protein energy malnutrition: A nutritional deficit that is caused by inadequate protein or calorie intake.
Protein-energy malnutrition of moderate and mild degree
DOID EFO Endpoint Browser PheWeb
E4_PROTMALMODMILD
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
324 |
4. Check minimum number of eventsNone |
324 |
5. Include endpointsNone |
324 |
6. Filter based on genotype QC (FinnGen only) |
307 |
Control definitions (FinnGen only)
- Control exclude
- E4_MALNUTRITION
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E40-E46
- Name in latin
- Malnutritio moderata sive levis ex deficientia proteino-energetica
Similar endpoints
↥List of similar endpoints to
Protein-energy malnutrition of moderate and mild degree
based on the number of shared cases.
Similar with more cases:
- Malnutrition
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3200 | 1841 | 1349 |
| Only index persons | 2726 | 1607 | 1119 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.05 | 0.06 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 65.21 | 68.83 | 60.28 |
| Only index persons | 68.06 | 71.33 | 63.35 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 307 | 172 | 135 |
| Unadjusted period prevalence (%) | 0.06 | 0.06 | 0.06 |
| Median age at first event (years) | 67.46 | 66.10 | 69.20 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 324
- Matched controls
- 3239
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E44.0
ICD-10 Finland
Moderate protein-energy malnutrition
+∞
261.1
214
*
E44.1
ICD-10 Finland
Mild protein-energy malnutrition
+∞
120.5
108
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.2
32.6
126
430
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
7.6
30.6
47
71
R63.4
ICD-10 Finland
Abnormal weight loss
8.1
28.7
41
57
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
11.7
28.2
30
28
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
4.0
25.9
93
296
ZXD05
NOMESCO Finland
Urgent procedure
3.0
20.3
143
676
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
20.3
98
373
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
4.4
19.8
55
143
SPAT1262
SPAT
Handing over of treatment supplies
3.3
18.6
91
347
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
4.8
17.2
42
98
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.7
16.7
149
781
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
18.4
15.9
24
14
E86
ICD-10 Finland
Volume depletion
7.0
14.7
23
35
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.9
14.4
82
337
SPAT1229
SPAT
Assessment of need for aid
3.6
13.9
50
155
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.5
13.9
127
660
