No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
635 |
4. Check minimum number of eventsNone |
635 |
5. Include endpointsNone |
635 |
6. Filter based on genotype QC (FinnGen only) |
635 |
Control definitions (FinnGen only)
- Control exclude
- H7_LENS
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H27
- Name in latin
- Aphakia
Aphakia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 10286 | 5262 | 4814 |
| Only index persons | 5128 | 2468 | 2660 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.14 | 0.15 | 0.13 |
| Only index persons | 0.10 | 0.09 | 0.10 |
| Median age at first event (years) | |||
| Whole population | 63.75 | 67.32 | 59.82 |
| Only index persons | 53.87 | 59.58 | 48.57 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 635 | 241 | 394 |
| Unadjusted period prevalence (%) | 0.14 | 0.08 | 0.17 |
| Median age at first event (years) | 55.83 | 55.01 | 56.32 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 574
- Matched controls
- 5744
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H27.0
ICD-10 Finland
Aphakia
+∞
323.0
359
*
Z96.1
ICD-10 Finland
Presence of intraocular lens
84.1
200.5
220
42
37872
ICD-8 Finland
Other diseases of eye, Aphakia artefacta, acquisita
+∞
192.8
174
*
3793A
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[APHAKIA]
+∞
160.0
146
*
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
10.8
137.8
338
671
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
83.2
135.0
149
24
S01ED51
ATC
timolol, combinations; ophthalmic
23.2
122.0
182
112
H25.1
ICD-10 Finland
Senile nuclear cataract
50.9
109.1
131
33
S01ED01
ATC
timolol; ophthalmic
26.1
102.0
145
73
114
Kela drug reimbursment
Glaucoma
13.9
98.6
182
185
WX140
NOMESCO Finland
Parabulbar anesthesy
55.9
95.8
113
25
37402
ICD-8 Finland
Cataract, Senilis
+∞
84.4
79
*
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
165.5
82.4
85
6
H33.0
ICD-10 Finland
Retinal detachment with retinal break
57.3
81.8
96
20
CKD60
NOMESCO Finland
Anterior vitrectomy
+∞
77.9
73
*
CJF00
NOMESCO Finland
Secondary implantation of artificial lens in anterior chamber
+∞
73.5
69
*
S01EC01
ATC
acetazolamide; systemic
34.8
64.6
84
28
H26.4
ICD-10 Finland
After-cataract
355.5
63.7
63
*
3626
FHL
Extracapsular cataract surgery and implantation of an artificial lens
+∞
63.7
60
*
CJF10
NOMESCO Finland
Secondary implantation of artificial lens in posterior chamber
+∞
62.6
59
*
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
47.7
61.8
75
18
S01EE01
ATC
latanoprost; ophthalmic
13.7
60.2
108
95
WX100
NOMESCO Finland
Conjunctival surface anesthesia
53.7
59.9
71
15
CKD65
NOMESCO Finland
Pars plana or pars plicata vitrectomy
56.6
59.6
70
14
3631
FHL
Setting up an artificial lens as the only procedure
+∞
56.1
53
*
3661A
ICD-9 Finland
Cataract, Senile cataract
+∞
55.1
52
*
37401
ICD-8 Finland
Cataract, Praesenilis
+∞
54.0
51
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
9.3
53.0
117
153
37403
ICD-8 Finland
Cataract, Complicata
530.9
50.2
49
*
37404
ICD-8 Finland
Cataract, Secundaria
+∞
49.7
47
*
CJB10
NOMESCO Finland
Laser discission of secondary cataract
113.9
48.6
52
5
H27.1
ICD-10 Finland
Dislocation of lens
+∞
44.3
42
*
H25.8
ICD-10 Finland
Other senile cataract
85.1
42.5
47
6
CKD94
NOMESCO Finland
Combined vitrectomy and procedure on lens through pars plana
59.2
42.1
49
9
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
3.4
39.4
263
1134
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.0
38.4
139
346
S01EA03
ATC
apraclonidine; ophthalmic
107.1
37.2
40
*
TCG10
NOMESCO Finland
Removal of sutures from cornea
+∞
