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Oral lichen ruber planus wide, hypothyreosis or thyroxin

K11_ORAL_LICHEN_WIDE_HYPOT_THYRO

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • HYPOT_THYRO_INCL
66417

3. Check pre-conditions, main-only, mode, registry filters

None

0 out of 7 registries used, show all original rules.

0

4. Check minimum number of events

None

0

5. Include endpoints

1896

6. Filter based on genotype QC (FinnGen only)

1896

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
C
First used in FinnGen datafreeze
DF8

Similar endpoints

Case counts by codes

FinnGen case counts by registry codes:

No data for upset plot.

No data for upset table.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 1896 1633 263
Unadjusted period prevalence (%) 0.50 0.56 0.12
Median age at first event (years) 62.10 62.19 61.53

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1654
Matched controls
16539
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L43.9
ICD-10 Finland
Lichen planus, unspecified
86.8
323.0
628
116
L43.8
ICD-10 Finland
Other lichen planus
78.9
323.0
606
120
K13.74
ICD-10 Finland
Lichen rubs planus in the mouth
64.6
323.0
449
95
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
10.0
323.0
837
1539
H03AA01
ATC
levothyroxine sodium; systemic
460.6
323.0
1640
3350
L43
ICD-10 Finland
Lichen planus
56.0
252.1
299
65
D07AD01
ATC
clobetasol; topical
5.8
189.7
670
1745
D07AC01
ATC
betamethasone; topical
4.5
179.4
996
4136
EKA10
NOMESCO Finland
Biopsy of cheek
20.6
171.7
263
150
104
Kela drug reimbursment
Thyroid insufficiency
6.9
171.7
487
938
L43.0
ICD-10 Finland
Hypertrophic lichen planus
47.5
133.2
163
38
E03
ICD-10 Finland
Other hypothyroidism
6.5
121.9
351
658
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
8.6
87.4
200
260
SAA03
NOMESCO Finland
Extended examination of mouth
2.8
84.1
837
4418
E0000UV
ATC
NA
2.8
82.3
884
4868
D07AC13
ATC
mometasone; topical
2.8
76.8
694
3396
E03.89
ICD-10 Finland
Other specified hypothyroidism
6.6
74.1
202
339
K13.79
ICD-10 Finland
Change in the oral mucosa UNS
10.0
72.1
150
164
T86
ICPC
Hypothyroidism/myxoedema
5.6
64.2
201
400
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.0
63.6
451
1846
EJA10
NOMESCO Finland
Biopsy of tongue or floor of mouth
9.5
61.7
131
148
D07AB02
ATC
hydrocortisone butyrate; topical
2.5
60.7
646
3353
L43.3
ICD-10 Finland
Subacute (active) lichen planus
59.9
59.0
69
12
WZB00
NOMESCO Finland
Telephone receipt or other advice
2.5
57.7
607
3109
SAA01
NOMESCO Finland
Simple examination of mouth
2.4
55.5
1261
9386
SAA02
NOMESCO Finland
Basic examination of mouth
2.3
51.9
1140
8179
SBA00
NOMESCO Finland
Microbiological examinations
6.6
50.9
137
223
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.3
47.9
274
943
K13.78
ICD-10 Finland
Other change in the oral mucosa
8.1
47.2
110
145
A07AA02
ATC
nystatin; oral
3.7
46.2
224
679
ECA20
NOMESCO Finland
Biopsy of gingiva
10.5
44.2
88
88
K13.29
ICD-10 Finland
Indefinite leukoplakia
11.0
43.3
84
80
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
2.1
43.3
661
3915
SXA10
NOMESCO Finland
Epithel biopsy of mouth
12.0
42.0
78
68
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
2.0
39.6
843
5653
SFA10
NOMESCO Finland
Fillning on one surface of tooth
2.0
38.6
940
6613
A01AC01
ATC
triamcinolone; local oral
7.6
38.6
93
