Other congenital malformations of circulatory system

Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q28
  • Cause of death: ICD-10 Q28

2 out of 7 registries used, show all original rules.

911

4. Check minimum number of events

None

911

5. Include endpoints

None

911

6. Filter based on genotype QC (FinnGen only)

911

Control definitions (FinnGen only)

Control exclude
Q17_CONGEN_MALFO_CIRCULATO_SYSTEM

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Q2
Name in latin
Aliae malformationes congenitae systematis circulatorii

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5679 2954 2695
Only index persons 5251 2773 2478
Unadjusted period prevalence (%)
Whole population 0.08 0.08 0.08
Only index persons 0.10 0.10 0.09
Median age at first event (years)
Whole population 50.81 51.53 50.08
Only index persons 51.08 51.74 50.35

-FinnGen-

Key figures

All Female Male
Number of individuals 911 525 386
Unadjusted period prevalence (%) 0.18 0.18 0.17
Median age at first event (years) 53.93 51.63 57.06

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
817
Matched controls
8169
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Q28.3
ICD-10 Finland
Other malformations of cerebral vessels
+∞
323.0
443
*
Q28.2
ICD-10 Finland
Arteriovenous malformation of cerebral vessels
+∞
323.0
339
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
52.2
106.9
128
29
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.7
94.7
226
345
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
54.6
88.5
105
22
AAC40
NOMESCO Finland
Extirpation of intracranial arterio-venous malformation
+∞
76.3
72
*
AA1AD
NOMESCO Finland
CT of head and brain
4.4
73.2
338
1120
Q28.8
ICD-10 Finland
Other specified congenital malformations of circulatory system
+∞
67.7
64
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
27.9
66.8
92
37
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
12.6
61.5
114
104
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
8.4
60.0
141
199
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
16.4
52.5
86
58
PA2JT
NOMESCO Finland
Very extensive embolisation of arterio-venous malformation of the brain
+∞
48.4
46
*
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.9
47.8
232
752
PA2HT
NOMESCO Finland
Extensive embolisation of arterio-venous malformation of the brain
+∞
44.2
42
*
N03AF02
ATC
oxcarbazepine; oral
9.4
44.0
94
111
Q28.0
ICD-10 Finland
Arteriovenous malformation of precerebral vessels
+∞
41.0
39
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.8
40.8
148
358
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
59.4
38.7
45
8
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
13.4
38.4
68
55
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
27.1
37.2
51
20
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.5
35.3
67
63
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
81.9
35.1
39
5
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.0
34.6
81
111
XA800
NOMESCO Finland
Neuropsychological investigation
6.5
34.2
93
158
PA2GT
NOMESCO Finland
Embolisation of arterio-venous malformation of the brain
+∞
33.6
32
*
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
11.9
32.8
61
55
N03AF01
ATC
carbamazepine; oral, rectal
5.8
31.8
95
182
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
10.4
31.7
63
65
H93.1
ICD-10 Finland
Tinnitus
4.8
31.5
112
262
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
16.1
30.8
50
33
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
53.7
30.6
36
7
WX408
NOMESCO Finland
General anesthesy, balanced
2.6
30.3
291
1439
D18.0
ICD-10 Finland
Haemangioma, any site
9.5
30.2
63
71
R51.80
ICD-10 Finland
Headache
3.2
29.6
181
674
Q28.1
ICD-10 Finland
Other malformations of precerebral vessels
+∞
29.3
28
*
N03AX14
ATC
levetiracetam; systemic
8.0
28.1
65
87
Q28.9
ICD-10 Finland
Congenital malformation of circulatory system, unspecified
+∞
27.2
26
*
XCK00
NOMESCO Finland
Perimetry
4.7
27.2
98
231
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.6
23.2
83
194
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
14.7
22.8
38
27
H53.4
ICD-10 Finland
Visual field defects
9.7
22.1
45
49
I77.0
ICD-10 Finland
Arteriovenous fistula, acquired
118.2
21.7
23
*
G40.10
ICD-10 Finland
Simple partial seizures
18.5
21.0
32
18
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.9
20.9
48
64
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
78.9
20.8
23
*
R4110
NOMESCO Finland
Physiotherapy
2.3
20.6
251
1345
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
17.5
20.6
32
19
XX4AW
NOMESCO Finland
NA
27.9
20.1
27
10
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
25.7
18.3
25
10
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.6
17.7
147
644
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
16.2
91
312
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
30.7
16.2
21
7
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
48.5
16.1
19
*
AAC30
NOMESCO Finland
Intracranial occlusion of vascular fistula
+∞
15.7
15
*
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
9.4
15.3
31
34
N03AX18
ATC
lacosamide; systemic
18.2
15.2
23
13
I61.8
ICD-10 Finland
Other intracerebral haemorrhage
25.6
14.7
20
8
H53.2
ICD-10 Finland
Diplopia
4.8
14.5
48
104
WX002
NOMESCO Finland
Sedation and analgesia
2.1
14.4
179
950
N03AB02
ATC
phenytoin; systemic
10.3
14.0
27
27
PA5AC
NOMESCO Finland
Angiography of arteries to the face with X-ray
+∞
13.6
13
*
ZXC95
NOMESCO Finland
Use of surgical navigator
9.0
13.6
28
32
R20.2
ICD-10 Finland
Paraesthesia of skin
3.0
13.2
77
272
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
11.2
12.6
23
21
183
Kela drug reimbursment
Lamotrigin and topiramate
9.5
12.5
25
27
XF400
NOMESCO Finland
ECG with 12 standard connections
2.2
12.5
140
705
G44.2
ICD-10 Finland
Tension-type headache
2.2
12.3
131
645
I67.8
ICD-10 Finland
Other specified cerebrovascular diseases
38.2
12.2
15
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
12.2
143
735
N03AG01
ATC
valproic acid; systemic, rectal
3.0
12.2
70
244