36.8
35
*
37405
ICD-8 Finland
Cataract, Traumatica
+∞
36.8
35
*
S01EX03
ATC
NA
20.4
36.0
54
29
S01EC04
ATC
brinzolamide; ophthalmic
18.1
33.9
53
32
XCK00
NOMESCO Finland
Perimetry
9.0
32.1
70
87
H40.0
ICD-10 Finland
Glaucoma suspect
7.8
32.0
77
112
Q12.0
ICD-10 Finland
Congenital cataract
+∞
31.5
30
*
Z94.7
ICD-10 Finland
Corneal transplant status
+∞
31.5
30
*
37520
ICD-8 Finland
Glaucoma, Secondary
168.8
31.0
32
*
CHF05
NOMESCO Finland
Transscleral laser coagulation of ciliary body
+∞
30.5
29
*
XCK10
NOMESCO Finland
Photography of fundus of eye
5.9
28.9
86
167
S01BA01
ATC
dexamethasone; ophthalmic (corticosteroids, plain)
10.4
28.6
57
60
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
14.0
28.4
49
38
3625
FHL
Extracapsular nuclear cataract removal
+∞
28.3
27
*
S01BC05
ATC
ketorolac; ophthalmic
16.7
28.1
45
29
CKD10
NOMESCO Finland
Insufflation of vitreous cavity
44.9
28.0
34
8
CKD40
NOMESCO Finland
Endophotocoagulation of retina
49.8
27.7
33
7
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.4
27.4
75
131
3610A
ICD-9 Finland
Retinal detachments and defects, Retinal detachment with retinal defect
65.3
27.2
31
5
S01BA04
ATC
prednisolone; ophthalmic (corticosteroids, plain)
15.8
26.9
44
30
CKD20
NOMESCO Finland
Removal of vitreous body substitute
146.6
26.8
28
*
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
9.3
26.4
56
66
H26.2
ICD-10 Finland
Complicated cataract
+∞
26.2
25
*
CGG45
NOMESCO Finland
Full thickness transplantation of cornea using homograft
+∞
26.2
25
*
S01FA01
ATC
atropine; ophthalmic
37.5
25.4
32
9
S01AX11
ATC
[U] ofloxacin; ophthalmic
10.4
25.3
50
52
CJF15
NOMESCO Finland
Secondary implantation of skleral fixed artificial lens in posterior chamber
+∞
25.2
24
*
74439
ICD-8 Finland
Congenital anomalies of eye, Cataracta NUD
+∞
25.2
24
*
WX142
NOMESCO Finland
Sub-tenon anesthesy
+∞
24.1
23
*
H18.1
ICD-10 Finland
Bullous keratopathy
+∞
24.1
23
*
3642
FHL
Anterior vitrectomy
+∞
24.1
23
*
S01BA07
ATC
fluorometholone; ophthalmic (corticosteroids, plain)
19.5
23.3
35
19
S01EE05
ATC
tafluprost; ophthalmic
12.9
23.1
41
34
T85.2
ICD-10 Finland
Mechanical complication of intraocular lens
+∞
23.1
22
*
XCH00
NOMESCO Finland
Eye pressure measurement
11.5
23.0
43
40
3643
FHL
Vitrectomy through pars Plana
238.7
22.8
23
*
S01EE03
ATC
bimatoprost; ophthalmic
16.6
22.6
36
23
ZXA05
NOMESCO Finland
Left side
3.0
22.3
155
636
CKD91
NOMESCO Finland
Extended vitrectomy through pars plana
54.2
22.2
26
5
CJF30
NOMESCO Finland
Reduction of dislocation of artificial lens
+∞
22.0
21
*
H20.1
ICD-10 Finland
Chronic iridocyclitis
32.5
21.7
28
9
H43.1
ICD-10 Finland
Vitreous haemorrhage
15.4
21.4
35
24
87011
ICD-8 Finland
Open wound of eye and orbit, Perforans oculi, Complicata
+∞
20.9
20
*
CKD93
NOMESCO Finland
Extended combined procedure on vitreous body and retina
79.7
20.8
23
*
CG2T4
NOMESCO Finland
Topography assessment of cornea
79.7
20.8
23
*
H40.3
ICD-10 Finland
Glaucoma secondary to eye trauma
217.2
20.7
21
*
3793C
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[PSEUDOPHAKIA]
217.2
20.7
21
*
S01EB01
ATC
pilocarpine; ophthalmic
23.4
20.6
29
13
ZXA00
NOMESCO Finland
Right side
2.7
19.6
157
696
S01EC03
ATC
dorzolamide; ophthalmic
19.0
19.3
29
16
CKC70
NOMESCO Finland
Circular buckling of sclera
+∞
18.8
18
*
H26.1
ICD-10 Finland
Traumatic cataract
+∞
18.8
18
*
WX002
NOMESCO Finland
Sedation and analgesia
3.1
18.8
116
434
S01BC03
ATC
diclofenac; ophthalmic
11.6
18.4
34
31
CJE99
NOMESCO Finland
Other extracapsular cataract operation using phakoemulsification technique
+∞
17.8
17
*
3656X
