2
26.6
86
182
R01AD11
ATC
triamcinolone; nasal
3.7
26.5
126
388
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
7.6
25.1
60
85
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
2.5
23.1
231
1150
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
37.7
23.1
29
8
J02AC01
ATC
fluconazole; systemic
2.2
22.5
382
2451
K13.20
ICD-10 Finland
Idiopathic leukoplakia
28.4
22.4
30
11
A01AC01
ATC
triamcinolone; local oral
7.9
22.0
51
69
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
30.1
22.0
29
10
D07AB02
ATC
hydrocortisone butyrate; topical
2.3
21.9
254
1360
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.2
20.9
345
2158
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.0
20.0
84
230
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
6.1
19.1
53
93
K12.10
ICD-10 Finland
Stomatitis NOS
35.4
19.0
24
7
SFA10
NOMESCO Finland
Fillning on one surface of tooth
2.0
18.5
420
2942
K13.22
ICD-10 Finland
Erythroplakia of oral epithelium, including tongue
33.9
18.1
23
7
E0000UV
ATC
NA
2.0
18.0
325
2071
D05BB02
ATC
acitretin; oral
8.2
18.0
40
51
A01AB09
ATC
miconazole; local oral
3.0
17.5
107
391
K12.18
ICD-10 Finland
Other forms of stomatitis
15.3
17.3
28
19
K05.30
ICD-10 Finland
Periodontitis complex
2.7
16.6
129
547
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
5.3
16.4
51
103
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.9
16.4
437
3187
K02.1
ICD-10 Finland
Caries of dentine
1.9
16.2
426
3085
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
15.8
256
1539
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.8
15.5
107
422
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.7
15.4
111
450
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
9.5
15.3
31
34
SDA02
NOMESCO Finland
Parodonthologic therapy
2.0
15.3
274
1710
ZXD31
NOMESCO Finland
Major difficulties in performing procedure
4.9
15.2
50
108
A01AB04
ATC
amphotericin B; local oral
3.9
15.2
63
171
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
20.6
15.2
22
11
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.3
15.0
158
786
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.1
14.8
198
1097
C03.1
ICD-10 Finland
Malignant neoplasm: Lower gum
81.8
14.6
16
*
SXC03
NOMESCO Finland
Other oral or dental procedure
11.7
14.4
26
23
SXC05
NOMESCO Finland
Other oral or dental procedure
3.5
14.2
67
203
8070/3-C02.1
ICD-O-3
Squamous cell carcinoma, NOS, of border of tongue
43.4
14.2
17
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.8
14.1
94
363
Z01.2
ICD-10 Finland
Dental examination
1.9
13.7
323
2198
L28.0
ICD-10 Finland
Lichen simplex chronicus
8.6
13.6
29
35
EDB00
NOMESCO Finland
Partial excision of mandible
76.6
13.6
15
*
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.8
13.6
427
3198
ULA02
NOMESCO Finland
Kolposcopy
2.7
13.5
99
402
EHA10
NOMESCO Finland
Biopsy of palate
18.7
13.4
20
11
N77.8*L43.9
ICD-10 Finland
Vulvovaginal ulceration and inflammation caused by lichen ruber planus
26.3
13.4
18
7
EJ2S1
NOMESCO Finland
Photography of oral mucosa
26.3
13.4
18
7
D07AC13
ATC
mometasone; topical
1.9
13.4
233
1423
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.8
13.4
92
361
L43.1
ICD-10 Finland
Bullous lichen planus
40.9
13.2
16
*
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.8
13.0
86
328
H02AB06
ATC
prednisolone; systemic
1.8
12.8
358
2558
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.9
12.2
209
1258
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.9
12.2
206
1236
D82
ICPC
Teeth/gum disease
1.8
12.1
261
1704
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
2.4
11.6
105
479
K11.71
