Arteriovenous malformation of cerebral vessels

Q17_ARTERIOVENOUS_MALFORMATION_OF_CEREBRAL_VESSELS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q28.2
  • Cause of death: ICD-10 Q28.2

2 out of 7 registries used, show all original rules.

398

4. Check minimum number of events

None

398

5. Include endpoints

None

398

6. Filter based on genotype QC (FinnGen only)

380

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 380 202 178
Unadjusted period prevalence (%) 0.08 0.07 0.08
Median age at first event (years) 54.62 52.00 57.60

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
398
Matched controls
3980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q28.2
ICD-10 Finland
Arteriovenous malformation of cerebral vessels
+∞
307.7
398
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
97.2
203.2
107
15
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
177.5
93.8
95
7
Q28.3
ICD-10 Finland
Other malformations of cerebral vessels
565.6
93.4
89
*
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
13.0
88.3
95
94
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
27.0
84.6
60
26
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.5
75.1
117
186
AA1AD
NOMESCO Finland
CT of head and brain
6.0
71.0
220
680
N03AF02
ATC
oxcarbazepine; oral
14.2
68.6
67
56
AAC40
NOMESCO Finland
Extirpation of intracranial arterio-venous malformation
+∞
67.7
63
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
14.9
63.7
60
47
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
25.3
59.7
43
19
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
18.7
54.7
45
27
PA2JT
NOMESCO Finland
Very extensive embolisation of arterio-venous malformation of the brain
+∞
47.9
45
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
14.4
46.7
44
34
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
69.5
43.3
49
8
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
227.8
40.7
41
*
PA2HT
NOMESCO Finland
Extensive embolisation of arterio-venous malformation of the brain
+∞
38.1
36
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.3
38.1
90
208
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.9
35.2
37
34
N03AX14
ATC
levetiracetam; systemic
10.0
34.5
41
45
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
11.9
34.2
36
33
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.3
33.8
47
63
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
4.0
32.1
116
370
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.8
29.9
115
381
PA2GT
NOMESCO Finland
Embolisation of arterio-venous malformation of the brain
+∞
28.5
27
*
XA800
NOMESCO Finland
Neuropsychological investigation
6.4
28.3
50
87
N03AF01
ATC
carbamazepine; oral, rectal
5.9
28.1
55
106
H93.1
ICD-10 Finland
Tinnitus
4.9
25.7
63
148
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.8
25.1
49
94
H53.4
ICD-10 Finland
Visual field defects
9.2
23.9
30
35
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
20.1
23.5
35
19
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
57.7
23.4
27
5
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
50.9
20.4
24
5
R51.80
ICD-10 Finland
Headache
3.1
20.1
101
388
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
17.6
20.0
31
19
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
20.0
18.9
28
15
G40.10
ICD-10 Finland
Simple partial seizures
69.9
17.9
20
*
I61.8
ICD-10 Finland
Other intracerebral haemorrhage
+∞
17.8
17
*
XCK00
NOMESCO Finland
Perimetry
4.4
17.5
47
118
WX882
NOMESCO Finland
High dependency care
7.3
16.7
25
36
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
16.7
141
703
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
21.1
15.3
22
11
I77.0
ICD-10 Finland
Arteriovenous fistula, acquired
+∞
14.7
14
*
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
155.5
14.6
15
*
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
28.4
14.4
19
7
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
24.8
13.9
19
8
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
4.8
13.8
32
71
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
10.6
13.7
26
26
N03AG01
ATC
valproic acid; systemic, rectal
4.0
13.6
41
112
Q28.0
ICD-10 Finland
Arteriovenous malformation of precerebral vessels
144.7