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA SECUNDARIA ALIA SEU NUD]
185.2
17.6
18
*
37301
ICD-8 Finland
Strabismus, Concomitans divergens
20.0
17.0
25
13
CG2X4
NOMESCO Finland
Optical coherence tomography (OCT) of cornea
65.2
16.8
19
*
S05.6
ICD-10 Finland
Penetrating wound of eyeball without foreign body
65.2
16.8
19
*
CA1AE
NOMESCO Finland
Eye and orbita ultrasound examination
65.2
16.8
19
*
H54.4
ICD-10 Finland
Blindness, monocular
36.2
16.8
21
6
S01CA02
ATC
prednisolone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
13.9
16.6
28
21
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
28.5
16.6
22
8
CKD15
NOMESCO Finland
Injection of vitreous substitute
174.6
16.6
17
*
H16.0
ICD-10 Finland
Corneal ulcer
6.3
16.5
44
74
3745
FHL
Hard membrane girding, cerclage with coagulation
61.7
15.8
18
*
37601
ICD-8 Finland
Detachment of retina, Secundaria
+∞
15.7
15
*
3619
FHL
Other operations in this group, such as corneal refractive surgery
+∞
15.7
15
*
7433A
ICD-9 Finland
Congenital anomalies of eye, Congenital cataract and lens anomalies
+∞
15.7
15
*
3639
FHL
Other measure in this category
164.0
15.5
16
*
CKD92
NOMESCO Finland
Combined vitrectomy and retinal procedure
39.2
15.5
19
5
S01EC54
ATC
brinzolamide, combinations; ophthalmic
39.2
15.5
19
5
CKC60
NOMESCO Finland
Local buckling of sclera using implant
+∞
14.6
14
*
H17.1
ICD-10 Finland
Other central corneal opacity
+∞
14.6
14
*
CJE00
NOMESCO Finland
Phakoemulsification
+∞
14.6
14
*
37600
ICD-8 Finland
Detachment of retina, Primaria
82.1
14.6
16
*
36402
ICD-8 Finland
Iritis, Iridocyclitis, uveitis chronica
153.5
14.5
15
*
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
13.8
14.3
24
18
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
11.3
14.1
26
24
S01FA04
ATC
cyclopentolate; ophthalmic
16.3
14.0
22
14
3747
FHL
Combined ablation and vitreous surgery with coagulation
76.9
13.6
15
*
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
76.9
13.6
15
*
3665A
ICD-9 Finland
Cataract, After-cataract
+∞
13.6
13
*
3663A
ICD-9 Finland
Cataract secondary to ocular disorders
+∞
13.6
13
*
37400
ICD-8 Finland
Cataract, Infantilis, juvenilis
+∞
13.6
13
*
CJW99
NOMESCO Finland
Other operation on lens
+∞
13.6
13
*
CHD50
NOMESCO Finland
Shunt operation on anterior chamber
+∞
13.6
13
*
H17.8
ICD-10 Finland
Other corneal scars and opacities
+∞
13.6
13
*
CKC30
NOMESCO Finland
Cryopexy of detached retina
+∞
13.6
13
*
3660C
ICD-9 Finland
Cataract, Infantile, juvenile and presenile cataract[CATARACTA PRAESENILIS]
+∞
13.6
13
*
H25.0
ICD-10 Finland
Senile incipient cataract
8.6
13.2
28
34
ZXA10
NOMESCO Finland
Bilateral
2.9
12.7
84
324
CGF10
NOMESCO Finland
Suture of laceration of cornea
71.4
12.6
14
*
CJ2M4
NOMESCO Finland
Scans and measurement printouts for intraocular lens power calculation
71.4
12.6
14
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
32.8
12.6
16
5
H3603, E103
ICD-10 Finland
NA
32.8
12.6
16
5
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
9.6
12.6
25
27
87091
ICD-8 Finland
Open wound of eye and orbit, Perforans oculi, Sequelae
+∞
12.5
12
*
3641A
ICD-9 Finland
Disorders of iris and ciliary body, Chronic iridocyclitis
+∞
12.5
12
*
H40.9
ICD-10 Finland
Glaucoma, unspecified
10.8
12.3
23
22
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
6.6
12.3
31
49
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.9
12.2
40
87
H57.1
ICD-10 Finland
Ocular pain
8.4
12.2
26
32
S01FA02
ATC
scopolamine; ophthalmic
13.7
12.0
20
15
S01EE04
ATC
travoprost; ophthalmic
8.4
11.7
25
31
S05.1
ICD-10 Finland
Contusion of eyeball and orbital tissues
9.5
11.6
23
25
37602
