No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
190 |
4. Check minimum number of eventsNone |
190 |
5. Include endpointsNone |
190 |
6. Filter based on genotype QC (FinnGen only) |
187 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis unius oculi, amblyopia alterius oculi
Similar endpoints
↥List of similar endpoints to
Severe visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1513 | 827 | 679 |
| Only index persons | 1404 | 779 | 625 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 74.74 | 78.44 | 70.27 |
| Only index persons | 74.85 | 78.51 | 70.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 187 | 99 | 88 |
| Unadjusted period prevalence (%) | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | 72.99 | 70.68 | 75.58 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 190
- Matched controls
- 1900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
275.0
190
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
1042.4
74.5
68
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
16.6
64.6
63
55
S01ED51
ATC
timolol, combinations; ophthalmic
11.5
56.1
74
100
S01EC01
ATC
acetazolamide; systemic
17.6
48.4
43
31
Z96.1
ICD-10 Finland
Presence of intraocular lens
8.3
48.4
100
224
S01EA05
ATC
brimonidine; ophthalmic
18.0
43.8
38
26
S01ED01
ATC
timolol; ophthalmic
11.4
36.2
42
46
114
Kela drug reimbursment
Glaucoma
7.5
36.0
66
126
XCK00
NOMESCO Finland
Perimetry
9.4
35.3
49
68
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
10.0
35.3
46
59
WX140
NOMESCO Finland
Parabulbar anesthesy
11.0
33.7
40
45
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
9.0
32.0
45
63
S01EE01
ATC
latanoprost; ophthalmic
8.1
30.2
47
74
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
7.5
28.6
48
82
Z3229
NOMESCO Finland
Other healthcare associate professional
6.3
25.4
51
104
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.1
24.6
71
200
CS494
NOMESCO Finland
Other visual field testing
26.3
24.0
33
15
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
8.0
23.9
36
54
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
35.3
23.6
30
10
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
6.4
22.7
44
86
H16.0
ICD-10 Finland
Corneal ulcer
9.1
21.9
29
37
H33.0
ICD-10 Finland
Retinal detachment with retinal break
10.2
21.7
26
29
H54.0
ICD-10 Finland
Blindness, binocular
+∞
21.2
20
*
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
86.4
21.2
23
*
S01EC04
ATC
brinzolamide; ophthalmic
8.3
21.0
30
42
XCK10
NOMESCO Finland
Photography of fundus of eye
5.3
20.4
50
121
H53.1
ICD-10 Finland
Subjective visual disturbances
33.2
20.2
26
9
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
4.1
19.8
120
564
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.0
19.8
52
133
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.8
17.9
121
599
H47.2
ICD-10 Finland
Optic atrophy
197.7
17.8
18
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.8
17.7
119
