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Other and unspecified disorders of pigmentation

DOID EFO Endpoint Browser PheWeb

L12_PIGMENTNAS

obsolete_incontinentia pigmenti achromians: a dermal melanocytic condition affecting the shoulder area. Nevus of Ito often occurs in association with nevus of Ota in the same patient but is much less common, although the true incidence is unknown.

Suggest a new description

Endpoint definition

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Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L81.8, L81.9
  • Hospital discharge: ICD-9 — 6950A|7090X
  • Cause of death: ICD-10 — L81.8, L81.9
  • Cause of death: ICD-9 — 6950A|7090X

2 out of 7 registries used, show all original rules.

276

4. Check minimum number of events

None

276

5. Include endpoints

None

276

6. Filter based on genotype QC (FinnGen only)

256

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2175 1280 875
Only index persons 1843 1136 707
Unadjusted period prevalence (%)
Whole population 0.03 0.04 0.02
Only index persons 0.04 0.04 0.03
Median age at first event (years)
Whole population 36.01 39.30 30.99
Only index persons 39.15 41.63 35.18

-FinnGen-

Key figures

All Female Male
Number of individuals 256 178 78
Unadjusted period prevalence (%) 0.05 0.06 0.04
Median age at first event (years) 49.23 47.72 52.66

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
275
Matched controls
2750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.9
ICD-10 Finland
Disorder of pigmentation, unspecified
+∞
174.0
148
*
L81.8
ICD-10 Finland
Other specified disorders of pigmentation
2107.1
135.3
120
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
12.4
68.3
78
85
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
10.1
71
323
L81.4
ICD-10 Finland
Other melanin hyperpigmentation
57.1
9.7
11
*
L04AX03
ATC
methotrexate; systemic
3.0
8.6
41
151
D07AC01
ATC
betamethasone; topical
2.2
8.5
108
631
L81.0
ICD-10 Finland
Postinflammatory hyperpigmentation
+∞
8.4
8
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
8.2
85
457
A07EC01
ATC
sulfasalazine; oral, rectal
3.3
8.2
32
105
J01DB01
ATC
cefalexin; oral
2.8
8.0
238
1925
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.4
7.9
29
91
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.4
7.4
61
297
P01BA02
ATC
hydroxychloroquine; oral
3.0
7.3
33
118
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.3
7.0
27
88
M79.6
ICD-10 Finland
Pain in limb
2.0
6.9
122
791
N02AX02
ATC
tramadol; systemic, rectal
2.0
6.9
117
748
D07AD01
ATC
clobetasol; topical
2.4
6.9
51
236
R60.0
ICD-10 Finland
Localized oedema
2.8
6.8
36
141
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
6.7
117
754
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
23.2
6.7
9
*
H02AB06
ATC
prednisolone; systemic
1.9
6.7
133
896
L43.8
ICD-10 Finland
Other lichen planus
12.7
6.6
11
9
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.9
6.4
30
110
M05BA04
ATC
alendronic acid; oral
3.3
6.2
24
78
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.6
6.2
39
167
H02AB07
ATC
prednisone; oral
2.5
6.2
41
180
N05BA04
ATC
oxazepam; oral
2.0
6.1
80
465

