Protein-energy malnutrition of moderate and mild degree

E4_PROTMALMODMILD

protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.

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Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

473681

1. Apply sex-specific rule

None

473681

2. Check conditions

None

473681

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 E44
  • Hospital discharge: ICD-9 263
  • Hospital discharge: excluded ICD-9 2632
  • Cause of death: ICD-10 E44
  • Cause of death: ICD-9 263
  • Cause of death: excluded ICD-9 2632

2 out of 7 registries used, show all original rules.

247

4. Check minimum number of events

None

247

5. Include endpoints

None

247

6. Filter based on genotype QC (FinnGen only)

233

Control definitions (FinnGen only)

Control exclude
E4_MALNUTRITION

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E40-E46
Name in latin
Malnutritio moderata sive levis ex deficientia proteino-energetica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3200 1841 1349
Only index persons 2726 1607 1119
Unadjusted period prevalence (%)
Whole population 0.05 0.05 0.04
Only index persons 0.05 0.06 0.04
Median age at first event (years)
Whole population 65.21 68.83 60.28
Only index persons 68.06 71.33 63.35

-FinnGen-

Key figures

All Female Male
Number of individuals 233 125 108
Unadjusted period prevalence (%) 0.05 0.05 0.05
Median age at first event (years) 63.46 61.03 66.27

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
247
Matched controls
2469
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E44.0
ICD-10 Finland
Moderate protein-energy malnutrition
+∞
191.5
158
*
E44.1
ICD-10 Finland
Mild protein-energy malnutrition
+∞
99.9
89
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.8
20.6
79
221
R63.4
ICD-10 Finland
Abnormal weight loss
10.9
16.2
31
32
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
15.4
68
211
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
13.1
14.4
25
21
SPAT1262
SPAT
Handing over of treatment supplies
3.6
13.4
70
247
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
13.3
67
230
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.4
13.2
35
62
130
Kela drug reimbursment
Malignant tumour
5.1
13.2
43
98
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
17.0
12.4
19
12
A03FA01
ATC
metoclopramide; systemic, rectal
3.2
11.4
69
267
ZXE10
NOMESCO Finland
More than one and less than three hours
2.5
10.6
115
634
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
10.3
37
93
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
10.3
100
517
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
10.2
126
739
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
10.2
86
411
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.8
10.0
28
53
ZXD05
NOMESCO Finland
Urgent procedure
2.5
9.9
103
550
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.1
9.7
57
216
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
9.5
90
454
R53
ICD-10 Finland
Malaise and fatigue
2.7
9.4
75
342
602
Kela drug reimbursment
Children's severe malnutrition
14.4
9.3
15
11
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.3
9.1
49
173
S97
ICPC
Chronic ulcer skin
5.9
8.9
24
44
R4190
NOMESCO Finland
Nutritional therapy
4.5
8.8
31
77
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.1
8.6
33
89
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
34.6
8.1
10
*
ZXE00
NOMESCO Finland
One hour or less
2.2
8.1
121
753
JDB10
NOMESCO Finland
Percutaneous gastrostomy
11.3
7.9
14
13
AA1AD
NOMESCO Finland
CT of head and brain
2.5
7.9
72
353
SPAT1301
SPAT
No procedures
2.3
7.8
96
540
R50.9
ICD-10 Finland
Fever, unspecified
2.8
7.8
54
226
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
7.8
43
155
TJD20
NOMESCO Finland
Change of gastrostomy tube
19.1
7.7
11
6
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
7.6
37
122
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.8
7.6
32
94
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
5.9
7.6
20
36
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
7.5
94
533
JN3AD
NOMESCO Finland
Abdominal CT examination
4.3
7.5
27
69
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
7.3
112
694
A06AD11
ATC
lactulose; oral
2.8
7.3
49
201
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.3
7.2
26
66
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
12.5
7.2
12
10
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
7.2
41
152
T08
ICPC
Weight loss
10.5
7.1
13
13
N02AA05
ATC
oxycodone; systemic
2.7
7.1
50
210
SPAT1229
SPAT
Assessment of need for aid
3.6
7.0
31
95
A04
ICPC
Weakness/tiredness general
2.7
7.0
49
205
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.2
6.9
36
125
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
6.0
6.9
18
32
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.4
6.9
17
28
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
8.2
6.7
14
18
XX3DW
NOMESCO Finland
Time consuming IT work
3.5
6.7
30
93
N05AH03
ATC
olanzapine; systemic
4.8
6.7
21
47
F50.9
ICD-10 Finland
Eating disorder, unspecified
12.7
6.6
11
9
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.5
6.6
22
52
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.5
6.6
22
52
N05BA04
ATC
oxazepam; oral
2.2
6.5
71
377
RD210
NOMESCO Finland
NA
6.3
6.4
16
27
Z51.5
ICD-10 Finland
Palliative care
4.2
6.4
23
59
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
6.3
39
149
ZY010
NOMESCO Finland
Hospital outpatient
4.0
6.3
24
65
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
6.3
39
151
S42.0
ICD-10 Finland
Fracture of clavicle
6.0
6.3
16
28
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.2
6.2
22
56
A02BC02
ATC
pantoprazole; systemic
2.0
6.1
147
1060
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.4
6.1
28
89

Mortality – FinRegistry

Association

Association between endpoint E4_PROTMALMODMILD and mortality.

Females

Parameter HR [95% CI] p-value
E4_PROTMALMODMILD 3.147 [2.18, 4.54] < 0.001
Birth year 0.998 [0.99, 1.01] 0.571

During the follow-up period (1.1.1998 — 31.12.2019), 470 out of 1454 females with E4_PROTMALMODMILD died.

Males

Parameter HR [95% CI] p-value
E4_PROTMALMODMILD 5.396 [3.07, 9.48] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 388 out of 1064 males with E4_PROTMALMODMILD died.

Mortality risk

Mortality risk for people of age

years, who have E4_PROTMALMODMILD.

N-year risk Females Males
1 0.371% 1.062%
5 2.039% 5.903%
10 5.263% 14.741%
15 9.564% 25.784%
20 16.165% 39.597%

Relationships between endpoints

Index endpoint: E4_PROTMALMODMILD – Protein-energy malnutrition of moderate and mild degree

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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