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Symptoms and signs involving appearance and behaviour

R18_SYMPTOMS_SIGNS_INVOLVI_APPEA_BEHVI

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 R46
  • Cause of death: ICD-10 R46

2 out of 7 registries used, show all original rules.

319

4. Check minimum number of events

None

319

5. Include endpoints

None

319

6. Filter based on genotype QC (FinnGen only)

319

Control definitions (FinnGen only)

Control exclude
R18_SYMPTOMS_SIGNS_INVOLVI_COGNITION_PERCEP_EMOTIONAL_STATE_BEHVI

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
R4[0-6]
Name in latin
Symptomata et signa ad habitum corporis et modum se gerendi pertinentia

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 319 206 113
Unadjusted period prevalence (%) 0.06 0.07 0.05
Median age at first event (years) 49.38 44.88 57.58

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
291
Matched controls
2908
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R46.8
ICD-10 Finland
Other symptoms and signs involving appearance and behaviour
+∞
226.8
187
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
16.8
55.4
93
79
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
52.8
47.4
56
13
R56.8
ICD-10 Finland
Other and unspecified convulsions
15.8
40.9
69
56
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
16.0
31.5
52
39
AA1AD
NOMESCO Finland
CT of head and brain
5.5
29.8
103
263
R55
ICD-10 Finland
Syncope and collapse
8.0
27.3
66
103
R46.6
ICD-10 Finland
Undue concern and preoccupation with stressful events
+∞
26.5
25
*
N05AX08
ATC
risperidone; systemic
8.4
24.4
56
80
R42
ICD-10 Finland
Dizziness and giddiness
7.2
24.3
63
108
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
21.9
24.1
35
18
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.2
23.7
55
80
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
7.8
22.9
55
84
N05AH04
ATC
quetiapine; oral
4.7
22.5
87
241
G40.9
ICD-10 Finland
Epilepsy, unspecified
14.4
22.4
38
30
N03AG01
ATC
valproic acid; systemic, rectal
9.0
21.6
47
61
R46.2
ICD-10 Finland
Strange and inexplicable behaviour
+∞
21.1
20
*
R41.0
ICD-10 Finland
Disorientation, unspecified
225.4
20.9
21
*
N03AX09
ATC
lamotrigine; oral
10.0
20.2
41
47
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
31.5
20.0
26
9
N05BA04
ATC
oxazepam; oral
3.7
19.4
102
369
N06AX16
ATC
venlafaxine; oral
4.6
19.0
73
198
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.7
18.7
70
184
N03AX14
ATC
levetiracetam; systemic
19.7
18.2
27
15
N05AH03
ATC
olanzapine; systemic
7.3
17.9
44
69
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
5.1
17.4
59
139
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.6
16.3
60
154
N06AX11
ATC
mirtazapine; oral
3.1
16.2
118
529
SPAT1249
SPAT
Treatment-related counselling outside office
2.9
16.1
151
796
N03AE01
ATC
clonazepam; systemic
7.1
15.4
38
60
N03AF02
ATC
oxcarbazepine; oral
10.3
15.4
30
32
F29
ICD-10 Finland
Unspecified nonorganic psychosis
9.0
14.7
31
38
R46.4
ICD-10 Finland
Slowness and poor responsiveness
+∞
14.7
14
*
R46.0
ICD-10 Finland
Very low level of personal hygiene
+∞
14.7
14
*
N06AB10
ATC
escitalopram; oral
3.2
14.2
87
341
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
5.7
14.0
41
81
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
13.5
134
711
SPAT1301
SPAT
No procedures
2.7
13.4
115
559
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.8
13.3
60
185
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
