protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.
Protein-energy malnutrition of moderate and mild degree
DOID EFO Endpoint Browser PheWeb
E4_PROTMALMODMILD
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
281 |
4. Check minimum number of eventsNone |
281 |
5. Include endpointsNone |
281 |
6. Filter based on genotype QC (FinnGen only) |
281 |
Control definitions (FinnGen only)
- Control exclude
- E4_MALNUTRITION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E40-E46
- Name in latin
- Malnutritio moderata sive levis ex deficientia proteino-energetica
Similar endpoints
↥List of similar endpoints to
Protein-energy malnutrition of moderate and mild degree
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3200 | 1841 | 1349 |
| Only index persons | 2726 | 1607 | 1119 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.21 | 68.83 | 60.28 |
| Only index persons | 68.06 | 71.33 | 63.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 281 | 156 | 125 |
| Unadjusted period prevalence (%) | 0.05 | 0.05 | 0.06 |
| Median age at first event (years) | 64.12 | 61.72 | 67.12 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 247
- Matched controls
- 2469
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E44.0
ICD-10 Finland
Moderate protein-energy malnutrition
+∞
191.5
158
*
E44.1
ICD-10 Finland
Mild protein-energy malnutrition
+∞
99.9
89
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.8
20.6
79
221
R63.4
ICD-10 Finland
Abnormal weight loss
10.9
16.2
31
32
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.1
15.4
68
211
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
13.1
14.4
25
21
SPAT1262
SPAT
Handing over of treatment supplies
3.6
13.4
70
247
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.6
13.3
67
230
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
6.4
13.2
35
62
130
Kela drug reimbursment
Malignant tumour
5.1
13.2
43
98
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
17.0
12.4
19
12
A03FA01
ATC
metoclopramide; systemic, rectal
3.2
11.4
69
267
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.5
10.3
37
93
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.6
10.3
100
517
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
10.2
126
739
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
10.2
86
411
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
5.8
10.0
28
53
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.1
9.7
57
216
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
9.5
90
454
R53
ICD-10 Finland
Malaise and fatigue
2.7
9.4
75
342
602
Kela drug reimbursment
Children's severe malnutrition