13.5
14
*
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
14.5
13.4
22
16
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
51.8
12.9
15
*
PA2AD
NOMESCO Finland
CT angiography of brain
18.1
12.6
19
11
Q28.8
ICD-10 Finland
Other specified congenital malformations of circulatory system
134.1
12.5
13
*
XX4AW, ,
NOMESCO Finland
134.1
12.5
13
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.3
12.4
51
171
R51
ICD-10 Finland
Headache
4.0
12.4
37
100
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
4.9
11.6
26
56
PA5JT
NOMESCO Finland
Embolisation of very extensive arterio-venous malformation of carotis externa area
+∞
11.5
11
*
AAF00
NOMESCO Finland
Ventriculostomy
25.9
11.2
15
6
ZXE20
NOMESCO Finland
More than three and less than five hours
2.6
11.1
74
324
Z2445
NOMESCO Finland
Psychologist
3.9
10.9
33
90
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
9.2
10.9
22
25
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
14.7
10.6
17
12
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
+∞
10.5
10
*
PA5AC
NOMESCO Finland
Angiography of arteries to the face with X-ray
+∞
10.5
10
*
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.2
10.4
43
145
ZX050
NOMESCO Finland
Stereotactic radiotherapy
17.2
9.9
15
9
AA5PD
NOMESCO Finland
CT examination of brain pefusion
17.2
9.9
15
9
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
9.7
76
357
7478X
ICD-9 Finland
Other congenital anomalies of circulatory system, Other specified anomalies of circulatory system
+∞
9.4
9
*
ZXD35
NOMESCO Finland
Usual procedure
4.3
9.3
24
58
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
37.6
9.1
11
*
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.3
8.9
35
114
D18.0
ICD-10 Finland
Haemangioma, any site
6.7
8.6
21
33
H53.2
ICD-10 Finland
Diplopia
4.5
8.5
21
49
183
Kela drug reimbursment
Lamotrigin and topiramate
11.1
8.4
15
14
Z3231
NOMESCO Finland
Registered nurse
2.0
8.3
120
715
N03AX18
ATC
lacosamide; systemic
14.9
8.3
13
9
K90
ICPC
Stroke/cerebrovascular accident
6.5
8.1
20
32
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
10.3
8.1
15
15
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
22.6
8.1
11
5
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
22.6
8.1
11
5
N18
ICPC
Paralysis/weakness
8.0
8.0
17
22
PA2CG
NOMESCO Finland
Extensive MRI examination of vessels in the head with high intensity magnet
45.9
7.7
9
*
R4150
NOMESCO Finland
Neuropsychological rehabilitation
9.1
7.6
15
17
WX002
NOMESCO Finland
Sedation and analgesia
2.1
7.6
88
482
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.4
7.5
27
83
AAC30
NOMESCO Finland
Intracranial occlusion of vascular fistula
81.6
7.4
8
*
AA9CW, ,
NOMESCO Finland
81.6
7.4
8
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.8
7.4
153
1015
N03AB02
ATC
phenytoin; systemic
7.1
7.4
17
25
H53.1
ICD-10 Finland
Subjective visual disturbances
2.9
7.3
35
128
Q82.2
ICD-10 Finland
Mastocytosis
+∞
7.3
7
*
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
+∞
7.3
7
*
Q28.1
ICD-10 Finland
Other malformations of precerebral vessels
+∞
7.3
7
*
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
20.5
7.2
10
5
ZXD10
NOMESCO Finland
Scheduled procedure
1.8
6.9
155
1051
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
4.2
6.9
18
44
N03AX09
ATC
lamotrigine; oral
3.2
6.9
27
88
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.2
6.8
12
11
WF099
NOMESCO Finland
Other radiotherapy
11.2
6.8
12
11
N19
ICPC
Speech disorder
9.6
6.8
13
14
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
23.0
6.7
9
*
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
9.5
6.3
12
13
G40.89
ICD-10 Finland
Other epilepsy
27.1
6.2
8
*
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.9
6.2
16
28
A99
ICPC
Disease/condition unspecnature/site
2.5
6.2
39
165
ZXC95
NOMESCO Finland
Use of surgical navigator
7.9
6.2
13
17
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
12.8
6.1
10
8
RS222, ,
NOMESCO Finland
8.8
6.1
12
14
ZXD05
NOMESCO Finland
Urgent procedure
1.8
6.1
129
854
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
6.1
66
352
G44.2
ICD-10 Finland
Tension-type headache
2.1
6.1
62
323
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.0
81
466