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
13.8
122
624
JN3BD
NOMESCO Finland
Extensive abdominal CT
3.6
13.5
49
153
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
13.4
181
1116
NE1AA
NOMESCO Finland
Pelvis X-ray examination
3.5
13.4
51
164
ZXE00
NOMESCO Finland
One hour or less
2.4
13.3
159
929
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.6
13.2
47
145
SPAT1249
SPAT
Treatment-related counselling outside office
2.4
13.1
154
891
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
6.1
12.4
22
38
R53
ICD-10 Finland
Malaise and fatigue
2.4
12.4
114
589
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
12.4
145
833
NF1AA
NOMESCO Finland
Hip X-ray examination
3.4
12.3
49
162
R4190
NOMESCO Finland
Nutritional therapy
4.0
12.3
37
101
130
Kela drug reimbursment
Malignant tumour
3.3
12.3
50
168
Z51.5
ICD-10 Finland
Palliative care
3.5
11.9
45
144
OAB73
NOMESCO Finland
Prevention and treatment of malnutrition
17.2
11.8
18
11
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
4.2
11.6
32
82
JN4AD
NOMESCO Finland
Body CT examination
3.3
11.5
47
158
N02AA05
ATC
oxycodone; systemic
2.6
11.5
86
402
SPAT1301
SPAT
No procedures
2.3
11.5
132
748
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
3.6
11.2
39
118
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
5.3
11.2
23
46
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
5.7
11.0
21
39
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.7
10.9
65
271
TPH07
NOMESCO Finland
Cathetrisation of artery
2.9
10.8
58
228
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
10.8
137
804
S72.0
ICD-10 Finland
Fracture of neck of femur
4.1
10.5
30
79
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
4.8
10.4
24
53
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.9
10.2
31
85
EBA15
NOMESCO Finland
Extraction of multiple teeth
4.6
10.2
25
58
R4180
NOMESCO Finland
Podiatric therapy
11.8
10.2
18
16
B03BA03
ATC
hydroxocobalamin; parenteral
3.6
9.9
34
102
S97
ICPC
Chronic ulcer skin
3.4
9.6
36
114
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
9.6
63
275
I95.1
ICD-10 Finland
Orthostatic hypotension
4.2
9.5
26
66
NB1BA
NOMESCO Finland
Shoulder extensive X-ray examination without contrast
4.7
9.4
22
49
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.8
9.4
51
201
602
Kela drug reimbursment
Children's severe malnutrition
9.1
9.4
19
22
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
9.4
45
166
M81.9
ICD-10 Finland
Osteoporosis, unspecified
3.9
9.4
28
76
A03FA01
ATC
metoclopramide; systemic, rectal
2.3
9.4
85
430
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
5.2
9.2
19
38
AA1AD
NOMESCO Finland