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
47
67
8.25
32.46
1.1
1.1
—
—
—
0
0
56
219
2.96
10.71
7.1
5.2
1.11
1.08
mmol/l
0.35
51
202
132
809
2.21
9.47
5.2
4.3
35.51
36.37
g/l
0.85
121
768
63
282
2.60
9.23
1.4
1.4
682.35
539.39
titre
0.19
17
66
157
1083
2.05
7.74
6.7
5.9
9.72
10.14
umol/l
0.42
147
1029
54
248
2.47
7.41
2.7
2.2
21.64
23.46
%
0.43
46
218
56
263
2.42
7.31
2.6
2.1
2.28
2.41
g/l
0.86
50
244
211
1649
2.20
7.13
9.9
6.9
75.32
75.74
u/l
0.06
194
1546
151
1052
1.97
6.97
10.1
5.8
—
—
—
0
0
150
1052
1.94
6.70
8.9
5.4
57.25
56.47
%
0.40
142
1000
57
280
2.31
6.70
2.2
1.5
—
—
—
0
0
82
467
2.08
6.66
2.5
2.0
3.01
3.05
mg/l
0.03
71
407
132
891
1.93
6.58
2.6
2.0
—
—
—
0
0
53
260
2.29
6.23
1.3
1.2
—
—
—
0
0
83
487
2.01
6.16
5.0
3.8
—
—
—
0
0
150
1072
1.88
6.13
4.8
3.4
0.00
0.00
estimate
-0.00
36
201
151
1084
1.87
6.06
4.9
3.4
0.00
0.00
estimate
-0.00
35
178
136
949
1.86
5.93
16.0
8.2
0.00
0.00
e9/l
0.67
112
768
141
998
1.85
5.85
9.6
5.6
0.74
0.67
%
0.75
132
938
149
1073
1.85
5.85
5.9
4.6
0.00
0.00
estimate
-0.00
34
185
53
269
2.20
5.72
1.2
1.2
—
—
—
0
0
144
1032
1.83
5.69
9.5
5.5
2.90
2.78
%
0.30
136
974
89
549
1.92
5.65
4.1
2.9
0.19
0.38
e6/l
1.09
68
402
144
1036
1.82
5.58
9.8
5.9
8.68
8.32
%
0.86
136
983
28
107
2.80
5.51
2.4
2.8
—
—
—
0
0
147
1068
1.81
5.48
9.4
5.6
28.25
29.05
%
0.49
140
1017
32
132
2.61
5.45
2.4
2.8
67.48
66.88
g/l
0.16
32
122
153
1128
1.80
5.40
9.8
5.6
1.93
1.99
e9/l
0.22
136
1022
88
553
1.87
5.22
4.1
2.8
—
—
—
0
0
101
664
1.82
5.18
3.5
3.2
2.34
2.35
mmol/l
0.20
90
595
149
1099
1.78
5.17
10.0
5.5
0.05
0.04
e9/l
3.11
130
974
255
2252
2.82
5.09
20.0
11.5
19.55
21.03
mg/l
0.34
210
1720
77
468
1.90
5.04
2.0
1.7
0.72
1.22
mg/l
2.23
52
360
148
1098
1.75
4.96
10.0
5.5
0.60
0.55
e9/l
1.85
130
976
110
752
1.77
4.89
5.1
3.5
20.04
109.12
e6/l
1.46
77
512
152
1144
1.73
4.78
10.5
6.0
0.19
0.18
e9/l
0.49
136
1029
86
555
1.80
4.60
6.3
3.6
0.00
0.02
estimate
0.50
32
184
166
1289
1.73
4.59
14.1
9.4
4.16
3.97
e9/l
0.57
149
1145
200
1642
1.80
4.48
6.0
3.8
12.33
10.39
mm/h
1.25
183
1537
209
1740
1.84
4.45
5.1
3.8
14.95
14.62
pmol/l
1.11
186
1606
186
1498
1.75
4.43
6.0
4.0
—
—
—
0
0
120
864
1.69
4.30
10.5
10.6
1.12
1.18
inr
0.41
44
251
129
949
1.68
4.25
7.2
6.4
1.22
1.22
mmol/l
0.01
106
827
92
618
1.73
4.24
4.5
2.9
15.46
59.60
e6/l
2.02
67
467
177
1416
1.70
4.22
5.9
4.1
138.60
