Risteys · O15_DELIV_OTHER

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule only females	293373
2. Check conditions None	293373
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — O83 Cause of death: ICD-10 — O83 2 out of 7 registries used, show all original rules.	651
4. Check minimum number of events None	651
5. Include endpoints None	651
6. Filter based on genotype QC (FinnGen only)	651

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	4735	4735	-
Only index persons	4711	4711	-
Unadjusted period prevalence (%)
Whole population	0.14	0.14	-
Only index persons	0.17	0.17	-
Median age at first event (years)
Whole population	-	30.27	-
Only index persons	-	30.27	-

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	651	651	-
Unadjusted period prevalence (%)	0.22	0.22	-
Median age at first event (years)	30.56	30.56	-

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
571: Matched controls
5709

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

O80.0

ICD-10 Finland

Spontaneous vertex delivery

+∞

323.0

337

O83.8

ICD-10 Finland

Other specified assisted single delivery

+∞

283.7

248

Z36.3

ICD-10 Finland

Antenatal screening for malformations using ultrasound and other physical methods

36.3

279.5

406

362

Z37.0

ICD-10 Finland

Single live birth

27.8

190.8

277

187

O83.0

ICD-10 Finland

Breech extraction

+∞

185.9

168

Z34.9

ICD-10 Finland

Supervision of normal pregnancy, unspecified

43.4

178.1

223

Z36.8

ICD-10 Finland

Other antenatal screening

147.6

170.7

175

MAG00

NOMESCO Finland

Assisted breech delivery

+∞

168.3

153

MA2HE

NOMESCO Finland

Detailed morfological ultrasound examination of fetus

19.6

162.8

270

250

Z34.8

ICD-10 Finland

Supervision of other normal pregnancy

31.6

154.3

210

103

MA2AE

NOMESCO Finland

Ultrasound examination of pregnancy (at 12. week of gestaion or later) including basic examination of fetus

14.6

133.5

251

291

O32.1

ICD-10 Finland

Maternal care for breech presentation

34.4

133.3

176

O83.1

ICD-10 Finland

Other assisted breech delivery

+∞

125.8

116

O47.0

ICD-10 Finland

False labour before 37 completed weeks of gestation

35.2

124.5

163

MAX99

NOMESCO Finland

Assistance to normal delivery

84.5

123.5

136

MA2DE

NOMESCO Finland

Detailed ultrasound examination of fetus including color doppler method

22.0

110.3

167

105

Z39.2

ICD-10 Finland

Routine postpartum follow-up

13.7

92.3

171

173

SPAT1380

SPAT

Postpartum check-up

39.0

91.4

116

6500B

ICD-9 Finland

Delivery in a completely normal case[PARTUS SINE COMPLICATIONE]

+∞

84.5

SPAT1379

SPAT

Health check-up of pregnant person

16.2

83.4

141

113

SPAT1197

SPAT

Extensive health check-up of expecting family

13.1

81.7

153

155

Z35.8

ICD-10 Finland

Supervision of other high-risk pregnancies

16.0

76.9

130

103

WX307

NOMESCO Finland

Obstetric epidural analgesia

18.9

70.5

111

O24.4

ICD-10 Finland

Diabetes mellitus arising in pregnancy

14.5

68.1

120

103

Z35.9

ICD-10 Finland

Supervision of high-risk pregnancy, unspecified

26.8

63.8

Z34.0

ICD-10 Finland

Supervision of normal first pregnancy

10.4

63.0

132

161

MAC96

NOMESCO Finland

Other induction or advancement of labour

27.9

62.4

Z32.1

ICD-10 Finland

Pregnancy confirmed

8.6

59.7

141

210

O47.1

ICD-10 Finland

False labour at or after 37 completed weeks of gestation

115.6

58.1

O81.4

ICD-10 Finland

Vacuum extractor delivery

+∞

56.2

MAB20

NOMESCO Finland

Failed external version

60.9

56.1

MA2JE

NOMESCO Finland

Ultrasound screening of fetal nuchal translucency

7.9

51.8

128

201

O30.0

ICD-10 Finland

Twin pregnancy

27.5

48.0

W78

ICPC

Pregnancy

5.8

47.1

150

330

SPAT1196

SPAT

Monitoring of normal pregnancy

14.6

46.9

O42.9

ICD-10 Finland

Premature rupture of membranes, unspecified

27.1

45.6

MA1AE

NOMESCO Finland

Ultrasound examination of early pregnancy (before 12. postmenstrual week)

