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Melanocytic naevi of scalp and neck

DOID EFO Endpoint Browser PheWeb

CD2_BENIGN_MELANOCYTIC_SCALPNECK

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D22.4&
  • Hospital discharge: ICD-9 — 2164A
  • Cause of death: ICD-10 — D22.4&
  • Cause of death: ICD-9 — 2164A

2 out of 7 registries used, show all original rules.

902

4. Check minimum number of events

None

902

5. Include endpoints

None

902

6. Filter based on genotype QC (FinnGen only)

902

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D22
Name in latin
Naevus melanocyticus (cutis) verticis cranii

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6814 3784 3011
Only index persons 6315 3553 2762
Unadjusted period prevalence (%)
Whole population 0.10 0.11 0.08
Only index persons 0.12 0.13 0.11
Median age at first event (years)
Whole population 35.03 34.26 35.95
Only index persons 36.18 35.14 37.52

-FinnGen-

Key figures

All Female Male
Number of individuals 902 559 343
Unadjusted period prevalence (%) 0.18 0.19 0.15
Median age at first event (years) 47.24 41.58 56.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
803
Matched controls
8029
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D22.4
ICD-10 Finland
Melanocytic naevi of scalp and neck
5081.2
323.0
769
26
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
19.6
212.7
349
303
QBE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin of trunk
6.9
56.7
152
261
D22.5
ICD-10 Finland
Melanocytic naevi of trunk
6.3
45.9
131
241
QAE99
NOMESCO Finland
Other excision or repair surgery of skin and subcutaneous tissue in head and neck
15.6
41.6
69
48
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.6
37.9
143
359
2164A
ICD-9 Finland
Benign neoplasm of skin, Scalp and skin of neck[PÄÄN JA KAULAN IHON BEN KASV,NAEVUS PIGMENTOSUS]
+∞
34.6
33
*
TQW99
NOMESCO Finland
Other minor procedure on skin
7.0
30.5
78
122
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
11.5
26.7
50
46
L82
ICD-10 Finland
Seborrhoeic keratosis
2.8
21.0
148
592
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
4.3
20.0
76
189
D22.9
ICD-10 Finland
Melanocytic naevi, unspecified
4.7
19.6
69
159
L57.0
ICD-10 Finland
Actinic keratosis
3.5
18.6
91
282
D22.3
ICD-10 Finland
Melanocytic naevi of other and unspecified parts of face
6.7
18.3
47
74
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
5.7
16.4
47
86
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.4
15.8
144
663
9733
FHL
Excision of skin change in operating room or anesthesia
8.6
14.1
30
36
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
3.5
13.8
65
196
D03.4
ICD-10 Finland
Melanoma in situ of scalp and neck
+∞
13.6
13
*
ZZR00
NOMESCO Finland
Flap of skin
7.0
13.3
32
47
S18
ICPC
Laceration/cut
1.8
13.0
311
2093
QAE00
NOMESCO Finland
Excision of loose skin or fold of skin from head and neck
28.9
13.0
17
6
QBE99
NOMESCO Finland
Other excision or repair of lesion of skin of trunk
7.2
12.7
30
43
D23.4
ICD-10 Finland
Benign neoplasm: Skin of scalp and neck
9.2
12.3
25
28
XQ848
NOMESCO Finland
Dermatological photography
5.0
11.2
35
72
XQ845
NOMESCO Finland
Dermatoscopy
8.2
11.1
24
30
QCE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in upper limb
4.8
11.0
36
78
QXA25
NOMESCO Finland
Destruction of lesion of skin, site unspecified
4.6
11.0
37
83
D22.7
ICD-10 Finland
Melanocytic naevi of lower limb, including hip
5.4
10.7
31
59
SPAT1153
SPAT
Removal of sutures
1.7
10.3
237
1552
S82
ICPC
Naevus/mole
2.2
10.2
113
565
R22.0
ICD-10 Finland
Localized swelling, mass and lump, head
3.9
9.8
39
103
C43.52
ICD-10 Finland
Malignant melanoma on the torso: 'superficial spreading' type
9.2
9.6
19
21
D23.3
ICD-10 Finland
Benign neoplasm: Skin of other and unspecified parts of face
4.9
9.5
30
63
C43.50
ICD-10 Finland
Malignant melanoma of the torso without histology
22.0
9.4
13
6
C44.41
ICD-10 Finland
Basocellular carcinoma of the skin of the scalp and neck
8.4
9.1
19
23
Z94.0
ICD-10 Finland
Kidney transplant status
7.6
9.0
20
27
EP1AE
NOMESCO Finland
Neck ultrasound examination
2.9
8.6
50
178
C43.42
ICD-10 Finland
Malignant melanoma of the scalp and neck: 'superficial spreading' type
91.0
8.4
9
*
L72.1
ICD-10 Finland
Trichilemmal cyst
2.7
8.3
56
218
C44.51
ICD-10 Finland
Basocellular carcinoma of the skin on the torso
4.4
8.2
28
65
D04.3
ICD-10 Finland
Carcinoma in situ: Skin of other and unspecified parts of face
5.8
8.2
22
39
C43.59
ICD-10 Finland
Malignant melanoma of the trunk other or unspecified histology
13.2
7.9
13
10
127
Kela drug reimbursment
Transplant complication
5.5
7.9
22
41
B05DA
ATC
Isotonic solutions
10.9
7.8
14
13
137
Kela drug reimbursment
Uraemia requiring dialysis
9.0
7.6
15
17
8720/3-C44.5
ICD-O-3
Malignant melanoma, NOS, of skin of trunk
8.9
7.1
14
16
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
2.7
7.0
46
179
180
Kela drug reimbursment
Interferon alfa
16.9
6.8
10
6
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.3
6.7
23
55
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.5
6.6
307
2349
ZXC50
NOMESCO Finland
Cryotherapy
3.9
6.6
25
65
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
7.5
6.4
14
19
L04AA01
ATC
[U] ciclosporin; systemic
5.6
6.3
17
31
J01DB01
ATC
cefalexin; oral
1.5
6.3
624
5568
362
Kela drug reimbursment
Dabrafenib, trametinib and vemurafenib
+∞
6.3
6
*
L91.0
ICD-10 Finland
Hypertrophic scar
4.7
6.1
19
41
B05DB
ATC
Hypertonic solutions
12.6
6.1
10
8
D22.6
ICD-10 Finland
Melanocytic naevi of upper limb, including shoulder
5.0
6.1
18
37
Z49.2
ICD-10 Finland
Other dialysis
8.7
6.1
12
14
QAA25
NOMESCO Finland
Destruction of lesion of head or neck
4.0
6.0
22
56

