Malignant neoplasm of vulva, excluding all cancers (controls excluding all cancers)

C3_VULVA_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C51
  • Hospital discharge: ICD-9 184[1-4]
  • Hospital discharge: ICD-8 1841
  • Cause of death: ICD-10 C51
  • Cause of death: ICD-9 184[1-4]
  • Cause of death: ICD-8 1841
  • Cancer registry: Topography ICD-O-3 C51
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

466

4. Check minimum number of events

None

466

5. Include endpoints

None

466

6. Filter based on genotype QC (FinnGen only)

466

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of vulva, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 466 466 -
Unadjusted period prevalence (%) 0.16 0.16 -
Median age at first event (years) 65.99 65.99 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
275
Matched controls
2750
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
LFB00
NOMESCO Finland
Biopsy of vulva or perineum
116.9
166.8
173
39
ULA02
NOMESCO Finland
Kolposcopy
40.7
137.9
188
138
LFC00
NOMESCO Finland
Partial excision of vulva
2138.4
136.5
121
*
8070/3-C51.9
ICD-O-3
Squamous cell carcinoma, NOS, of vulva, NOS
+∞
122.3
108
*
C51.01
ICD-10 Finland
Squamous cell carcinoma of the labium majus
+∞
114.8
102
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
102.7
92
*
C51.11
ICD-10 Finland
Squamous cell carcinoma of the labium minus
+∞
80.2
73
*
C51.9
ICD-10 Finland
Malignant neoplasm: Vulva, unspecified
+∞
71.0
65
*
LFD10
NOMESCO Finland
Vulvectomy and excision of regional lymph nodes
+∞
68.7
63
*
B01AB10
ATC
tinzaparin; parenteral
26.6
64.2
91
50
128
Kela drug reimbursment
Cancers of female genital organs
+∞
58.5
54
*
LFB10
NOMESCO Finland
Excision of lesion of vulva or perineum
55.0
54.6
64
15
PJD55
NOMESCO Finland
Block dissection of inguinal lymph nodes
+∞
51.7
48
*
C51.81
ICD-10 Finland
Squamous cell carcinoma of the vulva
+∞
49.5
46
*
ZZR00
NOMESCO Finland
Flap of skin
112.9
44.4
47
5
XLD00
NOMESCO Finland
Sytologyspecimen from mouth of uterus
8.6
44.2
110
197
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
43.9
41
*
L90.0
ICD-10 Finland
Lichen sclerosus et atrophicus
16.7
42.9
71
56
C51.00
ICD-10 Finland
Malignant tumor of the labium majus without histology
+∞
39.5
37
*
H02AB02
ATC
dexamethasone; systemic
41.2
38.7
48
14
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
38.4
36
*
WF002
NOMESCO Finland
Radical radiotherapy
206.2
35.7
36
*
PJ5AQ
NOMESCO Finland
Sentinell lymphnode SPECT with low dose CT
+∞
35.2
33
*
JN4BD
NOMESCO Finland
Extensive body CT
14.5
35.0
61
53
JN2DG
NOMESCO Finland
Very extensive MRI examination of lower part of abdoment with high intensity magnet
56.5
33.5
39
8
D07.1
ICD-10 Finland
Carcinoma in situ: Vulva
+∞
33.0
31
*
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
4.9
32.6
149
534
LEB00
NOMESCO Finland
Biopsy of vagina
22.8
31.8
46
24
XX3DW
NOMESCO Finland
Time consuming IT work
11.2
29.6
58
64
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
23.8
28.8
41
20
D39.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other female genital organs
+∞
28.6
27
