Malignant neoplasm of renal pelvis, excluding all cancers (controls excluding all cancers)

C3_RENAL_PELVIS_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C65
  • Hospital discharge: ICD-9 1891
  • Hospital discharge: ICD-8 1891
  • Cause of death: ICD-10 C65
  • Cause of death: ICD-9 1891
  • Cause of death: ICD-8 1891
  • Cancer registry: Topography ICD-O-3 C65
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

405

4. Check minimum number of events

None

405

5. Include endpoints

None

405

6. Filter based on genotype QC (FinnGen only)

405

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of renal pelvis, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 405 107 298
Unadjusted period prevalence (%) 0.11 0.04 0.13
Median age at first event (years) 71.09 70.35 71.35

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
173
Matched controls
1729
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
C65
ICD-10 Finland
Malignant neoplasm of renal pelvis
+∞
209.7
156
*
8120/3-C65.9
ICD-O-3
Transitional cell carcinoma, NOS, of renal pelvis
+∞
189.0
145
*
UKC02
NOMESCO Finland
Cystoscopy
40.9
91.9
143
180
D41.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Renal pelvis
+∞
62.3
56
*
KAC20
NOMESCO Finland
Nephroureterectomy
+∞
61.1
55
*
R31
ICD-10 Finland
Unspecified haematuria
20.3
60.1
102
114
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
55.2
50
*
KAC21
NOMESCO Finland
Percutaneous endoscopic nephroureterectomy
+∞
52.9
48
*
130
Kela drug reimbursment
Malignant tumour
+∞
49.4
45
*
C64.88
ICD-10 Finland
Other malignant neoplasm of kidney, except renal pelvis
+∞
40.2
37
*
KCD02
NOMESCO Finland
Transurethral resection of bladder
441.0
36.4
35
*
D41.0
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Kidney
73.6
36.0
40
7
C67.9
ICD-10 Finland
Malignant neoplasm: Bladder, unspecified
+∞
29.0
27
*
H02AB02
ATC
dexamethasone; systemic
165.8
27.5
28
*
A04AA02
ATC
granisetron; systemic, transdermal
+∞
26.8
25
*
UKA02
NOMESCO Finland
Retrograde ureteronephroscopy
303.8
26.5
26
*
WX302
NOMESCO Finland
Thoracal epidural anesthesy
41.5
25.3
31
9
UKC05
NOMESCO Finland
Cystoscopy and bladder biopsy
+∞
24.6
23
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
22.4
21
*
B01AB10
ATC
tinzaparin; parenteral
15.9
21.9
36
28
A03FA01
ATC
metoclopramide; systemic, rectal
8.3
21.7
52
85
C66
ICD-10 Finland
Malignant neoplasm of ureter
+∞
21.3
20
*
D41.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Bladder
118.8
20.0
21
*
KBV02
NOMESCO Finland
Cystoscopic insertion of stent into ureter
18.8
19.7
30
19
KCD32
NOMESCO Finland
Cystoscopic destruction of tumour of bladder
+∞
19.1
18
*
KCD05
NOMESCO Finland
Excision of bladder lesion during urinary tract endoscopy with photodynamic diagnosis (PDD)
212.0
18.9
19
*
JN4AD
NOMESCO Finland
Body CT examination
14.3
18.7
32
27
JN4BD
NOMESCO Finland
Extensive body CT
12.2
18.4
34
34
UKB02
NOMESCO Finland
Retrograde ureteroscopy
23.3
18.4
26
13
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
+∞
18.0
17
*
Z51.5
ICD-10 Finland
Palliative care
14.9
18.0
30
24
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
13.7
17.9
31
27
KH1CD
NOMESCO Finland
Very extensive urinary tract ultrasound examination
187.3
16.8
17
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
15.9
15
*
B02AA02
ATC
tranexamic acid; systemic
7.7
15.0
36
57
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
14.8
14
*
WX408
NOMESCO Finland
General anesthesy, balanced
4.6
14.8
59
175
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.7
13.8
42
92
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
13.7
13
*
7126
FHL
Nephroureterectomy
+∞
12.7
12
*
TPH07
NOMESCO Finland
Cathetrisation of artery
5.3
12.5
40
92
N02AA05
ATC
oxycodone; systemic
4.5
11.8
46
130
C67.2
ICD-10 Finland
Malignant neoplasm: Lateral wall of bladder
+∞
11.6
11
*
C64
ICD-10 Finland