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
493
2886
2.56
41.73
2.7
2.0
—
—
—
0
0
192
895
2.45
24.44
1.6
1.2
—
—
—
0
0
67
289
2.42
9.84
1.4
1.2
—
—
—
0
0
367
2843
1.49
7.61
6.0
4.7
36.4
36.1
g/l
0.37
354
2655
100
559
1.89
7.55
1.6
1.4
—
—
—
0
0
110
666
1.74
6.39
2.7
2.5
1.7
1.8
%
0.20
100
598
84
474
1.85
6.17
2.4
2.5
68.3
71.2
e9/l
0.36
60
354
650
5782
1.44
5.66
4.0
3.9
14.6
14.6
pmol/l
0.19
606
5299
749
6854
1.55
5.65
4.9
4.6
1.8
2.0
mu/l
0.57
710
6340
453
3809
1.38
5.35
7.5
5.7
0.2
0.2
e9/l
0.07
397
3388
431
3597
1.38
5.32
7.6
5.9
10.2
10.9
umol/l
1.62
414
3402
801
7470
1.65
5.28
15.9
12.6
21.7
22.1
mg/l
0.11
622
5869
833
7852
1.80
5.25
11.8
9.4
25.1
26.4
u/l
1.53
816
7602
48
237
2.08
5.20
1.3
1.2
—
—
—
0
0
449
3796
1.36
5.00
7.2
5.5
1.9
1.9
e9/l
0.28
394
3392
437
3683
1.36
4.95
7.2
5.5
0.0
0.0
e9/l
0.13
380
3228
174
1256
1.48
4.82
3.6
3.6
397.5
304.7
ng/l
0.21
129
890
16
50
3.24
4.35
1.2
1.4
5.7
6.5
ug/l
0.31
16
40
390
3276
1.34
4.32
9.0
6.6
1.2
1.2
mmol/l
0.12
339
2793
430
3668
1.33
4.27
7.3
5.5
0.6
0.6
e9/l
0.22
375
3212
9
13
6.98
4.17
4.4
3.8
—
—
—
0
0
870
8382
2.07
4.11
23.6
18.4
255.6
253.2
e9/l
0.54
861
8189
10
23
4.39
4.09
3.3
2.9
—
—
—
0
0
100
664
1.57
4.08
2.9
2.5
26.9
34.8
u/l
1.94
85
558
827
7856
1.63
4.06
14.1
11.8
—
—
—
0
0
27
117
2.35
4.04
1.2
1.2
—
—
—
0
0
870
8387
2.05
4.02
23.6
18.4
4.5
4.5
e12/l
0.08
858
8177
870
8391
2.04
3.95
23.6
18.4
6.7
6.7
e9/l
0.41
858
8174
352
2942
1.32
3.94
8.3
5.8
1.2
1.2
mmol/l
0.13
317
2673
293
2385
1.34
3.94
8.0
5.5
—
—
—
0
0
415
3551
1.31
3.92
7.0
5.4
57.2
56.9
%
0.23
386
3345
82
525
1.62
3.90
9.6
8.7
—
—
—
0
0
486
4255
1.31
3.86
11.0
8.3
4.0
4.1
e9/l
0.15
430
3744
223
1761
1.35
3.63
6.1
3.6
94.4
92.3
%
0.57
215
1707
416
3593
1.29
3.55
7.2
5.6
28.1
28.5
%
0.28
388
3376
21
87
2.45
3.49
2.4
2.3
—
—
—
0
0
210
1657
1.35
3.42
3.8
3.4
—
—
—
0
0
761
7157
1.40
3.40
4.3
4.0
4.7
4.7
mmol/l
0.05
728
6692
402
3477
1.28
3.33
7.6
5.9
8.4
8.4
%
0.08
375
3276
785
7434
1.43
3.26
17.6
14.0
139.6
139.6
mmol/l
0.15
776
7230
732
6854
1.36
3.24
3.9
3.6
1.2
1.3
mmol/l
0.69
690
6364
97
675
1.49
3.22
1.5
1.5
—
—
—
0
0
598
5449
1.29
3.20
9.7
7.0
76.9
77.0
u/l
0.02
575
5112
744
6991
1.37
3.17
4.4
4.1
5.8
5.8
mmol/l
0.06
707
6429
120
875
1.43
3.13
3.5
2.3
22.6