129
E03.80
ICD-10 Finland
Hypothyroidism caused by autoimmune thyroiditis
6.7
36.9
97
153
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.1
35.1
472
2592
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.9
34.0
974
7121
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.9
33.2
979
7203
WX110
NOMESCO Finland
Local anesthesy
1.9
32.8
1164
9128
E000001
ATC
NA
2.2
32.2
410
2184
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
3.9
30.5
134
370
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
4.1
29.5
121
314
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
4.4
29.5
111
266
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.7
29.4
223
908
R01AD11
ATC
triamcinolone; nasal
2.7
29.4
219
883
Z01.2
ICD-10 Finland
Dental examination
1.8
29.2
720
4898
SDA03
NOMESCO Finland
Demanding parodonthologic therapy
1.9
28.9
654
4316
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
28.7
560
3505
D82
ICPC
Teeth/gum disease
1.9
28.5
590
3767
A01AB09
ATC
miconazole; local oral
2.6
28.4
234
997
J02AC01
ATC
fluconazole; systemic
1.8
28.3
817
5832
R01AD09
ATC
mometasone; nasal
1.8
28.2
806
5735
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
27.9
828
5951
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
1.8
27.4
754
5283
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.8
27.3
710
4880
K02.1
ICD-10 Finland
Caries of dentine
1.8
27.2
912
6789
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
3.4
26.6
137
430
L43.1
ICD-10 Finland
Bullous lichen planus
37.4
26.2
33
9
SDA02
NOMESCO Finland
Parodonthologic therapy
1.8
25.8
592
3886
R06AE07
ATC
cetirizine; oral
1.7
25.6
798
5766
L43.2
ICD-10 Finland
Lichenoid drug reaction
50.9
25.3
30
6
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.7
25.1
829
6080
H02AB06
ATC
prednisolone; systemic
1.7
24.6
831
6125
N77.8*L43.9
ICD-10 Finland
Vulvovaginal ulceration and inflammation caused by lichen ruber planus
28.0
24.5
33
12
SDA01
NOMESCO Finland
Simple parodonthologic therapy
1.9
23.6
443
2700
D07AB08
ATC
desonide; topical
2.4
23.4
220
1002
WZA90
NOMESCO Finland
Other doctors statement
1.9
22.8
413
2480
SHB00
NOMESCO Finland
Prepation and fitting of bite rail to mouth
2.6
22.4
179
747
SDE02
NOMESCO Finland
Periodontal treatment by dental hygienist
1.8
22.4
449
2790
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.8
22.3
461
2893
A02BC05
ATC
esomeprazole; systemic
1.7
22.2
756
5518
K13.20
ICD-10 Finland
Idiopathic leukoplakia
14.5
22.2
37
26
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.7
21.8
686
4890
E000006
ATC
NA
2.5
21.5
178
756
SDA04
NOMESCO Finland
Very demanding parodonthologic therapy
1.8
21.5
412
2517
R03AC02
ATC
salbutamol; inhalant
1.6
21.3
897
6920
R06AX27
ATC
desloratadine; oral
1.8
21.3
473
3029
L28.0
ICD-10 Finland
Lichen simplex chronicus
10.0
21.1
42
43
D05BB02
ATC
acitretin; oral
4.6
20.8
74
168
ULA02
NOMESCO Finland
Kolposcopy
2.3
20.5
201
932
SAA04
NOMESCO Finland
Special inverstigation of mouth
2.9
20.5
131
477
A02BC02
ATC
pantoprazole; systemic
1.7
20.4
1123
9260
B37.03
ICD-10 Finland
Chronic atrophic candida infection in the mouth
22.7
20.4
29
13
E03.0
ICD-10 Finland
Congenital hypothyroidism with diffuse goitre
9.5
19.6
40
43
SCA01
NOMESCO Finland
Simple analysis and advice of nutrition with regard to dentistry
1.8
19.6
440
2815
A06AC01
ATC
ispaghula (psylla seeds); oral
1.7
19.5