586
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.7
17.4
121
606
AA1AD
NOMESCO Finland
CT of head and brain
3.7
17.0
85
344
H54.4
ICD-10 Finland
Blindness, monocular
+∞
16.9
16
*
H3603, E103,
ICD-10 Finland
98.9
16.9
18
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
16.4
70
254
H53.4
ICD-10 Finland
Visual field defects
92.9
15.8
17
*
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.9
15.8
40
98
S01BA01
ATC
dexamethasone; ophthalmic
7.8
15.6
23
33
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
49.4
15.4
18
*
SPAT1216
SPAT
Assessment of functional ability
3.8
15.3
61
210
SPAT1148
SPAT
Treatment of chronic ulcer or burn
4.0
14.8
53
169
CKD15
NOMESCO Finland
Injection of vitreous substitute
39.5
14.7
18
5
S01EE03
ATC
bimatoprost; ophthalmic
18.9
14.7
22
13
SPAT1234
SPAT
Support of social functional capacity
5.6
14.3
30
62
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.6
14.3
61
219
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.7
14.0
58
204
S01BC05
ATC
ketorolac; ophthalmic
5.9
13.9
27
52
CKD40
NOMESCO Finland
Endophotocoagulation of retina
15.4
13.6
22
16
S01EX03, ,
ATC
10.9
13.2
25
26
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
6.4
13.1
23
40
SPAT1254
SPAT
Administration of medicine
3.5
12.9
55
196
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
138.8
12.6
13
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
13.7
12.5
21
17
H04.10
ICD-10 Finland
Dry eye syndrome
4.2
12.2
37
104
CKD20
NOMESCO Finland
Removal of vitreous body substitute
20.6
11.8
17
9
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
24.8
11.8
16
7
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
5.7
11.6
23
45
S01BC03
ATC
diclofenac; ophthalmic
16.4
11.6
18
12
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
4.8
11.5
28
66
A10AC01
ATC
insulin (human); parenteral
4.0
11.4
36
104
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
12.3
11.4
20
18
SPAT1263
SPAT
Sampling
2.8
11.3
104
568
Z94.0
ICD-10 Finland
Kidney transplant status
46.2
11.1
13
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.9
10.9
76
357
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.1
10.9
33
92
A10AB01
ATC
insulin (human); parenteral
5.8
10.9
21
40
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
5.0
10.8
25
56
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
63.7
10.7
12
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
15.4
10.7
17
12
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.6
10.6
21
41
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
116.2
10.5
11
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
116.2
10.5
11
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
116.2
10.5
11
*
Z94.7
ICD-10 Finland
Corneal transplant status
116.2
10.5
11
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
10.5
10
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
34.7
10.5
13
*
L04AA06
ATC
mycophenolic acid; systemic