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
11.3
12.1
22
20
R4150
NOMESCO Finland
Neuropsychological rehabilitation
10.3
12.0
23
23
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.8
12.0
81
312
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.2
11.9
62
202
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
47.4
11.9
14
*
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
11.3
11.6
21
19
Q27.3
ICD-10 Finland
Peripheral arteriovenous malformation
+∞
11.5
11
*
R4120
NOMESCO Finland
Occupational therapy
2.9
11.5
70
254
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
8.5
11.4
24
29
G40.6
ICD-10 Finland
Grand mal seizures, unspecified (with or without petit mal)
25.4
11.2
15
6
K90
ICPC
Stroke/cerebrovascular accident
5.7
11.1
31
56
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
8.7
11.1
23
27
XX4BW
NOMESCO Finland
NA
28.4
10.7
14
5
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.4
10.7
97
442
N18
ICPC
Paralysis/weakness
6.7
10.6
26
40
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
10.2
10.5
20
20
PA5JT
NOMESCO Finland
Embolisation of very extensive arterio-venous malformation of carotis externa area
+∞
10.4
10
*
AA9CW
NOMESCO Finland
NA
19.1
10.3
15
8
N02BE01
ATC
paracetamol; systemic, rectal
1.8
10.2
686
6040
K91
ICPC
Cerebrovascular disease
8.0
10.2
22
28
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.2
10.0
113
567
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
6.6
9.8
24
37
WX882
NOMESCO Finland
High dependency care
4.3
9.8
35
84
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.3
9.5
47
149
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
17.8
9.4
14
8
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
30.4
9.4
12
*
G40
ICD-10 Finland
Epilepsy
8.2
9.4
20
25
R51
ICD-10 Finland
Headache
2.9
9.3
56
203
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
9.7
9.3
18
19
H53.1
ICD-10 Finland
Subjective visual disturbances
2.7
9.2
63
248
WX892
NOMESCO Finland
Monitored bed care
2.5
9.1
69
287
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.2
9.1
47
154
WX110
NOMESCO Finland
Local anesthesy
1.6
8.9
544
4541
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
24.3
8.9
12
5
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
8.9
173
1066
N03AX09
ATC
lamotrigine; oral
2.9
8.6
50
178
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
3.8
8.5
35
96
ZX050
NOMESCO Finland
Stereotactic radiotherapy
7.5
8.5
19
26
Q82.2
ICD-10 Finland
Mastocytosis
91.0
8.4
9
*
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
+∞
8.3
8
*
N03AX16
ATC
pregabalin; oral
1.7
8.3
185
1189
G40.89
ICD-10 Finland
Other epilepsy
14.7
8.2
13
9
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.6
8.2
322
2399
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.4
8.2
68
297
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.5
8.0
59
242
I69.2
ICD-10 Finland
Sequelae of other nontraumatic intracranial haemorrhage
22.3
8.0
11
5
AA5PD
NOMESCO Finland
CT examination of brain pefusion
7.9
7.9
17
22
R42
ICD-10 Finland
Dizziness and giddiness
1.8
7.9
159
990
AAF00
NOMESCO Finland
Ventriculostomy
8.6
7.8
16
19
I67.9
ICD-10 Finland
Cerebrovascular disease, unspecified
10.9
7.8
14
13
TAB00
NOMESCO Finland
Lumbar puncture
2.8
7.8
49
183
H49.1
ICD-10 Finland
Fourth [trochlear] nerve palsy
15.2
7.7
12
8
I84.9
ICD-10 Finland
Unspecified hemorrhoids without complication
2.9
7.7
45
161
M79.6
ICD-10 Finland
Pain in limb
1.6
7.7
273
1978
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.7
7.6
180
1174
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
7.6
75
358
M03BX01
ATC
baclofen; systemic
4.9
7.5
23
48
PG1GT
NOMESCO Finland
Endovascular embolisation of arterio-venous malformation with radiological guidance not elsewhere classified
+∞
7.3
7
*
7478X
ICD-9 Finland
Other congenital anomalies of circulatory system, Other specified anomalies of circulatory system
+∞
7.3
7
*
4301A
ICD-9 Finland
Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACH.POST MALFORMAT.ARTERIOVENOSAM]
+∞
7.3
7
*
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.9
7.2
105
587
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.2
157
997
ABB00
NOMESCO Finland
Excision of lesion of spinal canal
20.2
7.1
10
5
L28
ICPC
Limited function/disability (L)
1.9
7.0
108
614
ZXA00
NOMESCO Finland
Right side
1.6
7.0
198
1354
Z71.8
ICD-10 Finland
Other specified counselling
1.6
6.8
176
1172
PA2CG
NOMESCO Finland
Extensive MRI examination of vessels in the head with high intensity magnet
11.1
6.8
12
11
N03AX12
ATC
gabapentin; oral
1.8
6.8
120
713
I69.8
ICD-10 Finland
Sequelae of other and unspecified cerebrovascular diseases
40.4
6.8
8
*
DFF00
NOMESCO Finland
Pure tone audiometry
2.2
6.7
69
336
RS222
NOMESCO Finland
NA
6.5
6.7
16
25
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.5
6.6
48
197
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
12.4
6.6
11
9
I63.8
ICD-10 Finland
Other cerebral infarction
8.8
6.6
13
15
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
7.5
6.4
14
19
TKC20
NOMESCO Finland
Catheterisation of bladder
2.4
6.4
52
227
PA2AD
NOMESCO Finland
CT angiography of brain
8.2
6.3
13
16
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
5.6
6.3
17
31
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
2.2
6.3
59
276
N05BA01
ATC
diazepam; systemic, rectal
1.8
6.3
104
604
R51.81
ICD-10 Finland
Facial pain NOS
4.4
6.3
21
49
PC6CC
NOMESCO Finland
Spinal angiography, very extensive
+∞
6.3
6
*
Q27.9
ICD-10 Finland
Congenital malformation of peripheral vascular system, unspecified
+∞
6.3
6
*
Q27.4
ICD-10 Finland
Congenital phlebectasia
+∞
6.3
6
*
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.6
6.2
26
74
I78.0
ICD-10 Finland
Hereditary haemorrhagic telangiectasia
26.9
6.2
8
*
R47.0
ICD-10 Finland
Dysphasia and aphasia
6.3
6.2
15
24
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
7.8
6.1
13
17
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
5.0
6.1
18
37
N05BA09
ATC
clobazam; oral
8.7
6.1
12
14
N28
ICPC
Limited function/disability (N)
5.6
6.0
16
29

