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Carcinoma in situ of breast, other/unspecified

CD2_INSITU_BREAST_NOS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

only females

-

2. Check conditions

None

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D05.7&, D05.9&
  • Hospital discharge: ICD-9 2330
  • Cause of death: ICD-10 D05.7&, D05.9&
  • Cause of death: ICD-9 2330

2 out of 7 registries used, show all original rules.

-

4. Check minimum number of events

None

-

5. Include endpoints

None

-

6. Filter based on genotype QC (FinnGen only)

None

-

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

No upset plot: script not run.

No upset table: script not run.

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 471 471 -
Unadjusted period prevalence (%) 0.16 0.16 -
Median age at first event (years) 58.47 58.47 -

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
414
Matched controls
4140
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D05.9
ICD-10 Finland
Carcinoma in situ of breast, unspecified
+∞
323.0
301
*
D05.1
ICD-10 Finland
Intraductal carcinoma in situ
5230.1
258.6
222
*
PJA12
NOMESCO Finland
Sentinel node biopsy
1094.5
206.4
185
*
8500/3-C50.9
ICD-O-3
Infiltrating duct carcinoma, NOS, of breast, NOS
+∞
173.5
154
*
8500/2-C50.9
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of breast, NOS
+∞
172.2
153
*
HAC20
NOMESCO Finland
Total mastectomy
2103.1
154.3
140
*
115
Kela drug reimbursment
Breast cancer
+∞
154.0
138
*
HAB40
NOMESCO Finland
Wedge excision of mammary gland
212.5
152.4
150
11
C50.41
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, ductal tumor
+∞
116.3
106
*
C50.99
ICD-10 Finland
Breast, unspecified
+∞
111.6
102
*
HA003
NOMESCO Finland
Radiotherapy after partial ablation of mammary gland
+∞
103.6
95
*
HA1AA
NOMESCO Finland
X-ray mammography
26.7
96.4
137
75
HA1AE
NOMESCO Finland
Ultrasound examination of mammary glands
37.5
92.6
119
44
HAE10
NOMESCO Finland
Reconstruction of breast using graft or flap
+∞
80.9
75
*
L02BG04
ATC
letrozole; oral
309.1
77.3
76
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
865.8
75.7
72
*
D05.7
ICD-10 Finland
Other carcinoma in situ of breast
+∞
75.3
70
*
H02AB02
ATC
dexamethasone; systemic
66.5
74.5
85
16
YG1BD
NOMESCO Finland
Extensive CT examination of thorax for dose design of radiotherapy
+∞
70.9
66
*
HAE20
NOMESCO Finland
Reconstruction of areola and mamilla using graft or flap
+∞
68.7
64
*
PJD52
NOMESCO Finland
Block dissection of axillary lymph nodes
765.7
68.0
65
*
C50
ICD-10 Finland
Malignant neoplasm of breast
+∞
66.5
62
*
L02BA01
ATC
tamoxifen; oral
+∞
63.2
59
*
TQW20
NOMESCO Finland
Tatoe
+∞
59.9
56
*
A04AA02
ATC
granisetron; systemic, transdermal
655.9
59.2
57
*
2330A
ICD-9 Finland
Carcinoma in situ of breast and genito-urinary system, Breast
+∞
57.7
54
*
HA6AA
NOMESCO Finland
Extra corporeal mammography of operated mammary gland
41.2
43.4
54
15
WB203
NOMESCO Finland
Simple adjuvant hormone therapy of malignancy
+∞
41.3
39
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
5.1
41.1
157
442
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
40.3
38
*
C50.90
ICD-10 Finland
Malignant tumor in other or unspecified location in mammary gland without histology
+∞
39.2
37
*
HAC15
NOMESCO Finland
Subcutaneous mastectomy with excision of mamilla
+∞
38.1
36
*
C50.49
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, other or undeterminated histology
+∞
36.0
34
*
C50.91
ICD-10 Finland
Malignant tumor in another specified localization in ductal mammary gland
+∞
36.0
34
*
C50.40
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, no histological veryfication
+∞
34.9
33
*
8503/2-C50.9
ICD-O-3
Noninfiltrating intraductal papillary adenocarcinoma of breast, NOS
+∞
34.9
33
*
XX3DW
NOMESCO Finland
Time consuming IT work
9.9
34.4
72
86
HAB99
NOMESCO Finland
Other partial excision of mammary gland