CT of head and brain
2.2
9.1
109
616
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.7
9.0
21
47
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.6
8.9
60
264
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
9.0
8.9
18
21
A02BC02
ATC
pantoprazole; systemic
2.1
8.8
214
1564
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
8.8
53
221
ZY010
NOMESCO Finland
Hospital outpatient
3.6
8.7
29
85
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.8
8.7
20
44
SPAT1310
SPAT
Counselling related to known health issue
2.1
8.6
124
750
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
8.6
54
230
R50.9
ICD-10 Finland
Fever, unspecified
2.3
8.3
71
349
SPAT1312
SPAT
General health counselling
2.0
8.2
125
768
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.4
8.0
30
95
SPAT1263
SPAT
Sampling
2.0
7.9
152
1009
JN3AD
NOMESCO Finland
Abdominal CT examination
2.7
7.8
46
190
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.4
7.7
29
92
WX302
NOMESCO Finland
Thoracal epidural anesthesy
3.7
7.6
24
68
S01.0
ICD-10 Finland
Open wound of scalp
2.9
7.5
38
144
SHA03
NOMESCO Finland
Stomatognathic treatment, demanding
4.6
7.5
18
41
TJD20
NOMESCO Finland
Change of gastrostomy tube
13.8
7.4
12
9
SPAT1153
SPAT
Removal of sutures
2.0
7.4
109
658
WZC00
NOMESCO Finland
Treatment plan or consultation
1.9
7.4
126
800
RD210, ,
NOMESCO Finland
4.3
7.4
19
46
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
7.4
33
117
R11
ICD-10 Finland
Nausea and vomiting
2.6
7.4
46
195
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.3
7.3
65
323
E42
ICD-10 Finland
Marasmic kwashiorkor
+∞
7.3
7
*
N05AX08
ATC
risperidone; systemic
2.6
7.3
43
177
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.6
7.3
24
70
A04
ICPC
Weakness/tiredness general
2.2
7.2
66
332
E87.6
ICD-10 Finland
Hypokalaemia
3.9
7.2
21
56
XX3DW
NOMESCO Finland
Time consuming IT work
2.6
7.2
45
191
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
3.1
7.2
30
102
N05BA04
ATC
oxazepam; oral
2.0
7.2
93
536
JDB10
NOMESCO Finland
Percutaneous gastrostomy
9.1
7.1
14
16
OAB74
NOMESCO Finland
Nutritional guidance related to treatment and rehabilitation for medical condition
10.4
7.1
13
13
TGC00
NOMESCO Finland
Bronchial lavation
4.5
7.0
17
39
-44
ICPC
Preventive immunization/medic
2.7
7.0
39
156
U04
ICPC
Incontinence urine
3.2
6.8
28
94
OAB50, ,
SPAT
3.3
6.7
25
79
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
4.2
6.7
18
45
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.1
6.7
29
101
GD1AD
NOMESCO Finland
Thorax CT examination
3.2
6.6
26
85
R1250, ,
SPAT
7.1
6.6
15
22
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