14.4
9.3
15
11
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.3
9.1
49
173
S97
ICPC
Chronic ulcer skin
5.9
8.9
24
44
R4190
NOMESCO Finland
Nutritional therapy
4.5
8.8
31
77
NE1AA
NOMESCO Finland
Pelvis X-ray examination
4.1
8.6
33
89
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
34.6
8.1
10
*
JDB10
NOMESCO Finland
Percutaneous gastrostomy
11.3
7.9
14
13
AA1AD
NOMESCO Finland
CT of head and brain
2.5
7.9
72
353
SPAT1301
SPAT
No procedures
2.3
7.8
96
540
R50.9
ICD-10 Finland
Fever, unspecified
2.8
7.8
54
226
TPH07
NOMESCO Finland
Cathetrisation of artery
3.1
7.8
43
155
TJD20
NOMESCO Finland
Change of gastrostomy tube
19.1
7.7
11
6
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.4
7.6
37
122
K08.1
ICD-10 Finland
Loss of teeth due to accident, extraction or local periodontal disease
3.8
7.6
32
94
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
5.9
7.6
20
36
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
7.5
94
533
JN3AD
NOMESCO Finland
Abdominal CT examination
4.3
7.5
27
69
SPAT1249
SPAT
Treatment-related counselling outside office
2.1
7.3
112
694
A06AD11
ATC
lactulose; oral
2.8
7.3
49
201
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.3
7.2
26
66
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
12.5
7.2
12
10
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.0
7.2
41
152
T08
ICPC
Weight loss
10.5
7.1
13
13
N02AA05
ATC
oxycodone; systemic
2.7
7.1
50
210
SPAT1229
SPAT
Assessment of need for aid
3.6
7.0
31
95
A04
ICPC
Weakness/tiredness general
2.7
7.0
49
205
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.2
6.9
36
125
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
6.0
6.9
18
32
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.4
6.9
17
28
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
8.2
6.7
14
18
XX3DW
NOMESCO Finland
Time consuming IT work
3.5
6.7
30
93
N05AH03
ATC
olanzapine; systemic
4.8
6.7
21
47
F50.9
ICD-10 Finland
Eating disorder, unspecified
12.7
6.6
11
9
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.5
6.6
22
52
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
4.5
6.6
22
52
N05BA04
ATC
oxazepam; oral
2.2
6.5
71
377
RD210
NOMESCO Finland
NA
6.3
6.4
16
27
Z51.5
ICD-10 Finland
Palliative care
4.2
6.4
23
59
D64.9
ICD-10 Finland
Anaemia, unspecified
2.9
6.3
39
149
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.9
6.3
39
151
S42.0
ICD-10 Finland
Fracture of clavicle
6.0
6.3
16
28
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.2
6.2
22
56
A02BC02
ATC
pantoprazole; systemic
2.0
6.1
147
1060
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.4
6.1
28
89
