No definition available.
Haemorrhagic disorder due to circulating anticoagulants
EFO MESH Endpoint Browser PheWeb
D3_HAEMORRHAGCIRGUANTICO
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
496 |
4. Check minimum number of eventsNone |
496 |
5. Include endpointsNone |
496 |
6. Filter based on genotype QC (FinnGen only) |
474 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Perturbatio haemorrhagica ex anticoagulantibus circulantibus
Similar endpoints
↥List of similar endpoints to
Haemorrhagic disorder due to circulating anticoagulants
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Bleeding
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4217 | 1891 | 2271 |
| Only index persons | 3038 | 1409 | 1629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 78.36 | 81.68 | 75.74 |
| Only index persons | 79.55 | 82.39 | 77.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 474 | 173 | 301 |
| Unadjusted period prevalence (%) | 0.11 | 0.06 | 0.14 |
| Median age at first event (years) | 77.08 | 76.92 | 77.17 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 496
- Matched controls
- 4960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
4503599627370496.0
307.7
493
*
B01AA03
ATC
warfarin; systemic
10.7
143.3
370
1066
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
23.1
105.6
80
41
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
8.0
91.3
153
263
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.3
72.7
318
1256
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
9.1
67.2
91
120
207
Kela drug reimbursment
Chronic arrhythmias
3.3
33.3
182
747
AA1AD
NOMESCO Finland
CT of head and brain
3.0
31.7
234
1134
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
8.1
31.5
44
59
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
9.9
30.4
36
39
K78
ICPC
Atrial fibrillation/flutter
3.8
30.1
109
342
R04.0
ICD-10 Finland
Epistaxis
3.9
26.8
90
267
B01AB05
ATC
enoxaparin; parenteral
2.7
25.2
225
1171
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
24.0
150
648
TFP20
NOMESCO Finland
Cardiodefibrillation
3.6
23.9
89
282
C03CA01
ATC
furosemide; systemic
2.6
22.8
296
1816
C01AA05
ATC
digoxin; systemic
3.1
22.1
112
428
W19
ICD-10 Finland
Unspecified fall
3.2
20.6
93
331
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
19.9
234
1347
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
19.3
161
792
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.8
19.2
64
187
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
5.5
18.4
37
72
C07AB07
ATC
bisoprolol; oral
2.4
18.3
339
2344
I50.9
ICD-10 Finland
Heart failure, unspecified
2.4
18.0
171
888
C01BD01
ATC
amiodarone; systemic
5.4
17.7
36
71
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
3.6
16.4
58
176
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.4
16.2
151
772
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
15.8
166
892
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
14.5
125
615
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
