Spinal osteochondrosis

M13_SPINALOSTEOCHON

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 M42
  • Hospital discharge: ICD-9 7320
  • Cause of death: ICD-10 M42
  • Cause of death: ICD-9 7320

2 out of 7 registries used, show all original rules.

437

4. Check minimum number of events

None

437

5. Include endpoints

None

437

6. Filter based on genotype QC (FinnGen only)

422

Control definitions (FinnGen only)

Control exclude
M13_DORSOPATHY

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
M40-M43
Name in latin
Osteochondrosis spinalis

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4271 1626 2630
Only index persons 4030 1537 2493
Unadjusted period prevalence (%)
Whole population 0.06 0.05 0.07
Only index persons 0.08 0.06 0.10
Median age at first event (years)
Whole population 35.52 48.47 27.38
Only index persons 33.50 46.39 25.56

-FinnGen-

Key figures

All Female Male
Number of individuals 422 195 227
Unadjusted period prevalence (%) 0.09 0.07 0.10
Median age at first event (years) 40.63 42.99 38.61

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
437
Matched controls
4370
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
M42.0
ICD-10 Finland
Juvenile osteochondrosis of spine
7223.5
301.5
255
*
M51.1
ICD-10 Finland
Lumbar and other intervertebral disc disorders with radiculopathy
70.9
221.2
123
24
M48.0
ICD-10 Finland
Spinal stenosis
99.6
202.5
106
14
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
58.4
148.7
85
18
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
40.2
143.2
90
28
M42.1
ICD-10 Finland
Adult osteochondrosis of spine
+∞
96.5
89
*
N03AX16
ATC
[U] pregabalin
8.0
91.5
163
303
N03AX12
ATC
[U] gabapentin; oral
9.2
83.7
120
173
M54.9
ICD-10 Finland
Dorsalgia, unspecified
10.2
80.7
103
128
M54.5
ICD-10 Finland
Low back pain
6.1
79.4
223
634
M54.4
ICD-10 Finland
Lumbago with sciatica
8.2
71.6
112
177
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
9.6
68.1
89
113
N02AX02
ATC
tramadol; systemic, rectal
4.9
59.7
241
883
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
12.1
59.0
63
60
M54.6
ICD-10 Finland
Pain in thoracic spine
10.5
58.8
70
78
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
22.6
57.3
43
21
M42.9
ICD-10 Finland
Spinal osteochondrosis, unspecified
+∞
56.5
53
*
ABC36
NOMESCO Finland
Decompression of lumbar nerve roots
307.5
54.5
54
*
7320A
ICD-9 Finland
Osteochondropathies, Juvenile osteochondrosis of spine[MORBUS SCHEUERMANN]
+∞
53.2
50
*
N06AX21
ATC
duloxetine; oral
6.3
46.3
88
167
M47.2
ICD-10 Finland
Other spondylosis with radiculopathy
110.1
45.8
49
5
M03BC01
ATC
orphenadrine (citrate); systemic
4.2
40.6
141
441
M54.3
ICD-10 Finland
Sciatica
11.8
36.9
39
36
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
14.9
35.1
32
23
L03
ICPC
Low back symptom/complaint
3.6
32.0
146
541
M03BX02
ATC
tizanidine; oral
3.4
31.4
306
1772
M47.9
ICD-10 Finland
Spondylosis, unspecified
172.2
31.1
32
*
M47.82
ICD-10 Finland
Other spondylosis, cervical region
44.8
30.4
37
9
L02
ICPC
Back symptom/complaint
4.8
30.4
77
186
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
3.0
27.9
226
1153
M01AH01
ATC
celecoxib; oral
3.9
27.4
94
285
M79.6
ICD-10 Finland
Pain in limb
3.0
27.1
203
989
NA7EA
NOMESCO Finland
Scoliosis X-ray examination
149.2
26.9
28
*
M53.1
ICD-10 Finland
Cervicobrachial syndrome
4.7
25.7
65
156
M43.1
ICD-10 Finland
Spondylolisthesis
38.2
25.6
32
9
N06AA09
ATC
amitriptyline; systemic
5.3
25.6
55
115
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
59.6
24.3
28
5
M47.80
ICD-10 Finland
Other spondylosis, multiple sites in spine
40.1
24.3
30
8
L86
ICPC
Back syndrome with radiating pain
7.5
24.1
36
52
M50.1
ICD-10 Finland
Cervical disc disorder with radiculopathy
35.7
23.7
30
9
NAG62
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, 2-3 vertebraea
+∞
23.1
22
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.9
22.2
136
584
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
22.1
119
475
M40.2
ICD-10 Finland
Other and unspecified kyphosis
+∞
22.1
21
*
NA3EA
NOMESCO Finland
Lumbar spine X-ray examination with flexion
84.6
21.9
24
*
N02BF02
ATC
pregabalin; oral
6.3
21.7
38
65
M01AH02
ATC
rofecoxib; oral
4.1
21.7
66
182
M54.2
ICD-10 Finland
Cervicalgia
5.1
21.1
47
101
R51.80
ICD-10 Finland
Headache
3.3
21.0
95
341
NAG40
NOMESCO Finland
Anterior fusion of cervical spine without fixation
+∞
21.0
20
*
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
23.8
20.7
29
13
R52.2
ICD-10 Finland
Other chronic pain
8.4
20.2
27
34
M01AE03
ATC
ketoprofen; systemic, rectal
2.6
20.1
167
832
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.5
20.1
53
131
A02BC05
ATC
esomeprazole; systemic
2.6
20.1
188
992
ABC16
NOMESCO Finland
Microsurgical excision of lumbar intervertebral disc displacement
+∞
19.9
19
*
N06AX11
ATC
mirtazapine; oral
2.6
19.7
168
846
M01AH05
ATC
etoricoxib; oral
2.6
19.7
281
1799
M01AB55
ATC
diclofenac, combinations; oral
6.0
19.3
35
62
A02BC02
ATC
pantoprazole; systemic
2.6
19.2
294
1935
N02AJ06
ATC
