Other disorders of breast and lactation associated with childbirth

O15_BREAST_LACT_OTHER_DIS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

only females

293218

2. Check conditions

None

293218

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O92
  • Hospital discharge: ICD-9 676
  • Hospital discharge: ICD-8 6780[089]
  • Cause of death: ICD-10 O92
  • Cause of death: ICD-9 676
  • Cause of death: ICD-8 6780[089]

2 out of 7 registries used, show all original rules.

701

4. Check minimum number of events

None

701

5. Include endpoints

None

701

6. Filter based on genotype QC (FinnGen only)

673

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O85-O92
Name in latin
Alii morbositates mammmae et perturbationes lactationis ad partum adjunctae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3627 3627 -
Only index persons 3580 3580 -
Unadjusted period prevalence (%)
Whole population 0.10 0.10 -
Only index persons 0.13 0.13 -
Median age at first event (years)
Whole population - 31.25 -
Only index persons - 31.23 -

-FinnGen-

Key figures

All Female Male
Number of individuals 673 673 -
Unadjusted period prevalence (%) 0.24 0.24 -
Median age at first event (years) 31.68 31.68 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
701
Matched controls
7010
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O92.7
ICD-10 Finland
Other and unspecified disorders of lactation
2284.0
307.7
348
*
O92.4
ICD-10 Finland
Hypogalactia
+∞
98.3
92
*
O92.1
ICD-10 Finland
Cracked nipple associated with childbirth
492.1
89.3
87
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
4.6
89.0
351
1245
O92.6
ICD-10 Finland
Galactorrhoea
44.0
88.2
53
13
Z32.1
ICD-10 Finland
Pregnancy confirmed
4.4
82.7
365
1391
SPAT1379
SPAT
Health check-up of pregnant person
4.3
78.3
430
1896
Z37.0
ICD-10 Finland
Single live birth
4.2
76.5
321
1166
Z39.2
ICD-10 Finland
Routine postpartum follow-up
3.6
59.2
430
2155
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
3.5
57.8
419
2086
SPAT1380
SPAT
Postpartum check-up
3.5
57.3
355
1603
WX307
NOMESCO Finland
Obstetric epidural analgesia
3.5
56.9
316
1333
SPAT1197
SPAT
Extensive health check-up of expecting family
3.5
56.6
427
2170
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
3.5
55.3
441
2308
ZXE00
NOMESCO Finland
One hour or less
3.1
47.1
397
2081
ZXD10
NOMESCO Finland
Scheduled procedure
3.1
46.3
321
1504
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
2.9
41.4
350
1800
O92.2
ICD-10 Finland
Other and unspecified disorders of breast associated with childbirth
+∞
41.0
39
*
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
2.8
39.1
355
1880
O92.0
ICD-10 Finland
Retracted nipple associated with childbirth
206.1
38.2
39
*
R2110
NOMESCO Finland
Giving the first information
3.8
35.3
122
367
Z32
ICD-10 Finland
Pregnancy examination and test
7.1
34.9
54
81
W78
ICPC
Pregnancy
2.7
34.8
435
2651
O92.5
ICD-10 Finland
Suppressed lactation
342.5
33.2
33
*
O99.80
ICD-10 Finland
The fear of childbirth
3.0
30.5
163
639
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
7.4
27.8
41
58
N61
ICD-10 Finland
Inflammatory disorders of breast
3.7
23.3
79
232
67808
ICD-8 Finland
Mastitis and other disorders of lactation, Alia definitae
+∞
23.0
22
*
TMA00
NOMESCO Finland
Episiotomy
3.2
22.7
99
342
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
5.3
21.9
45
89
SPAT1315
SPAT
Periodic health check-up of children and adolescents
3.1
21.8
102
367
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
2.3
21.4
230
1240
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
2.4
20.9
178
867
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.3
20.8
204
1056
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.1
20.6
413
2824
MA3AE
NOMESCO Finland
Combined first trimester screening
2.4
20.5
172
831
Z3232
NOMESCO Finland
Midwife
2.3
19.7
201
1055
ZXD05
NOMESCO Finland
Urgent procedure
2.1
18.6
290
1787
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
2.6
18.2
119
510
W85
ICPC
Gestational diabetes
2.5
17.3
123
547
TQW30
NOMESCO Finland
Acupuncture
6.4
16.9
28
45
RF210, ,
NOMESCO Finland
4.3
16.8
45
111
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.4
16.8
133
621
S44
ICPC
Skin, Preventive immunization/medic
5.6
16.8
32
59
Z2221
NOMESCO Finland
Medical doctor
2.0
16.5
252
1528