15.3
13.7
22
15
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
12.9
178
1051
WX892
NOMESCO Finland
Monitored bed care
3.0
12.7
62
229
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
5.4
12.6
25
48
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
9.3
12.4
25
28
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
10.9
12.4
23
22
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.2
12.2
130
693
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.0
12.0
200
1257
D68.8
ICD-10 Finland
Other specified coagulation defects
47.9
11.9
14
*
D62
ICD-10 Finland
Acute posthaemorrhagic anaemia
10.9
11.9
22
21
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
11.7
271
1900
K99
ICPC
Cardiovascular disease other
4.6
11.6
28
64
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
5.9
11.6
21
37
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
11.5
133
731
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.9
11.3
34
92
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
17.6
11.3
17
10
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
11.3
87
404
I61.6
ICD-10 Finland
Intracerebral haemorrhage, multiple localized
25.7
11.2
15
6
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
4.8
11.1
25
54
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.0
10.7
48
169
S06.3
ICD-10 Finland
Focal brain injury
8.8
10.6
22
26
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
8.5
10.4
22
27
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
9.9
10.3
20
21
X59
ICD-10 Finland
Exposure to unspecified factor
2.2
10.2
100
513
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.9
9.7
48
178
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
3.2
9.7
40
134
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
9.5
103
548
ZXD05
NOMESCO Finland
Urgent procedure
1.9
9.4
171
1089
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
4.2
9.4
25
62
N30.9
ICD-10 Finland
Cystitis, unspecified
2.8
8.8
44
164
I48.2
ICD-10 Finland
Chronic atrial fibrillation
2.8
8.8
45
170
S06.0
ICD-10 Finland
Concussion
2.3
8.6
69
324
I50.0
ICD-10 Finland
Congestive heart failure
2.2
8.6
82
415
D69.3
ICD-10 Finland
Idiopathic thrombocytopenic purpura
+∞
8.4
8
*
K92.2
ICD-10 Finland
Gastrointestinal haemorrhage, unspecified
3.4
8.3
30
92
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
3.8
8.3
25
68
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
17.5
8.1
12
7
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
17.5
8.1
12
7
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.5
8.1
55
240
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
1.8
8.0
158
1023
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.3
8.0
64
301
M10.9
ICD-10 Finland
Gout, unspecified
2.4
7.8
57
257
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.9
7.8
38
140
K90
ICPC
Stroke/cerebrovascular accident
3.3
7.8
29
91
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
4.6
7.7
18
40
I48.1
ICD-10 Finland
Persistent atrial fibrillation
2.9
7.7
36
