No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
174 |
4. Check minimum number of eventsNone |
174 |
5. Include endpointsNone |
174 |
6. Filter based on genotype QC (FinnGen only) |
174 |
Control definitions (FinnGen only)
- Control exclude
- H7_VISUALDISTBLIND
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H54
- Name in latin
- Amaurosis unius oculi, amblyopia alterius oculi
Similar endpoints
↥List of similar endpoints to
Severe visual impairment, binocular
based on the number of shared cases.
Similar with more cases:
- Visual impairment including blindness (binocular or monocular)
- Visual disturbances and blindness
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 1513 | 827 | 679 |
| Only index persons | 1404 | 779 | 625 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.02 | 0.02 | 0.02 |
| Only index persons | 0.03 | 0.03 | 0.02 |
| Median age at first event (years) | |||
| Whole population | 74.74 | 78.44 | 70.27 |
| Only index persons | 74.85 | 78.51 | 70.27 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 174 | 91 | 83 |
| Unadjusted period prevalence (%) | 0.03 | 0.03 | 0.04 |
| Median age at first event (years) | 72.07 | 70.61 | 73.68 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 149
- Matched controls
- 1489
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
215.4
149
*
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
+∞
61.9
55
*
S01ED51
ATC
timolol, combinations; ophthalmic
11.8
27.2
54
68
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
14.8
23.2
40
36
Z96.1
ICD-10 Finland
Presence of intraocular lens
6.9
23.0
69
165
XCK00
NOMESCO Finland
Perimetry
11.8
19.9
38
42
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
80.7
19.3
21
*
H53.1
ICD-10 Finland
Subjective visual disturbances
216.1
19.0
19
*
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
9.7
18.8
40
54
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.2
18.3
57
136
H54.0
ICD-10 Finland
Blindness, binocular
+∞
17.0
16
*
CS494
NOMESCO Finland
Other visual field testing
45.7
16.8
20
5
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
16.2
16.8
27
20
S01EC01
ATC
acetazolamide; systemic
14.7
16.7
28
23
114
Kela drug reimbursment
Glaucoma
6.3
16.1
47
101
H33.0
ICD-10 Finland
Retinal detachment with retinal break
21.2
15.2
22
12
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
4.1
15.0
91
412
H53.4
ICD-10 Finland
Visual field defects
+∞
14.8
14
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
4.1
14.8
92
423
WX140
NOMESCO Finland
Parabulbar anesthesy
10.9
14.5
28
31
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
4.0
14.5
91
420
S01EE01
ATC
latanoprost; ophthalmic
7.6
14.3
35
58
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
8.4
14.1
32
47
CKW99
NOMESCO Finland
Other operation on choroid, vitreous body and retina
59.3
14.1
16
*
H3603, E103
ICD-10 Finland
NA