8.4
13.3
29
38
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
20.2
13.1
19
10
N05AF03
ATC
chlorprothixene; systemic
10.8
12.7
24
24
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.0
12.6
21
16
R46.7
ICD-10 Finland
Verbosity and circumstantial detail obscuring reason for contact
+∞
12.6
12
*
N06AX21
ATC
duloxetine; oral
4.3
12.6
49
132
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
4.3
12.6
49
132
SPAT1263
SPAT
Sampling
2.5
12.5
151
879
S06.0
ICD-10 Finland
Concussion
4.0
12.4
53
155
N05AX12
ATC
aripiprazole; systemic
6.8
12.4
31
50
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
5.4
12.1
37
77
N06AB04
ATC
citalopram; systemic
3.0
12.0
77
307
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.7
11.8
99
467
183
Kela drug reimbursment
Lamotrigin and topiramate
24.1
11.7
16
7
R40.2
ICD-10 Finland
Coma, unspecified
+∞
11.5
11
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
9.5
11.5
23
26
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
5.7
11.5
33
64
R53
ICD-10 Finland
Malaise and fatigue
3.0
11.4
74
297
SPAT1240
SPAT
Therapeutic discussion
3.7
11.3
52
162
N05BA01
ATC
diazepam; systemic, rectal
3.6
11.3
53
168
N03AX12
ATC
gabapentin; oral
3.4
11.2
58
199
XA800
NOMESCO Finland
Neuropsychological investigation
7.4
11.1
26
38
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.2
11.0
34
72
Z01.0
ICD-10 Finland
Examination of eyes and vision
3.1
10.2
61
231
C07AB07
ATC
bisoprolol; oral
2.3
10.2
125
711
F20.9
ICD-10 Finland
Schizophrenia, unspecified
12.8
10.0
17
14
WZC30
NOMESCO Finland
Teaching
3.5
9.9
48
156
N05BA06
ATC
lorazepam; systemic, sublingual
6.1
9.8
26
46
N05CD07
ATC
temazepam; oral
3.8
9.6
42
125
T36
ICD-10 Finland
Poisoning by systemic antibiotics
5.3
9.6
29
60
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.8
9.6
65
267
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.7
9.5
42
126
R07.4
ICD-10 Finland
Chest pain, unspecified
2.6
9.5
82
387
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
9.5
49
167
R46.5
ICD-10 Finland
Suspiciousness and marked evasiveness
+∞
9.4
9
*
N03AX11
ATC
topiramate; oral
8.2
9.3
20
26
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.3
9.2
34
87
R51.80
ICD-10 Finland
Headache
2.9
9.2
60
240
N03AX16
ATC
pregabalin; oral
2.6
9.2
76
350
N06AB06
ATC
sertraline; oral
3.3
9.2
47
159
SPAT1260
SPAT
Consultation of another employee
2.7
9.2
66
281
P29
ICPC
Psychological sympt/compl other
4.2
9.1
34
88
F05.9
ICD-10 Finland
Delirium, unspecified
24.9
9.0
12
5
F99
ICD-10 Finland
Mental disorder, not otherwise specified
9.1
8.9
18
21
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.7
8.9
66
283
N04AA02
ATC
biperiden; systemic
9.9
8.9
17
18
R11
ICD-10 Finland
Nausea and vomiting
3.9
8.9
36
101
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
5.1
8.8
27
57
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.2
8.8
127
765
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.8
8.7
21
33
N05BA09
ATC
clobazam; oral
28.5
8.5
11
*
SPAT1254
SPAT
Administration of medicine
2.7
8.4
59
247
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
+∞
8.4
8
*
N05AA02
ATC
levomepromazine; systemic
5.7
8.3
23
43
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.4
8.3
40
129
Z00.0
ICD-10 Finland
General medical examination
2.5
8.3
70
322
R06.0
ICD-10 Finland
Dyspnoea
2.4
8.3
75
361
F44.9
ICD-10 Finland
Dissociative [conversion] disorder, unspecified
34.4
8.1
10
*
N06AA09
ATC
amitriptyline; systemic
4.0
8.1
32
88
G43.9