5.3

44.5

154

371

Z3232

NOMESCO Finland

Midwife

5.6

43.7

142

317

O82.10

ICD-10 Finland

Delivery by emergency caesarean section

+∞

42.2

WX321

NOMESCO Finland

Acute spinal anesthesia for delivery

26.2

41.0

O84.8

ICD-10 Finland

Other multiple delivery

+∞

37.9

O80.1

ICD-10 Finland

Spontaneous breech delivery

+∞

36.9

O13

ICD-10 Finland

Gestational [pregnancy-induced] hypertension

13.4

36.7

MA5AE

NOMESCO Finland

Morphology ultrasound screening, weeks 18+0 to 21+6 of gestation

24.8

35.5

SPAT1317

SPAT

Planned health check-up monitoring, health check-up performed based on individual need

5.7

33.3

103

212

O80.8

ICD-10 Finland

Other single spontaneous delivery

+∞

32.6

MA2XE

NOMESCO Finland

Other obstetric ultrasound examination

7.9

32.5

110

O60

ICD-10 Finland

Preterm labour and delivery

11.1

31.5

NE1AG

NOMESCO Finland

MRI pelvimetry with high intensity magnet

39.4

29.7

O20.9

ICD-10 Finland

Haemorrhage in early pregnancy, unspecified

15.2

29.4

O83.2

ICD-10 Finland

Other manipulation-assisted delivery

+∞

29.4

XMA22

NOMESCO Finland

General examination of pregnant woman

9.3

27.8

SPAT1399

SPAT

Acceptance of acknowledgement of paternity of child born outside of marriage before the birth of the child at the maternity clinic. Paternity Act, Section 16.

23.1

27.3

W84

ICPC

Pregnancy high risk

13.0

26.5

MA3AE

NOMESCO Finland

Combined first trimester screening

15.9

26.4

TMA00

NOMESCO Finland

Episiotomy

13.1

26.0

Z35.2

ICD-10 Finland

Supervision of pregnancy with other poor reproductive or obstetric history

37.5

25.5

Z30.1

ICD-10 Finland

Insertion of (intrauterine) contraceptive device

3.1

24.5

156

609

O84.0

ICD-10 Finland

Multiple delivery, all spontaneous

+∞

24.1

Z36.0

ICD-10 Finland

Antenatal screening for chromosomal anomalies

11.8

23.3

O26.82

ICD-10 Finland

Exhaustion and fatigue pregnancy-related

38.1

23.2

O82.0

ICD-10 Finland

Delivery by elective caesarean section

+∞

23.1

O99.80

ICD-10 Finland

The fear of childbirth

8.5

23.0

O72.0

ICD-10 Finland

Third-stage haemorrhage

18.5

22.9

O72.1

ICD-10 Finland

Other immediate postpartum haemorrhage

27.2

22.9

Z34

ICD-10 Finland

Supervision of normal pregnancy

8.4

22.0

ZXD05

NOMESCO Finland

Urgent procedure

2.7

21.9

196

937

O41.0

ICD-10 Finland

Oligohydramnios

23.3

21.9

O14.0

ICD-10 Finland

Mild to moderate pre-eclampsia

12.6

21.3

W90

ICPC

Uncompl labour/delivery livebirth

17.4

21.2

O36.6

ICD-10 Finland

Maternal care for excessive fetal growth

9.4

20.7

SPAT1200

SPAT

Guidance for breast-feeding and breast care

26.7

20.6

Z36.4

ICD-10 Finland

Antenatal screening for fetal growth retardation using ultrasound and other physical methods