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
25.0
27.9
39
18
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
4.4
26.6
126
444
C51.04
ICD-10 Finland
Basal cell carcinoma of labium majus
+∞
26.5
25
*
N76.6
ICD-10 Finland
Ulceration of vulva
37.2
26.2
33
10
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
13.9
25.9
45
38
JN4AD
NOMESCO Finland
Body CT examination
14.3
25.6
44
36
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
25.4
24
*
8070/3-C51.0
ICD-O-3
Squamous cell carcinoma, NOS, of labium majus
+∞
25.4
24
*
8070/3-C51.1
ICD-O-3
Squamous cell carcinoma, NOS, of labium minus
+∞
25.4
24
*
D07AD01
ATC
clobetasol; topical
4.9
24.8
95
267
LX1AE
NOMESCO Finland
Gynecological ultrasound examination as part of clinical examination
6.3
24.7
72
147
LFD00
NOMESCO Finland
Vulvectomy
+∞
24.3
23
*
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
6.1
24.2
72
150
N90.8
ICD-10 Finland
Other specified noninflammatory disorders of vulva and perineum
71.4
23.3
26
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
71.4
23.3
26
*
LX1XE
NOMESCO Finland
Other gynecological ultrasound examination
10.8
22.9
45
49
A04AA01
ATC
ondansetron; systemic, rectal
15.2
21.7
36
27
JN2CG
NOMESCO Finland
Extensive MRI examination of lower part of abdoment with high intensity magnet
40.8
21.2
26
7
PJD45
NOMESCO Finland
Excision of inguinal lymph nodes
+∞
21.1
20
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.4
21.0
87
259
A04AA02
ATC
granisetron; systemic, transdermal
119.1
20.9
22
*
N90.2
ICD-10 Finland
Severe vulvar dysplasia, not elsewhere classified
119.1
20.9
22
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
226.4
20.9
21
*
C51.09
ICD-10 Finland
Malignant tumor of the labium majus, unspecified histology
+∞
20.0
19
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
20.0
19
*
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
20.6
19.1
28
15
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
19.0
18
*
8090/3-C51.9
ICD-O-3
Basal cell carcinoma, NOS, of vulva, NOS
+∞
19.0
18
*
YL1AD
NOMESCO Finland
CT examination of pelvis for dose design of radiotherapy
+∞
17.9
17
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
17.9
17
*
C77.4
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Inguinal and lower limb lymph nodes
+∞
17.9
17
*
130
Kela drug reimbursment
Malignant tumour
+∞
17.9
17
*
115
Kela drug reimbursment
Breast cancer
+∞
16.8
16
*
C51.1
ICD-10 Finland
Malignant neoplasm: Labium minus
+∞
16.8
16
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
180.5
16.7
17
*
WX306
NOMESCO Finland
Lumbar epidural anesthesy
7.4
16.4
40
62
WX402
NOMESCO Finland
General anaesthesia
4.5
16.2
63
172
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
15.8
15
*
8542/3-C51.9
ICD-O-3
Paget disease, extramammary of vulva, NOS
+∞
15.8
15
*
YJ2VG
NOMESCO Finland
MRI examination of pelvis with high intensity magnet for dose design of radiotherapy
+∞
15.8
15
*
B01AB05
ATC
enoxaparin; parenteral
3.0
15.7
125
597
N90.9
ICD-10 Finland
Noninflammatory disorder of vulva and perineum, unspecified
40.6
15.6
19
5
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
14.7
14
*
Z51.5
ICD-10 Finland
