No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
334 |
4. Check minimum number of eventsNone |
334 |
5. Include endpointsNone |
334 |
6. Filter based on genotype QC (FinnGen only) |
334 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L81
- Name in latin
- Purpura pigmentosa
Similar endpoints
↥List of similar endpoints to
Pigmented purpuric dermatosis
based on the number of shared cases.
Similar with more cases:
- Other disorders of pigmentation
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2176 | 1158 | 1011 |
| Only index persons | 2090 | 1132 | 958 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.03 | 0.03 | 0.03 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 59.25 | 60.79 | 57.46 |
| Only index persons | 59.00 | 60.61 | 57.08 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 334 | 189 | 145 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 59.58 | 59.39 | 59.83 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 298
- Matched controls
- 2978
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
+∞
323.0
298
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
15.3
60.4
107
105
D07AC01
ATC
betamethasone; topical
3.9
26.7
158
666
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.7
24.9
98
279
D69.0
ICD-10 Finland
Allergic purpura
+∞
23.2
22
*
E0000UV
ATC
NA
3.5
23.1
161
747
D07AB02
ATC
hydrocortisone butyrate; topical
3.3
19.3
126
536
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
+∞
18.9
18
*
D07AB08
ATC
desonide; topical
4.7
14.8
53
131
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
+∞
13.6
13
*
D07AC13
ATC
mometasone; topical
2.8
13.4
112
534
D07AD01
ATC
clobetasol; topical
3.3
11.5
64
231
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
11.2
11.5
21
20
E000001
ATC
NA
2.8
10.1
74
318
H02AB06
ATC
prednisolone; systemic
2.1
9.2
158
1028
S18
ICPC
Laceration/cut
2.2
9.2
140
865
D02AE01
ATC
carbamide; topical
4.5
8.2
28
67
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
3.2
8.0
44
154
J01DB01
ATC
cefalexin; oral
2.3
7.8
246
2001
D02AX
ATC
Other emollients and protectives
7.0
7.7
18
27
XQ848
NOMESCO Finland
Dermatological photography
8.4
7.7
16
20
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.8
7.5
48
189
S21
ICPC
Skin texture symptom/complaint
2.8
7.5
49
193
R06AX27
ATC
desloratadine; oral
2.2
7.4
84
447
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
+∞