ICD-10 Finland
Migraine, unspecified
4.4
8.0
28
68
TAB00
NOMESCO Finland
Lumbar puncture
5.7
8.0
22
41
N05BE01
ATC
buspirone; oral
8.1
8.0
17
22
XX3DW
NOMESCO Finland
Time consuming IT work
3.5
7.9
37
117
SPAT1243
SPAT
Psychiatric/psychological examination
5.9
7.8
21
38
N03AX18
ATC
lacosamide; systemic
46.2
7.8
9
*
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
7.7
65
301
J45.9
ICD-10 Finland
Asthma, unspecified
2.6
7.7
59
256
R41.3
ICD-10 Finland
Other amnesia
19.0
7.7
11
6
IGV01
NOMESCO Finland
Psychiatric network contact
19.0
7.7
11
6
G47.3
ICD-10 Finland
Sleep apnoea
2.5
7.7
65
302
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
9.2
7.6
15
17
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
3.6
7.5
33
100
N03AF01
ATC
carbamazepine; oral, rectal
5.2
7.5
22
45
N17
ICPC
Vertigo/dizziness
3.6
7.4
33
101
N05AH02
ATC
clozapine; systemic
9.7
7.4
14
15
R1250
NOMESCO Finland
Evaluation of functional capability
7.6
7.3
16
22
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
7.6
7.3
16
22
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.2
7.3
37
125
R5140
NOMESCO Finland
Monitoring the use of the aid
3.2
7.3
38
131
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
7.3
113
689
N06AX26
ATC
vortioxetine; oral
4.4
7.2
25
61
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
20.6
7.2
10
5
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
5.2
7.1
21
43
SPAT1131
SPAT
Colonoscopy
7.3
7.1
16
23
K59.1
ICD-10 Finland
Functional diarrhoea
4.9
7.1
22
48
F43.1
ICD-10 Finland
Post-traumatic stress disorder
6.6
7.0
17
27
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
4.2
7.0
25
63
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.1
6.9
89
498
SPAT1307
SPAT
Psychosocial counselling and guidance
3.2
6.9
35
118
R25.2
ICD-10 Finland
Cramp and spasm
8.6
6.9
14
17
K59.0
ICD-10 Finland
Constipation
4.5
6.9
23
54
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
4.2
6.9
25
64
Z01.8
ICD-10 Finland
Other specified special examinations
2.3
6.9
67
333
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
5.2
6.8
20
41
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
41.0
6.8
8
*
R06.4
ICD-10 Finland
Hyperventilation
8.1
6.7
14
18
M54.5
ICD-10 Finland
Low back pain
2.0
6.7
100
597
A02BC02
ATC
pantoprazole; systemic
1.9
6.6
172
1256
SPAT1130
SPAT
Esophagoscopy, gastroscopy and duodenoscopy
5.9
6.6
17
30
N06AB03
ATC
fluoxetine; oral
2.8
6.6
44
176
M54.4
ICD-10 Finland
Lumbago with sciatica
2.5
6.5
53
239
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
14.7
6.4
10
7
AA3AI
NOMESCO Finland
Cone beam CT of facial bones
14.7
6.4
10
7
R52.1
ICD-10 Finland
Chronic intractable pain
14.7
6.4
10
7
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.4
6.4
57
269
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
11.4
6.3
11
10
N06AX12
ATC
bupropion; oral
3.6
6.3
27
80
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
6.3
78
428
L28
ICPC
Limited function/disability (L)
2.6
6.3
47
203
R46
ICD-10 Finland
Symptoms and signs involving appearance and behaviour
+∞
6.3
6
*
FPH96
NOMESCO Finland
Other removal of cardiac pacemaker or cardioverter-defibrillator
27.3
6.3
8
*
F41.09
ICD-10 Finland
UNS Panic Syndrome
5.1
6.2
18
37
F32.1
ICD-10 Finland
Moderate depressive episode
3.9
6.2
24
66
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.1
64
327
F10.20
ICD-10 Finland
Alcohol dependence currently independent
8.9
6.1
12
14
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.6
6.1
45
192