Palliative care
10.3
14.3
28
30
N02AA05
ATC
oxycodone; systemic
3.6
13.7
68
228
N90.0
ICD-10 Finland
Mild vulvar dysplasia
36.1
13.7
17
5
C51.21
ICD-10 Finland
Squamous cell carcinoma of the clitoris
+∞
13.7
13
*
8720/3-C51.9
ICD-O-3
Malignant melanoma, NOS, of vulva, NOS
+∞
13.7
13
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
13.7
13
*
ZX095
NOMESCO Finland
Combined chemoradiotherapy
147.0
13.6
14
*
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
147.0
13.6
14
*
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
10.1
13.3
26
28
QBB05
NOMESCO Finland
Revision of wound of skin of trunk
33.8
12.7
16
5
8090/3-C51.0
ICD-O-3
Basal cell carcinoma, NOS, of labium majus
+∞
12.6
12
*
C51.0
ICD-10 Finland
Malignant neoplasm: Labium majus
+∞
12.6
12
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
12.6
12
*
C51.19
ICD-10 Finland
Adenocarcinoma of the labium minus, unspecified histology
+∞
12.6
12
*
C51.89
ICD-10 Finland
Overall malignant tumor of the vulva, unspecified histology
+∞
12.6
12
*
A04AD12
ATC
aprepitant; systemic
+∞
12.6
12
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.3
12.4
38
80
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
48.9
12.0
14
*
LFE10
NOMESCO Finland
Plastic repair of vulva
67.9
11.7
13
*
N90.1
ICD-10 Finland
Moderate vulvar dysplasia
67.9
11.7
13
*
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
67.9
11.7
13
*
D28.0
ICD-10 Finland
Benign neoplasm: Vulva
67.9
11.7
13
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
11.5
11
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
11.5
11
*
Y83.8
ICD-10 Finland
Other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
9.5
11.5
23
26
HA1AA
NOMESCO Finland
X-ray mammography
6.0
11.0
30
55
LCA06
NOMESCO Finland
Biopsy of endometrium
3.4
10.9
57
197
LFB20
NOMESCO Finland
Destruction of lesion of vulva or perineum
29.4
10.8
14
5
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
10.5
10
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
10.5
10
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
10.5
10
*
HAC20
NOMESCO Finland
Total mastectomy
+∞
10.5
10
*
QB9S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in torso, unspecified
+∞
10.5
10
*
C51.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of vulva
+∞
10.5
10
*
C51.13
ICD-10 Finland
Melanoma and labium minus
+∞
10.5
10
*
L02BG04
ATC
letrozole; oral
34.0
10.4
13
*
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
6.9
10.3
25
39
X77
ICPC
Malignant neopl genital female other
57.1
9.7
11
*
SPAT1144
SPAT
Treatment of reopened or infected surgical wound
4.0
9.7
39
109
WZC30
NOMESCO Finland
Teaching
3.8
9.6
42
126
LFW96
NOMESCO Finland
Other operation on vulva or perineum
103.4
9.5
10
*
WW500
NOMESCO Finland
Blood transfusion
9.2
9.5
19
22
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
9.4
9
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
+∞
9.4
9
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
9.1
39
115
WX320
NOMESCO Finland
Spinalanesthesy
2.4
8.8
88
449
HAB40
NOMESCO Finland
Wedge excision of mammary gland
14.7
8.8
14
10
LWA00
NOMESCO Finland