35.0
34.3
44
14
HA4AT
NOMESCO Finland
Labeling mammary gland pathology with ultrasound guidance
61.2
33.9
39
7
ZZR10
NOMESCO Finland
Flap of skin and muscle
+∞
33.8
32
*
HAB00
NOMESCO Finland
Excision of lesion of mammary gland
15.2
33.4
56
42
C50.11
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,ductal tumor
+∞
32.7
31
*
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
32.7
31
*
ZX080
NOMESCO Finland
Image guided radiotherapy
+∞
32.7
31
*
D05.0
ICD-10 Finland
Lobular carcinoma in situ
+∞
31.7
30
*
C50.81
ICD-10 Finland
Overall malignant tumor of the mammary gland, ductal tumor
+∞
31.7
30
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
31.7
30
*
A03FA01
ATC
metoclopramide; systemic, rectal
4.5
29.8
123
357
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.6
29.7
177
710
X76
ICPC
Malignant neoplasm breast female
+∞
29.5
28
*
Z85.3
ICD-10 Finland
Personal history of malignant neoplasm of breast
+∞
29.5
28
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
28.5
27
*
C50.4
ICD-10 Finland
Malignant neoplasm: Upper-outer quadrant of breast
+∞
28.5
27
*
Z31.5
ICD-10 Finland
Genetic counselling
11.0
28.2
55
57
HAB50
NOMESCO Finland
Partial excision of mammary gland with reconstructive operation
149.7
27.0
28
*
C50.51
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, ductal tumor
+∞
26.3
25
*
THW99
NOMESCO Finland
Other minor procedure in surgery of mammary gland
53.7
25.6
30
6
C50.21
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland,ductal tumor
+∞
25.3
24
*
N63
ICD-10 Finland
Unspecified lump in breast
6.8
24.9
66
113
9707
FHL
Ablation of mammae and removal of axillary lymph nodes
+∞
24.2
23
*
9703
FHL
Breast resection
33.4
24.1
31
10
HAE99
NOMESCO Finland
Other reconstruction of breast
132.7
23.9
25
*
PJD42
NOMESCO Finland
Excision of axillary lymph nodes
132.7
23.9
25
*
JN4BD
NOMESCO Finland
Extensive body CT
7.9
23.9
56
80
A04AD12
ATC
aprepitant; systemic
242.8
22.9
23
*
N60.9
ICD-10 Finland
Benign mammary dysplasia, unspecified
47.9
22.6
27
6
YG1AD
NOMESCO Finland
CT examination of thorax for dose design of radiotherapy
+∞
22.1
21
*
PJ5AN
NOMESCO Finland
Localisation of sentinell lymphnode with isotope imaging
231.7
21.8
22
*
HAD30
NOMESCO Finland
Reduction mammoplasty with transposition of areola
7.8
21.7
51
73
NK6AN
NOMESCO Finland
Total body bone isotope imaging
81.1
20.9
23
*
Z08.0
ICD-10 Finland
Follow-up examination after surgery for malignant neoplasm
57.9
19.1
22
*
HA1AT
NOMESCO Finland
Biopsy of mammary glands with ultrasound guidance
36.3
19.1
24
7
L02BG06
ATC
exemestane; oral
+∞
18.9
18
*
HAE05
NOMESCO Finland
Reconstruction of breast using soft tissue and prosthesis
+∞
18.9
18
*
130
Kela drug reimbursment
Malignant tumour
+∞
18.9
18
*
HAD99
NOMESCO Finland
Other plastic operation on breast
73.4
18.9
21
*
HA1CG
NOMESCO Finland
Extensive MRI examination of mammary gland with high intensity magnet
73.4
18.9
21
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
198.6
18.7
19
*
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
12.3
18.3
33
29
YX9AD
NOMESCO Finland
Other CT eamination for dose design of radiotherapy
69.8
17.9
20
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
17.8
17
*
8520/3-C50.9
ICD-O-3
Lobular carcinoma, NOS, of breast, NOS
+∞
17.8
17
*
Z80.3
ICD-10 Finland
Family history of malignant neoplasm of breast
19.7
17.5
26
14
WX702
NOMESCO Finland
Supraglottic ventilation device
5.3
16.9
53
111
8500/3-C50.4
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-outer quadrant of breast
+∞
16.8
16
*
L02BG03
ATC
anastrozole; oral
+∞
16.8
16
*
ZZF00
NOMESCO Finland
Graft of adipose tissue
176.8
16.6
17
*
HA013
NOMESCO Finland
Radiotherapy after total ablation of mammary gland
+∞
15.7
15
*
D05
ICD-10 Finland
Carcinoma in situ of breast
+∞
15.7
15
*
C50.31
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, ductal tumor
+∞
15.7
15
*
C50.42
ICD-10 Finland