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
109
231
7.08
53.57
3.1
2.9
0.2
0.2
g/l
4.12
103
215
115
363
4.67
34.01
8.7
7.8
1.1
1.2
mmol/l
0.69
107
331
116
374
4.58
33.27
7.3
5.7
0.8
0.8
mmol/l
1.02
106
340
194
957
4.32
29.88
8.3
5.4
32.0
35.5
g/l
11.27
186
888
143
636
3.54
24.29
3.3
2.5
3.4
3.0
mg/l
0.79
128
542
36
55
7.36
23.16
5.2
3.8
5.1
5.0
kpa
0.14
36
55
33
51
7.20
20.96
3.8
2.9
15.6
15.9
%
0.14
13
28
109
454
3.29
19.82
3.0
1.7
1655.0
1210.9
nmol/l
3.12
81
335
172
939
3.14
19.42
3.6
2.7
71.8
76.5
nmol/l
1.34
164
827
199
1202
3.25
18.41
12.9
7.5
1.2
1.2
mmol/l
0.95
144
1009
90
347
3.34
18.40
2.8
2.8
2.2
2.4
g/l
1.07
84
315
187
1095
3.12
18.19
12.6
7.2
1.2
1.2
mmol/l
3.14
179
991
87
334
3.32
17.85
2.9
2.9
20.6
21.9
%
0.17
73
293
147
761
2.95
17.81
3.1
3.3
2.3
2.4
mmol/l
2.13
131
666
119
556
2.98
17.30
2.0
1.6
19.9
20.9
nmol/l
0.30
101
461
18
16
11.95
17.26
2.3
2.8
25.0
23.4
umol/l
0.19
18
16
106
469
3.02
16.94
2.6
1.8
434.3
17493916.4
pmol/l
0.50
86
383
92
381
3.10
16.46
3.0
2.8
11.2
12.9
umol/l
0.40
84
344
187
1134
2.94
16.35
8.6
6.4
12.5
11.9
umol/l
0.15
176
1073
69
241
3.47
16.34
8.6
3.9
—
—
—
0
0
27
45
6.53
15.90
2.1
1.8
—
—
—
0
0
169
982
2.81
15.86
4.0
3.0
284.9
115.4
ug/l
0.62
149
885
25
40
6.76
15.28
1.8
1.8
—
—
—
0
0
63
233
3.20
13.42
13.3
9.5
25.8
24.7
mmol/l
1.12
63
233
125
667
2.57
13.28
3.2
2.4
55.0
58.9
u/l
0.46
114
608
149
876
2.49
12.71
2.5
2.0
91.6
94.8
pmol/l
0.31
87
434
115
603
2.54
12.52
6.1
4.8
0.0
0.0
estimate
0.00
57
207
30
69
4.75
12.49
2.1
1.8
—
—
—
0
0
30
70
4.68
12.27
2.1
1.9
—
—
—
0
0
85
388
2.71
12.26
2.3
1.9
—
—
—
0
0
26
54
5.20
12.16
1.9
1.8
—
—
—
0
0
148
882
2.43
12.06
3.8
3.9
—
—
—
0
0
28
64
4.75
11.73
1.4
1.4
282.5
289.6
ug/g
0.05
17
39
17
24
7.48
11.55
1.6
1.4
—
—
—
0
0
20
34
6.26
11.49
2.3
2.4
32.3
32.5
pg
0.06
20
34
37
109
3.76
11.13
9.8
13.2
1.4
1.4
mg/l
0.13
32
99
31
81
4.18
10.99
2.8
1.9
4.8
5.7
ug/l
0.06
25
74
194
1344
2.43
10.73
9.8
5.4
6.7
6.7
mmol/l
0.00
185
1245
194
1360
2.38
10.20
11.1
9.5
4.6
4.0
e9/l
1.70
173
1192
44
156
3.16
9.92
8.9
10.1
9.4
9.3
kpa
0.11
36
142
15
22
7.15
9.83
1.9
1.6
—
—
—
0
0
26
65
4.31
9.74
3.0
3.0
42.1
32.4
mg/l
0.46
14
49
26
65
4.31
9.74
3.0
3.0
51.5
178.6
mg/l
0.64
14
49
221
1661
2.55
9.62
10.9
7.3
100.8
86.2
u/l
2.30
212
1545
55
228
2.76
9.36
11.8
10.9
8.7
8.8
mmol/l
0.03
55
216
57
241
2.71
9.34
8.8
8.1
5.1
5.1
kpa
0.08
52
221
18
34
5.59
9.29
1.8
1.7
—
—
—
0
0
114
662
2.21
9.24
3.3
2.2
132.8
247.0
u/l
2.39
101
623
25
64
4.19
9.08
2.6
2.3
—
—
—
0
0
205
1508
2.33
9.08
7.0
5.2
18.6
2493.8
e6/l
—
8
30
61
272
2.59
8.97
4.5
4.2
258.2
246.3
u/l
0.28
52
257
119
715
2.15
8.75
3.7
3.8
0.6
0.4
e6/l
0.40