220.15
e6/l
—
5
27
119
864
1.67
4.08
6.4
5.6
1.22
1.22
mmol/l
0.46
106
805
252
2259
2.38
4.04
19.8
12.7
139.39
139.77
mmol/l
1.65
244
2196
132
988
1.65
3.99
3.5
2.6
136.01
92.43
ug/l
1.26
120
926
252
2262
2.36
3.97
20.2
12.8
3.99
3.95
mmol/l
1.76
245
2195
64
396
1.80
3.87
1.9
1.6
—
—
—
0
0
76
495
1.74
3.86
4.6
3.3
—
—
—
0
0
84
564
1.70
3.82
2.0
2.0
137.27
196.93
u/l
0.83
79
538
12
29
4.28
3.75
5.8
4.0
—
—
—
0
0
71
458
1.74
3.72
1.5
1.4
21.87
21.62
nmol/l
0.04
59
395
82
551
1.70
3.71
1.4
1.3
1.79
1.44
u/ml
0.16
28
158
44
247
1.93
3.59
1.7
1.5
—
—
—
0
0
108
785
1.62
3.58
2.1
1.8
99.56
98.44
pmol/l
0.09
54
381
80
539
1.68
3.57
12.2
7.2
—
—
—
0
0
62
390
1.76
3.53
1.9
1.6
428.74
465.24
pmol/l
0.53
50
341
27
127
2.25
3.49
2.2
2.9
70.94
73.21
e9/l
0.09
20
98
36
191
2.02
3.44
2.5
2.9
1.90
1.76
%
0.27
30
177
33
173
2.03
3.26
2.0
1.5
—
—
—
0
0
72
484
1.66
3.21
1.4
1.4
2.15
2.28
g/l
0.26
47
309
39
220
1.90
3.14
1.6
1.4
—
—
—
0
0
10
25
4.11
3.11
2.9
2.6
—
—
—
0
0
17
68
2.60
3.10
5.4
1.7
—
—
—
0
0
83
584
1.60
3.07
4.0
3.0
6.36
7.57
mmol/l
2.23
67
503
92
664
1.58
3.06
2.5
2.3
67.39
58.11
u/l
0.46
85
617
174
1449
1.55
3.00
4.3
3.4
—
—
—
0
0
79
553
1.60
2.97
4.2
3.3
—
—
—
0
0
47
290
1.75
2.85
2.0
2.0
—
—
—
0
0
11
33
3.43
2.84
7.5
4.3
—
—
—
0
0
11
33
3.43
2.84
1.0
1.8
—
—
—
0
0
150
1219
1.51
2.84
5.0
4.4
6.49
6.50
mmol/l
0.01
144
1119
99
741
1.53
2.75
4.0
3.3
26.32
32.47
ng/l
0.41
64
458
12
40
3.09
2.73
1.5
1.2
—
—
—
0
0
71
494
1.59
2.72
2.2
1.9
—
—
—
0
0
28
149
1.98
2.68
4.3
3.3
—
—
—
0
0
26
135
2.02
2.66
6.6
3.7
1.22
1.22
mmol/l
0.14
21
124
81
586
1.54
2.61
5.9
3.7
7.37
7.40
ph
1.84
18
100
231
2082
1.68
2.59
6.3
4.5
1.72
1.86
mu/l
1.44
213
1932
58
391
1.61
2.52
4.3
2.5
492.34
557.82
mosm/kgh2o
1.60
53
337
11
37
3.05
2.52
1.1
1.1
—
—
—
0
0
83
612
1.51
2.43
3.4
2.7
—
—
—
0
0
73
524
1.54
2.42
4.2
3.1
49.36
180.22
mg/l
0.55
47
339
30
170
1.86
2.40
6.7
3.3
—
—
—
0
0
8
22
3.71
2.38
2.8
2.0
1.72
1.70
mmol/l
—
8
22
25
134
1.95
2.36
1.2
1.2
—
—
—
0
0
9
28
3.29
2.33
1.4
1.4
—
—
—
0
0
41
259
1.69
2.29
2.5
1.8
29.51
28.94
s
0.42
41
253
75
548
1.51
2.28
4.9
3.7
12.73
11.35
mg/mmol
0.08
45
344
7
18
3.96
2.26
1.9
1.6
33.86
31.00
pg
—
7
18
25
137
1.91
2.22
2.2
2.1
12.52
13.30
nmol/l
0.16
18
130
8
24
3.40
2.19
1.6
1.7
—
—
—
0
0
11
42
2.69
2.17
1.0
1.1
—
—
—
0
0
39
247
1.67
2.16
2.1
2.3
4.45
6.29
umol/l
1.62
32
212