82.6
13.8
15
*
AA1AD
NOMESCO Finland
CT of head and brain
4.3
13.8
63
217
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.8
13.8
42
94
H47.2
ICD-10 Finland
Optic atrophy
+∞
13.8
13
*
H35.31
ICD-10 Finland
Senile macular degeneration (atrophic)(exudative)
7.9
12.9
30
46
CKD15
NOMESCO Finland
Injection of vitreous substitute
141.4
12.6
13
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.3
12.6
35
69
CKD40
NOMESCO Finland
Endophotocoagulation of retina
41.3
12.5
15
*
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
3.6
12.3
86
413
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
4.4
12.2
50
152
H16.0
ICD-10 Finland
Corneal ulcer
10.2
11.8
23
26
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
129.6
11.6
12
*
127
Kela drug reimbursment
Transplant complication
38.3
11.5
14
*
S01ED01
ATC
timolol; ophthalmic
7.1
11.3
28
47
S01EE03
ATC
bimatoprost; ophthalmic
14.4
11.0
18
14
L04AA06
ATC
mycophenolic acid; systemic
30.6
10.9
14
5
A10AA01
ATC
NA
30.6
10.9
14
5
CKD20
NOMESCO Finland
Removal of vitreous body substitute
64.8
10.8
12
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
118.0
10.6
11
*
H54.4
ICD-10 Finland
Blindness, monocular
+∞
10.5
10
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
20.6
10.5
15
8
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
43.2
10.1
12
*
S01EC54
ATC
brinzolamide, combinations; ophthalmic
43.2
10.1
12
*
H43.1
ICD-10 Finland
Vitreous haemorrhage
11.9
10.1
18
17
H04.10
ICD-10 Finland
Dry eye syndrome
6.5
9.9
26
47
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
58.9
9.8
11
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.7
9.8
50
180
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
15.0
9.4
15
11
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
12.6
9.3
16
14
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
39.3
9.1
11
*
H36.03
ICD-10 Finland
Proliferative diabetic retinopathy
20.2
9.1
13
7
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
6.6
9.1
23
40
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
5.2
9.0
28
63
XCD10
NOMESCO Finland
Electrophysiological examination of eye
15.3
8.9
14
10
SPAT1254
SPAT
Administration of medicine
3.7
8.9
42
142
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
9.9
8.8
17
19
A11CC03
ATC
alfacalcidol; systemic
12.7
8.8
15
13
L04AD01
ATC
ciclosporin; systemic
53.2
8.8
10
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
53.2
8.8
10
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
3.1
8.7
58
253
Z94.0
ICD-10 Finland
Kidney transplant status
29.5
8.6
11
*
S01EX03
ATC
NA
7.9
8.6
19
27
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
95.2
8.5
9
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.7
8.4
40
135
Z97.0
ICD-10 Finland
Presence of artificial eye
+∞
8.4
8
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
+∞
8.4
8
*
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