Malignant tumor of the upper outer quadrant of the mammary gland, lobular tumor
+∞
15.7
15
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
15.7
15
*
ZZQ10
NOMESCO Finland
Free microvascular graft of skin and muscle
166.0
15.6
16
*
L03AA14
ATC
lipegfilgrastim; parenteral
+∞
14.7
14
*
1744A
ICD-9 Finland
Malignant neoplasm of female breast, Upper-outer quadrant
+∞
14.7
14
*
C50.19
ICD-10 Finland
Malignant tumor of the central part of the mammary gland, other or undeterminated histology
+∞
14.7
14
*
HA6BA
NOMESCO Finland
Breast tomosynthesis specimen
155.2
14.6
15
*
HA1DG
NOMESCO Finland
Very extensive MRI examination of mammary gland with high intensity magnet
155.2
14.6
15
*
5702
FHL
Local lymph node removal (eg armpit, groin)
155.2
14.6
15
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
155.2
14.6
15
*
TQB05
NOMESCO Finland
Puncture of skin of trunk
44.1
14.2
17
*
C50.89
ICD-10 Finland
Overall malignant tumor of the mammary gland, other or undeterminated histology
+∞
13.6
13
*
9706
FHL
Ablation mammae, includes axillary exploration
+∞
13.6
13
*
C50.9
ICD-10 Finland
Malignant neoplasm: Breast, unspecified
+∞
13.6
13
*
HAE00
NOMESCO Finland
Reconstruction of breast using prosthesis
144.5
13.5
14
*
WX402
NOMESCO Finland
General anaesthesia
3.1
13.0
80
300
C50.29
ICD-10 Finland
Malignant tumor of the upper inner quadrant of the mammary gland, other or undeterminated histology
+∞
12.6
12
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.3
12.4
47
121
HAD40
NOMESCO Finland
Mastopexy
38.8
12.3
15
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
31.0
11.7
15
5
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
11.7
189
1179
C50.39
ICD-10 Finland
Malignant tumor of the lower inner quadrant of the mammary gland, other or undeterminated histology
+∞
11.5
11
*
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
11.5
11
*
XX1XN
NOMESCO Finland
Other isotope examination
+∞
11.5
11
*
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
10.9
116
593
9702
FHL
Breast exploration and possible tumor removal
7.0
10.9
26
39
QBA00
NOMESCO Finland
Puncture of skin of trunk
61.6
10.7
12
*
HAD60
NOMESCO Finland
Replacement of prosthetic implant in breast
112.7
10.5
11
*
8500/2-C50.4
ICD-O-3
Intraductal carcinoma, noninfiltrating, NOS, of upper-outer quadrant of breast
+∞
10.5
10
*
L01BC06
ATC
capecitabine; oral
+∞
10.5
10
*
YX9BD
NOMESCO Finland
Other extensive CT eamination for dose design of radiotherapy
+∞
10.5
10
*
C50.59
ICD-10 Finland
Malignant tumor of the lower outer quadrant of the mammary gland, other or undeterminated histology
+∞
10.5
10
*
ZZQ00
NOMESCO Finland
Free microvascular graft of skin
+∞
10.5
10
*
Z42.1
ICD-10 Finland
Follow-up care involving plastic surgery of breast
33.5
10.4
13
*
D48.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Breast
7.5
10.1
23
32
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
4.7
10.1
34
78
HWD00
NOMESCO Finland
Reoperation for deep haemorrhage in surgery of mammary gland
26.7
9.9
13
5
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
102.3
9.5
10
*
HA1BG
NOMESCO Finland
MRI examination of mammary gland with high intensity magnet
+∞
9.4
9
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
9.4
9
*
HAC10
NOMESCO Finland
Subcutaneous mastectomy with preservation of mamilla
+∞
9.4
9
*
C54.11
ICD-10 Finland
Adenocarcinoma of the endometrium
+∞
9.4
9
*
C50.00
ICD-10 Finland
Malignant tumor of nipple and areola, no histological veryfication
+∞
9.4
9
*
1749X
ICD-9 Finland
Malignant neoplasm of female breast, Breast (female), unspecified
+∞
9.4
9
*
C50.10
ICD-10 Finland
Malignant tumor of the central part of the mammary gland, no histological veryfication
+∞
9.4
9
*
Z08.7
ICD-10 Finland
Follow-up examination after combined treatment for malignant neoplasm
+∞
9.4
9
*
QBB10
NOMESCO Finland
Major dressing of wound of skin of trunk
6.5
9.2
23
37
HAA10