505
3376
XQ802
NOMESCO Finland
Epicutan test
3.2
19.2
103
334
-1
NOMESCO Finland
NA
1.7
19.1
521
3530
LEB00
NOMESCO Finland
Biopsy of vagina
4.6
19.1
67
151
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
19.0
609
4313
A02BC03
ATC
lansoprazole; oral
1.7
18.9
549
3782
R01AD08
ATC
fluticasone; nasal
1.7
18.9
501
3362
K03.64
ICD-10 Finland
Dental calculus supragingival
1.7
18.9
458
2996
D07BC01
ATC
betamethasone and antiseptics; topical
2.1
18.8
228
1162
N06AA09
ATC
amitriptyline; systemic
2.1
18.8
227
1155
G03CA03
ATC
estradiol; nasal, systemic, rectal, transdermal, vaginal
1.6
18.7
1079
8889
D20
ICPC
Mouth/tongue/lip symptom/complaint
2.9
18.4
115
412
SHA01
NOMESCO Finland
Correction of physiology of bite - simple therapy visit
2.2
18.0
194
940
SPAT1301
SPAT
No procedures
1.6
17.9
551
3845
K13.28
ICD-10 Finland
Other leukoplakia or disorder of epithelium of the palate or tongue
16.7
17.9
28
17
J01AA02
ATC
doxycycline; systemic
1.7
17.8
1330
11653
E05.0
ICD-10 Finland
Thyrotoxicosis with diffuse goitre
3.4
17.6
87
266
B37.08
ICD-10 Finland
Other candidal stomatitis
8.1
17.5
39
49
KMAK
NOMESCO Finland
NA
1.6
17.4
827
6435
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
6.3
17.3
46
75
D02AE01
ATC
carbamide; topical
2.5
17.2
143
606
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
2.1
17.1
214
1104
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
17.0
636
4656
N02BE01
ATC
paracetamol; systemic, rectal
1.8
16.7
1449
13107
VALMI
NOMESCO Finland
NA
1.7
16.7
392
2524
M25.5
ICD-10 Finland
Pain in joint
1.6
16.5
503
3484
K12.10
ICD-10 Finland
Stomatitis NOS
11.7
16.5
30
26
H03BB01
ATC
carbimazole; oral
2.8
16.5
107
395
UJF32
NOMESCO Finland
Coloscopy
1.7
16.5
480
3283
SPAT1260
SPAT
Consultation of another employee
1.8
16.4
326
1994
J01DA01
ATC
[U] cefalexin; systemic
1.5
16.1
1029
8518
N06AX11
ATC
mirtazapine; oral
1.6
16.1
554
3958
69700
ICD-8 Finland
Lichen, Planus
48.0
16.0
19
*
J01DB01
ATC
cefalexin; oral
1.7
15.9
1331
11772
M79.6
ICD-10 Finland
Pain in limb
1.6
15.8
626
4625
L08
ICPC
Shoulder symptom/complaint
1.7
15.7
351
2220
N06AX16
ATC
venlafaxine; oral
1.9
15.7
243
1362
A01AB04
ATC
amphotericin B; local oral
2.6
15.5
119
486
S29
ICPC
Skin symptom/complaint other
1.8
15.4
310
1898
E89.01
ICD-10 Finland
Postsurgical hypothyroidism
4.2
15.4
58
141
M01AH05
ATC
etoricoxib; oral
1.5
15.2
982
8093
SDE03
NOMESCO Finland
Periodontal treatment by dental hygienist, extensive
1.7
15.0
409
2739
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
14.9
373
2435
S18
ICPC
Laceration/cut
1.5
14.8
704
5406
S21
ICPC
Skin texture symptom/complaint
1.9
14.6
229
1289
N06AB04
ATC
citalopram; systemic
1.7
14.5
387
2571
TQW80
NOMESCO Finland
Local dermatologic skincare
3.8
14.5
62
169
R06AE09
ATC
levocetirizine; oral
1.8
14.5
251
1462
SHA02
NOMESCO Finland
Correction of physiology of bite - basic therapy visit
2.4
14.0
118
507
M79.1
ICD-10 Finland
Myalgia
1.9
14.0
231
1322
K04.5
ICD-10 Finland
Chronic apical periodontitis
1.6
13.9
393
2646
M03BX02
ATC
tizanidine; oral
1.5
13.8
1021
8576
SPAT1263
SPAT
Sampling
1.5
13.8
691
5340
M01AE02
ATC
naproxen; oral, rectal
1.5
13.8
918
7543
J01CA04
ATC
amoxicillin; systemic
1.6
13.7
1289
11426
D09AB01
ATC
zinc bandage without supplements; topical
4.1
13.4
52
131
C07AA05
ATC
propranolol; systemic
1.7
13.4
335
2180
R05
ICPC
Cough
1.6
13.3
386
2613