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
164
756
2.99
24.18
2.2
2.3
—
—
—
0
0
196
1018
2.82
22.81
2.5
2.3
—
—
—
0
0
96
350
3.30
20.89
11.9
9.6
0.82
1.18
mmol/l
0.51
76
288
183
974
2.63
19.52
2.3
2.1
151.09
240.27
u/l
0.70
176
921
239
1486
2.52
17.82
10.5
12.1
1.16
1.21
inr
0.44
57
444
153
813
2.43
15.62
5.5
3.6
94.18
91.41
%
0.78
147
800
275
1912
2.42
14.76
7.7
5.1
6.51
6.67
mmol/l
0.91
259
1797
234
1525
2.30
14.52
2.7
2.6
—
—
—
0
0
217
1433
2.13
12.27
8.8
6.6
1.21
1.21
mmol/l
0.91
204
1314
227
1569
2.04
10.85
8.6
7.3
1.21
1.21
mmol/l
0.56
201
1340
65
271
2.67
10.70
12.5
8.4
1.25
1.40
mmol/l
0.30
60
266
18
15
12.50
10.44
3.3
3.4
27.85
36.20
umol/l
—
13
10
81
388
2.37
9.91
9.5
7.2
105.70
104.26
mmol/l
1.93
81
388
184
1254
1.87
8.46
3.5
3.5
34.76
36.04
ng/l
0.03
132
858
57
261
2.38
7.64
14.3
9.5
—
—
—
0
0
91
524
1.95
6.78
3.5
3.6
0.83
0.82
mmol/l
0.39
84
501
131
854
1.80
6.60
5.6
4.3
—
—
—
0
0
39
168
2.46
5.96
14.4
13.6
—
—
—
0
0
46
233
2.10
4.83
3.3
3.8
4.98
4.55
kpa
0.71
46
226
131
919
1.63
4.80
3.6
2.9
—
—
—
0
0
21
77
2.82
4.42
2.0
1.2
—
—
—
0
0
266
2241
1.56
4.19
4.7
4.1
—
—
—
0
0
51
283
1.92
4.18
3.2
4.3
5.76
5.76
kpa
0.00
51
277
215
1732
1.52
4.14
6.1
6.5
11.13
11.50
umol/l
0.17
205
1643
253
2113
1.54
4.10
5.0
4.3
—
432.32
—
0
37
9
14
6.55
4.00
15.7
15.6
—
—
—
0
0
13
33
4.04
3.83
2.2
1.1
—
—
—
0
0
369
3417
2.10
3.73
22.7
15.4
139.47
139.68
mmol/l
0.78
363
3337
125
916
1.53
3.65
4.1
3.7
—
—
—
0
0
38
203
1.96
3.49
8.6
6.6
—
—
—
0
0
103
731
1.55
3.45
1.9
1.6
1.14
1.18
mg/l
0.07
91
576
121
897
1.50
3.30
4.1
3.0
0.47
0.40
e6/l
0.13
98
673
30
150
2.08
3.30
2.5
3.3
0.65
0.65
%
0.03
30
150
191
1555
1.44
3.19
6.6
6.0
8.69
8.63
%
0.09
182
1477
367
3425
1.92
3.11
22.5
15.6
3.95
3.97
mmol/l
1.09
360
3342
189
1547
1.42
3.01
6.4
5.7
3.12
2.83
%
0.91
178
1465
190
1559
1.42
2.97
6.3
6.4
—
—
—
0
0
63
412
1.63
2.96
4.9
6.1
1.03
1.04
mmol/l
0.04
57
386
45
269
1.76
2.94
1.7
2.5
5.23
7.35
ug/l
0.54
40
246
9
23
3.98
2.79
3.2
2.7
—
—
—
0
0
199
1659
1.40
2.78
5.9
5.6
0.60
0.58
e9/l
0.48
177
1442
182
1497
1.40
2.74
6.3
5.7
0.71
0.67
%
0.41
174
1415
24
119
2.08
2.72
10.1
4.6
—
—
—
0
0
199
1665
1.39
2.70
6.0
5.7
0.04
0.04
e9/l
0.47
176
1448
189
1575
1.38
2.59
6.1
5.6
56.41
57.15
%
0.38
179
1495
191
1595
1.38
2.58
6.4
5.8
27.71
27.84
%
0.06
182
1518
19
88
2.22
2.55
3.8
3.1
—
—
—
0
0
203
1716
1.37
2.53
6.2
6.1
0.19
0.19
e9/l
0.00
182
1520