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
95
173
7.40
53.51
4.5
3.3
1.2
1.2
mmol/l
1.03
81
151
48
44
12.66
46.18
5.6
2.8
2.5
2.8
mmol/l
0.26
32
33
94
218
5.70
40.45
4.7
3.7
—
—
—
0
0
130
433
4.38
35.30
2.0
1.7
466.0
432.3
pmol/l
0.74
107
370
183
833
3.81
30.74
10.9
7.5
1.1
1.2
inr
0.55
127
279
217
1112
3.98
30.30
16.1
8.7
0.0
0.0
e9/l
0.50
195
890
152
619
3.78
30.11
3.8
2.1
229.0
301.9
u/l
0.25
146
581
72
181
4.85
27.47
3.8
4.8
0.1
0.0
%
0.29
14
47
36
45
8.89
27.43
4.3
2.0
—
—
—
0
0
32
37
9.50
25.85
4.3
1.9
16.9
15.7
%
0.72
18
16
174
831
3.41
25.85
5.4
3.4
19.6
39.2
ng/l
2.03
116
494
73
197
4.51
25.37
3.7
4.6
0.1
0.2
%
0.14
15
58
118
448
3.59
25.27
3.4
2.5
485.2
560.9
mosm/kgh2o
3.08
107
379
33
41
8.86
25.22
2.7
3.3
4.3
3.9
e9/l
0.30
33
41
71
189
4.55
25.09
3.3
4.5
0.5
0.5
%
0.00
13
39
33
42
8.65
24.73
2.8
3.9
56.2
56.0
%
0.03
33
42
74
206
4.38
24.66
3.7
4.5
0.3
0.8
%
1.82
15
65
198
1072
3.23
22.93
5.5
6.0
1.2
1.2
mmol/l
0.46
128
906
95
334
3.63
22.59
3.3
3.3
0.8
0.8
mmol/l
0.03
88
314
144
655
3.18
22.48
5.3
3.8
0.0
0.0
estimate
0.00
94
246
142
650
3.13
21.79
4.0
3.7
7.4
7.4
ph
0.03
71
119
137
615
3.15
21.74
5.0
4.7
—
—
—
0
0
155
751
3.07
21.43
4.3
3.1
—
—
—
0
0
24
24
10.73
21.41
4.0
1.5
90.4
88.7
%
0.61
24
24
227
1371
3.27
21.00
5.9
4.1
6.2
6.5
mmol/l
1.45
211
1246
71
217
3.92
20.60
2.1
1.8
382.0
368.9
nmol/l
0.18
66
199
112
472
3.12
19.48
3.8
2.4
8.2
7.2
e6/l
0.20
102
417
147
727
2.90
19.06
2.1
3.1
2.3
2.4
mmol/l
0.48
136
649
26
40
6.99
16.46
1.8
1.4
—
—
—
0
0
170
965
2.63
16.07
5.3
5.3
1.2
1.2
mmol/l
1.10
152
877
88
357
3.02
15.99
2.0
1.7
1631.1
1191.7
nmol/l
2.40
67
269
126
619
2.71
15.97
4.4
3.4
—
—
—
0
0
135
687
2.67
15.94
4.3
2.7
—
—
—
0
0
137
720
2.58
14.93
4.0
2.8
25.2
54.3
e6/l
1.05
118
536
199
1251
2.57
14.74
4.9
3.4
0.0
0.0
estimate
0.00
96
248
199
1254
2.56
14.61
5.8
4.8
0.0
0.0
estimate
0.00
96
248
27
49
5.93
14.57
1.7
1.2
5.0
8.4
e6/l
0.21
21
38
124
638
2.54
13.95
3.8
2.7
—
—
—
0
0
125
650
2.52
13.70
3.9
2.8
0.3
0.3
e6/l
0.22
105
470
198
1269
2.48
13.65
4.9
3.5
0.0
0.0
estimate
0.50
95
242
237
1655
2.68
13.52
4.8
3.4
—
—
—
0
0
156
917
2.37
12.82
3.7
4.3
34.9
36.3
g/l
2.29
145
863
23
41
5.97
12.61
2.3
2.1
—
—
—
0
0
136
770
2.34
12.00
6.5
5.0
—
—
—
0
0
126
695
2.34
11.76
3.4
2.3
53.8
56.4
u/l
0.30
116
642
104
537
2.39