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.6
13.2
368
2468
N02AX02
ATC
tramadol; systemic, rectal
1.5
13.2
698
5446
WX290
NOMESCO Finland
Other blockade of nerve
1.5
13.1
616
4678
N03AX16
ATC
pregabalin; oral
1.6
13.1
423
2946
E000002
ATC
NA
1.9
12.9
190
1039
C05AA08
ATC
fluocortolone; rectal, topical
1.8
12.8
255
1548
SPAT1153
SPAT
Removal of sutures
1.5
12.8
559
4177
SFA00
NOMESCO Finland
Small filling
1.8
12.6
225
1322
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
3.3
12.5
63
197
M79.0
ICD-10 Finland
Rheumatism, unspecified
2.6
12.5
92
366
A98
ICPC
Health maint/preventive medicine
2.4
12.4
1597
15213
SXC05
NOMESCO Finland
Other oral or dental procedure
2.5
12.4
99
413
L17
ICPC
Foot/toe symptom/complaint
1.6
12.4
433
3065
K30
ICD-10 Finland
Functional dyspepsia
1.9
12.4
195
1096
H04.10
ICD-10 Finland
Dry eye syndrome
1.9
12.3
207
1186
SBB10
NOMESCO Finland
Teeth copy
2.5
12.3
98
408
K05.10
ICD-10 Finland
Gingivitis (chronic) NOS
1.9
12.3
201
1143
K07.60
ICD-10 Finland
Snapping jaw
2.6
12.2
91
365
SAD01
NOMESCO Finland
Assessment of need for oral health care, standard
1.9
12.2
192
1077
E89.00
ICD-10 Finland
Postirradiation hypothyroidism
4.6
12.2
41
90
SCA02
NOMESCO Finland
Analysis and advice of nutrition with regard to dentistry
2.0
12.1
151
777
M75.1
ICD-10 Finland
Rotator cuff syndrome
1.6
12.1
402
2811
BAA60
NOMESCO Finland
Total thyroidectomy
3.1
12.1
66
220
B37.01
ICD-10 Finland
Acute athrophy candidal stomatitis
18.2
12.0
18
10
K29.4
ICD-10 Finland
Chronic atrophic gastritis
3.6
12.0
53
150
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
12.0
248
1524
XQ848
NOMESCO Finland
Dermatological photography
3.4
11.9
56
167
SXA20
NOMESCO Finland
Local application of medicine to mouth
2.5
11.9
95
396
J01FA10
ATC
azithromycin; systemic
1.4
11.9
932
7807
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.5
11.8
478
3494
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.5
11.7
703
5580
SHA03
NOMESCO Finland
Correction of physiology of bite - demanding therapy visit
3.1
11.7
63
208
R07.4
ICD-10 Finland
Chest pain, unspecified
1.5
11.6
453
3279
B03BA03
ATC
hydroxocobalamin; parenteral
2.4
11.6
102
449
D19
ICPC
Teeth/gum symptom/complaint
1.5
11.5
402
2838
E05.9
ICD-10 Finland
Thyrotoxicosis, unspecified
3.0
11.5
67
233
EJ2S1
NOMESCO Finland
Photography of oral mucosa
13.7
11.5
19
14
N06AX21
ATC
duloxetine; oral
1.8
11.4
199
1158
R01BA52
ATC
pseudoephedrine, combinations; oral
1.5
11.3
554
4210
K02.0
ICD-10 Finland
Caries limited to enamel
1.8
11.2
188
1079
SFA40
NOMESCO Finland
Replacement of krone of tooth
1.6
11.2
345
2363
L15
ICPC
Knee symptom/complaint
1.6
11.1
379
2657
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.8
11.1
205
1212
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.1
11.1
134
679
N06AB10
ATC
escitalopram; oral
1.6
11.1
298
1969
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
11.0
283
1849
D06BX01
ATC
metronidazole; topical
1.8
10.9
194
1135
M54.5
ICD-10 Finland
Low back pain
1.5
10.9
525
3971
M01AX17
ATC
nimesulide; oral
1.5
10.9
433
3146
WYA10
NOMESCO Finland
First aid or other corresponding healthcare contact
2.0
10.8
135
695
B37.09
ICD-10 Finland
Unspecified candidal stomatitis
5.1
10.8
33
66
A02BC01
ATC
omeprazole; systemic
1.5
10.8
462
3407
SPAT1312
SPAT
General health counselling
1.5
10.8
510
3841
R06.0
ICD-10 Finland