29
159
1.89
2.51
4.9
4.3
—
—
—
0
0
258
2270
1.39
2.49
3.8
3.1
57.63
49.26
u/l
0.54
247
2135
87
637
1.47
2.47
3.5
2.8
523.26
555.92
mosm/kgh2o
0.79
77
542
201
1702
1.37
2.45
6.3
5.7
1.87
1.95
e9/l
0.39
179
1521
10
32
3.18
2.45
3.0
2.5
—
—
—
0
0
113
873
1.41
2.40
4.1
2.9
—
—
—
0
0
375
3564
1.90
2.39
11.7
10.2
25.59
26.54
u/l
0.59
362
3453
355
3326
1.62
2.37
19.9
13.7
23.83
22.71
mg/l
0.25
307
2628
40
247
1.69
2.36
4.5
4.2
1.22
1.23
mmol/l
0.14
35
219
70
496
1.50
2.33
2.3
2.1
—
—
—
0
0
18
85
2.17
2.32
2.1
1.2
9.92
16.68
e6/l
0.26
12
65
18
85
2.17
2.32
2.1
1.3
726.58
159.84
e6/l
0.55
12
68
142
1151
1.36
2.24
4.3
3.6
82.78
82.83
e6/l
0.00
105
807
165
1372
1.35
2.20
4.2
5.0
34.89
35.87
g/l
1.31
156
1296
45
293
1.60
2.18
2.9
4.3
—
—
—
0
0
95
724
1.41
2.16
4.4
3.4
—
—
—
0
0
26
146
1.84
2.12
4.1
3.7
—
—
—
0
0
123
985
1.36
2.07
4.0
3.1
21.38
56.95
e6/l
2.41
100
756
120
959
1.36
2.05
3.9
4.0
7.40
7.40
ph
0.16
24
181
14
63
2.27
2.03
4.6
3.5
6.54
7.64
mmol/l
1.11
14
63
8
26
3.12
2.02
1.4
1.2
—
—
—
0
0
156
1299
1.33
2.02
4.0
3.3
6.07
5.87
ph
0.39
14
108
367
3493
1.65
1.95
18.4
12.8
—
—
—
0
0
11
45
2.49
1.94
1.0
1.1
0.09
3.85
u/ml
—
5
23
46
311
1.54
1.91
2.3
2.5
36.37
46.98
u/l
0.30
40
262
14
65
2.20
1.90
4.6
3.4
1.29
1.42
mmol/l
0.45
14
65
68
500
1.43
1.88
3.3
2.9
4.08
2.07
e6/l
0.50
39
279
279
2537
1.33
1.87
8.1
7.7
76.86
77.84
u/l
0.15
267
2387
11
46
2.43
1.86
2.5
1.3
—
—
—
0
0
326
3042
1.40
1.80
4.6
4.5
1.83
2.27
mu/l
0.57
301
2788
78
593
1.39
1.79
3.0
3.4
613.21
291.23
ng/l
0.37
61
451
15
74
2.07
1.77
2.4
2.3
—
—
—
0
0
154
1300
1.30
1.76
2.4
2.1
—
—
—
0
0
87
676
1.37
1.76
3.3
2.6
4.79
4.87
e6/l
0.03
80
607
41
276
1.54
1.75
3.5
3.9
1.61
1.17
%
0.21
18
109
58
423
1.43
1.69
1.2
1.2
—
—
—
0
0
187
1626
1.28
1.68
4.1
3.5
0.00
0.00
estimate
-0.00
24
289
185
1609
1.28
1.66
4.1
3.5
0.00
0.00
estimate
0.50
27
324
111
904
1.32
1.64
1.4
1.4
—
—
—
0
0
10
44
2.30
1.56
2.0
2.8
4.06
4.07
mmol/l
—
10
44
10
44
2.30
1.56
2.0
2.8
105.20
105.30
mmol/l
—
10
44
10
44
2.30
1.56
2.0
2.8
—
—
—
0
0
12
57
2.14
1.56
1.2
2.6
17.57
15.55
%
—
6
28
36
245
1.52
1.49
3.9
3.9
0.88
0.68
%
0.13
13
84
183
1605
1.26
1.48
5.7
4.7
0.00
0.00
estimate
0.50
26
303
7
28
2.53
1.46
1.1
1.3
186.96
176.08
pmol/l
—
7
28
125
1050
1.28
1.44
2.7
2.5
52.11
61.31
u/l
1.07
119
977
37
256
1.49
1.42
3.6
3.4
—
—
—
0
0
13
67
1.97
1.40
1.2
2.2
133.86
126.90
g/l
—
7
49
11
53
2.11
1.39
1.2
1.2
