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Pigmented purpuric dermatosis

DOID EFO Endpoint Browser PheWeb

L12_PIGPURPDERM

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L81.7
  • Cause of death: ICD-10 — L81.7

2 out of 7 registries used, show all original rules.

363

4. Check minimum number of events

None

363

5. Include endpoints

None

363

6. Filter based on genotype QC (FinnGen only)

353

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L81
Name in latin
Purpura pigmentosa

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2176 1158 1011
Only index persons 2090 1132 958
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 59.25 60.79 57.46
Only index persons 59.00 60.61 57.08

-FinnGen-

Key figures

All Female Male
Number of individuals 353 203 150
Unadjusted period prevalence (%) 0.07 0.07 0.07
Median age at first event (years) 60.27 59.88 60.79

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
363
Matched controls
3630
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L81.7
ICD-10 Finland
Pigmented purpuric dermatosis
+∞
307.7
363
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
11.2
93.5
119
151
L30.9
ICD-10 Finland
Dermatitis, unspecified
4.7
42.3
138
421
D07AC01
ATC
betamethasone; topical
4.0
37.7
206
897
D07AB02
ATC
hydrocortisone butyrate; topical
3.3
26.4
161
713
E0000UV, ,
ATC
3.2
26.2
206
1057
D07AB08
ATC
desonide; topical
3.9
20.2
69
208
D69.0
ICD-10 Finland
Allergic purpura
42.7
19.8
24
6
D07AC13
ATC
mometasone; topical
2.7
18.0
140
681
D07AD01
ATC
clobetasol; topical
3.1
16.9
86
332
L95.9
ICD-10 Finland
Vasculitis limited to skin, unspecified
166.9
15.6
16
*
D69.2
ICD-10 Finland
Other nonthrombocytopenic purpura
37.7
14.6
18
5
I83.9
ICD-10 Finland
Varicose veins of lower extremities without ulcer or inflammation
3.3
13.7
57
194
I83.1
ICD-10 Finland
Varicose veins of lower extremities with inflammation
10.7
13.2
25
25
D02AX
ATC
Other emollients and protectives
5.9
13.1
24
43
H02AB06
ATC
prednisolone; systemic
2.2
12.1
195
1255
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
4.2
11.0
30
76
XQ848
NOMESCO Finland
Dermatological photography
5.2
10.2
21
42
S18
ICPC
Laceration/cut
2.0
10.0
185
1228
E000002, ,
ATC
2.9
9.6
49
187
I87.2
ICD-10 Finland
Venous insufficiency (chronic)(peripheral)
2.8
9.5
53
212
E000001, ,
ATC
2.3
9.3
86
435
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
4.2
9.2
25
63
D07BB04
ATC
hydrocortisone butyrate and antiseptics; topical
2.5
8.6
58
254
S21
ICPC
Skin texture symptom/complaint
2.3
8.1
65
309
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
22.6
8.1
11
5
UJF32
NOMESCO Finland
Coloscopy
2.0
8.0
109
638
S08
ICPC
Skin colour change
3.6
8.0
27
80
S29
ICPC
Skin symptom/complaint other
2.2
7.8
80
421
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.1
7.8
33
113
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
7.6
165
1124
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
2.0
7.5
96
547
L30.0
ICD-10 Finland
Nummular dermatitis
3.9
7.5
22
59
L82
ICD-10 Finland
Seborrhoeic keratosis
2.2
7.5
71
362
L17
ICPC
Foot/toe symptom/complaint
1.9
7.1
117
728
J01DB01
ATC
cefalexin; oral
2.2
7.0
304
2553
R06AE07
ATC
cetirizine; oral
1.8
7.0
163
1128
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
6.9
179
1275
WZC00
NOMESCO Finland
Treatment plan or consultation
1.8
6.9
135
884
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.7
146
987
SBB10
NOMESCO Finland
Dental impressions
3.0
6.6
30
107
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.6
6.5
40
168
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
71.1
6.4
7
*
R06AX27
ATC
desloratadine; oral
1.9
6.4
102
625
L04AB01
ATC
etanercept; parenteral
11.3
6.3
11
10
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
5.9
6.2
16
28
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
6.2
132
883
L01BA01
ATC
methotrexate; systemic
4.2
6.2
16
39
H11.3
ICD-10 Finland
Conjunctival haemorrhage
3.4
6.1
22
68
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
6.1
52
253
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
5.7
6.1
16
29