Dyspnoea
1.5
10.8
416
3000
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
2.5
10.7
85
354
F45.8
ICD-10 Finland
Other somatoform disorders
2.2
10.7
110
522
P01AB01
ATC
metronidazole; oral, rectal
1.4
10.7
678
5407
XQ800
NOMESCO Finland
Prick test
2.1
10.6
125
629
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.8
10.6
44
119
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.9
10.6
62
217
G44.2
ICD-10 Finland
Tension-type headache
1.7
10.6
233
1455
T89
ICPC
Diabetes insulin dependent
3.0
10.5
58
195
M03BC01
ATC
orphenadrine (citrate); systemic
1.5
10.5
369
2599
D07CA01
ATC
hydrocortisone and antibiotics; topical
1.7
10.5
221
1362
EBA00
NOMESCO Finland
Extraction of tooth
1.5
10.4
468
3480
R01AD12
ATC
fluticasone furoate; nasal
1.5
10.4
448
3303
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.4
10.4
760
6218
R13
ICD-10 Finland
Dysphagia
2.1
10.3
116
574
N05CF02
ATC
zolpidem; oral
1.6
10.3
306
2074
D07CC01
ATC
betamethasone and antibiotics; topical
1.7
10.2
206
1253
EMAK
NOMESCO Finland
NA
2.5
10.2
76
308
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
10.2
499
3775
D07XC01
ATC
betamethasone, combinations; topical
1.8
10.2
194
1161
G01AA10
ATC
clindamycin; vaginal
1.6
10.1
296
1995
K05.1
ICD-10 Finland
Chronic gingivitis
2.1
10.1
121
613
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.7
10.0
203
1237
R01AD01
ATC
beclometasone; nasal
1.6
10.0
266
1747
SXB00
NOMESCO Finland
Removeal of sutres from oral mucosa
2.2
10.0
105
503
J31.0
ICD-10 Finland
Chronic rhinitis
2.0
10.0
133
704
K12.18
ICD-10 Finland
Other forms of stomatitis
5.8
10.0
27
47
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
2.0
10.0
128
666
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
10.0
202
1232
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
1.7
9.9
200
1216
C02.11
ICD-10 Finland
Malignant neoplasm of border of tongue
7.7
9.9
22
29
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
1.9
9.8
151
841
A06AD11
ATC
lactulose; oral
1.7
9.8
223
1402
SPAT1310
SPAT
Counselling related to known health issue
1.4
9.8
525
4037
B81
ICPC
Anaemia vit B12/folate deficiency
2.5
9.8
74
302
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
2.2
9.8
98
460
M01AX05
ATC
glucosamine; oral
1.5
9.7
408
2986
BAA40
NOMESCO Finland
Unilateral lobectomy of thyroid gland
2.8
9.7
62
230
M01AC06
ATC
meloxicam; systemic, rectal
1.4
9.7
649
5202
R05
ICD-10 Finland
Cough
1.5
9.7
324
2254
SXC02
NOMESCO Finland
Other oral or dental procedure, restricted
2.8
9.6
60
217
D07AA02
ATC
hydrocortisone; topical
1.7
9.5
203
1254
N05BB01
ATC
hydroxyzine; systemic
2.1
9.5
110
547
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.7
9.5
228
1456
N06AB06
ATC
sertraline; oral
1.8
9.5
171
1002
R49.08
ICD-10 Finland
Other specified dysphonia
3.2
9.5
48
153
N06AB03
ATC
fluoxetine; oral
1.7
9.5
218
1376
R52.9
ICD-10 Finland
Pain, unspecified
1.9
9.5
148
830
S01GX01
ATC
cromoglicic acid; ophthalmic
1.5
9.5
326
2280
J05AB01
ATC
aciclovir; systemic
1.5
9.5
354
2524
R23.8
ICD-10 Finland
Other and unspecified skin changes
1.6
9.4
257
1701
K12.00
ICD-10 Finland
Recurrent oral aphthae
4.4
9.4
33
77
M02AA07
ATC
piroxicam; topical
1.4
9.3
634
5082
L03
ICPC
Low back symptom/complaint
1.5
9.3
396
2904
24409
ICD-8 Finland
Myxoedema, (hypothyreosis) NUD
9.6
9.3
18
19
EJB10
NOMESCO Finland
Excision of lesion of apex or body of tongue
