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Degeneration of the brain due to alcohol

EFO MESH Endpoint Browser PheWeb

G6_ALCODEGEN

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G31.2
  • Cause of death: ICD-10 — G31.2

2 out of 7 registries used, show all original rules.

778

4. Check minimum number of events

None

778

5. Include endpoints

None

778

6. Filter based on genotype QC (FinnGen only)

778

Control definitions (FinnGen only)

Control exclude
G6_NEURODEG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G31
Name in latin
Degeneratio systematis nervosi ex alcohol (aethylico)

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 12921 2765 9998
Only index persons 10336 2353 7983
Unadjusted period prevalence (%)
Whole population 0.24 0.08 0.28
Only index persons 0.26 0.09 0.30
Median age at first event (years)
Whole population 58.75 58.87 58.62
Only index persons 58.94 59.19 58.87

-FinnGen-

Key figures

All Female Male
Number of individuals 778 127 651
Unadjusted period prevalence (%) 0.25 0.04 0.29
Median age at first event (years) 59.68 57.78 60.05

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
721
Matched controls
7209
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
+∞
323.0
721
*
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
32.8
290.9
409
277
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
31.7
143.3
193
82
F10.25
ICD-10 Finland
Alcohol dependence continuous use
30.7
110.9
150
61
F10.20
ICD-10 Finland
Alcohol dependence currently independent
29.3
110.9
152
65
P15
ICPC
Chronic alcohol abuse
23.8
104.1
152
80
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
38.3
93.3
119
37
R56.8
ICD-10 Finland
Other and unspecified convulsions
13.4
90.9
167
158
N07BB01
ATC
disulfiram; oral
12.4
88.5
169
173
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
5.0
85.1
380
1308
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
25.7
75.0
106
48
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
22.5
73.2
108
56
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
50.5
70.8
85
19
F10.9
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Unspecified mental and behavioural disorder
37.9
70.6
90
27
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
23.2
68.0
99
49
N05AH04
ATC
quetiapine; oral
5.7
67.9
227
537
AA1AD
NOMESCO Finland
CT of head and brain
4.4
66.2
314
1075
F10.24
ICD-10 Finland
Alcohol depence active use
25.6
65.1
92
41
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
24.6
65.1
93
43
N05BA02
ATC
chlordiazepoxide; systemic
14.2
62.7
110
90
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
39.6
61.9
78
22
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
31.3
57.1
76
27
G62.1
ICD-10 Finland
Alcoholic polyneuropathy
91.7
53.8
59
7
F10.2
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Dependence syndrome
25.6
52.6
74
32
S01.0
ICD-10 Finland
Open wound of scalp
6.5
52.1
147
272
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
16.2
51.0
84
58
N06AX11
ATC
mirtazapine; oral
3.5
50.2
319
1325
N06AB04
ATC
citalopram; systemic
4.0
49.9
242
803
F10.09
ICD-10 Finland
Alcohol intoxication UNS
14.4
49.7
86
67
P16
ICPC
Acute alcohol abuse
20.7
48.6
73
39
N05CD07
ATC
temazepam; oral
4.4
45.0
188
535
F10.30
ICD-10 Finland
Withdrawal symptoms caused by alcohol uncomplicated
19.6
44.6
68
38
C07AA05
ATC
propranolol; systemic
4.2
44.5
200
610
N05BA04
ATC
oxazepam; oral
3.6
44.3
256
966
K70.1
ICD-10 Finland
Alcoholic hepatitis
37.1
43.2
55
16
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.8
42.3
216
733
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
10.2
42.2
86
94
N05BA01
ATC
diazepam; systemic, rectal
4.2
41.8
180
524
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.3
41.4
279
1168
K92.0
ICD-10 Finland
Haematemesis
11.5
39.3
75
72
F32.9
ICD-10 Finland
Depressive episode, unspecified
5.2
39.0
133
303
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.6
38.9
88
115
N05CF01
ATC
zopiclone; oral
3.0
38.8
319
1517
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
10.9
37.7
74
75
A28
ICPC
Limited function/disability NOS
3.8
36.8
179
574
F05.9
ICD-10 Finland
Delirium, unspecified
14.6
36.5
62
46
A06AD11
ATC
lactulose; oral
3.7
36.1
180
588
Z72.1
ICD-10 Finland
Alcohol use
16.2
35.0
57
38
R53
ICD-10 Finland
Malaise and fatigue
3.5
35.0
196
701
L28
ICPC
Limited function/disability (L)
3.7
34.3
171
556
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
11.2
33.8
65
63
S06.0
ICD-10 Finland
Concussion
4.4
32.8
129
338
W19
ICD-10 Finland
Unspecified fall
4.5
32.5
126
325
E87.6
ICD-10 Finland
Hypokalaemia
11.2
32.3
62
60
F03
ICD-10 Finland
Unspecified dementia
10.5
31.8
63
65
K70.4
ICD-10 Finland
Alcoholic hepatic failure
44.4
31.2
38
9
F10.73
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol dementia
167.1
30.9
32
*
N05AB01
ATC
dixyrazine; systemic
18.8
30.0
46
26
N05AX08
ATC
risperidone; systemic
5.4
29.8
95
198
N05AA02
ATC
levomepromazine; systemic
6.5
29.0
78
131
F10.03
ICD-10 Finland
Alcohol-related acute intoxication with delirium
57.5
28.4
33
6
K86.00
ICD-10 Finland
Acute pancreatitis caused by alcohol
10.7
27.7
54
54
R27.0
ICD-10 Finland
Ataxia, unspecified
49.2
27.7
33
7
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
4.5
27.1
102
253
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.5
26.9
65
94
S42.2
ICD-10 Finland
Fracture of upper end of humerus
7.1
26.2
66
101
N05AD01
ATC
haloperidol; systemic
7.6
25.9
62
88
N05AD03
ATC
melperone; systemic
16.6
25.7
41
26
K70.9
ICD-10 Finland
Alcoholic liver disease, unspecified
40.4
25.1
31
8
V03AA01
ATC
NA
7.7
25.0
59
82
SPAT1265
SPAT
Breathalyser
14.3
24.8
42
31
R41.0
ICD-10 Finland
Disorientation, unspecified
7.4
24.8
60
87
F10.41
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol with seizures
50.2
24.4
29
6
SPAT1222
SPAT
Counselling/guidance promoting independent living
3.2
23.8
144
528
F10.8
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Other mental and behavioural disorders
129.3
23.7
25
*
3050A
ICD-9 Finland
Nondependent abuse of drugs, Alcohol abuse
16.0
23.5
38
25
N03AF01
ATC
carbamazepine; oral, rectal
4.8
23.4
81
184
G62.9
ICD-10 Finland
Polyneuropathy, unspecified
5.9
23.1
66
120
N03AG01
ATC
valproic acid; systemic, rectal
5.1
23.1
75
159
E51.2
ICD-10 Finland
Wernicke encephalopathy
86.3
22.8
25
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
4.9
22.7
77
171
N06AB03
ATC
fluoxetine; oral
3.4
22.3
118
393
P20
ICPC
Memory disturbance
3.4
21.7
112
365
SPAT1254
SPAT
Administration of medicine
3.0
21.7
138
523
G72.8
ICD-10 Finland
Other specified myopathies
9.0