codeine and paracetamol; systemic
2.5
18.6
198
1099
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.5
18.5
173
905
R07.4
ICD-10 Finland
Chest pain, unspecified
2.7
18.4
126
567
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
6.6
18.2
30
48
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.7
18.2
124
556
G47.3
ICD-10 Finland
Sleep apnoea
2.7
18.0
124
558
N02BF01
ATC
gabapentin; oral
5.2
17.9
38
78
Z50.1
ICD-10 Finland
Other physical therapy
5.4
17.5
36
72
N06CA01
ATC
amitriptyline and psycholeptics; systemic
4.0
16.8
51
140
A01
ICPC
Pain general/multiple sites
3.9
16.7
52
145
M54.1
ICD-10 Finland
Radiculopathy
18.8
16.7
25
14
ABC56
NOMESCO Finland
Decompression of lumbar spinal canal and nerve roots
176.5
16.6
17
*
R53
ICD-10 Finland
Malaise and fatigue
2.6
16.2
118
543
SPAT1301
SPAT
No procedures
2.4
16.0
145
739
N06AX16
ATC
venlafaxine; oral
3.0
16.0
82
314
L28
ICPC
Limited function/disability (L)
3.2
16.0
72
256
R06.0
ICD-10 Finland
Dyspnoea
2.6
15.9
121
569
SPAT1097
SPAT
Recording of ECG
3.2
15.7
71
253
A02BC01
ATC
omeprazole; systemic
2.5
15.4
118
555
G44.2
ICD-10 Finland
Tension-type headache
3.1
15.4
70
250
R03AC02
ATC
salbutamol; inhalant
2.3
15.2
254
1667
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
15.0
99
432
N02BE01
ATC
paracetamol; systemic, rectal
3.3
14.9
390
3115
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.1
14.8
43
114
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
3.0
14.7
72
268
G55.1*M51.1
ICD-10 Finland
Compression of nerve roots and nerve plexus in disc diseases in the lumbar region and other regions
83.0
14.7
16
*
M50.3
ICD-10 Finland
Other cervical disc degeneration
37.4
14.5
18
5
N05AH04
ATC
quetiapine; oral
2.6
14.5
99
439
M01AE02
ATC
naproxen; oral, rectal
2.2
14.3
258
1728
F45.4
ICD-10 Finland
Persistent somatoform pain disorder
23.2
14.3
20
9
R42
ICD-10 Finland
Dizziness and giddiness
2.6
14.3
96
422
N05CF01
ATC
zopiclone; oral
2.3
14.2
145
772
M01AX17
ATC
nimesulide; oral
2.6
14.1
98
438
M01AB05
ATC
diclofenac; systemic, rectal
2.2
14.0
285
1998
A02BC03
ATC
lansoprazole; oral
2.4
13.7
123
618
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
6.1
13.7
24
41
NAG53
NOMESCO Finland
Posterior or lateral fusion of thoracic spine with fixation, more than 3 vertebraea
+∞
13.6
13
*
UJF32
NOMESCO Finland
Coloscopy
2.5
13.6
108
514
J01AA02
ATC
doxycycline; systemic
2.3
13.5
327
2442
L01
ICPC
Neck symptom/complaint
2.8
13.5
75
299
M19.0
ICD-10 Finland
Primary arthrosis of other joints
3.5
13.0
48
150
M75.1
ICD-10 Finland
Rotator cuff syndrome
2.4
12.9
105
504
M03BC51
ATC
orphenadrine, combinations; systemic
2.3
12.8
119
605
G56.0
ICD-10 Finland
Carpal tunnel syndrome
3.0
12.8
61
223
NA3AD
NOMESCO Finland
Lumbar spine and sacrum CT examination
18.0
12.6
19
11
M47.81
ICD-10 Finland
Other spondylosis, occipito-atlanto-axial region
+∞
12.6
12
*
ABC26
NOMESCO Finland
Open discectomy of lumbar spine
+∞
12.6
12
*
M01AC06
ATC
meloxicam; systemic, rectal
2.2
12.6
147
822
C07AA05
ATC
propranolol; systemic
2.4
12.5
106
518
M25.5
ICD-10 Finland
Pain in joint
2.2
12.4
137
747
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.4
12.4
102
491
A07EC01
ATC
sulfasalazine; oral, rectal
3.9
12.4
37
100
N02AA05
ATC
oxycodone; systemic
2.8
12.4
69
275
H02AB06
ATC
prednisolone; systemic
2.1
12.4
197
1238
NA1EA
NOMESCO Finland
Cervical spine X-ray examination with flexion
38.7
12.3
15
*
NA1AA
NOMESCO Finland
Cervical spine X-ray examination without contrast
11.5
12.2
22
20
M79.1
ICD-10 Finland
Myalgia
2.7
11.9
74
312
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.3
11.8
105
522
M41.9
ICD-10 Finland
Scoliosis, unspecified
31.0
11.7
15
5
WX704
NOMESCO Finland
Intubation
3.5
11.7
42
129
M45
ICD-10 Finland
Ankylosing spondylitis
66.8
11.7
13
*
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
66.8
11.7
13
*
M43.0
ICD-10 Finland
Spondylolysis
66.8
11.7
13
*
M54
ICD-10 Finland
Dorsalgia
2.9
11.6
59
223
N03AE01
ATC
clonazepam; systemic
4.1
11.6
33
86
7227C
ICD-9 Finland
Intervertebral disk disorders, Intervertebral disk disorder with myelopathy[SYNDROMA ISCHIADICUM]
+∞
11.5
11
*
M51.9
ICD-10 Finland
Intervertebral disc disorder, unspecified
123.1
11.5
12
*
SPAT1263
SPAT
Sampling
2.0
11.5
182
1134
WX720
NOMESCO Finland
Own respiration
4.7
11.4
27
61
R52.9
ICD-10 Finland
Pain, unspecified
3.2
11.3
47
158
N06AB04
ATC
citalopram; systemic
2.4
11.3
95
460
WX110
NOMESCO Finland
Infiltration anesthesia
2.1
11.3
318
2426
C07AB07
ATC
bisoprolol; oral
2.0
11.1
182
1143
N06AX03
ATC
mianserin; oral
4.8
11.1
25
54
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.6
11.0
69
292
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
10.9
113
597
A02BA02
ATC
ranitidine; systemic
2.4
10.6
79
362
R01AD08
ATC
fluticasone; nasal
2.1
10.6
130
734
M47.1
ICD-10 Finland
Other spondylosis with myelopathy
+∞
10.5
10
*
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
+∞
10.5
10
*
R02
ICPC
Shortness of breath/dyspnoea
2.8
10.4
56
218
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