76.3

19.8

MBA30

NOMESCO Finland

Manual removal of placenta from delivered uterus

18.5

19.8

MAE00

NOMESCO Finland

Outlet vacuum delivery

8.8

19.5

TQW30

NOMESCO Finland

Acupuncture

32.6

19.4

W85

ICPC

Gestational diabetes

8.6

18.8

SPAT1189

SPAT

Other ultrasound examination during pregnancy

14.8

18.8

O72.2

ICD-10 Finland

Delayed and secondary postpartum haemorrhage

17.2

18.0

O36.5

ICD-10 Finland

Maternal care for poor fetal growth

12.0

17.7

MAC01

NOMESCO Finland

Rupture of aminiotic membrane for induction of labor

16.3

17.7

SPAT1357

SPAT

Monitoring of problem during pregnancy

15.4

17.3

O35.8

ICD-10 Finland

Maternal care for other (suspected) fetal abnormality and damage

12.1

17.2

ZXE00

NOMESCO Finland

One hour or less

2.2

16.9

251

1507

O02.1

ICD-10 Finland

Missed abortion

4.1

16.8

187

O26.6

ICD-10 Finland

Liver disorders in pregnancy, childbirth and the puerperium

15.7

16.8

O30.00

ICD-10 Finland

Twin pregnancy with separate amniotic and chorionic sacs

92.8

16.6

Z35.0

ICD-10 Finland

Supervision of pregnancy with history of infertility

7.1

16.3

O20.0

ICD-10 Finland

Threatened abortion

7.0

15.8

O48

ICD-10 Finland

Prolonged pregnancy

12.8

15.5

W29

ICPC

Pregnancy symptom/complaint other

12.8

15.5

SPAT1190

SPAT

Insertion or removal of intrauterine contraceptive device

3.8

15.4

191

O26.88

ICD-10 Finland

Other specified pregnancy-related conditions

46.3

15.1

SPAT1316

SPAT

Extensive health check-up of children and adolescents

12.9

15.0

O36.9

ICD-10 Finland

Maternal care for fetal problem, unspecified

25.8

14.8

ZXD10

NOMESCO Finland

Scheduled procedure

2.1

14.5

238

1465

O66.0

ICD-10 Finland

Obstructed labour due to shoulder dystocia

43.7

14.2

Z32.0

ICD-10 Finland

Pregnancy, not (yet) confirmed

6.7

13.9

G02BA03

ATC

plastic IUD with progestogen

2.5

13.9

119

537

MBA03

NOMESCO Finland

Curettage of uterus after delivery or abortion

6.2

13.9

MBA00

NOMESCO Finland

Vacuum aspiration from uterus after delivery or abortion

7.2

13.8

Z2221

NOMESCO Finland

Medical doctor

2.0

13.6

224

1372

65000

ICD-8 Finland

Delivery without mention of complication, Occipital presentation

+∞

13.6

SPAT1315

SPAT

Periodic health check-up of children and adolescents

7.9

13.3

O03.9

ICD-10 Finland

Spontaneous abortion, Complete or unspecified, without complication

4.1

13.2

136

OAA12

SPAT

41.1

13.2

MAC40

NOMESCO Finland

Pharmacological induction or advancement of labor

12.6

13.2

O70.1

ICD-10 Finland

Second degree perineal laceration during delivery

12.6

13.2

MBC30

NOMESCO Finland

Repair of partial rupture of perineum

15.9

12.7

Z30.2

ICD-10 Finland

Sterilization

3.0

12.7

283

TPH04

NOMESCO Finland

Cathetrisation of vein

2.4

12.6

114

529

Z35.4

ICD-10 Finland

Supervision of pregnancy with grand multiparity

132.8

12.5

N81.6

ICD-10 Finland

Rectocele

8.3

12.5

WX602

NOMESCO Finland

Repeated or continuing anesthesia shots throug a catheter

3.0

12.1

259

O02.0

ICD-10 Finland

Blighted ovum and nonhydatidiform mole

4.7

11.9

WX322

NOMESCO Finland

Combined spinal-epidural analgesia in obstetrics

15.1

11.9

LC2BE

NOMESCO Finland

Transvaginal ultrasound examination of uterus, parametria and lower abdomen

1.9

11.7

282

1957

O26.9

ICD-10 Finland

Pregnancy-related condition, unspecified

30.7

11.7

MAG10

NOMESCO Finland

Breech extraction delivery

+∞

11.5

O99.89

ICD-10 Finland

Other specified diseases and conditions complicating pregnancy, childbirth and the puerperium