21.7
46
54
SPAT1227
SPAT
Substance abuse rehabilitation
32.3
21.6
28
9
SPAT1216
SPAT
Assessment of functional ability
2.9
21.4
144
566
G40.51
ICD-10 Finland
Epileptic seizures related to alcohol
61.9
21.0
24
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.3
21.0
255
1389
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
4.3
20.7
81
208
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.0
20.7
87
239
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
5.6
20.3
61
118
C03CA01
ATC
furosemide; systemic
2.2
20.3
261
1455
N05AH03
ATC
olanzapine; systemic
5.0
20.2
67
145
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.9
20.1
86
240
R26.0
ICD-10 Finland
Ataxic gait
29.9
19.7
26
9
S72.0
ICD-10 Finland
Fracture of neck of femur
5.7
19.5
57
107
F10
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol
47.4
19.3
23
5
D64.9
ICD-10 Finland
Anaemia, unspecified
3.1
19.0
111
394
N06AB10
ATC
escitalopram; oral
2.7
18.9
146
621
F10.74
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol otherwise permanently impaired intelligence
+∞
18.8
18
*
S82.6
ICD-10 Finland
Fracture of lateral malleolus
4.3
18.6
71
178
SPAT1234
SPAT
Support of social functional capacity
5.0
18.4
60
128
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
4.8
18.3
63
142
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.1
18.1
73
193
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
4.6
18.1
64
149
2910A
ICD-9 Finland
Alcoholic psychoses, Alcohol withdrawal delirium
53.9
18.0
21
*
EBA15
NOMESCO Finland
Extraction of large number of teeth
4.4
17.9
66
160
K86.08
ICD-10 Finland
Alcohol-induced chronic pancreatitis
18.6
17.9
27
15
N03AX14
ATC
levetiracetam; systemic
6.5
17.9
47
77
S22.3
ICD-10 Finland
Fracture of rib
3.5
17.8
89
282
V03AB30
ATC
NA
12.9
17.8
31
25
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.0
17.4
108
400
K85
ICD-10 Finland
Acute pancreatitis
7.2
16.9
41
60
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
7.7
16.9
39
53
K70.0
ICD-10 Finland
Alcoholic fatty liver
13.1
16.8
29
23
F10.6
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Amnesic syndrome
+∞
16.7
16
*
G31.0
ICD-10 Finland
Circumscribed brain atrophy
+∞
16.7
16
*
F10.4
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state with delirium
92.2
16.6
18
*
S01.1
ICD-10 Finland
Open wound of eyelid and periocular area
7.1
16.4
40
59
F10.23
ICD-10 Finland
Alcohol dependence currently abstinent but using aversion-inducing or inhibitory medication
21.5
16.1
23
11
N06AB06
ATC
sertraline; oral
3.3
16.0
83
271
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
4.0
15.9
65
174
F10.01
ICD-10 Finland
Alcohol-related acute intoxication with permanent or other somatic damage
16.1
15.8
25
16
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.0
15.8
98
362
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
2.6
15.7
124
530
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
5.7
15.7
45
83
A98
ICPC
Health maint/preventive medicine
0.5
15.0
508
6000
N06AX16
ATC
venlafaxine; oral
2.7
14.7
104
417
SPAT1229
SPAT
Assessment of need for aid
3.3
14.6
75
242
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
14.6
123
544
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
6.4
14.6
38
62
F10.59
ICD-10 Finland
Alcohol psychosis, mixed type
152.9
14.5
15
*
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
152.9
14.5
15
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.2
13.8
156
798
R18
ICD-10 Finland
Ascites
7.8
13.8
31
41
N05BE01
ATC
buspirone; oral
5.5
13.7
40
76
F10.06
ICD-10 Finland
Alcohol-related acute intoxication with seizures
76.6
13.6
15
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.6
13.6
109
468
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.0
13.6
33
49
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
34.7
13.5
17
5
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.1
13.5
78
274
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
13.5
158
820
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
13.2
136
666
A09AA02
ATC
multienzymes (lipase, protease etc.)
7.3
13.2
31
44
G40
ICD-10 Finland
Epilepsy
17.1
13.0
20
12
E87.2
ICD-10 Finland
Acidosis
17.1
13.0
20
12
SPAT1247
SPAT
Outpatient detoxication and monitoring
19.5
13.0
19
10
R11
ICD-10 Finland
Nausea and vomiting
3.4
12.6
63
200
SPAT1307
SPAT
Psychosocial counselling and guidance
4.8
12.5
41
89
R42
ICD-10 Finland
Dizziness and giddiness
2.1
12.2
159
862
N05AF03
ATC
chlorprothixene; systemic
5.1
12.2
38
78
K92.1
ICD-10 Finland
Melaena
3.3
12.2
62
200
L89
ICD-10 Finland
Decubitus ulcer and pressure area
6.8
12.1
30
46
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
8.9
12.1
25
29
NHJ10
NOMESCO Finland
Internal fixation of fracture of ankle using wire, rod, cerclage or pin
4.0
12.1
48
126
N05BA06
ATC
lorazepam; systemic, sublingual
3.7
12.1
53
152
G41.9
ICD-10 Finland
Status epilepticus, unspecified
13.7
12.0
20
15
OAB43
SPAT
NA
0.1
11.9
*
403
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
11.8
149
795
A04
ICPC
Weakness/tiredness general
2.5
11.8
93
396
C03DA01
ATC
spironolactone; oral
2.4
11.8
103
462
7803A
ICD-9 Finland
General symptoms, Convulsions
12.1
11.4
20
17
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
5.8
11.3
31
55
K29.2
ICD-10 Finland
Alcoholic gastritis
17.4
11.2
17
10
TAB00
NOMESCO Finland
Lumbar puncture
4.4
11.2
40
95
N03AF02
ATC
oxcarbazepine; oral
5.2
11.2
34
68
F10.02
ICD-10 Finland
Alcohol-related acute intoxication with other acute clinical complications
25.5
11.2
15
6
30300
ICD-8 Finland
Alcoholism, Episodic excessive drinking
7.2
11.1
26
37
W00
ICD-10 Finland
Fall on same level involving ice and snow
2.5
11.1
88
375
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.9
11.0
67
243
Z03
ICPC
Housing/neighbourhood problem
14.2
11.0
18
13
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
11.0
85
357
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
8.0
10.9
24
31
SPAT1240
SPAT
Therapeutic discussion
2.9
10.9
67
246
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
10.9
90
393
N03AB02
ATC
phenytoin; systemic
10.8
10.8
20
19
N06AX03
ATC
mianserin; oral
3.3
10.8
53
167
N06AA12
ATC
doxepin; systemic
3.4
10.8
51
156
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.1
10.8
33
67
S43.0
ICD-10 Finland
Dislocation of shoulder joint
3.9
10.8
43
114
F10.3
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Withdrawal state
18.1
10.8
16
9
M01AH05
ATC
etoricoxib; oral
0.6
10.7
219
3110
2918A
ICD-9 Finland
Alcoholic psychoses, Other specified alcoholic psychosis
21.8
10.7
15
7
A29
ICPC
General symptom/complaint other
2.5
10.7
86
