obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
261 |
4. Check minimum number of eventsNone |
261 |
5. Include endpointsNone |
261 |
6. Filter based on genotype QC (FinnGen only) |
261 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Other and unspecified disorders of pigmentation
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2175 | 1280 | 875 |
| Only index persons | 1843 | 1136 | 707 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.04 | 0.02 |
| Only index persons | 0.04 | 0.04 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 36.01 | 39.30 | 30.99 |
| Only index persons | 39.15 | 41.63 | 35.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 261 | 175 | 86 |
| Unadjusted period prevalence (%) | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | 48.01 | 46.65 | 50.77 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 231
- Matched controls
- 2311
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.9
ICD-10 Finland
Disorder of pigmentation, unspecified
2682.2
145.0
125
*
L81.8
ICD-10 Finland
Other specified disorders of pigmentation
+∞
113.1
99
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
14.8
36.7
64
58
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
57.5
9.7
11
*
R23.8
ICD-10 Finland
Other and unspecified skin changes
3.5
9.6
47
157
L30.9
ICD-10 Finland
Dermatitis, unspecified
3.1
9.0
54
209
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
93.3
8.5
9
*
L81.0
ICD-10 Finland
Postinflammatory hyperpigmentation
+∞
7.3
7
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
14.4
7.0
11
8
J01DB01
ATC
cefalexin; oral
2.5
6.8
195
1581
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
6.4
94
568
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
4.1
6.4
24
64
XQ848
NOMESCO Finland
Dermatological photography
9.7
6.4
12
13
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
4.1
6.3
23
60
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
27.5
6.3
8
*
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
53
202
3.04
10.66
6.0
5.5
1.1
1.1
mmol/l
0.24
48
186
125
776
2.18
8.61
5.1
4.3
35.3
36.3
g/l
1.07
114
735
111
677
2.12
7.81
4.2
3.0
—
—
—
0
0
55
251
2.51
7.71
2.3
2.2
2.3
2.4
g/l
0.71
49
233
53
238
2.54
7.68
2.4
2.3
21.6
23.9
%
0.55
45
208
81
439
2.23
7.68
2.5
2.1
3.0
3.1
mg/l
0.03
70
383
147
1023
2.01
6.96
6.9
6.0
9.9
10.2
umol/l
0.30
137
974
199
1557
2.19
6.68
10.0
6.9
75.4
75.6
u/l
0.03
182
1457
143
1008
1.93
6.29
4.9
3.4
0.0
0.0
estimate
0.00
31
181
145
1028
1.93
6.26
4.9
3.4
0.0
0.0
estimate
0.00
34
173
143
1016
1.91
6.06
5.9
4.7
0.0
0.0
estimate
0.00
33
178
84
526
1.88
5.07
4.0
2.9
0.2
0.4
e6/l
0.97
65
388
83
522
1.87
4.93
6.3
3.7
0.0
0.0
estimate
0.50
31
177
120
847
1.77
4.85
2.8
2.2
76.4
76.3
nmol/l
0.02
106
762
20
70