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
157
373
4.88
62.74
8.7
11.0
24.4
24.4
mmol/l
0.06
151
352
393
1876
2.93
53.20
5.9
3.9
94.0
92.4
%
0.67
381
1826
218
787
3.33
47.50
8.5
8.9
0.9
1.2
mmol/l
0.42
162
634
216
785
3.30
46.46
8.5
8.9
5.1
5.1
kpa
0.36
209
758
216
785
3.30
46.46
8.5
8.9
17.3
12.6
kpa
12.38
209
760
411
2168
2.63
43.76
2.3
2.1
145.0
221.9
u/l
1.56
398
2047
421
2332
2.50
39.35
2.6
2.3
—
—
—
0
0
42
39
11.24
39.33
2.5
2.4
49.1
50.8
umol/l
0.11
37
31
623
4327
2.39
32.39
6.8
5.0
6.4
6.7
mmol/l
2.88
595
4044
329
1790
2.31
30.19
2.4
2.3
—
—
—
0
0
32
30
11.02
29.69
3.0
3.1
28.4
34.6
umol/l
1.10
24
22
503
3271
2.20
29.54
7.7
6.5
1.2
1.2
mmol/l
2.46
472
2975
526
3593
2.10
25.84
7.9
7.1
1.2
1.2
mmol/l
1.45
464
3058
93
283
3.55
25.82
3.1
2.2
21.9
21.5
s
0.26
85
260
438
2837
2.05
24.40
9.5
8.2
1.2
1.2
inr
0.11
120
844
500
3519
1.93
20.72
3.9
4.0
—
—
—
0
0
132
619
2.32
16.15
10.7
8.4
1.4
1.3
mmol/l
0.06
122
594
305
1956
1.84
15.71
4.0
3.0
—
—
—
0
0
310
2005
1.83
15.50
4.1
3.1
0.4
0.5
e6/l
0.30
240
1498
124
588
2.28
14.73
12.2
9.6
—
—
—
0
0
206
1189
1.95
14.55
4.0
3.6
0.8
0.8
mmol/l
0.29
190
1122
52
159
3.41
14.28
2.7
1.4
—
—
—
0
0
229
1395
1.86
13.61
3.5
2.7
537.3
557.0
mosm/kgh2o
0.67
192
1192
326
2212
1.74
13.44
4.1
3.2
22.2
89.4
e6/l
1.53
254
1694
370
2608
1.71
13.23
4.6
3.7
56.4
91.2
e6/l
0.97
269
1825
237
1490
1.80
12.59
3.2
2.5
5.2
6.0
e6/l
0.46
206
1311
159
886
1.96
12.28
10.0
7.6
105.4
104.1
mmol/l
2.77
159
866
205
1242
1.84
12.26
3.2
2.8
1.4
1.1
e6/l
0.77
124
713
32
78
4.22
12.13
2.6
1.5
—
—
—
0
0
52
179
3.02
11.79
2.6
1.3
18.8
10.5
e6/l
0.24
38
139
52
179
3.02
11.79
2.6
1.4
467.1
754.9
e6/l
0.17
42
143
282
1912
1.69
11.27
5.5
4.2
—
—
—
0
0
305
2112
1.67
11.24
3.8
4.0
7.4
7.4
ph
0.74
52
394
36
102
3.63
11.11
1.1
1.2
—
—
—
0
0
57
214
2.77
11.06
3.7
3.2
—
—
—
0
0
842
7642
2.34
10.90
18.6
13.4
24.1
23.0
mg/l
0.42
717
5952
400
3034
1.57
9.79
2.3
2.1
—
—
—
0
0
362
2711
1.56
9.22
3.4
3.4
29.3
36.5
ng/l
0.35
258
1816
850
7827
2.28
9.21
21.8
15.1
139.5
139.7
mmol/l
0.95
837
7626
123
695
1.89
9.00
2.2
2.4
32.3
41.6
u/l
0.68
106
595
184
1174
1.71
8.96
3.5
2.9
2.4
2.5
e6/l
0.04
102
653
293
2104
1.58
8.91
3.6
2.9
—
—
—
0
0
850
7849
2.24
8.77
21.6
15.2
3.9
4.0
mmol/l
2.14
836
7638
474
3808
1.51
8.48
6.9
5.9
0.6
0.6
e9/l
0.04
401
3309
111
623
1.89
8.28
6.8
8.2
7.5
8.9
mmol/l
1.28
106
591
482
3898
1.50
8.27
6.8
6.5
11.1
11.7
umol/l
0.50
457
3695
154
955
1.74
8.27
5.3
6.0
1.0
1.0
mmol/l
0.05
140
889
34
113
3.09
8.23
1.4
1.2
4.0
5.2
u/ml
0.18
16
45
474
3827
1.50
8.16
7.0
6.0
0.0
0.0
e9/l
1.09
399
3331
30
93
3.30
8.13
3.6
1.5
—
—
—
0
0
337
2544
1.52
7.99
6.9
6.1
—
—
—
0
0
480
3912
1.48
7.72
7.2
6.0
1.9
1.9
e9/l
0.16
406
3465
195
1310
1.62
7.70
3.3
3.6
951.4
345.0
ng/l
0.65
149
978
393
3082
1.48
7.65
5.0
5.0
35.2
35.9
g/l
1.35
371
2879
421
3373
1.46
7.21
12.2
9.2
0.0
0.0
e9/l
0.46
328
2764
24
70
3.49
7.15
3.5
3.6
—
—
—
0
0
70
353
2.06
7.09
7.3
4.8
23.7
24.2
mmol/l
0.65
64
317
480
3954
1.45
7.05
7.5
6.3
0.2
0.2
e9/l
0.14
410
3494
440
3591
1.44
6.65
7.6
6.4
8.7
8.5
%
0.55
416
3372
437
3577
1.43
6.42
7.5
6.1
3.1
2.8
%
1.08
406
3339
138
890
1.65
6.34
3.6
2.9
7.9
7.4
umol/l
0.12
118
775
425
3467
1.42
6.33
7.5
6.1
0.7
0.7
%
1.01
400
3244
20
59
3.44
5.89
1.2
1.1
231.3
228.4
mg/l
0.04
20
54
439
3639
1.40
5.79
7.4
6.0
56.5
56.8
%
0.24
413
3418
651
5777
1.44
5.78
7.8
7.6
77.1
77.6
u/l
0.14
622
5423
232
1715
1.47
5.77
2.4
1.8
1.4
1.2
mg/l
0.39
190
1291
443
3685
1.39
5.68
7.6
6.2
28.1
28.4
%
0.22
416
3446
851
8029
1.91
5.65
16.6
12.4
—
—
—
0
0
253
1915
1.44
5.53
9.9
6.8
—
—
—
0
0
102
634
1.69
5.39
6.4
4.5
1.2
2.0
mmol/l
0.93
90
502
115
738
1.64
5.38
2.2
2.0
380.6
364.6
nmol/l
0.39
108
688
67
369
1.88
5.32
13.9
12.5
—
—
—
0
0
130
865
1.59
5.24
14.4
20.5
1.1
1.2
inr
0.32
12
125
18
54
3.38
5.18
3.8
3.7
—
—
—
0
0
31
129
2.45
5.01
3.9
5.2
371.9
373.4
umol/l
0.02
26
117
860
8189
1.90
4.82
11.7
10.2
27.7
26.5
u/l
0.32
827
7924
585
5169
1.37
4.80
4.8
4.1
—
—
—
0
0
628
5616
1.38
4.75
4.1
4.1
10.1
11.3
mm/h
1.68
595
5196
95
600
1.65
4.74
1.8
2.4
4.6
7.5
ug/l
1.68
82
543
223
1694
1.42
4.69
3.5
3.5
—
—
—
0
0
22
80
2.79
4.64
2.7
2.3
—
—
—
0
0
17
53
3.25
4.63
1.2
1.2
—
—
—
0
0
593
5270
1.36
4.57
3.8
3.6
—
—
—
0
0
75
449
1.73
4.56
7.2
5.9
—
—
—
0
0
508
4412
1.34
4.55
10.8
9.3
3.9
4.1
e9/l
0.74
430
3873
352
2908
1.34
4.36
2.0
1.9
94.2
96.0
pmol/l
0.32
185
1530
28
119
2.40
4.36
1.8
1.3
89.7
60.9
mmol/l
1.58
23
102
755
7011
1.45
4.26
5.1
4.6
1.8
2.1
mu/l
0.75
710
6436
135
959
1.48
4.03
2.4
2.4
25.7
22.9
%
1.01
120
824
143
1030
1.46
3.97
2.3
2.4
2.2
2.3
g/l
1.25
133
960
150
1092
1.45
3.94
2.3
2.1
—
—
—
0
0
10
25
4.03
3.70
1.0
10.1
—
—
—
0
0
298
2450
1.32
3.69
3.5
3.4
2.4
2.4
mmol/l
0.08
260
2169
9
16
5.67
3.66
1.4
1.7
18.2
17.9
umol/l
—
9
16
30
143
2.14
3.62
1.1
1.2
—
—
—
0
0
9
17
5.34
3.51
1.1
1.0
6.3
5.7
mg/g
—
9
17
16
58
2.79
3.43
2.3
1.4
—
—
—
0
0
9
18
5.04
3.37
1.1
1.0
—
—
—
0
0
12
37
3.27
3.35
1.3
4.5
156.2
112.3
umol/l
—
5
21
385
3317
1.28
3.26
2.9
2.8
127.1
119.9
ug/l
0.23
362
3083
148
1113
1.39
3.24
2.3
2.4
14.0
13.3
umol/l
0.44
138
1031
141
1054
1.40
3.20
1.3
1.2
—
—
—
0
0
697
6477
1.32
3.19
23.5
16.2
13.7
13.6
%
0.21
689
6348
169
1302
1.37
3.19
2.9
2.9
2.4
2.4
mmol/l
0.67
141
1155
8
15
5.37
3.19
1.3
1.2
—
—
—
0
0
108
770
1.46
3.17
3.5
2.8
1.9
1.8
%
0.27
97
699
883
8584
1.93
3.05
27.8
19.6
251.1
252.3
e9/l
0.22
865
8369
883
8586
1.92
3.02
27.6
19.5
90.7
90.8
fl
0.07
875
8473
637
5867
1.29
3.00
4.3
3.9
14.7
14.7
pmol/l
0.21
596
5353
883
8587
1.92
3.00
27.6
19.5
30.3
30.3
pg
0.03
875
8473
883
8588
1.92
2.98
27.7
19.6
4.5
4.5
e12/l
2.42
864
8354
83
569
1.50
2.97
3.7
2.6
74.7
73.5
e9/l
0.08
56
440
708
6615
1.32
2.97
24.5
17.1
333.1
332.9
g/l
0.29
703
6571
883
8590
1.91
2.95
27.7
19.6
6.6
6.7
e9/l
0.21
865
8349
56
353
1.62
2.89
1.9
1.3
30.3
26.9
iu/l
0.28
49
301
416
3659
1.25
2.84
3.6
3.5
0.0
0.0
estimate
0.00
70
678
46
278
1.69
2.79
7.9
4.9
—
—
—
0
0
205
1658
1.31
2.77
1.5
1.5
20.6
20.6
nmol/l
0.01
185
1412
88
621
1.46
2.75
3.9
2.7
10.4
10.4
g/l
0.04
80
576
882
8590
1.84
2.74