9.9

11.3

G03AC03

ATC

levonorgestrel; systemic

3.1

11.2

219

Z39.1

ICD-10 Finland

Care and examination of lactating mother

11.5

11.1

QBB10

NOMESCO Finland

Major dressing of wound of skin of trunk

4.0

11.0

117

O63.1

ICD-10 Finland

Prolonged second stage (of labour)

8.0

11.0

O10.0

ICD-10 Finland

Pre-existing essential hypertension complicating pregnancy, childbirth and the puerperium

9.9

10.8

O26.7

ICD-10 Finland

Subluxation of symphysis (pubis) in pregnancy, childbirth and the puerperium

61.1

10.7

LGA00

NOMESCO Finland

Sterilisation by ligature of Fallopian tubes

61.1

10.7

O21.0

ICD-10 Finland

Mild hyperemesis gravidarum

33.2

10.4

O73.0

ICD-10 Finland

Retained placenta without haemorrhage

19.2

10.3

Z30.5

ICD-10 Finland

Surveillance of (intrauterine) contraceptive device

2.7

10.2

303

O99.2

ICD-10 Finland

Endocrine, nutritional and metabolic diseases complicating pregnancy, childbirth and the puerperium

10.3

10.1

SPAT1246

SPAT

Screening of depression or other psychiatric problem

4.5

10.1

MAC10

NOMESCO Finland

Antepartum dilatation of cervical canal

6.5

10.0

MBC10

NOMESCO Finland

Repair of obstetric laceration of vagina

17.1

9.9

Z39.0

ICD-10 Finland

Care and examination immediately after delivery

26.5

9.8

O23.5

ICD-10 Finland

Infections of the genital tract in pregnancy

101.6

9.4

MAC00

NOMESCO Finland

Rupture of amniotic membrane

+∞

9.4

O83.9

ICD-10 Finland

Assisted single delivery, unspecified

+∞

9.4

O46.9

ICD-10 Finland

Antepartum haemorrhage, unspecified

10.9

9.3

SPAT1195

SPAT

Antenatal classes

6.2

9.3

J01DA01

ATC

[U] cefalexin; systemic

1.7

9.3

356

2778

O33.9

ICD-10 Finland

Maternal care for disproportion, unspecified

15.9

9.1

MCA10

NOMESCO Finland

Lower uterine segment caesarean section

2.4

9.1

338

O99.0

ICD-10 Finland

Anaemia complicating pregnancy, childbirth and the puerperium

37.3

9.0

G02CB01

ATC

bromocriptine; systemic

5.4

9.0

O75.6

ICD-10 Finland

Delayed delivery after spontaneous or unspecified rupture of membranes

10.9

8.8

Z36.9

ICD-10 Finland

Antenatal screening, unspecified

50.8

8.7

MAB10

NOMESCO Finland

External version

50.8

8.7

Z09.0

ICD-10 Finland

Follow-up examination after surgery for other conditions

2.7

8.7

234

SPAT1391

SPAT

Counselling and guidance related to family situation

11.8

8.6

W92

ICPC

Compl labour/ delivery livebirth

7.1

8.6

O40

ICD-10 Finland

Polyhydramnios

16.6

8.6

O70.0

ICD-10 Finland

First degree perineal laceration during delivery

28.0

8.5

D82

ICPC

Teeth/gum disease

1.7

8.4

222

1538

O34.2

ICD-10 Finland

Maternal care due to uterine scar from previous surgery

3.4

8.4

125

WX230

NOMESCO Finland

Plexus blockade of nervus pudendus

+∞

8.3

O36.4

ICD-10 Finland

Maternal care for intrauterine death

17.5

8.1

SPAT1382

SPAT

Extensive health check-up at 18 months of age

33.9

8.1

C07AG01

ATC

labetalol; systemic

10.2

8.1

SPAT1192

SPAT

Gynaecological examination

2.1

8.0

100

533

O91.2

ICD-10 Finland

Nonpurulent mastitis associated with childbirth

22.4

8.0

OAA70

SPAT

22.4

8.0

112

Kela drug reimbursment

Severe psychotic and other severe mental disorders

0.3

7.9

450

O35.1

ICD-10 Finland

Maternal care for (suspected) chromosomal abnormality in fetus

5.3

7.9

O68.0

ICD-10 Finland

Labour and delivery complicated by fetal heart rate anomaly

3.8

7.9

WYA05

NOMESCO Finland

Emergency visit or other similar visit involving procedures

1.6

7.8

290

2197

N81.1