3.0
10.4
50
183
WX725
NOMESCO Finland
Noninvasive ventilation
4.1
10.2
28
71
K30
ICD-10 Finland
Functional dyspepsia
2.8
10.2
53
203
Z3226
NOMESCO Finland
Physiotherapist
2.4
10.2
78
362
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.0
10.1
134
776
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
10.1
178
1140
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.4
10.0
76
351
M79.0
ICD-10 Finland
Rheumatism, unspecified
9.1
9.9
20
23
M77.1
ICD-10 Finland
Lateral epicondylitis
3.2
9.8
40
133
N04BC05
ATC
pramipexole; oral
3.5
9.8
35
107
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.6
9.8
63
269
J01DB01
ATC
cefalexin; oral
2.3
9.8
362
2969
J45.9
ICD-10 Finland
Asthma, unspecified
2.3
9.6
81
392
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
9.5
62
266
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.4
9.5
35
109
SPAT1240
SPAT
Therapeutic discussion
2.6
9.5
60
254
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.9
9.4
170
1091
7245A
ICD-9 Finland
Other and unspecified disorders of back, Backache, unspecified
+∞
9.4
9
*
M41.1
ICD-10 Finland
Juvenile idiopathic scoliosis
+∞
9.4
9
*
M41.2
ICD-10 Finland
Other idiopathic scoliosis
+∞
9.4
9
*
NE1BG
NOMESCO Finland
Pelvic, hip and femur MRI examination with high intensity magnet
9.0
9.4
19
22
J31.0
ICD-10 Finland
Chronic rhinitis
2.9
9.2
46
172
G43.9
ICD-10 Finland
Migraine, unspecified
3.5
9.2
33
101
Z04.9
ICD-10 Finland
Examination and observation for unspecified reason
4.6
9.2
22
50
A07AA02
ATC
nystatin; oral
4.1
9.2
25
63
ZXM10
NOMESCO Finland
Intraoperative use of conventional X-ray imaging
3.8
9.1
28
77
SPAT1153
SPAT
Removal of sutures
2.0
9.1
121
698
WX702
NOMESCO Finland
Supraglottic ventilation device
3.4
9.1
33
102
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
2.0
9.0
126
739
M02AA10
ATC
ketoprofen; topical
2.5
9.0
63
280
A02BA04
ATC
nizatidine; systemic
3.6
8.9
30
88
C03CA01
ATC
furosemide; systemic
2.1
8.9
99
534
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.5
8.8
61
270
WX402
NOMESCO Finland
General anaesthesia
2.1
8.7
90
471
G54.0
ICD-10 Finland
Brachial plexus disorders
14.4
8.7
14
10
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.8
8.7
204
1414
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
2.8
8.7
46
178
UJD02
NOMESCO Finland
Gastroscopy
4.0
8.6
25
66
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.0
8.6
40
144
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.8
8.5
237
1725
G55.2*M47.9
ICD-10 Finland
Nerve root and plexus compressions in spondylosis
28.1
8.5
11
*
R1250
NOMESCO Finland
Evaluation of functional capability
8.1
8.4
18
23
J45
ICD-10 Finland
Asthma
2.8
8.4
43
163
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
2.7
8.4
48
193
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.3
8.4
66
309
NAG63
NOMESCO Finland
Posterior fusion of lumbar spine with fixation, more than 3 vertebraea
+∞
8.4
8
*
M40.1
ICD-10 Finland
Other secondary kyphosis
+∞
8.4
8
*
H05BA01
ATC
calcitonin (salmon synthetic); nasal, parenteral
9.7
8.3
16
17
N05BA04
ATC
oxazepam; oral
2.0
8.3
109
623
R03BB04
ATC
tiotropium bromide; inhalant
3.0
8.3
37
130
M70.6
ICD-10 Finland
Trochanteric bursitis
2.7
8.2
44
171
N05AF03
ATC
chlorprothixene; systemic
4.9
8.2
18
38
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.2
8.2
32
104
M75.4
ICD-10 Finland
Impingement syndrome of shoulder
3.3
8.1
31
99
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.8
8.1
227
1647
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.3
8.1
21
51
L84
ICPC
Back syndrome without radiat pain
3.8
8.0
24
65
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.2
8.0
72
357
N05CD07
ATC
temazepam; oral
2.6
8.0
47
192
J01DA01
ATC
[U] cefalexin
1.8
7.9
257
1941
M01AH03
ATC
valdecoxib; oral
3.6
7.9
26
75
R20.2
ICD-10 Finland
Paraesthesia of skin
3.2
7.9
32
106
R55
ICD-10 Finland
Syncope and collapse
2.6
7.9
46
187
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
7.9
53
231
M16.1
ICD-10 Finland
Other primary coxarthrosis
2.7
7.9
44
175
ZZH21
NOMESCO Finland
Graft of patients own bone, small pieces
11.1
7.8
14
13
N02AJ13
ATC
tramadol and paracetamol; systemic
9.7
7.8
15
16
R01AD09
ATC
mometasone; nasal
1.8
7.8
190
1319
H04.10
ICD-10 Finland
Dry eye syndrome
2.6
7.8
47
194
M01AB08
ATC
etodolac; oral
3.1
7.8
32
107
SPAT1284
SPAT
Extensive health certificate
6.1
7.8
20
34
A11
ICPC
Chest pain NOS
2.9
7.8
37
135
J01FA10
ATC
azithromycin; systemic
1.8
7.7
250
1882
K02.1
ICD-10 Finland
Caries of dentine
1.8
7.7
261
1991
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
7.7
85
456
L04
ICPC
Chest symptom/complaint
3.0
7.7
34
119
N05BA01
ATC
diazepam; systemic, rectal
2.4
7.6
58
267
M54.8
ICD-10 Finland
Other dorsalgia
6.4
7.6
19
31
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.7
7.6
41
160
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.0
7.6
103
595
F34.1
ICD-10 Finland
Dysthymia
3.7
7.5
24
68
N06AB05
ATC
paroxetine; oral
3.1
7.5
31
104
ACC59
NOMESCO Finland