2.5
6.5
42
181
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.8
6.5
32
120
SPAT1053
SPAT
Memory test
2.2
6.4
63
325
JDD00
NOMESCO Finland
Total gastrectomy and Roux-en-Y oesophagojejunostomy
71.2
6.4
7
*
M80.0
ICD-10 Finland
Postmenopausal osteoporosis with pathological fracture
5.4
6.4
18
35
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
6.4
55
269
Z2445
NOMESCO Finland
Psychologist
3.2
6.4
26
87
SPAT1234
SPAT
Support of social functional capacity
3.0
6.4
28
98
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.8
6.4
33
127
JCA55
NOMESCO Finland
Endoscopic dilatation of oesophagus
11.3
6.3
11
10
C03CA01
ATC
furosemide; systemic
1.8
6.3
125
824
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.0
6.2
27
94
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
2.8
6.2
32
123
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.5
6.2
41
179
R41.0
ICD-10 Finland
Disorientation, unspecified
3.7
6.1
19
53
F50.9
ICD-10 Finland
Eating disorder, unspecified
8.8
6.1
12
14
L30.3
ICD-10 Finland
Infective dermatitis
5.4
6.1
17
33
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
5.7
6.1
16
29
E03.89
ICD-10 Finland
Other specified hypothyroidism
4.0
6.1
17
44
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.4
6.0
41
181
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
137
270
8.06
73.48
3.1
2.8
0.17
0.21
g/l
6.47
130
252
143
431
5.15
45.74
8.3
5.5
0.80
0.81
mmol/l
0.37
133
396
136
418
4.88
41.92
9.4
7.2
1.09
1.14
mmol/l
0.75
127
382
47
59
9.15
35.91
5.0
3.7
5.02
4.95
kpa
0.20
47
59
228
1134
4.41
34.74
8.1
5.2
31.64
35.43
g/l
14.45
218
1053
87
224
4.94
32.55
7.0
4.1
1.20
1.23
mmol/l
3.79
82
198
43
56
8.70
31.80
3.7
2.9
15.69
15.88
%
0.08
19
31
169
741
3.68
29.67
3.2
2.5
3.42
2.99
mg/l
1.06
150
631
92
278
4.22
27.66
8.3
3.7
—
—
—
0
0
151
642
3.53
27.32
2.0
1.6
20.06
20.57
nmol/l
0.15
130
537
111
398
3.72
25.96
2.9
2.7
20.49
21.74
%
0.22
95
349
145
619
3.43
25.77
3.3
3.0
5.97
4.90
e6/l
0.68
137
554
206
1088
3.45
25.72
3.6
2.7
71.00
76.36
nmol/l
1.94
197
958
34
43
8.71
25.61
1.7
1.7
—
—
—
0
0
113
415
3.64
25.41
2.9
2.7
2.19
2.35
g/l
1.50
105
376
35
49
7.88
24.22
1.9
1.7
—
—
—
0
0
104
373
3.63
24.10
3.4
4.1
1.81
1.74
%
0.25
88
337
224
1280
3.43
23.85
13.4
7.1
1.20
1.22
mmol/l
4.19
214
1163
235
1400
3.47
22.97
13.0
7.5
1.21
1.22
mmol/l
1.37
166
1195
115
453
3.38
22.83
3.2
2.7
10.89
12.81
umol/l
0.60
106
416
175
889
3.10
22.37
3.1
3.2
2.32
2.36
mmol/l
3.56
159
790
130
558
3.22
22.30
2.5
1.8
431.19
14597392.10
pmol/l
0.50
101
459
128
549
3.20
21.92
3.0
1.7
1624.58
1206.16
nmol/l
3.45
93
406
224
1331
3.21
21.29
8.3
6.3
13.10
12.07
umol/l
0.28
213
1262
35
58