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
2.5
16.2
117
524
MAX99
NOMESCO Finland
Assistance to normal delivery
2.0
16.0
228
1346
6764A
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Failure of lactation
+∞
15.7
15
*
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
29.3
15.3
20
7
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.5
14.6
98
423
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.0
14.1
177
992
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
15.1
13.6
22
15
WX322
NOMESCO Finland
Combined spinal-epidural analgesia in obstetrics
3.0
13.6
64
230
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.8
13.5
366
2626
WX320
NOMESCO Finland
Spinalanesthesy
2.0
13.5
174
982
O85
ICD-10 Finland
Puerperal sepsis
142.7
13.5
14
*
O86.8
ICD-10 Finland
Other specified puerperal infections
142.7
13.5
14
*
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.2
12.8
52
171
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
3.0
12.8
57
198
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.8
12.6
289
1959
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
1.9
12.3
182
1075
ZXE10
NOMESCO Finland
More than one and less than three hours
1.9
11.9
212
1326
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
1.8
11.8
225
1436
W90
ICPC
Uncompl labour/delivery livebirth
2.1
11.8
133
711
67809
ICD-8 Finland
Mastitis and other disorders of lactation, Unspecified
+∞
11.5
11
*
Z3226
NOMESCO Finland
Physiotherapist
2.1
11.5
119
617
Z39.1
ICD-10 Finland
Care and examination of lactating mother
2.7
11.3
61
236
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
3.4
11.0
39
118
O70.0
ICD-10 Finland
First degree perineal laceration during delivery
4.1
10.9
30
76
SPAT1196
SPAT
Monitoring of normal pregnancy
1.9
10.6
160
945
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
1.7
10.4
405
3132
SPAT1195
SPAT
Antenatal classes
2.3
10.2
83
390
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
2.0
10.1
117
630
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
2.9
10.0
49
180
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.7
9.9
239
1621
O71.4
ICD-10 Finland
Obstetric high vaginal laceration
4.5
9.4
23
53
Z39
ICD-10 Finland
Postpartum care and examination
3.3
9.2
35
111
P01AB01
ATC
metronidazole; oral, rectal
1.6
9.2
304
2230
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.0
9.0
104
558
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
2.0
9.0
110
604
G02CB01
ATC
bromocriptine; systemic
4.0
8.7
24
61
6768X
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Other disorders of lactation
+∞
8.3
8
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
1.9
8.3
122
710
MWA00
NOMESCO Finland
Repair of wound dehiscence in obstetric surgery
33.8
8.1
10
*
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
2.4
8.1
56
245
O70.1
ICD-10 Finland
Second degree perineal laceration during delivery
2.3
8.0
62
285
MBA30
NOMESCO Finland
Manual removal of placenta from delivered uterus
3.0
7.9
34
116
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
3.1
7.8
32
106
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
2.6
7.7
46
187
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
7.6
490
4134
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
3.2
7.5
30
98
O20.0
ICD-10 Finland
Threatened abortion
2.7
7.4
39
149
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
1.9
7.4
103
589
O92.3
ICD-10 Finland
Agalactia
+∞
7.3
7
*
O32.1
ICD-10 Finland
Maternal care for breech presentation
2.0
7.0
74
385
O47
ICD-10 Finland
False labour
3.2
6.9
27
87
O75.7
ICD-10 Finland
Vaginal delivery following previous caesarean section
7.6
6.9
15
20
O26.7
ICD-10 Finland
Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium
3.3
6.9
25
77
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
2.1
6.6
61
301
SEMI, ,
NOMESCO Finland
6.9
6.5
15
22
MBA04
NOMESCO Finland
Curettage of uterus after delivery
4.0
6.5
18
46
O86.4
ICD-10 Finland
Pyrexia of unknown origin following delivery
70.5
6.4
7
*
W84
ICPC
Pregnancy high risk
1.9
6.4
83
463
6765A
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Suppressed lactation
+∞
6.3
6
*
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
5.1
6.2
18
36
SPAT1281
SPAT
Other administrative function
2.0
6.2
68
359
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.7
6.1
134
872