24
131
1.91
2.16
1.2
1.2
—
—
—
0
0
9
31
2.97
2.09
4.7
7.8
—
—
—
0
0
256
2406
1.93
2.07
14.5
9.2
25.58
25.94
u/l
0.13
248
2333
6
15
4.06
2.05
1.0
1.3
—
—
—
0
0
9
32
2.87
2.02
1.0
1.4
—
—
—
0
0
7
21
3.39
1.98
1.6
2.1
—
—
—
0
0
8
27
3.02
1.95
1.4
1.3
—
—
—
0
0
9
33
2.78
1.95
9.6
4.5
8.52
9.29
kpa
—
9
33
9
33
2.78
1.95
9.6
4.5
5.36
5.21
kpa
—
9
33
254
2388
1.83
1.95
17.9
10.6
—
—
—
0
0
80
611
1.44
1.92
4.5
3.0
—
—
—
0
0
47
322
1.55
1.91
2.0
1.6
1000.05
1223.50
nmol/l
1.43
39
248
27
160
1.76
1.90
6.3
4.1
0.11
0.14
%
—
9
51
17
86
2.04
1.89
3.6
3.1
—
—
—
0
0
7
22
3.24
1.89
1.0
1.2
—
—
—
0
0
5
12
4.22
1.83
1.2
1.1
—
—
—
0
0
8
29
2.81
1.80
1.3
1.4
—
—
—
0
0
11
47
2.40
1.80
2.5
1.7
—
—
—
0
0
34
223
1.60
1.67
1.6
1.4
—
—
—
0
0
71
544
1.41
1.66
4.2
2.7
345.15
8475.21
umol/l
3.15
65
483
219
2009
1.44
1.66
24.5
14.1
15.24
14.64
%
0.68
213
1985
12
56
2.20
1.63
1.5
1.3
—
—
—
0
0
37
250
1.55
1.61
1.4
1.3
—
—
—
0
0
6
20
3.04
1.59
2.3
2.8
—
—
—
0
0
6
20
3.04
1.59
3.2
1.7
91.42
90.37
%
—
6
20
46
328
1.48
1.57
3.2
2.9
2.46
2.44
mmol/l
0.48
41
292
44
311
1.49
1.56
2.0
2.1
74.01
100.71
ug/g
0.50
35
239
7
27
2.63
1.52
1.9
1.9
72.91
58.43
%
—
7
27
16
88
1.87
1.45
2.6
1.8
—
—
—
0
0
7
29
2.45
1.40
1.7
1.4
—
—
—
0
0
44
319
1.45
1.39
3.4
2.6
3.05
3.06
e6/l
0.00
22
172
27
176
1.59
1.38
6.3
3.9
0.56
1.00
%
—
9
68
5
17
2.98
1.36
9.6
8.1
0.57
0.56
mmol/l
—
5
17
5
17
2.98
1.36
2.2
2.2
40.70
41.59
%
—
5
17
14
76
1.89
1.32
1.1
1.1
—
—
—
0
0
24
154
1.61
1.31
6.7
3.9
0.43
0.75
%
—
7
51
10
48
2.12
1.29
1.2
1.0
—
—
—
0
0
10
48
2.12
1.29
1.2
1.0
—
—
—
0
0
24
155
1.60
1.28
6.6
4.0
0.20
0.09
%
—
5
45
8
36
2.26
1.25
1.9
2.6
—
—
—
0
0
6
25
2.43
1.25
1.2
1.6
—
—
—
0
0
6
25
2.43
1.25
1.8
1.2
—
—
—
0
0
11
57
1.97
1.18
3.4
2.0
—
—
—
0
0
15
87
1.77
1.17
1.7
1.6
—
—
—
0
0
80
659
1.30
1.16
3.1
2.1
—
—
—
0
0
171
1550
1.27
1.14
3.5
2.8
43.65
42.61
u/l
0.08
165
1472
7
30
2.37
1.13
1.4
1.3
—
—
—
0
0
16
96
1.71
1.13
1.8
1.4
239.50
254.67
miu/ml
—
6
55
228
2149
1.36
1.10
4.8
4.0
5.78
5.83
mmol/l
0.25
209
1984
7
32
2.22
1.09
5.6
4.1
4.35
4.35
e9/l
—
7
32
29
204
1.47
1.08
4.9
4.2
29.12
42.23
ug/l
0.13
22
167
37
273
1.41
1.08
2.0
1.7
—
—
—
0
0
214
2002
1.31
1.07
5.9
4.9
38.43
39.09
mmol/mol
0.48
199
1876
7
34
2.09
1.03
5.6
4.1
58.43
53.76
%
—
7
34
22
148
1.53
1.01
1.6
1.4
—
—
—
0
0
21
140
1.54
1.01
1.4
1.3
351.65
309.35
u/ml
0.05
21
130
25
174