Decompression and freeing of adhesions of peripheral nerve: other or unspecified
4.5
7.5
18
41
M13.9
ICD-10 Finland
Arthritis, unspecified
3.1
7.4
32
110
G55.1*M51.9
ICD-10 Finland
Nerve root and plexus compressions in intervertebral disc disorders (M50-M51+)
81.4
7.4
8
*
ABD32
NOMESCO Finland
Implantation of temporary spinal stimulation device
81.4
7.4
8
*
SAA02
NOMESCO Finland
Basic examination of mouth
1.8
7.4
290
2295
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.1
7.4
73
375
R01BA52
ATC
pseudoephedrine, combinations; oral
1.9
7.4
113
679
SPAT1310
SPAT
Counselling related to known health issue
1.8
7.3
129
810
7225A
ICD-9 Finland
Intervertebral disk disorders, Degeneration of thoracic or lumbar intervertebral disk[DEGENERATIO DISCI INTERVERTEBRALIS THORAC SEU LUMB]
+∞
7.3
7
*
NAG65
NOMESCO Finland
Anterior and posterior fusion of lumbar spine
+∞
7.3
7
*
M96.1
ICD-10 Finland
Postlaminectomy syndrome, not elsewhere classified
+∞
7.3
7
*
R51.81
ICD-10 Finland
Facial pain NOS
7.5
7.2
16
22
N05BA12
ATC
alprazolam; oral
2.5
7.2
49
214
P03
ICPC
Feeling depressed
2.4
7.2
49
215
H01
ICPC
Ear pain/earache
2.3
7.1
55
255
M35.7
ICD-10 Finland
Hypermobility syndrome
12.3
7.1
12
10
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.3
7.1
27
86
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.6
7.1
43
178
Z3231
NOMESCO Finland
Registered nurse
1.9
7.1
113
687
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.7
7.1
38
148
A01AB09
ATC
miconazole; local oral
2.7
7.1
38
148
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
2.9
7.1
33
119
R13
ICD-10 Finland
Dysphagia
3.1
7.1
29
97
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
3.2
7.0
28
92
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.9
6.9
111
675
ZXA00
NOMESCO Finland
Right side
1.9
6.9
98
573
205
Kela drug reimbursment
Chronic hypertension
2.0
6.9
91
519
R03AC03
ATC
terbutaline; inhalant
2.2
6.9
62
307
UKC02
NOMESCO Finland
Cystoscopy
2.3
6.8
54
253
R52.1
ICD-10 Finland
Chronic intractable pain
40.7
6.8
8
*
C07AB02
ATC
metoprolol; systemic
2.1
6.8
68
351
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.5
6.8
45
195
SFA10
NOMESCO Finland
One-surface restoration
1.7
6.7
235
1781
M17.0
ICD-10 Finland
Primary gonarthrosis, bilateral
2.4
6.7
48
215
N06AB10
ATC
escitalopram; oral
1.9
6.7
95
555
C01DA14
ATC
isosorbide mononitrate; oral
2.4
6.7
47
209
C10AA03
ATC
pravastatin; oral
3.0
6.7
30
106
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.6
6.6
39
159
H02AB04
ATC
methylprednisolone; systemic
2.3
6.6
53
250
R4110, ,
SPAT
2.7
6.5
36
142
SPAT1254
SPAT
Administration of medicine
2.2
6.5
61
306
R01AD12
ATC
fluticasone furoate; nasal
1.8
6.5
134
877
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
6.5
90
521
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
6.5
308
2523
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.0
6.5
71
379
M53.2
ICD-10 Finland
Spinal instabilities
70.8
6.4
7
*
M54.0
ICD-10 Finland
Panniculitis affecting regions of neck and back
14.6
6.4
10
7
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
2.2
6.4
59
294
A06AD11
ATC
lactulose; oral
2.3
6.4
50
233
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
6.4
75
410
N05CF02
ATC
zolpidem; oral
2.1
6.4
68
359
M75.8
ICD-10 Finland
Other shoulder lesions
3.6
6.4
21
61
J01FA09
ATC
clarithromycin; systemic
1.8
6.3
125
807
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.0
6.3
72
389
P01
ICPC
Feeling anxious/nervous/tense
2.1
6.3
62
317
L13
ICPC
Hip symptom/complaint
2.1
6.3
59
296
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
2.2
6.3
54
262
72870
ICD-8 Finland
Vertebrogenic pain syndrome, Lumbalgia
+∞
6.3
6
*
AB5BT
NOMESCO Finland
Blockage of nerv root with X-ray guidance
+∞
6.3
6
*
M40.0
ICD-10 Finland
Postural kyphosis
+∞
6.3
6
*
M42
ICD-10 Finland
Spinal osteochondrosis
+∞
6.3
6
*
L02.4
ICD-10 Finland
Cutaneous abscess, furuncle and carbuncle of limb
3.3
6.2
23
72
M53.0
ICD-10 Finland
Cervicocranial syndrome
2.5
6.2
38
158
L12
ICPC
Hand/finger symptom/complaint
2.1
6.2
63
326
N03AF01
ATC
carbamazepine; oral, rectal
3.4
6.2
22
67
X59
ICD-10 Finland
Exposure to unspecified factor
1.9
6.2
81
459
D01AC02
ATC
miconazole; topical
2.7
6.2
34
134
SPAT1249
SPAT
Treatment-related counselling outside office
1.7
6.2
150
1026
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
3.1
6.2
25
83
Z3229
NOMESCO Finland
Other healthcare associate professional
2.5
6.2
39
165
M02AA07
ATC
piroxicam; topical
1.8
6.2
125
813
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
7.8
6.2
13
17
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.2
6.1
16
39
N30.9
ICD-10 Finland
Cystitis, unspecified
3.2
6.1
24
78
ZXE20
NOMESCO Finland
More than three and less than five hours
2.2
6.1
52
251
K04.1
ICD-10 Finland
Necrosis of pulp
2.2
6.1
52
251
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.7
6.1
128
840
G04BD08
ATC
solifenacin; oral
3.0
6.1
26
89
L01BA01
ATC
methotrexate; systemic
6.2
6.0
15
25
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
3.2
6.0
24
79