ICD-8 Finland
Detachment of retina, Foramen, ruptura retinae
+∞
11.5
11
*
3624
FHL
Extracapsular soft cataract removal
+∞
11.5
11
*
3621
FHL
In the aftermath of the dissection
+∞
11.5
11
*
Z90.0
ICD-10 Finland
Acquired absence of part of head and neck
+∞
11.5
11
*
3604
FHL
Penetration of the cornea
+∞
11.5
11
*
36409
ICD-8 Finland
Iritis, Unspecified
122.2
11.5
12
*
H36.09*E10.3
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic retinopathy
122.2
11.5
12
*
TCG00
NOMESCO Finland
Protection of cornea and sclera with soft lens
122.2
11.5
12
*
S01ED02
ATC
betaxolol; ophthalmic
11.4
11.1
20
18
H53.0
ICD-10 Finland
Amblyopia ex anopsia
44.1
10.9
13
*
W44
ICD-10 Finland
Foreign body entering into or through eye or natural orifice
8.7
10.6
22
26
H33.4
ICD-10 Finland
Traction detachment of retina
111.8
10.4
11
*
H26.02
ICD-10 Finland
Presenil cataract
111.8
10.4
11
*
87001
ICD-8 Finland
Open wound of eye and orbit, Perforans oculi, Non complicata (sive NUD)
+∞
10.4
10
*
CJF20
NOMESCO Finland
Removal of artificial lens
+∞
10.4
10
*
3792A
ICD-9 Finland
Other disorders of eye, Disorders of vitreous body
+∞
10.4
10
*
37700
ICD-8 Finland
Other diseases of retina and optic nerve, Haemorrhagia corporis vitrei
+∞
10.4
10
*
CG2S4
NOMESCO Finland
Photography of cornea
33.1
10.4
13
*
H18.4
ICD-10 Finland
Corneal degeneration
101.5
9.4
10
*
CFD10
NOMESCO Finland
Repair of conjunctiva
101.5
9.4
10
*
CHB10
NOMESCO Finland
Puncture of anterior chamber of eye with irrigation
101.5
9.4
10
*
CKD95
NOMESCO Finland
Extended combined vitectomy and lens procedure through pars plana
101.5
9.4
10
*
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
30.5
9.4
12
*
H40.4
ICD-10 Finland
Glaucoma secondary to eye inflammation
+∞
9.4
9
*
37409
ICD-8 Finland
Cataract, Unspecified
+∞
9.4
9
*
3627
FHL
Intracapsular cataract surgery
+∞
9.4
9
*
A10AA01
ATC
NA
6.2
9.3
24
40
H18.6
ICD-10 Finland
Keratoconus
37.2
9.0
11
*
3650A
ICD-9 Finland
Glaucoma, Borderline glaucoma [glaucoma suspect][SUSPICIO GLAUCOMATIS (AVOKULMA)]
37.2
9.0
11
*
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
37.2
9.0
11
*
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
9.0
51
178
H33.5
ICD-10 Finland
Other retinal detachments
18.9
9.0
13
7
3781A
ICD-9 Finland
Strabismus and other disorders of binocular eye movements, Divergent concomitant strabismus[STRABISMUS CONCOMITANS DIVERGENS]
50.7
8.7
10
*
3744
FHL
Pericardial identification surgery with coagulation (includes epi- and intrascleral indications and eg Lincoff catheter)
50.7
8.7
10
*
H35.30
ICD-10 Finland
Kuhnt-Junius degeneration
4.5
8.5
29
67
E10.5
ICD-10 Finland
Type 1 diabetes mellitus, With peripheral circulatory complications
20.3
8.5
12
6
H44.2
ICD-10 Finland
Degenerative myopia
91.2
8.4
9
*
CJE15
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in anterior chamber and iridectomy or iridotomy
+∞
8.3
8
*
CJF99
NOMESCO Finland
Other operation on artificial lens
+∞
8.3
8
*
3623
FHL
Extracapsular cataract aspiration
+∞
8.3
8
*
3718X
ICD-9 Finland
Corneal opacity and other disorders of cornea, Other corneal disorders
+∞
8.3
8
*
3662A
ICD-9 Finland
Cataract, Traumatic cataract
+∞
8.3
8
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
8.3
8
*
H33.2
ICD-10 Finland
Serous retinal detachment
+∞
8.3
8
*
CA1TM
NOMESCO Finland
Calculation of intraocular lens power
+∞
8.3
8
*
CG2Z4
NOMESCO Finland
Specialised imaging of cornea
+∞
8.3
8
*
Q87.4
ICD-10 Finland
Marfan syndrome
+∞
8.3
8
*
S01AA01
ATC
chloramphenicol; ophthalmic (antibiotics)
3.4
8.3
39
120
CKD70
NOMESCO Finland
Excision of preretinal or epiretinal membrane