130
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.3
7.7
60
279
N17.9
ICD-10 Finland
Acute renal failure, unspecified
2.9
7.6
37
136
NB1AA
NOMESCO Finland
Shoulder X-ray examination without contrast
2.6
7.6
45
184
C01BC04
ATC
flecainide; systemic
3.1
7.2
30
101
M04AA01
ATC
allopurinol; systemic
1.9
7.2
103
601
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.2
7.2
66
328
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.2
7.1
64
315
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.9
7.0
103
607
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.8
6.9
34
126
I50
ICD-10 Finland
Heart failure
2.7
6.9
36
138
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.5
6.8
23
68
PA2AD
NOMESCO Finland
CT angiography of brain
17.0
6.8
10
6
WX730
NOMESCO Finland
Conventional respirator
5.6
6.7
18
33
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.0
6.7
77
417
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.9
6.6
94
547
SPAT1263
SPAT
Sampling
1.6
6.6
204
1480
TKC20
NOMESCO Finland
Catheterisation of bladder
2.2
6.5
59
292
201
Kela drug reimbursment
Chronic cardiac insufficiency
2.3
6.5
50
231
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
2.5
6.5
40
167
B01AF02
ATC
apixaban; oral
1.9
6.5
89
512
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
70.7
6.4
7
*
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
3.7
6.4
20
56
I25.5
ICD-10 Finland
Ischaemic cardiomyopathy
3.4
6.3
22
66
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
11.2
6.3
11
10
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.7
6.3
139
920
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
2.5
6.3
38
157
X59.9
ICD-10 Finland
Exposure to unspecified factor causing other and unspecified injury
+∞
6.3
6
*
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
6.3
6
*
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
+∞
6.3
6
*
126
Kela drug reimbursment
Chronic coagulation defects
+∞
6.3
6
*
C07AB02
ATC
metoprolol; systemic
1.7
6.3
144
964
R06
ICPC
Nose bleed/epistaxis
3.8
6.3
19
52
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.8
6.2
30
110
212
Kela drug reimbursment
Gout
3.5
6.2
21
62
AN1
HP
Coronary angiography
1.9
6.2
88
512
379
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the long-term prevention of recurrent deep veinthrombosis and pulmonary embolism
3.7
6.1
19
53
WX872
NOMESCO Finland
Intensive care
2.6
6.1
35
141
D64.9
ICD-10 Finland
Anaemia, unspecified
1.9
6.1
83
476
E000003, ,
ATC
3.1
6.0
25
84
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
183
668
3.76
41.67
4.7
1.8
35.27
29.91
s
8.30
178
643
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
73
158
5.25
32.68
4.0
2.4
0.31
0.33
u/ml
0.22
50
86
349
2166
3.06
29.00
53.3
19.8
1.89
1.39
inr
8.70
110
603
104
369
3.30
23.37
12.0
6.8
12.43
12.07
mmol/l
0.15
99
347
147
656
2.76
21.82
4.5
3.0
0.81
0.82
mmol/l
0.22
132
608
225
1251
2.46
20.99
3.3
2.0
229.86
310.04
u/l
0.56
215
1174
128
558
2.74
19.66
6.9
5.2
1.02
1.03
mmol/l
0.18
120
507
165
941