3.01
4.61
2.0
2.2
—
—
—
0
0
72
442
1.87
4.57
2.0
1.7
0.7
1.2
mg/l
1.83
49
335
240
2128
2.66
4.53
20.2
11.6
20.2
21.3
mg/l
0.21
197
1621
169
1335
1.76
4.46
6.0
4.1
138.6
220.1
e6/l
—
5
27
115
820
1.72
4.37
5.8
5.7
1.2
1.2
mmol/l
0.48
100
758
124
906
1.70
4.28
6.7
6.5
1.2
1.2
mmol/l
0.02
100
781
188
1543
1.79
4.22
6.2
3.8
12.5
10.3
mm/h
1.43
173
1447
127
937
1.69
4.21
3.4
2.6
133.9
93.8
ug/l
1.08
115
878
29
130
2.39
4.17
2.5
2.8
67.4
66.6
g/l
0.21
29
120
196
1636
1.80
4.06
5.2
3.8
15.0
14.6
pmol/l
1.18
174
1512
23
94
2.59
4.01
3.4
2.6
0.7
1.5
mmol/l
0.47
17
67
69
435
1.80
3.97
1.5
1.4
22.0
21.8
nmol/l
0.04
58
376
92
631
1.71
3.94
3.4
3.3
2.3
2.3
mmol/l
0.22
80
562
238
2129
2.39
3.92
19.9
12.9
139.4
139.8
mmol/l
1.68
230
2069
155
1220
1.67
3.91
13.6
9.4
4.2
4.0
e9/l
0.66
141
1080
237
2131
2.27
3.60
20.4
13.0
4.0
3.9
mmol/l
1.33
230
2068
79
534
1.69
3.51
2.1
2.0
140.3
202.4
u/l
0.80
74
511
50
296
1.85
3.50
1.9
1.7
—
—
—
0
0
77
520
1.68
3.43
1.4
1.3
1.9
1.5
u/ml
0.17
26
150
13
42
3.21
3.42
1.7
1.5
—
—
—
0
0
106
780
1.61
3.35
5.3
3.4
—
—
—
0
0
58
365
1.76
3.32
2.0
1.7
425.5
467.2
pmol/l
0.62
47
323
101
738
1.60
3.27
2.1
1.8
99.4
98.6
pmol/l
0.07
53
358
96
702
1.58
3.06
4.0
3.3
26.6
33.2
ng/l
0.42
62
430
143
1147
1.55
3.01
4.9
4.4
6.5
6.5
mmol/l
0.07
137
1050
25
122
2.16
2.98
1.4
1.5
—
—
—
0
0
94
688
1.57
2.97
4.6
3.1
35.6
29.4
u/l
1.01
88
661
11
36
3.15
2.84
1.7
1.6
—
—
—
0
0
25
126
2.09
2.76
3.8
3.8
1.2
1.2
mmol/l
0.02
20
115
34
194
1.87
2.67
3.6
4.5
230.9
246.8
u/l
0.27
29
183
29
157
1.95
2.65
3.5
3.0
—
—
—
0
0
86
632
1.54
2.62
2.6
2.3
68.5
56.3
u/l
0.63
80
587
218
1958
1.70
2.57
6.4
4.5
1.7
1.9
mu/l
1.45
201
1820
5
7
7.25
2.56
1.0
1.9
—
—
—
0
0
5
7
7.25
2.56
1.0
1.9
—
—
—
0
0
71
503
1.57
2.53
5.1
3.7
13.7
11.1
mg/mmol
0.15
41
312
15
63
2.47
2.51
1.2
1.3
15.6
9.5
u/ml
—
5
12
7
16
4.46
2.49
1.3
1.0
—
—
—
0
0
16
70
2.37
2.46
3.1
2.1
—
—
—
0
0
5
8
6.34
2.38
1.0
1.8
—
—
—
0
0
13
53
2.53
2.31
1.2
1.4
—
—
—
0
0
18
86
2.17
2.29
1.3
2.2
45.4
40.4
u/l
0.57
18
75
6
13
4.70
2.28
1.0
1.1
—
—
—
0
0
34
205
1.76
2.25
1.9
1.6
—
—
—
0
0
32
190
1.78
2.23
2.1
1.8
—
—
—
0
0
11
43
2.63
2.12
1.8
1.4
—
—
—
0
0
9
31
2.97
2.09
2.0
1.5
—
—
—
0
0
65
470
1.51
2.09
1.7
1.5
—
—
—
0
0
5
10
5.07
2.08
1.0
1.7
—
—
—
0
0
5
10
5.07
2.08
1.0
1.7
—
—
—
0
0
5
10
5.07
2.08
1.0
1.7
—
—
—
0
0
5
10
5.07
2.08
1.0
1.7
—
—
—
0
0
37
234
1.68
2.07
2.1
2.3
4.6
6.3
umol/l
1.41
30
202
216
1965
1.59
2.07
19.0
10.7
84.1
85.9
ml/min/173m2
0.47
184
1571
6
15
4.07
2.05
1.3
1.2
—
—
—
0
0
34
211
1.70
2.04
1.9
1.6
—
—
—
0
0
24
134
1.87
2.03
2.3
2.1
12.2
13.5
nmol/l
0.25
16
125
7
21
3.40
1.98
1.1
1.3
—
—
—
0
0
19
99
1.99
1.96
1.3
1.3
—
—
—
0
0
26
151
1.80
1.96
1.9
1.7
—
—
—
0
0
19
100
1.97
1.91
1.7
1.5
—
—
—
0
0
44
298
1.57
1.89
2.0
1.6
972.7
1231.8