369
R55
ICD-10 Finland
Syncope and collapse
2.4
10.6
96
438
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
0.3
10.6
20
670
W10
ICD-10 Finland
Fall on and from stairs and steps
3.4
10.5
51
159
S42.0
ICD-10 Finland
Fracture of clavicle
4.7
10.5
35
78
TKC20
NOMESCO Finland
Catheterisation of bladder
2.7
10.4
75
301
N28
ICPC
Limited function/disability (N)
7.9
10.4
23
30
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
10.4
100
470
SPAT1231
SPAT
Assessment of adjustments needed in living environment
7.3
10.3
24
34
P29
ICPC
Psychological sympt/compl other
4.2
10.3
38
94
309
Kela drug reimbursment
Nalmefene and naltrexone
23.7
10.3
14
6
F32.00
ICD-10 Finland
Mild depressive episode without somatic syndrome
3.9
10.2
41
110
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
5.1
10.1
31
63
NBJ62
NOMESCO Finland
Internal fixation of fracture of shoulder or upper arm using plate and screws, humerus
9.3
10.1
20
22
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.2
10.0
53
177
SPAT1053
SPAT
Memory test
2.1
9.9
116
596
A02BC02
ATC
pantoprazole; systemic
1.7
9.9
447
3562
E86
ICD-10 Finland
Volume depletion
4.6
9.9
33
74
Z08
ICPC
Social welfare problem
8.9
9.8
20
23
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.8
9.8
65
250
I85.9
ICD-10 Finland
Oesophageal varices without bleeding
9.7
9.8
19
20
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.8
9.7
192
1201
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.3
9.5
46
144
G93.4
ICD-10 Finland
Encephalopathy, unspecified
17.8
9.4
14
8
EBA00
NOMESCO Finland
Extraction of tooth
1.7
9.4
231
1546
G37.2
ICD-10 Finland
Central pontine myelinolysis
+∞
9.4
9
*
N05BA12
ATC
alprazolam; oral
2.4
9.4
81
362
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.9
9.2
57
209
Z02.7
ICD-10 Finland
Issue of medical certificate
2.9
9.2
54
193
T74.1
ICD-10 Finland
Physical abuse
6.4
9.1
23
37
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.0
9.1
52
182
S42.3
ICD-10 Finland
Fracture of shaft of humerus
11.7
9.1
16
14
K75.9
ICD-10 Finland
Inflammatory liver disease, unspecified
9.2
9.1
18
20
F10.22
ICD-10 Finland
Alcohol dependence is currently on clinically controlled discontinuation medication
37.2
9.0
11
*
E13.7
ICD-10 Finland
Other specified diabetes mellitus, with multiple complications
37.2
9.0
11
*
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.6
9.0
40
117
S06.3
ICD-10 Finland
Focal brain injury
5.6
9.0
25
46
T90.5
ICD-10 Finland
Sequelae of intracranial injury
5.9
9.0
24
42
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.9
8.9
28
59
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.0
8.9
51
179
L76
ICPC
Fracture: other
5.2
8.8
26
51
NA1AD
NOMESCO Finland
Cervical spine CT examination
3.5
8.8
40
119
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.5
8.8
25
47
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.6
8.8
63
255
30310
ICD-8 Finland
Alcoholism, Habitual excessive drinking
7.3
8.8
20
28
N06AB05
ATC
paroxetine; oral
3.0
8.8
50
175
S62.3
ICD-10 Finland
Fracture of other metacarpal bone
4.2
8.8
32
79
S70.0
ICD-10 Finland
Contusion of hip
4.0
8.7
34
89
N07BB04
ATC
naltrexone; oral
50.6
8.7
10
*
EBA30
NOMESCO Finland
Excision of root of tooth
2.8
8.6
55
208
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
7.1
8.6
20
29
P18
ICPC
Medication abuse
27.9
8.5
11
*
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.2
8.4
91
453
S01.8
ICD-10 Finland
Open wound of other parts of head
6.3
8.4
21
34
R33
ICD-10 Finland
Retention of urine
2.2
8.3
88
430
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.9
8.2
32
84
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.0
8.2
108
582
S02.20
ICD-10 Finland
Fracture of nasal bones, closed
6.1
8.2
21
35
J01FA10
ATC
azithromycin; systemic
0.6
8.2
176
2515
NG4AA
NOMESCO Finland
Lower leg X-ray examination
4.9
8.1
25
52
R40.2
ICD-10 Finland
Coma, unspecified
8.3
8.1
17
21
30320
ICD-8 Finland
Alcoholism, Alcoholic addiction
6.9
8.1
19
28
F02.89*G40.9
ICD-10 Finland
Dementia in epilepsy
33.7
8.1
10
*
G11.9
ICD-10 Finland
Hereditary ataxia, unspecified
33.7
8.1
10
*
5770D
ICD-9 Finland
Diseases of pancreas, Acute pancreatitis[PANCREATITIS ACUTA ALCOHOLICA NONHAEMORHAGICA]
17.4
8.1
12
7
F60.9
ICD-10 Finland
Personality disorder, unspecified
9.1
8.1
16
18
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
9.1
8.1
16
18
B18.2
ICD-10 Finland
Chronic viral hepatitis C
9.1
8.1
16
18
F17.29
ICD-10 Finland
Addiction caused by tobacco UNS
4.7
8.1
26
57
S01
ICD-10 Finland
Open wound of head
6.4
8.1
20
32
S72.1
ICD-10 Finland
Pertrochanteric fracture
4.6
7.9
26
58
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.6
7.9
26
58
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.3
7.9
71
324
C10AA07
ATC
rosuvastatin; oral
0.5
7.8
72
1290
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
8.6
7.8
16
19
S32.0
ICD-10 Finland
Fracture of lumbar vertebra
3.9
7.8
31
83
S22.4
ICD-10 Finland
Multiple fractures of ribs
3.9
7.8
31
83
N06DX01
ATC
memantine; oral
4.5
7.8
26
59
NE1AA
NOMESCO Finland
Pelvis X-ray examination
2.7
7.8
53
207
F05.8
ICD-10 Finland
Other delirium
9.5
7.8
15
16
P03
ICPC
Feeling depressed
3.0
7.8
44
153
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
7.8
81
1403
Z09.4
ICD-10 Finland
Follow-up examination after treatment of fracture
3.3
7.8
38
121
S82.0
ICD-10 Finland
Fracture of patella
6.5
7.7
19
30
NGJ60
NOMESCO Finland
Internal fixation of fracture of knee or lower leg using intramedullary nail, other or unspecified
7.5
7.7
17
23
M80.9
ICD-10 Finland
Unspecified osteoporosis with pathological fracture
6.8
7.6
18
27
Y07
ICD-10 Finland
Other maltreatment
18.6
7.6
11
6
P19
ICPC
Drug abuse
18.6
7.6
11
6
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.5
7.6
34
101
K86.9
ICD-10 Finland
Disease of pancreas, unspecified
12.0
7.6
13
11
G47.3
ICD-10 Finland
Sleep apnoea
0.5
7.6
66
1205
Z29
ICPC
Social problem NOS
6.3
7.6
19
31
K08.3
ICD-10 Finland
Retained dental root
2.4
7.6
65
291
N06AB08
ATC
fluvoxamine; oral
4.1
7.5
28
71
G25.0
ICD-10 Finland
Essential tremor
4.5
7.5
25
57
P99
ICPC
Psychological disorders other
4.9
7.5
23
48
N07BA03
ATC
varenicline; oral
2.8
7.4
45
166
S92.3
ICD-10 Finland
Fracture of metatarsal bone
3.9
7.4
29
77
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
3.1
7.4
39
131
S52.5
ICD-10 Finland
Fracture of lower end of radius
2.5
7.4
57
239
K72.9
ICD-10 Finland
Hepatic failure, unspecified
13.5
7.4
12
9
OAB48
SPAT
NA
0.0
7.4
*
212
N06AA09
ATC
amitriptyline; systemic
2.2
7.4
71
336
N02AX02
ATC
tramadol; systemic, rectal
1.6
7.3
311
2368
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.4