27.9
19.7
134.6
136.3
g/l
2.86
875
8475
420
3711
1.24
2.72
3.7
3.5
0.0
0.0
estimate
0.80
68
660
195
1572
1.31
2.70
1.5
1.5
2.5
2.4
g/l
0.23
121
978
54
344
1.61
2.69
2.5
2.3
—
—
—
0
0
50
313
1.63
2.67
1.3
1.2
—
—
—
0
0
258
2161
1.27
2.64
1.4
1.4
—
—
—
0
0
97
703
1.43
2.64
2.6
2.5
0.2
0.2
g/l
0.03
90
663
80
562
1.46
2.57
3.8
4.1
1.2
1.2
mmol/l
0.79
70
492
414
3674
1.23
2.51
5.2
4.7
0.0
0.0
estimate
0.50
71
693
118
893
1.37
2.50
1.8
1.6
—
—
—
0
0
15
63
2.40
2.47
2.1
1.7
—
—
—
0
0
13
51
2.57
2.45
1.8
1.1
—
—
—
0
0
67
461
1.49
2.40
3.8
3.5
4.5
4.6
pmol/l
0.68
62
413
27
146
1.88
2.39
7.1
4.6
—
—
—
0
0
37
221
1.70
2.38
2.0
1.3
11.0
9.5
u/l
0.21
29
178
80
573
1.43
2.34
3.1
2.2
14.3
13.3
nmol/l
0.35
74
512
28
156
1.82
2.28
2.1
2.1
—
—
—
0
0
36
220
1.66
2.15
1.6
1.1
—
—
—
0
0
71
506
1.44
2.15
2.0
2.9
177.4
162.7
ng/l
0.12
63
458
747
7115
1.28
2.14
22.1
14.2
39.6
40.1
%
1.08
586
5332
37
229
1.64
2.11
2.4
1.8
43.2
38.0
nmol/l
0.40
37
219
5
10
5.02
2.07
1.0
1.1
—
—
—
0
0
24
132
1.84
2.05
1.2
1.1
—
—
—
0
0
69
494
1.43
2.05
2.1
1.8
1.2
1.4
g/l
0.47
63
457
6
15
4.02
2.04
2.5
2.9
—
—
—
0
0
6
15
4.02
2.04
5.0
5.7
—
—
—
0
0
40
256
1.59
2.01
1.7
2.3
378.2
301.5
ug/l
0.28
40
239
213
1801
1.24
1.97
2.3
2.1
2.6
3.0
mg/l
1.63
183
1538
75
550
1.40
1.96
3.0
4.0
80.1
82.3
ng/l
0.07
67
492
117
920
1.31
1.95
1.4
1.6
—
—
—
0
0
80
595
1.38
1.92
1.3
1.4
—
—
—
0
0
64
458
1.43
1.92
3.5
2.6
—
—
—
0
0
34
212
1.63
1.91
7.4
4.1
3.7
3.9
mmol/l
1.43
34
196
118
934
1.30
1.88
1.6
1.5
—
—
—
0
0
11
46
2.41
1.85
5.2
1.9
—
—
—
0
0
70
513
1.39
1.84
5.7
4.1
5.2
5.1
kpa
0.57
63
483
6
17
3.55
1.84
1.3
1.1
—
—
—
0
0
87
663
1.35
1.81
1.4
1.4
—
—
—
0
0
69
508
1.39
1.78
5.8
4.1
7.4
7.4
ph
—
7
63
9
36
2.51
1.74
1.0
1.2
—
—
—
0
0
8
30
2.68
1.72
1.4
1.6
—
—
—
0
0
174
1461
1.24
1.71
1.7
1.8
—
—
—
0
0
268
2351
1.20
1.70
2.8
2.5
57.4
56.1
u/l
0.22
247
2174
22
126
1.76
1.69
2.3
1.7
0.5
0.9
g/l
1.30
16
97
42
285
1.50
1.67
2.1
1.9
3.4
2.3
ug/l
0.21
36
261
32
204
1.59
1.67
6.6
9.1
1.2
1.3
mmol/l
0.33
27
183
42
286
1.49
1.65
1.2
1.2
0.3
1.3
u/ml
—
6
24
25
150
1.69
1.64
3.0
2.2
136.5
130.5
g/l
0.37
16
112
11
49
2.26
1.64
2.6
1.3
—
—
—
0
0
47
328
1.46
1.64
1.2
1.5
—
12.6
—
0
9
20
113
1.79
1.61
1.4
1.5
0.2
0.4
nmol/l
0.70
15
95
221
1917
1.20
1.57
2.9
2.9
796.4
1085.0
ng/l
1.33
193
1617
17
92
1.86
1.56
1.9
1.5
—
—
—
0
0
8
33
2.44
1.54
1.5
1.2
—
—
—
0
0
7
27
2.60
1.51
3.0
3.4
—
—
—
0
0
234
2050
1.19
1.49
1.7
1.7
1.4
1.4
mmol/l
0.26
202
1727
143
1194
1.23
1.49
1.5
1.6
—
—
—
0
0
14
72
1.96
1.49
2.9
1.3
0.4
0.3
g/l
—
9
51
14
72
1.96
1.49
2.9
1.3
3.0
2.7
g/l
—
9
51
14
72
1.96
1.49
2.9
1.3
6.6
6.9
g/l
—
9
52
118
965
1.26
1.48
1.7
2.4
177.7
117.0
ug/g
0.38
92
774
116
948
1.26
1.47
1.3
1.3
—
—
—
0
0
77
597
1.32
1.46
1.2
1.2
—
—
—
0
0
130
1077
1.24
1.46
1.3
1.3
264.4
488.2
titre
2.43
18
225
9
38
2.38
1.46
1.0
1.4
144.4
146.7
nmol/l
—
9
38
7
28
2.51
1.45
3.4
1.7
—
—
—
0
0
17
95
1.80
1.43
1.3
1.4
—
—
—
0
0
6
22
2.74
1.43
2.2
1.3
2.4
2.8
mmol/l
—
6
22
61
459
1.35
1.42
1.7
2.6
—
—
—
0
0
9
40
2.26
1.40
1.0
1.3
