Chronic crepitant synovitis/bursitis of hand and wrist/periarthritis of wrist

M13_CHRONSYNOVITISHANDWRIST

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M70.0, M70.1, M77.2
  • Hospital discharge: ICD-9 7264A
  • Cause of death: ICD-10 M70.0, M70.1, M77.2
  • Cause of death: ICD-9 7264A

2 out of 7 registries used, show all original rules.

530

4. Check minimum number of events

None

530

5. Include endpoints

None

530

6. Filter based on genotype QC (FinnGen only)

530

Control definitions (FinnGen only)

Control exclude
M13_SOFTTISSUE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3653 2118 1522
Only index persons 3478 2036 1442
Unadjusted period prevalence (%)
Whole population 0.05 0.06 0.04
Only index persons 0.07 0.07 0.06
Median age at first event (years)
Whole population 51.39 52.07 50.41
Only index persons 50.83 51.70 49.59

-FinnGen-

Key figures

All Female Male
Number of individuals 530 351 179
Unadjusted period prevalence (%) 0.11 0.12 0.08
Median age at first event (years) 52.06 51.74 52.69

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
484
Matched controls
4841
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M70.0
ICD-10 Finland
Chronic crepitant synovitis of hand and wrist
2123.9
323.0
312
*
M70.1
ICD-10 Finland
Bursitis of hand
+∞
105.1
97
*
M77.2
ICD-10 Finland
Periarthritis of wrist
+∞
71.7
67
*
NDM40
NOMESCO Finland
Discission of sheath of tendon of wrist or hand
+∞
62.9
59
*
M79.6
ICD-10 Finland
Pain in limb
4.8
49.3
214
691
NBG15
NOMESCO Finland
Acromioplastia, arthroscopic
72.5
46.2
52
8
M75.1
ICD-10 Finland
Rotator cuff syndrome
5.3
40.2
141
349
M79.0
ICD-10 Finland
Rheumatism, unspecified
94.2
39.5
43
5
G56.0
ICD-10 Finland
Carpal tunnel syndrome
5.9
37.7
117
249
M65.3
ICD-10 Finland
Trigger finger
22.6
35.2
51
25
M25.5
ICD-10 Finland
Pain in joint
3.8
34.2
187
693
N02AX02
ATC
tramadol; systemic, rectal
3.3
33.0
248
1171
M19.0
ICD-10 Finland
Primary arthrosis of other joints
7.1
30.2
78
128
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
17.0
30.1
48
31
N03AX16
ATC
pregabalin; oral
3.6
27.7
150
537
M75.0
ICD-10 Finland
Adhesive capsulitis of shoulder
14.3
24.7
42
32
NDM20
NOMESCO Finland
Excision of synovial ganglion of wrist or hand
131.5
23.8
25
*
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
8.9
23.1
50
62
M54.5
ICD-10 Finland
Low back pain
2.9
23.0
185
856
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
4.8
22.6
81
196
M67.4
ICD-10 Finland
Ganglion
9.0
22.0
47
57
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.6
21.8
251
1424
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
6.2
21.5
60
108
H02AB06
ATC
prednisolone; systemic
2.5
21.1
251
1441
M70.6
ICD-10 Finland
Trochanteric bursitis
4.4
20.7
81
213
M01AC06
ATC
meloxicam; systemic, rectal
2.6
20.7
211
1108
J01AA02
ATC
doxycycline; systemic
3.0
20.7
406
3070
NDL52
NOMESCO Finland
Tenosynovectomy of hand
43.8
20.6
25
6
M01AE02
ATC
naproxen; oral, rectal
2.5
20.4
296
1876
N03AX12
ATC
gabapentin; oral
3.6
19.3
95
306
N06AX21
ATC
duloxetine; oral
4.4
18.8
72
185
M65.4
ICD-10 Finland
Radial styloid tenosynovitis [de Quervain]
16.1
18.2
29
19
M54.4
ICD-10 Finland
Lumbago with sciatica
3.4
17.9
94
318
NBT60
NOMESCO Finland
Forcible manipulation of humeroscapular joint
69.3
17.8
20
*
Z01.8
ICD-10 Finland
Other specified special examinations
2.9
17.7
131
557
M79.7
ICD-10 Finland
Fibromyalgia
17.8
17.6
27
16
M01AH05
ATC
etoricoxib; oral
2.3
17.3
303
2032
N02AJ06
ATC
codeine and paracetamol; systemic
2.4
17.0
189
1012
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
3.7
16.8
78
238
NDM10
NOMESCO Finland
Palmar fasciotomy of hand