NOMESCO Finland
Biopsy of mammary gland
10.4
9.1
17
17
QB2S1
NOMESCO Finland
Photography of skin or subcutaneous tissue in chest
37.6
9.1
11
*
TQW99
NOMESCO Finland
Other minor procedure on skin
5.1
8.8
27
56
WZC30
NOMESCO Finland
Teaching
3.0
8.7
53
196
JN4CD
NOMESCO Finland
Very extensive body CT
9.3
8.6
17
19
HA1AE
SPAT
NA
7.6
8.5
19
26
HA4ST
NOMESCO Finland
Labeling mammary gland pathology with sterotactic guidance
28.2
8.5
11
*
HA1TE
NOMESCO Finland
Supplementary or limited ultrasound examination of mammary glands
28.2
8.5
11
*
ZSH00
NOMESCO Finland
Procedure related to previous procedure classified in chapter H
91.8
8.4
9
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
91.8
8.4
9
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
91.8
8.4
9
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
8.4
8
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
8.4
8
*
PJ5YQ
NOMESCO Finland
NA
+∞
8.4
8
*
HAD20
NOMESCO Finland
Liposuction of breast
+∞
8.4
8
*
8500/3-C50.5
ICD-O-3
Infiltrating duct carcinoma, NOS, of lower-outer quadrant of breast
+∞
8.4
8
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
8.4
8
*
ZX013
NOMESCO Finland
Radiotherapy with large shaped fields - SSD therapy
+∞
8.4
8
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
8.4
8
*
QBE30
NOMESCO Finland
Excision and repair of surgical scar in trunk
34.1
8.1
10
*
WF002
NOMESCO Finland
Radical radiotherapy
45.8
7.7
9
*
HA3ST
NOMESCO Finland
Removal of lesion of breast with radiological guidance
25.5
7.6
10
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
81.5
7.4
8
*
C50.1
ICD-10 Finland
Malignant neoplasm: Central portion of breast
+∞
7.3
7
*
8520/2-C50.9
ICD-O-3
Lobular carcinoma in situ, NOS, of breast, NOS
+∞
7.3
7
*
HA1SA
NOMESCO Finland
Expansion mammography
+∞
7.3
7
*
WB133
NOMESCO Finland
Very demanding adjuvant cytostatic therapy
+∞
7.3
7
*
C50.80
ICD-10 Finland
Overall malignant tumor of the mammary gland, no histological veryfication
+∞
7.3
7
*
I97.2
ICD-10 Finland
Postmastectomy lymphoedema syndrome
+∞
7.3
7
*
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
+∞
7.3
7
*
HAD50
NOMESCO Finland
Removal of prosthetic implant from breast
20.4
7.2
10
5
PJ3AT
NOMESCO Finland
Cytology of lymphnode with ultrasound guidance
40.7
6.8
8
*
XX2AT
NOMESCO Finland
Other injection with ultrasound examination
40.7
6.8
8
*
D24
ICD-10 Finland
Benign neoplasm of breast
5.3
6.7
19
37
X21
ICPC
Breast sympt/compl female other
6.1
6.7
17
29
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
12.5
6.6
11
9
HA1AA
SPAT
NA
5.2
6.6
19
38
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
3.8
6.5
26
72
9719
FHL
Other measure in this category
70.9
6.4
7
*
2393A
ICD-9 Finland
Neoplasm of unspecified nature, Breast
14.6
6.4
10
7
ZXA05
NOMESCO Finland
Left side
1.8
6.4
121
761
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
6.3
6
*
394
Kela drug reimbursment
Palbociclib
+∞
6.3
6
*
C50.01
ICD-10 Finland
Malignant tumor of nipple and areola, ductal tumor
+∞
6.3
6
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
6.3
6
*
WB401
NOMESCO Finland
Simple antibody therapy of primary tumour
+∞
6.3
6
*
8380/3-C54.1
ICD-O-3
Endometrioid adenocarcinoma, NOS, of endometrium
+∞
6.3
6
*
1501
Kela drug reimbursment
Palbociclib
+∞
6.3
6
*
L01XE33
ATC
[U] palbociclib; oral
+∞
6.3
6
*
8500/3-C50.2
ICD-O-3
Infiltrating duct carcinoma, NOS, of upper-inner quadrant of breast
+∞
6.3
6
*
HA2AT
NOMESCO Finland
Cytology of mammary gland with ultrasound guidance
+∞
6.3
6
*
HA3AT
NOMESCO Finland
Pucture of mammary gland cyst with ultrasound examination
+∞
6.3
6
*
C50.12
ICD-10 Finland
Malignant tumor of the central part of the mammary gland,lobular tumor
+∞
6.3
6
*
C50.5
ICD-10 Finland
Malignant neoplasm: Lower-outer quadrant of breast
+∞
6.3
6
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
+∞
6.3
6
*
A04AA01
ATC
ondansetron; systemic, rectal
4.4
6.0
20
47