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
69
105
7.88
45.07
1.2
1.2
—
—
—
0
0
109
393
3.53
24.78
1.4
1.4
448.89
504.37
titre
0.16
27
87
227
1383
2.71
18.62
8.5
6.0
—
—
—
0
0
235
1489
2.64
17.26
8.2
5.6
0.64
0.58
e9/l
1.13
217
1293
235
1494
2.62
17.06
8.3
5.6
0.05
0.04
e9/l
0.94
217
1302
235
1524
2.54
15.88
8.3
5.6
1.83
1.97
e9/l
0.70
220
1365
236
1547
2.50
15.36
8.6
5.7
0.22
0.18
e9/l
1.84
221
1369
214
1350
2.43
15.06
8.3
5.6
0.71
0.67
%
0.62
207
1256
218
1404
2.38
14.38
8.8
5.9
9.13
8.58
%
1.65
211
1317
216
1399
2.34
13.88
8.4
5.6
3.24
2.76
%
2.46
211
1308
219
1432
2.33
13.69
8.5
5.7
26.60
27.63
%
0.79
211
1346
213
1420
2.21
12.13
8.2
5.5
57.79
57.36
%
0.21
207
1338
247
1752
2.28
12.00
12.6
9.2
4.20
4.11
e9/l
0.13
231
1538
78
372
2.40
9.72
1.3
1.4
—
—
—
0
0
59
247
2.66
9.66
2.4
3.6
67.49
66.59
g/l
0.35
52
227
288
2280
2.27
9.28
5.9
4.0
12.70
12.32
mm/h
0.15
276
2088
199
1381
1.98
9.18
6.4
5.5
1.21
1.22
mmol/l
1.20
192
1256
200
1397
1.96
8.98
16.8
12.9
1.33
1.26
inr
0.43
59
408
293
2356
2.26
8.76
10.0
7.4
82.47
77.46
u/l
0.82
285
2195
51
209
2.68
8.69
2.1
3.3
—
—
—
0
0
208
1506
1.89
8.04
8.4
6.3
1.21
1.22
mmol/l
0.15
186
1290
144
926
1.92
8.04
5.5
3.9
7.40
7.40
ph
0.12
20
167
144
942
1.88
7.52
3.1
3.0
7.27
7.58
mmol/l
0.37
128
784
232
1767
1.87
7.37
4.8
4.3
6.49
6.68
mmol/l
1.00
224
1646
183
1296
1.83
7.36
5.5
4.4
36.15
35.68
g/l
0.57
175
1222
91
513
2.03
7.34
1.4
1.3
25.69
35.31
iu/ml
0.41
31
167
263
2088
1.94
7.31
5.7
4.1
—
—
—
0
0
143
945
1.85
7.15
3.7
3.7
7.17
7.24
mg/mmol
0.01
82
584
66
334
2.19
7.04
5.1
6.6
1.82
1.16
mmol/l
0.99
54
266
266
2145
1.90
6.73
4.5
3.9
—
—
—
0
0
123
797
1.82
6.42
3.3
2.7
342.35
6619.36
umol/l
3.09
106
683
94
561
1.91
6.35
5.4
3.8
18.84
320.32
ng/l
1.96
78
443
307
2619
2.12
6.33
27.5
16.8
15.11
15.12
%
0.01
302
2585
133
888
1.79
6.26
3.2
3.1
1374.63
347.20
mg/l
0.71
77
560
78
449
1.94
5.83
2.2
1.8
29.75
29.26
s
0.31
72
436
121
800
1.77
5.81
5.2
4.3
—
—
—
0
0
57
293
2.12
5.81
4.9
7.0
95.62
96.19
%
0.42
57
284
338
3029
2.68
5.70
21.7
13.7
19.13
22.76
mg/l
1.76
293
2384
134
919
1.73
5.62
3.1
3.1
—
—
—
0