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
158
816
2.47
17.12
2.4
2.1
210.56
242.01
u/l
0.29
149
770
324
2298
2.59
17.02
5.6
3.4
10.76
10.52
mm/h
0.12
310
2102
336
2436
2.64
16.64
4.3
3.5
14.92
14.73
pmol/l
0.70
313
2207
111
490
2.70
16.62
1.4
1.2
20.40
29.00
iu/ml
0.60
31
158
212
1292
2.24
15.23
13.1
12.0
1.31
1.23
inr
0.56
50
387
101
452
2.61
14.55
1.3
1.2
2.94
9.10
u/ml
1.57
43
172
157
873
2.25
13.82
2.7
2.4
50.88
62.11
u/l
1.31
146
813
246
1635
2.15
13.73
7.3
5.9
1.95
1.98
e9/l
0.10
229
1474
113
553
2.41
13.34
1.8
1.7
406.10
8457076.88
pmol/l
0.50
96
473
244
1636
2.11
13.07
8.5
6.4
0.20
0.18
e9/l
0.99
225
1457
238
1583
2.11
13.00
7.4
5.9
0.04
0.04
e9/l
1.48
215
1388
237
1581
2.09
12.77
7.4
5.9
0.56
0.57
e9/l
0.10
214
1384
113
563
2.36
12.76
2.9
2.6
5.41
5.15
e6/l
0.07
103
508
275
1948
2.11
12.50
5.7
3.6
88.86
836.20
e6/l
—
7
30
253
1739
2.08
12.45
5.2
4.6
6.53
6.69
mmol/l
0.58
239
1608
95
443
2.46
12.40
1.9
1.6
1020.05
1147.18
nmol/l
0.83
76
338
174
1045
2.11
12.31
4.0
3.2
32.23
40.67
ng/l
0.45
116
664
215
1398
2.06
12.25
7.3
6.5
1.22
1.21
mmol/l
1.34
196
1199
226
1497
2.06
12.24
7.8
6.2
—
—
—
0
0
180
1102
2.08
12.04
2.2
1.7
94.06
96.29
pmol/l
0.22
95
568
316
2380
2.18
11.96
8.2
7.0
74.85
77.61
u/l
0.85
301
2227
374
3028
2.63
11.86
5.4
4.1
1.79
2.25
mu/l
0.59
356
2775
37
105
3.76
11.56
2.9
2.5
—
—
—
0
0
221
1473
2.01
11.54
3.9
3.0
0.00
0.00
estimate
-0.00
36
299
289
2122
2.07
11.45
5.9
3.6
—
—
—
0
0
222
1485
2.01
11.45
3.9
3.0
0.00
0.01
estimate
0.50
32
263
191
1213
2.02
11.39
3.9
2.9
5.50
5.85
ph
—
8
113
189
1201
2.01
11.21
5.4
4.8
36.65
36.31
g/l
0.41
176
1122
228
1549
1.99
11.15
5.6
6.3
10.20
11.89
umol/l
1.68
218
1479
123
670
2.16
11.02
2.5
2.0
2.74
2.99
mg/l
0.72
108
579
219
1479
1.96
10.78
5.7
4.2
0.00
0.00
estimate
-0.00
30
284
400
3393
3.11
10.75
19.3
11.1
17.69
24.46
mg/l
5.57
332
2589
227
1564
1.94
10.41
8.2
5.8
29.48
28.52
%
0.75
218
1488
255
1832
1.94
10.26
10.6
9.6
4.13
3.98
e9/l
0.49
231
1608
36
110
3.48
10.09
1.1
1.1
—
—
—
0
0
85
418
2.28
9.68
2.4
2.3
13.43
14.04
umol/l
0.32
79
388
118
664
2.06
9.55
1.6
1.6
0.92
1.13
mg/l
0.53
89
486
218
1513
1.88
9.49
8.6
6.0
8.05
8.60
%
2.29
207
1434
217
1504
1.88
9.48
8.1
5.8
2.94
2.86
%
0.20
207
1421
163
1032
1.92
9.39
4.2
3.4
91.26
149.69
e6/l
0.31
126
684
185
1223
1.89
9.33
2.8
2.1
73.21
75.02
nmol/l
0.40
177
1115
220
1539
1.86
9.27
7.9
5.6
56.46
56.56
%
0.05
212
1466
143
872
1.95
9.18
3.4
3.0
17.44
87.98
e6/l
2.72
116
647
169
1092
1.89
9.09
4.2
3.5
30.34
33.41
u/l
0.84
153
1044
413
3634
3.49
9.06
17.1
10.4
—
—
—
0
0
209
1449
1.85
8.97
8.2
5.8
0.68
0.68
%
0.01
197
1363
112
636
2.02
8.76
4.2
3.2
1.02
1.02
kg/l
0.07
14
83
122
716
1.98
8.69
3.1
3.3
2218.30
1360.69
ng/l
0.52
107
594
130
780
1.95
8.68
3.0
2.8
0.50
0.35
e6/l
0.21
107
565
199
1374
1.82
8.53
3.2
2.5
107.91
121.62
ug/l
0.58
188
1282
70
334
2.30
8.51
2.5
1.6
—
—
—
0
0
102
566
2.05
8.48
3.0
2.8
523.98
571.99
mosm/kgh2o
1.18
87
485
364
3049
2.16
8.40
21.2
14.1
14.63
14.58
%
0.06
358
3001
98
540
2.05
8.29
4.8
3.0
216.05
576.60
ng/l
1.12
68
393
185
1260
1.81
8.22
5.7
5.8
1.21
1.21
mmol/l
0.08
176
1154
130
793
1.91
8.20
4.0
2.5
—
—
—
0
0
199
1386
1.80
8.20
3.1
2.4
—
—
—
0
0
131
805
1.90
8.06
4.0
3.3
—
—
—
0
0
77
392
2.17
7.99
1.5
1.4
1130.67
429.88
titre
0.88
15
83
392
3403
2.48
7.98
20.7
12.8
139.63
139.69
mmol/l
0.20
384
3290
49
205
2.57
7.92
1.4
1.4
—
—
—
0
0
392
3417
2.43
7.66
21.0
12.9
3.94