23.2
%
0.20
105
750
398
3457
1.27
3.12
7.3
5.6
2.7
2.8
%
0.56
368
3240
769
7269
1.39
3.11
4.7
4.4
2.8
2.8
mmol/l
0.43
739
6753
253
2077
1.30
3.09
3.4
3.2
7.6
7.9
mmol/l
0.45
221
1754
308
2605
1.28
2.97
10.0
7.7
1.2
1.2
inr
0.11
65
779
17
69
2.49
2.97
1.1
1.4
—
—
—
0
0
785
7460
1.40
2.95
17.9
14.1
3.9
3.9
mmol/l
0.86
774
7241
140
1060
1.38
2.95
1.7
1.6
—
—
—
0
0
85
587
1.49
2.94
4.6
3.5
1.8
1.9
mmol/l
0.17
70
464
462
4110
1.25
2.88
5.7
4.6
6.4
6.6
mmol/l
1.68
413
3784
16
64
2.53
2.88
1.9
2.8
1.0
1.2
e9/l
—
9
31
116
854
1.41
2.88
1.5
1.4
—
—
—
0
0
7
13
5.42
2.87
2.1
1.6
—
—
—
0
0
87
608
1.48
2.85
4.6
3.6
—
—
—
0
0
154
1198
1.34
2.73
3.5
2.7
2.4
2.4
mmol/l
0.20
139
1051
254
2118
1.28
2.71
2.7
2.9
—
—
—
0
0
115
855
1.40
2.71
2.3
1.7
—
—
—
0
0
753
7132
1.34
2.69
4.2
4.0
1.5
1.5
mmol/l
0.40
720
6639
218
1786
1.29
2.67
2.4
2.0
2.6
2.9
mg/l
0.81
183
1521
78
541
1.48
2.66
4.6
3.4
—
—
—
0
0
138
1062
1.35
2.63
4.6
3.4
0.8
0.8
mmol/l
0.01
127
1002
54
347
1.59
2.60
1.4
1.3
259.1
244.7
miu/ml
0.11
32
166
64
428
1.53
2.60
1.3
1.3
—
—
—
0
0
234
1942
1.28
2.58
6.3
3.7
7.4
7.4
ph
0.12
31
355
141
1092
1.35
2.58
2.9
2.7
2.1
2.6
e6/l
0.41
87
585
8
20
4.03
2.57
2.0
1.4
—
—
—
0
0
29
157
1.88
2.55
1.7
1.5
—
—
—
0
0
310
2664
1.25
2.54
2.0
1.9
96.5
96.1
pmol/l
0.05
154
1424
112
840
1.38
2.51
9.9
5.5
1.1
1.0
mmol/l
0.48
106
780
380
3348
1.23
2.47
7.4
5.7
0.7
0.7
%
0.71
354
3143
236
1972
1.27
2.46
2.2
2.1
160.5
262.6
u/l
1.15
220
1860
135
1048
1.34
2.43
3.3
2.3
13.3
13.6
umol/l
0.24
128
967
51
330
1.58
2.40
9.9
10.4
24.1
24.3
mmol/l
0.21
44
311
7
17
4.14
2.36
1.0
1.0
—
—
—
0
0
533
4880
1.23
2.34
4.5
4.2
18.4
2533.7
e6/l
—
5
68
95
707
1.38
2.25
7.1
8.5
5.0
5.1
kpa
0.86
88
678
291
2513
1.23
2.24
4.0
3.5
27.7
90.6
e6/l
2.99
205
1711
48
312
1.57
2.24
5.7
3.4
24.2
24.0
mmol/l
0.19
43
282
95
708
1.38
2.23
7.1
8.5
12.5
12.6
kpa
0.05
88
681
216
1806
1.26
2.22
9.9
6.2
—
—
—
0
0
397
3544
1.21
2.20
4.5
4.0
—
—
—
0
0
50
331
1.54
2.16
8.2
11.8
—
—
—
0
0
109
835
1.35
2.16
4.2
2.6
6.2
7.3
umol/l
0.58
93
718
17
81
2.12
2.13
8.2
5.9
13.6
11.0
mg/l
0.68
17
74
94
706
1.37
2.11
7.3
8.5
0.1
1.1
mmol/l
2.00
71
554
552
5102
1.21
2.09
4.5
4.1
—
—
—
0
0
28
161
1.76
2.08
1.2
1.3
258.8
252.5
u/ml
0.04
13
94
0
55
0.00
2.07
0.0
1.1
—
—
—
0
0
69
