This is a non-core endpoint: only basic statistics are computed.
See these related core endpoints for full statistics:
Symptoms and signs involving appearance and behaviour
R18_SYMPTOMS_SIGNS_INVOLVI_APPEA_BEHVI
No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
319 |
4. Check minimum number of eventsNone |
319 |
5. Include endpointsNone |
319 |
6. Filter based on genotype QC (FinnGen only) |
319 |
Control definitions (FinnGen only)
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF4
- Parent code in ICD-10
- R4[0-6]
- Name in latin
- Symptomata et signa ad habitum corporis et modum se gerendi pertinentia
Similar endpoints
↥List of similar endpoints to
Symptoms and signs involving appearance and behaviour
based on the number of shared cases.
Similar with more cases:
- Symptoms and signs involving cognition, perception, emotional state and behaviour
- Symptoms, signs and abnormal clinical and laboratory findings, not elsewhere classified
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
This endpoint is excluded from FinRegistry analyses (omitted endpoint).
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 319 | 206 | 113 |
| Unadjusted period prevalence (%) | 0.06 | 0.07 | 0.05 |
| Median age at first event (years) | 49.38 | 44.88 | 57.58 |
-FinnGen-
Age distribution of first events
-FinnGen-
Year distribution of first events
-FinnGen-
Cumulative Incidence Function
Not a core endpoint, no data to show.
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 291
- Matched controls
- 2908
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R46.8
ICD-10 Finland
Other symptoms and signs involving appearance and behaviour
+∞
226.8
187
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
16.8
55.4
93
79
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
52.8
47.4
56
13
R56.8
ICD-10 Finland
Other and unspecified convulsions
15.8
40.9
69
56
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
16.0
31.5
52
39
AA1AD
NOMESCO Finland
CT of head and brain
5.5
29.8
103
263
R55
ICD-10 Finland
Syncope and collapse
8.0
27.3
66
103
R46.6
ICD-10 Finland
Undue concern and preoccupation with stressful events
+∞
26.5
25
*
N05AX08
ATC
risperidone; systemic
8.4
24.4
56
80
R42
ICD-10 Finland
Dizziness and giddiness
7.2
24.3
63
108
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
21.9
24.1
35
18
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.2
23.7
55
80
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.8
22.9
55
84
N05AH04
ATC
quetiapine; oral
4.7
22.5
87
241
G40.9
ICD-10 Finland
Epilepsy, unspecified
14.4
22.4
38
30
N03AG01
ATC
valproic acid; systemic, rectal
9.0
21.6
47
61
R46.2
ICD-10 Finland
Strange and inexplicable behaviour
+∞
21.1
20
*
R41.0
ICD-10 Finland
Disorientation, unspecified
225.4
20.9
21
*
N03AX09
ATC
lamotrigine; oral
10.0
20.2
41
47
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
31.5
20.0
26
9
N05BA04
ATC
oxazepam; oral
3.7
19.4
102
369
N06AX16
ATC
venlafaxine; oral
4.6
19.0
73
198
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.7
18.7
70
184
N03AX14
ATC
levetiracetam; systemic
19.7
18.2
27
15
N05AH03
ATC
olanzapine; systemic
7.3
17.9
44
69
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
5.1
17.4
59
139
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.6
16.3
60
154
N06AX11
ATC
mirtazapine; oral
3.1
16.2
118
529
SPAT1249
SPAT
Treatment-related counselling outside office
2.9
16.1
151
796
N03AE01
ATC
clonazepam; systemic
7.1
15.4
38
60
N03AF02
ATC
oxcarbazepine; oral
10.3
15.4
30
32
F29
ICD-10 Finland
Unspecified nonorganic psychosis
9.0
14.7
31
38
R46.0
ICD-10 Finland
Very low level of personal hygiene
+∞
14.7
14
*
R46.4
ICD-10 Finland
Slowness and poor responsiveness
+∞
14.7
14
*
N06AB10
ATC
escitalopram; oral
3.2
14.2
87
341
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.7
14.0
41
81
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
13.5
134
711
SPAT1301
SPAT
No procedures
2.7
13.4
115
559