Repair of wound dehiscence in gynaecological surgery
51.7
8.7
10
*
L03.3
ICD-10 Finland
Cellulitis of trunk
51.7
8.7
10
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
8.4
8
*
5702
FHL
Local lymph node removal (eg armpit, groin)
+∞
8.4
8
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
8.4
8
*
Z93.3
ICD-10 Finland
Colostomy status
+∞
8.4
8
*
8071/2-C51.9
ICD-O-3
Differentiated intraepithelial neoplasia of vulva, NOS
+∞
8.4
8
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
+∞
8.4
8
*
8474
FHL
Coagulation, excision, or biopsy of local change (eg, condyloma, tumor) in operating room or anesthesia
34.5
8.1
10
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.6
8.0
64
288
A46
ICD-10 Finland
Erysipelas
2.7
7.9
59
256
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.6
7.8
26
61
ZXC40
NOMESCO Finland
Use of ultrasound
25.8
7.6
10
*
XX1AT
NOMESCO Finland
Other puncture with ultrasound guidance
25.8
7.6
10
*
JFF23
NOMESCO Finland
Transversostomy
82.2
7.5
8
*
C50.99
ICD-10 Finland
Breast, unspecified
82.2
7.5
8
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.6
7.3
57
251
L03AA13
ATC
pegfilgrastim; parenteral
+∞
7.3
7
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
7.3
7
*
QB4S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in groin or genital area (from front)
+∞
7.3
7
*
8477
FHL
Vulvectomy
+∞
7.3
7
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
7.3
7
*
1844A
ICD-9 Finland
Malignant neoplasm of other and unspecified female genital organs, Vulva, unspecified
+∞
7.3
7
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
7.2
74
375
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.4
7.2
68
335
D06BB10
ATC
imiquimod; topical
5.0
6.9
21
45
N90.4
ICD-10 Finland
Leukoplakia of vulva
17.2
6.8
10
6
TPH04
NOMESCO Finland
Cathetrisation of vein
2.3
6.7
67
334
JA1AE
NOMESCO Finland
Ultrasound examination of groin and abdominal wall
9.0
6.6
13
15
N90.3
ICD-10 Finland
Dysplasia of vulva, unspecified
71.4
6.5
7
*
Z08.7
ICD-10 Finland
Follow-up examination after combined treatment for malignant neoplasm
71.4
6.5
7
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.8
6.4
17
31
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.2
6.3
32
109
KBJ10
NOMESCO Finland
Cutaneous ureteroenterostomy
+∞
6.3
6
*
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
6.3
6
*
KCC30
NOMESCO Finland
Cystectomy with excision of female internal genital organs
+∞
6.3
6
*
PJD64
NOMESCO Finland
Laparoscopic dissection of iliac lymph nodes
+∞
6.3
6
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*
YL1CD
NOMESCO Finland
Very extensive CT examination of pelvis for dose design of radiotherapy
+∞
6.3
6
*
Z51.0
ICD-10 Finland
Radiotherapy session
+∞
6.3
6
*
C51.03
ICD-10 Finland
Melanoma and labium majus
+∞
6.3
6
*
WC105
NOMESCO Finland
Simple cytostatic therapy of local tumor recidive
+∞
6.3
6
*
JFG10
NOMESCO Finland
Closure of loop colostomy without resection
27.4
6.3
8
*
J01CE08
ATC
benzathine benzylpenicillin; parenteral
12.9
6.1
10
8
A63.0
ICD-10 Finland
Anogenital (venereal) warts
7.0
6.1
14
21

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
154
90
25.06
196.55
1.7