6.5
9.3
23
36
N47
ICD-10 Finland
Redundant prepuce, phimosis and paraphimosis
6.1
9.2
24
40
UDQ12
NOMESCO Finland
Flexible laryngoscopy
2.2
9.2
96
457
PJD71
NOMESCO Finland
Extended sparing excision of cervical lymph nodes
6.7
9.1
22
33
R06AX22
ATC
ebastine; oral
1.6
9.1
292
2008
A10AE04
ATC
insulin glargine; parenteral
1.9
9.1
130
706
L30.0
ICD-10 Finland
Nummular dermatitis
2.7
9.1
61
231
N03AX09
ATC
lamotrigine; oral
2.5
9.0
69
284
J02AC02
ATC
itraconazole; systemic
1.5
9.0
309
2160
N76.3
ICD-10 Finland
Subacute and chronic vulvitis
4.9
9.0
28
58
SPAT1249
SPAT
Treatment-related counselling outside office
1.4
9.0
627
5044
M01AE01
ATC
ibuprofen; systemic, rectal
1.5
9.0
1422
13220
R53
ICD-10 Finland
Malaise and fatigue
1.5
8.9
313
2200
107
Kela drug reimbursment
Pernicious anaemia
3.3
8.9
43
133
E000007
ATC
NA
2.1
8.9
96
465
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
2.9
8.8
51
178
TEA00
NOMESCO Finland
Biopsy of lip
4.4
8.7
30
69
SCA03
NOMESCO Finland
Preventive oral health care, extensive
2.3
8.7
76
337
J01MA02
ATC
ciprofloxacin; systemic
1.4
8.6
577
4602
M70.6
ICD-10 Finland
Trochanteric bursitis
1.6
8.6
252
1697
E03.2
ICD-10 Finland
Hypothyroidism due to medicaments and other exogenous substances
7.0
8.5
20
29
M01AB05
ATC
diclofenac; systemic, rectal
1.4
8.5
1049
9244
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
1.7
8.5
175
1070
R96
ICPC
Asthma
1.8
8.5
155
914
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.5
8.5
275
1896
TLE00
NOMESCO Finland
Dilatation of vagina
90.5
8.4
9
*
K05.31
ICD-10 Finland
Periodontitis pronounced
1.7
8.4
158
942
G47.3
ICD-10 Finland
Sleep apnoea
1.5
8.4
289
2020
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.6
8.4
207
1333
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
2.8
8.3
50
180
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
1.7
8.3
193
1223
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.5
8.3
327
2354
K03.82
ICD-10 Finland
Split tooth for reasons other than trauma
1.8
8.2
130
729
M03BC51
ATC
orphenadrine, combinations; systemic
1.4
8.2
456
3507
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
1.9
8.2
128
716
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
6.5
8.2
20
31
KGH10
NOMESCO Finland
Operation for phimosis
6.5
8.2
20
31
H02AB04
ATC
methylprednisolone; systemic
1.6
8.1
246
1670
C06.0
ICD-10 Finland
Malignant neoplasm: Cheek mucosa
17.3
8.1
12
7
K13.2
ICD-10 Finland
Leukoplakia and other disturbances of oral epithelium, including tongue
11.8
8.1
14
12
R74
ICPC
Upper respiratory infection acute
1.4
8.0
382
2855
H3600, E103
ICD-10 Finland
NA
6.3
8.0
20
32
UJF30
NOMESCO Finland
Ileoscopy through colon
1.7
8.0
153
917
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.5
8.0
308
2205
J01FF01
ATC
clindamycin; systemic
1.4
7.9
409
3100
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.9
7.9
112
605
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
7.9
654
5381
TEW99
NOMESCO Finland
Other minor procedure in surgery of teeth, jaws, mouth and pharynx
2.2
7.9
78
367
K08.80
ICD-10 Finland
Toothache NOS
1.9
7.8
119
662
D01
ICPC
Abdominal pain/cramps general
1.7
7.8
164
1010
M01AE03
ATC
ketoprofen; systemic, rectal
1.4
7.8
596
4840
J01EA01
ATC
trimethoprim; systemic
1.4
7.7
454
3520
A10AA02
ATC
NA
2.8
7.7
46
165
M17.1
ICD-10 Finland
Other primary gonarthrosis
1.4
