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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_SKIN_NOS_EXALLC for full statistics.

Carcinoma in situ of skin, other sites/unspecified

CD2_INSITU_SKIN_NOS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D04.8&, D04.9&
  • Hospital discharge: ICD-9 232[8-9]
  • Cause of death: ICD-10 D04.8&, D04.9&
  • Cause of death: ICD-9 232[8-9]

2 out of 7 registries used, show all original rules.

393

4. Check minimum number of events

None

393

5. Include endpoints

None

393

6. Filter based on genotype QC (FinnGen only)

393

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 393 179 214
Unadjusted period prevalence (%) 0.08 0.06 0.09
Median age at first event (years) 76.42 74.70 77.86

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
324
Matched controls
3237
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D04.9
ICD-10 Finland
Carcinoma in situ: Skin, unspecified
4874.6
231.3
195
*
D04.8
ICD-10 Finland
Carcinoma in situ: Skin of other sites
+∞
165.2
144
*
L57.0
ICD-10 Finland
Actinic keratosis
31.4
152.5
240
270
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
21.0
110.1
183
188
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
32.8
86.7
116
54
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
30.2
78.3
107
52
ZXC50
NOMESCO Finland
Cryotherapy
24.2
76.8
113
70
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
12.8
75.7
154
214
ZXC15
NOMESCO Finland
Use of photodynamic technique
44.2
71.5
88
27
D04.5
ICD-10 Finland
Carcinoma in situ: Skin of trunk
74.1
70.7
79
14
D04.6
ICD-10 Finland
Carcinoma in situ: Skin of upper limb, including shoulder
109.2
58.2
62
7
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
13.2
58.2
110
121
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
11.3
55.7
115
150
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
22.0
54.9
82
49
TQW99
NOMESCO Finland
Other minor procedure on skin
13.8
53.1
97
97
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
18.9
51.9
82
57
D04.7
ICD-10 Finland
Carcinoma in situ: Skin of lower limb, including hip
51.1
49.6
59
14
C44.32
ICD-10 Finland
Spinocellular carcinoma of the skin on another or unspecified part of the face
21.3
44.8
67
39
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
11.0
42.0
85
101
R23.8
ICD-10 Finland
Other and unspecified skin changes
6.3
41.0
131
316
D04.4
ICD-10 Finland
Carcinoma in situ: Skin of scalp and neck
53.3
39.0
46
10
S18
ICPC
Laceration/cut
4.5
35.0
221
1050
D06BB10
ATC
imiquimod; topical
10.3
33.1
68
81
SPAT1153
SPAT
Removal of sutures
4.1
31.2
181
765
8070/3-C44.9
ICD-O-3
Squamous cell carcinoma, NOS, of skin, NOS
20.4
30.7
46
26
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
14.6
29.3
50
40
QAA50
NOMESCO Finland
Cryotherapy of skin of head or neck
22.8
29.1
42
21
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
6.9
28.8
78
143
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
11.6
26.4
50
50
C44.62
ICD-10 Finland
Spinocellular carcinoma of the skin of the upper extremity including the shoulder
54.9
25.7
30
6
QBA25
NOMESCO Finland
Destruction of lesion of skin of trunk
16.0
25.2
41
29
C44.81
ICD-10 Finland
Overall basocellular carcinoma of the skin
34.1
24.2
31
10
C44.52
ICD-10 Finland
Spinocellular carcinoma of the skin on the torso
36.5
23.8
30
9
ZZR00
NOMESCO Finland
Flap of skin
11.6
22.9
43
42
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.4
22.6
43
43
127
Kela drug reimbursment
Transplant complication
26.2
22.6
31
13
ZZA00
NOMESCO Finland
Split skin graft
9.5
22.3
47
57
QXE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in uspecified region
46.9
21.7
26
6
QXA50
NOMESCO Finland
Skin cryotherapy, unspecified location
26.6
19.9
27
11
EP1AE
NOMESCO Finland
Neck ultrasound examination
7.2
19.3
48
76
TQW80