ICD-10 Finland

Cystocele

6.8

7.6

Z37.2

ICD-10 Finland

Twins, both liveborn

18.6

7.6

O42.1

ICD-10 Finland

Premature rupture of membranes, onset of labour after 24 hours

12.1

7.6

SFC01

NOMESCO Finland

Adjuvant procedure of filling therapy

1.8

7.6

145

904

O32.0

ICD-10 Finland

Maternal care for unstable lie

81.1

7.4

WX000

NOMESCO Finland

Monitoring vital functions without anesthesy

4.0

7.4

TKC20

NOMESCO Finland

Catheterisation of bladder

3.6

7.3

LEF03

NOMESCO Finland

Posterior colporrpahy with sutures for primary rectocele

16.0

7.2

SPAT1373

SPAT

Combined screening in early pregnancy

16.0

7.2

O42.0

ICD-10 Finland

Premature rupture of membranes, onset of labour within 24 hours

7.4

7.2

G01AA10

ATC

clindamycin; vaginal

1.9

7.2

120

712

SAA01

NOMESCO Finland

Simple examination of mouth

1.7

7.2

420

3557

O21.9

ICD-10 Finland

Vomiting of pregnancy, unspecified

8.1

7.1

Z30.0

ICD-10 Finland

General counselling and advice on contraception

2.2

7.0

351

N05AX12

ATC

aripiprazole; systemic

0.2

6.9

311

SAA02

NOMESCO Finland

Basic examination of mouth

1.6

6.9

385

3197

Z87.5

ICD-10 Finland

Personal history of complications of pregnancy, childbirth and the puerperium

14.0

6.9

O86.1

ICD-10 Finland

Other infection of genital tract following delivery

40.5

6.8

W94

ICPC

Puerperal mastitis

40.5

6.8

O35.9

ICD-10 Finland

Maternal care for (suspected) fetal abnormality and damage, unspecified

16.9

6.8

EB1SA

NOMESCO Finland

Dental X-ray, bite-wing X-ray on one side of the mouth

1.6

6.7

336

2707

N05AX08

ATC

risperidone; systemic

0.2

6.6

342

V220A

ICD-9 Finland

Normal pregnancy, Supervision of normal first pregnancy

7.0

6.5

N81.2

ICD-10 Finland

Incomplete uterovaginal prolapse

7.0

6.5

F29

ICD-10 Finland

Unspecified nonorganic psychosis

0.1

6.5

242

MAG96

NOMESCO Finland

Other breech delivery

70.6

6.4

N39.3

ICD-10 Finland

Stress incontinence

3.7

6.4

MA3AE

SPAT

+∞

6.3

O92.7

ICD-10 Finland

Other and unspecified disorders of lactation

+∞

6.3

O80.9

ICD-10 Finland

Single spontaneous delivery, unspecified

+∞

6.3

O90.1

ICD-10 Finland

Disruption of perineal obstetric wound

+∞

6.3

Z25.8

ICD-10 Finland

Need for immunization against other specified single viral diseases

2.1

6.2

391

O24.9

ICD-10 Finland

Diabetes mellitus in pregnancy, unspecified

7.1

6.2

SPAT1187

SPAT

General ultrasound examination in early pregnancy

27.0

6.2

MBA04

NOMESCO Finland

Curettage of uterus after delivery

27.0

6.2

G03GB02

ATC

clomifene; oral

3.9

6.0

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

1.6

6.0

169

1166

Mortality – FinRegistry

↥

Association

Association between endpoint O15_DELIV_OTHER_ASSIST and mortality.

Females

No data

Males

No data

Mortality risk

Mortality risk for people of age

years, who have O15_DELIV_OTHER_ASSIST.

N-year risk	Females	Males
1	No data	No data
5	No data	No data
10	No data	No data
15	No data	No data
20	No data	No data

Relationships between endpoints

↥

Index endpoint: O15_DELIV_OTHER_ASSIST – Other assisted single delivery

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	O15_DELIV_OTHER_ASSIST
CONTROL_EXCLUDE	O15_DELIVERY
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX	2
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	O83
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	O83
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Other assisted single delivery

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints