Other disorders of breast and lactation associated with childbirth

O15_BREAST_LACT_OTHER_DIS

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

only females

293373

2. Check conditions

None

293373

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 O92
  • Hospital discharge: ICD-9 676
  • Hospital discharge: ICD-8 6780[089]
  • Cause of death: ICD-10 O92
  • Cause of death: ICD-9 676
  • Cause of death: ICD-8 6780[089]

2 out of 7 registries used, show all original rules.

680

4. Check minimum number of events

None

680

5. Include endpoints

None

680

6. Filter based on genotype QC (FinnGen only)

680

Control definitions (FinnGen only)

Control exclude
O15_COMPLIC_PUERP

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5
Parent code in ICD-10
O85-O92
Name in latin
Alii morbositates mammmae et perturbationes lactationis ad partum adjunctae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3627 3627 -
Only index persons 3580 3580 -
Unadjusted period prevalence (%)
Whole population 0.10 0.10 -
Only index persons 0.13 0.13 -
Median age at first event (years)
Whole population - 31.25 -
Only index persons - 31.23 -

-FinnGen-

Key figures

All Female Male
Number of individuals 680 680 -
Unadjusted period prevalence (%) 0.23 0.23 -
Median age at first event (years) 31.64 31.64 -

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
629
Matched controls
6289
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
O92.7
ICD-10 Finland
Other and unspecified disorders of lactation
5316.1
323.0
307
*
O92.1
ICD-10 Finland
Cracked nipple associated with childbirth
473.2
85.2
83
*
O92.4
ICD-10 Finland
Hypogalactia
912.6
83.5
80
*
MA2JE
NOMESCO Finland
Ultrasound screening of fetal nuchal translucency
4.8
68.7
314
1084
Z32.1
ICD-10 Finland
Pregnancy confirmed
4.7
68.1
320
1134
SPAT1379
SPAT
Health check-up of pregnant person
4.4
66.4
385
1658
Z37.0
ICD-10 Finland
Single live birth
4.5
62.4
294
1020
Z39.2
ICD-10 Finland
Routine postpartum follow-up
3.9
57.7
382
1770
MA2AE
NOMESCO Finland
Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus
3.9
56.4
390
1861
MA2HE
NOMESCO Finland
Detailed morfological ultrasound examination of fetus
3.8
54.1
379
1800
SPAT1197
SPAT
Extensive health check-up of expecting family
3.6
51.1
384
1896
WX307
NOMESCO Finland
Obstetric epidural analgesia
3.9
50.7
278
1056
SPAT1380
SPAT
Postpartum check-up
3.5
47.2
316
1395
O92.6
ICD-10 Finland
Galactorrhoea
76.6
38.4
43
6
O92.0
ICD-10 Finland
Retracted nipple associated with childbirth
201.8
37.2
38
*
O92.2
ICD-10 Finland
Other and unspecified disorders of breast associated with childbirth
377.9
36.4
36
*
W78
ICPC
Pregnancy
2.9
35.7
380
2166
Z34.0
ICD-10 Finland
Supervision of normal first pregnancy
3.0
35.5
312
1567
Z34.8
ICD-10 Finland
Supervision of other normal pregnancy
3.0
34.9
304
1512
O92.5
ICD-10 Finland
Suppressed lactation
+∞
30.5
29
*
R2110
NOMESCO Finland
Giving the first information
3.8
24.2
114
350
O99.80
ICD-10 Finland
The fear of childbirth
3.3
24.1
136
481
67808
ICD-8 Finland
Mastitis and other disorders of lactation, Alia definitae
+∞
20.9
20
*
MA3AE
NOMESCO Finland
Combined first trimester screening
2.9
20.9
142
566
Z32
ICD-10 Finland
Pregnancy examination and test
7.2
20.8
51
76
SPAT1317
SPAT
Planned health check-up monitoring, health check-up performed based on individual need
2.4
20.0
206
1046
MA5AE
NOMESCO Finland
Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation
2.9
19.8
140
573
O80.0
ICD-10 Finland
Spontaneous vertex delivery
2.2
19.3
363
2429
O47.0
ICD-10 Finland
False labour before 37 completed weeks of gestation
2.5
18.6
177
854
SPAT1315
SPAT
Periodic health check-up of children and adolescents
3.4
18.1
92
298
MAX99
NOMESCO Finland
Assistance to normal delivery
2.3
17.4
208
1121
WX321
NOMESCO Finland
Acute spinal anesthesia for delivery
3.0
16.9
104
386
6764A
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Failure of lactation
+∞
15.7
15
*
TMA00
NOMESCO Finland
Episiotomy
3.1
15.2
89
317
N61
ICD-10 Finland
Inflammatory disorders of breast
3.7
15.1
67
194
O91.2
ICD-10 Finland
Nonpurulent mastitis associated with childbirth
8.0
14.8
33
43
O36.9
ICD-10 Finland
Maternal care for fetal problem, unspecified