Malignant neoplasm of kidney, except renal pelvis
+∞
11.6
11
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
+∞
11.6
11
*
ZX136
NOMESCO Finland
Intravesicalis
+∞
11.6
11
*
KC1GB
NOMESCO Finland
Cystography with X-ray
+∞
11.6
11
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
11.6
11
*
8000/3-C65.9
ICD-O-3
Neoplasm, malignant of renal pelvis
+∞
11.6
11
*
116
Kela drug reimbursment
Prostate cancer
+∞
11.6
11
*
KAC10
NOMESCO Finland
Total nephrectomy with capsule
128.2
11.6
12
*
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
3.9
11.4
52
170
U06
ICPC
Haematuria
15.3
11.3
18
13
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
7.2
11.2
27
43
1891C
ICD-9 Finland
Malignant neoplasm of kidney and other and unspecified urinary organs, Renal pelvis[NEOPLASMA MALIGNUM PELVIS RENIS,MUU/TARK MÄÄR SYÖPÄ]
+∞
10.5
10
*
8130/3-C65.9
ICD-O-3
Papillary urothelial carcinoma of renal pelvis
+∞
10.5
10
*
JN4CD
NOMESCO Finland
Very extensive body CT
18.1
10.1
15
9
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
9.5
9
*
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
+∞
9.5
9
*
J01MA02
ATC
ciprofloxacin; systemic
2.8
9.5
87
460
B01AB05
ATC
enoxaparin; parenteral
2.9
8.9
66
302
QAE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in head or neck
10.9
8.7
16
16
KH1AD
NOMESCO Finland
CT of urinary organs
9.3
8.5
17
20
ZXE20
NOMESCO Finland
More than three and less than five hours
4.0
8.5
35
103
KAC11
NOMESCO Finland
Total nephrectomy with capsule, transcutaneous
94.5
8.5
9
*
8090/3-C44.9
ICD-O-3
Basal cell carcinoma, NOS, of skin, NOS
+∞
8.4
8
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
8.4
8
*
A04AA55
ATC
palonosetron, combinations; systemic
+∞
8.4
8
*
J01EA01
ATC
trimethoprim; systemic
3.0
8.1
54
228
WZC30
NOMESCO Finland
Teaching
5.1
8.1
25
55
A04AA01
ATC
ondansetron; systemic, rectal
16.0
7.8
12
8
KH1BD
NOMESCO Finland
Extensive urinary tract CT examination
47.1
7.8
9
*
WX402
NOMESCO Finland
General anaesthesia
4.3
7.5
28
75
WX725
NOMESCO Finland
Noninvasive ventilation
9.0
7.5
15
18
L02AE02
ATC
leuprorelin; implant, parenteral
83.5
7.5
8
*
WW500
NOMESCO Finland
Blood transfusion
11.6
7.4
13
12
C67.0
ICD-10 Finland
Malignant neoplasm: Trigone of bladder
+∞
7.3
7
*
D41.2
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Ureter
+∞
7.3
7
*
ZX090
NOMESCO Finland
Other technic of radiotherapy
+∞
7.3
7
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
7.1
7.3
17
26
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
21.1
7.2
10
5
JN3BD
NOMESCO Finland
Extensive abdominal CT
4.0
7.1
28
79
1530
FHL
Urethrocystoscopy
8.1
7.1
15
20
N02AX02
ATC
tramadol; systemic, rectal
2.4
7.1
81
463
ZXC15
NOMESCO Finland
Use of photodynamic technique
41.7
6.8
8
*
TKW99
NOMESCO Finland
Other minor surgical procedure in urology
41.7
6.8
8
*
XX3DW
NOMESCO Finland
Time consuming IT work
5.5
6.7
19
38
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
72.4
6.5
7
*
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
6.3
6
*
PJD43
NOMESCO Finland
Excision of aortic lymph nodes
+∞
6.3
6
*
R82.8
ICD-10 Finland
Abnormal findings on cytological and histological examination of urine
+∞
6.3
6
*
U75
ICPC
Malignant neoplasm of kidney
+∞
6.3
6
*
L03AA02
ATC
filgrastim; parenteral
+∞
6.3
6
*
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
6.3
6
*
WC305
NOMESCO Finland
Simple therapy of local tumor recidive with biomodifiers
+∞
6.3
6
*
115
Kela drug reimbursment
Breast cancer
+∞
6.3
6
*
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
+∞
6.3
6
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.6
6.2
28
89
TPH04
NOMESCO Finland
Cathetrisation of vein
2.7
6.1
44
194

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: C3_RENAL_PELVIS_EXALLC – Malignant neoplasm of renal pelvis, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded (different definition than used in FinnGen).