7.3
33
99
NFB20
NOMESCO Finland
Primary partial prosthetic replacement of hip joint using cement, other or unspecified
4.6
7.3
24
54
N03AE01
ATC
clonazepam; systemic
2.8
7.3
46
171
G40.59
ICD-10 Finland
Other special epileptic syndromes
+∞
7.3
7
*
C10AX09
ATC
ezetimibe; oral
0.3
7.3
20
562
R25.1
ICD-10 Finland
Tremor, unspecified
3.7
7.2
30
84
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
3.8
7.2
29
79
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
3.2
7.2
36
117
2913A
ICD-9 Finland
Alcoholic psychoses, Alcohol withdrawal hallucinosis
30.3
7.2
9
*
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
20.2
7.1
10
5
T50.9
ICD-10 Finland
Poisoning: Other and unspecified drugs, medicaments and biological substances
20.2
7.1
10
5
SPAT1274
SPAT
Brief intervention in person with addiction symptoms
20.2
7.1
10
5
SPAT1241
SPAT
Extensive assessment of psychosocial situation
8.9
7.1
14
16
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.1
155
993
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
7.0
99
546
K25.0
ICD-10 Finland
Gastric ulcer, Acute with haemorrhage
7.1
7.0
16
23
S00.0
ICD-10 Finland
Superficial injury of scalp
4.5
7.0
23
52
WYA20
NOMESCO Finland
Home visit
6.4
7.0
17
27
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
6.4
7.0
17
27
F41.09
ICD-10 Finland
UNS Panic Syndrome
5.5
6.9
19
35
I95.1
ICD-10 Finland
Orthostatic hypotension
3.4
6.9
31
93
E000001
ATC
NA
1.8
6.9
124
745
T51.0
ICD-10 Finland
Toxic effect: Ethanol
13.9
6.9
11
8
F10.0
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Acute intoxication
4.9
6.9
21
44
R13
ICD-10 Finland
Dysphagia
2.5
6.9
54
230
K05.31
ICD-10 Finland
Periodontitis pronounced
2.0
6.9
87
463
R01AD09
ATC
mometasone; nasal
0.6
6.9
126
1888
K22.6
ICD-10 Finland
Gastro-oesophageal laceration-haemorrhage syndrome
11.1
6.8
12
11
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
9.4
6.8
13
14
TNX33
NOMESCO Finland
Custom moulded cast, unspecified region
2.7
6.8
45
176
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.0
6.8
88
472
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.3
6.8
64
299
RS110
NOMESCO Finland
NA
40.4
6.8
8
*
IAB10
NOMESCO Finland
Psychiatric consultation concerning substance abuse
16.9
6.8
10
6
E14.9
ICD-10 Finland
Unspecified diabetes mellitus, without complications
4.8
6.8
21
45
A46
ICD-10 Finland
Erysipelas
1.8
6.7
113
665
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
2.2
6.7
66
313
EB1SA
NOMESCO Finland
Dental X-ray, bite-wing X-ray on one side of the mouth
0.6
6.7
128
1904
K76.7
ICD-10 Finland
Hepatorenal syndrome
22.7
6.7
9
*
F19.1
ICD-10 Finland
Mental and behavioural disorders due to multiple drug use and use of other psychoactive substances, harmful use
22.7
6.7
9
*
D07AA02
ATC
hydrocortisone; topical
2.0
6.7
83
437
G30.1
ICD-10 Finland
Alzheimer disease with late onset
6.5
6.7
16
25
N03AX09
ATC
lamotrigine; oral
3.3
6.7
31
96
QAB00
NOMESCO Finland
Suture of skin of head or neck
5.6
6.6
18
33
K86.3
ICD-10 Finland
Pseudocyst of pancreas
7.9
6.6
14
18
S01.7
ICD-10 Finland
Multiple open wounds of head
7.9
6.6
14
18
XA800
NOMESCO Finland
Neuropsychological investigation
2.8
6.6
39
142
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.5
6.6
49
202
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
6.6
49
202
F17.2
ICD-10 Finland
Mental and behavioural disorders due to use of tobacco, dependence syndrome
12.4
6.6
11
9
L57.0
ICD-10 Finland
Actinic keratosis
0.3
6.6
10
376
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
4.9
6.6
20
42
E11.1
ICD-10 Finland
Type 2 diabetes mellitus, with ketoacidosis
8.8
6.6
13
15
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.9
6.6
97
543
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.8
6.6
121
733
N02AA05
ATC
oxycodone; systemic
1.8
6.6
113
671
P01
ICPC
Feeling anxious/nervous/tense
2.8
6.5
39
143
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
4.0
6.5
24
61
G57.3
ICD-10 Finland
Lesion of lateral popliteal nerve
5.4
6.5
18
34
Z53.2
ICD-10 Finland
Procedure not carried out because of patient's decision for other and unspecified reasons
6.3
6.5
16
26
S97
ICPC
Chronic ulcer skin
2.6
6.5
45
179
R56.0
ICD-10 Finland
Febrile convulsions
70.4
6.4
7
*
N07
ICPC
Convulsion/seizure
70.4
6.4
7
*
N05CM02
ATC
clomethiazole; systemic
70.4
6.4
7
*
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.6
6.4
45
181
Z28
ICPC
Limited function/disability (Z)
14.5
6.4
10
7
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
0.4
6.4
31
692
J01DA01
ATC
[U] cefalexin; systemic
1.5
6.4
408
3364
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.1
6.3
23
58
R41.3
ICD-10 Finland
Other amnesia
3.9
6.3
24
63
L72
ICPC
Fracture: radius/ulna
11.1
6.3
11
10
K86.01
ICD-10 Finland
Late effects of pancreatitis caused by alcohol
11.1
6.3
11
10
G30.8
ICD-10 Finland
Other Alzheimer disease
9.4
6.3
12
13
F10.70
ICD-10 Finland
Residual or late-onset psychosis caused by alcohol flashbacks
+∞
6.3
6
*
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
+∞
6.3
6
*
E13.2
ICD-10 Finland
Other specified diabetes mellitus, with renal complications
+∞
6.3
6
*
5353A
ICD-9 Finland
Gastritis and duodenitis, Alcoholic gastritis
26.9
6.2
8
*
Z22.3
ICD-10 Finland
Carrier of other specified bacterial diseases
26.9
6.2
8
*
E78.0
ICD-10 Finland
Pure hypercholesterolaemia
0.5
6.2
46
887
R01AD12
ATC
fluticasone furoate; nasal
0.5
6.2
58
1041
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.6
6.2
44
178
F32.1
ICD-10 Finland
Moderate depressive episode
3.5
6.2
27
80
NFJ50
NOMESCO Finland
Internal fixation of fracture of neck of femur with nail or screw
7.8
6.1
13
17
S01.9
ICD-10 Finland
Open wound of head, part unspecified
4.1
6.1
22
55
D10
ICPC
Vomiting
3.3
6.1
28
86
S20.2
ICD-10 Finland
Contusion of thorax
2.6
6.1
41
162
R02
ICPC
Shortness of breath/dyspnoea
2.0
6.1
75
393
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
2.9
6.1
35
124
K20
ICD-10 Finland
Oesophagitis
5.0
6.1
18
37
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
2.8
6.1
36
132
RS230
NOMESCO Finland
NA
8.7
6.1
12
14
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.4
6.1
50
221
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.3
6.0
28
87
Y04.9
ICD-10 Finland
Assault by bodily force by unknown person
10.1
6.0
11
11
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
5.2
6.0
17
33
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.0
195
1380
N06AA06
ATC
trimipramine; systemic
3.7
6.0
24
66
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
4.0
6.0
22
56
WX730
NOMESCO Finland
Conventional respirator
4.0
6.0
22
56