11.20
5.3
4.1
—
—
—
0
0
248
1850
2.53
10.98
8.5
6.7
71.9
76.3
u/l
1.44
231
1722
25
57
4.67
10.46
2.4
2.4
8.2
8.2
kpa
0.10
25
52
143
866
2.18
10.35
4.7
3.3
32.9
66.8
e6/l
1.08
120
577
12
13
9.55
9.93
1.3
1.1
—
—
—
0
0
105
572
2.25
9.79
2.6
1.9
3.2
2.9
mg/l
0.94
94
481
94
490
2.30
9.73
1.6
1.4
20.0
21.2
nmol/l
0.28
80
416
253
1953
2.43
9.57
5.6
4.0
14.8
14.6
pmol/l
0.85
232
1782
174
1163
2.09
9.48
3.3
2.6
100.9
100.2
ug/l
0.02
159
1090
14
21
6.93
8.97
10.3
15.9
689.7
920.4
nmol/l
0.83
14
21
14
21
6.93
8.97
15.9
21.0
1270.1
1545.0
nmol/l
0.58
14
21
171
1154
2.04
8.87
8.2
5.5
8.3
8.4
%
0.28
162
1091
170
1148
2.03
8.77
8.0
5.3
2.6
2.8
%
0.41
162
1078
177
1225
2.00
8.39
7.7
5.3
0.6
0.6
e9/l
1.32
159
1071
299
2559
3.69
8.29
23.1
12.7
139.1
139.7
mmol/l
2.93
292
2482
164
1110
1.98
8.24
8.1
5.3
0.6
0.7
%
0.47
156
1038
177
1230
1.99
8.24
7.8
5.3
0.0
0.0
e9/l
0.45
160
1076
299
2565
3.64
8.13
22.9
12.8
3.9
3.9
mmol/l
0.05
291
2481
174
1208
1.97
8.06
5.2
5.8
8.6
10.5
umol/l
5.33
163
1135
181
1278
1.96
7.93
8.1
5.6
0.2
0.2
e9/l
0.11
165
1137
236
1846
2.07
7.49
5.5
3.6
10.9
10.6
mm/h
0.15
222
1690
215
1629
1.98
7.45
7.2
3.9
12866.7
268.4
e6/l
—
6
25
171
1201
1.91
7.44
8.0
5.3
28.7
29.1
%
0.21
162
1133
34
123
2.97
7.33
2.6
2.9
7.4
7.4
ph
0.16
14
16
34
124
2.95
7.22
2.6
2.8
5.1
5.1
kpa
0.16
34
112
178
1276
1.89
7.18
7.8
5.3
2.0
2.0
e9/l
0.19
163
1144
93
546
1.99
6.78
2.1
1.7
0.9
1.1
mg/l
0.39
67
407
269
2244
2.27
6.74
23.2
14.2
13.7
13.6
%
0.47
263
2206
193
1444
1.85
6.57
11.2
8.6
4.1
4.0
e9/l
0.14
174
1259
141
967
1.82
6.30
3.4
2.7
—
—
—
0
0
11
19
5.96
6.15
1.2
1.5
—
—
nmol/l
—
0
0
11
19
5.96
6.15
1.2
1.4
—
—
—
0
0
220
1735
1.86
6.10
5.7
3.8
—
—
—
0
0
141
979
1.79
5.96
4.1
3.2
—
—
—
0
0
38
163
2.51
5.93
3.7
2.4
6476.4
3642.9
u/l
0.34
11
63
42
189
2.41
5.92
3.9
2.7
2.9
1.7
mmol/l
1.07
37
143
275
2350
2.23
5.91
6.3
4.5
1.8
1.9
mu/l
0.40
252
2162
163
1183
1.77
5.90
7.8
5.1
57.2
56.4
%
0.38
153
1118
9
7
13.18
5.61
2.3
1.9
136.8
144.7
nmol/l
—
9
7
22
73
3.16
5.49
5.9
4.4
—
—
—
0
0
14
34
4.26
5.41
1.4
2.1
—
—
—
0
0
67
377
1.98
5.41
2.4
2.7
2.4
2.4
mmol/l
0.22
60
331
28
110
2.69
5.20
2.8
3.0
—
—
—
0
0
55
300
2.01
4.82
1.4
1.2
—
—
—
0
0
289
2584
2.26
4.51
23.2
11.5
15.2
21.9
mg/l
4.00
262
2001
34
159
2.27
4.40
1.3
1.2
—
—
—
0
0
38
192
2.11
4.08
2.1
2.2
0.2
0.2
g/l
1.15