7.3
7
*
J01MA02
ATC
ciprofloxacin; systemic
1.9
6.3
122
797
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.3
6.1
21
51
E000002
ATC
NA
2.7
6.1
42
171
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
44
90
5.48
21.04
1.4
1.7
—
68.0
—
0
5
227
1608
2.29
11.13
12.9
9.5
4.2
4.1
e9/l
0.14
216
1413
265
2086
2.31
8.89
5.9
4.1
12.5
12.3
mm/h
0.07
253
1908
182
1274
1.94
8.09
6.5
5.7
1.2
1.2
mmol/l
0.47
173
1150
269
2163
2.25
8.05
10.1
7.5
84.0
77.0
u/l
1.21
262
2008
193
1388
1.92
7.80
8.3
6.5
1.2
1.2
mmol/l
0.08
169
1172
52
228
2.52
7.75
2.4
3.7
67.1
66.6
g/l
0.15
45
210
152
1029
1.88
7.23
3.9
3.1
—
—
—
0
0
88
512
1.98
6.51
5.6
3.8
19.5
337.7
ng/l
1.86
73
405
61
310
2.18
6.47
2.3
1.9
—
—
—
0
0
25
82
3.21
6.34
1.7
2.2
—
—
—
0
0
61
314
2.15
6.26
2.4
1.9
—
—
—
0
0
75
419
2.02
6.19
2.2
1.8
29.7
29.2
s
0.28
69
407
61
317
2.13
6.10
5.1
6.8
1.8
1.2
mmol/l
0.94
50
257
17
45
3.93
5.89
1.1
1.3
—
—
—
0
0
211
1642
1.77
5.86
4.7
4.4
6.5
6.7
mmol/l
0.55
204
1530
115
752
1.81
5.85
1.9
1.6
1.4
1.4
mmol/l
0.10
100
635
16
41
4.05
5.78
4.1
2.8
4.7
4.5
e9/l
0.11
16
41
165
1204
1.73
5.70
5.5
4.5
36.0
35.7
g/l
0.34
158
1133
113
740
1.80
5.69
3.4
2.7
344.2
6231.1
umol/l
2.66
96
630
77
447
1.94
5.66
2.3
1.9
—
—
—
0
0
16
42
3.95
5.60
4.4
3.0
60.1
57.2
%
0.40
16
42
19
59
3.35
5.25
1.1
1.5
—
—
—
0
0
19
59
3.35
5.25
1.1
1.5
—
—
—
0
0
271
2307
1.93
5.23
28.3
17.4
14.0
13.7
%
2.74
266
2271
156
1144
1.68
5.12
3.2
2.7
124.2
127.2
ug/l
0.08
145
1053
317
2875
3.02
5.11
22.8
16.1
4.0
4.0
mmol/l
0.28
312
2791
155
1139
1.67
5.02
2.2
2.0
100.3
94.5
pmol/l
0.69
78
575
79
482
1.84
4.94
1.4
1.3
17.6
34.1
iu/ml
2.21
26
156
323
2968
3.68
4.92
15.1
10.4
26.4
26.1
u/l
0.15
318
2858
309
2779
2.50
4.87
21.7
13.9
19.7
22.9
mg/l
1.32
270
2202
155
1153
1.64
4.70
3.1
2.2
81.8
77.4
nmol/l
1.11
146
1025
180
1392
1.64
4.66
4.7
3.6
0.0
0.0
estimate
0.00
29
238
74
453
1.81
4.55
3.4
3.0
4.1
2.4
e6/l
0.53
45
238
177
1369
1.62
4.53
4.7
3.6
0.0
0.0
estimate
0.00
30
251
247
2090
1.70
4.31
4.7
3.8
15.2
14.8
pmol/l
1.51
229
1883
176
1375
1.59
4.21
6.4
4.9
0.0
0.0
estimate
0.50
33
251
96
650
1.67
4.11
2.5
2.1
2.8
3.0
mg/l
0.47
83
558
112
793
1.62
4.00
4.1
3.0
0.5
0.5
e6/l
0.05
93
588
21
82
2.67
3.97
3.3
2.8
—
—
—
0
0
18
65
2.87
3.92
1.3
1.6
3482.2
21354.3
e6/l
—
10
47
68
429
1.73
3.74
3.6
3.1
0.8
0.8
mmol/l
0.55
63
406
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
21
85
2.57
3.71
2.0
2.2
0.3