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
142
186
9.12
105.34
4.3
3.2
35.6
34.2
umol/l
0.24
129
153
57
48
12.73
57.16
2.1
1.5
1.7
1.3
promille
0.69
49
39
269
1159
3.02
43.72
2.0
1.7
1185.6
1174.6
nmol/l
0.06
206
899
38
33
12.06
37.18
1.1
1.2
140.0
135.9
nmol/l
0.13
38
33
177
670
3.13
35.28
3.0
2.3
0.2
0.2
g/l
5.05
153
619
359
1991
2.49
33.53
3.5
2.2
302.6
278.0
u/l
0.18
344
1869
474
6212
0.39
33.12
4.1
4.8
4.2
4.5
mmol/l
6.63
419
5747
472
6169
0.40
31.59
4.1
4.7
1.4
1.4
mmol/l
0.07
414
5661
504
6341
0.42
27.74
4.5
5.3
2.4
2.7
mmol/l
10.60
444
5823
462
5996
0.43
26.88
3.7
4.3
1.4
1.4
mmol/l
0.03
402
5483
348
2049
2.26
26.71
4.1
2.7
62.1
57.2
u/l
0.79
326
1908
224
1125
2.39
24.64
4.1
4.0
0.7
0.8
mmol/l
12.33
208
1064
196
932
2.47
24.30
3.9
6.9
1.0
1.0
mmol/l
0.50
182
872
54
118
4.84
23.46
2.0
1.3
54.1
62.8
mmol/l
0.62
41
99
421
2784
2.12
22.96
5.4
5.6
32.5
35.0
g/l
12.93
393
2604
332
2010
2.14
22.83
5.8
4.6
—
—
—
0
0
31
40
8.03
22.68
2.4
1.3
—
—
—
0
0
85
278
3.31
21.13
2.3
2.5
273.5
660.8
ug/l
1.24
78
263
186
946
2.27
19.31
13.6
25.3
1.2
1.4
inr
—
6
138
36
66
5.67
18.99
3.3
1.2
—
—
—
0
0
473
3417
1.98
18.55
8.5
7.1
14.7
12.6
umol/l
1.29
451
3264
108
2226
0.40
17.69
3.6
3.1
—
—
—
0
0
300
4251
0.52
16.84
3.9
5.0
3.6
2.9
ug/l
0.20
261
3820
135
2499
0.44
16.60
2.5
3.1
0.6
0.7
ug/l
0.79
103
1696
39
87
4.67
16.51
5.4
5.3
336.1
363.6
umol/l
0.47
30
78
407
2867
1.88
16.43
8.3
7.1
1.2
1.2
mmol/l
5.91
378
2614
511
6136
0.51
16.26
4.8
4.8
6.4
6.1
mmol/l
1.76
449
5578
37
81
4.75
16.02
3.2
1.4
—
—
—
0
0
37
84
4.57
15.34
3.3
1.4
—
—
—
0
0
50
146
3.59
14.78
1.2
1.3
442.9
565.6
mg/l
1.94
45
132
244
1498
1.92
14.73
1.8
1.6
17.0
19.7
nmol/l
2.43
219
1267
37
87
4.42
14.69
3.6
1.4
—
—
—
0
0
225
1349
1.94
14.56
1.8
1.7
456.2
22575376.2
pmol/l
1.26
191
1134
603
6819
0.49
14.53
38.7
23.5
127.5
138.2
g/l
37.85
585
6712
603
6819
0.49
14.53
38.4
23.4
7.6
6.9
e9/l
10.89
579
6612
603
6818
0.49
14.49
38.2
23.3
93.2
91.6
fl
10.78
588
6712
603
6818
0.49
14.49
38.3
23.3
4.1
4.5
e12/l
47.52
578
6613
603
6817
0.49
14.44
38.1
23.2
31.2
30.6
pg
9.00
588
6710
603
6816
0.49
14.40
38.2
23.3
238.1
236.2
e9/l
0.22
583
6630
29
57
5.25
14.20
2.9
1.9
—
—
—
0
0
130
647
2.21
13.88
5.0
4.0
1.5
2.1
mmol/l
0.74
106
506
36
87
4.29
13.81
3.1
1.4
—
—
—
0
0
176
990
2.01
13.59
2.3
2.6
2.1
2.2
g/l
0.95
157
924
504
5983
0.55
13.14
6.7
6.2
40.7
40.8
mmol/mol
0.08
457
5526
43
124
3.61
12.95
1.1
1.4
24.1
1036.2
e6/l
0.62
34
102
43
124
3.61
12.95
1.1
1.4
13.1
76.3
e6/l
0.71
33
99
246
1574
1.82
12.72
2.4
2.1
3.3
3.0
mg/l
0.66
217
1343
34
85
4.14
12.49
3.5
1.4
—
—
—
0
0
121
610
2.16
12.45
10.5
10.1
—
—
—
0
0
588
6652
0.52
12.41
30.8
19.1
79.2
86.0
umol/l
4.56
588
6647
360
2591
1.72
12.27
2.5
2.0
90.0
92.4
pmol/l
0.41
227
1457
14
15
9.49
11.68
1.4
1.8
11.8
23.0
g/l
—
9
10
146
808
1.99
11.66
1.9
1.7
—
—
—
0
0
109
544
2.17
11.47
4.0
3.1
4.4
4.6
kpa
0.45
104
529
180
1081
1.87
11.23
2.4
2.6
10.8
13.1
umol/l
3.90
161
1008
21
38
5.65
11.22
1.0
1.0
340.7
216.4
ng/l
1.02
15
17
21
38
5.65
11.22
1.0
1.0
712.4
624.3
ng/l
0.39
15
18
588
6617
0.54
11.14
15.3
11.2
29.6
28.7
u/l
0.31
564
6387
121
639
2.06
10.97
9.8
8.5
2.0
1.4
mmol/l
1.61
116
617
145
818
1.95
10.91
2.2
2.6
2.1
1.8
%
1.53
131
735
137
760
1.97
10.82
4.0
2.9
15.6
10.1
umol/l
1.01
119
690
126
679
2.02
10.80
4.8
4.0
—
7.4
—
0
6
413
3154
1.66
10.77
8.6
8.0
1.2
1.2
mmol/l
6.35
355
2681
8
460
0.17
10.62
1.0
1.4
—
—
—
0
0
71
307
2.44
10.42
5.3
4.5
23.5
24.3
mmol/l
0.95
63
278
37
112
3.42
10.38
1.1
1.3
—
—
—
0
0
388
2934
1.64
10.38
10.1
10.3
1.2
1.3
inr
2.66
105
829
51
188
2.83
10.29
1.7
1.5
270.4
252.2
ug/g
0.19
26
109
159
946
1.86
10.12
2.4
2.7
22.6
23.9
%
0.36
130
814
150
880
1.87
9.97
9.6
9.3
0.8
1.1
mmol/l
0.33
121
681
39
127
3.18
9.76
1.9
1.4
—
—
—
0
0
17
29
5.97
9.62
1.9
1.4
95.0
66.7
umol/l
—
8
14
235
1591
1.68
9.49
3.5
3.0
—
—
—
0
0
15
23
6.63
9.38
1.9
2.0
515.5
5132.1
e6/l
—
10
13
262
1838
1.64
9.16
3.9
4.5
7.4
7.4
ph
0.41
58
356
99
520
2.04
9.06
2.0
2.2
404.8
363.8
nmol/l
0.91
87
479
14
9
15.80
9.05
2.4
1.0
—
—
—
0
0
137
805
1.85
9.00
9.8
9.7
94.6
95.2
%
0.53
137
776
95
493
2.06
8.98
3.9
3.7
7.4
7.4
ph
1.06
13
59
108
587
1.98
8.98
4.7
2.5
31.5
