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Malignant neoplasm of other and ill-defined digestive organs, excluding all cancers (controls excluding all cancers)

C3_DIGESTIVE_ORGANS_NAS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C26
  • Hospital discharge: ICD-9 15[8-9]
  • Hospital discharge: ICD-8 15[8-9]
  • Cause of death: ICD-10 C26
  • Cause of death: ICD-9 15[8-9]
  • Cause of death: ICD-8 15[8-9]
  • Cancer registry: Topography ICD-O-3 C26
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

570

4. Check minimum number of events

None

570

5. Include endpoints

None

570

6. Filter based on genotype QC (FinnGen only)

570

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and ill-defined digestive organs, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 570 276 294
Unadjusted period prevalence (%) 0.11 0.09 0.13
Median age at first event (years) 70.81 71.41 70.26

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
231
Matched controls
2307
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
123.2
107
*
C26.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the digestive system
+∞
88.3
79
*
8140/3-C26.9
ICD-O-3
Adenocarcinoma, NOS, of gastrointestinal tract, NOS
+∞
85.9
77
*
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
61.2
56
*
Z51.5
ICD-10 Finland
Palliative care
35.7
60.8
79
33
H02AB02
ATC
dexamethasone; systemic
85.7
57.8
63
10
A03FA01
ATC
metoclopramide; systemic, rectal
14.6
56.2
105
124
A04AA02
ATC
granisetron; systemic, transdermal
349.6
55.8
54
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
661.2
54.9
52
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
50.9
47
*
C26.0
ICD-10 Finland
Malignant neoplasm: Intestinal tract, part unspecified
+∞
41.9
39
*
N02AA05
ATC
oxycodone; systemic
8.7
39.5
99
183
L01BC06
ATC
capecitabine; oral
+∞
38.6
36
*
JN4BD
NOMESCO Finland
Extensive body CT
17.2
38.0
62
48
8000/3-C26.9
ICD-O-3
Neoplasm, malignant of gastrointestinal tract, NOS
+∞
37.5
35
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
34.2
32
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
358.3
31.6
31
*
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
61.4
28.0
32
6
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
27.6
26
*
JN4AD
NOMESCO Finland
Body CT examination
14.4
26.1
45
38
A04AA01
ATC
ondansetron; systemic, rectal
40.9
26.0
32
9
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
11.9
18.9
35
34
R18
ICD-10 Finland
Ascites
29.5
18.2
24
9
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
25.3
18.2
25
11
C26.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of digestive system
+∞
17.9
17
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
17.9
17
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
17.9
17
*
C80.92
ICD-10 Finland
Malignant tumor without specified localization adenocarcinoma
+∞
16.9
16
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.7
16.0
83
300
8140/3-C26.0
ICD-O-3
Adenocarcinoma, NOS, of intestinal tract, NOS
+∞
15.8
15
*
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
+∞
15.8
15
*
116
Kela drug reimbursment
Prostate cancer
+∞
15.8
15
*
WZC30
NOMESCO Finland
Teaching
5.9
15.1
44
88
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.4
14.8
92
379
B01AB10
ATC
tinzaparin; parenteral
9.7
14.8
30
35
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
14.7
14
*
JAH00
NOMESCO Finland
Laparotomy
12.6
14.7
26
23
WX302
NOMESCO Finland
Thoracal epidural anesthesy
14.7
14.6
24
18
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
24.1
14.5
20
9
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
32.3
14.1
18
6
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
13.7
13
*
8000/3-C26.0
ICD-O-3
Neoplasm, malignant of intestinal tract, NOS
+∞
13.7
13
*
8010/3-C26.9
ICD-O-3
Carcinoma, NOS, of gastrointestinal tract, NOS
+∞
12.6
12
*
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
+∞
11.5
11
*
8936/3-C26.9
ICD-O-3
Gastrointestinal stromal tumor of gastrointestinal tract, NOS
+∞
11.5
11
*
WD405
NOMESCO Finland
Simple antiboidy therapy of methastized malignancy
125.8
11.5
12
*
WD415
NOMESCO Finland
Demanding antibody therapy of methastized malignancy
125.8