6.64
20.75
1.7
1.8
—
—
—
0
0
199
1136
2.95
19.78
4.0
3.0
271.34
117.30
ug/l
0.67
174
1028
39
76
5.70
19.63
1.9
1.8
—
—
—
0
0
78
264
3.57
19.36
16.5
10.3
25.59
24.71
mmol/l
1.02
78
264
39
77
5.62
19.35
1.9
1.8
—
—
—
0
0
27
37
7.87
18.94
2.2
2.3
32.48
32.30
pg
0.06
27
37
144
707
2.87
18.79
6.1
4.8
0.00
0.00
estimate
-0.00
75
229
42
92
5.09
18.56
2.4
1.8
3.57
5.56
ug/l
0.20
36
80
165
885
2.76
17.95
3.6
3.9
122.51
129.74
e6/l
0.03
148
694
182
1037
2.72
17.39
2.5
2.0
88.91
94.11
pmol/l
0.71
110
518
204
1233
2.77
17.29
21.4
16.1
1.27
1.31
inr
0.39
114
357
181
1032
2.71
17.22
3.8
3.8
—
—
—
0
0
105
467
2.85
16.09
2.3
1.9
—
—
—
0
0
147
778
2.63
15.95
3.2
2.4
54.44
64.48
u/l
0.84
133
715
235
1564
2.83
15.85
10.0
5.4
6.61
6.65
mmol/l
0.09
226
1457
45
119
4.23
15.72
11.0
12.8
1.37
1.45
mg/l
0.29
39
109
80
313
3.06
15.40
4.3
4.1
250.20
245.13
u/l
0.13
70
297
34
73
5.08
15.31
2.6
2.8
42.07
31.03
mg/l
0.59
15
56
34
73
5.08
15.31
2.6
2.8
52.59
159.65
mg/l
0.61
15
56
171
1013
2.46
14.11
4.2
4.6
184.94
111.95
e6/l
0.41
150
737
148
823
2.47
14.03
3.7
3.7
0.50
0.42
e6/l
0.23
132
627
53
174
3.44
13.53
9.9
9.7
9.07
9.18
kpa
0.14
48
164
26
49
5.68
13.47
3.4
3.4
56.69
57.86
%
0.12
26
49
229
1571
2.56
13.37
11.5
9.6
4.59
4.05
e9/l
2.15
206
1366
167
998
2.39
13.27
6.2
4.2
59.33
73.09
ng/l
0.15
144
762
32
76
4.56
12.76
1.4
1.5
263.41
281.68
ug/g
0.16
19
49
23
41
5.96
12.60
1.7
1.6
—
—
—
0
0
261
1933
2.80
12.56
10.8
7.2
100.92
85.99
u/l
2.64
252
1802
139
783
2.36
12.45
3.2
2.2
130.43
230.64
u/l
2.54
124
740
28
61
4.93
12.37
2.0
1.3
—
—
—
0
0
59
219
3.07
12.27
3.0
2.5
65.22
65.75
g/l
0.16
53
197
24
26
9.87
12.21
1.5
1.4
—
—
—
0
0
24
47
5.43
11.92
2.8
2.8
4.47
4.58
e9/l
0.06
24
47
66
265
2.87
11.92
9.2
8.0
1.58
1.66
mmol/l
0.04
49
187
242
1761
2.48
11.50
6.9
5.2
16.30
3503.20
e6/l
—
10
35
25
53
5.03
11.38
1.7
1.6
—
—
—
0
0
256
1922
2.58
11.18
5.4
3.9
15.57
14.93
pmol/l
2.37
231
1704
197
1330
2.23
10.94
8.6
7.0
25.83
29.24
%
2.58
187
1255
64
265
2.76
10.86
12.3
9.9
8.38
8.80
mmol/l
0.21
64
250
97
497
2.36
10.51
3.2
2.9
2.48
2.46
mmol/l
1.00
86
439
30
79
4.08
10.47
2.7
2.6
—
—
—
0
0
159
1000
2.16
10.40
6.0
4.7
—
—
—
0
0
29
75
4.15
10.36
2.2
1.5
—
—
—
0
0
189
1295
2.10
9.61
6.3
6.0
0.00
0.00
estimate
-0.00
84
233
18
19
9.96
9.39
2.3
2.5
25.01
23.74
umol/l
0.14
18
19
189
1308
2.07
9.20
5.6
4.4
0.00
0.00
estimate
-0.00
83
229
173
1164
2.04
9.05
3.6
2.8
—
—
—
0
0
187
1296
2.05
8.99
5.6
4.4
0.00
0.00
estimate
-0.00
84
253
71
338
2.41
8.94
2.2
1.9
—
—
—
0
0
71
339
2.40
8.88
2.2
1.9
—
—
—
0
0
188
1309
2.04
8.88
8.3
6.7
57.48
55.82
%
0.72
176
1233
19
40
4.98
8.70
1.5
1.6
—
—
—
0
0
15
14
11.17
8.38
1.5
1.3
—
—
—
0
0
15