7.0
14.7
36
54
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
2.0
14.6
317
2152
O86.0
ICD-10 Finland
Infection of obstetric surgical wound
24.4
13.9
19
8
MA1AE
NOMESCO Finland
Ultrasound examination of early pregnancy (before 12. postmenstrual week)
2.1
13.7
201
1161
Z34
ICD-10 Finland
Supervision of normal pregnancy
2.5
13.7
119
539
RF210
NOMESCO Finland
NA
5.1
13.4
42
87
WX322
NOMESCO Finland
Combined spinal-epidural analgesia in obstetrics
4.0
13.3
54
145
O86.1
ICD-10 Finland
Other infection of genital tract following delivery
41.0
13.2
16
*
W85
ICPC
Gestational diabetes
2.6
12.9
104
450
S44
ICPC
Skin, Preventive immunization/medic
6.7
12.8
32
50
O86.8
ICD-10 Finland
Other specified puerperal infections
+∞
12.5
12
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.9
12.2
232
1469
WX320
NOMESCO Finland
Spinalanesthesy
2.1
11.9
148
790
TQW30
NOMESCO Finland
Acupuncture
8.2
11.9
26
33
O85
ICD-10 Finland
Puerperal sepsis
66.2
11.6
13
*
O24.4
ICD-10 Finland
Diabetes mellitus arising in pregnancy
2.1
11.6
148
801
MCA10
NOMESCO Finland
Lower uterine segment caesarean section
2.0
11.0
159
904
O34.2
ICD-10 Finland
Maternal care due to uterine scar from previous surgery
2.3
10.5
100
473
67809
ICD-8 Finland
Mastitis and other disorders of lactation, Unspecified
+∞
10.4
10
*
W90
ICPC
Uncompl labour/delivery livebirth
2.2
10.3
112
562
SPAT1196
SPAT
Monitoring of normal pregnancy
2.0
9.9
146
832
SPAT1246
SPAT
Screening of depression or other psychiatric problem
2.4
9.7
88
406
MAC01
NOMESCO Finland
Rupture of aminiotic membrane for induction of labor
3.2
9.6
49
160
MWA00
NOMESCO Finland
Repair of wound dehiscence in obstetric surgery
50.7
8.7
10
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
8.4
151
916
Z36.3
ICD-10 Finland
Antenatal screening for malformations using ultrasound and other physical methods
1.6
8.4
332
2547
Z39.1
ICD-10 Finland
Care and examination of lactating mother
3.0
8.4
48
170
6768X
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Other disorders of lactation
+∞
8.3
8
*
Z36.0
ICD-10 Finland
Antenatal screening for chromosomal anomalies
2.1
8.3
96
491
O20.9
ICD-10 Finland
Haemorrhage in early pregnancy, unspecified
2.8
8.2
53
203
O70.0
ICD-10 Finland
First degree perineal laceration during delivery
5.2
8.1
24
48
Z30.1
ICD-10 Finland
Insertion of (intrauterine) contraceptive device
1.7
7.9
193
1291
IBA01
NOMESCO Finland
Diagnostic and symptom-mapping evaluation
5.1
7.8
23
46
SPAT1399
SPAT
Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.
2.0
7.8
102
550
O71.4
ICD-10 Finland
Obstetric high vaginal laceration
6.0
7.7
20
34
O80.8
ICD-10 Finland
Other single spontaneous delivery
2.1
7.4
86
443
O92.3
ICD-10 Finland
Agalactia
+∞
7.3
7
*
Z39
ICD-10 Finland
Postpartum care and examination
3.4
7.3
33
100
O99.2
ICD-10 Finland
Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium
3.1
7.3
38
128
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
1.8
7.0
124
746
O64.0
ICD-10 Finland
Obstructed labour due to incomplete rotation of fetal head
2.8
6.9
42
156
O82.10
ICD-10 Finland
Delivery by emergency caesarean section
2.0
6.9
94
517
O26.88
ICD-10 Finland
Other specified pregnancy-related conditions
3.3
6.8
32
100
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.6
6.8
376
3069
MBC30
NOMESCO Finland
Repair of partial rupture of perineum
2.8
6.8
41
152
O64.1
ICD-10 Finland
Obstructed labour due to breech presentation
3.6
6.8
29
84
O26.82
ICD-10 Finland
Exhaustion and fatigue pregnancy-related
2.6
6.7
47
190
N64.3
ICD-10 Finland
Galactorrhoea not associated with childbirth
6.3
6.5
16
26
O32.1
ICD-10 Finland
Maternal care for breech presentation
2.2
6.5
66
320
O86.4
ICD-10 Finland
Pyrexia of unknown origin following delivery
70.5
6.4
7
*
SPAT1195
SPAT
Antenatal classes
2.1
6.4
71
360
6765A
ICD-9 Finland
Other disorders of the breast associated with childbirth, and disorders of lactation, Suppressed lactation
+∞
6.3
6
*
TLW99
NOMESCO Finland
Other minor surgical procedure in gynaecology
4.2
6.3
22
54
SAA02
NOMESCO Finland
Basic examination of mouth
1.6
6.1
466
4049
G02CB01
ATC
bromocriptine; systemic
4.2
6.1
21
51
R3110
NOMESCO Finland
Psychosocial training
3.0
6.0
34
119