ICD-10 Finland
Xerostomy (dry mouth)
8.3
11.6
25
31
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
15.3
11.3
18
12
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
4.6
11.0
37
83
R13
ICD-10 Finland
Dysphagia
3.0
10.9
62
216
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
3.0
10.8
63
224
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.7
10.4
343
2520
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.1
10.4
59
204
L44.3
ICD-10 Finland
Lichen ruber moniliformis
+∞
10.4
10
*
EJ2S1
SPAT
NA
+∞
10.4
10
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
10.3
167
980
SBA10
NOMESCO Finland
Measurement of excretion of saliva
7.6
10.2
23
31
SXA20
NOMESCO Finland
Local application of medicine to mouth
3.1
10.2
57
195
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.7
10.1
355
2647
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.7
10.1
333
2439
R01AD09
ATC
mometasone; nasal
1.7
10.1
341
2514
B37.01
ICD-10 Finland
Acute athrophy candidal stomatitis
26.4
9.8
13
5
PJD81
NOMESCO Finland
Excision of lymph nodes from upper part of neck
20.4
9.8
14
7
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.8
9.8
194
1215
LEB00
NOMESCO Finland
Biopsy of vagina
4.7
9.7
32
71
TLE00
NOMESCO Finland
Dilatation of vagina
55.7
9.7
11
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
10.2
9.6
18
18
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.2
9.5
103
513
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
9.4
332
2462
K05.31
ICD-10 Finland
Periodontitis pronounced
2.3
9.3
90
422
A02BC05
ATC
esomeprazole; systemic
1.6
9.3
323
2384
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
2.5
9.2
75
326
K03.66
ICD-10 Finland
Tooth plaque
2.8
9.2
58
218
EBB10
NOMESCO Finland
Insertion of dental implant
6.4
9.1
23
37
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
9.1
199
1280
R06AX27
ATC
desloratadine; oral
1.7
9.1
206
1342
EBA00
NOMESCO Finland
Extraction of tooth
1.7
9.1
237
1611
SDA12
NOMESCO Finland
Treatment of complicated periodontal disease
6.6
9.0
22
34
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
9.0
257
1793
N89.5
ICD-10 Finland
Stricture and atresia of vagina
18.9
9.0
13
7
K13.03
ICD-10 Finland
Keilit UNS
24.3
8.9
12
5
E000001
ATC
NA
1.9
8.9
158
948
K11.70
ICD-10 Finland
Hypoptyalism
12.7
8.9
15
12
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.0
8.8
112
596
EKB00
NOMESCO Finland
Excision of lesion of cheek
14.2
8.7
14
10
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
50.6
8.7
10
*
WZA90
NOMESCO Finland
Other doctors statement
1.8
8.6
174
1094
EMAK
NOMESCO Finland
NA
3.7
8.5
36
102
8070/3-C06.0
ICD-O-3
Squamous cell carcinoma, NOS, of cheeck mucosa
+∞
8.3
8
*
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.7
8.2
55
214
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
4.0
8.1
31
80
H03AA01
ATC
levothyroxine sodium; systemic
1.7
8.1
197
1304
SPA02
NOMESCO Finland
Preparation for dental prosthetics
4.2
8.1
29
71
M01AH05
ATC
etoricoxib; oral
1.6
8.0
434
3533
J01DB01
ATC
cefalexin; oral
1.7
8.0
571
4995
P01AB01
ATC
metronidazole; oral, rectal
1.6
7.9
310
2329
SPA41
NOMESCO Finland
Precision impression for fixed dental prosthesis
6.2
7.9
20
33
P01BA02
ATC
hydroxychloroquine; oral
2.2
7.9
83
407
K13.2
ICD-10 Finland
Leukoplakia and other disturbances of oral epithelium, including tongue
15.2
7.7
12
8
K03.64
ICD-10 Finland
Dental calculus supragingival
1.7
7.7
199
1337
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.6
7.6
299
2240
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.5
7.6
58
241
R01AD12
ATC
fluticasone furoate; nasal
1.6
7.6
218
1507