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
133
107
16.93
142.13
1.4
1.3
—
—
—
0
0
80
48
19.87
98.36
1.4
1.1
—
—
—
0
0
121
282
5.43
51.00
1.4
1.1
—
—
—
0
0
251
1406
2.68
24.37
2.5
1.7
—
—
—
0
0
234
1364
2.42
19.58
3.6
2.1
2.4
2.4
mmol/l
0.26
216
1132
71
224
3.55
19.08
5.0
1.4
4.3
2.6
ug/l
1.42
60
176
390
3014
2.71
15.43
9.1
5.2
73.8
76.0
u/l
0.92
362
2763
276
1870
2.15
14.52
7.2
3.3
9.5
10.6
umol/l
1.39
257
1739
79
317
2.79
13.97
4.1
2.6
1.2
1.2
mmol/l
0.43
62
257
193
1205
2.02
11.97
4.4
3.0
7.4
7.4
ph
0.59
53
196
239
1654
1.90
10.58
3.6
3.4
—
—
—
0
0
11
11
10.22
9.57
1.0
1.0
—
—
—
0
0
149
914
1.92
9.27
6.8
4.8
—
—
—
0
0
67
303
2.41
9.16
3.9
4.3
—
—
—
0
0
279
2115
1.78
8.44
10.0
6.5
3.5
4.1
e9/l
6.23
258
1833
49
214
2.44
7.21
2.1
1.5
22.0
21.6
u/ml
0.02
44
204
157
1048
1.75
7.11
2.1
1.9
—
—
—
0
0
241
1827
1.65
6.66
5.0
4.4
1.2
1.2
mmol/l
0.05
208
1605
222
1680
1.61
5.96
10.6
8.5
0.0
0.0
e9/l
0.04
183
1376
88
537
1.79
5.28
2.4
2.2
0.8
0.8
mmol/l
0.36
80
490
253
2023
1.54
5.04
5.9
4.9
1.2
1.2
mmol/l
0.70
183
1715
19
63
3.10
4.72
3.3
3.6
—
—
—
0
0
23
95
2.49
3.86
3.4
1.8
241.8
77.5
u/ml
0.33
18
81
6
5
12.13
3.77
3.2
1.4
—
—
—
0
0
171
1319
1.47
3.74
3.2
3.1
—
—
—
0
0
49
281
1.83
3.60
2.0
1.8
0.2
0.2
g/l
1.52
42
264
363
3252
1.51
3.44
19.0
14.7
13.6
13.7
%
0.28
351
3166
112
809
1.50
3.35
2.8
2.2
2.5
2.5
mmol/l
0.02
106
699
143
1821
0.69
3.32
2.0
2.0
99.5
99.3
pmol/l
0.02
67
828
331
2926
1.44
3.24
4.0
3.8
—
—
—
0
0
161
1256
1.43
3.23
4.2
5.8
—
—
—
0
0
57
355
1.69
3.17
2.8
1.9
5.7
5.2
umol/l
0.16
43
305
106
1410
0.68
3.06
3.9
3.7
10.4
6.7
mg/mmol
0.30
51
782
111
828
1.45
2.79
1.4
1.3
—
—
—
0
0
17
73
2.38
2.68
2.8
2.3
16.6
16.4
%
0.07
12
33
18
366
0.47
2.61
2.2
3.4
—
—
—
0
0
383
3535
1.45
2.52
16.3
13.8
39.4
38.9
%
0.68
250
2337
107
1380
0.71
2.51
3.0
2.9
5.5
6.3
mmol/l
1.72
81
1160
103
1336
0.71
2.49
2.8
3.0
859.0
204.6
mg/l
0.36
50
731
16
70
2.33
2.44
2.5
2.1
—
—
—
0
0
198
1660
1.33
2.40
4.3
3.3
36.3
35.8
g/l
0.71
179
1529
16
71
2.30
2.37
3.0
4.1
2.3
3.4
mmol/l
—
10
55
16
71
2.30
2.37
3.0
4.2
4.8
5.2
kpa
1.45
16
71
16
71
2.30
2.37
3.0
4.2
8.4
8.2
kpa
0.13
16
71
436
4148
1.69
2.35
14.7
11.8
—
—
—
0
0
371
3950
0.71
2.25
5.1
6.0
39.2
39.9
mmol/mol
0.92
310
3633
69
943
0.69
2.22
3.7
4.5
1.0
1.0
kg/l
—
7
139
8
24
3.37
2.19
5.9
1.5
3.1
3.2
nmol/l
—
8
24
13
55
2.40
2.14
2.6
2.4
—
—
—
0
0
110
862
1.36
2.05
3.1
3.0
94.9
93.4
%
0.21
105
834
10
38
2.67
2.02
1.2
1.1
0.1
3.2
u/ml
—
5
12
15
72
2.12
1.88
2.3
2.9
4.3
4.3
e9/l
0.02
15
72
15
73
2.09
1.82
2.9
3.2
59.5
59.9
%
0.03
15
73
6
18
3.36
1.75
3.2
1.9
—
—
—
0
0
11
228
0.47
1.73
2.5
2.4
127.5
127.4
g/l
0.01
11
218
21
118
1.82
1.73
1.4
1.2
38.8
33.9
iu/l
0.28
21
105
14
264
0.52
1.68
2.2
2.3
3.6
4.6
kpa
2.75
14
255
20
337
0.58
1.65
2.4
2.9
—
—
—
0
0
19
323
0.57
1.62
2.4
2.9
6.2
5.9
kpa
1.12
19
313
175
1509
1.25
1.57
10.9
8.3
1.2
1.2
inr
0.26
76
433
56
416
1.39
1.46
1.3
1.2
—
—
—
0
0
101
824
1.29
1.42
4.4
3.7
—
—
—
0
0
408
4229
0.74
1.40
5.2
5.4
2.9
2.8
mmol/l
1.52
332
3863
6
131
0.45
1.30
2.3
2.0
897.2
1791.6
ug/l
—
6
118
8
36
2.24
1.25
3.6
2.2
33.4
32.2
pg
—
8
36
399