+∞
16.8
16
*
M03BA52
ATC
carisoprodol, combinations excl. psycholeptics; oral
8.0
16.8
38
51
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.3
16.5
63
161
M17.1
ICD-10 Finland
Other primary gonarthrosis
2.9
16.5
116
476
R51.80
ICD-10 Finland
Headache
3.4
16.5
89
303
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.8
16.4
56
128
M01AX17
ATC
nimesulide; oral
2.6
16.0
135
620
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
16.0
188
1027
ZXA00
NOMESCO Finland
Right side
2.5
15.7
152
750
M65.9
ICD-10 Finland
Synovitis and tenosynovitis, unspecified
14.4
15.7
26
19
M01AE03
ATC
ketoprofen; systemic, rectal
2.3
15.6
202
1154
J01DB01
ATC
cefalexin; oral
2.6
15.6
407
3235
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
3.3
15.4
85
296
J01DA01
ATC
[U] cefalexin; systemic
2.2
15.4
322
2285
M54.9
ICD-10 Finland
Dorsalgia, unspecified
4.0
15.2
64
179
J01FF01
ATC
clindamycin; systemic
2.5
15.1
147
728
M77.1
ICD-10 Finland
Lateral epicondylitis
4.9
15.0
50
111
S18
ICPC
Laceration/cut
2.2
14.8
208
1228
M01AX05
ATC
glucosamine; oral
2.7
14.8
111
473
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
14.8
151
763
N06AA09
ATC
amitriptyline; systemic
3.8
14.7
66
195
M13.9
ICD-10 Finland
Arthritis, unspecified
4.7
14.6
51
119
M72.0
ICD-10 Finland
Palmar fascial fibromatosis [Dupuytren]
28.1
14.4
19
7
L08
ICPC
Shoulder symptom/complaint
2.8
14.3
99
402
A02BC02
ATC
pantoprazole; systemic
2.1
14.2
317
2271
ZXA05
NOMESCO Finland
Left side
2.4
14.0
142
710
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
3.6
13.9
64
194
M48.0
ICD-10 Finland
Spinal stenosis
3.6
13.7
65
201
M03BX02
ATC
tizanidine; oral
2.1
13.7
313
2249
R03AC02
ATC
salbutamol; inhalant
2.1
13.6
262
1750
A07EC01
ATC
sulfasalazine; oral, rectal
4.0
13.6
56
154
A02BC03
ATC
lansoprazole; oral
2.3
13.4
155
826
M02AA10
ATC
ketoprofen; topical
2.8
13.3
93
378
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
4.6
13.1
46
108
M01AH02
ATC
rofecoxib; oral
3.1
13.1
77
277
R07.4
ICD-10 Finland
Chest pain, unspecified
2.4
13.1
135
678
P01BA02
ATC
hydroxychloroquine; oral
3.6
13.1
60
181
N02BE01
ATC
paracetamol; systemic, rectal
2.5
12.9
417
3449
A02BC05
ATC
esomeprazole; systemic
2.1
12.6
204
1256
M01AB05
ATC
diclofenac; systemic, rectal
2.1
12.6
329
2455
M70.2
ICD-10 Finland
Olecranon bursitis
9.3
12.4
25
28
A06AC01
ATC
ispaghula (psylla seeds); oral
2.3
12.3
132
676
M79.1
ICD-10 Finland
Myalgia
3.3
12.2
63
209
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
3.2
11.9
63
213
K30
ICD-10 Finland
Functional dyspepsia
3.2
11.8
63
214
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.6
11.8
54
163
NBA30
NOMESCO Finland
Exploration of joint of shoulder or upper arm, arthroscopic
16.9
11.7
18
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
11.6
202
1270
ACC51
NOMESCO Finland
Release of median nerve
4.2
11.5
44
113
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
4.9
11.5
37
80
A02BC01
ATC
omeprazole; systemic
2.2
11.3
139
755
J45.9
ICD-10 Finland
Asthma, unspecified
2.5
11.2
95
428
C03CA01
ATC
furosemide; systemic
2.2
11.0
128
676
M70.4
ICD-10 Finland
Prepatellar bursitis
16.0
10.9
17
11
J01FA06
ATC
roxithromycin; oral
2.0
10.8
198
1257
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.3
10.7
23
29
G44.2
ICD-10 Finland
Tension-type headache
2.7
10.6
76
312
M15.9
ICD-10 Finland
Polyarthrosis, unspecified
4.4
10.6
38
92
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.5
10.6
89
399
M01AH01
ATC
celecoxib; oral (coxibs)
2.4
10.5
101
486
Z3226
NOMESCO Finland
Physiotherapist
2.4
10.5
94
436
M02AA07
ATC
piroxicam; topical
2.0
10.5
179
1105
7264A
ICD-9 Finland