33
183
48
268
1.93
3.93
1.9
1.6
—
—
—
0
0
32
154
2.20
3.88
3.1
1.9
—
—
—
0
0
27
122
2.33
3.79
3.3
2.1
—
—
—
0
0
9
16
5.75
3.68
1.2
1.0
—
—
—
0
0
30
144
2.20
3.67
3.2
2.0
—
—
—
0
0
31
153
2.14
3.54
3.1
1.7
—
—
—
0
0
19
75
2.63
3.53
4.1
2.6
—
—
—
0
0
271
2418
1.80
3.52
5.1
3.9
5.8
5.8
mmol/l
0.33
243
2223
31
155
2.11
3.43
3.1
1.9
—
—
—
0
0
31
156
2.09
3.38
3.1
1.9
—
—
—
0
0
115
853
1.54
3.30
2.0
1.8
90.8
95.8
pmol/l
0.52
64
436
11
33
3.42
3.22
2.4
12.1
6.2
6.3
mmol/l
0.05
11
28
150
1183
1.51
3.21
4.7
4.1
—
—
—
0
0
7
11
6.48
3.20
2.4
2.8
—
—
—
0
0
16
61
2.71
3.18
1.4
1.5
355.7
266.4
ug/g
—
6
36
5
180
0.27
3.07
1.0
1.4
—
—
—
0
0
6
8
7.62
3.06
1.0
4.1
63.5
111.0
nmol/l
—
6
8
66
438
1.64
3.01
1.4
1.3
54.8
25.8
iu/ml
0.46
19
131
12
40
3.08
3.00
1.8
1.2
27.6
5.9
iu/ml
—
7
7
16
65
2.54
2.83
1.4
1.2
—
—
—
0
0
10
31
3.30
2.79
3.6
2.3
104.0
106.0
mmol/l
—
10
31
10
31
3.30
2.79
3.6
2.3
3.8
4.1
mmol/l
—
10
31
253
2260
1.58
2.76
6.2
5.1
39.6
38.9
mmol/mol
0.48
230
2105
5
6
8.44
2.76
2.6
1.0
—
—
—
0
0
15
329
0.43
2.73
1.3
1.3
—
—
—
0
0
293
2722
1.94
2.73
22.6
10.9
—
—
—
0
0
38
225
1.78
2.61
12.2
20.0
1.1
1.3
inr
—
10
32
44
272
1.72
2.61
1.5
1.3
—
—
—
0
0
54
354
1.63
2.58
2.7
2.1
334.4
95.2
ug/g
0.89
38
273
87
642
1.49
2.47
1.4
1.2
2.2
1.5
u/ml
0.22
33
180
92
687
1.48
2.46
3.4
3.1
7.7
8.0
mmol/l
0.26
72
589
5
8
6.33
2.38
1.2
1.3
—
—
—
0
0
293
2742
1.84
2.36
12.9
8.8
24.8
25.3
u/l
0.23
283
2647
9
29
3.16
2.24
1.0
1.1
—
—
—
0
0
20
101
2.05
2.21
3.8
2.0
0.7
0.7
%
0.27
20
101
23
124
1.92
2.13
3.0
2.6
0.1
0.1
e6/l
0.16
23
119
8
25
3.25
2.11
1.9
1.3
—
—
—
0
0
19
96
2.04
2.10
1.3
1.3
—
1.6
—
0
6
9
31
2.96
2.09
3.9
2.3
—
—
—
0
0
5
10
5.06
2.08
1.0
3.8
1.5
3.1
ug/l
—
5
10
44
291
1.59
2.04
2.2
2.1
22.1
24.3
%
0.58
39
254
260
2385
1.49
2.03
3.9
3.5
1.3
1.3
mmol/l
0.09
235
2214
7
21
3.38
1.97
1.4
1.4
—
—
—
0
0
27
159
1.76
1.92
2.6
2.4
2.7
6.8
ug/l
2.83
21
137
41
271
1.59
1.91
1.8
2.3
4.6
8.8
umol/l
2.05
33
236
8
28
2.90
1.87
1.1
6.3
—
—
—
0
0
84
649
1.40
1.83
1.6
1.6
1.6
1.4
mmol/l
0.97
53
554
48
337
1.50
1.72
1.6
1.4
326.7
486.4
titre
—
6
69
25
149
1.74
1.72
1.7
2.9
79.0
72.2
e9/l
0.31
19
114
5
13
3.89
1.72
1.0
1.6
9.8
15.4
ug/l
—
5
13
23
135
1.76
1.67
4.6
4.2
—
—
—
0
0
10
43
2.37
1.62
1.1
4.7
41.6
80.1
mg/l
—
5
37
10
43
2.37
1.62
1.1
4.7
29.8
30.9
mg/l
—
5
37
6
20
3.04