14.7
8.2
13
9
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
11.9
8.1
14
12
XCH05
NOMESCO Finland
Eye pressure longterm registration
17.4
8.1
12
7
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
33.8
8.1
10
*
H18.5
ICD-10 Finland
Hereditary corneal dystrophies
33.8
8.1
10
*
XCD10
NOMESCO Finland
Electrophysiological examination of eye
7.9
7.9
17
22
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
4.4
7.9
27
63
E9179
ICD-8 Finland
Striking against or struck accidentally by objects
8.6
7.8
16
19
3503
FHL
Single muscle retroposition
45.5
7.7
9
*
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
2.7
7.7
53
211
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.9
7.7
24
51
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.4
7.7
65
290
S01AD03
ATC
aciclovir; ophthalmic
4.1
7.7
28
70
37898
ICD-8 Finland
Other diseases of eye, Disease of eyeball, ocular muscle and orbit NEC
25.3
7.6
10
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
9.0
7.6
15
17
H18.2
ICD-10 Finland
Other corneal oedema
81.0
7.4
8
*
S05.2
ICD-10 Finland
Ocular laceration and rupture with prolapse or loss of intraocular tissue
81.0
7.4
8
*
25002
ICD-8 Finland
Diabetes mellitus, Retinopathia diabetica
81.0
7.4
8
*
ZZL00
NOMESCO Finland
Free graft of amniotic membrane
81.0
7.4
8
*
H40
ICD-10 Finland
Glaucoma
13.6
7.4
12
9
3656F
ICD-9 Finland
Glaucoma associated with other ocular disorders[GLAUCOMA POST UVEITIDEM]
+∞
7.3
7
*
3660A
ICD-9 Finland
Cataract, Infantile, juvenile and presenile cataract[CATARACTA INFANTILIS]
+∞
7.3
7
*
3852
FHL
Reoperation for another reason
+∞
7.3
7
*
H17.0
ICD-10 Finland
Adherent leukoma
+∞
7.3
7
*
CJD30
NOMESCO Finland
Pars plana lensectomy
+∞
7.3
7
*
3768
FHL
Eye examination under general anesthesia
+∞
7.3
7
*
3714A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Corneal degenerations
+∞
7.3
7
*
R3120
NOMESCO Finland
Training in mobility skills
+∞
7.3
7
*
H18.8
ICD-10 Finland
Other specified disorders of cornea
20.3
7.1
10
5
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.3
7.1
65
300
WX110
NOMESCO Finland
Local anesthesy
1.6
7.0
279
2128
H16.9
ICD-10 Finland
Keratitis, unspecified
6.4
7.0
17
27
CKC10
NOMESCO Finland
Local photocoagulation of retina
5.9
7.0
18
31
S01AA12
ATC
tobramycin; ophthalmic
14.0
6.9
11
8
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
3.6
6.9
29
83
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
9.5
6.8
13
14
A10AA02
ATC
NA
3.3
6.8
32
100
25000
ICD-8 Finland
Diabetes mellitus, Sine complicatione
3.7
6.8
28
79
37303
ICD-8 Finland
Strabismus, Heterophoria (exophoria, esophroria, hypophoria)
40.5
6.8
8
*
3700A
ICD-9 Finland
Keratitis, Corneal ulcer
40.5
6.8
8
*
H54.0
ICD-10 Finland
Blindness, binocular
40.5
6.8
8
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
12.4
6.6
11
9
D07BA04
ATC
hydrocortisone and antiseptics; topical
2.4
6.6
55
244
CKC20
NOMESCO Finland
Cryopexy of undetached retina
70.5
6.4
7
*
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
70.5
6.4
7
*
36400
ICD-8 Finland
Iritis, Iridocyclitis acuta
11.2
6.3
11
10
3660B
ICD-9 Finland
Cataract, Infantile, juvenile and presenile cataract[CATARACTA JUVENILIS]
+∞
6.3
6
*
37100
ICD-8 Finland
Corneal opacity, Cicatrix (nubecula, macula, leucoma) cornea
+∞
6.3
6
*
CJF50
NOMESCO Finland
Removal and implantation of artificial lens in posterior chamber
+∞
6.3
6
*
CGF45
NOMESCO Finland
Suture of laceration of sclera
+∞
6.3
6
*
3632
FHL
Artificial lens removal
+∞
6.3
6
*
3793B
ICD-9 Finland
Other disorders of eye, Aphakia and other disorders of lens[DISLOCATIO LENTIS]
+∞
6.3
6
*
3649
FHL