15.7
8.4
13
9
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
4.9
8.3
27
64
S01BC05
ATC
ketorolac; ophthalmic
6.1
8.2
22
41
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
7.3
8.2
19
29
Z49.1
ICD-10 Finland
Extracorporeal dialysis
23.6
8.1
11
5
SPAT1263
SPAT
Sampling
2.8
8.1
76
407
S01BC03
ATC
diclofenac; ophthalmic
9.3
8.0
16
19
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.4
7.9
18
27
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
47.5
7.8
9
*
TK800
NOMESCO Finland
Hemodialysis
12.8
7.7
13
11
A10AA02
ATC
NA
7.8
7.7
17
24
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
4.6
7.7
27
69
S01FA01
ATC
atropine; ophthalmic
26.6
7.7
10
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
5.2
7.6
23
50
S01EC04
ATC
brinzolamide; ophthalmic
5.8
7.6
21
41
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.3
7.6
41
152
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
14.4
7.5
12
9
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
84.1
7.5
8
*
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
84.1
7.5
8
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
84.1
7.5
8
*
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
7.2
7.4
17
26
H33.4
ICD-10 Finland
Traction detachment of retina
+∞
7.3
7
*
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
31.7
7.2
9
*
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
31.7
7.2
9
*
Z94.7
ICD-10 Finland
Corneal transplant status
31.7
7.2
9
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
4.7
7.2
24
58
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
12.9
7.2
12
10
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
10.8
7.2
13
13
T89
ICPC
Diabetes insulin dependent
10.8
7.2
13
13
SPAT1216
SPAT
Assessment of functional ability
3.3
7.2
39
145
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
4.1
7.0
27
76
F05
ICPC
Visual disturbance other
10.0
6.9
13
14
S01EE05
ATC
tafluprost; ophthalmic
7.8
6.9
15
21
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
17.7
6.8
10
6
E10.4
ICD-10 Finland
Type 1 diabetes mellitus, With neurological complications
42.0
6.8
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
6.7
30
96
CJB10
NOMESCO Finland
Laser discission of secondary cataract
3.9
6.7
27
79
SPAT1234
SPAT
Support of social functional capacity
4.9
6.7
21
48
A10AE04
ATC
insulin glargine; parenteral
4.0
6.6
26
75
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
6.5
35
127
H26.02
ICD-10 Finland
Presenil cataract
15.2
6.5
10
7
H26.2
ICD-10 Finland
Complicated cataract
15.2
6.5
10
7
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
72.8
6.5
7
*
R3120
NOMESCO Finland
Training in mobility skills
72.8
6.5
7
*
Z49.0
ICD-10 Finland
Preparatory care for dialysis
72.8
6.5
7
*
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
5.0
6.5
20
45
G40.9
ICD-10 Finland
Epilepsy, unspecified
9.9
6.4
12