1.3
—
—
—
0
0
300
1321
4.57
56.17
4.7
1.7
—
—
—
0
0
142
389
4.81
49.25
2.4
1.7
—
—
—
0
0
320
1619
4.12
45.97
6.0
3.5
—
—
—
0
0
161
519
4.21
44.63
3.7
2.1
0.8
0.8
mmol/l
9.20
150
460
43
38
12.36
41.93
2.1
1.7
—
—
—
0
0
105
255
5.02
41.67
1.5
1.1
—
—
—
0
0
231
1042
3.41
37.38
3.1
1.9
—
—
—
0
0
96
284
4.00
28.90
2.2
1.8
0.2
0.2
g/l
1.76
89
265
178
807
2.95
26.68
3.2
1.9
—
—
—
0
0
286
1690
2.79
25.38
5.9
3.3
34.5
35.5
g/l
2.26
272
1553
122
483
3.07
22.88
2.6
1.9
—
—
—
0
0
178
882
2.65
21.66
5.5
3.7
—
—
—
0
0
314
2083
2.56
19.89
12.1
6.4
4.2
4.2
e9/l
0.03
285
1801
293
1883
2.50
19.88
7.8
3.4
9.3
10.5
umol/l
2.31
276
1744
157
841
2.31
15.15
4.9
3.1
95.5
91.6
%
0.97
152
814
271
1822
2.16
14.66
6.8
4.4
1.2
1.2
mmol/l
0.59
248
1591
292
2027
2.18
14.47
7.3
5.0
1.2
1.2
mmol/l
1.72
246
1719
61
219
3.05
13.17
4.1
1.4
14.2
2.7
ug/l
0.65
45
171
146
812
2.16
12.48
1.5
1.3
—
—
—
0
0
25
49
5.33
12.35
1.4
1.1
—
—
—
0
0
373
2976
2.27
11.43
10.1
5.2
81.4
76.5
u/l
1.15
352
2722
229
1545
1.95
11.18
9.5
9.7
1.1
1.3
inr
4.51
63
440
234
1597
1.93
10.97
4.4
3.6
—
—
—
0
0
188
1211
1.93
10.32
4.2
3.0
7.4
7.4
ph
1.36
40
199
299
2266
1.89
9.66
5.8
3.8
6.9
6.7
mmol/l
1.00
280
2101
145
882
1.93
9.27
8.2
4.9
—
—
—
0
0
172
1113
1.86
9.06
3.6
3.1
61.0
53.7
e6/l
0.07
140
855
343
2747
1.94
9.02
6.6
5.2
25.4
5654.6
e6/l
—
8
31
207
1428
1.81
8.79
4.6
2.0
2.4
2.4
mmol/l
0.34
187
1181
60
265
2.45
8.63
8.5
5.1
—
—
—
0
0
8
0
+∞
8.36
1.0
0.0
—
—
—
0
0
42
158
2.82
8.31
1.7
1.2
—
—
—
0
0
14
24
5.98
7.90
1.0
1.0
—
—
—
0
0
85
451
2.08
7.87
4.1
3.2
1.0
1.0
mmol/l
0.17
75
400
159
1044
1.79
7.75
3.7
3.0
0.4
0.5
e6/l
0.52
127
807
271
2072
1.74
7.69
5.1
4.1
0.0
0.0
estimate
0.50
54
348
194
1357
1.74
7.55
4.3
3.7
146.4
114.7
e6/l
0.31
149
954
64
313
2.21
7.27
1.9
2.5
69.2
72.7
e9/l
0.31
43
244
76
401
2.07
7.11
8.0
5.0
0.8
1.8
mmol/l
1.18
63
317
267
2060
1.69
7.09
6.4
5.6
0.0
0.0
estimate
0.00
54
341
127
806
1.79
6.81
3.2
2.4
6.1
8.2
e6/l
0.86
115
711
78
423
2.01
6.77
2.8
2.1
1.8
1.8
%
0.19
66
371
86
485
1.95
6.67
2.6
2.3
20.4
21.8
%
0.33
64
399
43
184
2.47
6.62
4.1
3.3
7.4
7.4
ph
—
10
28
67
348
2.08
6.53
3.8
2.7
1.9
2.4
mmol/l
0.42
55
286
68
369
1.99
5.87
2.6
2.4
3.2
4.8
ug/l
1.24
56
314
89
531
1.84
5.77
2.4
2.2
2.2
2.4
g/l
1.82
75
489
149
1031
1.65
5.71
3.8
3.0
—
—
—
0
0
57
295
2.06
5.60
7.3
4.2
1.5
1.4
mmol/l
0.33
52
284
65
355
1.97
5.50
4.2
3.6
—
—
—
0
0
57
298
2.04
5.45
3.6
3.8
1.3
0.6
%
0.91
27
46
115
753
1.70
5.40
3.8
2.7
486.1
506.9
mosm/kgh2o
0.57
105
644
48
237
2.14
5.33
5.1
4.1
—
—
—
0
0
5
0
+∞
5.22
3.2
0.0
—
—
—
0
0
32
135
2.47
5.10
1.9
1.6
1.3
1.6
ug/l
0.13
25
117
35
154
2.38
5.10
5.4
3.8
—
—
—
0
0
153
1093
1.60
5.05
5.7
4.4
0.0
0.0
estimate
0.00
48
346
9
9
10.17
5.04
5.1
1.4
13.1
16.3
ug/l
—
9
9
23
84
2.83
4.85
1.3
1.4
104.3
63.6
pmol/l
1.25
23
84
58
323
1.91
4.64
5.5
2.7
1.2
1.2
mmol/l
0.22
51
265
207
1610
1.51
4.57
5.2
3.9
—
—
—
0
0
123
853
1.60
4.53
1.8
1.6
1.1
1.1
mg/l
0.02
95
666
64
371
1.84
4.53
2.6
1.8
380.7
366.0
nmol/l
0.23
54
327
55
304
1.92
4.50
5.4
4.3
—
—
—
0
0
91
586
1.69
4.49
2.5
2.2
11.3
12.8
umol/l
0.96
76
529
8
9
9.02
4.29
1.0
1.0
—
—
—
0
0
52
288
1.91
4.24
3.8
3.9
0.1
0.0
%
0.77
24
44
162