43.8
u/l
0.86
96
515
96
501
2.05
8.93
3.9
3.6
5.2
5.1
kpa
0.23
90
465
12
5
24.32
8.93
1.0
1.4
—
—
—
0
0
347
2622
1.58
8.84
5.3
3.9
38.5
64.1
ng/l
0.96
294
1974
198
1304
1.70
8.77
3.1
2.9
492.1
578.5
mosm/kgh2o
3.46
175
1115
106
1769
0.54
8.21
1.6
1.7
1.3
1.4
mmol/l
0.77
91
1460
73
355
2.17
8.16
1.6
1.9
1.6
1.6
g/l
0.11
58
301
105
584
1.92
8.14
1.5
1.5
—
—
—
0
0
272
1971
1.58
8.12
2.4
3.7
2.3
2.3
mmol/l
0.22
221
1724
280
2044
1.58
8.10
2.9
2.7
—
—
—
0
0
374
4577
0.65
8.07
4.2
4.2
—
—
—
0
0
95
517
1.95
7.85
5.7
6.2
—
—
—
0
0
21
52
4.12
7.84
1.3
1.4
—
—
—
0
0
429
5074
0.66
7.56
35.6
20.6
333.0
333.6
g/l
0.70
421
5042
120
713
1.81
7.55
1.5
1.6
—
—
—
0
0
21
645
0.31
7.37
1.9
1.5
—
—
—
0
0
103
589
1.86
7.32
1.5
1.7
—
—
—
0
0
5
305
0.16
7.29
1.4
1.5
—
—
—
0
0
202
1395
1.61
7.26
3.1
2.6
5.0
3.4
e6/l
1.38
186
1230
11
7
15.91
7.24
1.7
1.3
—
—
mmol/l
—
0
0
25
75
3.41
7.16
1.3
1.5
—
—
—
0
0
5
294
0.16
6.97
1.0
1.2
—
—
—
0
0
30
103
2.99
6.92
1.1
1.1
1.6
1.6
g/l
0.48
24
93
13
24
5.49
6.79
4.5
2.0
—
—
—
0
0
46
200
2.38
6.72
4.1
2.8
24.7
24.6
mmol/l
0.05
41
173
577
6370
0.64
6.70
26.3
15.4
—
—
—
0
0
43
182
2.44
6.66
6.2
5.6
7.4
7.4
ph
0.67
32
151
147
958
1.66
6.61
9.6
7.9
103.0
104.3
mmol/l
1.28
140
937
600
6563
0.63
6.61
34.2
19.2
3.9
4.0
mmol/l
9.28
582
6409
19
50
3.87
6.56
1.2
1.2
—
—
—
0
0
6
302
0.19
6.54
1.2
1.2
—
—
—
0
0
469
3937
1.48
6.50
8.3
5.5
7.0
6.9
mmol/l
0.56
447
3722
479
5480
0.67
6.44
28.1
17.2
36.5
40.4
%
9.60
264
3772
113
692
1.74
6.39
4.6
8.7
9.6
10.5
mmol/l
0.48
106
661
432
5029
0.68
6.25
34.2
19.6
14.5
13.8
%
15.87
425
4918
599
6537
0.64
6.18
34.7
19.0
137.9
139.7
mmol/l
18.91
581
6386
35
141
2.55
6.02
3.5
2.7
—
—
—
0
0
36
148
2.50
5.94
2.8
2.9
16.5
16.5
%
0.02
17
85
97
582
1.76
5.88
1.6
2.9
67.1
66.4
g/l
0.28
86
538
67
359
1.95
5.80
4.4
3.8
—
—
—
0
0
116
737
1.67
5.72
10.7
10.4
117.9
122.5
g/l
1.44
116
706
101
619
1.73
5.69
2.1
2.7
73.4
69.4
e9/l
0.44
81
491
64
342
1.95
5.59
4.1
2.7
1.9
1.2
%
2.34
64
342
46
219
2.17
5.47
6.1
4.1
3.9
4.0
mmol/l
0.51
40
206
464
3956
1.43
5.46
5.9
4.1
3526.3
1112.1
e6/l
0.35
20
63
14
34
4.17
5.37
1.1
1.1
—
—
—
0
0
151
1045
1.55
5.23
2.3
2.3
—
—
—
0
0
11
23
4.84
5.02
2.5
1.7
—
—
—
0
0
27
107
2.58
4.84
1.0
1.0
—
—
—
0
0
80
483
1.73
4.76
9.5
8.8
23.6
24.3
mmol/l
0.74
80
448
69
399
1.80
4.75
1.5
1.8
1.9
1.5
g/l
0.53
64
370
124
841
1.56
4.68
1.4
1.3
—
—
—
0
0
156
1113
1.50
4.66
2.7
3.4
2.5
2.4
mmol/l
0.52
128
974
34
154
2.26
4.59
5.9
6.0
2.7
2.6
mmol/l
0.09
28
107
22
82
2.73
4.45
1.3
1.6
—
—
—
0
0
77
469
1.71
4.45
1.6
2.7
—
—
—
0
0
34
158
2.20
4.34
2.1
2.4
130.2
131.6
g/l
0.08
25
118
81
505
1.67
4.30
1.7
2.3
12.5
10.9
g/l
1.45
74
464
12
31
3.92
4.27
1.1
1.0
—
—
—
0
0
54
300
1.86
4.25
7.9
4.6
—
—
—
0
0
7
251
0.27
4.22
1.0
1.1
—
—
—
0
0
35
168
2.13
4.13
3.6
4.2
—
—
—
0
0
94
619
1.59
4.02
4.9
4.6
—
—
—
0
0
32
151
2.17
3.95
2.8
3.5
—
—
—
0
0
264
2131
1.36
3.90
4.2
6.2
—
—
—
0
0
46
795
0.55
3.81
1.9
2.3
14.8
12.9
nmol/l
0.66
35
704
21
84
2.54
3.74
1.4
1.4
23252.3
19812.4
e6/l
0.11
12
48
286
2354
1.34
3.67
2.9
2.7
276.7
185.8
ug/l
0.83
261
2157
60
362
1.71
3.62
1.3
1.5
—
—
—
0
0
60
362
1.71
3.62
4.6
3.4
24.5
24.9
mmol/l
0.50
60
349
24
106
2.30
3.48
1.2
1.1
—
—
—
0
0
201
1579
1.37
3.47
3.0
2.6
—
—
—
0
0
276
2277
1.33
3.44
4.5
3.8
90.2
128.1
e6/l
0.43
220
1705
166
1268
1.39
3.39
4.4
3.7
1.0
1.0
kg/l
0.33
31
182
0
85
0.00
3.33
0.0
1.0
—
—
—
0
0
17
65
2.65
3.32
1.1
1.2
—
—
—
0
0
541
4914
1.33
3.31
10.3
8.3
90.2
79.7
u/l
5.93
515
4633
187
2331
0.74
3.20
1.9
2.1
—
—
—
0
0
5
181
0.27
3.14
2.4
1.7
—
—
—
0
0
5
183
0.27
3.14
2.2
2.1
12.0
12.2
mg/l
—
5
167
0
84
0.00
3.12
0.0
1.0
—
—
—
0
0
217
1773
1.31
2.81
3.8
3.3
—
—
—
0
0
244
2030
1.29
2.76
4.2
3.4
28.3
98.4
e6/l
1.47
210
1604
188
1524
1.31
2.56
5.6
7.2
—
—
—
0
0
362
3183
1.26
2.56
4.5
6.2
0.2
0.2
e9/l
0.61
311
2792
12
44
2.75
2.55
1.5
1.3
—
—
—
0
0
14
56
2.53
2.54
1.2
1.1
213.9
367.7
nmol/l
—
9
47
197
1614
1.30
2.47
4.8
3.8
0.0
0.0
estimate
0.50
65
538
167
1341
1.31
2.43
3.1
3.4
—
—
—
0
0
20
97
2.09
2.39
2.7
3.1
—
—
—
0
0
179
2169
0.77
2.37
3.3
3.3
454.7
267.6
mg/l
0.21
119
1492
349
3078
1.24
2.34
4.5
6.0
0.7
0.6
e9/l
3.48
298
2635
192
2295
0.78
2.27
3.9
4.0
15.4
8.9
mg/mmol