0.4
u/ml
—
10
45
14
46
3.13
3.57
1.1
1.1
154.3
42.7
iu/ml
—
6
6
95
672
1.58
3.33
1.7
1.6
21.6
21.2
nmol/l
0.11
87
575
86
596
1.60
3.28
1.2
1.2
0.8
1.2
u/ml
0.54
20
164
113
847
1.50
3.01
3.5
3.0
2922.6
1078.3
ng/l
0.53
102
717
15
57
2.71
3.00
1.5
1.6
—
—
—
0
0
12
40
3.07
3.00
1.6
1.7
—
—
—
0
0
305
2823
1.93
2.94
5.8
5.0
2.6
2.8
mmol/l
2.62
292
2590
15
58
2.66
2.91
1.1
1.2
—
—
—
0
0
119
908
1.48
2.88
4.2
3.1
29.9
31.0
u/l
0.19
114
864
13
47
2.84
2.85
1.2
1.1
—
—
—
0
0
24
119
2.10
2.74
2.5
2.8
7.3
7.6
g/l
0.22
17
94
24
119
2.10
2.74
2.5
2.8
—
—
—
0
0
24
119
2.10
2.74
2.5
2.8
4.0
3.6
g/l
0.76
16
89
60
398
1.62
2.72
1.4
1.4
—
—
—
0
0
13
49
2.72
2.65
1.5
1.6
—
—
—
0
0
13
49
2.72
2.65
1.2
1.4
—
—
—
0
0
22
108
2.11
2.58
2.4
3.0
3.0
3.2
g/l
0.86
17
91
280
2553
1.60
2.57
5.8
4.6
1.9
1.9
mu/l
0.04
266
2313
57
380
1.60
2.53
3.0
2.3
22.2
22.6
%
0.07
45
322
88
649
1.48
2.48
1.7
1.6
1.6
1.3
mg/l
0.23
69
494
8
21
3.88
2.48
1.1
1.2
—
—
—
0
0
8
21
3.88
2.48
1.1
1.2
—
—
—
0
0
70
493
1.53
2.45
3.3
2.7
1.1
1.0
e6/l
0.08
40
275
66
459
1.55
2.45
1.4
1.3
10.0
10.5
u/ml
0.03
28
172
298
2767
1.71
2.44
5.1
4.5
4.5
4.7
mmol/l
2.63
282
2547
122
961
1.42
2.43
4.3
3.4
2.4
2.4
mmol/l
0.05
115
841
8
22
3.70
2.38
1.1
1.2
—
—
—
0
0
8
22
3.70
2.38
1.1
1.2
—
—
—
0
0
8
22
3.70
2.38
1.1
1.2
—
—
—
0
0
72
515
1.51
2.35
1.9
1.7
1131.7
1191.9
nmol/l
0.24
55
386
11
41
2.74
2.30
1.7
1.3
—
—
—
0
0
12
47
2.61
2.29
1.4
1.6
—
—
—
0
0
6
13
4.68
2.28
1.2
2.0
—
—
—
0
0
6
13
4.68
2.28
2.7
1.7
—
—
—
0
0
6
13
4.68
2.28
2.7
2.3
1442.3
1560.0
u/ml
—
6
13
94
714
1.44
2.26
4.6
4.2
22.8
21.7
%
0.24
44
328
6
14
4.34
2.16
1.2
1.9
—
—
—
0
0
132
1072
1.38
2.15
4.4
3.7
—
—
—
0
0
13
55
2.42
2.15
1.4
1.3
—
40.3
—
0
7
295
2753
1.61
2.10
5.0
4.4
1.4
1.5
mmol/l
0.89
278
2524
292
2725
1.57
2.01
5.2
4.6
6.0
6.0
mmol/l
0.20
271
2488
61
438
1.48
1.95
1.5
1.4
—
—
—
0
0
6
16
3.80
1.94
1.0
1.1
—
—
—
0
0
0
50
0.00
1.90
0.0
1.5
—
—
—
0
0
0
50
0.00
1.90
0.0
1.5
—
—
—
0
0
0
50
0.00
1.90
0.0
1.5
—
—
—
0
0
50
347
1.52
1.88
33.4
21.5
1.2
1.3
inr
—
6
56
6
17
3.57
1.84
1.2
1.9
—
—
—
0
0
208
1847
1.33
1.77
3.0
3.0
50.2
48.1
u/l
0.11
202
1718
18
96
1.92
1.74
1.7
1.8
202.5
246.2
ug/l
0.25
18
91
5
13
3.89
1.72
1.0
1.4
—
—
—
0
0
187
1647
1.31
1.63
3.3
2.9
—
—
—
0
0
39
265
1.53
1.63
2.7
2.3
40.5
30.6
u/l
0.54
32
221
15
77
1.99
1.62
1.6
1.8
—
—
—
0
0
30
193
1.61
1.58
1.9
1.5
—
—
—
0
0
23
138
1.72
1.56
8.1
9.0
25.8
24.6
mmol/l
1.92