1213
1.51
4.20
3.4
2.2
57.0
57.0
u/l
0.00
147
1092
242
1971
1.47
4.12
6.7
5.6
0.2
0.2
e9/l
1.07
213
1715
375
4061
0.61
4.11
5.2
5.4
2.7
2.8
mmol/l
0.45
327
3678
235
1912
1.46
3.97
6.5
5.3
0.0
0.0
e9/l
2.20
208
1633
238
1945
1.46
3.90
6.5
5.4
1.6
1.9
e9/l
3.61
213
1690
18
65
2.84
3.90
3.3
3.1
—
—
—
0
0
55
320
1.81
3.85
2.5
1.4
65.3
67.2
g/l
1.10
48
284
233
1902
1.45
3.81
6.5
5.3
0.6
0.6
e9/l
0.43
206
1622
246
2037
1.44
3.68
5.3
4.1
0.0
0.0
estimate
0.00
56
354
16
56
2.92
3.66
2.7
2.6
—
—
—
0
0
47
265
1.86
3.64
1.4
1.3
—
—
—
0
0
49
282
1.82
3.56
3.6
3.8
0.9
0.4
%
0.68
19
40
324
2835
1.47
3.55
6.3
4.9
—
—
—
0
0
135
1004
1.49
3.53
4.7
4.0
—
—
—
0
0
45
253
1.86
3.52
3.3
2.4
123.0
126.9
g/l
0.55
45
244
6
6
10.11
3.50
3.0
1.5
—
—
—
0
0
49
284
1.81
3.49
3.3
3.9
0.0
2.0
%
0.49
21
43
110
787
1.52
3.45
5.1
4.1
—
—
—
0
0
32
161
2.06
3.43
3.8
2.8
24.0
24.7
mmol/l
0.46
27
142
38
205
1.93
3.37
3.6
2.5
25.5
25.6
mmol/l
0.08
38
196
363
3929
0.66
3.35
4.7
4.7
1.5
1.6
mmol/l
1.38
316
3551
6
7
8.66
3.27
1.3
1.4
0.2
0.2
e9/l
—
6
7
10
28
3.63
3.21
2.2
2.1
—
—
—
0
0
161
1259
1.43
3.19
7.0
5.5
—
—
—
0
0
137
1042
1.45
3.15
2.5
2.3
3.1
3.1
mg/l
0.08
107
876
41
233
1.83
3.12
2.4
2.4
9.9
10.6
g/l
0.37
36
222
369
3969
0.66
3.09
4.8
4.7
4.7
4.8
mmol/l
0.37
331
3607
18
74
2.49
3.08
3.9
3.3
60.9
60.2
%
0.07
18
74
207
1703
1.39
3.02
7.2
5.6
0.6
0.7
%
3.02
186
1559
67
445
1.59
2.91
1.7
1.4
—
—
—
0
0
213
1769
1.38
2.90
7.3
5.8
8.8
8.4
%
1.04
193
1632
167
1333
1.39
2.89
3.2
2.9
1506.5
1278.8
ng/l
0.38
136
1123
11
36
3.11
2.82
1.7
1.4
38.6
38.1
u/l
0.02
11
25
31
167
1.92
2.79
10.2
7.0
—
—
—
0
0
57
368
1.63
2.78
3.0
2.0
5.7
5.8
umol/l
0.03
44
309
5
6
8.41
2.75
4.2
1.0
—
—
—
0
0
11
37
3.02
2.71
1.0
1.1
—
—
—
0
0
352
3799
0.70
2.68
7.0
6.2
40.7
40.1
mmol/mol
0.45
314
3492
211
1766
1.36
2.67
7.1
5.5
2.7
2.9
%
0.59
192
1620
49
308
1.66
2.66
1.4
1.4
—
—
—
0
0
198
1642
1.36
2.66
13.2
8.7
0.0
0.0
e9/l
0.48
173
1341
214
1799
1.35
2.62
7.3
5.7
23.8
28.3
%
6.46
194
1653
18
81
2.27
2.57
3.1
2.3
14.4
16.4
%
1.33
12
35
26
136
1.97
2.56
4.3
3.2
—
—
—
0
0
193
1604
1.35
2.52
4.8
3.9
62.5
50.3
ng/l
0.10
150
1140
97
722
1.43
2.46
1.4
1.3
2.1
2.4
g/l
1.18
49
402
413
3883
1.56
2.42
25.4
12.8
28.6
20.6
mg/l
4.99
366
3004
11
40
2.79
2.39
1.0
1.1
4.5
3.5
u/ml
—
6
15
18
84
2.19
2.38
1.8
1.8
—
—
—
0
0
8
22
3.68
2.37
2.5
1.1
—
36.6
—
0
8
57
386
1.54
2.30
3.2
2.9
96.8
80.0
ng/l
0.64
38
331
110
847
1.39
2.30
4.0
2.2
2.5
2.5
mmol/l
3.00
102
742
16
72
2.27
2.30
3.9
3.0
4.5
4.4
e9/l
0.09
16
72
18
86
2.14
2.25
1.2
1.1
—
120.0
—
0
6
5
149
0.33
2.19
2.0
1.5
—
—
—
0
0
45
294
1.59
2.13
2.3
1.4
—
—
—
0
0
354
3781
0.73
2.07
4.3
4.2
1.4
1.3
mmol/l
1.64
312
3373
5
10
5.04
2.07
1.6
1.3
—
—
—
0
0
39
248
1.62
2.06
2.2
3.0
4.6
4.5
pmol/l
0.18
33
211
22
120
1.87
1.96
3.4
2.5
0.5
0.2
g/l
—
8
25
207
1784
1.29
1.96
6.7
5.4
59.6
57.3
%
1.52
186
1645
90
1152
0.73
1.96
1.6
1.6
1.5
1.3
mmol/l
0.90
72
969
361
3829
0.75
1.83
6.1
5.5
2.1
2.3
mu/l
0.18
333
3477
20
109
1.87
1.80
3.1
3.3
—
—
—
0
0
158
1331
1.28
1.75
2.8
2.1
191.8
155.4
u/l
0.50
149
1248
5
13
3.87
1.72
1.0
1.1
—
—
—
0
0
5
13
3.87
1.72
1.2
1.2
—
—
—
0
0
311
2847
1.28
1.71
4.5
3.9
—
—
—
0
0
15