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.8
13.3
60
185
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.4
13.3
29
38
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
20.2
13.1
19
10
N05AF03
ATC
chlorprothixene; systemic
10.8
12.7
24
24
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.0
12.6
21
16
R46.7
ICD-10 Finland
Verbosity and circumstantial detail obscuring reason for contact
+∞
12.6
12
*
N06AX21
ATC
duloxetine; oral
4.3
12.6
49
132
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
4.3
12.6
49
132
SPAT1263
SPAT
Sampling
2.5
12.5
151
879
S06.0
ICD-10 Finland
Concussion
4.0
12.4
53
155
N05AX12
ATC
aripiprazole; systemic
6.8
12.4
31
50
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
5.4
12.1
37
77
N06AB04
ATC
citalopram; systemic
3.0
12.0
77
307
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.7
11.8
99
467
183
Kela drug reimbursment
Lamotrigin and topiramate
24.1
11.7
16
7
R40.2
ICD-10 Finland
Coma, unspecified
+∞
11.5
11
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
9.5
11.5
23
26
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.7
11.5
33
64
R53
ICD-10 Finland
Malaise and fatigue
3.0
11.4
74
297
SPAT1240
SPAT
Therapeutic discussion
3.7
11.3
52
162
N05BA01
ATC
diazepam; systemic, rectal
3.6
11.3
53
168
N03AX12
ATC
gabapentin; oral
3.4
11.2
58
199
XA800
NOMESCO Finland
Neuropsychological investigation
7.4
11.1
26
38
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.2
11.0
34
72
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
10.2
61
231
C07AB07
ATC
bisoprolol; oral
2.3
10.2
125
711
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.8
10.0
17
14
WZC30
NOMESCO Finland
Teaching
3.5
9.9
48
156
N05BA06
ATC
lorazepam; systemic, sublingual
6.1
9.8
26
46
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
4.4
9.6
35
88
N05CD07
ATC
temazepam; oral
3.8
9.6
42
125
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.3
9.6
29
60
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.8
9.6
65
267
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.7
9.5
42
126
R07.4
ICD-10 Finland
Chest pain, unspecified
2.6
9.5
82
387
ZYC01
NOMESCO Finland
Remote contact by phone
5.6
9.5
27
52
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
9.5
49
167
R46.5
ICD-10 Finland
Suspiciousness and marked evasiveness
+∞
9.4
9
*
N03AX11
ATC
topiramate; oral
8.2
9.3
20
26
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
9.2
34
87
R51.80
ICD-10 Finland
Headache
2.9
9.2
60
240
N03AX16
ATC
pregabalin; oral
2.6
9.2
76
350
N06AB06
ATC
sertraline; oral
3.3
9.2
47
159
SPAT1260
SPAT
Consultation of another employee
2.7
9.2
66
281
P29
ICPC
Psychological sympt/compl other
4.2
9.1
34
88
F05.9
ICD-10 Finland
Delirium, unspecified
24.9
9.0
12
5
F99
ICD-10 Finland
Mental disorder, not otherwise specified
9.1
8.9
18
21
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
8.9
66
283
N04AA02
ATC
biperiden; systemic
9.9
8.9
17
18
R11
ICD-10 Finland
Nausea and vomiting
3.9
8.9
36
101
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.1
8.8
27
57
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.2
8.8
127
765
ZXE00
NOMESCO Finland
One hour or less
2.1
8.7
132
813
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.8
8.7
21
33
Z2445
NOMESCO Finland
Psychologist
4.9
8.6
27
59
N05BA09
ATC
clobazam; oral
28.5
8.5
11
*
SPAT1254
SPAT
Administration of medicine
2.7
8.4
59
247
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
+∞
8.4
8
*
N05AA02
ATC
levomepromazine; systemic
5.7
8.3
23
43
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.4
8.3
40
129
Z00.0
ICD-10 Finland
General medical examination
2.5
8.3
70
322
ZY000
NOMESCO Finland
Hospital inpatient
15.0
8.3
13
9
R06.0
ICD-10 Finland
Dyspnoea
2.4
8.3
75
361
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
34.4
8.1
10
*
N06AA09
ATC
amitriptyline; systemic
4.0
8.1
32
88
G43.9
ICD-10 Finland
Migraine, unspecified
4.4
8.0
28
68
TAB00
NOMESCO Finland
Lumbar puncture
5.7
8.0
22