nmol/l
1.71
37
231
13
59
2.27
1.87
1.7
1.2
—
—
—
0
0
10
40
2.56
1.86
1.5
1.3
—
—
—
0
0
175
1545
1.41
1.80
3.1
3.3
—
—
—
0
0
241
2274
1.82
1.75
14.6
9.1
25.8
25.9
u/l
0.03
234
2207
67
505
1.44
1.74
4.4
2.7
335.7
9092.2
umol/l
3.16
60
449
46
325
1.50
1.64
3.3
2.6
1.1
0.9
e6/l
0.13
28
182
14
70
2.06
1.62
2.0
1.9
—
—
—
0
0
10
43
2.38
1.62
1.9
1.5
—
—
—
0
0
7
26
2.74
1.59
3.6
3.5
—
—
—
0
0
10
45
2.27
1.48
1.4
1.2
—
—
—
0
0
36
247
1.53
1.48
2.5
1.8
29.4
28.9
s
0.35
36
241
5
16
3.16
1.44
1.0
1.9
—
—
—
0
0
5
16
3.16
1.44
1.0
1.9
—
—
—
0
0
5
16
3.16
1.44
1.0
1.9
—
—
—
0
0
6
22
2.77
1.44
1.0
1.2
—
—
—
0
0
6
22
2.77
1.44
1.0
1.2
—
—
—
0
0
10
46
2.22
1.41
3.8
2.2
3.3
3.8
g/l
—
10
46
6
23
2.65
1.37
1.0
1.2
—
—
—
0
0
6
23
2.65
1.37
1.0
1.2
—
—
—
0
0
6
23
2.65
1.37
1.0
1.2
—
—
—
0
0
5
17
2.98
1.36
1.0
1.9
—
—
—
0
0
5
17
2.98
1.36
9.6
8.1
0.6
0.6
mmol/l
—
5
17
5
17
2.98
1.36
1.0
1.2
—
—
—
0
0
0
37
0.00
1.35
0.0
1.3
—
7.2
—
0
22
13
69
1.93
1.31
1.6
1.6
—
—
—
0
0
5
18
2.81
1.29
1.2
1.6
—
—
—
0
0
5
18
2.81
1.29
1.0
1.9
—
—
—
0
0
37
264
1.47
1.28
2.2
1.7
1.7
1.4
%
1.24
31
237
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
8
36
2.26
1.25
4.5
2.1
0.2
0.4
u/ml
—
8
19
11
56
2.01
1.24
1.1
1.1
—
—
—
0
0
10
49
2.08
1.23
1.4
1.1
—
—
—
0
0
13
71
1.87
1.21
1.7
1.5
—
—
—
0
0
16
94
1.75
1.20
1.7
1.4
239.5
262.0
miu/ml
—
6
53
8
38
2.14
1.19
1.0
1.2
—
—
—
0
0
214
2004
1.38
1.19
19.6
12.8
39.6
40.2
%
0.53
157
1599
6
26
2.34
1.19
2.2
1.6
—
—
—
0
0
61
482
1.35
1.19
3.8
3.2
984.5
1048.3
ng/l
0.08
49
411
30
210
1.48
1.15
5.9
6.7
—
—
—
0
0
42
314
1.40
1.14
3.2
3.0
2.5
2.4
mmol/l
0.74
37
278
12
66
1.86
1.11
1.3
1.7
—
—
—
0
0
15
89
1.73
1.10
1.4
2.0
—
—
—
0
0
202
1883
1.33
1.10
5.9
4.9
38.4
39.1
mmol/mol
0.44
189
1770
49
379
1.36
1.10
1.5
1.3
17.5
30.0
iu/ml
0.92
11
134
5
21
2.41
1.09
2.4
1.7
—
—
—
0
0
5
21
2.41
1.09
2.8
1.2
—
—
—
0
0
7
32
2.22
1.09
2.1
1.2
—
—
—
0
0
7
32
2.22
1.09
1.3
1.0
—
—
—
0
0
162
1469
1.27
1.09
3.5
2.8
43.9
42.1
u/l
0.14
157
1397
108
938
1.26
1.03
4.5
3.9
—
—
—
0
0
57
456
1.32
1.02
2.5
2.1
—
—
—
0
0
40
304
1.37
1.00
3.6
2.7
3.0
3.1
e6/l
0.00
22
165
9
49
1.87
0.99
2.8
2.5
—
—
—
0
0
214
2020
1.34
0.99
4.8
3.9
5.8
5.8
mmol/l
0.15
196
1872
5
23
2.20
0.98
1.2
1.5
—
—
—
0
0
7
36
1.97
0.98
1.0
1.2
—
—
—
0
0
7
36
1.97
0.98
1.0
1.2
—
—
—
0
0
54
435
1.30
0.93
1.4
1.5
—
—
—
0
0
39
300
1.35
0.91
2.9
1.9
—
—
—
0
0
27
197
1.41
0.86
5.0
4.2
30.4
43.7
ug/l
0.13
21
161
19
129
1.51
0.86
1.5
1.3
385.8
317.8
u/ml
0.07
19
118
18
123
1.50
0.80
1.1
1.0
—
—
—
0
0
41
327
1.30
0.77
3.2
2.0
—
—
—
0
0
21
151
1.43
0.74
2.0
2.6
57.0
70.0
ml/min/173m2
—
10
61
29
221
1.35
0.74
4.6
4.1
31.7
31.9
%
0.03
21
150
13
84
1.58
0.73
4.6
7.8
23.0
24.5
mmol/l
1.09
13
79
195
1845
1.23
0.71
25.4
14.5
13.6
13.6
%
0.04
189
1819
5
26
1.94
0.71