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
277
748
5.47
100.78
1.7
1.4
—
—
—
0
0
277
750
5.45
100.42
1.7
1.4
—
—
—
0
0
279
770
5.36
98.66
1.7
1.5
—
—
—
0
0
293
910
4.81
88.19
1.7
1.4
—
—
—
0
0
97
163
6.75
56.83
2.6
2.4
—
—
—
0
0
294
1251
3.33
51.10
2.6
2.2
—
—
—
0
0
298
1279
3.31
51.04
3.7
2.6
0.07
0.25
e6/l
4.63
203
933
313
1411
3.20
48.90
3.6
2.7
14.38
68.38
e6/l
1.61
215
1041
291
1296
3.13
45.83
3.6
2.6
—
—
—
0
0
236
979
3.13
41.37
2.8
2.3
7.17
10.35
e6/l
1.57
180
863
98
232
4.75
39.12
2.1
2.3
—
—
—
0
0
103
273
4.25
35.49
2.0
1.6
—
—
—
0
0
174
674
3.10
33.55
2.8
2.3
2.71
4.40
e6/l
2.13
113
342
341
1884
2.58
32.90
3.9
3.1
29.53
45.34
e6/l
0.88
227
1137
177
705
3.02
32.39
2.8
2.2
0.40
1.63
e6/l
1.08
116
375
204
925
2.70
28.89
2.9
2.4
530.16
535.99
mosm/kgh2o
0.12
148
788
120
414
3.29
27.76
2.8
2.5
—
—
—
0
0
461
3172
2.32
24.31
2.9
2.5
—
—
—
0
0
409
2679
2.26
24.29
2.0
1.8
—
—
—
0
0
380
2481
2.16
21.91
1.9
1.7
—
—
—
0
0
214
1128
2.29
20.93
1.3
1.4
—
—
—
0
0
27
37
7.55
18.77
2.2
3.4
—
—
—
0
0
396
2753
2.01
17.87
2.4
1.9
—
—
—
0
0
233
1404
1.99
15.28
1.7
1.7
—
—
—
0
0
96
417
2.51
14.10
1.2
1.2
—
—
—
0
0
287
1916
1.84
13.40
1.8
1.8
—
—
—
0
0
541
4412
1.99
13.05
4.4
3.9
—
—
—
0
0
416
3150
1.79
12.40
2.2
2.1
—
—
—
0
0
216
1372
1.83
11.49
2.4
3.2
—
—
—
0
0
73
342
2.27
8.99
2.0
2.1
4.11
4.48
umol/l
0.32
55
250
173
1165
1.64
6.99
1.9
3.0
99.33
98.34
%
0.22
165
1121
439
3759
1.45
5.21
3.3
3.0
46.14
51.55
ug/l
2.03
423
3553
695
6758
4.32
4.87
14.0
13.9
38.93
39.53
%
2.81
687
6472
30
125
2.46
4.86
1.4
1.4
—
—
—
0
0
140
981
1.53
4.62
2.2
2.4
62.53
85.66
ug/g
1.38
119
736
695
6767
4.16
4.57
14.1
14.0
4.41
4.45
e12/l
2.05
687
6639
695
6765
4.19
4.56
14.1
14.1
7.10
6.88
e9/l
1.99
687
6627
32
142
2.31
4.54
3.1
2.7
—
—
—
0
0
637
5961
1.75
4.45
9.1
9.1
18.72
17.64
mg/l
0.43
507
4567
694
6760
3.67
4.23
14.1
14.1
263.57
268.18
e9/l
1.41
679
6634
196
1504
1.42
4.04
1.4
1.4
1.89
2.05
g/l
1.35
108
943
229
1823
1.38
3.77
1.3
1.3
1.78
1.34
u/ml
0.27
53
503
364
3140
1.33
3.46
2.7
3.1
0.00
0.00
estimate
0.80
68
699
362
3133
1.32
3.30
3.7
4.2
0.00
0.00
estimate
0.50
67
691
365
3164
1.32
3.29
2.9
3.1
0.00
0.00
estimate
-0.00
66
675
611
5744
1.50
3.19
5.2
5.0
1.51
1.88
mu/l
1.15
594
5485
19
79
2.44
3.16
3.7
3.3
—
—
—
0
0
95
664
1.50
3.16
1.4
1.6
272.10
290.51
mu/l
0.20
89
586
9
23
3.95
2.78
1.1
1.0
187.78
342.78
u/l
—
9
18
581
5449
1.39
2.71
7.2
8.0
139.44
139.37
mmol/l
0.42
571
5258
116
868
1.40
2.70
2.5
3.3
—
—
—
0
0
93
669
1.45
2.69
1.9
2.0
2.38
2.40
mmol/l
1.94
70
576
329
2864
1.28
2.68
3.7
3.7
6.04
6.04
mmol/l
0.01
247
2458
361
3181
1.28
2.66
5.0
7.8
4.01
4.00
e9/l
0.04
305
2801
7
15
4.70
2.60
1.1
1.0
—
—
—
0
0
7
15
4.70