494
1.43
2.05
1.3
1.3
275.1
214.3
u/ml
0.22
64
453
222
1879
1.24
2.04
3.5
2.9
0.2
0.5
e6/l
2.54
170
1387
244
2088
1.23
2.02
3.4
3.0
55.5
103.3
e6/l
0.52
192
1589
268
2316
1.22
2.02
2.9
2.3
—
—
—
0
0
214
1806
1.24
2.02
3.7
3.3
450.1
261.9
mg/l
0.21
134
1185
678
6408
1.23
2.00
19.1
15.1
13.6
13.5
%
0.30
671
6286
16
77
2.10
1.97
1.4
1.6
—
—
—
0
0
27
157
1.74
1.94
1.9
1.5
0.3
0.3
nmol/l
0.07
22
135
5
11
4.56
1.94
3.4
3.1
—
—
—
0
0
22
120
1.85
1.94
1.2
1.4
—
—
—
0
0
6
16
3.77
1.93
1.0
1.1
—
—
—
0
0
18
92
1.98
1.91
1.9
1.5
—
—
—
0
0
18
92
1.98
1.91
1.9
1.5
—
—
—
0
0
18
92
1.98
1.91
1.9
1.5
—
—
—
0
0
18
92
1.98
1.91
1.9
1.5
—
—
—
0
0
209
1770
1.24
1.90
2.8
2.2
—
—
—
0
0
735
7023
1.25
1.87
17.9
13.4
40.1
40.1
%
0.04
569
5397
68
495
1.40
1.86
1.6
1.4
—
—
—
0
0
44
642
0.67
1.86
4.6
3.5
—
—
—
0
0
252
2187
1.21
1.80
3.2
2.5
56.5
56.2
u/l
0.05
237
2026
9
35
2.59
1.80
1.2
1.1
834.9
1516.8
miu/ml
—
9
35
191
1613
1.23
1.78
1.8
1.7
—
—
—
0
0
216
1849
1.22
1.77
3.6
2.9
—
—
—
0
0
64
466
1.40
1.76
3.0
3.0
66.5
66.8
g/l
0.14
57
431
45
307
1.49
1.74
1.3
1.3
—
—
—
0
0
262
2290
1.20
1.73
4.5
3.1
2.4
2.4
mmol/l
0.69
231
2031
192
1628
1.23
1.73
3.8
3.6
1.0
1.0
kg/l
1.00
24
217
97
758
1.31
1.71
1.4
1.3
—
—
—
0
0
39
259
1.53
1.71
3.6
3.5
0.5
0.3
g/l
0.96
22
114
31
477
0.64
1.70
1.7
1.6
—
—
—
0
0
678
6450
1.21
1.66
5.4
5.2
38.5
39.1
mmol/mol
0.95
645
6040
17
90
1.91
1.66
2.6
3.0
—
—
—
0
0
101
799
1.30
1.64
8.3
6.8
104.6
104.3
mmol/l
0.34
101
776
6
20
3.01
1.58
1.2
1.2
—
—
—
0
0
41
283
1.47
1.52
1.4
1.4
10.5
9.2
u/l
0.22
34
240
35
234
1.52
1.51
2.3
1.7
47.5
39.6
nmol/l
0.73
35
223
63
472
1.36
1.49
1.2
1.2
—
—
—
0
0
64
481
1.36
1.49
2.8
2.3
10975.7
4065.5
u/l
0.55
29
206
18
102
1.78
1.45
1.8
3.5
2.5
1.5
%
0.27
13
85
120
986
1.25
1.45
2.4
2.0
—
—
—
0
0
21
125
1.70
1.44
1.4
1.2
1.8
6.8
u/ml
1.55
14
49
14
73
1.93
1.44
2.7
1.2
—
—
—
0
0
7
29
2.42
1.39
2.6
1.5
—
—
—
0
0
215
1882
1.19
1.38
5.0
4.8
2.1
2.5
ug/l
0.75
194
1681
201
1750
1.19
1.38
3.6
2.6
351.2
6516.0
umol/l
6.70
177
1535
17
97
1.77
1.35
1.3
1.3
—
—
—
0
0
6
24
2.51
1.30
1.3
1.3
—
—
—
0
0
58
440
1.34
1.30
1.4
1.4
26.7
24.4
iu/l
0.21
50
381
216
1903
1.18
1.29
4.2
4.1
16.1
8.6
mg/mmol
0.91
132
1239
18
107
1.70
1.26
2.6
2.6
—
—
—
0
0
51
381
1.36
1.26
2.5
2.5
—
—
—
0
0
46