0
123
824
1.75
5.61
1.9
1.6
1.38
1.38
mmol/l
0.02
108
695
178
1322
1.68
5.53
14.2
9.4
0.00
0.00
e9/l
0.54
151
1085
18
52
3.59
5.52
1.1
1.4
—
—
—
0
0
171
1261
1.67
5.43
3.1
2.2
81.78
77.37
nmol/l
1.26
162
1122
164
1198
1.67
5.39
4.0
3.4
6.33
5.74
ph
—
9
97
168
1235
1.67
5.39
2.2
1.9
98.32
94.98
pmol/l
0.35
83
619
345
3137
3.01
5.39
22.8
15.9
3.97
3.98
mmol/l
0.06
340
3046
106
689
1.76
5.33
4.3
3.7
—
—
—
0
0
21
69
3.17
5.31
1.4
1.6
3280.15
20809.25
e6/l
1.24
13
51
196
1504
1.66
5.29
4.9
3.6
0.00
0.00
estimate
-0.00
31
257
113
751
1.73
5.25
9.4
6.9
—
—
—
0
0
344
3134
2.87
5.14
18.6
13.1
—
—
—
0
0
351
3234
3.58
5.11
15.1
10.2
26.31
26.13
u/l
0.07
346
3115
16
45
3.67
5.10
1.3
1.4
—
—
—
0
0
169
1261
1.64
5.01
3.2
2.6
124.99
124.55
ug/l
0.01
157
1158
192
1482
1.63
4.94
4.8
3.6
0.00
0.00
estimate
0.50
35
292
192
1485
1.62
4.88
6.5
4.8
0.00
0.00
estimate
0.50
35
272
39
185
2.24
4.84
4.2
6.5
24.48
24.36
mmol/l
0.07
39
177
16
47
3.52
4.80
4.1
3.2
4.65
4.50
e9/l
0.11
16
47
134
951
1.65
4.80
4.1
3.2
34.30
123.25
e6/l
0.70
111
735
106
709
1.70
4.75
2.5
2.1
2.71
3.00
mg/l
0.57
92
607
16
48
3.44
4.66
4.4
3.4
60.13
57.52
%
0.36
16
48
40
195
2.18
4.65
2.8
4.3
—
—
—
0
0
34
156
2.30
4.57
3.3
8.3
—
—
—
0
0
79
493
1.77
4.50
3.3
3.0
4.00
2.42
e6/l
0.51
46
260
123
866
1.64
4.49
3.9
3.0
0.49
0.46
e6/l
0.03
99
647
97
645
1.69
4.40
1.3
1.2
0.76
1.34
u/ml
0.95
26
180
354
3347
3.33
4.31
31.7
20.5
40.17
40.36
%
0.25
317
3121
74
460
1.76
4.26
3.4
3.1
0.80
0.82
mmol/l
0.79
68
436
269
2299
1.66
4.25
4.7
3.7
15.19
14.76
pmol/l
1.90
250
2072
44
231
2.03
4.24
2.5
2.8
10.31
10.53
g/l
0.10
37
209
77
489
1.73
4.11
1.4
1.3
3.73
9.78
u/ml
1.25
33
186
145
1083
1.56
4.05
5.3
3.7
114.59
83.22
e6/l
0.39
114
783
22
88
2.60
3.96
1.7
1.9
21.59
21.15
s
0.16
17
82
154
1174
1.54
3.89
2.4
2.1
—
—
—
0
0
117
840
1.58
3.85
3.8
3.0
—
—
—
0
0
126
924
1.56
3.76
3.4
3.0
2660.53
1073.05
ng/l
0.51
115
789
103
725
1.59
3.66
1.6
1.6
21.07
20.95
nmol/l
0.03
95
622
67
424
1.71
3.61
1.8
1.7
—
—
—
0
0
90
618
1.61
3.54
3.5
2.9
537.19
549.13
mosm/kgh2o
0.24
80
531
40
218
1.94
3.49
1.1
1.1
—
—
—
0
0
135
1020
1.52