30.62
20.09
u/l
0.35
11
44
35
242
1.49
1.35
3.6
4.0
0.00
0.15
%
0.74
12
75
52
389
1.39
1.33
3.0
2.6
10.70
8.64
umol/l
0.21
44
339
36
254
1.46
1.27
3.6
4.0
0.08
0.15
%
0.38
13
86
269
2492
1.25
1.25
4.1
3.8
14.71
14.74
pmol/l
0.08
247
2267
211
1910
1.22
1.20
10.1
9.6
4.01
4.06
e9/l
0.15
187
1682
14
80
1.78
1.14
5.7
5.1
—
—
—
0
0
143
1252
1.22
1.11
1.8
1.9
91.15
95.67
pmol/l
0.56
68
649
7
32
2.21
1.08
2.1
1.8
—
—
—
0
0
28
197
1.45
1.03
3.1
2.4
—
—
—
0
0
10
53
1.91
1.02
3.6
3.0
—
—
—
0
0
10
53
1.91
1.02
1.5
2.8
69.10
63.40
%
—
10
53
5
23
2.19
0.98
1.4
2.2
7.66
6.33
mmol/l
—
5
15
52
411
1.31
0.97
1.5
1.5
—
—
—
0
0
381
3725
1.53
0.94
28.5
19.9
252.65
249.08
e9/l
0.44
371
3640
381
3726
1.53
0.92
29.1
20.0
39.79
40.54
%
1.45
366
3517
77
644
1.24
0.92
1.6
1.8
456.09
32276555.89
pmol/l
1.00
68
536
6
28
2.16
0.92
1.8
1.6
—
—
—
0
0
11
63
1.77
0.91
1.5
3.7
—
—
—
0
0
381
3728
1.51
0.89
28.4
19.9
4.48
4.52
e12/l
0.92
372
3634
381
3728
1.51
0.89
28.4
19.9
6.70
6.68
e9/l
0.08
372
3630
331
3178
1.25
0.89
4.0
3.9
1.29
1.29
mmol/l
0.03
305
2941
28
208
1.37
0.80
1.4
1.2
—
—
—
0
0
0
25
0.00
0.79
0.0
1.1
—
398.95
—
0
19
7
121
0.57
0.79
1.1
1.3
0.99
1.21
g/l
—
7
115
5
97
0.51
0.79
1.2
2.0
7.78
11.34
mg/l
—
5
91
30
227
1.35
0.77
6.4
2.4
3.54
7.46
e9/l
1.36
24
186
6
34
1.78
0.76
2.3
2.3
—
—
—
0
0
9
54
1.68
0.75
1.8
2.6
—
—
—
0
0
88
765
1.19
0.73
2.1
2.0
2.73
3.07
mg/l
0.93
75
654
34
265
1.31
0.73
2.0
2.9
72.25
72.48
e9/l
0.02
28
206
108
958
1.17
0.71
3.9
3.8
5.19
9.52
mg/mmol
1.40
64
613
15
101
1.50
0.71
2.4
2.2
67.33
3270.94
u/l
—
6
36
5
26
1.93
0.71
1.0
1.0
—
—
—
0
0
5
26
1.93
0.71
1.0
1.0
20.60
52.24
mg/l
—
5
20
9
58
1.56
0.70
1.1
1.2
—
—
—
0
0
160
1466
1.15
0.69
12.2
9.3
0.00
0.00
e9/l
0.51
125
1191
7
42
1.68
0.68
5.4
3.5
—
—
—
0
0
51
427
1.22
0.63
1.2
1.2
—
—
—
0
0
29
366
0.78
0.62
1.6
1.7
—
—
—
0
0
5
30
1.67
0.61
1.0
1.1
—
0.08
—
0
6
92
816
1.17
0.61
8.4
6.8
—
—
—
0
0
331
3209
1.19
0.61
4.4
4.4
5.85
5.93
mmol/l
0.58
310
2959
0
21
0.00
0.60
0.0
1.2
—
—
—
0
0
0
22
0.00
0.59
0.0
4.6
—
—
—
0
0
0
22
0.00
0.59
0.0
1.2
—
—
—
0
0
0
23
0.00
0.58
0.0
1.6
—
—
—
0
0
70
611
1.18
0.57
1.6
1.8
—
—
—
0
0
101
911
1.15
0.54
3.5
3.3
25.40
197.61
mg/l
1.07
65
603
6
40
1.51
0.52
2.5
1.6
—
—
—
0
0
13
92
1.43
0.51
1.5
1.2
—
—
—
0
0
47
403
1.19
0.48
1.9
2.4
150.04
137.90
ug/g
0.08
35
322
143
1329
1.12
0.48
2.1
2.3
76.51
76.66
nmol/l
0.02
125
1193
46
534
0.84
0.48
1.2
1.3