1.16
128
1542
36
575
0.61
2.27
1.7
2.4
129.5
155.0
ug/g
0.31
26
464
17
336
0.49
2.24
1.1
1.3
—
—
—
0
0
14
60
2.36
2.23
2.2
2.1
—
—
—
0
0
98
736
1.38
2.22
1.4
1.3
1000.0
408.2
titre
0.77
16
157
349
3091
1.23
2.22
4.4
6.0
0.0
0.0
e9/l
0.52
299
2660
11
42
2.64
2.19
2.9
3.3
—
—
—
0
0
219
1855
1.25
2.07
3.9
3.3
0.6
0.5
e6/l
0.16
187
1430
318
2815
1.22
1.97
4.7
6.3
0.6
0.6
%
0.03
302
2635
7
21
3.35
1.97
3.6
2.9
—
—
—
0
0
128
1024
1.30
1.92
1.6
1.4
4.3
2.8
g/l
4.79
78
648
0
53
0.00
1.87
0.0
3.2
—
36.9
—
0
19
393
3571
1.20
1.81
6.5
9.7
5.0
4.2
e9/l
4.70
336
3116
15
73
2.08
1.81
1.6
1.4
—
—
—
0
0
8
29
2.78
1.79
1.3
1.1
—
—
—
0
0
326
2917
1.20
1.76
4.0
3.5
0.0
0.0
estimate
0.00
66
564
9
194
0.46
1.74
1.1
1.1
—
—
—
0
0
19
103
1.87
1.73
1.1
1.2
—
—
—
0
0
337
3033
1.20
1.69
5.0
4.3
—
—
—
0
0
142
1704
0.80
1.69
1.4
1.3
—
—
—
0
0
130
1062
1.27
1.66
1.3
1.2
1.3
1.8
u/ml
0.44
31
305
323
2900
1.19
1.66
4.8
6.6
9.5
9.1
%
1.13
306
2716
14
263
0.52
1.63
1.1
1.8
63.0
40.7
nmol/l
1.04
14
249
348
3150
1.19
1.62
4.6
6.1
1.7
2.0
e9/l
2.52
302
2768
6
20
3.01
1.58
1.0
1.0
2209.5
1479.5
miu/ml
—
6
20
240
2107
1.20
1.56
3.2
3.1
2798.1
1521.1
ng/l
1.38
208
1840
61
809
0.73
1.54
1.2
1.3
—
—
—
0
0
0
42
0.00
1.53
0.0
4.8
—
22.4
—
0
16
505
5348
0.84
1.50
4.6
4.1
2.1
2.0
mu/l
0.72
450
4816
320
2890
1.18
1.50
4.7
6.3
2.6
2.9
%
1.03
304
2697
12
58
2.09
1.49
2.0
2.2
9.2
10.8
%
0.57
12
58
326
2951
1.18
1.48
4.9
6.5
23.1
26.7
%
7.20
307
2755
320
2895
1.18
1.46
4.7
6.2
60.4
57.7
%
3.51
301
2714
321
2905
1.18
1.46
5.0
4.7
0.0
0.0
estimate
0.00
69
578
18
102
1.78
1.46
1.1
1.1
19.6
43.8
iu/ml
—
7
22
449
4185
1.17
1.40
4.9
4.2
—
—
—
0
0
31
206
1.53
1.40
4.4
3.8
—
—
—
0
0
42
579
0.71
1.37
1.3
1.4
—
—
—
0
0
588
6128
0.83
1.36
28.5
16.1
32.1
27.8
mg/l
1.88
549
4945
9
42
2.16
1.34
3.1
2.6
—
—
—
0
0
66
509
1.32
1.33
4.6
4.3
1.2
1.2
mmol/l
1.21
61
454
5
18
2.79
1.28
1.0
1.1
—
—
—
0
0
323
2951
1.16
1.26
4.1
3.5
0.0
0.0
estimate
0.50
63
536
57
434
1.34
1.26
14.3
13.3
—
—
—
0
0
31
212
1.48
1.24
1.3
2.9
38.3
37.4
g/l
0.35
25
181
152
1306
1.20
1.24
5.6
4.0
435.6
461.9
ng/l
0.04
133
1086
39
280
1.41
1.23
1.2
1.4
—
38.6
—
0
5
5
19
2.64
1.21
2.4
1.2
11.1
13.0
umol/l
—
5
14
56
721
0.76
1.19
1.4
1.3
—
—
—
0
0
25
366
0.67
1.15
2.8
2.9
—
—
—
0
0
68
849
0.78
1.15
1.3
1.3
16.6
13.7
u/ml
0.11
13
334
8
154
0.51
1.15
1.0
1.1
—
—
—
0
0
198
2218
0.86
1.11
3.1
3.2
6.8
8.3
mmol/l
4.63
155
1857
25
169
1.50
1.08
1.7
1.6
—
—
—
0
0
7
33
2.13
1.05
1.0
1.2
—
—
—
0
0
69
555
1.27
1.05
3.5
3.2
—
—
—
0
0
23
155
1.50
1.02
1.2
1.6
—
—
—
0
0
0
31
0.00
0.96
0.0
1.4
—
—
—
0
0
13
78
1.68
0.92
1.2
1.4
5.6
6.4
mmol/l
0.49
13
73
56
448
1.27
0.91
1.4
1.4
—
—
—
0
0
6
29
2.08
0.89
1.2
1.9
—
—
—
0
0
8
46
1.75
0.82
1.1
1.2
—
—
—
0
0
49
393
1.26
0.80
4.1
2.9
0.2
0.2
e6/l
0.01
49
384
0
25
0.00
0.79
0.0
8.1
—
—
—
0
0
8
48
1.67
0.79
3.5
4.5
—
—
—
0
0
256
2759
0.89
0.78
13.9
10.4
0.0
0.0
e9/l
0.37
198
2253
117
1324
0.86
0.76
3.6
4.8
—
—
—
0
0
53
436
1.23
0.72
2.8
4.3
116.2
102.6
ng/l
0.25
45
391
144
1296
1.14
0.69
1.9
1.8
1.9
1.3
mg/l
1.09
115
1010
60
504
1.21
0.67
5.1
3.8
—
—
—
0
0
5
28
1.79
0.66
3.6
2.2
—
—
—
0
0
30
233
1.30
0.65
1.8
4.0
69.0
87.5
mg/l
0.28
21
192
30
234
1.29
0.64
1.8
4.0
45.3
108.5
mg/l
0.60
21
195
28
217
1.30
0.62
2.1
2.5
129.5
113.6
ug/min
0.08
11
132
10
63
1.59
0.62
1.6
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
74
642
1.17
0.60
3.0
2.5
6.0
8.3
ug/l
1.15
66
573
0
22
0.00
0.59
0.0
1.4
—
—
—
0
0
11
72
1.54
0.59
3.4
4.3
—
—
—
0
0
6
37
1.63
0.55
1.8
1.5
—
—
—
0
0
6
38
1.58
0.54
1.3
1.0
—
—
—
0
0
9
64
1.41
0.51
1.4
1.2
—
—
—
0
0
9
65
1.39
0.50
1.4
1.6
—
—
—
0
0
21
268
0.78
0.49
1.7
1.7
—
—
—
0
0
81
907
0.88
0.48
1.3
1.2
86.2
36.9
iu/ml
0.51
20
284
7
49
1.43
0.46
1.0
1.1
—
—
—
0
0
5
82
0.61
0.46
3.8
3.5
9.8
5.3
nmol/l
—
5
82
5
83
0.60
0.46
1.0
1.2
—
—
—
0
0
22
174
1.27
0.45
1.9
3.9
—
—
—
0
0
14
104
1.35
0.43
1.4
1.6
—
—
—
0
0
120
1103
1.10
0.43
3.7
3.2
2.7
1.0
e6/l
1.45
65
663
6
94
0.64
0.42
1.0
1.2
—
—
—
0
0
5
32
1.57
0.42
1.2
1.3
825.6
248.3
iu/ml
—
5
32
0
16
0.00
0.41
0.0
2.5
—
1.2
—
0
16
19
150
1.27
0.40
4.4
3.8
23.4
32.3
mg/l
—
10
101
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
35
298
1.18
0.39
1.5