4138
0.77
1.24
4.6
4.9
5.8
5.9
mmol/l
0.57
315
3754
7
143
0.48
1.22
1.1
1.3
—
—
—
0
0
68
849
0.77
1.22
2.0
1.7
1197.5
1213.9
nmol/l
0.04
41
627
59
460
1.32
1.16
3.2
3.4
1.0
1.0
mmol/l
0.23
52
407
44
328
1.38
1.16
2.3
1.4
68.8
67.6
g/l
0.45
38
293
380
3957
0.79
1.15
3.9
4.3
1.2
1.3
mmol/l
0.94
304
3562
26
178
1.49
1.08
3.8
6.1
24.4
25.5
mmol/l
0.67
26
178
401
4143
0.78
1.06
4.5
4.8
4.9
4.8
mmol/l
0.79
327
3802
117
1348
0.82
1.03
2.0
2.1
138.0
160.4
u/l
0.36
106
1278
5
22
2.29
1.03
2.4
1.6
—
—
—
0
0
98
828
1.23
1.03
4.1
4.1
—
—
—
0
0
86
1021
0.81
1.02
1.5
1.6
19.4
22.5
nmol/l
1.22
68
863
30
411
0.71
1.01
1.5
1.6
—
—
—
0
0
0
29
0.00
0.98
0.0
2.4
—
—
—
0
0
0
29
0.00
0.98
0.0
1.2
—
—
—
0
0
0
29
0.00
0.98
0.0
1.7
—
10.4
—
0
29
398
4107
0.80
0.95
4.5
4.8
1.6
1.6
mmol/l
0.96
323
3747
49
385
1.30
0.94
1.5
1.8
—
—
—
0
0
195
1774
1.17
0.91
4.9
6.0
8.8
8.4
%
0.71
184
1631
6
29
2.08
0.89
1.0
1.0
—
—
—
0
0
13
79
1.66
0.89
2.6
3.1
23.9
26.1
mmol/l
1.69
13
70
120
1051
1.19
0.88
3.7
3.7
—
—
—
0
0
60
489
1.26
0.88
1.9
1.8
—
—
—
0
0
20
286
0.69
0.87
3.5
4.6
1.2
1.4
mmol/l
0.88
20
276
188
1711
1.16
0.87
4.7
5.8
0.7
0.7
%
0.81
178
1560
11
179
0.61
0.86
2.5
2.5
26.0
25.7
mmol/l
0.16
11
171
198
1810
1.16
0.86
4.8
5.9
27.6
28.9
%
0.84
187
1659
85
990
0.83
0.84
2.2
2.2
2.6
3.0
mg/l
1.04
66
832
155
1713
0.86
0.83
2.5
2.6
110.4
93.6
ug/l
0.79
131
1556
329
3130
1.17
0.83
3.9
4.4
13.6
12.9
mm/h
0.32
284
2875
18
258
0.69
0.81
4.0
5.7
—
—
—
0
0
114
1002
1.18
0.80
2.7
2.9
—
—
—
0
0
9
148
0.60
0.80
4.4
3.8
—
—
—
0
0
61
505
1.24
0.79
22.5
23.9
1.4
1.3
inr
—
6
73
299
2829
1.16
0.79
4.1
4.7
—
—
—
0
0
435
4252
1.30
0.78
15.8
14.2
139.9
139.9
mmol/l
0.00
413
4134
17
116
1.48
0.75
1.6
2.3
—
—
—
0
0
8
134
0.59
0.74
1.0
1.1
—
—
—
0
0
8
135
0.59
0.74
3.1
3.3
—
—
—
0
0
9
55
1.65
0.74
1.4
1.7
—
—
—
0
0
192
1769
1.14
0.73
4.7
5.8
2.7
2.9
%
0.93
178
1619
16
109
1.48
0.72
3.8
3.2
—
—
—
0
0
5
27
1.86
0.68
1.0
1.2
30.4
26.6
g/l
—
5
22
435
4262
1.27
0.67
16.0
14.3
3.9
3.9
mmol/l
0.32
410
4134
7
44
1.60
0.65
1.3
1.0
—
—
—
0
0
8
127
0.62
0.65
1.1
1.1
—
—
—
0
0
193
1791
1.13
0.64
4.7
5.7
56.9
56.6
%
0.15
182
1646
122
1098
1.15
0.64
2.7
3.1
20.1
50.6
e6/l
1.38
85
843
24
313
0.75
0.64
1.2
1.2
92.5
145.1
iu/ml
—
6
130
113
1013
1.15
0.63
2.7
3.0
0.5
0.4
e6/l
0.17
79
777
26
334
0.77
0.63
1.3
1.4
—
—
—
0
0
0
20
0.00
0.60
0.0
1.7
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.3
—
30.6
—
0
21
0
21
0.00
0.60
0.0
2.5
—
9.2
—
0
15
21
276
0.75
0.60
1.0
1.3
—
—
—
0
0
8
53
1.52
0.58
1.7
1.9
88.4
89.6
%
—
8
53
0
23
0.00
0.58
0.0
1.3
—
23.7
—
0
23
0
23
0.00
0.58
0.0
2.7
—
33.0
—
0
16
6
35
1.72
0.58
2.0
1.6
4.3
109.1
u/ml
—
6
35
37
302
1.24
0.57
3.2
3.9
1.5
0.7
%
0.60
13
47
6
36
1.68
0.57
5.3
2.6
—
—
—
0
0
35
285
1.25
0.56
3.3
4.0
0.0
2.1
%
—
10
42
6
37
1.63
0.55
1.2
1.6
7.7
7.0
mmol/l
—
6
28
19
250
0.75
0.55
1.2
1.4
—
—
—
0
0
70
796
0.86
0.54
3.4
4.0
281.1
363.5
ng/l
0.12
53
619
11
74
1.50
0.54
1.8
1.6
—
—
—
0
0
35
287
1.24
0.53
2.9
3.7
1.3
0.4
%
—
10
40
25
313
0.79
0.51
1.1
1.3
—
—
—
0
0
29
235
1.25
0.49
2.4
3.8
—
—
—
0
0
20
256
0.77
0.49
2.2
2.5
—
—
—
0
0
7
109
0.64