75
2.03
1.71
4.3
1.2
—
—
—
0
0
6
19
3.18
1.66
1.0
1.9
—
—
—
0
0
7
25
2.83
1.65
2.0
2.0
—
—
—
0
0
11
49
2.27
1.64
1.0
1.1
—
—
—
0
0
5
14
3.60
1.62
1.4
1.1
—
—
—
0
0
10
44
2.30
1.54
2.0
2.8
—
—
—
0
0
116
957
1.28
1.49
6.0
4.4
1.0
1.0
kg/l
—
9
147
9
38
2.39
1.46
1.1
2.1
34.0
32.4
pg
—
9
38
7
28
2.52
1.45
1.0
1.1
—
—
—
0
0
12
224
0.52
1.42
1.2
1.4
—
—
—
0
0
48
349
1.42
1.42
1.4
1.5
—
—
—
0
0
9
41
2.22
1.37
1.1
1.1
—
—
—
0
0
26
167
1.59
1.37
1.1
1.2
—
—
—
0
0
5
17
2.96
1.36
1.2
1.2
5.4
7.6
mmol/l
—
5
17
126
1063
1.25
1.35
1.5
1.6
21.0
22.3
nmol/l
0.38
106
877
53
398
1.37
1.31
1.4
1.2
—
—
—
0
0
25
161
1.58
1.31
1.8
1.2
0.3
1.0
u/ml
—
6
12
5
18
2.80
1.29
8.2
1.7
7.3
3.7
nmol/l
—
5
18
12
62
1.96
1.28
2.3
2.3
—
—
—
0
0
382
3981
0.78
1.27
5.2
5.0
6.1
5.9
mmol/l
1.51
337
3588
69
544
1.32
1.25
16.9
25.7
1.3
1.3
inr
0.14
11
71
109
918
1.24
1.18
1.9
1.8
1142.2
1225.8
nmol/l
0.38
81
667
5
20
2.52
1.15
1.0
1.3
—
—
—
0
0
427
4137
1.38
1.15
28.3
15.4
139.3
139.8
mmol/l
3.47
418
4016
7
30
2.35
1.12
3.1
1.2
—
—
—
0
0
9
163
0.54
1.10
1.3
1.7
—
—
—
0
0
13
74
1.78
1.07
1.5
2.2
—
—
—
0
0
6
123
0.48
1.06
1.0
1.1
—
—
—
0
0
7
33
2.14
1.06
1.3
1.7
—
—
—
0
0
427
4145
1.36
1.05
28.2
15.5
3.9
4.0
mmol/l
0.33
418
4014
35
257
1.39
1.02
3.1
2.8
4.9
4.0
e9/l
0.53
20
184
53
417
1.31
1.00
5.8
3.6
—
—
—
0
0
30
216
1.42
0.98
1.6
1.2
—
—
—
0
0
0
31
0.00
0.96
0.0
3.3
—
9.0
—
0
23
321
3377
0.84
0.95
5.4
4.5
15.5
15.0
pmol/l
1.48
296
3054
14
85
1.67
0.95
3.9
2.5
25.6
51.5
ug/min
—
8
56
7
37
1.91
0.94
4.3
3.3
—
—
—
0
0
13
78
1.69
0.92
5.3
1.3
—
—
—
0
0
8
43
1.88
0.87
2.9
2.9
—
—
—
0
0
63
759
0.80
0.86
1.4
1.3
1.5
13.6
u/ml
4.79
21
266
6
31
1.95
0.84
1.3
1.4
—
—
—
0
0
6
31
1.95
0.84
1.3
1.4
—
—
—
0
0
6
31
1.95
0.84
1.0
1.5
—
—
—
0
0
6
31
1.95
0.84
1.3
1.4
—
—
—
0
0
6
31
1.95
0.84
1.3
1.4
—
—
—
0
0
6
31
1.95
0.84
1.2
1.4
—
—
—
0
0
111
972
1.19
0.82
1.7
1.7
410.1
17357980.1
pmol/l
0.80
88
772
13
82
1.60
0.79
1.5
1.2
—
—
—
0
0
120
1064
1.17
0.77
5.0
3.7
—
—
—
0
0
12
185
0.64
0.77
1.1
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
9
53
1.71
0.76
1.2
1.3
—
—
—
0
0
9
54
1.68
0.75
1.2
1.1
—
—
—
0
0
18
125
1.46
0.73
9.1
5.3
—
—
—
0
0
7
41
1.72
0.70
1.3
1.2
—
—
—
0
0
7
117
0.59
0.68
3.1
2.5
—
—
—
0
0
5
27
1.86
0.68
1.4
1.0
—
—
—
0
0
413
4028
1.22
0.68
22.3
12.8
—
—
—
0
0
23
302
0.75
0.64
1.2
1.3
—
—
—
0
0
109
1213
0.87
0.63
4.0
3.1
—
—
—
0
0
8
49
1.64
0.62
1.0
1.1
—
—
—
0
0
8
49
1.64
0.62
1.3
1.2
—
—
—
0
0
8
50
1.61
0.61
1.3
1.2
—
—
—
0
0
8
50
1.61
0.61
1.3
1.2
—
—
—
0
0
8
50
1.61
0.61
1.3
1.2
—
—
—
0
0
333
3451
0.88
0.61
25.6
14.7
37.0
38.6
%
1.77
201
2229
8
51
1.58
0.60
1.3
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.4
—
129.2
—
0
20
7
114
0.61
0.58
1.3
1.1
—
—
—
0
0
90
802
1.15
0.55
3.7
4.2
67.6
333.3
ng/l
1.93
77
655
16
116
1.39
0.55
1.2
1.8
3.4
5.4
iu/l
—
5
38
6
40
1.51
0.51
1.0
1.1
—
—
—
0
0
15
200
0.74
0.49
2.4
2.1
—
—
—
0
0
7
47
1.50
0.47
1.6
3.0
—
—
—
0
0
7
48
1.47
0.47
1.9
1.5
509.7
313.6
mu/l
—
7
43
143
1330
1.11
0.45
3.4
3.0
5.7
6.2
mmol/l
0.78
120
1095
26
211
1.25
0.44
1.8
1.3
—
—
—
0
0
69
771
0.88
0.43
1.4
1.3
40.0
38.3
iu/ml
0.03
17
249
8
56
1.44
0.42
3.9
1.8
46.5
58.8
%
—
8
56
133
1236