3.47
4.1
3.4
2.35
2.35
mmol/l
0.25
127
895
98
690
1.58
3.46
1.8
1.6
1.48
1.31
mg/l
0.19
76
527
82
555
1.62
3.41
1.8
1.7
1145.88
1177.62
nmol/l
0.12
64
416
333
3078
1.99
3.33
5.8
5.0
2.63
2.77
mmol/l
2.23
319
2829
43
245
1.86
3.29
3.0
2.7
79.49
69.71
e9/l
0.73
29
196
13
43
3.10
3.28
1.2
1.5
—
—
—
0
0
94
664
1.56
3.25
4.9
4.0
1.01
1.02
kg/l
1.22
11
75
84
579
1.59
3.23
1.5
1.5
2.86
2.59
g/l
0.43
48
356
25
118
2.20
3.18
2.6
5.2
1.79
1.50
%
0.70
25
113
53
326
1.73
3.15
1.5
1.5
—
—
—
0
0
51
312
1.74
3.09
1.7
1.5
—
—
—
0
0
14
51
2.82
3.02
1.2
1.3
—
—
—
0
0
19
83
2.36
2.89
1.1
1.2
—
—
—
0
0
7
13
5.47
2.88
2.4
2.5
1322.57
1560.15
u/ml
—
7
13
17
71
2.46
2.84
1.2
2.0
—
—
—
0
0
53
337
1.67
2.80
3.1
2.6
2.06
1.80
%
0.74
45
307
326
3023
1.77
2.79
5.1
4.4
4.52
4.68
mmol/l
2.28
309
2791
62
413
1.60
2.74
2.8
2.2
23.79
22.51
%
0.22
49
352
14
55
2.61
2.64
6.9
2.6
—
—
—
0
0
58
386
1.60
2.57
1.3
1.6
—
—
—
0
0
13
50
2.66
2.56
1.1
1.1
154.33
42.50
iu/ml
—
6
6
5
7
7.22
2.55
1.4
1.3
—
—
—
0
0
323
3003
1.69
2.53
5.0
4.4
1.46
1.48
mmol/l
0.45
305
2763
9
26
3.52
2.50
2.6
1.7
30.57
38.10
%
—
9
26
12
45
2.72
2.47
2.4
1.9
1.60
1.53
mmol/l
0.18
12
45
48
308
1.64
2.46
1.5
1.6
—
—
—
0
0
36
214
1.76
2.43
4.4
4.3
0.00
0.15
%
0.66
13
68
6
12
5.06
2.41
2.0
4.5
53.25
49.83
%
—
6
12
304
2797
1.53
2.36
5.8
4.5
1.94
1.91
mu/l
0.13
290
2540
33
193
1.78
2.36
2.0
1.7
2.73
1.43
g/l
0.41
27
178
80
583
1.48
2.35
2.7
3.0
2.47
2.45
mmol/l
0.62
74
516
320
2980
1.62
2.34
5.2
4.6
5.98
5.97
mmol/l
0.04
298
2724
282
2559
1.46
2.32
29.5
18.1
332.18
332.33
g/l
0.09
282
2545
307
2835
1.54
2.30
6.5
5.7
39.93
39.91
mmol/mol
0.02
292
2630
8
23
3.53
2.28
1.1
1.2
—
—
—
0
0
41
259
1.66
2.24
3.7
3.1
—
—
—
0
0
35
212
1.72
2.23
4.1
4.3
0.12
0.41
%
1.68
12
75
10
35
2.91
2.22
1.0
1.2
—
—
—
0
0
45
292
1.62
2.22
2.5
2.3
40.72
30.32
u/l
0.66
36
246
59
409
1.53
2.20
1.3
1.2
—
—
—
0
0
165
1388
1.35
2.07
2.5
2.6
—
—
—
0
0
38
241
1.64
2.06
4.3
4.3
0.20
1.03
%
3.09
15
94
105
824
1.39
2.05
4.9
3.8
0.00
0.00
estimate
0.50
33
267
17
83
2.10
2.04
1.0
1.1
—
—
—
0
0
5
11
4.59
1.94
1.2
1.2
—
—
—
0
0
9
33
2.77
1.94
1.6
1.3
—