13
S01EA03
ATC
apraclonidine; ophthalmic
11.8
6.4
11
10
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
6.4
66
360
H26.4
ICD-10 Finland
After-cataract
3.7
6.4
28
88
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
7.6
6.4
14
20
L04AA01
ATC
[U] ciclosporin; systemic
19.0
6.3
9
5
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
+∞
6.3
6
*
H3601, E103
ICD-10 Finland
NA
+∞
6.3
6
*
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
9.2
6.2
12
14
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
13.3
6.2
10
8
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
10.7
6.1
11
11
A28
ICPC
Limited function/disability NOS
2.8
6.1
43
189
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.6
6.1
27
86
C03CA01
ATC
furosemide; systemic
2.4
6.0
73
430
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
54
151
4.74
18.50
12.8
9.2
—
—
—
0
0
50
144
4.47
16.33
5.6
4.5
32.4
32.6
%
0.03
31
88
26
51
5.82
13.15
2.3
1.9
—
—
—
0
0
27
55
5.63
13.12
2.6
2.1
—
—
—
0
0
102
542
3.13
12.31
5.3
4.2
46.4
47.1
ng/l
0.02
86
395
82
392
3.06
11.83
2.7
2.0
194.7
234.1
u/l
0.16
72
363
65
275
3.18
11.55
3.1
2.6
—
—
—
0
0
36
115
3.69
9.87
22.0
7.2
15.4
10.5
mmol/l
1.56
31
104
44
162
3.30
9.68
18.7
6.3
1.1
1.1
mmol/l
0.30
34
143
38
128
3.52
9.61
2.6
2.6
5.2
7.4
ug/l
0.45
24
114
30
88
3.91
9.26
8.2
3.1
0.1
1.7
mmol/l
0.96
22
64
13
18
7.72
8.97
13.6
10.6
793.7
159.0
iu/ml
—
6
6
98
574
2.62
8.88
14.3
6.8
1.2
1.2
mmol/l
0.13
81
514
53
232
2.85
8.54
2.1
1.9
—
—
—
0
0
102
621
2.55
8.35
18.3
7.7
1.2
1.2
mmol/l
0.17
80
523
88
503
2.52
8.21
2.5
2.2
90.0
94.2
pmol/l
0.25
44
260
115
751
2.57
7.96
11.0
5.4
7.5
6.8
mmol/l
1.84
110
696
11
16
7.27
7.24
2.0
1.4
—
—
—
0
0
65
344
2.42
6.93
2.9
2.2
4.3
3.2
mg/l
1.71
50
308
73
411
2.34
6.73
3.9
3.5
2384.1
1867.8
ng/l
0.25
58
350
59
303
2.43
6.69
2.3
1.9
1440.6
1161.5
nmol/l
1.16
40
235
71
406
2.26
6.21
4.9
2.7
53.7
53.8
u/l
0.01
64
376
10
8
13.16
6.16
1.0
1.5
—
—
—
0
0
90
581
2.14
5.69
11.3
4.3
33.8
35.0
g/l
1.03
79
538
86
553
2.10
5.42
5.8
4.3
—
—
—
0
0
10
18
5.83
5.39
1.7
1.6
—
—
—
0
0
100
683
2.09
5.33
6.4
6.2
9.4
11.5
umol/l
2.41
89
640
42
206
2.37
5.14
6.3
2.5
11.9
12.3
umol/l
0.14
37
183
12
27
4.70
5.12
1.5
1.4
—
—
—
0
0
10
19
5.52
5.10
1.7
1.5
—
—
—
0
0
10
19
5.52
5.10
1.7
1.5
—
—
—
0
0
10
19
5.52
5.10
1.7
1.5
—
—
—
0
0
10
19
5.52
5.10
1.7
1.5
—
—
—
0
0
10
19
5.52
5.10
1.7
1.5
—
—
—
0
0
120
888
2.13
5.04
4.7
3.9
15.2
14.8
pmol/l
0.61
96
793
74
465
2.03
4.83
6.6
3.3
—
—
—
0
0
61
357
2.09
4.83
7.0
4.3
0.0
0.0
estimate
0.00
15
100
22
80
3.00
4.82
2.3
3.6
56.1
63.7
ml/min/173m2
—
8
35
23
86
2.93
4.81
1.3
1.3
—
—
—
0
0
38
186
2.33
4.65
6.8
2.5
23.2
21.5
%
0.25
31
154
39
196
2.28
4.48
6.7
2.4
2.2
2.3
g/l
0.48
34
174
16
51
3.35
4.33
1.1
1.3
—
—
—
0
0
138
1110
2.18
4.22
5.6
4.6
1.9
2.0
mu/l
0.03
113
993
9
13
7.23
4.22
1.1
1.9
—
—
—
0
0
9
13
7.23
4.22
1.1
1.9
—
—
—
0
0
9
13
7.23
4.22
1.1
1.9