Peripheral enthesopathies and allied syndromes, Enthesopathy of wrist and carpus
+∞
10.4
10
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.9
10.3
250
1750
N06AX16
ATC
venlafaxine; oral
2.6
10.3
77
323
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
10.3
92
424
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
3.3
10.3
53
175
UJF32
NOMESCO Finland
Coloscopy
2.2
10.3
125
672
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.8
10.2
70
279
NGA30
NOMESCO Finland
Exploration of knee joint, arthroscopic
5.1
10.1
31
64
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.1
10.1
39
102
N06AX11
ATC
mirtazapine; oral
2.0
10.0
153
902
S80.0
ICD-10 Finland
Contusion of knee
4.0
10.0
39
103
R42
ICD-10 Finland
Dizziness and giddiness
2.3
9.9
103
514
M72.2
ICD-10 Finland
Plantar fascial fibromatosis
3.9
9.8
39
105
NF1AA
NOMESCO Finland
Hip X-ray examination
3.4
9.5
46
145
R60.0
ICD-10 Finland
Localized oedema
2.8
9.5
60
229
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.2
9.4
110
577
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.3
9.4
20
25
M65.8
ICD-10 Finland
Other synovitis and tenosynovitis
12.7
9.4
16
13
M09AX01
ATC
hyaluronic acid; parenteral
4.6
9.4
32
74
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
6.6
9.4
23
36
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.2
9.3
103
525
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
9.3
134
769
H02AB07
ATC
prednisone; oral
2.5
9.3
76
335
J01MA02
ATC
ciprofloxacin; systemic
1.9
9.2
180
1156
M79.2
ICD-10 Finland
Neuralgia and neuritis, unspecified
14.0
9.2
15
11
SPAT1202
SPAT
Intra-articular injection
5.3
9.2
27
53
M01AX01
ATC
nabumetone; oral
4.9
9.2
29
62
R4120
NOMESCO Finland
Occupational therapy
4.0
9.1
36
96
L12
ICPC
Hand/finger symptom/complaint
2.7
9.1
66
271
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.4
9.1
78
354
AA1AD
NOMESCO Finland
CT of head and brain
2.2
9.0
103
533
M01AE01
ATC
ibuprofen; systemic, rectal
2.3
9.0
430
3754
M77.4
ICD-10 Finland
Metatarsalgia
4.8
8.9
29
64
M23.2
ICD-10 Finland
Derangement of meniscus due to old tear or injury
2.7
8.9
62
248
M70.7
ICD-10 Finland
Other bursitis of hip
7.0
8.9
21
31
J01DA09
ATC
[U] cefadroxil; inhalant, oral
2.0
8.9
139
818
L15
ICPC
Knee symptom/complaint
2.2
8.9
101
523
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
8.8
229
1612
A07AA02
ATC
nystatin; oral
3.7
8.8
38
110
M71.1
ICD-10 Finland
Other infective bursitis
50.9
8.7
10
*
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.5
8.6
40
123
N02AA05
ATC
oxycodone; systemic
2.5
8.6
70
309
M77.9
ICD-10 Finland
Enthesopathy, unspecified
6.2
8.5
22
37
X58
ICD-10 Finland
Exposure to other specified factors
2.5
8.5
67
290
A01
ICPC
Pain general/multiple sites
3.4
8.5
40
124
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.3
8.5
86
422
M54.3
ICD-10 Finland
Sciatica
3.7
8.5
36
103
H02AB04
ATC
methylprednisolone; systemic
2.3
8.4
79
374
9502
FHL
Tendon splitting (De Quervain, click finger)
91.6
8.4
9
*
M71.0
ICD-10 Finland
Abscess of bursa
91.6
8.4
9
*
S46.0
ICD-10 Finland
Injury of muscle(s) and tendon(s) of the rotator cuff of shoulder
3.9
8.4
34
93
SPAT1153
SPAT
Removal of sutures
1.9
8.4
151
936
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
8.4
137
820
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.1
8.4
47
164
NFM20
NOMESCO Finland
Excision of bursa of hip or thigh
+∞
8.4
8
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.7
8.3
57
228
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.1
8.3
99
524
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.8
8.3
55
215
SAA01
NOMESCO Finland
Simple examination of mouth
1.8
8.2