3.96
mmol/l
0.55
384
3296
124
762
1.88
7.56
2.9
2.8
—
—
—
0
0
126
779
1.87
7.54
3.3
2.4
6683.06
5413.14
umol/l
0.10
113
702
284
2235
1.77
7.36
4.1
3.3
—
—
—
0
0
72
376
2.10
6.96
4.8
5.7
1.02
1.03
mmol/l
0.13
65
354
53
245
2.32
6.90
2.6
4.2
1.05
0.92
%
0.13
22
88
102
608
1.88
6.76
1.6
1.4
18.50
20.59
nmol/l
0.81
89
523
72
381
2.07
6.72
2.3
2.3
158.05
116.31
ug/g
0.36
59
301
202
1472
1.69
6.69
10.2
8.3
0.00
0.00
e9/l
0.57
177
1223
53
254
2.24
6.35
2.8
3.3
—
—
—
0
0
355
3043
1.89
6.30
6.3
5.0
39.41
39.31
mmol/mol
0.07
334
2846
43
190
2.40
6.20
1.4
2.7
67.14
66.64
g/l
0.16
36
178
128
838
1.75
6.17
3.3
3.6
7.39
7.40
ph
0.25
20
154
33
130
2.66
6.02
3.2
3.4
—
—
—
0
0
141
956
1.70
5.96
2.7
3.3
2.35
2.36
mmol/l
0.29
122
860
71
393
1.96
5.82
2.4
2.3
2.40
2.37
g/l
0.16
65
365
293
2406
1.66
5.73
3.7
2.8
51.45
47.40
u/l
0.28
269
2267
408
3708
2.51
5.72
12.1
8.7
28.53
28.70
u/l
0.07
398
3570
114
737
1.74
5.69
5.3
4.0
—
—
—
0
0
73
412
1.93
5.65
2.6
2.0
—
—
—
0
0
39
173
2.38
5.58
1.2
1.2
—
—
—
0
0
48
233
2.19
5.57
2.5
4.3
0.24
0.13
%
0.31
17
76
50
248
2.15
5.51
2.7
3.3
2.26
1.62
mmol/l
0.59
42
201
426
3973
3.87
5.39
26.7
16.5
39.85
41.04
%
2.15
390
3756
426
3974
3.86
5.37
26.9
16.4
254.01
248.31
e9/l
1.06
419
3867
46
223
2.19
5.36
2.4
4.0
1.05
0.58
%
0.63
19
73
66
367
1.94
5.33
2.5
2.3
22.58
23.97
%
0.32
52
326
426
3978
3.82
5.27
26.8
16.4
4.58
4.61
e12/l
0.50
420
3860
426
3980
3.79
5.22
26.9
16.4
6.79
6.62
e9/l
1.01
420
3858
11
15
7.49
5.17
1.0
1.0
—
—
—
0
0
55
292
2.01
5.07
3.1
3.1
1.87
1.73
%
0.51
47
273
22
77
2.96
5.00
2.9
3.9
—
—
—
0
0
36
164
2.30
4.87
6.5
5.3
—
—
—
0
0
39
184
2.23
4.86
1.1
1.2
—
56.55
—
0
12
36
165
2.29
4.80
3.4
2.3
—
—
—
0
0
19
63
3.11
4.73
1.2
1.1
0.28
3.98
u/ml
1.17
13
31
368
3277
1.78
4.64
5.1
3.8
5.95
5.90
mmol/l
0.30
348
2997
369
3293
1.77
4.56
4.1
3.5
1.39
1.31
mmol/l
1.11
347
3068
36
169
2.23
4.55
3.4
3.3
4.44
4.58
pmol/l
0.32
29
148
13
27
4.93
4.53
1.5
1.6
—
—
nmol/l
—
0
0
125
874
1.60
4.51
3.3
2.8
—
—
—
0
0
134
960
1.57
4.34
3.2
3.4
7.59
8.46
mmol/l
1.16
120
825
43
222
2.04
4.28
2.5
4.3
0.15
0.16
%
0.02
13
61
15
46
3.34
4.22
1.1
1.1
3.38
1.58
u/ml
—
9
24
34
161
2.21
4.22
1.6
2.2
—
—
—
0
0
13
30
4.43
4.16
1.6
1.6
—
0.58
—
0
5
378
3421
1.78
4.13
4.7
3.8
4.71
4.70
mmol/l
0.09
360
3205
125
892
1.56
4.08
4.0
3.9
9.95
10.19
mg/mmol
0.02
76
585
14
42
3.41
4.07
1.1
1.0
31.28
2.64
u/ml
—
8
17
118
832
1.57
4.06
3.3
3.3
676.88
221.79
mg/l
0.34
70
556
131
949
1.54
3.99
2.7
2.1
—
—
—
0
0
110
768
1.58
3.94
3.5
3.6
92.49
91.42
%
0.16
103
762
14
38
3.77
3.83
1.6
1.4
—
—
—
0
0
34
168
2.11
3.81
2.4
2.6
130.97
130.82
g/l
0.01
34
163
60
363
1.76
3.71
1.2
1.2
—
—
—
0
0
95
650
1.59
3.69
1.5
1.4
2.04
2.30
g/l
1.54
63
416
16
56
2.93
3.66
1.1
1.1
1.68
2.76
u/ml
0.30
11
32
30
144
2.16
3.62
9.4
10.7
—
—
—
0
0
374
3406
1.68
3.59
4.6
3.8
1.38
1.43
mmol/l
1.50
355
3181
27
125
2.24
3.56
3.3
3.0
—
—
—
0
0
53
314
1.78
3.52
6.4
8.6
1.65
0.89
mmol/l
1.04
41
263
58
355
1.73
3.45
1.4
1.5
—
—
—
0
0
379
3472
1.69
3.45
5.2
4.2
2.83
2.83
mmol/l
0.02
356
3235
21
90
2.40
3.30
2.6
3.7
—
—
—
0
0
13
39
3.40
3.25
1.8
1.2
—
—
—
0
0
68
443
1.63
3.21
2.8
2.7
2.14
2.42
e6/l
0.10
40
235
100
713
1.52
3.21
1.4
1.2
0.72
1.62
u/ml
0.85
34
196
15
55
2.79
3.18
1.0
1.3
—
—
—
0
0
35
188
1.94
3.16
1.2
1.3
320.55
140.59
iu/ml
0.93
13
76
89
627
1.53
3.01
4.4
3.0
—
—
—
0
0
135
1038
1.43
2.95
4.4
3.9
1.43
2.22
ug/l
1.59
127
940
108
796
1.47
2.94
8.9
6.8
—
—
—