—
—
—
0
0
151
1265
2.47
4.10
38.4
19.0
139.3
139.6
mmol/l
0.47
142
1221
97
698
1.88
4.03
10.2
9.5
4.5
4.3
e9/l
0.21
83
617
148
1232
2.35
4.03
28.9
16.2
25.0
25.1
mg/l
0.02
128
985
151
1269
2.44
4.00
38.5
18.9
4.0
4.0
mmol/l
0.12
142
1227
21
83
2.74
3.97
1.7
1.8
—
—
—
0
0
9
15
6.26
3.87
9.2
2.5
—
—
—
0
0
118
914
1.90
3.80
5.9
4.1
17.7
13.5
mm/h
1.69
101
834
24
105
2.49
3.72
2.7
1.6
—
—
—
0
0
75
512
1.82
3.57
3.2
2.3
72.6
75.2
nmol/l
0.37
61
454
6
6
10.29
3.52
1.0
1.0
—
—
—
0
0
6
6
10.29
3.52
1.0
1.0
—
—
—
0
0
6
6
10.29
3.52
1.2
1.8
—
—
—
0
0
6
6
10.29
3.52
1.2
1.8
—
—
—
0
0
51
311
1.91
3.45
1.9
1.8
450.0
442.3
pmol/l
0.05
43
268
140
1167
2.02
3.39
6.9
4.7
6.7
6.0
mmol/l
2.31
111
1052
37
203
2.04
3.37
4.5
3.9
0.8
0.8
mmol/l
0.20
32
184
6
7
8.82
3.29
1.2
1.7
—
—
—
0
0
6
7
8.82
3.29
1.2
1.6
—
—
—
0
0
6
7
8.82
3.29
1.2
1.7
—
—
—
0
0
6
7
8.82
3.29
1.2
1.6
—
—
—
0
0
6
7
8.82
3.29
1.5
1.7
—
—
—
0
0
6
7
8.82
3.29
1.2
1.7
—
—
—
0
0
6
7
8.82
3.29
1.2
1.7
—
—
—
0
0
74
514
1.77
3.26
5.6
2.8
176.1
134.9
ug/l
0.62
64
472
10
28
3.73
3.24
1.8
1.4
—
—
—
0
0
8
15
5.53
3.23
1.5
1.3
—
—
—
0
0
121
971
1.81
3.19
12.2
7.2
86.7
80.1
u/l
0.53
111
897
84
608
1.74
3.18
7.1
5.6
0.0
0.0
estimate
0.00
15
106
53
335
1.84
3.18
1.7
1.6
18.7
20.5
nmol/l
0.34
40
284
85
619
1.73
3.14
6.2
4.2
0.0
0.0
estimate
0.00
14
101
84
611
1.72
3.11
6.3
4.1
0.0
0.0
estimate
0.00
15
108
64
432
1.76
3.08
4.5
3.4
2.3
2.4
mmol/l
0.37
51
374
71
495
1.73
3.04
6.4
4.4
—
—
—
0
0
13
46
2.97
2.99
1.5
1.9
—
—
—
0
0
7
13
5.56
2.90
1.0
1.8
—
—
—
0
0
6
9
6.85
2.89
1.2
1.7
—
—
—
0
0
6
9
6.85
2.89
1.2
1.7
—
—
—
0
0
16
65
2.61
2.88
6.3
3.0
1.3
1.2
%
0.00
16
65
11
36
3.19
2.86
1.1
1.6
—
—
—
0
0
136
1148
1.85
2.83
10.4
6.0
44.9
40.5
mmol/mol
2.69
110
1062
153
1350
2.10
2.67
43.7
23.4
126.5
133.1
g/l
4.39
144
1321
7
15
4.81
2.62
1.1
1.7
—
—
—
0
0
9
26
3.59
2.52
1.0
1.7
—
—
—
0
0
30
171
1.91
2.44
7.0
9.2
0.3
1.6
mmol/l
0.78
24
132
22
114
2.06
2.33
2.5
2.5
0.2
0.2
g/l
0.01
22
106
29
167
1.88
2.29
7.2
9.3
11.9
11.6
kpa
0.11
24
155
97
773
1.58
2.26
5.3
2.9
55.9
48.7
u/l
0.36
91
712
147
1300
1.84
2.25
16.9
10.2
23.6
24.7
u/l
0.40
131
1246
5
9
5.68
2.23
1.0
1.3
—
—
—
0
0
15
68
2.32
2.18
3.7
9.2
22.9
25.1
mmol/l
—
10
62
10
37
2.81
2.14
1.3
1.5
—
—
—
0
0
24
140
1.83
1.83
2.6
3.6
—
—
—
0
0
128
1116
1.56
1.79
20.0
14.8
68.0
76.7
ml/min/173m2
3.02
104
911
124
1075
1.53
1.77
21.1
17.1
38.8
39.1
%
0.12
50
749
38
256
1.62
1.76
1.7
1.7
1.3
1.5
mg/l
0.19
31
208
8
30
2.74
1.74
1.0
1.5
—
—
—
0
0
133
1175
1.56
1.70
6.0
4.4
4.3
4.5
mmol/l
1.50
110
1072
30
192
1.68
1.68
2.7
1.7
28.3
29.5
s
0.75
30
184
11
49
2.33
1.67
1.9
2.5
—
—
—
0
0
46
331
1.53
1.61
5.3
2.8
398.8
7084.6
umol/l
1.76
36
267
6
21
2.92
1.52
1.5
1.1
—
—
—
0
0
131
1167
1.50
1.48
6.3
4.4
1.4
1.5
mmol/l
1.68
108
1053
7
28
2.56
1.47
1.3
1.3
—
—
—
0
0
7
29
2.47
1.40
1.4
1.6
110.3
98.8
pmol/l
—
7
29
5
17
3.00
1.37
1.0
1.2
—
—
—
0
0
0