1.48
0.99
4.1
4.1
—
—
—
0
0
263
2554
1.68
0.96
28.6
17.2
40.21
40.40
%
0.27
253
2414
11
62
1.81
0.95
2.8
2.8
—
—
—
0
0
263
2555
1.67
0.95
29.3
17.2
6.78
6.61
e9/l
0.70
258
2492
6
27
2.25
0.94
2.2
1.3
—
—
—
0
0
263
2556
1.66
0.93
29.2
17.2
4.42
4.53
e12/l
2.82
258
2496
24
169
1.46
0.91
2.5
2.4
—
21.13
—
0
10
50
401
1.30
0.88
1.5
1.3
17.46
34.35
iu/ml
1.35
11
145
15
96
1.59
0.86
4.8
13.2
—
—
—
0
0
113
1003
1.21
0.83
2.9
2.4
—
—
—
0
0
20
279
0.69
0.80
1.1
1.3
—
—
—
0
0
24
174
1.42
0.80
1.5
1.2
184.38
125.66
iu/ml
—
8
74
28
209
1.38
0.79
6.5
5.9
105.79
104.09
mmol/l
1.36
28
209
52
627
0.79
0.79
1.6
1.5
—
—
—
0
0
235
2252
1.30
0.78
4.9
4.4
2.75
2.84
mmol/l
0.88
212
2108
15
99
1.54
0.77
8.0
5.5
25.32
25.25
mmol/l
0.02
15
99
5
25
2.02
0.73
3.6
3.5
—
—
—
0
0
12
76
1.61
0.73
1.3
1.2
—
—
—
0
0
25
187
1.37
0.71
1.2
1.2
—
—
—
0
0
9
58
1.57
0.70
1.4
1.7
45.00
37.60
nmol/l
—
9
58
47
387
1.26
0.69
1.5
1.3
1.43
11.95
u/ml
3.05
27
156
45
372
1.25
0.64
4.3
3.5
804.57
150.08
ng/l
0.55
28
263
20
147
1.39
0.63
1.4
1.3
—
45.47
—
0
9
22
165
1.36
0.62
4.3
5.3
1.29
1.39
mmol/l
0.16
22
160
229
2209
1.22
0.56
4.5
4.0
1.45
1.50
mmol/l
1.11
211
2070
6
39
1.55
0.53
1.2
2.0
—
—
—
0
0
13
92
1.43
0.51
7.2
1.4
—
—
—
0
0
20
154
1.32
0.50
6.4
6.0
—
—
—
0
0
22
172
1.30
0.50
1.1
1.3
—
—
—
0
0
221
2134
1.18
0.48
4.1
3.6
1.26
1.26
mmol/l
0.01
197
1992
7
47
1.50
0.48
1.9
1.2
—
—
—
0
0
229
2219
1.19
0.47
4.5
4.0
4.63
4.77
mmol/l
1.37
211
2088
14
103
1.38
0.46
1.1
1.1
—
—
—
0
0
14
104
1.36
0.44
1.6
2.2
—
—
—
0
0
5
33
1.52
0.41
1.4
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
258.44
—
0
9
8
60
1.34
0.40
5.3
2.5
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
2.95
—
0
14
64
577
1.14
0.38
1.5
1.6
1.29
1.36
mmol/l
0.27
49
499
9
123
0.72
0.36
1.1
1.1
—
—
—
0
0
12
91
1.33
0.34
2.0
2.2
0.72
0.66
%
0.15
12
91
14
109
1.30
0.34
6.4
1.4
—
—
—
0
0
10
74
1.36
0.32
1.2
1.2
—
—
—
0
0
14
110
1.29
0.32
6.8
1.5
—
—
—
0
0
14
113
1.25
0.27
8.5
1.4
—
—
—
0
0
23
267
0.85
0.27
3.5
2.7
0.58
0.74
ug/l
0.83
17
156
5
71
0.70
0.26
1.6
1.3
—
—
—
0
0
5
38
1.32
0.23
1.0
1.2
—
—
—
0
0
5
42
1.19
0.21
1.4
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
7.70
—
0
11
0
10
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
113.54
—
0
12
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
6
49
1.23
0.20
1.3
1.1
3.63
3.56
mmol/l
—
6
42
16