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
267
719
5.47
97.43
1.7
1.5
—
—
—
0
0
267
721
5.45
97.07
1.7
1.5
—
—
—
0
0
269
740
5.36
95.48
1.7
1.5
—
—
—
0
0
279
877
4.70
82.23
1.7
1.4
—
—
—
0
0
83
135
6.86
50.05
2.0
1.8
—
—
—
0
0
289
1238
3.32
49.71
3.6
2.6
0.1
0.3
e6/l
4.69
194
904
284
1221
3.28
48.29
2.7
2.2
—
—
—
0
0
303
1362
3.21
47.63
3.6
2.7
14.8
71.9
e6/l
1.67
206
1008
284
1254
3.17
45.65
3.6
2.5
—
—
—
0
0
230
951
3.14
40.64
2.8
2.3
7.3
10.1
e6/l
1.28
173
831
167
641
3.13
32.74
2.8
2.3
2.7
4.4
e6/l
2.07
107
322
87
218
4.43
32.20
2.0
2.3
—
—
—
0
0
330
1832
2.56
31.39
3.9
3.1
27.9
47.9
e6/l
1.22
218
1106
202
883
2.83
31.14
2.9
2.3
531.5
542.9
mosm/kgh2o
0.26
146
748
92
259
3.95
29.05
1.9
1.6
—
—
—
0
0
107
396
3.02
21.78
2.7
2.5
—
—
—
0
0
388
2575
2.18
21.58
2.0
1.8
—
—
—
0
0
441
3086
2.22
21.34
5.0
4.0
—
—
—
0
0
27
35
7.99
19.67
2.2
3.4
—
—
—
0
0
359
2374
2.09
19.41
1.9
1.7
—
—
—
0
0
27
38
7.36
18.34
2.2
3.3
—
—
—
0
0
377
2664
1.93
15.59
2.5
1.9
—
—
—
0
0
192
1089
2.06
14.95
1.3
1.5
—
—
—
0
0
226
1364
1.98
14.76
1.6
1.7
—
—
—
0
0
280
1862
1.86
13.34
1.8
1.8
—
—
—
0
0
90
409
2.38
11.95
1.2
1.2
—
—
—
0
0
521
4276
1.93
11.84
4.4
3.9
—
—
—
0
0
396
3014
1.75
11.30
2.2
2.1
—
—
—
0
0
72
331
2.31
9.28
2.0
2.1
4.1
4.6
umol/l
0.37
54
240
201
1326
1.73
9.12
2.4
3.2
—
—
—
0
0
172
1129
1.70
7.79
1.9
3.0
99.4
98.3
%
0.25
164
1086
579
5255
1.69
5.53
10.4
11.2
13.3
13.3
%
0.46
574
5161
140
947
1.60
5.46
2.1
2.4
63.0
86.8
ug/g
1.41
118
709
426
3647
1.45
5.09
3.3
3.0
46.4
51.7
ug/l
1.95
410
3447
29
121
2.46
4.70
1.4
1.4
—
—
—
0
0
192
1449
1.45
4.41
1.4
1.4
1.9
2.0
g/l
1.59
106
906
31
138
2.31
4.38
3.1
2.7
—
—
—
0
0
224
1755
1.41
4.15
1.3
1.3
1.8
1.4
u/ml
0.24
53
483
674
6570
3.93
4.13
14.1
14.2
7.0
6.9
e9/l
1.32
666
6433
674
6569
3.95
4.12
14.0
14.1
4.4
4.5
e12/l
1.48
666
6441
617
5789
1.71
4.04
9.1
9.2
18.4
17.7
mg/l
0.24
491
4430
673
6562
3.49
3.80
14.1
14.1
263.4
268.0
e9/l
1.35
658
6437
593
5565
1.51
3.24
5.1
5.0
1.5
1.9
mu/l
1.15
576
5311
356
3093
1.32
3.15
5.0
7.8
4.0
4.0
e9/l
0.01
300
2730
606
5721
1.54
3.14
10.3
10.2
38.9
39.5
%
1.72
557
4806
9
22
4.13
2.89
1.1
1.0
187.8
357.2
u/l
—
9
17
92
657
1.46
2.77
1.8
2.0
2.4
2.4
mmol/l
1.93
69
567
347
3038
1.29
2.76
2.6
3.1
0.0
0.0
estimate
0.50
62
641
90
643
1.46
2.70
1.4
1.6
272.5
289.7
mu/l
0.18
84
566
29
154
1.92
2.70
4.6
7.4
—
—
—
0
0
7
15
4.70
2.60
1.1
1.0
—
—
—
0
0
7
15
4.70
2.60
1.1
1.0
—
—
—
0
0
7
15
4.70
2.60
1.0
1.2
—
—
—
0
0
7
15
4.70
2.60
1.1
1.0
—
—
—
0
0
48
302
1.63
2.55
7.6