20.2
10.4
15
8
127
Kela drug reimbursment
Transplant complication
20.2
10.4
15
8
A10AE04
ATC
insulin glargine; parenteral
3.7
10.4
37
116
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
3.0
10.3
58
242
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.5
10.1
41
140
S01EA03
ATC
apraclonidine; ophthalmic
21.4
10.0
14
7
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
27.7
10.0
13
5
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
3.2
9.8
47
178
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
12.3
9.8
17
15
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
58.0
9.8
11
*
H26.4
ICD-10 Finland
After-cataract
3.3
9.7
43
155
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.1
9.7
29
80
H25.8
ICD-10 Finland
Other senile cataract
3.2
9.7
47
179
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
13.3
9.6
16
13
A10AB05
ATC
insulin aspart; parenteral
3.9
9.5
31
91
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
105.0
9.5
10
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
9.4
9
*
A28
ICPC
Limited function/disability NOS
2.8
9.4
62
280
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.5
9.3
36
119
WX100
NOMESCO Finland
Conjunctival surface anesthesia
3.2
9.3
43
159
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.3
9.1
38
132
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
19.8
9.1
13
7
L16
ICPC
Ankle symptom/complaint
3.8
8.9
30
90
L04AD02
ATC
tacrolimus; systemic
52.5
8.8
10
*
S01EC03
ATC
dorzolamide; ophthalmic
10.8
8.7
16
16
A11CC03
ATC
alfacalcidol; systemic
10.8
8.7
16
16
H26.2
ICD-10 Finland
Complicated cataract
21.2
8.6
12
6
L28
ICPC
Limited function/disability (L)
2.8
8.6
54
237
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
9.2
8.5
17
20
Z97.0
ICD-10 Finland
Presence of artificial eye
94.1
8.5
9
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
94.1
8.5
9
*
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
2.8
8.5
55
245
S01EE05
ATC
tafluprost; ophthalmic
7.1
8.4
20
31
R3120
NOMESCO Finland
Training in mobility skills
+∞
8.4
8
*
SPAT1172
SPAT
Guidance concerning hydration
9.6
8.2
16
18
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
12.5
8.2
14
12
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
10.7
8.2
15
15
Z49.1
ICD-10 Finland
Extracorporeal dialysis
18.2
8.2
12
7
S01FA01
ATC
atropine; ophthalmic
35.0
8.2
10
*
SPAT1301
SPAT
No procedures
2.5
8.1
78
419
SPAT1229
SPAT
Assessment of need for aid
3.5
7.9
29
92
C03CA01
ATC
furosemide; systemic
2.4
7.9
97
579
H34.1
ICD-10 Finland
Central retinal artery occlusion
46.9
7.8
9
*
H33.4
ICD-10 Finland
Traction detachment of retina
46.9
7.8
9
*
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
3.0
7.7
39
151
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
19.3
7.7
11
6
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
7.7
85
484
F28
ICPC
Limited function/disability (F)
26.2
7.7
10
*
F05
ICPC
Visual disturbance other
8.2
7.6
16
21
H40.0
ICD-10 Finland
Glaucoma suspect
3.7
7.5
25
74
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.8
7.5
24
69
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
14.1
7.5
12
9
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
7.5
46
198
H27.0
ICD-10 Finland
Aphakia
83.2
7.5
8
*
A10AB04
ATC
insulin lispro; parenteral
6.7
7.4
18
29
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
3.2
7.4
32
113
ZXD05
NOMESCO Finland
Urgent procedure
2.4
7.4
74
402
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
6.5
7.3
18
30
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
8.5
7.3
15
19
E10.1
ICD-10 Finland
Type 1 diabetes mellitus, With ketoacidosis
31.3
7.2
9
*
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
7.1
36
139
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.3
7.1
79
447
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.7
7.1
17
39
SPAT1256
SPAT
Intramuscular and subcutaneous injection
2.3
7.0
89
533
TK800
NOMESCO Finland
Hemodialysis
8.8
7.0
14
17
A10AA02, ,
ATC
4.2
6.9
19
49
A10AE05
ATC
insulin detemir; parenteral
4.0
6.8
20
54
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
41.6
6.8
8
*
CHD99
NOMESCO Finland
Other filtering operation
41.6
6.8
8
*
H16.2
ICD-10 Finland
Keratoconjunctivitis
23.5
6.7
9
*
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
23.5
6.7
9
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.9
6.7
34
132
XCD10
NOMESCO Finland
Electrophysiological examination of eye
6.6
6.6
16
26
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.4
6.6
58
296
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.0
6.5
19
51
H44.5
ICD-10 Finland
Degenerated conditions of globe
72.2
6.5
7
*
H18.1
ICD-10 Finland
Bullous keratopathy
72.2
6.5
7
*
H04AA01
ATC
glucagon; nasal, parenteral
8.6
6.4
13
16
S01EB01
ATC
pilocarpine; ophthalmic
11.6
6.4
11
10
H3603, E113,
ICD-10 Finland
11.6
6.4
11
10
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
5.4
6.4
18
36
NF1AA
NOMESCO Finland
Hip X-ray examination
3.2
6.4
27
94
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
3.4
6.3
24
78
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.7
6.3
37
155
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
+∞
6.3
6
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
27.7
6.3
8
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
27.7
6.3
8
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
27.7
6.3
8
*
SPAT1104
SPAT
Monitoring of emergency patient
4.0
6.2
18
48
H02AB09
ATC
hydrocortisone; systemic
8.1
6.2
13
17
H02AB04
ATC
methylprednisolone; systemic
2.6
6.2
39
169
A10AA01, ,
ATC
5.9
6.1
16
29
CKC12
NOMESCO Finland
Photocoagulation of retina
5.4
6.0
17
34
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
57
161
4.63
19.17
5.9
4.6
32.36
32.56
%
0.04
36
99
58
173
4.39
18.09
12.2
8.8
—
—
—
0
0
30
56
6.17
16.00
2.3
1.9
—
—
—
0
0
31
61
5.88
15.66
2.6
2.1
—
—
—
0
0
113
600
3.18
13.71
5.2
4.2
43.69
44.43
ng/l
0.02
96
444
123
693
3.20
13.31
25.0
19.1
1.29
1.37
inr
0.26
23
192
89
424
3.07
12.87
2.6
2.1
190.95
233.28
u/l
0.19
78
393
74
319
3.16
12.72
3.2
2.6
—
—
—
0
0
35
97
4.20
11.71
8.0
3.3
0.30
1.47
mmol/l
0.74
25
73
39
119
3.87
11.43
22.1
7.5
15.17
10.51
mmol/l
1.62
34
108
145
943
3.27
11.42
7.2
5.0
23.00
2645.04
e6/l
—
5
28
111
632
2.82
11.07
14.2
6.7
1.21
1.21
mmol/l
0.28
93
568
49
178
3.36
11.02
18.5
6.2
1.11
1.07
mmol/l
0.30
38
158
131
825
2.89
10.56
10.3
5.3
7.43
6.82
mmol/l
1.81
125
766
60
258
2.94
10.04
2.3
1.9
—
—
—
0
0
76
374
2.72
9.82
3.0
2.2
4.11
3.22
mg/l
1.57
59
332
114
686
2.65
9.76
18.4
7.8
1.22
1.21
mmol/l
0.28
91
580
69
326
2.75
9.62
2.3
1.8
1381.53
1150.95
nmol/l
1.04
48
253
40
142
3.30
9.23
2.6
2.9
5.16
6.98
ug/l
0.40
25
128
98
566
2.51
8.89
2.6
2.2
90.38
92.76
pmol/l
0.14
49
295
83
446
2.53
8.76
4.5
2.6
55.00
64.51
u/l
0.42
74
416
13
11
12.58
7.70
1.0
1.4
—
—
—
0
0
29
94
3.46
7.67
1.3
1.3
—
—
—
0
0
31
105
3.33
7.66
11.0
3.6
173.62
78.45
ng/l
2.36
26
93
82
464
2.35
7.47
3.9
3.4
2304.52
1783.10
ng/l
0.29
64
397
100
621
2.29
7.26
3.9
2.9
—
—
—
0
0
15
19
8.47
7.26
11.9
10.3
793.67
172.00
iu/ml
—
6
7
113
756
2.22
6.63
6.5
6.1
9.18
11.46
umol/l
3.11
102
706
100
643
2.17
6.42
11.2
4.2
33.95
34.97
g/l
0.95
88
592
135
987
2.27
6.15
4.9
3.9
14.97
14.84
pmol/l
0.20
108
880
26
91
3.15
6.06
2.0
1.7
—
—
—
0
0
61
341
2.16
5.43
1.9
1.8
421.00
440.21
pmol/l
0.16
50
292
12
18
7.04
5.34
1.9
1.4
—
—
—
0
0
32
135
2.65
5.33
9.5
4.1
6.00
5.72
kpa
1.04
32
130
64
368
2.11
5.28
1.7
1.6
20.72
20.52
nmol/l
0.03
49
313
134
1008
2.12
5.24
6.3
4.1
17.45
13.34
mm/h
1.95
117
918
46
232
2.30
5.23
6.9
2.4
11.88
12.55
umol/l
0.24
40
209
67
394
2.08
5.19
6.6
4.3
0.00
0.00
estimate
-0.00
15
112
44
219
2.31
5.16
4.0
3.9
0.81
0.82
mmol/l
0.16
37
201
71
428
2.05
5.14
6.0
3.7
17.70
9.09
mg/mmol
0.46
51
271
81
513
2.01
5.11
6.3
3.4
—
—
—
0
0
87
567
1.99
5.04
5.8
2.8
170.52
133.07
ug/l
0.65
77
521
42
207
2.32
5.03
7.4
2.5
22.33
22.00
%
0.04
34
173
154
1233
2.31
4.99
5.8
4.6
1.98
1.96
mu/l
0.06
126
1105
86
562
1.97
4.91
3.3
2.3
73.65
75.21
nmol/l
0.21
71
496
28
116
2.66
4.82
7.8
3.2
5.71
4.26
kpa
1.32
28
111
43
219
2.25
4.75
7.2
2.4
2.19
2.30
g/l
0.55
37
195
108
771
1.93
4.68
10.8
9.6
4.46
4.32
e9/l
0.25
94
679
164
1363
2.49
4.64
29.5
16.1
23.86
25.08
mg/l
0.17
143
1092
167
1402
2.58
4.57
38.6
18.9
139.41
139.60
mmol/l
0.34
158
1357
11
19
6.07
4.51
1.6
1.5
—
—
—
0
0
167
1406
2.55
4.47
38.8
18.9
4.00
4.00
mmol/l
0.02
158
1363
11
20
5.77
4.36
1.6
1.5
—
—
—
0
0
11
20
5.77
4.36
1.6
1.5
—
—
—
0
0
11
20
5.77
4.36
1.6
1.5
—
—
—
0
0
11
20
5.77
4.36
1.6
1.5
—
—
—
0
0
11
20
5.77
4.36
1.6
1.5
—
—
—
0
0
13
29
4.73
4.33
1.5
1.4
—
—
—
0
0
7
6
12.04
4.31
1.0
1.0
—
—
—
0
0
16
52
3.27
4.19
1.8
2.5
—
—
—
0
0
10
17
6.14
4.19
8.8
2.5
—
—
—
0
0
28
126
2.43
4.07
2.3
2.5
0.22
0.21
g/l
0.12
28
118
16
53
3.20
4.07
1.1
1.3
—
—
—
0
0
23
94
2.65
4.06
2.3
3.2
56.05
64.14
ml/min/173m2
—
8
37
156
1293
2.15
4.06
7.2
4.8
6.68
6.05
mmol/l
2.58
126
1162
10
18
5.80
4.03
1.2
1.9
—
—
—
0
0
10
18
5.80
4.03
1.2
1.9
—
—
—
0
0
10
18
5.80
4.03
1.4
1.3
—
—
—
0
0
10
18
5.80
4.03
1.2
1.9
—
—
—
0
0
136
1076
1.93
4.02
12.5
7.2
85.17
80.02
u/l
0.44
126
987
12
28
4.50
3.89
1.4
1.7
—
—
—
0
0
12
28
4.50
3.89
1.4
1.7
—
—
—
0
0
74
490
1.84
3.86
4.8
3.2
2.34
2.36
mmol/l
0.72
57
428
93
671
1.76
3.57
6.8
5.6
0.00
0.00
estimate
-0.00
15
120
94
682
1.75
3.52
5.9
4.2
0.00
0.00
estimate
-0.00
14
116
93
675
1.74
3.46
6.0
4.2
0.00
0.00
estimate
-0.00
15
133
151
1268
1.93
3.34
10.6
6.0
44.91
40.55
mmol/mol
3.11
124
1171
6
7
8.80
3.28
1.2
1.6
—
—
—
0
0
6
7
8.80
3.28
1.2
1.6
—
—
—
0
0
14
49
3.00
3.27
1.5
1.9
—
—
—
0
0
24
113
2.29
3.16
2.7
1.6
—
—
—
0
0
109
844
1.68
3.08
5.1
3.0
53.75
48.68
u/l
0.27
102
773
6
8
7.70
3.07
1.0
1.1
—
—
—
0
0
6
8
7.70
3.07
1.2
2.0
—
—
—
0
0
6
8
7.70
3.07
1.0
1.3
—
—
—
0
0
6
8
7.70
3.07
1.2
2.0
—
—
—
0
0
77
544
1.70
3.07
6.2
4.5
—
—
—
0
0
169
1490
2.21
3.05
44.5
23.3
246.13
244.32
e9/l
0.09
160
1452
11
31
3.70
3.04
1.7
1.4
—
—
—
0
0
169
1491
2.21
3.03
44.3
23.4
38.36
39.29
%
1.38
152
1399
169
1491
2.21
3.03
44.4
23.3
4.22
4.42
e12/l
4.02
159
1445
169
1492
2.20
3.01
44.6
23.5
126.28
133.00
g/l
5.24
160
1462
8
17
4.86
2.95
1.1
1.9
—
—
—
0
0
6
9
6.84
2.89
1.2
1.7
—
—
—
0
0
6
9
6.84
2.89
1.2
1.7
—
—
—
0
0
6
9
6.84
2.89
1.3
1.9
—
—
—
0
0
33
183
1.97
2.88
6.7
9.2
0.46
1.59
mmol/l
0.77
26
143
9
23
4.05
2.81
1.6
1.2
—
—
—
0
0
32
179
1.95
2.73
6.9
9.3
11.57
11.56
kpa
0.00
27
166
6
10
6.15
2.72
1.2
1.9
—
—
—
0
0
6
10
6.15
2.72
1.2
1.9
—
—
—
0
0
6
10
6.15
2.72
1.0
1.1
—
—
—
0
0
6
10
6.15
2.72
1.0
1.1
—
—
—
0
0
8
19
4.35
2.71
1.3
1.8
—
—
—
0
0
163
1438
1.94
2.64
17.3
10.3
23.93
24.67
u/l
0.25
147
1377
12
42
2.98
2.60
1.4
1.6
—
—
—
0
0
149
1296
1.69
2.32
6.0
4.4
4.29
4.50
mmol/l
1.50
125
1177
5
9
5.67
2.22
1.0
1.3
—
—
—
0
0
5
9
5.67
2.22
1.4
1.0
—
—
—
0
0
16
74
2.27
2.22
6.3
2.8
0.73
0.70
%
0.14
16
74
11
42
2.72
2.18
1.6
1.6
—
—
—
0
0
16
75
2.24
2.15
6.3
2.8
1.25
1.19
%
0.12
16
75
147
1288
1.62
2.07
6.3
4.4
1.36
1.46
mmol/l
2.07
123
1159
43
286
1.65
2.07
1.7
1.7
1.30
1.44
mg/l
0.17
34
228
143
1246
1.60
2.05
20.6
14.8
67.86
76.16
ml/min/173m2
3.01
114
1015
5
11
4.64
1.95
1.4
1.0
17432.80
266.27
pmol/l
—
5
11
5
11
4.64
1.95
1.2
1.3
—
—
—
0
0
52
368
1.57
1.94
5.6
2.8
391.07
8133.33
umol/l
1.96
41
294
9
34
2.73
1.89
1.0
1.6
—
—
—
0
0
5
12
4.25
1.83
1.0
1.1
—
—
—
0
0
9
36
2.57
1.76
2.0
1.4
—
0.04
—
0
10
6
18
3.41
1.76
1.7
1.6
—
—
—
0
0
6
18
3.41
1.76
1.7
1.6
—
—
—
0
0
33
214
1.66
1.75
2.8
1.6
28.14
29.62
s
1.06
33
206
8
32
2.56
1.61
1.3
1.3
—
—
—
0
0
8
32
2.56
1.61
1.1
1.3
—
—
—
0
0
24
151
1.67
1.43
2.6
3.5
—
—
—
0
0
139
1242
1.44
1.43
5.7
4.0
1.52
1.25
mmol/l
3.69
116
1110
10
46
2.24
1.42
3.6
2.1
24.92
24.74
mmol/l
—
10
46
19
113
1.76
1.38
3.2
2.7
62.26
65.51
g/l
0.75
13
100
60
468
1.41
1.36
6.4
5.0
1.91
2.39
ug/l
0.59
50
408
0
39
0.00
1.35
0.0
1.5
—
—
—
0
0
147
1335
1.45
1.31
6.4
4.9
2.42
2.61
mmol/l
1.71
124
1201
8
34
2.41