105
545
54
230
2.67
8.69
8.7
8.3
1.1
1.7
mmol/l
0.30
40
157
11
13
8.77
8.52
1.7
1.3
—
—
—
0
0
20
45
4.71
8.51
1.8
1.6
—
—
—
0
0
20
46
4.60
8.29
3.1
3.5
57.7
57.4
%
0.02
20
46
150
1005
2.06
8.06
5.9
4.3
—
—
—
0
0
11
14
8.14
8.04
1.7
1.3
—
—
—
0
0
45
183
2.74
7.90
3.2
2.5
65.9
65.5
g/l
0.11
39
163
11
15
7.59
7.60
1.7
1.4
—
—
—
0
0
215
1667
2.23
7.58
5.6
3.9
15.5
14.9
pmol/l
1.57
194
1476
20
50
4.23
7.48
2.0
1.2
—
—
—
0
0
23
64
3.82
7.47
2.3
1.5
—
—
—
0
0
78
419
2.19
7.43
3.3
2.8
2.5
2.5
mmol/l
0.96
68
367
26
81
3.44
7.17
2.8
2.4
267.8
368.7
ug/l
0.43
19
74
130
856
1.97
7.06
6.2
4.2
67.6
43.6
ng/l
0.43
108
643
130
860
1.95
6.93
6.0
4.7
—
—
—
0
0
18
44
4.30
6.92
2.3
2.9
4.1
4.6
e9/l
0.36
18
44
174
1288
1.92
6.44
5.1
3.4
91.3
45.1
u/l
1.73
161
1194
39
164
2.60
6.38
3.4
3.5
57.8
62.9
ml/min/173m2
0.32
17
72
155
1116
1.87
6.14
6.4
6.1
0.0
0.0
estimate
0.00
65
210
14
31
4.70
6.05
1.6
1.7
—
—
—
0
0
39
170
2.50
5.93
2.2
1.7
—
—
—
0
0
154
1115
1.84
5.91
5.6
4.5
0.0
0.0
estimate
0.00
66
211
205
1629
1.96
5.82
5.4
4.4
17.0
12.1
mm/h
2.94
183
1477
155
1130
1.83
5.76
5.6
4.4
0.0
0.0
estimate
0.00
65
205
103
667
1.86
5.59
4.0
3.4
85.6
33.0
u/l
0.63
95
631
43
202
2.33
5.55
1.9
1.9
2.1
1.5
%
1.10
36
174
33
137
2.60
5.54
1.6
1.6
—
—
—
0
0
91
568
1.89
5.53
1.5
1.4
1.0
1.3
u/ml
0.39
28
131
14
34
4.28
5.42
1.6
1.7
—
—
—
0
0
54
285
2.11
5.25
2.4
1.9
—
—
—
0
0
54
286
2.10
5.20
2.3
1.9
—
—
—
0
0
27
107
2.69
4.96
1.4
1.9
1.4
1.6
g/l
0.50
19
95
12
28
4.43
4.87
4.4
2.9
—
—
—
0
0
12
29
4.28
4.67
4.3
2.8
7.9
8.6
%
—
7
21
7
5
14.30
4.60
1.3
1.6
—
—
—
0
0
56
315
1.97
4.56
10.8
5.9
2.1
1.7
mmol/l
0.45
42
243
22
82
2.83
4.53
1.6
1.4
—
—
—
0
0
40
200
2.17
4.45
3.4
5.7
75.1
75.6
ng/l
0.01
32
180
102
699
1.72
4.38
4.6
3.8
2321.2
1537.0
ng/l
0.99
85
588
232
1991
1.95
4.37
6.6
4.7
2.0
2.0
mu/l
0.24
217
1775
45
248
1.97
3.87
9.1
7.1
1.7
1.2
mmol/l
0.32
32
199
7
8
8.93
3.79
2.9
8.4
—
—
—
0
0
15
52
2.99
3.52
1.7
1.8
106.2
82.6
u/ml
—
6
9
250
2251
2.00
3.37
15.5
10.6
26.5
24.2
u/l
0.41
245
2165
15
55
2.82
3.21
1.7
1.8
—
—
—
0
0
244
2207
1.80
2.85
32.4
15.7
26.1
24.3
mg/l
0.45
220
1733
18
81
2.31
2.60
1.9
2.0
—
—
—
0
0
17
75
2.35
2.56
2.4
1.9
—
—
—
0
0
17
75
2.35
2.56
1.9
1.8
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
16
69
2.40
2.53
19.4
3.8
0.4
0.4
u/ml
—
10
37
7
19
3.75
2.16
1.9
1.3
121.4
282.7
u/l
—
7
19
14
63
2.29
2.04
2.4
2.0
—
—
—
0
0
33
203
1.71
2.03
2.8
2.8
4.4
8.0
ug/l
0.84
26
182
164
1406
1.40
2.03
2.8
3.2
—
—
—
0
0
40
260
1.63
2.01
5.5
3.8
18.2
7.2
umol/l
0.75
31
226
5
11
4.61
1.95
1.0
1.7
2.2
5.8
u/field
—
5
6
9
33
2.78
1.95
1.2
1.2
—
—
—
0
0
258
2426
1.78
1.90
45.1
22.7
4.1
4.4
e12/l
13.36
252
2335
6
17
3.58
1.84
1.7
1.2
—
—
—
0
0
6
17
3.58
1.84
2.8
1.3
—
—
—
0
0
5
12
4.22
1.83
1.0
1.0
—
—
—
0
0
5
12
4.22
1.83
2.2
1.9
30.2
58.2
ug/l
—
5
12
7
23
3.09
1.81
1.3
1.0
—
—
—
0
0
7
23
3.09
1.81
1.3
1.0
—
—
—
0
0
33
212
1.63
1.75
3.9
4.2
5.0
38.9
ug/l
0.56
28
181
5
13
3.89
1.72
1.2
1.1
—
—
u/ml
—
0
0
207
1872
1.40
1.71
29.1
14.7
82.2
78.6
ml/min/173m2
1.10
185
1501
10
42
2.43
1.69
1.2
1.4
—
—
—
0
0
29
182
1.66
1.68
10.7
7.8
24.0
24.4
mmol/l
0.42
29
176
8
31
2.63
1.67
2.8
1.9
—
—
—
0
0
65
493
1.41
1.60
3.3
2.0
1.9
1.4
mg/l
0.68
50
371
6
20
3.04
1.59
1.2
1.0
—
—
—
0
0
22
130
1.75
1.58
1.9
1.7
—
—
—
0
0
9
38
2.41
1.47
2.7
1.7
—
—
—
0
0
7
28
2.54
1.46
1.3
1.7
—
—
—
0
0
7
28
2.54
1.46
1.0
1.5
—
—
—
0
0
69
539
1.37
1.43
4.0
2.5
—
—
—
0
0
7
29
2.45
1.40
2.7
4.4
—
—
—
0
0
206
1887
1.34
1.38
35.6
19.2
14.3
13.7
%
5.42
201
1857
6
23
2.64
1.37
1.2
1.1
—
—
—
0
0
6
23
2.64
1.37
1.5
1.1
—
—
—
0
0
215
1988
1.35
1.31
26.4
16.8
38.0
38.9
%
1.15
108
1420
10
48
2.12
1.29
1.7
1.3
—
—
—
0
0
5
18
2.81
1.29
1.2
1.4
82.4
57.1
%
—
5
13
21
131
1.65
1.27
17.2
3.1
0.7
0.7
%
0.16
21
131
35
481
0.69
1.25
1.5
1.8
—
—
—
0
0
36
257
1.46
1.23
20.4
8.1
—
—
—
0
0
8
37
2.20
1.22
1.3
1.2
—
—
—
0
0
5
19
2.66
1.22
2.8
5.5
—
—
—
0
0
5
19
2.66
1.22
1.8
2.1
—
—
—
0
0
6
127
0.46
1.20
1.2
1.6
—
—
—
0
0
54
420
1.35
1.15
5.1
4.0
259.2
190.7
ng/l
0.17
41
336
21
136
1.59
1.12
17.2
3.1
1.3
1.1
%
0.84
21
136
5
22
2.29
1.04
2.0
1.7
—
—
—
0
0
10
53
1.92
1.02
1.1
1.4
—
—
—
0
0
39
296
1.37
0.98
25.5
26.7
1.4
1.3
inr
0.25
11
35
13
77
1.72
0.97
1.5
1.5
—
—
—
0
0
8
42
1.93
0.89
1.7
1.6
6859.5
105.6
u/ml
—
8
36
8
46
1.76
0.83
1.3
1.3
—
—
—
0
0
208
1962
1.23
0.79
4.7
4.6
5.9
6.0
mmol/l
0.16
181
1753
0
28
0.00
0.76
0.0
1.1
—
—
—
0
0
5
24
2.10
0.75
1.0
1.1
—
—
—
0
0
9
56
1.63
0.73
1.7
1.5
—
—
—
0
0
10
62
1.64
0.66
2.0
1.8
—
—
—
0
0
196
1855
1.19
0.64
6.6
6.0
39.6
40.2
mmol/mol
0.29
183
1700
18
130
1.41
0.63
1.4
2.1
12.6
12.8
nmol/l
0.03
11
109
35
418
0.81
0.50
3.3
3.6
3.0
2.2
e6/l
0.24
19
248
17
222
0.75
0.49
2.2
2.2
—
—
—
0
0
19
243
0.77
0.48
4.0
4.7
34.0
31.8
%
0.40
12
150
10
69
1.47
0.45
1.4
1.4
—
—
—
0
0
10
69
1.47
0.45
1.4
1.3
—
—
—
0
0
10
69
1.47
0.45
1.4
1.4
—
—
—
0
0
39
333
1.20
0.43
1.1
1.3
60.7
32.3
iu/ml
—
10
102
0
15
0.00
0.41
0.0
1.8
—
8.8
—
0
6
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
47
533
0.86
0.40
1.7
1.6
1.4
1.3
mmol/l
0.40
33
439
61
546
1.15
0.40
4.5
3.1
349.0
7866.3
umol/l
2.94
52
463
20
244
0.81
0.36
2.0
2.3
—
—
—
0
0
6
45
1.34
0.34
1.5
1.6
—
—
—
0
0
66
604
1.12
0.31
4.4
5.3
2.2
2.4
ug/l
0.13
53
533
40
449
0.87
0.30
3.1
3.2
1.3
1.0
e6/l
0.47
24
276
12
152
0.78
0.30
1.1
1.1
—
—
—
0
0