23
132
14
71
2.01
1.56
1.9
1.4
—
—
—
0
0
110
907
1.32
1.54
5.5
4.7
2.4
2.6
ug/l
0.16
101
817
23
139
1.70
1.53
2.7
3.3
4.7
4.5
pmol/l
0.35
16
127
7
27
2.63
1.52
1.7
1.3
—
—
—
0
0
6
21
2.89
1.51
1.2
1.7
—
—
—
0
0
6
21
2.89
1.51
1.2
1.2
—
—
—
0
0
278
2607
1.40
1.48
6.6
5.7
40.3
39.8
mmol/mol
0.38
264
2419
14
73
1.96
1.46
1.6
1.8
—
—
—
0
0
6
22
2.76
1.44
1.2
1.2
—
94.4
—
0
5
105
868
1.31
1.43
2.9
2.5
52.8
56.2
u/l
0.46
100
806
94
769
1.31
1.38
4.7
3.8
0.0
0.0
estimate
0.50
31
247
149
1294
1.27
1.38
3.6
4.1
—
—
—
0
0
15
82
1.87
1.38
1.0
1.2
—
—
—
0
0
268
2510
1.34
1.34
26.0
14.9
39.6
40.1
%
0.46
189
1796
24
153
1.61
1.33
1.1
1.2
54.1
169.2
iu/ml
—
6
64
6
25
2.42
1.25
1.0
1.1
—
—
—
0
0
25
164
1.57
1.24
2.8
1.7
—
—
—
0
0
281
2665
1.34
1.17
4.4
4.0
1.3
1.3
mmol/l
0.34
264
2429
7
33
2.14
1.06
1.4
1.8
—
—
—
0
0
12
67
1.82
1.06
4.0
2.4
1.8
1.5
mg/l
0.56
12
61
15
91
1.68
1.02
3.5
4.8
30.8
134.3
mg/l
—
10
76
15
91
1.68
1.02
3.4
4.9
27.0
32.9
mg/l
—
10
77
14
84
1.70
0.99
2.7
1.6
—
—
—
0
0
18
116
1.58
0.99
1.8
2.0
2.2
4.3
ug/l
0.32
18
109
0
31
0.00
0.97
0.0
3.2
—
68.3
—
0
31
9
52
1.75
0.93
1.8
1.9
—
—
—
0
0
6
28
2.16
0.92
1.0
1.3
275.7
301.4
pmol/l
—
6
22
27
364
0.72
0.87
5.3
4.5
34.1
31.8
%
0.45
21
232
23
162
1.45
0.87
1.8
1.4
—
—
—
0
0
12
72
1.69
0.86
1.4
1.3
—
—
—
0
0
70
586
1.25
0.86
1.9
1.8
458.1
438.1
pmol/l
0.18
58
497
6
31
1.95
0.85
1.5
1.7
—
—
—
0
0
11
66
1.69
0.79
1.2
1.9
—
—
—
0
0
13
82
1.61
0.79
1.1
1.3
168.2
270.6
miu/ml
—
5
34
6
34
1.78
0.76
1.0
1.1
—
—
—
0
0
11
67
1.66
0.76
1.1
1.0
—
1.2
—
0
12
5
24
2.10
0.75
1.0
1.1
—
—
—
0
0
5
24
2.10
0.75
1.0
1.0
—
—
—
0
0
5
25
2.01
0.73
1.2
1.6
—
—
—
0
0
12
76
1.60
0.72
2.7
1.6
—
—
—
0
0
5
26
1.94
0.71
1.2
1.0
—
—
—
0
0
5
26
1.94
0.71
1.2
1.3
—
—
—
0
0
16
111
1.46
0.67
3.0
2.0
—
—
—
0
0
7
43
1.64
0.67
1.7
1.7
—
—
—
0
0
5
29
1.73
0.64
1.2
3.0
—
—
—
0
0
12
79
1.54
0.63
1.1
1.5
—
—
—
0
0
120
1089
1.16
0.62
4.0
3.6
107.2
46.6
ng/l
0.68
85
771
0
20
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
2.3
—
5.1
—
0
7
34
276
1.26
0.57
4.4
3.3
—
—
—
0
0
9
61
1.49
0.54
1.6
1.4
—
—
—
0
0
17
126
1.37
0.52
2.9
3.2
36.1
1463.5
u/ml
0.70
12
108
9
65
1.40
0.51
1.2
1.4
—
—
—
0
0
75
667
1.16
0.50
2.4
2.2
—
—
—
0
0
272
2641
1.16
0.46
21.9
13.1
80.3
80.4
ml/min/173m2
0.02
242
2169
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
5
34
1.48
0.40
1.0
1.1
—
—
—
0
0
18
142
1.28
0.39
6.9
2.9
28.9
35.5
u/ml
0.24
18
136
9