2.13
13.17
3.5
2.6
—
—
—
0
0
128
665
2.25
12.88
3.7
2.4
2.20
2.26
g/l
0.45
115
609
133
722
2.15
11.89
3.8
2.4
10.39
11.69
umol/l
1.52
121
662
60
229
2.84
11.55
1.7
1.5
1.58
1.64
g/l
0.20
53
206
120
638
2.16
11.25
4.0
2.5
19.10
20.88
%
0.86
106
547
187
1173
1.95
11.11
3.2
2.2
3.72
3.23
mg/l
1.20
157
994
108
574
2.13
10.03
2.2
2.1
1.83
1.74
%
0.43
83
509
268
1944
1.82
9.72
9.5
5.9
1.19
1.21
mmol/l
5.56
245
1745
246
1745
1.81
9.55
3.6
2.8
—
—
—
0
0
103
548
2.11
9.51
10.7
7.2
1.01
1.31
mmol/l
0.27
87
422
103
551
2.10
9.36
10.7
7.1
5.02
5.08
kpa
0.19
97
526
38
127
3.16
9.21
3.4
3.0
0.71
0.94
nmol/l
1.86
29
98
57
238
2.58
9.20
12.1
9.1
24.08
24.53
mmol/l
0.36
52
229
102
552
2.07
8.96
10.8
7.1
11.72
11.32
kpa
0.28
95
527
80
396
2.22
8.83
1.8
2.8
64.33
65.83
g/l
0.83
74
350
222
1553
1.78
8.83
6.0
3.1
2835.40
2135.25
ng/l
1.47
190
1347
19
25
7.86
8.72
1.2
1.1
—
—
—
0
0
135
815
1.90
8.65
2.2
1.8
—
—
—
0
0
251
1829
1.75
8.58
6.2
4.4
32.37
34.39
g/l
6.06
232
1687
26
72
3.76
8.39
1.1
1.1
—
—
—
0
0
279
2104
1.75
8.37
11.0
6.5
1.19
1.21
mmol/l
5.10
232
1762
306
2387
1.74
7.96
8.0
4.9
7.20
6.90
mmol/l
1.40
296
2255
82
428
2.10
7.88
5.8
3.0
420.03
279.21
ng/l
1.73
75
395
238
1749
1.69
7.58
6.4
4.2
40.13
62.97
ng/l
0.67
202
1373
272
2072
1.69
7.56
8.0
5.7
13.54
12.02
umol/l
1.45
259
1950
80
425
2.05
7.32
3.1
2.5
6.83
6.10
ug/l
0.21
69
363
230
1689
1.67
7.25
7.6
5.5
21.20
24.92
%
5.63
210
1566
39
154
2.66
7.04
2.5
3.4
33.51
35.60
mg/l
0.15
31
124
225
1657
1.66
6.92
7.2
5.3
64.04
59.47
%
6.44
208
1539
12
11
11.14
6.83
1.3
1.2
—
—
—
0
0
38
152
2.62
6.69
2.6
3.4
62.30
107.50
mg/l
0.51
32
121
122
773
1.77
6.48
4.9
1.7
2.62
1.48
mg/l
1.43
97
606
149
999
1.70
6.47
3.5
2.9
5224.68
8201.11
umol/l
0.25
124
847
14
19
7.55
6.45
2.6
1.8
—
—
—
0
0
66
343
2.07
6.39
2.1
1.7
—
—
—
0
0
147
987
1.70
6.33
2.1
1.8
1168.87
1175.89
nmol/l
0.02
105
736
16
29
5.66
6.04
1.6
1.1
7.17
4.73
u/ml
—
6
11
26
94
2.86
5.55
1.5
1.5
298.21
266.97
ug/g
0.34
14
51
37
162
2.39
5.43
2.0
2.3
0.44
1.12
g/l
0.78
31
137
171
1235
1.59
5.37
2.6
2.4
57.36
126.46
u/l
0.54
159
1144
54
285
2.00
5.02
7.2
3.9
3.02
2.10
mmol/l
0.56
39
207
41
195
2.20
4.98
2.1
1.8
—
—
—
0
0
91
574
1.72
4.82
2.1
1.7
—
—
—
0
0
39
187
2.18
4.66
1.9
2.1
—
—
—
0
0
187
1422
1.51
4.49
3.5
3.1
2.31
2.34
mmol/l
1.91
154
1216
27
112
2.49
4.47
1.4
1.3
—
—
—
0
0
27
112
2.49
4.47
1.4
1.3
—
—
—
0
0
254
2057
1.48
4.45
3.8
3.0
63.23
55.74
u/l
0.77
232
1861
37
178
2.17
4.39
7.5
4.5
25.49
25.03
mmol/l
0.25
31
168
34
158
2.24
4.39
1.5
1.2
—
—
—
0
0
151
1103
1.53
4.36
4.1
3.0
42.26
37.14
u/l
0.32
135
1053
199
1541
1.49
4.34
4.3
2.8
171.90
158.73
ug/l
0.26
173
1382
58
331
1.85
4.29
4.6
4.0
120.81
93.58
ng/l
1.34
48
287
56
316
1.87
4.29
2.0
1.6
—
—
—
0
0
88
573
1.65
4.12
2.1
1.7
—
—
—
0
0
74
460
1.72
4.12
5.1
3.8
—
—
—
0
0
54
309
1.84
3.97
7.2
3.8
5.45
5.14
kpa
1.10
47
296
17
59
2.95
3.93
2.1
1.8
89.15
89.12
%
0.01
17
59
41
216
1.98
3.86
4.8
4.3
24.58
23.94
mmol/l
0.48
41
210
36
181
2.07
3.84
2.0
1.6
—
—
—
0
0
54
314
1.81
3.78
1.8
1.7
387.87