12.2
1.0
1.2
inr
1.67
12
59
564
5300
1.38
2.53
7.3
8.1
139.4
139.4
mmol/l
0.35
553
5114
345
3040
1.27
2.53
3.6
4.2
0.0
0.0
estimate
0.50
65
669
348
3072
1.27
2.50
2.9
3.1
0.0
0.0
estimate
0.00
64
655
32
182
1.80
2.44
1.1
1.3
—
—
—
0
0
400
3621
1.25
2.21
4.7
5.8
66.5
69.4
u/l
1.54
359
3379
562
5309
1.34
2.18
7.4
8.1
3.8
3.9
mmol/l
1.55
551
5104
529
4959
1.30
2.15
4.5
4.4
13.9
14.2
pmol/l
3.15
507
4675
432
3954
1.25
2.13
3.4
3.5
7.7
8.5
mm/h
1.53
416
3695
16
75
2.16
2.10
1.6
1.3
—
—
—
0
0
72
519
1.43
2.09
1.2
1.3
—
—
—
0
0
313
2778
1.23
2.00
3.8
3.7
6.1
6.0
mmol/l
0.07
236
2385
114
895
1.33
1.98
1.4
1.4
476.4
534.6
titre
0.16
22
189
133
1068
1.30
1.97
1.3
1.3
4.4
9.7
u/ml
1.11
50
449
79
586
1.39
1.97
1.2
1.3
16.5
16.8
iu/l
0.04
71
498
5
11
4.57
1.94
1.0
1.1
—
—
—
0
0
109
854
1.33
1.93
2.6
3.3
—
—
—
0
0
16
78
2.08
1.92
4.1
3.3
—
—
—
0
0
82
616
1.38
1.90
1.2
1.2
—
—
—
0
0
17
86
2.00
1.86
1.5
1.3
—
—
—
0
0
138
1129
1.28
1.78
1.3
1.3
15.5
23.5
iu/ml
1.32
31
346
307
2744
1.22
1.77
3.9
5.3
0.0
0.0
e9/l
0.31
254
2436
319
2866
1.21
1.73
3.9
5.2
2.0
2.0
e9/l
0.33
297
2601
279
2478
1.21
1.70
3.9
5.2
0.6
0.7
%
0.14
251
2315
55
394
1.43
1.69
1.1
1.2
—
—
—
0
0
64
472
1.39
1.67
1.3
1.3
326.9
229.2
miu/ml
1.13
33
248
153
1277
1.26
1.67
3.1
6.1
—
—
—
0
0
316
2846
1.21
1.65
3.9
5.6
0.2
0.2
e9/l
0.45
289
2579
305
2738
1.21
1.65
3.9
5.3
0.5
0.5
e9/l
1.43
257
2439
20
338
0.58
1.63
1.2
1.3
—
—
—
0
0
68
509
1.37
1.63
1.8
2.2
4.8
5.0
umol/l
0.15
57
405
158
1858
0.81
1.61
2.4
2.6
—
—
—
0
0
69
520
1.36
1.59
1.4
1.3
—
—
—
0
0
22
129
1.73
1.58
1.1
1.4
2.3
4.3
u/ml
—
6
55
466
4364
1.22
1.58
3.5
3.8
35.9
36.6
mmol/mol
1.18
448
4135
125
1030
1.26
1.52
2.0
2.2
4807.3
3404.0
umol/l
0.17
110
930
0
43
0.00
1.52
0.0
1.1
—
—
—
0
0
287
2583
1.19
1.46
3.9
5.1
2.7
2.6
%
0.46
260
2406
12
224
0.53
1.40
3.4
7.9
6.2
6.7
mmol/l
0.14
12
218
9
40
2.27
1.40
3.2
1.6
—
—
—
0
0
7
29
2.43
1.39
1.3
1.1
—
—
—
0
0
7
29
2.43
1.39
3.7
1.9
—
—
—
0
0
298
2702
1.18
1.38
3.8
5.0
57.2
56.6
%
0.43
272
2545
73
569
1.32
1.37
1.7
1.9
405.2
380.9
nmol/l
0.62
68
526
35
241
1.48
1.35
1.5
1.7
—
—
—
0
0
29
193
1.52
1.31
1.0
1.1
1.3
0.6
u/ml
0.49
17
77
300
2730
1.18
1.31
3.9
5.1
29.9
30.0
%
0.06
274
2571
29
194
1.52
1.29
1.1
1.1
0.1
1.3
u/ml
—
8
52
5
18
2.79
1.28
1.2
1.1
—
—
—
0
0
5
18
2.79
1.28
2.0
1.7
—
—
—
0
0
78
621
1.29
1.27
1.5
1.8
—
—
—
0
0
69
866
0.77
1.23
4.3
4.2
19.5
13.6
mg/mmol
0.28
43
571
636
6212
1.37
1.21
8.6
8.9
—
—
—
0
0
92
754
1.25
1.19
1.5
1.4
—
—
—
0
0
285
2602
1.16
1.16
4.1
5.3
7.5
7.7
%