326
2596
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.5
8.1
37
112
M18.0
ICD-10 Finland
Primary arthrosis of first carpometacarpal joints, bilateral
12.0
8.1
14
12
ND1BG
NOMESCO Finland
Wrist and hand MRI examination with high intensity magnet
17.5
8.1
12
7
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
8.1
42
141
J45.1
ICD-10 Finland
Nonallergic asthma
3.3
8.1
39
124
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.1
7.9
42
143
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
6.3
7.9
20
33
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.7
7.9
258
1922
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
7.9
184
1237
M01AB55
ATC
diclofenac, combinations; oral
3.2
7.9
40
132
C10AA01
ATC
simvastatin; oral
1.8
7.8
194
1330
A02BA02
ATC
ranitidine; systemic
2.1
7.8
95
503
R05
ICD-10 Finland
Cough
2.1
7.8
91
476
NBG10
NOMESCO Finland
Acromioplastia
15.3
7.7
12
8
M76.8
ICD-10 Finland
Other enthesopathies of lower limb, excluding foot
15.3
7.7
12
8
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
7.6
7.7
17
23
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.2
7.7
40
134
M03BC01
ATC
orphenadrine (citrate); systemic
2.0
7.7
112
638
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
7.7
80
396
M54.6
ICD-10 Finland
Pain in thoracic spine
3.3
7.6
37
118
NDA30
NOMESCO Finland
Exploration of joint of wrist or hand, arthroscopic
18.7
7.6
11
6
L13
ICPC
Hip symptom/complaint
2.3
7.6
71
335
NB1AE
NOMESCO Finland
Shoulder ultrasound examination
10.3
7.6
14
14
Z00.0
ICD-10 Finland
General medical examination
2.1
7.5
84
431
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
7.5
130
790
A02BA04
ATC
nizatidine; systemic
2.9
7.5
45
167
NBL00
NOMESCO Finland
Suture or reinsertation of rotator cuff of shoulder
6.1
7.4
19
32
NCM20
NOMESCO Finland
Excision of synovial ganglion of elbow or forearm
81.3
7.4
8
*
SPAT1263
SPAT
Sampling
1.7
7.4
194
1349
M54.2
ICD-10 Finland
Cervicalgia
3.3
7.4
36
116
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.8
7.4
46
173
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
7.4
84
432
M76.0
ICD-10 Finland
Gluteal tendinitis
11.1
7.3
13
12
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.6
7.3
54
226
A10AA01
ATC
NA
5.3
7.3
21
41
C07AB07
ATC
bisoprolol; oral
1.7
7.3
208
1478
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.7
7.3
187
1289
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
7.3
76
378
L03
ICPC
Low back symptom/complaint
2.0
7.3
101
566
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
3.3
7.2
35
112
A01AB09
ATC
miconazole; local oral
2.6
7.2
52
212
L86
ICPC
Back syndrome with radiating pain
3.7
7.2
30
85
L17
ICPC
Foot/toe symptom/complaint
1.9
7.2
107
615
R4110
NOMESCO Finland
Physiotherapy
1.9
7.2
120
720
NGF35
NOMESCO Finland
Plastic operation of joint cartilage of knee
4.5
7.1
24
56
N06AX26
ATC
vortioxetine; oral
3.7
7.1
29
81
2402
FHL
External neurolysis of the nerve and possible alteration of the pathway (nerve pressure)
10.2
7.1
13
13
P01AB01
ATC
metronidazole; oral, rectal
1.7
7.1
191
1335
R52.2
ICD-10 Finland
Other chronic pain
5.1
7.1
21
43
H04AA01
ATC
glucagon; nasal, parenteral
7.2
7.0
16
23
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
4.4
7.0
24
57
L40.0
ICD-10 Finland
Psoriasis vulgaris
4.0
7.0
26
67
WX110
NOMESCO Finland
Local anesthesy
1.7
7.0
311
2500
M01AH03
ATC
valdecoxib; oral
3.1
7.0
36
121
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.7
7.0
184
1275
M20.1
ICD-10 Finland
Hallux valgus (acquired)
2.8
7.0
44
167
R53
ICD-10 Finland
Malaise and fatigue
2.0
7.0
93
512
WX204
NOMESCO Finland
Axillary plexus blockaced
4.9
6.9
21
44
M53.1
ICD-10 Finland
Cervicobrachial syndrome
2.5
6.9
54
233
H02BX01
ATC
methylprednisolone, combinations; systemic
3.7
6.9
28
78
L16
ICPC
Ankle symptom/complaint
2.6
6.9
48
195
P03
ICPC
Feeling depressed
2.8
6.8
43
162
J01FA09
ATC
clarithromycin; systemic
1.8
6.8
148
963
L11
ICPC
Wrist symptom/complaint
2.9
6.8
39
140
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
6.8
34
112
P01
ICPC
Feeling anxious/nervous/tense
2.7
6.7
44
172
J02AC01
ATC
fluconazole; systemic
1.7
6.7
192
1359
NDL54
NOMESCO Finland
Tenolysis of hand
22.9
6.7
9
*
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.9
6.7
26
70
M01AC01
ATC
piroxicam; systemic, rectal
2.3
6.7
63
300
NB1CG
NOMESCO Finland
Shoulder and humerus extensive MRI examination with high intensity magnet
10.2
6.6
12
12
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.3
6.6
59
271
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.7
6.6
45
179
G56.2
ICD-10 Finland
Lesion of ulnar nerve
5.2
6.6
19
38
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
3.6
6.5
28
82
M19.1
ICD-10 Finland
Post-traumatic arthrosis of other joints
5.5
6.5
18
34
SPAT1229
SPAT
Assessment of need for aid
2.8
6.5
39
145
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
6.3
6.5
16
26
WX320
NOMESCO Finland
Spinalanesthesy
1.9
6.5
100
579
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.4
6.5
22
52
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.1
6.5
34
116
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
3.8
6.5
26
72
NC1BG
NOMESCO Finland
Elbow MRI examination with high intensity magnet
70.7
6.4
7
*
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.0
6.4
91
512
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
6.4
175
1218
C07AB02
ATC
metoprolol; systemic
2.0
6.4
89
499
B01AC04
ATC
clopidogrel; oral
2.2
6.4
63
306
M75.8
ICD-10 Finland
Other shoulder lesions
5.6
6.4
17
31
NE1CG
NOMESCO Finland
Pelvic, hip and femur extensive MRI examination with high intensity magnet
6.1
6.3
16
27
Z00.8
ICD-10 Finland
Other general examinations
2.9
6.3
37
135
M70.5
ICD-10 Finland
Other bursitis of knee
11.2
6.3
11
10
NB1AD
NOMESCO Finland
Shoulder CT examination
11.2
6.3
11
10
WX120
NOMESCO Finland
Intravenous local anesthesy of arm
9.4
6.3
12
13
M20.2
ICD-10 Finland
Hallux rigidus
4.4
6.3
21
49
M19.8
ICD-10 Finland
Other specified arthrosis
4.4
6.3
21
49
KMAK
NOMESCO Finland
NA
1.6
6.3
235
1780
R1240
NOMESCO Finland
Social assessment of need and possibilities of rehabilitation
18.3
6.3
9
5
NCL22
NOMESCO Finland
Myotomy or tenotomy of elbow or forearm
+∞
6.3
6
*
M17.3
ICD-10 Finland
Other post-traumatic gonarthrosis
7.2
6.3
14
20
R51.81
ICD-10 Finland
Facial pain NOS
7.2
6.3
14
20
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
6.2
44
180
J01CA04
ATC
amoxicillin; systemic
1.7
6.2
374
3210
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.0
6.2
84
464
M19.9
ICD-10 Finland
Arthrosis, unspecified
4.3
6.2
21
50
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.5
6.2
47
201
C10AA05
ATC
atorvastatin; oral
1.7
6.2
164
1132
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.5
6.1
27
81
310
Kela drug reimbursment
Orlistat, sibutramine and other major and expensive medicines used to treat obesity
8.8
6.1
12
14
Z3231
NOMESCO Finland
Registered nurse
1.8
6.1
123
779
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.8
6.1
24
66
N05AH04
ATC
quetiapine; oral
2.1
6.0
69
354
A06AD11
ATC
lactulose; oral
2.2
6.0
61
299
SPAT1216
SPAT
Assessment of functional ability
2.1
6.0
69
355
R01BA52
ATC
pseudoephedrine, combinations; oral
1.7
6.0
151
1023
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.5
6.0
26
77