71
1.27
0.36
8.3
2.3
24.8
24.9
mmol/l
—
9
57
5
76
0.65
0.36
1.0
1.4
—
—
—
0
0
6
43
1.40
0.35
2.7
1.9
—
—
—
0
0
11
82
1.35
0.34
1.2
1.1
—
—
—
0
0
31
358
0.85
0.33
10.9
6.9
—
—
—
0
0
11
85
1.30
0.28
4.1
3.4
3.9
3.9
mmol/l
0.01
11
77
15
122
1.24
0.27
2.3
3.5
24.1
24.6
mmol/l
0.30
15
112
8
67
1.20
0.26
1.4
1.1
—
—
—
0
0
9
74
1.22
0.25
1.6
1.3
—
—
—
0
0
6
82
0.73
0.24
1.8
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
21
240
0.87
0.21
3.9
2.1
—
—
—
0
0
5
43
1.17
0.21
1.6
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
10
82
1.23
0.17
3.5
2.1
—
—
—
0
0
24
215
1.13
0.17
5.2
3.0
43.9
67.0
ml/min/173m2
—
8
102
8
97
0.82
0.14
2.9
3.3
25.1
25.0
mmol/l
—
8
92
23
250
0.91
0.11
2.4
3.4
5.8
5.8
kpa
0.05
23
244
33
310
1.07
0.10
3.8
4.4
7.0
9.8
ug/l
0.35
26
259
5
45
1.11
0.10
1.2
1.0
—
—
—
0
0
9
104
0.86
0.06
1.8
1.7
—
—
—
0
0
13
141
0.92
0.05
1.6
1.4
—
—
—
0
0
22
232
0.94
0.05
2.2
1.6
—
—
—
0
0
31
323
0.96
0.05
1.8
1.7
1.6
1.5
%
0.41
26
278
13
140
0.93
0.04
2.2
2.4
1.3
1.2
%
0.24
13
140
13
136
0.95
0.00
1.0
1.0
—
—
—
0
0
11
109
1.01
0.00
1.7
1.9
—
—
—
0
0
52
519
1.00
0.00
2.8
3.0
1.1
0.8
ug/l
0.66
34
334
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
1.3
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
22
220
1.00
0.00
3.8
1.9
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
9
90
1.00
0.00
2.2
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
22.8
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint L12_PIGPURPDERM and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PIGPURPDERM | 0.86 [0.69, 1.07] | 0.17 |
| Birth year | 0.995 [0.99, 1.0] | 0.213 |
During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 992 females with L12_PIGPURPDERM died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_PIGPURPDERM | 1.032 [0.84, 1.26] | 0.763 |
| Birth year | 0.985 [0.98, 0.99] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 152 out of 884 males with L12_PIGPURPDERM died.
Mortality risk
Mortality risk for people of age
years, who have L12_PIGPURPDERM.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.118% | 0.185% |
| 5 | 0.529% | 1.12% |
| 10 | 1.299% | 2.87% |
| 15 | 2.442% | 5.331% |
| 20 | 4.198% | 9.065% |
Relationships between endpoints
↥Index endpoint: L12_PIGPURPDERM – Pigmented purpuric dermatosis
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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