391.72
nmol/l
0.04
47
278
38
198
2.00
3.69
2.1
1.8
1.91
3.11
ug/l
0.29
29
168
22
92
2.46
3.61
3.8
2.1
14.59
15.62
%
—
8
42
251
2083
1.42
3.58
9.7
8.1
4.92
4.40
e9/l
2.17
218
1812
69
442
1.65
3.44
5.0
3.8
2.05
1.93
mmol/l
0.07
58
354
49
285
1.80
3.44
1.5
1.5
—
—
—
0
0
120
875
1.49
3.40
6.0
3.9
227.06
284.00
ng/l
0.23
110
760
15
53
2.89
3.38
1.3
1.3
—
—
—
0
0
69
448
1.63
3.26
2.6
2.5
10.51
8.85
umol/l
0.28
63
395
52
313
1.74
3.26
9.9
6.8
24.76
24.26
mmol/l
0.32
47
299
25
117
2.20
3.22
2.1
1.4
—
—
—
0
0
13
40
3.31
3.16
1.1
1.8
—
—
—
0
0
29
146
2.05
3.12
3.4
2.8
3.63
4.25
pmol/l
2.48
24
130
18
74
2.49
3.08
1.7
1.6
—
—
—
0
0
16
62
2.63
3.07
1.5
1.6
—
—
—
0
0
16
62
2.63
3.07
1.5
1.6
—
—
—
0
0
128
966
1.44
3.01
3.4
2.7
6.35
4.40
e6/l
0.42
118
868
11
31
3.60
3.01
1.6
1.2
—
—
—
0
0
330
2920
1.39
2.96
11.4
7.2
84.54
80.85
u/l
0.71
309
2714
43
253
1.77
2.92
1.8
1.6
1.58
1.58
%
0.01
36
211
191
1559
1.37
2.82
4.9
3.6
—
—
—
0
0
12
39
3.13
2.79
1.1
1.8
—
—
—
0
0
12
39
3.13
2.79
1.1
1.8
—
—
—
0
0
12
39
3.13
2.79
1.1
1.8
—
—
—
0
0
21
98
2.19
2.74
3.1
2.0
120.15
127.90
g/l
0.38
13
69
153
1215
1.37
2.65
4.3
3.5
0.36
0.54
e6/l
0.91
130
956
166
1337
1.36
2.63
4.5
3.7
85.63
118.18
e6/l
0.18
142
1067
12
44
2.77
2.56
2.3
2.6
—
—
—
0
0
10
31
3.27
2.53
1.7
1.2
—
—
—
0
0
19
89
2.18
2.48
1.9
1.5
—
—
—
0
0
8
21
3.85
2.47
1.0
1.9
—
—
—
0
0
8
21
3.85
2.47
1.0
1.9
—
—
—
0
0
11
38
2.94
2.43
1.1
1.8
—
—
—
0
0
11
38
2.94
2.43
1.0
1.1
—
—
—
0
0
15
64
2.39
2.41
1.1
1.3
68996.00
28763.14
e6/l
—
10
44
7
17
4.16
2.36
1.0
2.0
—
—
—
0
0
7
17
4.16
2.36
1.0
2.0
—
—
—
0
0
54
359
1.57
2.35
2.7
2.4
27.49
34.21
u/l
1.21
49
294
20
98
2.08
2.35
1.6
1.5
—
—
—
0
0
7
18
3.93
2.26
1.3
1.9
—
—
—
0
0
19
95
2.04
2.13
1.6
1.5
—
—
—
0
0
14
64
2.22
1.96
4.2
3.2
63.86
61.73
%
0.29
14
64
66
890
0.70
1.94
1.8
1.6
1.32
1.31
mmol/l
0.06
58
718
6
16
3.78
1.94
1.0
1.2
—
—
—
0
0
6
16
3.78
1.94
1.0
1.1
—
—
—
0
0
13
59
2.24
1.85
2.0
1.4
—
—
—
0
0
21
117
1.83
1.77
1.3
1.5
—
—
—
0
0
110
882
1.32
1.74
3.4
3.0
2.46
2.46
mmol/l
0.12
89
764
13
61
2.16
1.73
4.1
2.9
5.45
4.90
e9/l
0.27
13
61
21
118
1.81
1.73
1.3
1.2
—
—
—
0
0
7
24
2.94
1.73
1.9
2.4
—
—
—
0
0
205
1786
1.25
1.67
2.6
2.1
88.01
92.82
pmol/l
0.93
114
919
10
42
2.41
1.62
1.1
1.1
—
—
—
0
0
298
2713
1.25
1.61
5.9
4.1
21.55
15.13
mm/h
4.67
265
2445
65
489
1.38
1.56
1.2
1.3
49.66
38.30
iu/ml
0.25
20
164
6
21
2.88
1.51
1.7
1.1
—
—
—
0
0
6
21
2.88
1.51
1.7
1.1
—
—
—
0
0
20
117
1.74
1.47
1.4
1.2
—
—
—
0
0
7
28
2.52
1.45
2.3
2.5
—
—
—
0
0
5
16
3.15
1.44
1.4
2.2
—
—
—
0
0
88
703
1.31
1.43
3.9
3.5
2.72
1.80
e6/l
0.34
52
424
380
3578
1.27
1.42
35.5
17.9
30.98
27.79
mg/l
1.27
352
2951
5
17
2.96
1.36
1.2
1.7
1.40
4.17
u/field
—
5
12
48
354
1.39
1.32
5.9
3.3
1.20
1.22
mmol/l
2.02
41
307
9
43
2.11
1.31
1.2
1.3
—
—
—
0
0
15
84
1.81
1.28
1.8
1.3
—
—
—
0
0
63
491
1.32
1.23
16.0
8.7
—
—
—
0
0
8
37
2.18
1.22
1.4
1.5
—
250.00
—
0
6
6
26
2.32
1.19
2.3
1.3
—
—
—
0
0
5
21
2.39
1.09
2.2
1.3
—
—
—
0
0
8
41
1.97
1.09
2.0
1.4
—
—
—
0
0
8
41
1.97
1.09
2.0
1.4
—
—
—
0
0
11