0.49
4.3
4.9
—
—
—
0
0
35
291
1.22
0.48
3.4
4.0
0.2
0.0
%
0.93
13
43
91
1005
0.88
0.47
2.9
3.9
—
—
—
0
0
87
960
0.89
0.45
1.6
1.7
464.2
24084227.0
pmol/l
1.06
56
764
7
50
1.41
0.45
1.0
1.8
—
—
—
0
0
406
3979
1.15
0.45
14.9
12.0
18.6
19.8
mg/l
0.39
318
3041
7
51
1.38
0.44
2.0
1.2
—
—
—
0
0
7
51
1.38
0.44
2.0
1.2
—
—
—
0
0
7
51
1.38
0.44
2.0
1.2
—
—
—
0
0
7
51
1.38
0.44
2.0
1.2
—
—
—
0
0
72
802
0.88
0.43
1.3
1.3
23.2
13.2
u/ml
0.30
25
307
390
3979
0.88
0.43
5.4
5.5
1.8
2.2
mu/l
0.68
328
3624
5
32
1.57
0.42
1.2
1.3
—
55.5
u/l
—
0
11
5
32
1.57
0.42
1.0
1.1
—
—
—
0
0
96
877
1.12
0.42
1.5
1.6
1.5
1.0
mg/l
0.27
74
668
43
496
0.85
0.42
1.9
1.9
77.9
140.4
ug/g
1.88
31
387
0
15
0.00
0.41
0.0
1.6
—
—
—
0
0
0
15
0.00
0.41
0.0
1.6
—
25.2
—
0
9
438
4321
1.19
0.41
12.5
9.1
24.8
22.9
u/l
0.51
410
4134
436
4300
1.19
0.41
18.3
14.0
69.5
70.7
umol/l
0.66
436
4300
0
17
0.00
0.40
0.0
15.8
—
754.5
—
0
17
26
214
1.23
0.40
1.2
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
20.4
—
1705.4
—
0
18
32
270
1.20
0.39
1.3
1.3
—
52.2
—
0
12
21
169
1.25
0.39
1.1
1.3
—
0.9
—
0
13
0
19
0.00
0.39
0.0
1.4
—
133.6
—
0
19
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
5
37
1.36
0.37
1.0
1.6
—
—
—
0
0
35
301
1.18
0.36
2.3
1.4
—
—
—
0
0
5
76
0.65
0.36
1.4
1.2
0.5
0.7
nmol/l
—
5
71
5
79
0.63
0.35
1.4
1.2
—
—
—
0
0
24
200
1.21
0.34
1.5
2.1
—
—
—
0
0
6
46
1.31
0.33
1.3
1.0
—
—
—
0
0
6
47
1.28
0.32
1.0
1.1
—
—
—
0
0
11
84
1.32
0.30
7.2
1.3
—
—
—
0
0
51
459
1.12
0.30
1.3
1.4
—
—
—
0
0
7
56
1.25
0.29
1.1
1.2
—
—
—
0
0
56
508
1.12
0.29
2.1
2.3
2.2
2.4
g/l
2.68
45
468
16
195
0.81
0.29
1.5
1.5
—
—
—
0
0
51
460
1.12
0.29
2.1
2.4
22.3
22.0
%
0.04
41
387
30
343
0.87
0.28
1.1
1.1
—
—
—
0
0
12
95
1.27
0.26
1.6
1.8
—
—
—
0
0
115
1087
1.08
0.26
3.8
4.4
0.0
0.0
estimate
0.00
48
343
14
170
0.82
0.25
1.5
1.6
—
—
—
0
0
133
1268
1.07
0.24
3.7
3.7
—
—
—
0
0
447
4435
1.15
0.24
22.5
18.1
91.4
91.2
fl
0.37
431
4357
447
4436
1.15
0.23
22.6
18.2
4.4
4.4
e12/l
1.38
427
4287
447
4436
1.15
0.23
22.6
18.2
6.2
6.5
e9/l
4.24
427
4284
447
4436
1.15
0.23
22.6
18.3
130.8
132.5
g/l
2.14
431
4359
447
4436
1.15
0.23
22.4
18.1
30.2
30.2
pg
0.02
431
4358
447
4436
1.15
0.23
22.6
18.2
255.1
261.4
e9/l
1.55
431
4302
5
39
1.29
0.23
1.4
1.6
271.0
269.1
mosm/kgh2o
—
5
29
5
40
1.25
0.22
1.0
1.1
—
—
—
0
0
38
419
0.90
0.22
4.0
3.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
2.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
12
145
0.82
0.21
1.9
1.7
1.6
1.6
g/l
—
7
130
5
43
1.16
0.21
2.0
2.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.4
—
—
—
0
0
128
1226
1.06
0.20
1.6
1.7
1.3
1.3
mmol/l
0.36
81
1019
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
1105.4
—
0
5
29
323
0.89
0.20
1.2
1.2
—
—
—
0
0
41
378
1.09
0.17
2.2
3.1
63.8
79.6
ng/l
0.98
29
329
16
184
0.86
0.17
1.0
1.2
—
136.5
—
0
10
76
800
0.94
0.16
1.2
1.3
55.8
41.3
iu/ml
0.16
18
268
208
2029
1.05
0.16
3.5
4.1
0.0
0.0
estimate
0.00
48
346
8
73
1.10
0.15
1.1
1.2
—
—
—
0
0
36
334
1.08
0.14
1.8
1.5
—
—
—
0
0
75
785
0.95
0.14
2.4
2.5
6.7
8.8
e6/l
0.31
64
701
21
189
1.12
0.14
2.8
3.3
7.4
7.4
ph
0.44
11
29
92