—
—
—
0
0
14
74
1.91
1.39
2.9
1.3
—
—
—
0
0
23
142
1.64
1.39
1.3
1.8
—
—
—
0
0
23
145
1.60
1.30
10.0
3.7
2.9
2.4
mmol/l
0.19
12
101
204
1788
1.18
1.29
1.3
1.3
1.1
1.5
u/ml
0.35
54
495
40
286
1.42
1.27
1.6
2.1
1.1
1.5
g/l
2.07
34
251
8
36
2.23
1.24
3.8
2.3
—
—
—
0
0
9
45
2.01
1.23
1.0
1.0
—
—
—
0
0
51
385
1.34
1.19
6.1
4.3
—
—
—
0
0
15
86
1.76
1.19
1.3
1.4
—
—
—
0
0
45
335
1.36
1.15
6.7
4.7
25.3
24.7
mmol/l
0.71
39
319
5
20
2.51
1.15
1.2
1.4
—
—
—
0
0
7
31
2.27
1.10
3.0
3.1
—
—
—
0
0
8
41
1.96
1.09
8.0
7.8
—
—
—
0
0
26
177
1.48
1.08
9.2
3.6
7.4
7.4
ph
0.49
21
142
11
59
1.87
1.07
2.0
1.3
6.8
6.5
mmol/l
0.09
11
54
157
1372
1.17
1.04
3.1
2.9
0.7
0.7
ug/l
0.74
108
874
793
7735
1.19
1.03
4.9
4.8
2.8
2.8
mmol/l
0.47
739
7156
65
520
1.27
1.03
1.3
1.3
302.3
229.0
u/ml
0.22
59
476
32
230
1.41
1.03
1.6
1.5
353.3
300.6
ug/g
0.85
22
143
265
2897
0.88
1.00
2.6
2.7
—
—
—
0
0
7
134
0.52
0.99
1.1
1.2
—
—
—
0
0
21
140
1.51
0.98
9.4
3.1
—
—
—
0
0
762
7417
1.17
0.97
4.3
4.4
5.8
5.9
mmol/l
0.77
710
6800
22
149
1.49
0.96
1.1
1.9
—
—
—
0
0
45
347
1.31
0.95
3.9
3.3
—
—
—
0
0
194
1737
1.15
0.94
4.2
4.5
—
—
—
0
0
67
546
1.25
0.93
1.4
1.2
86.2
146.8
iu/ml
1.07
26
230
36
271
1.34
0.90
2.5
2.2
127.0
3752.4
u/l
1.71
16
109
12
71
1.70
0.89
1.2
1.2
—
—
—
0
0
8
42
1.91
0.88
1.0
1.0
—
—
—
0
0
75
624
1.22
0.87
3.3
4.4
1.4
1.0
%
0.22
22
197
717
6965
1.14
0.87
5.6
5.5
38.5
39.6
mmol/mol
2.82
679
6490
22
153
1.45
0.86
1.1
1.1
0.1
2.6
u/ml
—
9
63
16
104
1.55
0.85
1.1
1.0
5.1
4.3
u/ml
—
7
35
22
308
0.71
0.84
1.0
1.1
—
—
—
0
0
40
310
1.30
0.84
1.3
1.5
—
—
—
0
0
75
629
1.21
0.81
3.3
3.6
—
—
—
0
0
14
89
1.58
0.81
4.1
1.6
32.4
32.7
pg
0.07
14
89
231
2115
1.12
0.80
3.8
3.6
—
—
—
0
0
42
529
0.78
0.80
1.9
1.4
—
—
—
0
0
52
420
1.25
0.80
1.3
1.2
—
—
—
0
0
68
566
1.22
0.80
3.3
4.2
0.8
0.5
%
0.23
15
139
20
139
1.45
0.79
1.2
1.0
9.7
5.3
u/ml
0.48
12
67
40
313
1.29
0.79
1.3
1.5
—
—
—
0
0
42
331
1.28
0.79
1.8
1.7
—
—
—
0
0
66
549
1.22
0.78
3.4
4.6
0.0
0.7
%
0.63
16
149
40
314
1.29
0.77
1.3
1.5
—
—
—
0
0
36
279
1.30
0.77
2.6
2.6
—
—
—
0
0
100
870
1.17
0.74
1.3
1.3
—
—
—
0
0
27
202
1.35
0.73
2.0
1.9
1.9
5.2
iu/l
—
9
67
71
600
1.20
0.73
3.2
3.5
—
—
—
0
0
15
100
1.51
0.73
1.1
1.2
—
—
—
0
0
7
39
1.80
0.72
1.3
1.7
—
—
—
0
0
10
60
1.67
0.72
1.0
1.0
—
—
—
0
0
19
134
1.43
0.71
5.1
3.4
3.9
4.4
e9/l
0.34
19
134
9
57
1.58
0.71
18.4
6.6
9.6
10.6
%
—
9
57
5
26
1.93
0.70
2.4
1.8
—
—
—
0
0
69
585
1.19
0.69
3.4
4.5
0.1
0.1
%
0.13
19
178
214
1971
1.11
0.68
3.9
3.8
0.0
0.0
estimate
1.08
69
672
38
305
1.26
0.64
1.5
1.6
—
—
—
0
0
37
296
1.26
0.64
1.3
1.5
—
—
—
0
0
14
95
1.48
0.64
1.4
1.2
—
—
nmol/l
—
0
0
16
112
1.44
0.63
1.1
1.0
6.8
5.0
u/ml
—
6
39
776
7615
1.13
0.63
4.4
4.3
4.7
4.7
mmol/l
0.48
724
7091
13
188
0.69
0.63
1.7
1.7
5518.0
14909.1
e6/l
—
6
143
19
138
1.38
0.63
5.4
3.8
57.8
57.4
%
0.06
19
138
31
244
1.28
0.62
1.3
1.5
—
—
—
0
0
8
50
1.61
0.61
1.1
1.2
4.7
6.4
ug/l
—
8
39
0
20
0.00
0.60
0.0
2.5
—
—
—
0
0
11
163
0.67
0.60
4.3
3.8
25.2
25.1
mg/l
—
6
99
747
7321
1.11
0.60
4.1
3.9
1.3
1.3
mmol/l