17.00
10.03
u/ml
0.18
21
212
12
165
0.72
0.47
1.6
1.7
—
—
—
0
0
13
94
1.40
0.46
1.8
1.6
393.63
262.78
ug/g
—
8
57
18
138
1.32
0.46
2.8
2.3
—
—
—
0
0
5
81
0.61
0.46
1.4
1.1
—
—
—
0
0
22
175
1.27
0.44
1.8
3.0
0.19
0.11
e6/l
0.31
22
169
107
983
1.12
0.43
3.3
3.1
8.49
7.81
mmol/l
0.77
93
831
9
131
0.68
0.43
1.0
1.1
—
—
—
0
0
117
1262
0.90
0.43
2.8
2.8
—
—
—
0
0
82
742
1.13
0.43
1.5
1.5
21.72
20.83
nmol/l
0.17
72
635
17
131
1.31
0.43
1.6
1.7
—
—
—
0
0
45
390
1.17
0.42
2.1
1.6
—
—
—
0
0
8
58
1.39
0.41
12.9
2.7
—
—
—
0
0
23
186
1.25
0.41
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.2
—
175.57
—
0
15
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
0
16
0.00
0.41
0.0
2.3
—
484.71
—
0
7
50
438
1.16
0.41
2.1
2.2
24.22
22.79
%
0.27
44
377
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
301
3090
0.89
0.40
5.8
5.6
39.16
39.60
mmol/mol
0.38
284
2902
0
18
0.00
0.40
0.0
1.4
—
1.51
—
0
18
5
37
1.36
0.37
1.0
1.9
13.20
17.17
ug/l
—
5
37
15
118
1.28
0.34
1.4
1.6
—
—
—
0
0
6
45
1.34
0.34
3.2
3.0
—
—
—
0
0
114
1068
1.09
0.32
2.6
3.5
2.36
2.35
mmol/l
0.25
97
959
253
2454
1.09
0.31
4.5
4.1
10.80
11.24
mm/h
0.18
242
2266
83
895
0.91
0.31
1.6
1.7
1.32
1.41
mmol/l
0.38
71
751
342
3366
1.11
0.28
4.7
4.8
2.72
2.78
mmol/l
0.55
316
3124
61
665
0.90
0.28
3.1
2.8
0.65
0.70
ug/l
0.23
42
426
29
253
1.16
0.27
1.1
1.2
—
—
—
0
0
20
169
1.19
0.26
4.0
2.8
31.35
36.93
u/ml
0.19
20
158
32
284
1.14
0.24
1.4
1.6
—
—
—
0
0
22
253
0.86
0.23
1.2
1.4
—
—
—
0
0
5
38
1.32
0.23
1.2
1.2
—
—
—
0
0
78
732
1.08
0.22
5.2
3.7
1.02
1.02
kg/l
—
10
94
30
335
0.89
0.21
1.2
1.5
—
—
—
0
0
74
694
1.08
0.21
1.5
1.4
2.49
2.44
g/l
0.05
46
429
54
583
0.91
0.21
2.9
2.9
2.42
2.44
mmol/l
0.67
42
510
0
11
0.00
0.21
0.0
2.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.8
—
—
—
0
0
0
13
0.00
0.21
0.0
4.2
—
52.08
—
0
13
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
335
3307
1.08
0.20
4.3
4.4
4.63
4.66
mmol/l
0.26
309
3087
59
550
1.09
0.20
1.6
1.7
1078.88
1252.63
nmol/l
0.88
50
415
10
121
0.82
0.18
2.3
1.6
190.20
312.56
mu/l
—
10
110
7
61
1.15
0.17
3.4
3.1
4.23
4.42
e9/l
—
7
61
78
740
1.07
0.17
1.3
1.2
1.57
1.75
u/ml
0.05
18
201
7
63
1.11
0.17
4.4
3.4
58.57
58.06
%
—
7
63
5
70
0.71
0.17
1.6
3.9
—
—
—
0
0
25
226
1.11
0.15
3.1
3.8
63.96
76.57
ng/l
0.73
20
203
42
448
0.93
0.13
1.3
1.3
285.71
489.17
titre
—
7
96
83
863
0.95
0.13
2.2
2.7
317.68
6247.97
umol/l
3.34
74
763