2.60
1.1
1.0
—
—
—
0
0
7
15
4.70
2.60
1.1
1.0
—
—
—
0
0
29
157
1.88
2.56
4.6
7.2
—
—
—
0
0
7
16
4.41
2.48
1.0
1.2
—
—
—
0
0
579
5458
1.35
2.36
7.3
8.1
3.85
3.87
mmol/l
1.94
569
5248
410
3707
1.26
2.29
4.7
5.8
66.32
69.36
u/l
1.70
369
3472
83
604
1.42
2.27
1.2
1.3
15.93
16.73
iu/l
0.12
75
511
32
190
1.72
2.13
1.1
1.3
—
—
—
0
0
267
2315
1.25
2.12
2.3
2.2
76.91
72.35
nmol/l
1.82
237
2177
545
5118
1.29
2.11
4.6
4.3
13.92
14.19
pmol/l
2.40
523
4825
117
914
1.34
2.10
1.4
1.4
476.36
505.26
titre
0.07
22
190
136
1089
1.31
2.05
1.3
1.2
4.34
9.70
u/ml
1.17
51
459
132
1053
1.31
2.04
1.9
2.1
4467.34
3655.11
umol/l
0.10
119
958
86
643
1.38
2.03
1.2
1.2
—
—
—
0
0
142
1150
1.29
1.97
1.3
1.3
15.27
23.23
iu/ml
1.37
32
361
449
4145
1.23
1.90
2.3
2.6
23.27
27.71
u/l
3.37
436
3960
8
28
2.88
1.86
3.0
3.0
480.25
636.43
u/ml
—
8
28
72
532
1.39
1.84
1.2
1.3
—
—
—
0
0
5
12
4.19
1.82
1.0
1.2
—
—
—
0
0
20
347
0.56
1.78
1.2
1.3
—
—
—
0
0
161
1910
0.80
1.78
2.4
2.6
—
—
—
0
0
16
81
2.00
1.76
1.6
1.3
—
—
—
0
0
0
46
0.00
1.71
0.0
1.1
—
—
—
0
0
48
335
1.46
1.68
2.4
3.3
—
—
—
0
0
479
4477
1.22
1.68
3.5
3.7
35.76
36.62
mmol/mol
1.61
461
4240
83
640
1.34
1.64
1.5
1.8
—
—
—
0
0
439
4073
1.21
1.64
3.4
3.4
7.68
8.45
mm/h
1.53
423
3810
17
92
1.87
1.57
1.5
1.3
—
—
—
0
0
12
232
0.51
1.55
3.4
7.8
6.21
6.68
mmol/l
0.13
12
226
69
523
1.35
1.54
1.8
2.2
4.76
4.97
umol/l
0.15
58
417
51
370
1.41
1.48
1.2
1.2
9.96
10.13
u/l
0.04
46
303
657
6400
1.42
1.48
8.8
8.8
—
—
—
0
0
35
236
1.51
1.47
4.8
5.9
1.06
1.24
mmol/l
1.06
35
230
7
28
2.51
1.45
3.7
1.9
—
—
—
0
0
55
406
1.38
1.45
1.1
1.2
—
—
—
0
0
36
246
1.49
1.43
1.5
1.7
—
—
—
0
0
7
29
2.43
1.39
1.3
1.1
—
—
—
0
0
5
17
2.95
1.36
1.4
1.3
123.80
161.69
mmol/24h
—
5
17
310
2820
1.18
1.36
3.9
5.3
0.04
0.04
e9/l
0.36
257
2510
628
6088
1.30
1.35
6.9
7.4
22.54
22.43
u/l
0.06
623
5882
65
500
1.33
1.34
1.3
1.3
326.95
236.93
miu/ml
1.01
33
262
9
42
2.16
1.34
3.2
1.6
—
—
—
0
0
154
1317
1.22
1.34
3.2
6.0
—
—
—
0
0
323
2952
1.17
1.33
3.9
5.2
1.97
2.00
e9/l
0.38
301
2697
74
582
1.30
1.31
1.7
1.9
402.28
380.97
nmol/l
0.53
69
538
22
138
1.61
1.27
1.1
1.4
2.33
4.37
u/ml
—
6
59
70
882
0.77
1.27
4.1
4.2
19.47
13.67
mg/mmol
0.27
43
582
6
25
2.41
1.24
1.2
1.2
0.02
0.04
u/ml
—
6
25
80
641
1.28
1.24
2.3
2.4
81.50
194.06
ng/l
0.56
22
288
97
796
1.25
1.24
1.5
1.4
—
—
—
0
0
319
2925
1.17
1.23
3.9
5.6
0.18
0.17
e9/l
0.43
292
2651
5
19
2.64
1.22
2.0
1.7
—
—
—
0
0
25
166
1.52
1.16
1.2
1.1
—
—
—
0
0
25
166
1.52
1.16
1.2
1.1
—
—
—
0
0
166
1449
1.19
1.16
1.9
2.4
54.01
56.13
u/l
0.47
152
1341
307
2817
1.16
1.16
3.9
5.3
0.49
0.52
e9/l
1.50
259
2512
69
548
1.29
1.15
1.4
1.3
—
—
—
0
0
29
200
1.47
1.14
1.0
1.1
1.28
0.91
u/ml
0.21
17
82
279
2545