338
1.38
1.26
1.6
1.8
—
—
—
0
0
201
1767
1.18
1.23
4.4
4.1
—
—
—
0
0
223
1978
1.17
1.22
2.0
2.0
—
—
—
0
0
383
3540
1.14
1.19
3.3
2.8
89.1
102.5
ug/l
1.27
369
3300
17
102
1.68
1.17
2.5
2.7
5.7
45.6
u/ml
0.49
17
92
563
5344
1.14
1.16
4.3
3.8
10.6
10.8
mm/h
0.13
532
4954
8
39
2.06
1.15
4.8
7.6
—
—
—
0
0
0
35
0.00
1.15
0.0
1.0
—
5.9
—
0
7
163
1417
1.18
1.14
2.8
2.4
4.1
6.9
e6/l
2.54
146
1243
10
51
1.97
1.11
1.6
2.5
—
—
—
0
0
12
66
1.83
1.09
1.6
1.3
—
—
—
0
0
127
1088
1.19
1.06
3.0
2.9
0.7
0.8
ug/l
0.36
85
693
188
1665
1.16
1.06
1.9
1.7
1.1
1.0
mg/l
0.18
146
1251
7
33
2.13
1.05
1.0
1.2
—
—
—
0
0
14
82
1.72
1.05
1.3
1.2
—
—
—
0
0
52
404
1.30
1.03
1.6
1.8
—
—
—
0
0
27
188
1.45
1.02
1.3
1.3
—
—
—
0
0
391
3654
1.12
0.98
3.6
3.4
0.0
0.0
estimate
0.00
52
711
195
1743
1.15
0.97
5.3
4.2
—
—
—
0
0
188
2097
0.87
0.96
2.9
3.1
—
—
—
0
0
32
234
1.38
0.94
2.0
2.6
—
—
—
0
0
9
52
1.74
0.92
1.8
1.4
—
—
—
0
0
28
201
1.41
0.92
1.4
1.4
257.9
310.5
ug/g
0.44
13
117
65
529
1.25
0.91
2.8
2.5
9.7
7.0
ug/l
0.30
59
476
173
1545
1.15
0.88
1.6
1.5
19.7
20.6
nmol/l
0.35
158
1325
71
587
1.23
0.87
4.1
4.3
2.9
20.8
ug/l
1.42
57
482
116
1011
1.17
0.82
2.4
2.3
127.7
117.7
ug/g
0.18
91
792
118
1030
1.17
0.82
1.4
1.3
313.1
470.5
titre
1.77
29
206
6
32
1.88
0.82
1.5
4.5
—
—
—
0
0
10
58
1.73
0.80
2.0
2.4
865.0
778.4
e6/l
—
5
26
54
439
1.24
0.79
1.5
1.7
—
—
—
0
0
0
27
0.00
0.77
0.0
1.3
—
70.8
—
0
18
54
441
1.24
0.76
1.5
1.7
—
—
—
0
0
392
3707
1.10
0.74
3.6
3.5
0.0
0.0
estimate
0.80
49
686
54
443
1.23
0.74
1.5
1.7
—
—
—
0
0
508
4866
1.10
0.74
3.8
3.5
—
—
—
0
0
58
480
1.22
0.73
2.7
3.4
4.7
4.6
pmol/l
0.14
51
426
189
1721
1.12
0.73
3.3
3.1
2674.7
1159.5
ng/l
1.10
169
1447
9
56
1.61
0.72
2.2
1.2
—
—
—
0
0
75
638
1.19
0.72
6.9
4.1
—
—
—
0
0
11
68
1.63
0.72
2.2
1.1
—
—
—
0
0
51
618
0.81
0.71
1.2
1.2
72.5
152.2
iu/ml
1.85
18
258
5
26
1.93
0.70
1.6
2.0
—
—
—
0
0
57
474
1.22
0.70
1.2
1.3
—
31.6
—
0
27
64
539
1.20
0.69
2.8
2.3
11.0
12.2
nmol/l
0.53
57
484
9
59
1.53
0.68
1.0
1.1
312.3
218.3
mg/l
—
9
52
386
3660
1.10
0.68
4.9
4.7
0.0
0.0
estimate
0.50
52
715
63
531
1.20
0.68
1.3
1.4
—
—
—
0
0
53
439
1.22
0.68
1.5
1.6
—
—
—
0
0
47
385
1.23
0.67
5.5
8.1
23.2
24.5
mmol/l
1.41
42
360
349
3297
1.10
0.66
9.9
8.3
0.0
0.0
e9/l
0.78
276
2701
5
28
1.79
0.66