—
—
0
0
6
16
3.79
1.94
1.2
1.4
—
—
—
0
0
36
229
1.64
1.93
1.5
1.4
—
—
—
0
0
117
945
1.35
1.89
2.9
2.5
52.27
60.68
u/l
0.84
111
880
15
72
2.13
1.89
2.7
5.9
—
—
—
0
0
0
46
0.00
1.72
0.0
1.5
—
—
—
0
0
0
46
0.00
1.72
0.0
1.5
—
—
—
0
0
0
48
0.00
1.71
0.0
1.5
—
—
—
0
0
18
97
1.90
1.69
1.7
1.8
202.46
244.26
ug/l
0.23
18
91
118
971
1.32
1.65
5.4
4.8
2.35
2.60
ug/l
0.18
109
874
11
49
2.28
1.65
1.1
1.1
—
—
—
0
0
62
462
1.41
1.62
1.7
1.8
—
—
—
0
0
32
209
1.58
1.57
1.4
1.4
—
—
—
0
0
12
57
2.14
1.56
1.2
1.1
—
—
—
0
0
7
27
2.62
1.52
2.0
2.6
—
—
—
0
0
11
51
2.19
1.52
5.9
2.4
—
—
—
0
0
6
21
2.89
1.51
1.2
1.1
—
—
—
0
0
6
21
2.89
1.51
2.7
1.2
—
—
—
0
0
49
355
1.44
1.50
1.4
1.3
—
—
—
0
0
9
37
2.47
1.49
2.2
1.6
31.89
32.14
pg
—
9
37
138
1176
1.28
1.46
4.3
3.7
93.62
45.62
ng/l
0.60
99
838
17
95
1.83
1.45
1.6
1.6
—
—
—
0
0
222
2007
1.27
1.44
3.1
2.9
50.13
48.01
u/l
0.13
216
1868
40
282
1.47
1.41
1.6
1.5
—
—
—
0
0
9
40
2.28
1.41
2.0
8.3
7.37
6.85
mmol/l
—
9
34
26
167
1.60
1.39
1.1
1.2
54.13
154.40
iu/ml
—
6
71
9
41
2.22
1.38
1.2
1.5
—
—
—
0
0
17
97
1.79
1.37
3.6
5.3
27.46
132.30
mg/l
0.97
12
80
17
97
1.79
1.37
3.5
5.3
27.25
33.08
mg/l
0.55
12
81
99
815
1.30
1.36
4.3
3.1
—
—
—
0
0
33
226
1.51
1.34
4.6
4.4
0.00
0.13
%
2.17
11
79
307
2906
1.37
1.34
4.4
4.0
1.26
1.29
mmol/l
0.44
289
2658
14
76
1.88
1.31
1.2
1.2
—
—
—
0
0
6
24
2.52
1.31
1.2
1.3
—
—
—
0
0
35
245
1.47
1.29
6.0
6.6
—
—
—
0
0
8
37
2.19
1.22
1.8
2.9
—
—
—
0
0
5
19
2.65
1.22
1.0
1.8
—
—
—
0
0
5
19
2.65
1.22
1.6
1.2
—
—
—
0
0
48
361
1.38
1.21
3.8
2.1
151.48
135.25
ug/g
0.15
39
289
20
125
1.63
1.20
1.7
2.0
2.13
3.99
ug/l
0.31
20
117
27
182
1.52
1.20
3.2
2.3
4.76
5.44
e9/l
0.18
21
150
6
26
2.33
1.19
1.0
1.4
—
—
—
0
0
10
50
2.03
1.17
4.2
2.1
—
—
—
0
0
8
39
2.07
1.16
2.3
1.8
—
—
—
0
0
8
39
2.07
1.16
2.3
1.9
—
—
—
0
0
78
637
1.29
1.14
1.9
1.8
451.11
437.94
pmol/l
0.12
64
536
5
21
2.40
1.09
2.0
2.2
12.78
13.22
%
—
5
21
11
59
1.89
1.08
1.5
1.5
—
—
—
0
0
37
273
1.40
1.06
1.6
1.4
—
—
—
0
0
15
90
1.70
1.05
2.5
3.3
—
—
—
0
0
19
122
1.59
1.05
1.1
1.1
—
—
—
0
0
34
248
1.41
1.04
4.3
3.3
—
—
—
0
0
23
155
1.52
1.04
2.7
3.2
4.67