7.7
370
2766
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.7
7.7
163
1005
EKB00
NOMESCO Finland
Excision of lesion of cheek
7.5
7.7
17
23
SGA03
NOMESCO Finland
Demanding opening and dilatation of root canal of tooth
1.8
7.6
132
765
SAB01
NOMESCO Finland
Restricted oral and dental health check by dental hygienist or dental assistant
1.9
7.6
114
631
L16
ICPC
Ankle symptom/complaint
1.7
7.6
159
978
6970A
ICD-9 Finland
Lichen planus[LICHEN RUBER PLANUS]
25.1
7.6
10
*
R21
ICPC
Throat symptom/complaint
1.5
7.6
262
1828
J01FA09
ATC
clarithromycin; systemic
1.4
7.6
493
3890
R51.80
ICD-10 Finland
Headache
1.6
7.6
217
1453
N05BA04
ATC
oxazepam; oral
1.4
7.6
398
3026
N05BA01
ATC
diazepam; systemic, rectal
1.6
7.5
215
1437
R42
ICD-10 Finland
Dizziness and giddiness
1.4
7.5
355
2644
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.0
7.5
97
508
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
7.5
381
2875
SGA02
NOMESCO Finland
Opening and dilatation of root canal of tooth
1.6
7.5
174
1104
K04.08
ICD-10 Finland
Other specified pulpit
2.1
7.5
82
403
EBA05
NOMESCO Finland
Complicated extraction of tooth
1.5
7.4
262
1836
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
1.6
7.4
198
1301
A04
ICPC
Weakness/tiredness general
1.6
7.4
193
1258
J01MA12
ATC
levofloxacin; systemic
1.5
7.4
264
1857
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.9
7.4
100
534
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
7.3
708
5944
UKC02
NOMESCO Finland
Cystoscopy
1.6
7.3
207
1377
N05CF01
ATC
zopiclone; oral
1.4
7.3
525
4208
R03BA01
ATC
beclometasone; inhalant
1.5
7.2
226
1542
A10AA01
ATC
NA
3.0
7.2
38
127
K13.1
ICD-10 Finland
Cheek and lip biting
7.3
7.2
16
22
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
3.1
7.2
36
116
2500B
ICD-9 Finland
Diabetes mellitus without mention of complication[DIABETES MELLITUS SINE COMPLICATIONE ,TYYPPI I]
3.6
7.2
30
84
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.5
7.2
295
2134
N77.8
ICD-10 Finland
Vulvovaginal ulceration and inflammation in other diseases classified elsewhere
30.1
7.1
9
*
N01
ICPC
Headache
1.7
7.1
135
808
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
1.4
7.1
319
2351
M53.0
ICD-10 Finland
Cervicocranial syndrome
1.7
7.1
136
816
L28.1
ICD-10 Finland
Prurigo nodularis
5.6
7.1
19
34
A01AB10
ATC
natamycin; local oral
2.4
7.0
57
245
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
7.0
111
627
SGC00
NOMESCO Finland
Local medication of root channels of tooth
1.7
7.0
142
868
R03BA08
ATC
ciclesonide; inhalant
1.7
7.0
142
868
K11.70
ICD-10 Finland
Hypoptyalism
4.9
7.0
21
43
K59.0
ICD-10 Finland
Constipation
1.9
6.9
93
496
L02
ICPC
Back symptom/complaint
1.7
6.9
146
904
R02
ICPC
Shortness of breath/dyspnoea
1.6
6.9
186
1226
EB1CA
NOMESCO Finland
Tooth X-ray additional picture
1.7
6.9
139
847
N06AA12
ATC
doxepin; systemic
1.9
6.8
94
504
C73.91
ICD-10 Finland
Papillary carcinoma of the thyroid gland (thyroid gland)
3.2
6.8
33
104
L13
ICPC
Hip symptom/complaint
1.5
6.8
280
2024
J45.9
ICD-10 Finland
Asthma, unspecified
1.5
6.8
280
2025
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
1.9
6.8
96
522
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.9
6.8
98
538
K60.1
ICD-10 Finland
Chronic anal fissure
2.8
6.8
41
150
EHA10
NOMESCO Finland
Biopsy of palate
5.7
6.8
18
32
N03AX12
ATC
gabapentin; oral
1.5
6.8
250
1772