0.52
693
6758
0
23
0.00
0.58
0.0
1.3
—
22.9
—
0
15
7
113
0.62
0.58
3.6
3.0
0.7
0.8
nmol/l
—
7
86
38
311
1.23
0.56
1.3
1.5
—
—
—
0
0
6
37
1.63
0.55
1.0
1.1
—
—
—
0
0
38
312
1.23
0.55
3.8
3.7
25.4
25.1
mmol/l
0.21
38
306
19
142
1.35
0.54
3.7
2.4
17.2
16.4
%
0.29
13
72
12
82
1.47
0.54
1.0
1.1
—
—
—
0
0
14
101
1.39
0.49
3.2
1.7
—
—
—
0
0
14
101
1.39
0.49
3.2
1.7
—
—
—
0
0
14
101
1.39
0.49
3.2
1.7
—
—
—
0
0
14
101
1.39
0.49
5.8
2.6
—
—
—
0
0
14
101
1.39
0.49
3.2
1.7
—
—
—
0
0
19
145
1.32
0.49
1.3
1.5
—
112.5
—
0
27
80
711
1.14
0.48
2.9
4.3
—
—
—
0
0
16
119
1.35
0.48
2.3
1.7
—
—
—
0
0
8
117
0.68
0.46
1.9
1.5
—
—
—
0
0
8
118
0.68
0.46
1.9
2.8
4.4
37.8
u/ml
—
8
112
28
228
1.24
0.45
1.1
1.2
—
—
—
0
0
769
7579
1.09
0.43
4.4
4.3
1.5
1.5
mmol/l
0.04
717
7022
14
104
1.35
0.43
3.0
2.4
—
—
—
0
0
17
131
1.30
0.42
1.1
1.1
1.7
1.9
u/ml
—
9
55
5
33
1.52
0.41
1.0
1.1
—
—
—
0
0
0
16
0.00
0.41
0.0
8.8
—
—
—
0
0
0
16
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
3.4
—
—
—
0
0
245
2327
1.07
0.40
4.8
4.7
1.8
2.4
ug/l
2.00
224
2102
5
34
1.47
0.40
1.0
4.2
—
—
—
0
0
38
442
0.85
0.39
1.5
1.7
—
—
—
0
0
18
143
1.26
0.37
1.2
1.1
—
—
—
0
0
22
180
1.23
0.36
3.4
2.5
91.9
105.7
ug/min
0.10
12
109
46
522
0.87
0.36
1.4
1.4
—
—
—
0
0
18
144
1.26
0.35
5.2
4.0
138.8
1970.1
u/ml
0.56
18
136
11
82
1.35
0.34
2.5
2.6
—
—
—
0
0
11
144
0.76
0.33
1.2
1.3
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
—
11.4
—
0
7
75
820
0.91
0.32
1.4
1.3
—
—
—
0
0
6
47
1.28
0.32
1.0
1.0
189.8
266.6
ng/l
—
6
30
11
83
1.33
0.32
2.5
2.6
105.9
105.0
mmol/l
0.42
11
83
11
83
1.33
0.32
2.5
2.6
4.1
4.1
mmol/l
0.08
11
83
243
2329
1.06
0.31
3.2
3.2
8.3
7.8
mmol/l
0.73
206
1963
222
2122
1.06
0.31
3.4
3.3
53.0
303.8
mg/l
2.17
138
1357
172
1631
1.07
0.31
4.0
3.7
1.0
1.0
kg/l
0.17
19
207
132
1241
1.07
0.30
1.7
1.7
1022.5
1188.3
nmol/l
1.45
99
932
16
129
1.24
0.30
4.4
2.5
—
—
—
0
0
79
728
1.09
0.29
4.1
4.5
9.7
26.8
ug/l
0.78
58
607
233
2237
1.06
0.28
4.0
4.0
6.1
8.0
mg/mmol
0.49
143
1412
11
85
1.30
0.28
1.0
1.3
—
—
—
0
0
19
160
1.19
0.25
1.3
1.5
—
—
—
0
0
9
76
1.19
0.24
2.1
2.1
—
—
—
0
0
12
96
1.25
0.24
6.6
4.1
—
—
—
0
0
81
755
1.08
0.24
1.5
1.6
—
—
—
0
0
28
247
1.14
0.23
1.2
1.3
216.5
249.4
miu/ml
0.21
16
115
0
11
0.00
0.21
0.0
1.0
—
172.0
—
0
11
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
12.0
—
0
5
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
20
173
1.16
0.21
1.1
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
10.1
—
—
—
0
0
6
48
1.25
0.20
1.0
1.0
770.7
614.7
ng/l
—
6
31
83
879
0.94
0.19
1.9
1.7
—
—
—
0
0
142
1363
1.05
0.19
1.2
1.3
15.3
35.3
iu/ml
4.30
37
424
85
805
1.06
0.18
1.2
1.4
—
—
—
0
0
12
100
1.20
0.18
1.4
1.2
—
—
—
0
0
7
59
1.19
0.18
1.1
1.2
—
—
—
0
0
7
60
1.17
0.18
1.0
1.4
—
—
—
0
0
7
60
1.17
0.18
1.0
1.1
—
—
—
0
0
11
91
1.21
0.17
2.1
2.5
—
—
—
0
0
155
1495
1.04
0.17
1.5
1.6
447.0
38591302.8
pmol/l
1.92
133
1249
27
243
1.11
0.17
1.6
1.4
0.2
0.2
g/l
0.29
27
231
15
129
1.17
0.17
1.7
1.6
—
—
—
0
0
18
158
1.14
0.16
1.7
4.3
—
—
—
0
0
204
1985
1.04
0.15
2.9
2.7