0.67
260
2454
162
1413
1.19
1.15
1.9
2.4
54.2
54.8
u/l
0.10
149
1304
78
630
1.27
1.15
2.3
2.4
81.5
196.2
ng/l
0.57
22
284
7
31
2.27
1.10
1.6
1.3
—
—
—
0
0
30
210
1.45
1.10
1.0
1.1
7.8
5.7
u/ml
0.21
20
110
77
626
1.26
1.08
1.7
2.1
2.5
2.5
g/l
0.30
71
573
24
161
1.51
1.08
1.3
1.1
—
—
—
0
0
24
161
1.51
1.08
1.3
1.1
—
—
—
0
0
46
350
1.34
1.06
1.2
1.2
10.1
10.3
u/l
0.03
41
287
112
952
1.21
1.05
1.5
1.4
22.5
21.3
nmol/l
0.36
98
845
49
628
0.76
1.04
1.6
1.6
1142.1
1148.1
nmol/l
0.02
40
487
32
231
1.40
1.01
1.1
1.1
1.1
1.1
u/ml
0.02
20
86
10
54
1.86
0.97
1.3
1.3
6.5
6.2
g/l
—
5
40
10
54
1.86
0.97
1.3
1.3
0.3
0.4
g/l
—
5
40
10
54
1.86
0.97
1.3
1.3
—
—
—
0
0
10
54
1.86
0.97
1.3
1.3
1.8
2.9
g/l
—
5
40
322
2999
1.14
0.95
2.3
2.5
—
—
—
0
0
9
52
1.74
0.92
1.2
1.2
—
—
—
0
0
141
1240
1.17
0.92
1.5
1.5
—
—
—
0
0
10
170
0.58
0.91
1.2
1.2
—
—
—
0
0
33
245
1.36
0.91
3.3
3.7
58.7
69.9
ng/l
1.10
28
221
146
1644
0.86
0.90
2.7
3.2
0.0
0.0
estimate
1.08
64
662
68
559
1.24
0.89
1.8
2.2
26.7
23.9
%
1.06
63
476
28
203
1.40
0.88
6.3
7.6
—
—
—
0
0
31
229
1.37
0.88
1.2
2.1
21.3
20.4
s
0.59
23
187
6
30
2.01
0.87
1.0
1.0
—
—
—
0
0
19
128
1.50
0.86
1.4
1.3
283.3
345.4
ug/g
—
6
62
26
187
1.41
0.86
1.0
1.2
—
—
—
0
0
72
600
1.22
0.84
1.4
1.6
—
—
—
0
0
6
31
1.94
0.84
7.0
3.3
—
—
—
0
0
160
1432
1.15
0.83
2.3
2.7
2.3
2.3
mmol/l
0.13
151
1285
70
834
0.82
0.83
3.5
3.6
93.0
313.9
mg/l
0.88
47
566
27
198
1.38
0.81
1.6
1.3
—
—
—
0
0
187
1697
1.14
0.80
1.8
1.7
103.3
97.7
pmol/l
0.66
98
973
16
106
1.52
0.79
1.7
2.5
—
—
—
0
0
168
1518
1.14
0.77
3.0
3.7
—
—
—
0
0
0
28
0.00
0.76
0.0
1.1
—
—
—
0
0
10
59
1.71
0.76
1.0
1.0
—
—
—
0
0
35
271
1.31
0.76
1.6
1.7
—
—
—
0
0
51
417
1.24
0.73
1.2
1.2
—
—
—
0
0
41
327
1.27
0.72
2.5
3.4
—
—
—
0
0
509
4926
1.13
0.71
2.7
2.7
1.1
1.1
mmol/l
0.40
490
4682
7
40
1.76
0.71
1.0
1.5
—
—
—
0
0
24
178
1.36
0.69
1.5
1.3
25.2
36.1
nmol/l
1.68
24
163
63
533
1.20
0.66
1.3
1.3
—
—
—
0
0
516
5012
1.12
0.63
3.1
3.0
5.4
5.5
mmol/l
1.25
498
4695
8
49
1.64
0.62
1.0
1.0
—
—
—
0
0
5
30
1.67
0.61
2.4
1.5
—
—
—
0
0
178
1639
1.12
0.61
4.1
5.2
—
—
—
0
0
0
20
0.00
0.60
0.0
1.2
—
—
—
0
0
0
21
0.00
0.60
0.0
2.3
—
13.7
—
0
21
0
22
0.00
0.59
0.0
2.3
—
230.6
—
0
5
0
22
0.00
0.59
0.0
2.2
—
9.5
—
0
17
180
1661
1.11
0.59
2.2
2.2
—
—
—
0
0
16
114
1.41
0.59
7.5
8.7
23.9
23.9
mmol/l
0.00
16
108
8
54
1.49
0.57
1.8
1.8
5.1
5.4
mmol/l
—
8
44
245
2303
1.10
0.56
3.6
4.4
9.7
9.2
umol/l
0.68
230
2134
6
37
1.63
0.55
1.2
1.3
—
—
—
0
0
88
987
0.88
0.54
2.3
2.3
12211.2
7029.1
u/l
0.52
41
444
105