10
130
0.76
0.30
1.5
1.3
—
—
—
0
0
35
311
1.14
0.26
1.2
1.3
1.5
11.0
u/ml
2.43
12
125
9
72
1.26
0.26
1.6
1.1
—
—
—
0
0
9
77
1.17
0.24
2.0
1.4
—
0.0
—
0
17
7
91
0.76
0.23
1.7
1.2
—
—
—
0
0
5
42
1.19
0.21
1.2
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
13.7
—
0
10
0
10
0.00
0.21
0.0
1.2
—
430.6
—
0
5
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
2.2
—
—
—
0
0
5
43
1.17
0.21
1.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
6
52
1.16
0.19
2.0
1.4
—
—
—
0
0
6
52
1.16
0.19
2.0
1.4
—
—
—
0
0
6
52
1.16
0.19
2.0
1.4
—
—
—
0
0
26
289
0.89
0.18
1.3
1.4
—
—
—
0
0
16
138
1.17
0.18
1.3
1.3
42.7
141.7
iu/ml
—
8
46
12
140
0.85
0.15
1.8
2.1
—
—
—
0
0
196
1995
0.94
0.15
4.8
4.9
2.4
2.6
mmol/l
1.99
165
1797
7
90
0.77
0.14
1.7
1.2
—
—
—
0
0
10
84
1.20
0.14
1.6
1.9
—
—
—
0
0
58
608
0.94
0.12
5.0
4.0
15.3
38.2
mg/mmol
0.36
32
384
6
54
1.11
0.09
1.5
1.5
—
—
—
0
0
6
58
1.04
0.08
2.0
1.6
—
—
—
0
0
188
1857
1.04
0.08
4.3
4.0
1.2
1.2
mmol/l
0.99
156
1663
10
112
0.89
0.07
1.3
2.0
—
—
—
0
0
191
1929
0.97
0.06
4.5
4.4
1.5
1.5
mmol/l
0.52
162
1736
49
474
1.04
0.06
3.4
4.6
21.0
21.5
%
0.10
26
242
196
1946
1.02
0.04
4.5
4.4
4.3
4.5
mmol/l
1.20
166
1769
35
339
1.04
0.03
2.3
3.2
0.9
0.8
ug/l
0.10
22
238
11
105
1.05
0.00
1.8
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
259.2
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.0
—
118.8
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
24.4
—
0
5
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
8
0.00
0.00
0.0
1.0
—
138.8
—
0
8
0
8
0.00
0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
6
66
0.91
0.00
1.5
2.1
—
—
—
0
0
0
7
0.00
0.00
0.0
10.6
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PROTMALMODMILD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALMODMILD | 3.147 [2.18, 4.54] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.571 |
During the follow-up period (1.1.1998 — 31.12.2019), 470 out of 1454 females with E4_PROTMALMODMILD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALMODMILD | 5.396 [3.07, 9.48] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 388 out of 1064 males with E4_PROTMALMODMILD died.
Mortality risk
Mortality risk for people of age
years, who have E4_PROTMALMODMILD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.371% | 1.062% |
| 5 | 2.039% | 5.903% |
| 10 | 5.263% | 14.741% |
| 15 | 9.564% | 25.784% |
| 20 | 16.165% | 39.597% |
Relationships between endpoints
↥Index endpoint: E4_PROTMALMODMILD – Protein-energy malnutrition of moderate and mild degree
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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