4.47
pmol/l
0.34
16
141
28
197
1.46
1.03
4.0
2.8
—
—
—
0
0
7
35
2.02
1.00
1.0
1.1
—
—
—
0
0
13
76
1.74
1.00
3.8
2.3
1.70
1.47
mg/l
0.42
13
70
94
798
1.24
1.00
1.3
1.4
—
—
—
0
0
47
365
1.33
0.99
6.6
5.9
103.96
104.08
mmol/l
0.06
47
365
23
157
1.50
0.99
2.3
2.2
—
—
—
0
0
5
23
2.19
0.98
1.0
1.0
—
—
—
0
0
0
30
0.00
0.97
0.0
1.6
—
4.15
—
0
21
10
54
1.88
0.97
1.3
1.1
—
—
—
0
0
6
27
2.24
0.94
2.3
2.6
—
—
—
0
0
16
102
1.59
0.92
2.0
3.8
0.19
0.12
g/l
—
7
39
6
30
2.02
0.87
2.0
1.3
—
—
—
0
0
8
46
1.76
0.83
3.8
2.8
—
—
—
0
0
6
32
1.89
0.82
1.8
1.3
—
—
—
0
0
6
33
1.83
0.79
1.0
1.2
—
—
—
0
0
12
74
1.64
0.79
1.3
1.4
—
—
—
0
0
5
98
0.50
0.79
1.6
1.2
—
—
—
0
0
9
55
1.65
0.74
1.6
1.2
—
—
—
0
0
7
38
1.86
0.74
1.1
1.2
—
—
—
0
0
5
25
2.01
0.73
1.2
1.2
—
—
—
0
0
5
25
2.01
0.73
1.2
1.0
—
—
—
0
0
13
84
1.57
0.73
1.3
1.4
—
—
—
0
0
13
85
1.55
0.70
1.1
1.3
168.20
298.58
miu/ml
—
5
36
11
69
1.61
0.69
6.6
3.3
7.43
7.42
ph
0.03
11
60
9
59
1.54
0.69
1.7
1.6
—
—
—
0
0
7
42
1.68
0.68
1.1
1.1
1.45
1.45
g/l
—
7
37
21
154
1.39
0.66
6.2
2.6
27.33
49.71
u/ml
0.67
21
148
107
956
1.17
0.66
2.8
2.3
—
—
—
0
0
19
137
1.41
0.66
2.8
3.2
32.48
1329.29
u/ml
0.70
14
119
13
87
1.51
0.64
1.3
1.4
—
—
—
0
0
5
29
1.73
0.64
1.0
1.3
—
—
—
0
0
13
88
1.50
0.61
1.3
1.4
—
—
—
0
0
18
131
1.39
0.60
2.6
1.8
—
—
—
0
0
13
89
1.48
0.58
1.3
1.4
—
—
—
0
0
13
89
1.48
0.58
1.3
1.4
—
—
—
0
0
9
61
1.49
0.54
1.4
2.4
—
—
—
0
0
10
66
1.53
0.53
1.3
1.2
13.56
8.60
u/l
—
5
51
23
291
0.78
0.52
4.1
4.4
—
—
—
0
0
20
155
1.31
0.48
4.1
3.4
—
—
—
0
0
12
85
1.43
0.47
2.3
1.4
279.20
305.97
ug/g
—
5
52
12
87
1.39
0.42
4.4
4.3
—
—
—
0
0
8
57
1.41
0.42
1.0
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
16.2
—
—
—
0
0
11
149
0.73
0.41
1.6
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.9
—
—
—
0
0
42
365
1.17
0.38
1.5
1.3
—
—
—
0
0
22
179
1.24
0.38
5.3
3.1
7.39
7.42
ph
—
5
18
14
107
1.32
0.37
17.4
10.2
—
—
—
0
0
15
121
1.25
0.29
1.7
3.0
—
—
—
0
0
10
78
1.29
0.24
2.8
2.7
—
—
—
0
0
15
179
0.83
0.23
2.0
1.4
—
—
—
0
0
5
38
1.32
0.23
1.2
3.0
3.22
3.44
nmol/l
—
5
38
5
40
1.25
0.22
2.4
1.9
83.60
90.24
%
—
5
40