EJB40
NOMESCO Finland
Hemiglossectomy
25.3
7.6
10
*
D83
ICPC
Mouth/tongue/lip disease
9.0
7.6
15
17
A07EA02
ATC
hydrocortisone; rectal
4.7
7.6
24
52
SFA00
NOMESCO Finland
Small filling
2.0
7.5
101
548
ECA30
NOMESCO Finland
Excision of lesion of gingiva
6.1
7.4
19
32
N03AX09
ATC
lamotrigine; oral
3.1
7.4
39
132
ZYC01
NOMESCO Finland
Remote contact by phone
3.2
7.3
37
121
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.1
7.3
83
422
D06BX01
ATC
metronidazole; topical
2.1
7.2
87
452
XQ800
NOMESCO Finland
Prick test
2.3
7.2
64
288
WX105
SPAT
NA
30.3
7.2
9
*
C03.0
ICD-10 Finland
Malignant neoplasm: Upper gum
30.3
7.2
9
*
Z70.8
ICD-10 Finland
Other sex counselling
30.3
7.2
9
*
K14.9
ICD-10 Finland
Disease of tongue, unspecified
20.2
7.1
10
5
R06AE07
ATC
cetirizine; oral
1.5
7.1
321
2474
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
7.1
307
2345
D07XC01
ATC
betamethasone, combinations; topical
2.0
7.1
88
465
UJF30
NOMESCO Finland
Ileoscopy through colon
2.1
6.9
77
389
-1
NOMESCO Finland
NA
1.6
6.9
223
1582
K13.21
ICD-10 Finland
Leukoplakia caused by tobacco
13.9
6.9
11
8
H04.10
ICD-10 Finland
Dry eye syndrome
2.0
6.9
87
463
K14.61
ICD-10 Finland
Glossodynia
6.8
6.8
16
24
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
6.8
181
1219
LFA00
NOMESCO Finland
Incision of vulva or perineum
16.9
6.8
10
6
A07EA06
ATC
budesonide; oral, local oral
3.2
6.7
33
106
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
6.6
178
1204
D19
ICPC
Teeth/gum symptom/complaint
1.6
6.6
190
1305
UJF32
NOMESCO Finland
Coloscopy
1.6
6.6
199
1386
E000006
ATC
NA
2.2
6.6
63
298
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
1.8
6.5
106
616
R05
ICD-10 Finland
Cough
1.7
6.5
148
954
EAA10
NOMESCO Finland
Excision of lesion of lip
5.4
6.5
18
34
L01
ICPC
Neck symptom/complaint
1.8
6.5
107
625
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.0
6.4
83
442
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.0
6.4
81
427
N06AA09
ATC
amitriptyline; systemic
1.9
6.3
88
483
SDA05
NOMESCO Finland
Very demanding and lengthy parodonthologic therapy
2.6
6.3
44
176
SPA51
NOMESCO Finland
Determination of bite and dental arch location, demanding
7.1
6.2
14
20
M79.1
ICD-10 Finland
Myalgia
1.9
6.2
95
542
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.5
6.2
409
3385
G01AA10
ATC
clindamycin; vaginal
1.7
6.2
132
836
J01MA02
ATC
ciprofloxacin; systemic
1.5
6.1
252
1888
WX290
NOMESCO Finland
Other blockade of nerve
1.5
6.1
287
2209
EBB11
NOMESCO Finland
Insertion of additional dental implant in one session
8.7
6.1
12
14
KMAK
NOMESCO Finland
NA
1.5
6.1
350
2815
GBB00
NOMESCO Finland
Tracheostomy
6.8
6.1
14
21
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.9
6.0
93
531
R52.9
ICD-10 Finland
Pain, unspecified
2.1
6.0
66
332
Mortality – FinRegistry
↥Association
Association between endpoint K11_ORAL_LICHEN_PLANUS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| K11_ORAL_LICHEN_PLANUS | 0.757 [0.57, 1.01] | 0.055 |
| Birth year | 0.998 [0.99, 1.01] | 0.563 |
During the follow-up period (1.1.1998 — 31.12.2019), 87 out of 1994 females with K11_ORAL_LICHEN_PLANUS died.
Males
No dataMortality risk
Mortality risk for people of age
years, who have K11_ORAL_LICHEN_PLANUS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.095% | No data |
| 5 | 0.439% | No data |
| 10 | 1.153% | No data |
| 15 | 2.282% | No data |
| 20 | 4.174% | No data |
Relationships between endpoints
↥Index endpoint: K11_ORAL_LICHEN_PLANUS – Oral lichen ruber planus
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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