15
10.42
8.11
1.5
1.3
—
—
—
0
0
110
649
2.05
8.08
1.5
1.4
0.97
1.83
u/ml
1.13
35
157
42
162
2.83
8.06
1.6
1.5
—
—
—
0
0
202
1472
1.99
8.06
5.2
3.4
88.59
45.07
u/l
1.93
187
1363
241
1879
2.10
7.83
5.6
4.4
17.20
12.33
mm/h
3.39
216
1708
15
17
9.19
7.62
1.5
1.4
—
—
—
0
0
29
93
3.33
7.61
2.8
2.4
265.27
366.33
ug/l
0.50
22
85
122
767
1.95
7.36
4.0
3.3
77.09
32.65
u/l
0.62
112
728
46
201
2.50
6.90
2.1
1.8
—
—
—
0
0
43
183
2.56
6.81
3.2
3.3
57.74
63.35
ml/min/173m2
0.39
19
78
273
2296
2.20
6.36
6.4
4.7
2.02
1.99
mu/l
0.12
255
2061
18
36
5.23
6.28
1.5
1.6
—
—
—
0
0
125
826
1.83
6.26
4.8
3.6
2226.68
1484.61
ng/l
1.22
106
704
48
224
2.34
6.23
1.9
1.8
2.08
1.56
%
0.93
39
192
27
97
2.94
5.89
1.5
1.4
—
—
—
0
0
15
27
5.77
5.75
1.7
1.5
—
—
—
0
0
64
364
1.94
4.98
12.0
5.8
2.56
1.71
mmol/l
1.00
50
287
293
2604
2.30
4.85
15.8
10.7
27.31
23.95
u/l
0.72
286
2504
46
235
2.12
4.79
3.8
5.3
76.56
75.77
ng/l
0.02
36
209
53
290
1.99
4.59
11.2
7.2
1.66
1.19
mmol/l
0.35
38
231
8
8
10.21
4.54
2.9
8.3
—
—
—
0
0
287
2549
2.10
4.45
32.7
15.9
26.61
24.71
mg/l
0.53
262
2017
14
33
4.38
4.37
4.2
2.8
—
—
—
0
0
29
127
2.41
4.34
1.4
2.1
1.40
1.59
g/l
0.49
21
112
7
7
10.18
4.03
1.3
1.4
—
—
—
0
0
11
23
4.91
3.90
1.8
1.3
276.55
260.32
u/l
0.04
11
23
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
78
2.67
3.79
25.4
3.6
0.40
0.35
u/ml
0.29
14
44
7
8
8.91
3.79
2.1
2.6
57428.57
35525.63
ug/l
—
7
8
6
5
12.18
3.77
1.3
1.4
—
—
—
0
0
14
39
3.70
3.74
2.6
2.0
—
—
—
0
0
14
39
3.70
3.74
2.6
2.0
—
—
—
0
0
15
50
3.10
3.73
2.5
2.0
—
—
—
0
0
15
50
3.10
3.73
2.5
2.0
—
—
—
0
0
21
86
2.54
3.63
2.1
1.9
—
—
—
0
0
193
1582
1.54
3.54
2.9
3.2
—
—
—
0
0
16
62
2.66
3.09
1.7
1.7
106.17
89.15
u/ml
—
6
11
247
2170
1.58
3.06
29.3
15.0
81.57
77.70
ml/min/173m2
1.53
223
1743
301
2794
2.08
3.00
46.0
23.1
256.10
249.48
e9/l
0.74
296
2703
301
2796
2.07
2.96
47.3
23.2
37.28
39.33
%
9.09
286
2632
301
2797
2.07
2.94
46.1
23.0
4.12
4.43
e12/l
15.96
294
2694
16
64
2.58
2.91
1.7
1.7
—
—
—
0
0
48
302
1.69
2.67
5.6
3.6
16.38
7.11
umol/l
0.76
37
266
5
7
7.23
2.55
1.0
5.1
—
—
—
0
0
9
26
3.53
2.50
1.1
1.1
—
—
—
0
0
30
168
1.87
2.46
1.8
1.8
—
—
—
0
0
35
208
1.76
2.38
12.4
7.7
24.41
24.49
mmol/l
0.07
35
201
5
8
6.32
2.38
1.2
1.5
—
—
—
0
0
5
8
6.32
2.38
1.2
1.1
—
—
%
—
0
0
7
17
4.18
2.37
1.1
1.1
—
—
u/ml
—
0
0
16
72
2.28
2.31
2.4
1.9
—
—
—
0
0
7
18
3.95
2.26
2.6
2.1
—
—
—
0
0
19
93
2.11
2.26
1.9
1.8
—
—
—
0
0
9
29
3.16
2.24
1.2
1.0
—
—
—
0
0
9
29
3.16
2.24
1.2
1.0
—
—
—
0
0
13
54
2.47
2.22
1.5
1.3
—
—
—
0
0
5
9
5.62
2.22
4.4
3.9
—
—
—
0
0
12
48
2.56
2.21
1.3
1.4
—
—
—
0
0
8
24
3.39
2.19
1.1
1.0
—
—
—
0
0
20
102
2.02
2.15
1.9
1.9
—
—
—
0
0
14
62
2.31
2.10
1.4
1.4