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
5
41
1.22
0.22
1.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
131.18
—
0
11
0
10
0.00
0.21
0.0
1.2
—
1.32
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
24
211
1.15
0.21
1.5
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
4.4
—
—
—
0
0
6
49
1.23
0.20
3.0
1.3
—
—
—
0
0
6
52
1.16
0.19
3.2
1.5
57.85
62.63
%
—
6
52
95
911
1.06
0.16
4.0
3.8
—
—
—
0
0
26
286
0.90
0.15
1.3
1.4
—
—
—
0
0
9
106
0.85
0.13
2.7
3.6
25.02
24.96
mmol/l
—
9
101
35
327
1.08
0.12
3.7
4.4
6.84
9.40
ug/l
0.33
27
275
13
116
1.13
0.09
4.1
4.4
—
—
—
0
0
6
58
1.04
0.08
1.2
1.3
—
—
—
0
0
7
83
0.84
0.07
1.4
1.3
—
—
—
0
0
55
564
0.97
0.04
2.8
3.0
1.03
0.80
ug/l
0.58
37
360
14
150
0.93
0.04
3.0
2.5
1.51
1.18
%
0.55
14
150
25
240
1.04
0.03
1.4
1.4
—
—
—
0
0
17
161
1.06
0.03
1.6
1.3
—
—
—
0
0
12
127
0.94
0.01
4.3
3.2
—
—
—
0
0
108
1071
1.01
0.01
3.0
2.9
—
—
—
0
0
14
134
1.05
0.00
1.0
1.1
—
—
—
0
0
27
265
1.02
0.00
3.5
3.2
5.96
5.80
kpa
0.47
27
256
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
5.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
3.39
—
0
8
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
17
170
1.00
-0.00
1.5
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PIGPURPDERM and mortality.

Females

Parameter HR [95% CI] p-value
L12_PIGPURPDERM 0.86 [0.69, 1.07] 0.17
Birth year 0.995 [0.99, 1.0] 0.213

During the follow-up period (1.1.1998 — 31.12.2019), 120 out of 992 females with L12_PIGPURPDERM died.

Males

Parameter HR [95% CI] p-value
L12_PIGPURPDERM 1.032 [0.84, 1.26] 0.763
Birth year 0.985 [0.98, 0.99] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 152 out of 884 males with L12_PIGPURPDERM died.

Mortality risk

Mortality risk for people of age

years, who have L12_PIGPURPDERM.

N-year risk Females Males
1 0.118% 0.185%
5 0.529% 1.12%
10 1.299% 2.87%
15 2.442% 5.331%
20 4.198% 9.065%

Relationships between endpoints

↥

Index endpoint: L12_PIGPURPDERM – Pigmented purpuric dermatosis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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