2.8
1.3
—
—
—
0
0
14
94
1.52
0.68
7.4
4.8
25.5
25.1
mmol/l
0.11
14
94
221
2123
1.27
0.68
4.9
4.3
2.7
2.8
mmol/l
1.57
199
1986
45
370
1.26
0.68
1.6
1.3
1.5
11.4
u/ml
2.72
25
149
5
29
1.74
0.64
1.4
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.8
—
6.9
—
0
11
6
36
1.68
0.57
1.2
1.2
—
—
—
0
0
21
162
1.32
0.52
1.5
1.2
209.4
132.5
iu/ml
—
7
68
42
356
1.21
0.50
4.4
3.6
834.2
130.9
ng/l
0.58
27
255
20
155
1.31
0.48
4.4
5.2
1.2
1.3
mmol/l
0.15
20
146
13
94
1.40
0.47
1.5
1.4
—
—
—
0
0
215
2082
1.19
0.45
4.4
3.9
1.5
1.5
mmol/l
0.76
198
1950
28
337
0.81
0.44
4.3
4.5
21.0
20.9
%
—
10
142
8
58
1.39
0.42
1.5
1.7
43.4
38.3
nmol/l
—
8
58
0
16
0.00
0.41
0.0
1.1
—
33.8
—
0
9
0
16
0.00
0.41
0.0
1.0
—
526.3
—
0
9
61
546
1.15
0.40
1.5
1.6
1.3
1.4
mmol/l
0.23
48
476
10
71
1.42
0.40
1.2
1.2
—
—
—
0
0
10
71
1.42
0.40
1.2
1.2
—
—
—
0
0
10
136
0.72
0.38
1.4
1.5
—
—
—
0
0
215
2092
1.16
0.36
4.5
4.0
4.6
4.8
mmol/l
1.97
198
1967
207
2010
1.15
0.36
4.1
3.6
1.2
1.3
mmol/l
0.16
184
1875
6
44
1.37
0.34
1.2
2.1
—
—
—
0
0
6
47
1.28
0.32
1.3
1.1
3.6
3.6
mmol/l
—
6
42
6
47
1.28
0.32
1.5
1.2
—
—
—
0
0
22
259
0.84
0.30
3.5
2.7
0.6
0.7
ug/l
0.54
16
151
7
57
1.23
0.29
1.9
1.6
—
—
—
0
0
20
233
0.85
0.25
1.8
1.6
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.8
—
—
—
0
0
6
50
1.20
0.20
1.3
1.4
—
—
—
0
0
22
195
1.14
0.18
4.1
8.9
-0.4
1.2
mmol/l
1.23
16
151
16
138
1.17
0.18
1.2
1.3
—
—
—
0
0
7
62
1.13
0.17
1.1
1.7
—
—
—
0
0
45
428
1.06
0.10
4.3
4.5
1.4
2.7
ug/l
0.93
40
381
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
0.00
1.4
1.1
100.0
195.0
e6/l
—
5
44
0
8
0.00
0.00
0.0
1.8
—
886.8
—
0
8
9
90
1.00
0.00
1.8
2.3
1.1
1.2
%
—
9
90
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
23.1
—
0
8
0
7
0.00
0.00
0.0
1.0
—
10.0
—
0
7
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
1543.7
—
0
9
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_PIGMENTNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PIGMENTNAS | 1.073 [0.84, 1.36] | 0.563 |
| Birth year | 0.998 [0.99, 1.01] | 0.593 |
During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 1063 females with L12_PIGMENTNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PIGMENTNAS | 1.412 [1.05, 1.9] | 0.022 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 727 males with L12_PIGMENTNAS died.
Mortality risk
Mortality risk for people of age
years, who have L12_PIGMENTNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.112% | 0.303% |
| 5 | 0.65% | 1.706% |
| 10 | 1.707% | 4.032% |
| 15 | 3.279% | 7.374% |
| 20 | 5.701% | 11.872% |
Relationships between endpoints
↥Index endpoint: L12_PIGMENTNAS – Other and unspecified disorders of pigmentation
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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