Other measure in this category
+∞
6.3
6
*
3719
FHL
Other measure in this category
+∞
6.3
6
*
3716A
ICD-9 Finland
Corneal opacity and other disorders of cornea, Keratoconus
+∞
6.3
6
*
3812
FHL
Suture of corneal wound
+∞
6.3
6
*
H3603, E113
ICD-10 Finland
NA
26.9
6.2
8
*
H44.5
ICD-10 Finland
Degenerated conditions of globe
26.9
6.2
8
*
CA1ME
NOMESCO Finland
Ultrasound oculometry
26.9
6.2
8
*
CHD05
NOMESCO Finland
Selective lasertrabeculoplasty
6.4
6.2
15
24
C03CA01
ATC
furosemide; systemic
1.6
6.1
195
1391
TK800
NOMESCO Finland
Hemodialysis
6.8
6.1
14
21
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
92
501
1.98
7.68
9.0
5.3
1.1
1.0
mmol/l
2.08
86
465
123
746
1.80
7.36
1.8
1.7
1071.1
1166.5
nmol/l
0.60
97
573
253
1878
1.58
6.93
10.9
6.7
1.2
1.2
mmol/l
0.16
211
1578
101
598
1.82
6.51
3.2
2.3
13.0
12.9
umol/l
0.07
90
550
295
2302
1.52
6.27
7.2
4.7
7.3
6.8
mmol/l
2.42
275
2150
225
1663
1.55
6.11
5.9
4.6
34.4
35.1
g/l
0.86
206
1538
100
603
1.78
6.05
3.4
3.2
0.8
0.8
mmol/l
0.05
93
559
331
2672
1.50
5.84
3.9
3.6
15.1
14.9
pmol/l
0.71
291
2407
203
1510
1.50
5.19
4.1
3.6
46.1
47.1
ng/l
0.02
143
1072
85
511
1.76
5.19
3.3
2.4
21.3
22.9
%
0.62
69
441
158
1121
1.54
5.02
2.5
2.0
191.2
267.5
u/l
0.50
144
1039
139
961
1.57
4.94
2.3
1.9
3.0
3.1
mg/l
0.41
119
803
162
1161
1.53
4.90
5.1
3.7
19.3
8.9
mg/mmol
1.09
121
730
353
2958
1.43
4.72
8.4
7.0
85.5
79.2
u/l
0.77
325
2748
53
284
1.94
4.65
4.7
3.7
1.2
1.2
mmol/l
0.25
47
241
306
2505
1.43
4.62
5.4
4.5
18.7
2473.7
e6/l
—
7
46
87
546
1.69
4.55
3.2
2.3
2.2
2.3
g/l
1.06
79
503
221
1711
1.45
4.50
9.2
5.8
1.2
1.2
mmol/l
0.31
198
1537
447
3935
1.46
4.42
22.7
16.9
139.5
139.7
mmol/l
1.01
439
3813
162
1186
1.49
4.38
3.1
2.4
56.6
55.5
u/l
0.15
153
1094
447
3950
1.44
4.21
23.1
17.1
4.0
4.0
mmol/l
0.03
436
3825
389
3363
1.40
4.08
4.9
4.4
2.0
2.0
mu/l
0.41
345
3040
231
1839
1.40
3.91
4.5
3.6
0.0
0.0
estimate
0.00
47
326
228
1813
1.40
3.88
4.5
3.5
0.0
0.0
estimate
0.00
49
331
57
334
1.77
3.82
2.7
2.2
5.0
7.2
ug/l
0.82
46
291
264
2164
1.37
3.71
9.7
8.5
4.6
4.2
e9/l
1.68
236
1887
184
1420
1.41
3.69
4.5
3.4
—
—
—
0
0
320
2707
1.37
3.67
4.9
3.7
14.5
12.9
mm/h
1.00
294
2486
427
3791
1.38
3.56
19.0
14.3
30.2
26.0
mg/l
0.74
364
3030
134
982
1.46
3.55
5.5
3.9
0.0
0.0
estimate
0.50
42
318
17
63
2.74
3.51
3.5
2.2
16.8
16.7
%
—
7
34
225
1816
1.37
3.42
5.8
4.8
0.0
0.0
estimate
0.00
46
335
181
1412
1.39
3.38
4.8
3.8
—
—
—
0
0
166
1277
1.40
3.36
4.0
3.3
2.3
2.4
mmol/l
0.39
145
1117
110
787
1.48
3.28
1.7
1.7
1.4
1.2
mg/l
0.24
83
615
62
393
1.64
3.15
8.0
3.3
2.0
2.0
mmol/l
0.06
54
306
180
1417
1.38
3.15
3.1
2.1
78.4
77.0
nmol/l
0.28
163
1268
242
2004
1.33
3.03
6.8
5.9
14.7
11.9
umol/l
0.92
231
1902
62
403
1.60
2.87
3.2
3.3
—
—
—
0
0
153
1190
1.37
2.86
3.3
3.1
1750.3
1621.6
ng/l
0.17
134
1024
391
3492
1.31
2.74
7.0
5.6
42.2
40.2
mmol/mol
3.00
355
3212
15
60
2.53
2.71
1.3
1.2
—
—
—
0
0
155
1219
1.36
2.69
3.4
3.2
31.0
32.1
u/l
0.27
148
1160
22
106
2.11
2.65
4.1
2.8
24.8
25.0
mmol/l
0.05
16
88
21
100
2.14
2.61
1.4
1.6
—
—
—
0
0
14
56
2.53
2.54
1.5
1.8
—
—
—
0
0
47
298
1.62
2.43
2.5
2.9
64.7
63.5
ml/min/173m2
0.08
25
127
101
753
1.40
2.42
3.3
3.1
2.5
2.5
mmol/l
0.00
80
658
53
347
1.57
2.41
1.9
2.1
0.2
0.2
g/l
0.10
48
325
436
3986
1.30
2.38
12.3
9.9
26.9
26.4
u/l
0.14
419
3824
182
1490
1.31
2.38
3.3
2.6
184.3
146.2
ug/l
0.78
168
1357
74
526
1.46
2.30
28.7
26.6
1.4
1.5
inr
0.36
14
82
22
114
1.96
2.22
3.3
3.6
61.3
98.9
mg/l
0.31
17
96
22
114
1.96
2.22
3.3
3.6
42.1
37.1
mg/l
0.19
17
97
188
1559
1.29
2.22
2.2
2.0
90.7
95.0
pmol/l
0.78
105
817
13
280
0.45
2.20
2.0
1.7
—
—
—
0
0
138
1101
1.32
2.16
4.1
3.4
0.9
0.6
e6/l
0.41