NOMESCO Finland
Local dermatologic skincare
13.5
18.6
32
26
Z94.0
ICD-10 Finland
Kidney transplant status
26.9
18.5
25
10
C44.72
ICD-10 Finland
Spinocellular carcinoma of the skin of the lower extremity including the hip
35.2
18.2
23
7
C44.42
ICD-10 Finland
Spinocellular carcinoma of the skin of the scalp and neck
44.8
17.5
21
5
L82
ICD-10 Finland
Seborrhoeic keratosis
3.4
17.2
99
371
C44.22
ICD-10 Finland
Spinocellular carcinoma of the skin of the outer ear and the outer ear canal
37.3
16.9
21
6
D04.2
ICD-10 Finland
Carcinoma in situ: Skin of ear and external auricular canal
22.4
16.2
23
11
QBA50
NOMESCO Finland
Cryotherapy of skin of trunk
35.4
15.9
20
6
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
167.8
15.6
16
*
C44.71
ICD-10 Finland
Basocellular carcinoma of the skin of the lower extremity including the hip
21.3
15.3
22
11
L04AA01
ATC
[U] ciclosporin; systemic
15.1
14.8
24
17
C44.82
ICD-10 Finland
Overall spinocellular carcinoma of the skin
+∞
14.7
14
*
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
13.4
14.6
25
20
C44.61
ICD-10 Finland
Basocellular carcinoma of the skin of the upper extremity including the shoulder
16.4
14.6
23
15
ZXC20
NOMESCO Finland
Use of chemical agents
8.7
14.4
31
39
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
5.7
14.3
42
83
A98
ICPC
Health maint/preventive medicine
4.5
14.1
304
2502
L04AD01
ATC
ciclosporin; systemic
14.5
13.9
23
17
L04AA06
ATC
mycophenolic acid; systemic
15.6
13.8
22
15
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
35.7
13.6
17
5
QDA50
NOMESCO Finland
Cryotherapy of skin of lower limb
+∞
13.6
13
*
QCA50
NOMESCO Finland
Cryotherapy of skin of upper limb
145.9
13.6
14
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
5.6
13.3
39
77
D07AC01
ATC
betamethasone; topical
2.5
13.1
139
747
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
8.1
13.0
29
39
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.0
12.8
84
338
WXQ41
NOMESCO Finland
Photodynamic therapy of head and neck
33.5
12.7
16
5
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
25.5
12.6
17
7
8070/3-C44.3
ICD-O-3
Squamous cell carcinoma, NOS, of skin of other and unspecified parts of face
10.7
12.2
23
23
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
8.9
12.0
25
30
L57.8
ICD-10 Finland
Other skin changes due to chronic exposure to nonionizing radiation
48.6
12.0
14
*
SPAT1149
SPAT
Suture or treatment of traumatic wound
3.1
11.6
72
277
S77
ICPC
Malignant neoplasm of skin
12.5
11.5
20
17
DAB10
NOMESCO Finland
Partial excision of auricle
36.4
11.4
14
*
8090/3-C44.6
ICD-O-3
Basal cell carcinoma, NOS, of skin of upper limb and shoulder
26.1
11.2
15
6
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
5.9
11.2
31
57
QCA25
NOMESCO Finland
Destruction of lesion of skin of upper limb
14.6
11.1
18
13
XQ848
NOMESCO Finland
Dermatological photography
7.6
11.0
25
35
E0000UV
ATC
NA
2.3
11.0
147
866
C44.21
ICD-10 Finland
Basocellular carcinoma of the skin of the outer ear and the outer ear canal
10.1
10.9
21
22
J01DB01
ATC
cefalexin; oral
2.6
10.9
267
2088
A12AA04
ATC
calcium carbonate; oral
9.0
10.7
22
26
DAB00
NOMESCO Finland
Excision of lesion of auricle
9.0
10.7
22
26
B07.9
ICD-10 Finland
Verruca simplex
7.2
10.6
25
37
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
5.8
10.4
29
54
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
19.6
10.4
15
8
QDE99
NOMESCO Finland
Other excision or repair of lesion of skin of lower limb
24.3
10.3
14
6
C44.30
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face without histology
8.3
10.3
22
28
S29
ICPC
Skin symptom/complaint other
2.6
9.8
80
364
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
9.8
182
1219
N02BE01
ATC
paracetamol; systemic, rectal
2.8
9.6
289
2411
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
9.1
9.4
19
22
ZQZ00