0
0
57
367
1.64
2.83
1.8
2.5
8.94
9.47
umol/l
0.05
48
318
10
28
3.63
2.80
1.8
1.7
—
—
—
0
0
43
259
1.73
2.73
6.5
4.4
—
—
—
0
0
26
134
2.00
2.66
2.0
2.6
9757.48
2827.17
u/l
0.33
13
59
11
35
3.20
2.66
1.2
2.1
105.91
105.14
mmol/l
0.26
11
35
11
35
3.20
2.66
1.2
2.1
4.23
4.04
mmol/l
0.63
11
35
11
35
3.20
2.66
1.2
2.1
—
—
—
0
0
15
61
2.51
2.64
1.5
3.0
9.30
8.13
kpa
1.41
15
61
7
15
4.72
2.60
2.0
1.0
24.46
18.13
umol/l
—
7
15
7
15
4.72
2.60
1.3
1.5
126.00
144.80
nmol/l
—
7
15
36
209
1.79
2.59
2.7
2.8
69.78
69.46
e9/l
0.02
26
161
58
385
1.58
2.55
1.4
1.4
—
—
—
0
0
100
747
1.44
2.52
4.4
3.3
0.00
0.01
estimate
0.69
32
281
7
16
4.43
2.48
1.0
1.1
—
—
—
0
0
7
16
4.43
2.48
1.1
1.3
—
—
—
0
0
55
364
1.58
2.45
4.0
7.8
104.76
104.55
mmol/l
0.14
55
364
40
244
1.70
2.44
3.5
8.6
—
—
—
0
0
14
58
2.46
2.39
1.1
1.1
6.39
11.02
u/ml
—
9
32
14
58
2.46
2.39
1.1
1.1
0.42
3.45
u/ml
—
9
28
39
238
1.70
2.38
3.1
2.6
9.22
10.60
g/l
1.44
33
224
11
39
2.87
2.36
2.5
2.6
—
—
—
0
0
10
34
2.99
2.29
2.9
2.1
—
—
—
0
0
25
136
1.89
2.23
2.8
4.4
—
—
—
0
0
5
9
5.60
2.22
1.6
1.4
1.99
1.73
umol/l
—
5
9
108
838
1.38
2.18
1.9
1.6
1.57
1.45
mmol/l
0.44
95
714
29
477
0.58
2.16
1.3
1.3
—
—
—
0
0
6
14
4.33
2.15
1.3
1.3
—
—
—
0
0
13
55
2.41
2.14
1.8
2.1
—
—
—
0
0
28
161
1.79
2.11
2.4
2.9
—
—
—
0
0
50
337
1.55
2.08
1.4
1.3
—
—
—
0
0
5
10
5.04
2.07
2.6
1.3
27.00
26.80
umol/l
—
5
10
5
10
5.04
2.07
2.8
1.9
39.60
67.56
ug/l
—
5
10
65
466
1.46
2.03
1.6
1.6
—
—
—
0
0
104
814
1.36
1.98
1.8
1.9
—
—
—
0
0
7
21
3.37
1.97
1.1
1.1
—
—
—
0
0
12
51
2.39
1.96
1.3
1.1
—
—
—
0
0
8
28
2.89
1.87
1.0
1.2
—
—
—
0
0
29
176
1.69
1.84
1.2
1.2
—
—
—
0
0
31
193
1.65
1.80
2.5
2.9
—
—
—
0
0
11
47
2.38
1.79
1.3
1.2
17.13
12.33
u/l
0.28
11
41
11
47
2.38
1.79
1.5
3.0
—
—
—
0
0
11
47
2.38
1.79
1.2
1.9
—
—
—
0
0
23
132
1.78
1.77
1.4
2.0
0.66
0.67
%
0.11
23
132
20
110
1.86
1.76
1.6
1.6
—
—
—
0
0
7
24
2.95
1.73
2.3
1.3
66.57
82.17
umol/l
—
7
24
20
111
1.84
1.71
1.2
1.2
—
—
—
0
0
67
500
1.40
1.70
2.9
3.0
2.44
2.44
mmol/l
0.12
55
447
21
120
1.79
1.65
1.1
1.4
195.11
280.30
miu/ml
—
9
57
13
63
2.10
1.61
1.8
1.3
291.38
307.79
ug/g
—
8
32
8
32
2.53
1.60
1.7
1.2
—
—
—
0
0
80
624
1.35
1.56
1.6
1.7
—
—
—
0
0
14
71
2.00
1.55
1.6
3.0
24.91
25.55
mmol/l
0.24
14
71
18
100
1.83
1.55
3.1
2.8
—
—
—
0
0
32
210
1.57
1.53
2.5
2.7
—
—
—
0
0
6
21
2.88
1.51
1.5
1.6
—
—
—
0
0
36
244
1.52
1.50
1.1
1.2
—
—
—
0
0
32
212
1.55
1.48
2.5
2.7
—
—
—
0
0
20
117
1.74
1.47
3.2
4.0
0.46
0.21
g/l
—
10
54
7
28
2.52
1.45
1.0
1.9
—
—
—
0
0
11
52
2.14
1.45
1.8
1.8
4.52
4.79
mmol/24h
0.09
11
45
32
213
1.54
1.45
2.7
2.7
—
—
—
0
0
43
306
1.45
1.43
1.4
1.6
—
—
—
0
0
31
208
1.53
1.37
2.6
2.6
—
—
—
0
0
11
54
2.06
1.34
2.7
2.7
4.02
3.90
e9/l
0.07
11
54
6
24
2.52
1.31
1.0
1.2
—
—
—
0
0
11
55
2.03
1.28
3.9
2.9
55.73
55.53
%
0.02
11
55
11
55
2.03
1.28
5.6
2.8
8.86
8.62
kpa
0.20
11
55
16
92
1.77
1.26
3.2
4.1
—
—
—
0
0
11
56
1.99
1.23
5.6
2.8
5.27
4.98
kpa
0.81
11
56
10
49
2.07
1.23
1.6
2.7
16.44
16.67
%
—
5
30
5
19
2.65
1.22
2.8
2.8
38460.00
38000.00
ug/l
—
5
19
144
1251
1.23
1.19
1.9
2.0
—
—
—
0
0
0
33
0.00
1.16
0.0
1.2
—
—
—
0
0
5
20
2.52
1.15
2.0
1.8
2107.80
1905.55
ml
—
5
20
5
20
2.52
1.15
1.4
1.2
—
—
—
0
0
28
192
1.49
1.14
3.3
3.1
—
—
—
0
0
7
31
2.28
1.11
1.6
1.4
—
—
—
0
0
5
21
2.40
1.09
1.2
1.0
—
—
—
0
0
27
186
1.48
1.09
1.0
1.1
—
—
—
0
0
11
59
1.89
1.08
4.1
3.0
—
—
—
0
0
14
82
1.73
1.06
1.1
1.1
—
—
—
0
0
14
82
1.73
1.06
2.4
3.0
9.27
12.83
mg/l
1.31