110
827
93
698
1.39
2.15
1.2
1.2
3.6
1.0
u/ml
0.40
33
173
105
804
1.37
2.15
5.1
4.0
1.0
1.0
kg/l
0.12
13
110
6
14
4.31
2.15
3.0
5.4
—
—
—
0
0
34
205
1.69
2.15
7.1
3.0
26.0
25.0
mmol/l
0.64
34
197
10
37
2.73
2.11
1.2
1.5
—
—
—
0
0
17
83
2.08
2.02
2.1
1.2
—
—
—
0
0
8
26
3.10
2.01
1.1
1.3
—
—
—
0
0
166
1372
1.28
1.99
4.1
4.3
22.9
21.0
%
1.03
94
663
43
282
1.56
1.97
6.9
3.8
128.5
86.1
ng/l
0.96
38
248
17
84
2.05
1.96
2.9
2.1
131.0
132.5
g/l
0.07
12
63
104
808
1.34
1.95
1.8
1.7
111765104.5
424.3
pmol/l
0.49
85
673
10
39
2.59
1.92
1.6
1.3
—
—
—
0
0
199
1690
1.26
1.90
5.1
4.9
8.2
4.0
ug/l
0.34
173
1503
87
661
1.37
1.88
1.9
1.8
—
—
—
0
0
39
255
1.56
1.83
4.1
3.6
5.1
5.2
kpa
0.38
31
230
26
153
1.73
1.82
2.1
2.5
3.1
3.2
g/l
0.04
19
126
64
465
1.42
1.81
9.1
7.8
0.6
1.1
mmol/l
0.36
53
361
211
1819
1.24
1.74
4.4
3.9
—
—
—
0
0
28
171
1.67
1.73
4.5
5.0
1.7
1.5
%
0.65
28
157
30
187
1.63
1.71
1.1
1.2
260.2
171.1
iu/ml
0.21
14
70
123
997
1.29
1.71
3.0
3.0
0.8
0.8
ug/l
0.03
90
665
381
3497
1.22
1.69
19.1
13.9
74.3
77.7
ml/min/173m2
1.85
314
2860
53
378
1.44
1.67
10.0
8.8
117.7
120.1
g/l
0.33
53
358
23
135
1.73
1.64
2.3
2.8
—
—
—
0
0
395
3647
1.22
1.62
4.9
4.3
4.4
4.6
mmol/l
3.50
360
3348
402
3722
1.22
1.59
5.6
4.8
2.6
2.7
mmol/l
2.48
365
3396
62
461
1.38
1.56
1.9
1.7
—
—
—
0
0
26
161
1.64
1.54
2.1
2.4
3.9
3.7
g/l
0.46
19
124
26
161
1.64
1.54
2.1
2.4
8.0
7.3
g/l
0.73
20
130
26
161
1.64
1.54
2.1
2.4
—
—
—
0
0
5
15
3.35
1.52
1.6
2.9
—
—
—
0
0
5
15
3.35
1.52
1.6
2.9
—
—
—
0
0
6
21
2.87
1.50
1.3
1.4
—
—
—
0
0
36
243
1.51
1.50
1.4
1.4
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
23
140
1.67
1.46
2.5
2.3
0.3
0.4
u/ml
—
10
74
51
374
1.39
1.40
3.1
2.9
282.1
201.6
ng/l
0.85
46
347
24
150
1.62
1.39
2.1
2.3
10.6
10.1
g/l
0.20
18
133
389
3618
1.19
1.36
4.8
4.3
1.4
1.4
mmol/l
1.68
349
3310
96
780
1.27
1.33
4.2
4.1
242.5
314.9
ng/l
0.28
82
640
60
459
1.34
1.29
1.9
1.8
—
—
—
0
0
26
170
1.55
1.27
1.5
1.9
1.9
1.9
ug/l
0.01
21
146
228
2040
1.18
1.22
2.8
2.8
—
—
—
0
0
375
3509
1.17
1.12
4.3
3.9
1.3
1.3
mmol/l
0.04
334
3194
7
32
2.20
1.08
1.4
1.4
—
—
—
0
0
363
3394
1.16
1.07
20.9
16.0
38.3
39.5
%
1.37
234
2355
33
237
1.41
1.06
4.4
3.7
2.4
1.8
mmol/l
0.27
23
176
34
247
1.40
1.03
6.9
6.3
24.4
24.5
mmol/l
0.05
34
224
111
949
1.20
0.99
3.8
2.6
11795.4
11293.8
umol/l
0.03
94
815
5
23
2.18
0.98
1.2
1.5
—
—
—
0
0
257
2368
1.14
0.89
3.1
3.1
58.5
50.8
u/l
0.66
244
2194
6
30
2.01
0.87
1.3
1.7
—
—
—
0
0
6
30
2.01
0.87
1.3
1.7
—
—
—
0
0
6
30
2.01
0.87
1.3
1.7
—
—
—
0
0
386
3657
1.14
0.86
5.4
4.4
6.2
6.0
mmol/l
2.30
344
3299
14
88
1.60
0.84
1.1
1.4
—
—
—
0
0
16
106
1.52
0.79
1.9
1.4
219.5
254.2
ug/g
0.33
11
60
12
75
1.61
0.75
1.2
1.7
—
—
—
0
0
5
24
2.09
0.74
2.2
2.5
13.5
13.2
%
—
5
24
7
39
1.80
0.72
1.1
1.2
—
—
—
0
0
13
84
1.56
0.72
2.0
1.5
14731.5
13369.4
e6/l
—
8
56
7
40
1.76
0.71
1.3
1.5
—
—
—
0
0
5
27
1.86
0.68
1.2
1.3
—
—
—
0
0
5
27
1.86
0.68
1.2
1.3
—
—
—
0
0
5
27
1.86
0.68
1.0
1.6
14.4
18.4
u/l
—
5
22
79
683
1.18
0.66
3.6
3.1
2.1
1.2
e6/l
0.52
45
394
5
29
1.73
0.64
1.2
1.4
—
—
—
0
0
44
532
0.81
0.64
1.3
1.3
14.2
13.0
u/ml
0.05
21
198
74
640
1.18
0.62
4.0
3.2
2.2
2.2
e6/l
0.01
39
356
10
63
1.60
0.62
4.1
3.1
58.2
58.6
%
—
10
63
10
149
0.67
0.57
1.7
1.3
—
—
—
0
0
6
36
1.67
0.56
1.2
1.3
—
—
—
0
0
13
90
1.45
0.55
1.8
1.3
—
—
—
0
0
47
395
1.20
0.55
1.9
1.8
1.4
1.5
%
0.35
42
347
6
38
1.58
0.54
2.0
2.7
—
—
—
0
0
21
267
0.78
0.49
1.5
1.8
—
—
—
0
0
16
119
1.35
0.48
1.9
1.2
—
—
—
0
0
13
93
1.40
0.48
1.1
1.5
—
—
—
0
0
10
68
1.48
0.47
1.7
1.6
—
—
—
0
0
32
266
1.21
0.44
2.1
1.6
—
—
—
0
0
20
157
1.28
0.43
2.0
1.7
—
—
—
0
0
43
498
0.85
0.43
1.3
1.5
—
—
—
0
0
5
32
1.57