19
210
0.90
0.12
1.5
2.3
—
—
—
0
0
11
95
1.16
0.11
1.5
1.2
—
—
—
0
0
14
124
1.13
0.11
2.4
2.8
—
—
—
0
0
147
1437
1.04
0.11
2.5
2.6
144.90
121.00
ug/l
0.45
138
1338
332
3293
1.05
0.10
4.3
4.3
1.46
1.45
mmol/l
0.14
307
3058
5
44
1.14
0.10
1.2
1.2
142.74
49.55
mu/l
—
5
38
5
46
1.09
0.09
2.2
1.9
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
6
54
1.11
0.09
3.5
2.6
—
—
—
0
0
38
399
0.95
0.08
1.4
1.3
—
—
—
0
0
13
117
1.11
0.08
1.0
1.3
—
—
—
0
0
13
117
1.11
0.08
1.0
1.3
—
—
—
0
0
7
67
1.05
0.08
1.0
1.5
—
—
—
0
0
52
501
1.04
0.07
1.3
1.6
—
—
—
0
0
13
118
1.11
0.07
1.0
1.3
—
—
—
0
0
42
403
1.05
0.07
1.2
1.5
—
—
—
0
0
30
285
1.06
0.07
1.5
1.4
—
—
—
0
0
8
94
0.85
0.06
1.0
1.3
—
—
—
0
0
86
880
0.97
0.06
4.8
3.7
0.00
0.01
estimate
0.80
25
296
24
227
1.06
0.06
1.3
1.4
—
—
—
0
0
54
556
0.97
0.05
1.2
1.3
19.01
34.66
iu/ml
1.21
16
185
23
218
1.06
0.05
1.4
1.3
43.16
155.16
iu/ml
—
7
89
15
160
0.94
0.04
1.0
1.1
—
—
—
0
0
12
111
1.08
0.04
1.0
1.3
—
—
—
0
0
12
112
1.07
0.03
3.2
3.6
0.16
0.19
g/l
—
7
44
230
2312
0.99
0.02
3.8
3.7
—
—
—
0
0
91
917
0.99
0.01
3.3
3.1
—
—
—
0
0
28
286
0.98
0.00
2.5
3.5
—
—
—
0
0
13
132
0.98
0.00
1.1
1.3
—
—
—
0
0
25
252
0.99
0.00
1.7
1.4
—
—
—
0
0
12
119
1.01
0.00
1.0
1.3
—
—
—
0
0
36
361
1.00
0.00
1.4
1.4
—
—
—
0
0
11
113
0.97
0.00
14.6
9.2
—
—
—
0
0
34
337
1.01
0.00
1.3
1.4
—
—
—
0
0
115
1147
1.00
0.00
5.0
4.6
1.63
2.17
ug/l
1.04
107
1040
10
104
0.96
0.00
1.1
1.2
—
—
—
0
0
34
344
0.99
0.00
3.6
4.5
5.19
19.67
ug/l
0.61
26
283
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
18.70
—
0
5
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
10.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
54
0.92
-0.00
1.0
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
82
0.98
-0.00
1.1
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
17.88
—
0
6
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
8.9
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
170.33
—
0
6
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
5
49
1.02
-0.00
1.2
1.5
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
63.00
—
0
8
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
2.47
—
0
7
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_ARTERIOVENOUS_MALFORMATION_OF_CEREBRAL_VESSELS – Arteriovenous malformation of cerebral vessels

GWS hits: 1

This endpoint is excluded (different definition than used in FinnGen).