5.0
3.2
48.5
34.6
umol/l
—
5
20
7
44
1.60
0.65
1.3
1.2
—
—
—
0
0
8
127
0.63
0.64
1.0
1.0
—
—
—
0
0
12
79
1.53
0.63
1.2
2.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
255
2721
0.91
0.60
2.3
2.6
—
—
—
0
0
0
21
0.00
0.60
0.0
1.9
—
16.5
—
0
21
25
192
1.31
0.59
2.6
3.3
—
—
—
0
0
8
52
1.54
0.59
1.1
1.5
—
—
—
0
0
21
157
1.35
0.59
2.0
1.8
160.2
209.6
pmol/l
0.79
21
147
7
112
0.62
0.58
1.3
1.6
—
—
—
0
0
37
301
1.24
0.57
2.0
2.4
—
—
—
0
0
16
115
1.40
0.57
1.2
1.2
—
—
—
0
0
32
257
1.25
0.56
1.3
1.2
—
—
—
0
0
78
884
0.87
0.54
1.2
1.3
—
—
—
0
0
9
62
1.46
0.53
1.1
1.1
60.1
41.1
mg/l
—
9
48
6
39
1.54
0.53
1.0
1.0
—
—
—
0
0
40
333
1.21
0.52
2.1
2.4
—
—
—
0
0
9
64
1.41
0.51
3.0
3.7
—
—
—
0
0
7
45
1.56
0.49
1.1
1.0
—
—
—
0
0
7
109
0.64
0.48
1.0
1.0
—
0.8
—
0
25
105
951
1.12
0.47
1.2
1.2
—
—
—
0
0
7
48
1.46
0.47
1.1
1.0
—
—
—
0
0
37
310
1.20
0.46
1.8
1.8
—
—
—
0
0
5
81
0.62
0.46
5.6
8.0
6.6
6.8
mmol/l
—
5
64
5
83
0.60
0.46
1.2
1.0
—
—
—
0
0
7
50
1.40
0.45
1.0
1.0
—
0.4
—
0
15
7
51
1.38
0.44
1.3
1.2
—
—
—
0
0
28
339
0.82
0.43
3.5
3.3
—
—
—
0
0
9
131
0.68
0.43
1.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.1
—
—
—
0
0
16
123
1.31
0.40
1.3
1.4
—
—
—
0
0
0
18
0.00
0.40
0.0
2.5
—
—
—
0
0
29
242
1.20
0.39
5.7
4.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
40
346
1.16
0.37
1.0
1.1
—
—
—
0
0
20
162
1.24
0.35
1.5
2.1
4.6
4.8
umol/l
0.05
14
116
9
126
0.71
0.35
1.0
1.4
—
—
—
0
0
42
478
0.87
0.34
2.9
2.8
—
—
—
0
0
85
780
1.10
0.33
22.9
21.9
1.3
1.2
inr
0.42
17
123
80
732
1.10
0.33
1.5
1.4
—
—
—
0
0
15
119
1.26
0.32
1.2
1.2
—
—
—
0
0
92
994
0.92
0.31
1.4
1.5
—
—
—
0
0
18
147
1.23
0.31
2.2
1.2
—
—
—
0
0
7
54
1.30
0.30
1.0
1.2
—
—
—
0
0
7
55
1.27
0.30
2.9
1.6
0.8
1.0
g/l
—
7
55
7
57
1.23
0.29
1.0
1.2
—
—
—
0
0
7
57
1.23
0.29
1.6
1.4
—
—
—
0
0
46
512
0.89
0.28
5.5
3.6
1.2
1.2
mmol/l
0.01
40
445
8
63
1.27
0.28
1.8
1.7
32.8
33.1
pg
—
8
63
15
122
1.23
0.27
2.8
2.4
—
—
—
0
0
13
160
0.81
0.26
2.8
2.1
—
—
—
0
0
44
396
1.12
0.26
3.9
5.8
—
—
—
0
0
117
1239
0.94
0.25
1.3
1.2
16.4
10.0
u/ml
0.34
47
488
73
676
1.09
0.25
2.6
1.9
355.1
379.0
nmol/l
0.48
67
630
175
1828
0.95
0.25
1.7
1.7
1.4
1.4
mmol/l
0.32
159
1546
12
96
1.25
0.24
2.6
1.6
—
—
—
0
0
9
77
1.17
0.24
2.0
4.2
—
—
—
0
0
14
115
1.22
0.23
1.1
1.2
—
—
—
0
0
7
92
0.76
0.22
1.1
1.3
—
—
—
0
0
20
231
0.86
0.22
6.7
9.5
—
—
—
0
0
55
507
1.09
0.22
3.5
4.4
0.0
0.8
%
0.64
15
126
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.6
2.4
44.8
48.3
umol/l
—
5
35
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
61
569
1.08
0.19
3.5
4.2
1.1
1.0
%
0.04
19
168
6
52
1.15
0.19
1.2
1.1
—
—
—
0
0
6
53
1.13
0.18
1.0
1.3
—
—
—
0
0
11
132
0.83
0.18
7.4
3.5
4.6
4.5
e9/l
0.04
11
132
117
1120
1.05
0.17
1.7
1.7
1244.3
1168.8
nmol/l
0.32
86
857
193
1871
1.04
0.17
3.9
3.6
—
—
—
0
0
10
83
1.21
0.15
1.9
2.8
—
—
—
0
0
168
1631
1.04
0.14
1.6
1.4
2.1
2.3
g/l
1.16
102
1013
14
122
1.15
0.13
2.5
2.3
17.6
16.0
%
—
8
62
11
128
0.86
0.13
2.5
2.3
—
—
—
0
0
90
937
0.96
0.13
1.9
1.8
—
—
—
0
0
28
304
0.92
0.13
1.5
1.5
—
—
—
0
0
33
308
1.07
0.11
4.5
3.6
—
—
—
0
0
14
157
0.89
0.11
1.1
1.1
—
—
—
0
0
12
136
0.88
0.11
7.2
3.8
58.6
58.5
%
0.01
12
136
15
167
0.90
0.10
4.5
4.2
—
—
—
0
0
254
2497
1.02
0.10
3.7
3.5
95.5
34.8
ng/l
1.05
151
1559
199
1950
1.03
0.10
4.4
3.7
0.0
0.0
estimate
0.23
51
695
56
535
1.05
0.10
3.5
4.3
0.0
0.1
%
3.93
17
149
11
96
1.15
0.10
1.1
1.4
0.6
0.5
nmol/l
0.60
11
88
134
1375
0.97
0.10
1.4
1.6
56302975.6
22289586.5
pmol/l
0.26
119
1162
14
156
0.90
0.10
1.1
1.1
—
—
—
0
0
53
506
1.05
0.10
2.6
2.6
3.8
4.2
e9/l
0.69
45
414
54
516
1.05
0.10
3.3
4.1
0.5
0.6
%
0.10
12
121
5
44
1.14
0.10
3.0
1.7
0.0
1.3
u/field
—
5
33
5
44
1.14
0.10
1.2
1.2
—
—
—
0
0
232
2360
0.98
0.10
1.6
1.6
—
—
—
0
0
5
45
1.11
0.10
1.4
1.4
—
—
—
0
0
5
47
1.06
0.09
2.8
3.7
—
—
—
0
0
137
1339
1.03
0.09
2.9
2.6
505.6
561.8
mosm/kgh2o
2.40
113
1146
28
298
0.94
0.08
1.4
1.4
—
—
—
0
0
6
58
1.03
0.08
1.3
1.4
—
—
—
0
0
13
117
1.11
0.08
1.5
1.6
—
—
—
0
0
14
154
0.91
0.08
1.1
1.1
16.8
8.8
u/ml
—
6
86
14
127
1.10
0.08
2.2
1.8
—
—
—
0
0
32
337
0.95
0.07
1.0
1.1
—
—
—
0
0
65
629
1.04
0.07
1.1
1.2
—
—
—
0
0
20
186
1.08
0.07
1.1
1.2
—
—
—
0
0
28
296
0.94
0.07
1.4
1.4
—
—
—
0
0
9
84
1.07
0.07
1.1
1.3
—
—
nmol/l
—
0
0
9
84
1.07
0.07
2.4
2.8
—
—
—
0
0
12
109
1.10
0.06
1.2
1.1
—
—
—
0
0
131
1291
1.02
0.04
1.3
1.3
40.7
29.5
iu/ml
0.33
37
402
43
417
1.03
0.04
4.6
3.7
7.4
7.4
ph
—
5
48
187
1854
1.01
0.03
1.3
1.3
2.7
1.6
u/ml
0.47
47
493
16
169
0.95
0.03
1.3
1.3
—
—
—
0
0
22
228
0.96
0.02
3.7
4.2
1.9
1.3
mmol/l
0.63
22
223
12
113
1.06
0.02
3.3
2.9
—
—
—
0
0
14
133
1.05
0.01
3.1
2.8
—
—
—
0
0
20
194
1.03
0.00
1.8
2.1
—
—
—
0
0
19
196
0.97
0.00
4.0
4.0
3.9
3.9
mmol/l
0.08
19
179
15
152
0.99
0.00
1.1
1.7
39965.8
15969.8
e6/l
—
9
114
16
158
1.01
0.00
1.1
1.1
—
—
—
0
0
123
1228
1.00
0.00
1.8
1.7
—
—
—
0
0
16
157
1.02
0.00
2.2
2.3
42.6
115.5
ug/min
—
9
97
13
131
0.99
0.00
1.5
1.8
—
—
—
0
0
10
99
1.01
0.00
1.2
1.5
—
—
—
0
0
14
141
0.99
0.00
1.1
1.1
—
10.5
—
0
13
23
233
0.99
0.00
1.1
1.2
—
—
—
0
0
29
293
0.99
0.00
1.7
1.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
15.8
—
0
7
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
55
0.91
0.00
1.2
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.6
—
—
—
0
0
5
55
0.91
0.00
3.2
1.2
1.0
1.4
nmol/l
—
5
50
0
7
0.00
0.00
0.0
5.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
6.5
—
0
6
0
6
0.00
0.00
0.0
1.0
—
331.2
—
0
6
13
130
1.00
0.00
2.7
4.0
—
—
—
0
0
6
61
0.98
0.00
1.0
1.6
—
—
—
0
0
7
76
0.92
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
6
61
0.98
0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
19.2
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
1.3
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.3
—
—
—
0
0
6
64
0.94
0.00
2.7
2.8
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint CD2_BENIGN_MELANOCYTIC_SCALPNECK and mortality.

Females

Parameter HR [95% CI] p-value
CD2_BENIGN_MELANOCYTIC_SCALPNECK 0.786 [0.65, 0.95] 0.011
Birth year 0.992 [0.98, 1.0] 0.06

During the follow-up period (1.1.1998 — 31.12.2019), 169 out of 3036 females with CD2_BENIGN_MELANOCYTIC_SCALPNECK died.

Males

Parameter HR [95% CI] p-value
CD2_BENIGN_MELANOCYTIC_SCALPNECK 1.089 [0.92, 1.3] 0.336
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 295 out of 2431 males with CD2_BENIGN_MELANOCYTIC_SCALPNECK died.

Mortality risk

Mortality risk for people of age

years, who have CD2_BENIGN_MELANOCYTIC_SCALPNECK.

N-year risk Females Males
1 0.068% 0.168%
5 0.421% 1.092%
10 1.019% 2.71%
15 1.971% 5.418%
20 3.539% 9.434%

Relationships between endpoints

↥

Index endpoint: CD2_BENIGN_MELANOCYTIC_SCALPNECK – Melanocytic naevi of scalp and neck

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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