1163
0.89
0.53
2.7
3.3
7.5
7.7
mmol/l
0.12
86
1006
534
5214
1.11
0.53
3.0
3.0
4.7
4.7
mmol/l
0.21
523
4965
86
964
0.88
0.52
2.6
2.4
—
—
—
0
0
20
152
1.33
0.52
1.3
1.2
—
—
—
0
0
9
136
0.66
0.52
1.6
1.9
13.2
13.0
%
—
9
136
9
64
1.41
0.51
1.0
1.0
195.1
185.1
mg/l
—
9
54
6
41
1.47
0.50
1.2
1.7
—
—
—
0
0
10
67
1.50
0.50
1.1
1.0
—
—
—
0
0
11
155
0.70
0.49
3.5
6.1
23.9
24.3
mmol/l
0.15
11
146
531
5192
1.10
0.48
3.0
3.0
1.5
1.5
mmol/l
0.81
518
4940
62
543
1.16
0.47
1.4
1.3
—
—
—
0
0
249
2360
1.09
0.47
1.8
1.9
—
—
—
0
0
7
48
1.46
0.47
1.0
1.1
—
—
—
0
0
5
81
0.61
0.46
1.0
2.6
—
—
—
0
0
118
1081
1.11
0.45
1.9
1.9
101.3
181.8
u/l
0.76
113
1033
7
50
1.40
0.45
1.3
1.3
—
—
—
0
0
85
942
0.89
0.45
1.2
1.2
—
—
—
0
0
16
121
1.33
0.44
1.2
1.1
—
—
—
0
0
5
31
1.62
0.43
1.0
1.0
—
—
—
0
0
17
131
1.31
0.42
7.5
9.0
95.4
94.5
%
0.61
17
131
6
95
0.63
0.42
1.3
2.3
7.4
7.4
ph
—
6
77
37
433
0.85
0.41
1.4
2.0
21.9
34.7
u/ml
1.17
37
413
5
33
1.52
0.41
1.2
1.1
191.6
146.0
iu/ml
—
5
33
0
16
0.00
0.41
0.0
4.1
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
2.6
—
—
—
0
0
17
132
1.30
0.40
7.5
8.9
1.4
1.3
%
0.18
17
132
19
150
1.27
0.40
1.0
1.0
0.0
0.0
u/ml
—
8
30
8
60
1.34
0.40
1.0
2.0
—
—
—
0
0
0
18
0.00
0.40
0.0
4.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
26
214
1.22
0.40
2.2
2.0
2.5
4.5
iu/l
—
7
88
8
61
1.32
0.39
1.0
1.3
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
141
1315
1.09
0.39
1.6
1.8
1.3
0.8
mg/l
0.36
108
967
16
124
1.30
0.39
1.1
1.1
—
—
—
0
0
14
180
0.77
0.37
2.1
2.2
—
—
—
0
0
17
134
1.28
0.37
7.4
8.8
0.7
0.7
%
0.22
17
134
12
90
1.34
0.36
3.6
5.0
—
—
—
0
0
23
190
1.22
0.35
1.1
1.1
—
—
—
0
0
21
172
1.23
0.34
1.1
1.1
0.5
4.7
u/ml
—
10
62
68
616
1.12
0.34
1.5
1.5
—
—
—
0
0
534
5250
1.08
0.34
3.2
3.2
2.8
2.8
mmol/l
0.23
519
4968
43
378
1.15
0.34
2.9
2.2
10.4
10.4
g/l
0.00
38
348
17
136
1.26
0.34
2.8
1.9
—
—
—
0
0
6
45
1.34
0.34
3.5
1.3
24.6
41.3
mu/l
—
6
38
39
443
0.87
0.32
1.4
1.8
—
—
—
0
0
11
83
1.33
0.32
1.3
1.5
0.4
0.5
g/l
—
6
65
18
148
1.22
0.29
1.2
1.4
365.8
382.9
mg/l
0.16
18
141
8
106
0.75
0.29
1.3
2.5
24.7
24.4
mmol/l
—
8
99
7
57
1.23
0.29
1.1
1.3
—
—
—
0
0
19
158
1.21
0.28
1.1
1.1
1.4
4.9
u/ml
—
9
65
187
1954
0.94
0.28
4.5
4.8
1.2
1.2
mmol/l
0.23
155
1629
8
62
1.29
0.28
1.5
1.2
—
—
—
0
0
14
171
0.81
0.26
1.4
1.6
—
3.3
—
0
5
28
244
1.15
0.26
1.1
1.1
—
—
—
0
0
63
579
1.10
0.26
2.1
2.7
0.9
0.8
mmol/l
1.14
55
547
16
132
1.22
0.26
1.1
1.3
4.0
3.5
mmol/l
0.92
16
124
9
74
1.22
0.25
1.9
1.6
—
—
—
0
0
135
1419
0.94
0.25
1.9
2.0
2.4
2.6
mg/l