4486.2
6884.5
umol/l
0.35
176
1733
14
161
0.87
0.15
1.6
1.7
—
—
—
0
0
198
2031
0.97
0.14
3.5
3.1
—
—
—
0
0
22
200
1.10
0.12
1.2
1.1
—
—
—
0
0
15
133
1.13
0.12
1.1
1.1
—
12.4
—
0
10
11
95
1.16
0.11
1.5
1.3
—
—
—
0
0
14
157
0.89
0.11
1.4
1.4
—
—
—
0
0
38
358
1.06
0.10
1.0
1.1
—
—
—
0
0
14
156
0.90
0.10
1.4
1.4
—
—
—
0
0
54
516
1.05
0.10
1.2
1.2
—
—
—
0
0
12
106
1.13
0.10
1.6
1.7
—
—
—
0
0
5
46
1.09
0.09
1.2
3.8
—
60.5
—
0
8
6
56
1.07
0.08
1.0
1.2
—
2.6
—
0
19
6
58
1.03
0.08
1.0
1.1
—
—
—
0
0
5
61
0.82
0.08
1.8
1.6
—
—
—
0
0
80
776
1.03
0.08
1.5
1.4
—
—
—
0
0
7
65
1.08
0.08
1.9
1.6
0.9
1.0
g/l
—
7
65
7
80
0.87
0.07
1.4
1.2
—
—
—
0
0
7
84
0.83
0.07
4.6
2.8
—
—
—
0
0
55
531
1.04
0.07
4.1
2.9
3.7
4.1
e9/l
0.77
43
423
23
216
1.07
0.07
1.3
2.2
10.8
11.5
mg/l
0.14
23
198
14
128
1.10
0.06
1.4
1.4
—
—
—
0
0
26
274
0.95
0.06
3.3
4.0
0.4
0.3
g/l
0.22
14
116
14
130
1.08
0.04
1.2
1.2
—
—
—
0
0
25
239
1.05
0.04
13.9
9.3
—
—
—
0
0
15
159
0.94
0.03
1.4
1.5
—
—
—
0
0
13
138
0.94
0.02
4.3
3.0
—
—
—
0
0
15
154
0.97
0.00
1.0
1.1
—
—
—
0
0
26
264
0.98
0.00
1.3
1.3
—
—
—
0
0
131
1305
1.00
0.00
1.3
1.3
14.6
12.1
u/ml
0.13
57
520
19
188
1.01
0.00
1.5
1.3
—
—
—
0
0
21
212
0.99
0.00
1.2
2.0
—
—
—
0
0
15
153
0.98
0.00
1.0
1.1
—
—
—
0
0
18
181
0.99
0.00
6.3
4.3
—
—
—
0
0
14
141
0.99
0.00
1.0
1.2
—
—
—
0
0
26
255
1.02
0.00
1.7
1.4
1.1
1.2
g/l
0.50
26
240
16
160
1.00
0.00
1.3
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
326.8
—
0
6
6
68
0.88
0.00
1.5
2.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
7
79
0.89
0.00
1.1
8.7
5.9
7.1
mmol/l
—
7
66
0
6
0.00
0.00
0.0
5.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
5.7
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
2.5
—
296.5
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
178.8
—
0
6
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
5
50
1.00
0.00
1.8
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM and mortality.

Females

Parameter HR [95% CI] p-value
Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM 1.412 [1.2, 1.67] < 0.001
Birth year 0.995 [0.99, 1.0] 0.218

During the follow-up period (1.1.1998 — 31.12.2019), 247 out of 2415 females with Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM died.

Males

Parameter HR [95% CI] p-value
Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM 1.509 [1.28, 1.78] < 0.001
Birth year 0.989 [0.98, 1.0] 0.02

During the follow-up period (1.1.1998 — 31.12.2019), 309 out of 2209 males with Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM died.

Mortality risk

Mortality risk for people of age

years, who have Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM.

N-year risk Females Males
1 0.111% 0.301%
5 0.689% 1.751%
10 1.803% 4.426%
15 3.836% 8.529%
20 6.932% 14.452%

Relationships between endpoints

Index endpoint: Q17_OTHER_CONGEN_MALFO_CIRCULATO_SYSTEM – Other congenital malformations of circulatory system

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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