—
—
—
0
0
250
2268
1.45
2.06
4.8
4.7
5.90
5.98
mmol/l
0.18
211
2029
7
20
3.55
2.06
1.1
1.1
—
—
—
0
0
238
2144
1.41
2.01
6.2
6.2
39.35
40.33
mmol/mol
0.67
218
1969
15
71
2.17
1.95
2.5
1.9
349.40
243.78
u/ml
—
5
32
6
16
3.80
1.94
1.0
1.0
—
—
—
0
0
75
564
1.43
1.89
4.2
2.0
1.76
1.41
mg/l
0.57
58
426
13
59
2.25
1.86
2.1
2.4
219.40
78.44
ug/min
—
6
41
44
298
1.55
1.85
18.6
8.1
—
—
—
0
0
5
12
4.21
1.83
1.0
1.7
2.20
5.14
u/field
—
5
7
9
35
2.61
1.81
2.6
1.8
—
—
—
0
0
8
29
2.80
1.80
1.0
1.5
—
—
—
0
0
6
18
3.37
1.75
1.7
1.2
—
—
—
0
0
25
149
1.73
1.72
15.0
3.8
0.68
0.68
%
0.00
25
149
5
13
3.89
1.72
2.0
1.8
69.00
62.77
umol/l
—
5
13
39
264
1.54
1.65
3.5
4.1
7.55
49.60
ug/l
0.79
33
221
10
42
2.42
1.63
2.5
1.6
—
—
—
0
0
12
56
2.19
1.63
1.2
1.3
—
—
—
0
0
36
243
1.54
1.55
2.9
2.7
4.10
7.67
ug/l
1.01
29
217
25
154
1.67
1.55
15.0
3.8
1.31
1.11
%
0.88
25
154
5
15
3.37
1.53
2.2
2.1
30.18
84.73
ug/l
—
5
15
7
27
2.63
1.52
1.0
1.1
—
—
—
0
0
9
37
2.47
1.49
1.2
1.2
—
—
—
0
0
79
631
1.33
1.38
4.3
2.5
—
—
—
0
0
14
76
1.88
1.32
1.4
1.4
—
—
—
0
0
39
532
0.70
1.31
1.8
1.7
—
—
—
0
0
7
144
0.47
1.23
1.1
1.6
—
—
—
0
0
16
93
1.76
1.23
1.6
1.5
—
—
—
0
0
76
616
1.30
1.19
4.1
3.0
346.89
7717.57
umol/l
3.18
64
519
22
142
1.59
1.17
1.4
2.1
10.79
12.64
nmol/l
0.37
14
124
8
40
2.02
1.13
1.3
1.2
—
—
—
0
0
50
385
1.35
1.11
1.2
1.3
91.95
36.54
iu/ml
0.56
14
116
7
31
2.28
1.11
1.4
1.1
—
—
—
0
0
7
31
2.28
1.11
1.3
1.7
—
—
—
0
0
7
31
2.28
1.11
2.7
4.7
—
—
—
0
0
13
74
1.79
1.08
1.5
1.4
—
—
—
0
0
5
22
2.29
1.03
2.8
5.6
—
—
—
0
0
5
23
2.19
0.98
4.6
2.7
—
—
—
0
0
5
23
2.19
0.98
2.0
1.7
—
—
—
0
0
5
23
2.19
0.98
1.8
2.1
—
—
—
0
0
229
2151
1.22
0.87
4.4
4.0
1.14
1.23
mmol/l
1.54
183
1934
13
80
1.65
0.86
1.5
1.1
—
—
—
0
0
0
28
0.00
0.76
0.0
1.1
—
—
—
0
0
12
76
1.60
0.72
1.4
1.3
—
—
—
0
0
12
76
1.60
0.72
1.4
1.3
—
—
—
0
0
237
2256
1.19
0.67
4.6
4.5
4.25
4.48
mmol/l
2.65
199
2063
5
28
1.80
0.66
2.0
2.1
—
—
—
0
0
59
505
1.21
0.60
5.7
4.1
294.93
209.54
ng/l
0.23
46
409
12
173
0.68
0.59
1.1
1.1
—
—
—
0
0
12
84
1.44
0.50
1.3
2.1
1.00
0.56
g/l
—
5
75
42
356
1.21
0.49
1.3
1.3
1.40
11.19
u/ml
2.79
17
136
23
287
0.79
0.48
3.7
4.8
35.13
32.20
%
0.67
15
183
28
339
0.81
0.46
1.4
1.4
—
—
—
0
0
10
69
1.46
0.44
2.0
1.7
—
—
—
0
0
232
2237
1.13
0.42
4.6
4.4
1.50
1.47
mmol/l
0.39
195
2023
5
32
1.57
0.42
2.2
1.7
0.19
0.26
nmol/l
—
5
25
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.8
—
8.34
—
0
17
77
698
1.13
0.40
4.6
5.4
2.71
2.40
ug/l
0.21
61
612
42
482
0.85
0.40
3.1
3.6
2.57
2.43
e6/l
0.05
24
276
0
18
0.00
0.40
0.0
1.2
—
—
—
0
0
12
89
1.36
0.38
1.7
1.4
—
0.05
—
0
23
16
125
1.29
0.37
1.6
2.7
25.25
45.15
u/ml
0.99
16
120
6
41
1.47
0.36
1.0
1.1