41
N05BE01
ATC
buspirone; oral
8.1
8.0
17
22
XX3DW
NOMESCO Finland
Time consuming IT work
3.5
7.9
37
117
SPAT1243
SPAT
Psychiatric/psychological examination
5.9
7.8
21
38
N03AX18
ATC
lacosamide; systemic
46.2
7.8
9
*
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
7.7
65
301
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
7.7
59
256
IGV01
NOMESCO Finland
Psychiatric network contact
19.0
7.7
11
6
R41.3
ICD-10 Finland
Other amnesia
19.0
7.7
11
6
G47.3
ICD-10 Finland
Sleep apnoea
2.5
7.7
65
302
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
9.2
7.6
15
17
Z3231
NOMESCO Finland
Registered nurse
2.2
7.5
89
484
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.6
7.5
33
100
N03AF01
ATC
carbamazepine; oral, rectal
5.2
7.5
22
45
N17
ICPC
Vertigo/dizziness
3.6
7.4
33
101
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
7.4
108
645
N05AH02
ATC
clozapine; systemic
9.7
7.4
14
15
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
7.6
7.3
16
22
R1250
NOMESCO Finland
Evaluation of functional capability
7.6
7.3
16
22
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.2
7.3
37
125
R5140
NOMESCO Finland
Monitoring the use of the aid
3.2
7.3
38
131
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
7.3
113
689
N06AX26
ATC
vortioxetine; oral
4.4
7.2
25
61
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
20.6
7.2
10
5
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
5.2
7.1
21
43
SPAT1131
SPAT
Colonoscopy
7.3
7.1
16
23
Z2446
NOMESCO Finland
Social worker
3.5
7.1
32
99
K59.1
ICD-10 Finland
Functional diarrhoea
4.9
7.1
22
48
F43.1
ICD-10 Finland
Post-traumatic stress disorder
6.6
7.0
17
27
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.2
7.0
25
63
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
6.9
89
498
SPAT1307
SPAT
Psychosocial counselling and guidance
3.2
6.9
35
118
R25.2
ICD-10 Finland
Cramp and spasm
8.6
6.9
14
17
K59.0
ICD-10 Finland
Constipation
4.5
6.9
23
54
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.2
6.9
25
64
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
6.9
67
333
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
5.2
6.8
20
41
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
41.0
6.8
8
*
R06.4
ICD-10 Finland
Hyperventilation
8.1
6.7
14
18
M54.5
ICD-10 Finland
Low back pain
2.0
6.7
100
597
A02BC02
ATC
pantoprazole; systemic
1.9
6.6
172
1256
SPAT1130
SPAT
Esophagoscopy, gastroscopy and duodenoscopy
5.9
6.6
17
30
N06AB03
ATC
fluoxetine; oral
2.8
6.6
44
176
M54.4
ICD-10 Finland
Lumbago with sciatica
2.5
6.5
53
239
Z3229
NOMESCO Finland
Other healthcare associate professional
3.3
6.5
32
106
R52.1
ICD-10 Finland
Chronic intractable pain
14.7
6.4
10
7
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
14.7
6.4
10
7
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
14.7
6.4
10
7
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.4
6.4
57
269
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
11.4
6.3
11
10
N06AX12
ATC
bupropion; oral
3.6
6.3
27
80
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.3
78
428
L28
ICPC
Limited function/disability (L)
2.6
6.3
47
203
R46
ICD-10 Finland
Symptoms and signs involving appearance and behaviour
+∞
6.3
6
*
FPH96
NOMESCO Finland
Other removal of cardiac pacemaker or cardioverter-defibrillator
27.3
6.3
8
*
F41.09
ICD-10 Finland
UNS Panic Syndrome
5.1
6.2
18
37
F32.1
ICD-10 Finland
Moderate depressive episode
3.9
6.2
24
66
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.1
64
327
F10.20
ICD-10 Finland
Alcohol dependence currently independent
8.9
6.1
12
14
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.6
6.1
45
192
Mortality – FinRegistry
↥This endpoint is excluded from FinRegistry analyses (omitted endpoint).
Relationships between endpoints
↥Index endpoint: R18_SYMPTOMS_SIGNS_INVOLVI_APPEA_BEHVI – Symptoms and signs involving appearance and behaviour
GWS hits: -
This endpoint is excluded from FinRegistry analyses (omitted endpoint).