1.16
1.13
3.9
5.2
0.65
0.65
%
0.05
251
2376
7
30
2.35
1.12
1.0
1.0
—
—
—
0
0
7
32
2.20
1.08
1.6
1.3
—
—
—
0
0
76
617
1.26
1.08
1.5
1.6
—
—
—
0
0
149
1700
0.84
1.07
2.8
3.2
0.00
0.00
estimate
1.08
66
683
29
203
1.45
1.07
1.1
1.1
1.14
1.48
u/ml
0.18
19
99
60
474
1.29
1.06
2.3
2.0
30.45
33.70
u/l
0.40
53
391
114
977
1.20
0.98
1.5
1.4
22.37
21.41
nmol/l
0.29
101
867
288
2655
1.14
0.98
3.9
5.1
2.72
2.59
%
0.37
263
2493
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
30
216
1.41
0.97
1.0
1.1
7.79
6.09
u/ml
0.16
20
115
10
54
1.86
0.97
1.3
1.3
1.82
2.88
g/l
—
5
40
10
54
1.86
0.97
1.3
1.3
0.25
0.37
g/l
—
5
40
10
54
1.86
0.97
1.3
1.3
6.54
6.16
g/l
—
5
40
10
54
1.86
0.97
1.3
1.3
—
—
—
0
0
27
191
1.43
0.96
1.0
1.2
—
—
—
0
0
78
646
1.23
0.95
1.7
2.1
2.49
2.51
g/l
0.18
72
592
52
651
0.78
0.93
1.6
1.5
1151.39
1147.45
nmol/l
0.01
43
504
300
2782
1.14
0.93
3.8
5.0
57.25
56.58
%
0.53
274
2628
71
851
0.82
0.88
3.5
3.6
93.03
305.76
mg/l
0.87
47
585
8
43
1.87
0.87
1.0
1.5
—
—
—
0
0
6
31
1.94
0.84
7.0
3.3
—
—
—
0
0
144
1278
1.16
0.84
1.5
1.5
—
—
—
0
0
192
1740
1.14
0.83
1.7
1.7
102.54
97.78
pmol/l
0.54
102
998
33
249
1.34
0.83
3.3
3.7
58.68
69.41
ng/l
1.05
28
226
19
130
1.47
0.81
1.4
1.3
283.33
342.67
ug/g
—
6
63
301
2812
1.12
0.80
3.9
5.1
29.72
29.97
%
0.17
277
2661
32
242
1.34
0.80
1.1
1.1
0.97
3.30
u/ml
2.33
24
125
163
1466
1.15
0.79
2.3
2.7
2.34
2.34
mmol/l
0.08
155
1325
285
2660
1.12
0.77
4.4
5.5
—
—
—
0
0
28
209
1.35
0.77
6.3
7.5
—
—
—
0
0
28
209
1.35
0.77
1.7
1.3
—
—
—
0
0
11
173
0.63
0.76
1.2
1.2
—
—
—
0
0
11
173
0.63
0.76
1.5
1.6
6.82
6.66
mmol/l
0.09
11
158
286
2674
1.12
0.74
4.1
5.4
7.42
7.67
%
0.83
261
2520
9
56
1.61
0.72
1.2
1.1
—
—
—
0
0
9
56
1.61
0.72
1.7
1.8
5.10
5.38
mmol/l
—
9
46
523
5062
1.13
0.72
2.6
2.7
1.09
1.11
mmol/l
0.27
504
4816
52
428
1.23
0.70
1.2
1.2
—
—
—
0
0
326
3081
1.11
0.68
2.3
2.5
—
—
—
0
0
68
578
1.20
0.68
1.8
2.3
26.70
23.77
%
1.15
63
494
252
2351
1.11
0.67
3.6
4.4
9.61
9.17
umol/l
0.60
237
2184
25
188
1.34
0.67
1.5
1.3
27.00
36.78
nmol/l
1.51
25
172
16
111
1.45
0.66
1.7
2.4
—
—
—
0
0
107
1202
0.87
0.65
2.9
3.4
7.48
7.67
mmol/l
0.14
93
1058
530
5147
1.12
0.64
3.0
3.0
5.38
5.47
mmol/l
1.32
512
4824
87
990
0.86
0.63
2.6
2.4
—
—
—
0
0
31
244
1.28
0.62
1.2
2.2
21.35
20.43
s
0.59
23
202
66
566
1.18
0.61
1.3
1.3
—
—
—
0
0
9
137
0.65
0.61
1.6
1.9
13.22
13.03
%
—
9
137
8
51
1.58
0.60
1.0
1.0
—
—
—
0
0
172
1581
1.12
0.60
6.5
5.9
1.07
1.04
inr
0.39
73
564
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
0
21
0.00
0.60
0.0
2.3
—
13.71
—
0
21
0
22
0.00
0.59
0.0
2.3
—
230.57
—
0
5
0
22
0.00
0.59
0.0
2.2
—
9.48
—
0
17
28
219
1.29
0.59
2.5
2.0
3.01
4.46
iu/l
—
9
89
35
282
1.25
0.59
1.6
1.6
—
—
—