0.53
121
1218
25
286
0.87
0.24
1.4
1.3
—
—
—
0
0
15
124
1.21
0.24
1.2
1.3
—
—
—
0
0
5
40
1.25
0.22
1.8
1.2
—
94.2
—
0
5
5
40
1.25
0.22
1.4
2.1
56.2
61.8
%
—
5
40
5
41
1.22
0.22
1.0
1.3
92.7
92.3
%
—
5
41
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
23118.0
—
0
5
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
2925.7
—
0
6
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
40.8
—
0
6
0
10
0.00
0.21
0.0
1.0
—
0.2
—
0
5
0
10
0.00
0.21
0.0
1.9
—
—
—
0
0
32
356
0.89
0.21
2.7
2.8
—
—
—
0
0
116
1218
0.94
0.21
1.6
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
2.7
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
87.6
—
0
8
0
13
0.00
0.21
0.0
2.8
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
6
48
1.25
0.20
1.3
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
69
736
0.93
0.20
1.3
1.2
120.2
145.1
iu/ml
0.22
22
300
7
58
1.21
0.18
1.0
1.1
—
—
nmol/l
—
0
0
11
91
1.21
0.17
2.2
2.4
—
—
—
0
0
16
138
1.16
0.17
1.1
1.3
—
—
—
0
0
7
61
1.15
0.17
1.1
2.0
—
—
—
0
0
22
247
0.89
0.17
1.4
2.2
—
—
—
0
0
130
1351
0.95
0.17
5.7
4.2
1.1
1.0
inr
0.63
57
495
5
66
0.76
0.17
1.4
1.1
—
—
—
0
0
5
68
0.73
0.17
1.0
1.1
—
—
—
0
0
12
101
1.19
0.16
1.0
1.1
—
—
—
0
0
20
225
0.89
0.16
7.2
7.3
119.2
121.8
g/l
0.25
20
217
223
2175
1.04
0.16
2.0
2.0
—
—
—
0
0
24
216
1.12
0.15
2.7
2.1
73.8
74.7
e9/l
0.04
19
152
167
1721
0.96
0.15
4.2
4.2
1.2
1.2
mmol/l
0.11
157
1571
6
79
0.76
0.15
1.3
1.5
—
—
—
0
0
16
181
0.88
0.14
1.9
2.5
44.7
97.1
ng/l
2.02
11
153
178
1736
1.03
0.13
3.4
4.0
37.8
37.1
g/l
1.20
169
1625
35
375
0.93
0.12
2.9
4.2
0.0
0.0
%
—
5
65
122
1183
1.04
0.12
3.0
3.3
7.4
7.4
ph
0.25
29
227
11
95
1.16
0.11
1.0
1.0
—
—
—
0
0
39
414
0.94
0.11
1.5
2.1
4.1
4.3
e9/l
0.22
32
360
42
397
1.06
0.10
1.4
2.3
—
—
—
0
0
63
606
1.04
0.09
2.6
2.9
—
—
—
0
0
25
233
1.08
0.09
6.1
7.2
97.5
96.2
%
1.62
25
227
10
113
0.88
0.08
1.7
2.6
—
—
—
0
0
52
541
0.96
0.08
1.3
1.8
—
—
—
0
0
254
2507
1.02
0.08
5.4
7.1
0.0
0.0
e9/l
1.64
191
2068
7
66
1.06
0.08
1.7
1.3
—
—
—
0
0
7
67
1.05
0.08
1.7
4.2
3.5
3.7
mmol/l
—
7
61
124
1266
0.97
0.07
2.4
2.3
15.0
19.9
ng/l
0.39
49
433
87
893
0.97
0.07
1.5
1.5
156579367.6
57522542.1
pmol/l
0.27
76
791
7
84
0.83
0.07
2.0
3.2
0.6
0.9
nmol/l
—
7
71
52
539
0.96
0.07
1.3
1.8
—
—
—
0
0
231
2339
0.98
0.07
2.3
2.9
—
—
—
0
0
13
142
0.91
0.06
1.2
1.3
335.3
236.1
u/ml
—
7
94
10
111
0.90
0.06
1.1
1.2
—
—
—
0
0
116
1182
0.98
0.06
1.5
1.5
1.1
1.3
mmol/l
1.77
104
1048
39
375
1.04
0.06
2.7
3.9
0.0
0.4
%
—
5
62
130
1280
1.02
0.05
2.4
3.4
1.0
1.0
kg/l