R03DC03
ATC
montelukast; oral
1.5
6.7
251
1779
H13
ICPC
Plugged feeling ear
1.5
6.7
263
1882
A02BC04
ATC
rabeprazole; oral
1.7
6.7
136
829
N76.1
ICD-10 Finland
Subacute and chronic vaginitis
3.2
6.7
32
100
Z76.0
ICD-10 Finland
Issue of repeat prescription
1.5
6.7
203
1378
J38.0
ICD-10 Finland
Paralysis of vocal cords and larynx
3.2
6.7
33
106
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
1.4
6.7
295
2164
S99
ICPC
Skin disease other
2.9
6.6
38
132
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
1.9
6.6
98
539
H01
ICPC
Ear pain/earache
1.7
6.6
149
936
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.3
6.6
624
5201
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
2.9
6.6
38
134
K13.22
ICD-10 Finland
Erythroplakia of oral epithelium, including tongue
8.7
6.6
13
15
L01
ICPC
Neck symptom/complaint
1.5
6.5
217
1500
M54.4
ICD-10 Finland
Lumbago with sciatica
1.5
6.5
247
1756
R03BA02
ATC
budesonide; inhalant
1.4
6.5
275
2001
H92.0
ICD-10 Finland
Otalgia
2.0
6.5
77
391
R03AK06
ATC
salmeterol and fluticasone; inhalant
1.5
6.5
205
1399
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.9
6.5
91
494
G43.9
ICD-10 Finland
Migraine, unspecified
2.0
6.4
77
394
L28
ICPC
Limited function/disability (L)
1.5
6.4
250
1787
A02BA02
ATC
ranitidine; systemic
1.4
6.4
319
2390
M19.0
ICD-10 Finland
Primary arthrosis of other joints
1.6
6.4
160
1032
A07EA02
ATC
hydrocortisone; rectal
2.9
6.4
37
130
K03.80
ICD-10 Finland
Irradiated enamel
2.0
6.4
76
385
K05.30
ICD-10 Finland
Periodontitis complex
1.5
6.4
191
1288
B37.0
ICD-10 Finland
Candidal stomatitis
3.5
6.4
27
77
PAD
NOMESCO Finland
NA
14.4
6.4
10
7
E000004
ATC
NA
2.7
6.4
41
154
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
1.9
6.3
90
490
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
1.6
6.3
156
1004
SPAT1043
SPAT
Audiometry
1.6
6.3
165
1078
S06
ICPC
Rash localized
1.9
6.3
92
507
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
2.1
6.2
64
308
S08
ICPC
Skin colour change
1.9
6.2
85
456
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.3
6.2
460
3689
D01BA02
ATC
terbinafine; oral; topical
1.4
6.2
351
2692
S02.51
ICD-10 Finland
Fracture of tooth, open
1.6
6.2
155
1004
K59.09
ICD-10 Finland
Constipation, unspecified
1.8
6.2
100
569
J01AA07
ATC
tetracycline; systemic
1.5
6.2
210
1462
H02AB09
ATC
hydrocortisone; systemic
2.7
6.2
40
152
D07AC14
ATC
methylprednisolone aceponate; topical
1.9
6.1
79
417
O24.0
ICD-10 Finland
Diabetes mellitus in pregnancy: Pre-existing diabetes mellitus, insulin-dependent
4.7
6.1
19
41
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
4.7
6.1
19
41
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
1.7
6.1
130
806
A10AE06
ATC
insulin degludec; parenteral
2.6
6.1
40
154
N06AX12
ATC
bupropion; oral
2.0
6.1
72
368
F34.1
ICD-10 Finland
Dysthymia
2.3
6.1
53
238
C07AB07
ATC
bisoprolol; oral
1.3
6.0
729
6261
EBA10
NOMESCO Finland
Surgical removal of tooth
1.7
6.0
123
753
K03.00
ICD-10 Finland
Approximal wear
2.0
6.0
76
398
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
2.7
6.0
37
138
A03FA02
ATC
cisapride; oral, rectal
1.6
6.0
136
858
N17
ICPC
Vertigo/dizziness
1.5
6.0
184
1250

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: K11_ORAL_LICHEN_WIDE_HYPOT_THYRO – Oral lichen ruber planus wide, hypothyreosis or thyroxin

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).