0
0
10
64
1.57
0.59
1.0
1.0
—
—
—
0
0
6
37
1.63
0.55
1.2
1.3
—
—
—
0
0
18
133
1.36
0.55
7.1
9.1
95.21
94.54
%
0.45
18
133
18
134
1.35
0.53
7.1
9.0
1.43
1.34
%
0.17
18
134
13
91
1.44
0.53
3.4
4.9
—
—
—
0
0
93
1037
0.88
0.52
2.3
2.3
11391.35
6760.02
u/l
0.49
44
464
121
1100
1.12
0.52
1.9
1.9
101.06
180.50
u/l
0.77
115
1052
6
99
0.60
0.52
1.3
2.2
7.43
7.42
ph
—
6
88
188
1752
1.10
0.51
2.1
2.2
—
—
—
0
0
52
446
1.18
0.50
2.4
2.2
20.73
22.56
au/ml
—
8
39
6
41
1.47
0.50
1.2
1.6
—
—
—
0
0
18
136
1.33
0.49
7.1
9.0
0.77
0.69
%
0.37
18
136
22
172
1.29
0.48
1.9
2.4
5.02
5.11
kpa
0.27
22
163
548
5360
1.10
0.48
3.0
3.0
4.69
4.71
mmol/l
0.27
537
5121
7
47
1.49
0.47
1.0
1.1
—
—
—
0
0
10
68
1.48
0.47
1.1
1.0
—
—
—
0
0
87
965
0.89
0.46
1.1
1.2
—
—
—
0
0
5
83
0.60
0.46
1.0
2.6
—
—
—
0
0
7
50
1.40
0.45
1.3
1.3
—
—
—
0
0
14
186
0.75
0.45
2.1
2.2
—
—
—
0
0
545
5337
1.10
0.44
2.9
3.0
1.52
1.55
mmol/l
0.96
532
5095
20
157
1.28
0.44
1.3
1.2
—
—
—
0
0
71
635
1.13
0.41
1.5
1.5
—
—
—
0
0
5
33
1.52
0.41
1.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
81.78
—
0
9
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
4.1
—
—
—
0
0
0
16
0.00
0.41
0.0
2.8
—
—
—
0
0
20
249
0.80
0.41
1.1
1.1
2.00
4.22
u/ml
—
5
33
5
34
1.47
0.40
2.4
2.3
—
—
—
0
0
5
34
1.47
0.40
1.2
1.1
191.60
145.95
iu/ml
—
5
34
0
18
0.00
0.40
0.0
1.5
—
—
—
0
0
0
18
0.00
0.40
0.0
4.2
—
—
—
0
0
8
61
1.32
0.39
1.0
2.0
—
—
—
0
0
5
35
1.43
0.39
2.0
1.6
71.20
55.73
%
—
5
30
9
67
1.35
0.38
1.0
1.0
195.11
189.47
mg/l
—
9
57
16
125
1.29
0.37
1.1
1.1
—
—
—
0
0
5
37
1.35
0.37
1.0
1.0
—
—
—
0
0
39
449
0.86
0.37
1.4
2.1
26.89
37.57
u/ml
0.62
39
429
11
81
1.36
0.36
2.8
1.6
6.11
4.89
mmol/24h
0.50
11
70
19
153
1.25
0.35
1.0
1.0
0.02
0.11
u/ml
—
9
41
6
42
1.43
0.35
1.8
1.2
—
94.20
—
0
5
6
43
1.40
0.35
1.2
1.3
93.40
92.49
%
—
6
43
12
156
0.77
0.35
3.4
6.1
23.66
24.12
mmol/l
0.22
12
148
6
44
1.37
0.34
3.5
1.3
24.63
42.00
mu/l
—
6
37
17
136
1.26
0.34
2.8
1.9
—
—
—
0
0
41
466
0.87
0.33
2.0
1.8
—
—
—
0
0
44
388
1.14
0.33
2.9
2.2
10.46
10.42
g/l
0.03
39
358
6
86
0.70
0.33
1.3
1.6
—
—
—
0
0
252
2421
1.06
0.32
1.8
1.9
—
—
—
0
0
23
193
1.20
0.31
1.1
1.1
—
—
—
0
0
143
1350
1.07
0.30
1.6
1.8
1.24
0.84
mg/l
0.36
110
985
62
564
1.11
0.30
1.4
1.3
—
—
—
0
0
139
1470
0.93
0.29
2.0
2.0
2.44
2.60
mg/l
0.49
125
1262
7
56
1.25
0.29
1.0
1.1
—
—
nmol/l
—
0
0
65
594
1.10
0.29
2.1
2.7
0.92
0.83
mmol/l
1.70
60
567
548
5399
1.07
0.29
3.1
3.2
2.81
2.80
mmol/l
0.14
533
5135
8
63
1.27
0.28
1.0
1.3
—
—
—
0
0
8
65
1.23
0.27
1.5
1.2
—
—
—
0
0
8
67
1.20
0.26
1.8
1.3
—
—
—
0
0
11
86
1.28
0.26
1.3
1.5
0.45
0.47
g/l
—
6
68
5
72
0.69
0.26
1.0
1.1
—
—
—
0
0
121
1279
0.93
0.26
1.7
1.6
—
—
—
0
0
21
179
1.18
0.25
1.1
1.1