954
0.96
0.12
2.2
2.1
316.2
5562.2
umol/l
3.66
72
800
10
85
1.18
0.12
1.7
1.2
—
—
—
0
0
128
1246
1.04
0.11
1.8
2.1
50.4
59.6
u/l
2.30
107
1122
61
584
1.05
0.11
1.2
1.3
506.7
670.2
titre
0.37
18
151
232
2284
1.03
0.10
3.8
3.7
6.4
6.7
mmol/l
1.56
223
2120
137
1337
1.03
0.10
3.2
3.6
49.1
129.8
e6/l
2.26
91
925
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
26
279
0.93
0.10
2.8
3.0
—
—
—
0
0
15
135
1.11
0.10
1.1
1.3
—
2.5
—
0
17
352
3490
1.03
0.09
4.6
4.5
15.2
14.9
pmol/l
1.04
290
3180
16
176
0.91
0.09
1.1
1.2
—
—
—
0
0
28
299
0.93
0.09
4.3
2.5
77.0
71.5
e9/l
0.31
22
228
22
237
0.92
0.09
1.1
1.3
—
—
—
0
0
5
61
0.82
0.08
1.2
1.7
—
—
—
0
0
5
63
0.79
0.08
1.4
1.2
—
—
—
0
0
58
559
1.04
0.08
2.3
2.3
12.3
13.1
umol/l
0.36
49
511
208
2052
1.02
0.07
4.7
5.4
0.0
0.0
estimate
0.00
47
337
6
70
0.86
0.07
1.3
1.2
—
—
—
0
0
8
74
1.08
0.07
1.1
1.5
—
—
—
0
0
8
94
0.85
0.06
1.1
1.2
—
1555.0
—
0
6
28
267
1.05
0.05
1.2
1.2
117.5
181.4
u/ml
0.77
23
244
208
2060
1.02
0.05
3.6
4.1
0.0
0.0
estimate
0.80
47
341
152
1501
1.02
0.05
3.0
3.4
—
—
—
0
0
12
130
0.92
0.04
1.0
1.1
—
—
—
0
0
160
1617
0.98
0.04
3.2
3.8
—
—
—
0
0
195
1933
1.02
0.04
4.6
5.6
0.0
0.0
e9/l
1.66
170
1655
74
753
0.98
0.03
1.7
1.3
2.0
2.4
g/l
1.25
35
414
17
179
0.95
0.03
1.6
1.8
—
—
—
0
0
14
132
1.06
0.02
1.1
1.2
—
—
—
0
0
16
167
0.96
0.01
7.8
7.9
—
—
—
0
0
193
1921
1.01
0.01
4.6
5.6
0.6
0.6
e9/l
0.00
169
1647
202
2011
1.01
0.01
4.7
5.8
0.2
0.2
e9/l
0.90
175
1761
23
223
1.03
0.01
4.9
4.3
—
—
—
0
0
16
166
0.96
0.00
1.1
1.2
—
—
—
0
0
37
376
0.98
0.00
1.8
1.8
370.7
360.1
nmol/l
0.11
32
340
63
624
1.01
0.00
1.3
1.2
—
—
—
0
0
127
1276
0.99
0.00
2.5
2.7
1015.8
1124.0
ng/l
0.21
104
1061
197
1964
1.01
0.00
4.7
5.6
1.7
1.9
e9/l
2.67
171
1717
36
355
1.02
0.00
1.2
1.4
—
—
—
0
0
15
153
0.98
0.00
5.1
9.1
—
—
—
0
0
26
257
1.01
0.00
2.1
2.8
4.6
4.5
pmol/l
0.23
18
218
18
179
1.01
0.00
1.4
2.4
0.2
0.2
e6/l
0.04
18
172
39
391
1.00
0.00
4.7
5.3
2.0
1.6
mmol/l
0.45
30
313
72
719
1.00
0.00
2.4
2.7
482.5
502.5
mosm/kgh2o
0.31
59
619
93
933
1.00
0.00
1.2
1.3
0.6
2.3
u/ml
2.07
22
243
157
1575
1.00
0.00
3.5
3.6
29.1
90.9
ng/l
0.71
117
1080
5
53
0.94
0.00
2.2
3.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.9
—
0.8
—
0
8
5
51
0.98
0.00
1.6
2.1
4.0
4.0
mmol/l
—
5
51
0
8
0.00
0.00
0.0
3.6
—
—
—
0
0
0
5
0.00
0.00
0.0
6.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
16.6
—
0
7
5
51
0.98
0.00
1.6
2.1
103.8
105.7
mmol/l
—
5
51
0
5
0.00
0.00
0.0
2.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
92
0.98
0.00
1.2
1.2
—
—
—
0
0
5
55
0.91
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
70.4
—
0
5
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
0
9
0.00
0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
3.0
—
—
—
0
0
8
86
0.93
0.00
2.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
1.6
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
16.4
—
0
6
5
51
0.98
0.00
1.6
2.1
—
—
—
0
0
5
55
0.91
0.00
1.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_BREAST_NOS_EXALLC – Carcinoma in situ of breast, other/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).