1.59
2.8
2.0
—
—
—
0
0
8
33
2.46
1.55
1.6
1.2
—
—
—
0
0
79
622
1.36
1.52
4.8
4.0
3.6
10.6
mg/mmol
2.22
45
399
0
45
0.00
1.51
0.0
3.0
—
42.2
—
0
45
58
437
1.40
1.46
1.5
1.3
2.2
9.2
u/ml
2.14
36
172
18
103
1.79
1.44
1.6
2.4
—
—
—
0
0
5
17
2.97
1.36
1.2
1.2
—
—
—
0
0
45
328
1.43
1.36
2.6
2.0
—
—
—
0
0
74
588
1.34
1.34
3.1
3.2
19.6
173.8
mg/l
0.81
43
382
33
227
1.51
1.33
4.5
6.5
1.9
1.0
mmol/l
1.02
27
183
264
2482
1.37
1.31
4.4
3.9
1.4
1.5
mmol/l
0.71
236
2308
265
2493
1.37
1.31
4.5
3.9
4.6
4.7
mmol/l
1.56
237
2329
33
228
1.50
1.30
1.3
1.3
122.2
148.6
iu/ml
0.12
15
91
21
132
1.63
1.24
1.6
1.3
29.8
21.3
iu/l
0.32
14
112
28
189
1.53
1.24
1.3
1.4
—
—
—
0
0
5
19
2.66
1.22
1.4
5.1
—
—
—
0
0
24
158
1.56
1.18
1.3
1.2
181.6
301.4
u/ml
0.33
24
139
23
152
1.55
1.12
1.2
1.2
—
—
—
0
0
9
165
0.53
1.11
1.8
1.6
—
—
—
0
0
51
396
1.34
1.08
5.3
3.1
74.6
196.8
ng/l
1.04
32
282
267
2534
1.33
1.08
4.7
4.3
2.7
2.8
mmol/l
0.90
238
2356
25
354
0.68
1.04
1.7
1.5
—
—
—
0
0
9
47
1.94
1.03
1.1
1.2
—
—
—
0
0
27
190
1.46
1.01
4.9
7.3
121.5
120.7
g/l
0.09
27
183
302
2932
1.56
0.99
31.2
17.0
260.5
255.2
e9/l
0.68
296
2856
0
30
0.00
0.98
0.0
3.4
—
—
—
0
0
302
2934
1.55
0.96
31.2
17.0
4.5
4.5
e12/l
0.43
296
2847
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
25
176
1.46
0.94
5.1
5.9
—
—
—
0
0
302
2936
1.54
0.93
31.4
17.1
7.0
6.7
e9/l
2.00
296
2851
19
126
1.54
0.93
1.2
2.5
—
—
—
0
0
16
102
1.60
0.92
1.3
1.3
—
—
—
0
0
6
28
2.16
0.92
1.3
1.1
—
—
—
0
0
36
273
1.36
0.90
1.6
1.4
—
—
—
0
0
39
300
1.34
0.90
1.2
1.2
—
—
—
0
0
11
180
0.60
0.89
1.1
1.3
—
—
—
0
0
23
162
1.45
0.87
4.3
6.3
7.0
8.5
mmol/l
0.58
23
155
15
96
1.59
0.86
1.9
1.7
—
—
—
0
0
69
580
1.24
0.82
7.6
6.3
—
—
—
0
0
18
123
1.49
0.79
2.9
3.2
—
—
—
0
0
5
25
2.02
0.73
3.4
2.1
0.5
1.2
e9/l
—
5
10
20
143
1.43
0.72
3.6
3.6
100.8
75.7
ng/l
0.45
12
128
7
40
1.77
0.71
1.3
1.1
—
—
—
0
0
15
101
1.51
0.71
1.1
1.3
—
—
—
0
0
7
41
1.72
0.70
1.9
1.2
—
—
—
0
0
5
27
1.86
0.68
1.6
2.0
—
—
—
0
0
5
27
1.86
0.68
3.6
2.6
—
—
—
0
0
76
665
1.19
0.62
1.9
2.0
—
—
—
0
0
13
89
1.48
0.59
2.5
3.0
—
—
—
0
0
16
218
0.72
0.58
1.4
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
6
35
1.73
0.58
1.5
1.1
—
—
—
0
0
15
107
1.42
0.56
5.3
7.4
—
—
—
0
0
9
63
1.44
0.52
2.0
2.3
6.9
10.4
mg/l
—
9
58
89
802
1.15
0.51
1.8
1.6
—
—
—
0
0
37
309
1.22
0.49
1.6
1.9
—
—