37
0.00
1.36
0.0
1.5
—
—
—
0
0
46
348
1.44
1.24
3.4
3.1
0.9
0.3
e6/l
0.47
39
268
12
64
1.94
1.21
5.5
6.2
25.6
24.6
mmol/l
0.53
12
64
17
104
1.70
1.14
2.6
2.4
62.7
65.6
g/l
0.58
12
93
7
34
2.10
1.04
2.1
1.4
—
0.0
—
0
10
5
22
2.31
1.04
1.0
1.7
—
—
—
0
0
124
1127
1.35
0.99
5.6
4.0
1.5
1.3
mmol/l
3.12
102
1010
5
23
2.21
0.98
1.0
1.1
—
—
—
0
0
28
203
1.45
0.95
3.0
2.7
1.5
1.2
e6/l
0.19
19
121
53
430
1.33
0.94
5.9
4.9
1.8
2.4
ug/l
0.72
46
374
6
28
2.18
0.92
1.2
1.3
—
—
—
0
0
131
1208
1.34
0.89
6.4
4.9
2.4
2.6
mmol/l
1.74
109
1091
23
164
1.46
0.85
1.6
1.8
—
—
—
0
0
6
32
1.91
0.82
1.5
1.4
—
—
—
0
0
47
383
1.31
0.80
3.3
3.0
38.8
33.1
u/l
0.27
47
364
5
25
2.03
0.73
1.2
1.7
—
—
—
0
0
5
26
1.95
0.71
1.0
1.1
24.0
17.8
u/l
—
5
21
22
163
1.40
0.68
1.5
1.7
—
—
—
0
0
0
22
0.00
0.59
0.0
1.7
—
—
—
0
0
9
59
1.55
0.56
1.4
1.4
—
—
—
0
0
6
39
1.56
0.53
1.5
1.2
—
—
—
0
0
6
40
1.52
0.52
1.5
1.2
—
—
—
0
0
30
247
1.26
0.48
1.3
1.3
1.3
2.6
u/ml
—
7
57
22
174
1.30
0.48
1.5
1.2
20.0
7.8
u/ml
—
6
63
11
150
0.72
0.43
1.2
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
2.6
—
233.3
—
0
16
0
17
0.00
0.41
0.0
3.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.6
—
—
—
0
0
22
181
1.25
0.36
1.3
1.2
10.1
33.3
iu/ml
—
6
60
20
238
0.82
0.31
3.7
2.8
0.7
0.9
ug/l
0.60
15
156
8
64
1.26
0.28
1.5
3.0
4.5
4.3
pmol/l
—
8
55
37
334
1.14
0.24
6.5
4.5
22.3
22.1
%
0.03
25
160
0
11
0.00
0.21
0.0
1.1
—
47.6
—
0
5
0
11
0.00
0.21
0.0
1.0
—
476.6
—
0
5
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
28
250
1.14
0.21
2.9
3.0
2.4
2.5
mmol/l
0.59
23
209
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
33
300
1.12
0.19
2.1
1.7
1.6
1.3
mmol/l
1.06
26
248
5
46
1.09
0.09
1.0
1.9
—
—
—
0
0
6
58
1.04
0.08
1.0
1.9
—
—
—
0
0
26
244
1.08
0.08
3.6
3.7
200.9
97.2
ng/l
0.34
21
193
21
195
1.09
0.08
2.8
2.9
3.4
2.2
e6/l
—
10
114
18
174
1.04
0.00
1.7
1.5
—
—
—
0
0
70
703
0.99
0.00
3.0
3.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
9
95
0.94
0.00
1.1
2.6
—
—
—
0
0
8
86
0.93
0.00
1.1
2.4
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_SEVVISIMPBINOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.435 [1.09, 1.88] | 0.009 |
| Birth year | 0.988 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 296 out of 721 females with H7_SEVVISIMPBINOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_SEVVISIMPBINOC | 1.576 [1.15, 2.15] | 0.004 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 257 out of 605 males with H7_SEVVISIMPBINOC died.
Mortality risk
Mortality risk for people of age
years, who have H7_SEVVISIMPBINOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.115% | 0.294% |
| 5 | 0.592% | 1.968% |
| 10 | 1.64% | 4.809% |
| 15 | 3.245% | 9.312% |
| 20 | 5.846% | 15.604% |
Relationships between endpoints
↥Index endpoint: H7_SEVVISIMPBINOC – Severe visual impairment, binocular
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data