1.21
4.05
u/ml
1.73
12
84
10
78
1.29
0.24
2.0
1.5
—
—
—
0
0
18
152
1.19
0.24
1.2
1.4
365.78
382.48
mg/l
0.16
18
145
26
296
0.87
0.23
1.4
1.3
—
—
—
0
0
192
1992
0.95
0.23
4.5
4.8
1.22
1.22
mmol/l
0.17
160
1674
5
41
1.22
0.22
1.4
2.1
56.20
61.83
%
—
5
41
28
248
1.13
0.22
1.1
1.1
—
—
—
0
0
16
135
1.19
0.21
1.1
1.3
3.99
3.48
mmol/l
0.93
16
127
5
42
1.19
0.21
1.6
1.3
53.20
67.24
umol/l
—
5
42
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
2925.67
—
0
6
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
23118.00
—
0
5
0
11
0.00
0.21
0.0
1.1
—
40.83
—
0
6
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
0
12
0.00
0.21
0.0
3.0
—
—
—
0
0
57
528
1.09
0.21
3.3
3.3
4.63
4.61
pmol/l
0.05
51
471
0
13
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
19
164
1.16
0.20
1.1
1.1
1.36
4.85
u/ml
—
9
66
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
13
108
1.21
0.20
1.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.8
2.1
1.33
0.99
%
—
6
44
6
49
1.23
0.20
1.3
1.1
—
—
—
0
0
15
127
1.19
0.19
1.2
1.3
—
—
—
0
0
12
100
1.20
0.18
1.0
1.1
—
—
—
0
0
7
59
1.19
0.18
1.4
1.5
—
—
—
0
0
7
59
1.19
0.18
1.3
2.1
12.77
12.85
u/ml
—
7
59
183
1773
1.04
0.17
3.4
4.0
37.71
37.07
g/l
0.93
174
1667
7
61
1.15
0.17
1.1
2.0
—
—
—
0
0
5
66
0.76
0.17
1.2
1.3
—
—
—
0
0
37
340
1.09
0.17
5.2
5.8
104.86
104.98
mmol/l
0.05
37
340
5
70
0.71
0.16
1.4
1.1
—
—
—
0
0
8
68
1.18
0.16
1.6
4.1
3.53
3.77
mmol/l
—
8
68
8
68
1.18
0.16
1.1
2.5
—
—
—
0
0
16
183
0.87
0.16
1.9
2.5
44.73
96.12
ng/l
1.99
11
155
35
380
0.92
0.16
2.9
4.3
0.00
0.05
%
—
5
75
26
235
1.11
0.16
5.9
7.3
97.43
96.22
%
1.41
26
229
9
83
1.09
0.14
1.7
3.9
1.21
1.38
mmol/l
—
9
83
64
608
1.06
0.13
1.3
1.3
—
—
—
0
0
172
1764
0.97
0.13
4.1
4.2
1.22
1.22
mmol/l
0.12
162
1623
117
1209
0.96
0.13
1.5
1.5
1.14
1.30
mmol/l
1.84
105
1070
34
364
0.93
0.12
2.6
2.8
—
—
—
0
0
73
761
0.95
0.11
1.3
1.2
115.39
145.74
iu/ml
0.30
23
302
190
1859
1.03
0.11
2.2
2.8
24.18
26.40
u/l
1.01
185
1770
126
1296
0.97
0.11
2.4
2.3
14.96
19.70
ng/l
0.37
49
440
24
260
0.92
0.11
2.4
2.3
—
—
—
0
0
24
221
1.09
0.11
1.5
1.6
—
—
—
0
0
13
146
0.89
0.10
1.2
1.3
335.29
230.10
u/ml
—
7
98
16
144
1.11
0.10
1.1
1.3
—
—
—
0
0
258
2541
1.02
0.10
2.3
2.9
6.22
5.95
ph
1.08
39
246
136
1328
1.03
0.09
2.4
3.4
1.01
1.02
kg/l
0.70
22
221
124
1209
1.03
0.09
3.0
3.3
7.40
7.40
ph
0.25
29
233
21
227
0.92
0.09
6.9
7.4
120.52
121.64
g/l
0.09
21
222
24
224
1.07
0.08
2.7
2.1
73.79
74.58
e9/l
0.03
19
156
16
146
1.10
0.08
2.2
4.7
—
—
—
0
0
41
429
0.95
0.08
1.5
2.1
4.10
5.55
e9/l
0.98
35
392
89
914
0.97
0.07
1.5
1.5
152564526.50
64524519.60
pmol/l
0.24
78
809
31
327
0.95
0.07
1.3
1.2
—
—
—
0
0
10
112
0.89
0.07
1.7
2.6
—
—
—
0
0
8
78
1.03