14
76
7
34
2.08
1.03
1.0
1.1
—
—
—
0
0
7
35
2.02
1.00
3.1
3.0
—
—
—
0
0
5
23
2.19
0.98
1.2
1.0
—
—
—
0
0
7
37
1.91
0.94
2.1
1.9
—
—
—
0
0
6
27
2.24
0.94
5.2
2.3
—
—
—
0
0
37
280
1.35
0.92
2.4
5.3
4.47
22.90
ug/l
0.64
29
228
6
28
2.16
0.92
1.0
1.3
—
—
—
0
0
15
95
1.60
0.88
1.1
1.1
—
—
—
0
0
13
80
1.64
0.85
1.3
1.3
—
—
—
0
0
8
47
1.71
0.81
22.0
22.5
941.13
1512.87
nmol/l
—
8
47
10
59
1.71
0.76
1.1
1.1
—
—
—
0
0
5
24
2.10
0.74
1.0
1.0
—
0.31
—
0
8
7
40
1.76
0.71
2.4
1.7
—
—
—
0
0
5
26
1.93
0.71
1.0
1.7
1.21
1.07
g/l
—
5
26
10
61
1.65
0.69
2.0
2.2
—
—
—
0
0
9
59
1.54
0.68
1.4
3.0
—
—
—
0
0
10
62
1.63
0.65
1.3
1.1
—
12.23
—
0
7
15
104
1.46
0.63
3.3
5.0
—
—
—
0
0
32
254
1.28
0.61
3.9
3.4
—
—
—
0
0
10
65
1.55
0.56
1.2
1.1
—
—
—
0
0
13
91
1.44
0.53
6.6
6.9
—
—
—
0
0
35
288
1.23
0.52
1.9
2.0
29.54
196.75
u/l
0.52
28
252
43
362
1.21
0.52
1.7
1.8
—
—
—
0
0
50
428
1.19
0.51
1.7
1.7
—
—
—
0
0
40
335
1.21
0.51
2.7
2.2
14.09
14.24
nmol/l
0.04
35
317
14
190
0.73
0.50
1.3
1.5
—
—
—
0
0
50
429
1.19
0.50
1.6
1.4
—
—
—
0
0
7
47
1.50
0.47
1.1
2.1
—
—
—
0
0
7
48
1.47
0.47
1.6
2.5
27.29
18.74
u/ml
—
7
48
45
386
1.18
0.46
1.2
1.2
—
—
—
0
0
8
56
1.44
0.42
1.6
1.2
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
14
106
1.33
0.39
1.9
1.7
—
—
—
0
0
5
35
1.43
0.39
1.2
1.3
—
—
—
0
0
10
135
0.73
0.37
2.0
2.4
208.50
58.25
u/ml
—
10
128
5
79
0.63
0.36
1.2
1.4
—
—
—
0
0
6
45
1.34
0.34
1.0
1.1
—
—
—
0
0
69
636
1.10
0.27
3.1
2.5
0.46
0.76
ug/l
4.64
42
365
8
65
1.24
0.27
1.0
1.2
—
—
—
0
0
5
38
1.32
0.23
1.2
1.8
—
—
—
0
0
25
284
0.87
0.22
1.4
1.3
—
—
—
0
0
7
93
0.75
0.22
1.4
1.6
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
91
960
0.93
0.21
1.4
1.5
—
—
—
0
0
24
268
0.89
0.18
1.2
1.4
—
—
—
0
0
11
92
1.20
0.16
1.1
1.1
—
—
—
0
0
6
56
1.07
0.08
1.2
1.1
—
—
—
0
0
6
57
1.05
0.08
1.0
2.8
—
—
—
0
0
5
62
0.80
0.08
1.0
1.1
—
—
—
0
0
5
62
0.80
0.08
1.0
1.1
—
—
—
0
0
141
1428
0.98
0.04
3.0
2.5
—
—
—
0
0
14
137
1.02
0.00
1.4
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.64
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
8.94
—
0
6
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
6
61
0.98
-0.00
1.5
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
74
0.95
-0.00
1.6
1.2
0.99
0.84
nmol/l
—
7
62
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
3.9
—
2812.63
—
0
8
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
87
0.92
-0.00
1.1
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
1.87
—
0
5
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint M13_SPINALOSTEOCHON and mortality.

Females

Parameter HR [95% CI] p-value
M13_SPINALOSTEOCHON 1.195 [1.02, 1.41] 0.031
Birth year 0.994 [0.99, 1.0] 0.182

During the follow-up period (1.1.1998 — 31.12.2019), 218 out of 1341 females with M13_SPINALOSTEOCHON died.

Males

Parameter HR [95% CI] p-value
M13_SPINALOSTEOCHON 1.222 [1.01, 1.48] 0.041
Birth year 0.986 [0.98, 1.0] 0.005

During the follow-up period (1.1.1998 — 31.12.2019), 212 out of 1938 males with M13_SPINALOSTEOCHON died.

Mortality risk

Mortality risk for people of age

years, who have M13_SPINALOSTEOCHON.

N-year risk Females Males
1 0.115% 0.219%
5 0.877% 1.405%
10 1.929% 3.729%
15 3.596% 6.762%
20 6.181% 11.273%

Relationships between endpoints

Index endpoint: M13_SPINALOSTEOCHON – Spinal osteochondrosis

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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