—
0
0
12
85
1.43
0.47
1.1
1.7
—
—
—
0
0
10
68
1.49
0.47
3.8
3.7
—
—
—
0
0
10
69
1.46
0.45
2.9
2.8
—
—
—
0
0
18
140
1.30
0.43
1.1
1.1
—
—
—
0
0
26
213
1.24
0.42
3.2
4.7
3.4
9.5
ug/l
1.77
20
174
5
33
1.52
0.41
1.8
2.1
6292.5
2.7
u/ml
—
5
28
0
15
0.00
0.41
0.0
1.1
—
171.2
—
0
15
8
59
1.36
0.41
1.1
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
35.1
—
0
5
63
568
1.14
0.36
1.4
1.3
2.5
2.2
g/l
0.73
41
358
14
179
0.77
0.36
4.4
3.2
—
—
—
0
0
65
588
1.13
0.36
2.0
2.5
315.0
8139.6
umol/l
2.65
57
517
5
78
0.64
0.36
1.0
1.1
—
—
—
0
0
5
78
0.64
0.36
1.0
1.2
—
—
—
0
0
6
47
1.28
0.32
6.3
6.2
109.0
104.9
mmol/l
—
6
41
6
47
1.28
0.32
6.3
6.2
11.2
10.3
mmol/l
—
6
41
20
165
1.23
0.32
3.5
2.3
—
—
—
0
0
50
553
0.89
0.30
5.7
3.3
—
—
—
0
0
14
172
0.81
0.28
3.7
2.2
5.8
3.9
e9/l
—
9
146
9
75
1.21
0.25
2.8
3.3
24.0
24.7
mmol/l
—
9
70
81
759
1.09
0.24
2.5
2.3
—
—
—
0
0
62
575
1.10
0.23
4.0
4.5
15.8
2.0
ug/l
0.50
51
517
10
79
1.27
0.22
10.3
8.9
—
—
—
0
0
5
41
1.22
0.22
1.6
1.7
—
—
—
0
0
25
220
1.15
0.22
1.6
1.5
—
—
—
0
0
5
42
1.19
0.21
1.2
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
—
—
0
0
0
10
0.00
0.21
0.0
2.2
—
3.7
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
0.2
—
0
5
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
6
52
1.16
0.19
2.3
1.9
—
—
—
0
0
52
555
0.92
0.17
6.1
3.6
1.0
1.0
kg/l
—
10
74
240
2438
0.94
0.17
18.0
12.1
39.9
40.1
%
0.16
137
1895
9
80
1.13
0.15
1.6
2.4
—
—
—
0
0
101
976
1.05
0.13
2.1
2.0
—
—
—
0
0
38
406
0.93
0.13
1.7
1.7
—
—
—
0
0
16
179
0.89
0.12
3.8
4.4
—
—
—
0
0
39
368
1.07
0.11
2.1
1.5
—
—
—
0
0
5
45
1.11
0.10
2.2
1.8
—
—
—
0
0
57
549
1.05
0.08
1.8
1.7
—
—
—
0
0
23
242
0.95
0.05
1.6
1.4
—
—
—
0
0
12
114
1.05
0.00
1.2
1.1
—
—
—
0
0
11
105
1.05
0.00
2.3
1.2
—
—
—
0
0
33
326
1.01
0.00
2.8
2.7
0.4
0.8
ug/l
5.11
19
195
5
55
0.91
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
2.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
11.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
82.3
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
1.2
—
0
5
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
5.6
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: R18_SYMPTOMS_SIGNS_INVOLVI_APPEA_BEHVI – Symptoms and signs involving appearance and behaviour

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).