181
0.88
0.14
1.2
1.4
—
—
—
0
0
13
113
1.16
0.13
6.5
1.4
—
—
—
0
0
11
94
1.18
0.13
2.1
2.2
1.09
1.21
%
0.22
11
94
22
200
1.11
0.13
4.1
9.0
-0.35
1.28
mmol/l
1.29
16
156
10
116
0.86
0.12
5.7
2.4
0.00
0.08
e6/l
—
10
110
16
143
1.13
0.12
3.4
2.3
—
—
—
0
0
5
45
1.11
0.10
1.4
1.2
—
—
—
0
0
46
439
1.06
0.09
4.3
4.6
1.43
2.71
ug/l
0.98
41
392
6
57
1.05
0.08
1.3
1.2
392.00
395.10
mg/l
—
6
52
10
113
0.88
0.08
3.8
10.7
24.28
24.63
mmol/l
—
10
107
8
74
1.08
0.07
2.9
11.6
1.26
0.93
%
—
8
69
12
109
1.11
0.06
2.8
2.8
—
—
—
0
0
29
277
1.05
0.05
1.8
1.4
—
—
—
0
0
12
110
1.10
0.05
3.6
8.6
—
—
—
0
0
25
240
1.05
0.03
1.3
1.8
—
—
—
0
0
12
113
1.06
0.02
8.1
1.5
—
—
—
0
0
16
153
1.05
0.01
1.3
1.6
—
—
—
0
0
18
178
1.01
0.00
4.7
9.6
96.53
95.74
%
0.41
18
172
84
845
0.99
0.00
3.3
2.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
77
0.91
0.00
4.6
9.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.54
—
0
6
6
69
0.87
0.00
3.0
4.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
7
72
0.97
-0.00
3.1
11.9
1.46
1.53
%
—
7
66
0
7
0.00
-0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
1.22
—
0
5
0
7
0.00
-0.00
0.0
2.1
—
—
—
0
0
5
53
0.94
-0.00
1.4
1.1
100.00
187.39
e6/l
—
5
44
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
3.8
13.8
0.92
1.24
mmol/l
—
6
55
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
5
57
0.87
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
53
0.94
-0.00
1.4
1.0
2.60
3.07
e6/l
—
5
42
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PIGMENTNAS and mortality.

Females

Parameter HR [95% CI] p-value
L12_PIGMENTNAS 1.073 [0.84, 1.36] 0.563
Birth year 0.998 [0.99, 1.01] 0.593

During the follow-up period (1.1.1998 — 31.12.2019), 98 out of 1063 females with L12_PIGMENTNAS died.

Males

Parameter HR [95% CI] p-value
L12_PIGMENTNAS 1.412 [1.05, 1.9] 0.022
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 84 out of 727 males with L12_PIGMENTNAS died.

Mortality risk

Mortality risk for people of age

years, who have L12_PIGMENTNAS.

N-year risk Females Males
1 0.112% 0.303%
5 0.65% 1.706%
10 1.707% 4.032%
15 3.279% 7.374%
20 5.701% 11.872%

Relationships between endpoints

↥

Index endpoint: L12_PIGMENTNAS – Other and unspecified disorders of pigmentation

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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