11.5
12
*
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.6
11.1
40
101
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
45.6
11.0
13
*
L02AE02
ATC
leuprorelin; implant, parenteral
62.9
10.7
12
*
L03AA13
ATC
pegfilgrastim; parenteral
114.8
10.5
11
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
10.5
10
*
WF004
NOMESCO Finland
Palliative radiotherapy
+∞
10.5
10
*
A06AH03
ATC
naloxegol; oral
57.4
9.7
11
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.7
9.5
43
134
C49.49
ICD-10 Finland
Malignant tumor of connective tissue and soft tissue of the abdomen other or unspecified tumor
+∞
9.4
9
*
QX3AT
NOMESCO Finland
Ultrasound guided biopsy of subcutaneous tissue
+∞
9.4
9
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
9.4
9
*
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
9.4
9
*
D77
ICPC
Malignant digestive neopl other/NOS
+∞
9.4
9
*
H01CB03
ATC
lanreotide; parenteral
+∞
9.4
9
*
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
9.4
9
*
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
9.4
9
*
C76.2
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Abdomen
+∞
9.4
9
*
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
9.1
63
264
B01AB05
ATC
enoxaparin; parenteral
2.6
9.1
80
390
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
9.2
9.0
18
21
UJF32
NOMESCO Finland
Coloscopy
2.7
8.8
70
321
JN4CD
NOMESCO Finland
Very extensive body CT
17.1
8.6
13
8
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
8.5
84
433
JN3AD
NOMESCO Finland
Abdominal CT examination
4.6
8.5
29
70
A79
ICPC
Malignancy NOS
+∞
8.4
8
*
C80.0
ICD-10 Finland
Malignant neoplasm, primary site unknown, so stated
+∞
8.4
8
*
A04AD12
ATC
aprepitant; systemic
+∞
8.4
8
*
Y77
ICPC
Malignant neoplasm prostate
+∞
8.4
8
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.0
8.3
26
57
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.3
8.2
42
145
JAH01
NOMESCO Finland
Laparoscopy
8.2
8.0
17
22
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
25.9
7.6
10
*
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
82.5
7.5
8
*
C80.90
ICD-10 Finland
Malignant tumor without specified localization without histology
+∞
7.3
7
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
7.3
7
*
PJ2AT
NOMESCO Finland
Biopsy of lymphnode with ultrasound guidance
+∞
7.3
7
*
C56.00
ICD-10 Finland
Malignant tumor of the ovary without histology
+∞
7.3
7
*
189
Kela drug reimbursment
Imatinib
+∞
7.3
7
*
115
Kela drug reimbursment
Breast cancer
+∞
7.3
7
*
L02BG04
ATC
letrozole; oral
+∞
7.3
7
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
7.3
7
*
YL1BD
NOMESCO Finland
Extensive CT examination of pelvis for dose design of radiotherapy
+∞
7.3
7
*
YN7BD
NOMESCO Finland
Extensive CT examination of spine for dose design of radiotherapy
+∞
7.3
7
*
TPH07
NOMESCO Finland
Cathetrisation of artery
3.6
7.0
31
95
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
14.3
7.0
11
8
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
17.3
6.8
10
6
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
41.2
6.8
8
*
L03AA02
ATC
filgrastim; parenteral
41.2
6.8
8
*
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
5.0
6.6
20
43
JFF10
NOMESCO Finland
Loop enterostomy
71.6
6.5
7
*
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.8
6.4
26
74
L01XE01
ATC
[U] imatinib; oral
+∞
6.3
6
*
8240/3-C26.9
ICD-O-3
Neuroendocrine tumor, NOS, of gastrointestinal tract, NOS
+∞
6.3
6
*
C16.9
ICD-10 Finland
Malignant neoplasm: Stomach, unspecified
+∞
6.3
6
*
C17.9
ICD-10 Finland
Malignant neoplasm: Small intestine, unspecified
+∞
6.3
6
*
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
+∞
6.3
6
*
WD505
NOMESCO Finland
Simple enzyme inhibitor or similar therapy of methastized malignancy
+∞
6.3
6
*
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
+∞
6.3
6
*
8480/3-C26.9
ICD-O-3
Mucinous adenocarcinoma of gastrointestinal tract, NOS
+∞
6.3
6
*
TPX10
NOMESCO Finland
Implantation of vascular injection port
8.0
6.2
13
17

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_DIGESTIVE_ORGANS_NAS_EXALLC – Malignant neoplasm of other and ill-defined digestive organs, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).