1.06
20
210
49
505
0.97
0.05
1.3
1.9
—
—
—
0
0
53
515
1.03
0.05
2.8
3.3
4.6
4.6
pmol/l
0.08
47
460
25
238
1.05
0.05
2.9
3.5
6.0
5.8
kpa
0.54
25
232
13
120
1.08
0.05
3.1
2.7
0.9
1.3
%
0.99
13
120
40
388
1.03
0.04
2.6
4.2
0.1
0.1
%
—
8
80
53
543
0.97
0.04
1.3
1.8
—
—
—
0
0
14
131
1.07
0.03
5.9
8.8
—
—
—
0
0
60
590
1.02
0.02
1.3
1.3
—
—
—
0
0
65
660
0.98
0.02
1.2
1.2
—
—
—
0
0
22
228
0.96
0.02
2.6
3.9
2.2
9.4
ug/l
1.77
12
164
25
242
1.03
0.02
2.9
3.3
—
—
—
0
0
13
137
0.95
0.01
1.3
1.4
—
107.7
—
0
31
40
408
0.98
0.01
2.6
4.0
1.4
0.7
%
—
8
88
15
144
1.04
0.00
2.3
4.8
—
—
—
0
0
28
274
1.02
0.00
5.6
6.6
14.0
13.6
kpa
0.16
28
262
28
274
1.02
0.00
5.7
6.6
4.7
5.0
kpa
0.93
28
261
13
127
1.02
0.00
2.3
3.2
25.6
24.9
mmol/l
0.70
13
121
53
535
0.99
0.00
1.3
1.8
—
—
—
0
0
14
141
0.99
0.00
1.4
1.4
—
—
—
0
0
16
161
0.99
0.00
2.1
2.8
132.8
131.7
g/l
0.10
16
156
21
211
1.00
0.00
1.5
1.6
—
—
—
0
0
31
311
1.00
0.00
1.3
1.2
—
—
—
0
0
63
631
1.00
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
0.00
2.8
2.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
14.8
—
0
7
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
9
98
0.92
0.00
2.7
3.1
3.4
4.3
e9/l
—
9
98
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
38
380
1.00
0.00
1.1
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
9
99
0.91
0.00
2.8
3.4
56.3
57.3
%
—
9
99
0
8
0.00
0.00
0.0
2.4
—
58.8
—
0
8
0
8
0.00
0.00
0.0
1.9
—
—
—
0
0
0
5
0.00
0.00
0.0
3.8
—
—
—
0
0
0
7
0.00
0.00
0.0
9.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
151.2
—
0
7
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
68
0.88
0.00
1.2
2.5
—
—
—
0
0
7
71
0.99
0.00
1.6
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
2.0
—
243.0
—
0
5
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
8
79
1.01
0.00
1.0
1.4
—
66.9
—
0
5
8
83
0.96
0.00
1.8
3.9
1.2
1.4
mmol/l
—
8
83
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
1.2
—
0
5
0
9
0.00
0.00
0.0
1.7
—
1.2
—
0
9
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint O15_BREAST_LACT_OTHER_DIS and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_BREAST_LACT_OTHER_DIS.

N-year risk Females Males
1 No data No data
5 No data No data
10 No data No data
15 No data No data
20 No data No data

Relationships between endpoints

Index endpoint: O15_BREAST_LACT_OTHER_DIS – Other disorders of breast and lactation associated with childbirth

GWS hits: 2

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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