1.31
1.0
1.6
—
—
—
0
0
10
48
2.14
1.30
3.0
4.8
23.74
31.90
mg/l
—
5
29
5
19
2.67
1.22
1.0
1.2
—
—
—
0
0
50
386
1.40
1.19
3.6
3.1
0.83
0.36
e6/l
0.42
44
298
7
35
2.04
1.01
1.4
1.5
110.29
89.28
pmol/l
—
7
35
31
226
1.44
1.01
3.4
2.7
1.56
1.21
e6/l
0.23
22
138
36
272
1.40
0.97
1.3
1.3
1.10
2.40
u/ml
—
9
64
7
37
1.93
0.95
1.4
1.3
—
—
—
0
0
6
28
2.18
0.92
1.7
1.6
—
—
—
0
0
6
29
2.10
0.90
1.0
1.2
22.13
18.49
u/l
—
6
23
25
180
1.45
0.87
1.8
1.7
—
—
—
0
0
25
181
1.44
0.85
2.0
1.8
—
—
—
0
0
12
74
1.66
0.80
5.5
6.6
25.59
24.63
mmol/l
0.50
12
74
0
26
0.00
0.79
0.0
1.6
—
—
—
0
0
5
24
2.11
0.75
1.6
1.7
—
—
—
0
0
5
25
2.03
0.73
1.0
1.6
—
—
—
0
0
5
30
1.68
0.62
1.6
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.5
—
—
—
0
0
43
362
1.24
0.56
6.3
4.5
21.53
22.00
%
0.07
29
180
5
31
1.63
0.43
1.0
1.1
—
—
—
0
0
10
70
1.45
0.42
1.4
3.0
4.47
4.36
pmol/l
—
10
60
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.41
0.0
2.5
—
219.70
—
0
17
0
17
0.00
0.41
0.0
3.1
—
—
—
0
0
9
66
1.38
0.39
1.4
1.4
—
—
—
0
0
24
199
1.24
0.37
1.5
1.2
19.98
8.32
u/ml
—
6
75
38
331
1.19
0.37
1.9
1.6
1.57
1.31
mmol/l
1.29
31
277
6
45
1.34
0.34
1.5
1.2
—
—
—
0
0
6
46
1.31
0.33
1.5
1.2
—
—
—
0
0
23
193
1.22
0.32
1.6
1.5
—
—
—
0
0
24
208
1.18
0.25
1.3
1.2
15.09
33.53
iu/ml
—
7
66
81
767
1.10
0.22
3.0
3.0
—
—
—
0
0
30
268
1.14
0.22
3.8
3.8
185.22
97.76
ng/l
0.31
23
215
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
483.83
—
0
6
0
12
0.00
0.21
0.0
1.0
—
44.17
—
0
6
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.6
—
—
—
0
0
14
164
0.84
0.19
1.2
1.3
—
—
—
0
0
24
215
1.13
0.17
3.3
3.0
2.68
2.19
e6/l
0.09
13
128
8
98
0.81
0.14
1.1
2.2
—
—
—
0
0
9
110
0.81
0.13
1.1
2.4
—
—
—
0
0
5
47
1.07
0.09
1.0
1.9
—
—
—
0
0
25
257
0.97
0.01
3.8
2.9
0.75
0.87
ug/l
0.28
18
170
29
283
1.03
0.01
2.8
2.9
2.44
2.47
mmol/l
0.58
24
236
13
132
0.98
0.00
1.5
1.5
1.74
1.56
%
—
8
115
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
5
54
0.92
-0.00
1.8
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
15.38
—
0
9
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
61
0.98
-0.00
1.0
1.9
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_SEVVISIMPBINOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.435 [1.09, 1.88] | 0.009 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 721 females with H7_SEVVISIMPBINOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.576 [1.15, 2.15] | 0.004 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 257 out of 605 males with H7_SEVVISIMPBINOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_SEVVISIMPBINOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.294% |
| 5 | 0.592% | 1.968% |
| 10 | 1.64% | 4.809% |
| 15 | 3.245% | 9.312% |
| 20 | 5.846% | 15.604% |
Relationships between endpoints
↥Index endpoint: H7_SEVVISIMPBINOC – Severe visual impairment, binocular
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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