1.11
0.42
4.9
4.0
—
—
—
0
0
10
70
1.44
0.42
1.4
1.2
—
—
—
0
0
54
475
1.15
0.41
2.2
1.9
164.0
136.0
ug/g
0.22
42
370
0
16
0.00
0.41
0.0
12.3
—
0.7
—
0
16
8
59
1.36
0.41
1.6
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
0
17
0.00
0.40
0.0
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
1.2
—
—
—
0
0
324
3145
1.10
0.40
29.0
15.9
14.0
13.7
%
3.31
318
3054
0
18
0.00
0.40
0.0
1.1
—
0.6
—
0
13
13
97
1.35
0.40
1.7
1.2
1199.4
467.7
mg/l
0.62
13
90
10
71
1.42
0.39
1.0
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.8
—
—
—
0
0
18
144
1.26
0.36
13.4
8.2
—
—
—
0
0
32
371
0.85
0.34
1.3
1.7
—
—
—
0
0
98
908
1.10
0.34
1.3
1.3
0.8
1.7
u/ml
1.38
24
236
6
45
1.34
0.34
1.5
1.2
—
—
—
0
0
137
1296
1.08
0.30
3.6
3.0
436.4
142.0
mg/l
0.33
92
725
7
55
1.28
0.30
2.6
1.9
90.6
90.1
%
—
7
55
9
117
0.76
0.27
1.0
1.1
—
—
—
0
0
144
1371
1.07
0.27
4.6
3.8
10.5
6.1
mg/mmol
0.42
94
773
25
288
0.86
0.26
3.2
3.3
—
—
—
0
0
9
72
1.25
0.25
1.8
1.2
—
—
—
0
0
6
81
0.74
0.24
1.2
1.5
—
—
—
0
0
193
1865
1.06
0.23
2.1
2.1
98.0
97.6
pmol/l
0.02
107
834
5
39
1.29
0.23
1.6
1.7
2.7
98.1
u/ml
—
5
39
25
284
0.87
0.22
2.6
2.5
—
17.7
—
0
7
14
116
1.21
0.22
1.3
1.4
268.8
306.9
ug/g
—
6
63
0
10
0.00
0.21
0.0
2.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.6
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
312
3061
1.06
0.21
4.8
4.4
16.4
13.5
mm/h
2.53
280
2804
176
1704
1.05
0.19
3.1
2.7
160.1
90.2
ug/l
3.19
154
1538
24
269
0.89
0.18
2.2
2.5
—
—
—
0
0
7
62
1.13
0.17
1.4
1.1
—
—
—
0
0
35
321
1.10
0.17
1.5
1.4
—
—
—
0
0
97
928
1.06
0.16
3.3
2.2
357.0
6817.7
umol/l
3.78
82
769
23
254
0.90
0.14
1.4
1.4
—
46.5
—
0
10
56
592
0.94
0.14
1.1
1.2
—
—
—
0
0
421
4183
1.07
0.12
14.7
9.3
24.1
22.5
u/l
0.77
410
3992
24
261
0.92
0.12
7.0
3.9
—
—
—
0
0
32
298
1.08
0.12
1.3
1.5
—
—
—
0
0
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
5
44
1.14
0.10
1.2
1.1
—
—
—
0
0
35
331
1.06
0.09
1.1
1.2
—
—
—
0
0
5
63
0.79
0.08
1.4
1.5
—
—
—
0
0
5
63
0.79
0.08
1.8
1.2
18.1
18.8
u/l
—
5
56
429
4307
0.95
0.07
36.5
19.5
126.6
131.4
g/l
10.32
422
4226
429
4306
0.95
0.06
36.2
19.4
4.3
4.4
e12/l
5.27
413
4152
429
4306
0.95
0.06
36.2
19.4
6.7
6.6
e9/l
0.20
412
4150
429
4306
0.95
0.06
36.1
19.3
260.9
259.3
e9/l
0.17
414
4168
429
4306
0.95
0.06
36.0
19.3
30.1
30.2
pg
0.44
421
4224
429
4305
0.96
0.06
36.0
19.3
91.2
91.2
fl
0.03
421
4223
418
4170
1.02
0.02
28.4
14.8
74.0
71.8
umol/l
0.90
418
4170
16
152
1.05
0.02
1.6
1.5
—
—
—
0
0
13
135
0.96
0.00
1.3
1.2
—
—
—
0
0
16
155
1.03
0.00
1.3
1.4
—
—
—
0
0
54
537
1.01
0.00
1.6
1.3
967.3
651.4
titre
0.31
11
140
29
288
1.01
0.00
1.2
1.2
114.3
132.3
iu/ml
—
7
118
0
9
0.00
0.00
0.0
1.2
—
1.6
—
0
9
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
5
58
0.86
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
4.9
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
5.1
2.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
17.6
—
0
5
6
61
0.98
0.00
1.2
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
8
89
0.90
0.00
1.5
1.6
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_VULVA_EXALLC – Malignant neoplasm of vulva, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).