Mortality – FinRegistry

Association

Association between endpoint M13_CHRONSYNOVITISHANDWRIST and mortality.

Females

Parameter HR [95% CI] p-value
M13_CHRONSYNOVITISHANDWRIST 1.108 [0.94, 1.3] 0.21
Birth year 0.995 [0.99, 1.0] 0.231

During the follow-up period (1.1.1998 — 31.12.2019), 269 out of 1878 females with M13_CHRONSYNOVITISHANDWRIST died.

Males

Parameter HR [95% CI] p-value
M13_CHRONSYNOVITISHANDWRIST 1.158 [0.99, 1.36] 0.074
Birth year 0.985 [0.98, 0.99] 0.002

During the follow-up period (1.1.1998 — 31.12.2019), 238 out of 1368 males with M13_CHRONSYNOVITISHANDWRIST died.

Mortality risk

Mortality risk for people of age

years, who have M13_CHRONSYNOVITISHANDWRIST.

N-year risk Females Males
1 0.098% 0.258%
5 0.652% 1.328%
10 1.581% 3.134%
15 2.973% 5.697%
20 5.195% 10.039%

Relationships between endpoints

Index endpoint: M13_CHRONSYNOVITISHANDWRIST – Chronic crepitant synovitis/bursitis of hand and wrist/periarthritis of wrist

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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