NOMESCO Finland
Treatment of several skin areas
11.1
9.4
17
16
D07AB08
ATC
desonide; topical
3.1
9.2
53
194
L04AX01
ATC
azathioprine; systemic
5.4
9.2
27
54
C44.39
ICD-10 Finland
Malignant tumor of the skin on another or unspecified part of the face other or unspecified histology
16.2
9.1
14
9
8090/3-C44.5
ICD-O-3
Basal cell carcinoma, NOS, of skin of trunk
7.2
9.0
21
31
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.6
8.8
71
318
8070/3-C44.7
ICD-O-3
Squamous cell carcinoma, NOS, of skin of lower limb and hip
51.4
8.7
10
*
C44.59
ICD-10 Finland
Malignant tumor of the skin on the trunk other or unspecified histology
51.4
8.7
10
*
C44.11
ICD-10 Finland
Basocellular carcinoma of the skin of the eyelids including the corner of the eye
12.0
8.7
15
13
XQ845
NOMESCO Finland
Dermatoscopy
8.2
8.5
18
23
C44.02
ICD-10 Finland
Spinocellular carcinoma of the lip skin
+∞
8.4
8
*
A46
ICD-10 Finland
Erysipelas
2.5
8.2
71
330
A11CC03
ATC
alfacalcidol; systemic
5.8
8.1
22
40
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
5.2
8.1
24
49
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
8.1
137
862
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
22.7
8.1
11
5
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
11.2
7.9
14
13
WX110
NOMESCO Finland
Local anesthesy
2.0
7.8
202
1487
8070/3-C44.6
ICD-O-3
Squamous cell carcinoma, NOS, of skin of upper limb and shoulder
46.1
7.7
9
*
-54
ICPC
Repair/fix-suture/cast/prosth device
5.4
7.7
22
43
SPAT1312
SPAT
General health counselling
2.1
7.6
111
654
8070/3-C44.4
ICD-O-3
Squamous cell carcinoma, NOS, of skin of scalp and neck
25.7
7.6
10
*
C44.50
ICD-10 Finland
Malignant tumor of the skin on the torso without histology
25.7
7.6
10
*
QAB10
NOMESCO Finland
Major dressing of wound of skin of head or neck
9.7
7.4
14
15
WXQ99
NOMESCO Finland
Other light therapy
+∞
7.3
7
*
D06BX02
ATC
ingenol mebutate; topical
6.8
7.2
17
26
C02CA01
ATC
prazosin; oral
5.5
7.2
20
38
8070/3-C44.2
ICD-O-3
Squamous cell carcinoma, NOS, of external ear
20.6
7.2
10
5
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.9
6.9
152
1036
137
Kela drug reimbursment
Uraemia requiring dialysis
11.3
6.9
12
11
ZZA50
NOMESCO Finland
Full thickness skin graft
9.6
6.8
13
14
D04.0
ICD-10 Finland
Carcinoma in situ: Skin of lip
40.9
6.8
8
*
PBM10
NOMESCO Finland
Closure of arteriovenous fistula of radial artery
40.9
6.8
8
*
L57.9
ICD-10 Finland
Skin changes due to chronic exposure to nonionizing radiation, unspecified
23.1
6.7
9
*
8070/3-C44.5
ICD-O-3
Squamous cell carcinoma, NOS, of skin of trunk
23.1
6.7
9
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
23.1
6.7
9
*
Z3231
NOMESCO Finland
Registered nurse
2.0
6.7
107
648
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
6.6
137
912
L08.9
ICD-10 Finland
Local infection of skin and subcutaneous tissue, unspecified
5.9
6.5
17
30
C91.1
ICD-10 Finland
Chronic lymphocytic leukaemia of B-cell type
6.8
6.4
15
23
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
8.4
6.4
13
16
Z49.1
ICD-10 Finland
Extracorporeal dialysis
9.5
6.3
12
13
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.6
6.3
44
182
ZXE00
NOMESCO Finland
One hour or less
1.8
6.3
136
913
205
Kela drug reimbursment
Chronic hypertension
1.8
6.3
141
958
L01BB01
ATC
NA
27.2
6.3
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
6.2
56
262
TQW40
NOMESCO Finland
Remowal of suture of skin
3.2
6.1
30
99
ZY010
NOMESCO Finland
Hospital outpatient
5.4
6.1
17
33
PJ2AE
NOMESCO Finland
Lymphnode ultrasound examination
10.3
6.1
11
11
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
6.1
133
895
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.9
6.0
23
62

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_SKIN_NOS – Carcinoma in situ of skin, other sites/unspecified

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).