0.42
1.2
1.5
—
—
—
0
0
5
32
1.57
0.42
1.0
1.0
—
—
—
0
0
10
70
1.43
0.41
1.2
1.7
—
—
—
0
0
0
15
0.00
0.41
0.0
3.6
—
14.0
—
0
9
0
16
0.00
0.41
0.0
1.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
3.6
—
—
—
0
0
19
237
0.79
0.40
1.6
1.7
—
—
—
0
0
41
472
0.86
0.39
4.8
4.4
32.3
31.4
%
0.17
28
307
31
261
1.20
0.38
1.6
1.6
—
—
—
0
0
97
890
1.10
0.37
1.9
1.6
19.2
20.5
nmol/l
0.45
83
752
21
171
1.23
0.36
2.0
1.9
—
—
—
0
0
31
264
1.18
0.35
3.6
2.9
125.8
128.1
g/l
0.24
31
257
19
154
1.24
0.34
1.1
1.0
—
—
—
0
0
11
83
1.33
0.32
1.5
1.3
—
—
—
0
0
7
99
0.70
0.31
3.4
1.8
—
—
—
0
0
7
55
1.27
0.30
1.0
1.1
—
—
—
0
0
7
57
1.23
0.29
1.4
1.6
—
—
—
0
0
7
57
1.23
0.29
1.4
1.2
—
—
—
0
0
8
63
1.27
0.28
1.1
1.1
—
—
—
0
0
8
64
1.25
0.27
1.5
1.3
—
—
—
0
0
42
376
1.12
0.27
1.3
1.4
—
—
—
0
0
101
949
1.08
0.25
2.9
2.2
—
—
—
0
0
5
40
1.25
0.22
5.4
3.6
4.2
7.5
nmol/l
—
5
40
5
40
1.25
0.22
1.2
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
8
101
0.79
0.21
1.4
1.2
—
—
—
0
0
8
101
0.79
0.21
1.4
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.3
—
8.8
—
0
12
12
98
1.23
0.21
1.3
1.5
0.1
0.1
iu/ml
—
5
20
12
98
1.23
0.21
1.4
1.6
—
—
—
0
0
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.7
—
—
—
0
0
6
51
1.18
0.19
1.0
1.5
—
—
—
0
0
6
51
1.18
0.19
1.2
1.8
—
—
—
0
0
6
52
1.15
0.19
1.0
1.6
—
—
—
0
0
6
52
1.15
0.19
1.0
1.6
—
—
—
0
0
6
52
1.15
0.19
1.0
1.6
—
—
—
0
0
6
53
1.13
0.18
1.0
1.5
—
—
—
0
0
6
53
1.13
0.18
1.0
1.5
—
—
—
0
0
52
483
1.08
0.18
9.9
7.0
—
—
—
0
0
7
61
1.15
0.17
1.1
1.4
70.4
149.3
pmol/l
—
7
61
8
72
1.11
0.16
1.3
1.4
—
—
—
0
0
11
126
0.87
0.11
1.5
1.8
53.5
38.3
nmol/l
0.92
11
121
5
47
1.06
0.09
1.4
1.7
—
—
—
0
0
10
112
0.89
0.07
1.8
1.7
—
—
—
0
0
9
86
1.05
0.07
1.6
1.3
—
—
—
0
0
9
86
1.05
0.07
1.6
1.3
—
—
—
0
0
9
87
1.03
0.07
1.8
1.7
—
—
—
0
0
52
538
0.96
0.07
1.3
1.3
29.4
40.1
iu/ml
0.57
16
164
8
93
0.86
0.06
1.0
1.1
—
15.7
—
0
12
9
100
0.90
0.06
1.4
1.6
—
—
—
0
0
11
119
0.92
0.04
1.5
1.5
—
96.0
—
0
5
33
339
0.97
0.02
2.4
2.2
10.8
12.7
nmol/l
0.71
27
297
96
968
0.99
0.01
1.9
1.6
1.3
1.4
mmol/l
0.57
84
809
10
97
1.03
0.00
1.8
1.5
—
—
—
0
0
42
424
0.99
0.00
2.9
4.1
5.9
21.6
ug/l
0.74
36
361
0
5
0.00
0.00
0.0
1.0
—
93.4
—
0
5
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
55
0.91
0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
6
62
0.97
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.2
1.5
—
—
—
0
0
5
53
0.94
0.00
1.2
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
0.3
—
0
8
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
9
90
1.00
0.00
1.8
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
2.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
2.5
3.4
160.7
18.4
u/ml
—
6
61
Mortality – FinRegistry
↥Association
Association between endpoint H7_APHAKIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_APHAKIA | 1.166 [1.01, 1.34] | 0.033 |
| Birth year | 0.994 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 474 out of 1272 females with H7_APHAKIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_APHAKIA | 1.201 [1.03, 1.4] | 0.021 |
| Birth year | 0.985 [0.97, 1.0] | 0.009 |
During the follow-up period (1.1.1998 — 31.12.2019), 451 out of 1466 males with H7_APHAKIA died.
Mortality risk
Mortality risk for people of age
years, who have H7_APHAKIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.09% | 0.206% |
| 5 | 0.591% | 1.283% |
| 10 | 1.564% | 3.269% |
| 15 | 2.999% | 6.2% |
| 20 | 5.598% | 10.411% |
Relationships between endpoints
↥Index endpoint: H7_APHAKIA – Aphakia
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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