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Malignant neoplasm of other and ill-defined sites, excluding all cancers (controls excluding all cancers)

Endpoint Browser

C3_OTHER_OR_ILLDEFINED_SITES_EXALLC

Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — C76
  • Hospital discharge: ICD-9 — 195
  • Hospital discharge: ICD-8 — 195
  • Cause of death: ICD-10 — C76
  • Cause of death: ICD-9 — 195
  • Cause of death: ICD-8 — 195
  • Cancer registry: Topography ICD-O-3 — C76
  • Cancer registry: Morphology ICD-O-3 — ANY
  • Cancer registry: Behaviour codes — 3

3 out of 7 registries used, show all original rules.

574

4. Check minimum number of events

None

574

5. Include endpoints

None

574

6. Filter based on genotype QC (FinnGen only)

574

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

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List of similar endpoints to Malignant neoplasm of other and ill-defined sites, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

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FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

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-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 574 260 314
Unadjusted period prevalence (%) 0.12 0.09 0.14
Median age at first event (years) 67.38 65.07 69.30

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
88
Matched controls
881
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C76.2
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Abdomen
+∞
37.1
33
*
130
Kela drug reimbursment
Malignant tumour
+∞
22.9
21
*
8000/3-C76.2
ICD-O-3
Neoplasm, malignant of abdomen, NOS
+∞
12.8
12
*
8140/3-C76.2
ICD-O-3
Adenocarcinoma, NOS, of abdomen, NOS
+∞
11.7
11
*
H02AB02
ATC
dexamethasone; systemic
37.6
10.7
13
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
10.6
10
*
8000/3-C80.9
ICD-O-3
Neoplasm, malignant of unknown primary site
+∞
9.5
9
*
A03FA01
ATC
metoclopramide; systemic, rectal
6.2
8.6
24
50
C80
ICD-10 Finland
Malignant neoplasm, without specification of site
+∞
8.5
8
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
7.4
7
*
C80.90
ICD-10 Finland
Malignant tumor without specified localization without histology
+∞
7.4
7
*
C76.1
ICD-10 Finland
Malignant neoplasm of other and ill-defined sites: Thorax
+∞
6.3
6
*
C26.9
ICD-10 Finland
Malignant neoplasm: Ill-defined sites within the digestive system
+∞
6.3
6
*
8000/3-C76.1
ICD-O-3
Neoplasm, malignant of thorax, NOS
+∞
6.3
6
*
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
6.3
6
*
8140/3-C80.9
ICD-O-3
Adenocarcinoma, NOS, of unknown primary site
+∞
6.3
6
*

Mortality – FinRegistry

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This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

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Index endpoint: C3_OTHER_OR_ILLDEFINED_SITES_EXALLC – Malignant neoplasm of other and ill-defined sites, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).