1.2
—
—
—
0
0
22
269
0.81
0.39
1.5
1.2
—
—
—
0
0
11
80
1.38
0.38
1.1
1.1
—
—
—
0
0
30
253
1.19
0.37
2.3
3.7
0.7
0.2
g/l
—
8
117
441
4526
0.94
0.35
4.2
4.0
18.9
12.5
mm/h
9.02
403
4163
6
43
1.40
0.35
2.2
1.7
—
—
—
0
0
17
136
1.26
0.34
1.1
1.5
—
—
—
0
0
15
118
1.28
0.33
1.7
3.2
62.3
58.3
%
0.56
15
118
24
202
1.19
0.31
1.2
1.4
—
—
—
0
0
23
193
1.20
0.31
2.8
3.1
1.6
1.7
mg/l
0.22
23
177
7
99
0.70
0.31
1.0
1.2
—
168.8
—
0
38
22
184
1.20
0.30
9.0
10.8
12.0
11.5
mmol/l
0.28
22
164
22
184
1.20
0.30
9.0
10.8
102.8
105.5
mmol/l
0.89
22
164
28
325
0.86
0.30
2.2
2.3
—
—
—
0
0
7
54
1.30
0.30
1.4
1.3
—
—
—
0
0
7
55
1.28
0.30
1.3
1.1
—
—
—
0
0
86
797
1.09
0.29
1.4
1.6
—
—
—
0
0
14
112
1.25
0.28
1.6
2.9
5.6
4.5
e9/l
0.49
14
112
38
425
0.89
0.26
2.6
2.9
3.9
4.0
e9/l
0.13
25
330
10
127
0.78
0.25
1.6
1.8
—
—
—
0
0
11
87
1.27
0.24
2.6
4.6
—
—
—
0
0
40
360
1.12
0.24
1.1
1.2
—
—
—
0
0
5
40
1.25
0.22
2.2
3.3
—
—
—
0
0
154
1607
0.95
0.22
4.8
3.3
—
—
—
0
0
15
178
0.84
0.22
2.2
1.7
15368.3
14967.5
e6/l
—
10
131
195
2021
0.95
0.22
5.6
4.0
—
—
—
0
0
54
498
1.09
0.21
3.3
4.7
0.0
0.1
%
0.96
17
142
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.3
—
—
—
0
0
0
13
0.00
0.21
0.0
5.4
—
—
—
0
0
10
80
1.25
0.20
1.1
2.5
—
—
—
0
0
6
48
1.25
0.20
1.0
1.1
—
4.8
—
0
18
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
13
108
1.21
0.20
1.2
4.2
—
—
—
0
0
9
115
0.78
0.20
1.2
1.3
—
—
—
0
0
6
50
1.20
0.19
1.8
1.4
—
—
—
0
0
29
322
0.90
0.19
3.7
3.7
—
—
—
0
0
11
91
1.21
0.17
3.5
2.7
—
—
—
0
0
7
61
1.15
0.17
1.3
1.3
—
—
—
0
0
18
157
1.15
0.17
1.5
1.2
—
—
—
0
0
5
66
0.76
0.17
2.0
2.3
—
—
—
0
0
8
71
1.13
0.16
1.3
1.2
—
—
—
0
0
11
130
0.84
0.16
2.2
2.1
—
—
—
0
0
36
333
1.09
0.14
7.4
7.6
2.3
1.7
%
1.72
36
310
11
93
1.19
0.14
3.5
2.7
105.4
105.4
mmol/l
0.01
11
93
11
93
1.19
0.14
3.5
2.7
4.3
4.1
mmol/l
0.44
11
93
9
107
0.84
0.13
1.6
2.6
—
—
—
0
0
29
268
1.09
0.12
1.1
1.2
70.1
157.5
iu/ml
0.90
13
94
423
4181
1.03
0.12
3.5
3.4
15.0
14.9
pmol/l
0.36
372
3748
10
86
1.16
0.11
2.9
2.5
—
—
—
0
0
41
387
1.06
0.11
3.3
2.7
—
—
—
0
0
5
46
1.09
0.09
2.0
1.3
—
—
—
0
0
10
112
0.89
0.07
1.8
1.4
—
—
—
0
0
8
91
0.88
0.06
1.5
1.8
—
—
—
0
0
8
91
0.88
0.06
1.5
1.8
—
—
—
0
0
8
91
0.88
0.06
1.5
1.8
—
—
—
0
0
8
91
0.88
0.06
1.5
1.8
—
—
—
0
0
58
595
0.97
0.04
1.4
1.5
—
—
—
0
0
19
180
1.06
0.04
4.6
4.6
—
—
—
0
0
31
299
1.04
0.04
1.6
1.3
541.6
275.8
u/ml
0.87
31
275
15
141
1.07
0.03
2.2
2.9
0.8
0.9
nmol/l
—
9
110
25
260
0.96
0.03
2.7
3.7
4.1
4.5
pmol/l
0.76
19
232
15
143
1.05
0.01
1.3
1.2
—
—
—
0
0
60
606
0.99
0.00
4.0
2.9
189.5
225.4
ng/l
0.32
55
548
12
125
0.96
0.00
2.1
1.6
—
—
—
0
0
16
162
0.99
0.00
1.0
1.2
—
—
—
0
0
22
218
1.01
0.00
16.2
11.2
—
—
—
0
0
53
527
1.01
0.00
3.4
4.7
0.2
0.1
%
0.09
19
167
56
563
0.99
0.00
3.2
4.6
0.7
0.9
%
0.24
20
183
74
737
1.00
0.00
2.4
4.4
10.8
32.1
ug/l
0.93
67
618
33
329
1.00
0.00
7.6
7.7
0.9
0.9
%
0.38
33
307
188
1878
1.00
0.00
2.5
2.9
371.7
6847.1
umol/l
6.29
158
1623
5
50
1.00
0.00
1.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
5.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.0
—
0
5
19
190
1.00
0.00
1.5
1.2
—
1.3
—
0
16
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
50
500
1.00
0.00
2.6
4.5
0.3
0.5
%
0.70
14
129
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
4.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_ALCODEGEN and mortality.

Females

Parameter HR [95% CI] p-value
G6_ALCODEGEN 7.086 [6.16, 8.15] < 0.001
Birth year 0.994 [0.99, 1.0] 0.159

During the follow-up period (1.1.1998 — 31.12.2019), 1024 out of 2337 females with G6_ALCODEGEN died.

Males

Parameter HR [95% CI] p-value
G6_ALCODEGEN 5.864 [5.32, 6.46] < 0.001
Birth year 0.987 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 4483 out of 8289 males with G6_ALCODEGEN died.

Mortality risk

Mortality risk for people of age

years, who have G6_ALCODEGEN.

N-year risk Females Males
1 0.797% 1.179%
5 3.618% 6.351%
10 9.524% 14.645%
15 18.008% 27.105%
20 29.468% 41.761%

Relationships between endpoints

↥

Index endpoint: G6_ALCODEGEN – Degeneration of the brain due to alcohol

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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