0.07
1.0
1.4
—
66.88
—
0
5
7
85
0.82
0.07
2.0
3.2
0.56
0.97
nmol/l
—
7
72
16
173
0.92
0.06
1.4
1.6
—
3.34
—
0
5
13
142
0.91
0.06
1.3
1.4
—
107.65
—
0
31
9
100
0.90
0.06
2.8
3.4
56.33
57.20
%
—
9
100
9
105
0.86
0.06
1.3
2.5
24.39
24.40
mmol/l
—
9
98
10
111
0.90
0.06
1.1
1.2
—
—
—
0
0
13
119
1.09
0.06
3.1
2.6
0.68
0.68
%
0.01
13
119
63
647
0.97
0.05
1.1
1.1
—
—
—
0
0
29
277
1.05
0.05
5.5
6.7
4.71
4.97
kpa
1.10
29
264
29
277
1.05
0.05
5.5
6.7
13.80
13.58
kpa
0.07
29
265
40
414
0.96
0.05
2.6
4.2
1.22
0.74
%
—
9
107
67
685
0.98
0.04
1.2
1.2
—
—
—
0
0
55
564
0.97
0.04
1.7
1.9
—
—
—
0
0
55
562
0.98
0.03
1.7
1.9
—
—
—
0
0
39
380
1.03
0.03
2.7
4.0
0.11
0.58
%
—
9
89
13
122
1.07
0.02
3.1
2.7
0.95
1.34
%
0.96
13
122
14
132
1.06
0.02
5.9
9.0
—
—
—
0
0
43
421
1.02
0.02
2.0
2.4
—
—
—
0
0
13
137
0.95
0.01
1.1
1.0
0.98
2.50
u/ml
—
5
70
226
2251
1.01
0.01
2.0
2.0
—
—
—
0
0
258
2589
0.99
0.01
5.4
7.1
0.00
0.00
e9/l
1.64
195
2133
52
527
0.99
0.01
1.8
1.9
—
—
—
0
0
14
146
0.96
0.00
1.4
1.4
—
—
—
0
0
40
394
1.02
0.00
2.6
4.3
0.11
0.10
%
—
9
87
56
566
0.99
0.00
1.7
1.9
—
—
—
0
0
25
245
1.02
0.00
2.9
3.5
6.01
5.81
kpa
0.54
25
239
16
163
0.98
0.00
2.1
2.7
132.81
131.80
g/l
0.09
16
158
13
128
1.02
0.00
2.3
3.2
25.64
24.93
mmol/l
0.70
13
122
63
626
1.01
0.00
2.6
2.9
—
—
—
0
0
23
232
0.99
0.00
2.6
3.9
2.20
9.29
ug/l
1.77
12
166
56
558
1.00
0.00
1.7
1.9
—
—
—
0
0
25
249
1.00
0.00
2.9
3.2
—
—
—
0
0
39
389
1.00
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
13.78
—
0
5
0
5
0.00
0.00
0.0
2.0
—
243.00
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
1.22
—
0
5
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
2.8
2.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.4
—
58.81
—
0
8
9
99
0.91
-0.00
2.7
3.1
3.43
4.28
e9/l
—
9
99
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
14.98
—
0
6
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
3.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
151.21
—
0
7
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.7
—
1.19
—
0
9
5
49
1.02
-0.00
1.0
2.5
1.36
1.52
e9/l
—
5
43
7
74
0.95
-0.00
1.6
1.8
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
14.84
—
0
7
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
9.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.2
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint O15_BREAST_LACT_OTHER_DIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_BREAST_LACT_OTHER_DIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_BREAST_LACT_OTHER_DIS – Other disorders of breast and lactation associated with childbirth

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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