—
—
—
0
0
6
42
1.44
0.35
1.2
1.2
—
1.46
u/ml
—
0
13
11
144
0.76
0.34
1.5
1.3
—
—
—
0
0
6
47
1.28
0.32
1.8
1.3
—
—
—
0
0
7
53
1.33
0.31
1.4
1.5
—
—
—
0
0
7
56
1.26
0.29
1.4
1.4
—
—
—
0
0
19
159
1.21
0.27
1.3
1.3
38.61
131.15
iu/ml
—
9
55
237
2315
1.09
0.25
4.9
5.0
2.37
2.62
mmol/l
3.89
198
2096
0
11
0.00
0.21
0.0
2.0
—
13.70
—
0
11
0
11
0.00
0.21
0.0
1.2
—
430.60
—
0
5
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
11
0.00
0.21
0.0
1.1
—
137.91
—
0
11
0
10
0.00
0.21
0.0
1.8
—
27.86
—
0
10
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
8
103
0.77
0.21
1.6
1.2
—
—
—
0
0
8
103
0.77
0.21
1.6
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
6
77
0.77
0.16
1.5
1.9
—
—
—
0
0
21
234
0.89
0.15
2.0
2.2
—
—
—
0
0
65
616
1.07
0.15
1.8
1.6
1.26
1.30
mmol/l
0.15
44
509
13
150
0.86
0.15
1.7
2.1
—
—
—
0
0
41
385
1.07
0.12
2.5
3.2
0.88
0.80
ug/l
0.21
27
267
57
545
1.06
0.11
3.4
4.8
20.39
20.76
%
0.08
32
284
5
44
1.14
0.10
2.4
1.7
—
—
—
0
0
24
258
0.92
0.09
1.9
2.3
—
—
—
0
0
5
46
1.09
0.09
1.2
1.2
—
—
—
0
0
6
55
1.09
0.09
2.0
1.4
—
—
—
0
0
6
55
1.09
0.09
2.0
1.4
—
—
—
0
0
6
55
1.09
0.09
2.0
1.4
—
—
—
0
0
76
737
1.04
0.08
3.9
3.8
20.88
33.15
mg/mmol
0.20
39
461
11
98
1.13
0.07
1.5
1.9
—
—
—
0
0
12
108
1.12
0.07
1.8
1.5
—
—
—
0
0
11
119
0.92
0.04
1.3
2.0
—
—
—
0
0
50
511
0.97
0.03
2.9
3.2
1.36
0.99
e6/l
0.60
32
304
6
61
0.98
0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
259.20
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
22.33
—
0
6
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.6
—
—
—
0
0
5
56
0.89
-0.00
1.4
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
-0.00
1.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint E4_PROTMALMODMILD and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALMODMILD | 3.147 [2.18, 4.54] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.571 |
During the follow-up period (1.1.1998 — 31.12.2019), 470 out of 1454 females with E4_PROTMALMODMILD died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_PROTMALMODMILD | 5.396 [3.07, 9.48] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 388 out of 1064 males with E4_PROTMALMODMILD died.
Mortality risk
Mortality risk for people of age
years, who have E4_PROTMALMODMILD.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.371% | 1.062% |
| 5 | 2.039% | 5.903% |
| 10 | 5.263% | 14.741% |
| 15 | 9.564% | 25.784% |
| 20 | 16.165% | 39.597% |
Relationships between endpoints
↥Index endpoint: E4_PROTMALMODMILD – Protein-energy malnutrition of moderate and mild degree
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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