59
1.88
1.08
2.1
1.4
—
—
—
0
0
9
46
1.97
1.04
2.2
1.3
—
—
—
0
0
88
734
1.24
1.03
3.3
3.2
2.21
1.11
e6/l
0.36
51
452
17
259
0.64
0.99
1.9
2.0
7.72
12.46
nmol/l
2.43
12
222
9
50
1.81
0.97
2.0
1.3
—
—
—
0
0
11
62
1.79
0.95
1.6
1.4
—
—
—
0
0
16
101
1.60
0.94
1.7
1.6
0.11
0.10
iu/ml
—
6
26
129
1129
1.19
0.94
1.9
1.6
18.92
20.24
nmol/l
0.50
108
944
12
70
1.73
0.93
1.9
1.4
—
—
—
0
0
9
52
1.74
0.93
2.0
1.3
—
—
—
0
0
9
52
1.74
0.93
2.0
1.3
—
—
—
0
0
9
52
1.74
0.93
2.0
1.3
—
—
—
0
0
9
52
1.74
0.93
2.0
1.3
—
—
—
0
0
10
55
1.84
0.92
1.7
1.4
—
—
—
0
0
14
87
1.63
0.88
2.9
1.6
—
—
—
0
0
276
2581
1.16
0.86
4.0
3.6
15.18
15.11
pmol/l
0.14
237
2257
316
3323
0.86
0.82
4.9
4.6
1.33
1.42
mmol/l
3.53
265
2955
6
33
1.83
0.79
1.0
1.2
—
—
—
0
0
0
26
0.00
0.78
0.0
3.3
—
—
—
0
0
37
289
1.30
0.76
2.8
3.2
55.64
54.33
ml/min/173m2
0.10
25
119
9
53
1.71
0.75
2.0
1.3
—
—
—
0
0
7
40
1.76
0.71
1.0
1.3
—
—
—
0
0
166
1515
1.14
0.71
2.8
2.2
76.12
78.68
nmol/l
0.60
137
1311
16
110
1.47
0.69
2.1
1.3
—
—
—
0
0
12
77
1.57
0.69
1.6
1.6
—
—
—
0
0
7
42
1.68
0.68
1.0
1.0
—
—
—
0
0
19
137
1.40
0.65
1.1
1.1
180.17
176.55
iu/ml
—
6
41
20
146
1.39
0.64
1.4
1.3
—
—
—
0
0
333
3465
0.88
0.64
5.1
5.3
2.27
2.50
mmol/l
4.94
282
3089
109
974
1.15
0.63
1.8
1.8
410.75
7215625.97
pmol/l
0.50
77
790
53
447
1.21
0.60
1.1
1.3
23.10
13.55
u/ml
0.23
13
156
0
21
0.00
0.60
0.0
1.3
—
—
—
0
0
56
476
1.20
0.59
4.4
4.8
32.18
32.59
%
0.11
34
307
283
2964
0.89
0.58
40.4
21.2
15.46
15.36
%
0.14
275
2913
388
3764
1.14
0.57
40.5
21.4
139.05
139.52
mmol/l
2.37
368
3653
8
54
1.49
0.57
1.4
1.4
—
—
—
0
0
56
479
1.19
0.56
3.4
3.9
3.14
33.74
ug/l
1.20
45
408
6
37
1.63
0.55
1.3
1.2
—
—
—
0
0
324
3363
0.89
0.55
4.7
4.6
4.06
4.35
mmol/l
5.32
276
3021
388
3768
1.14
0.55
40.6
21.6
3.99
4.03
mmol/l
1.47
368
3658
9
60
1.51
0.54
1.2
1.1
—
—
—
0
0
11
75
1.48
0.51
1.1
1.1
—
17.17
—
0
6
310
3207
0.91
0.44
4.5
4.2
1.27
1.24
mmol/l
0.35
260
2821
7
51
1.38
0.44
1.6
1.6
—
—
—
0
0
15
113
1.34
0.43
1.7
1.3
—
—
—
0
0
322
3323
0.91
0.43
6.7
6.6
41.45
41.39
mmol/mol
0.03
270
3015
113
1042
1.11
0.41
6.1
4.6
0.00
0.00
estimate
-0.00
40
325
0
17
0.00
0.40
0.0
1.1
—
1.06
—
0
10
76
839
0.89
0.40
7.1
5.0
1.02
1.02
kg/l
0.02
14
131
5
35
1.43
0.39
1.0
1.1
179.00
231.73
pmol/l
—
5
30
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
334
3434
0.92
0.38
5.0
5.0
6.20
6.14
mmol/l
0.25
274
3042
5
36
1.39
0.38
1.8
1.4
—
—
—
0
0
175
1844
0.92
0.36
7.6
5.9
0.00
0.00
estimate
-0.00
44
340
6
43
1.40
0.35
1.7
2.5
—
—
—
0
0
69
627
1.12
0.34
1.1
1.2
0.82
1.31
u/ml
0.98
13
149
183
1743
1.08
0.33
4.6
5.5
5.20
5.36
ug/l
0.02
158
1519
177
1856
0.93
0.32
5.8
4.4
0.00
0.00
estimate
-0.00
47
379
392
3852
1.08
0.28
48.3
25.9
232.09
236.68
e9/l
0.59
371
3739
392
3853
1.08
0.28
49.5
26.0
37.83
39.08
%
3.14
355
3534
137
1442
0.93
0.28
6.5
4.7
—
—
—
0
0
392
3854
1.08
0.27
48.3
25.9
4.20
4.37
e12/l
6.07
370
3727
179
1864
0.94
0.26
5.9
4.4
0.00
0.00
estimate
-0.00
43
335
392
3856
1.08
0.26
48.8
26.0
125.65
132.05
g/l
10.18
379
3769
133
1397
0.93
0.25
4.0
4.7
23.13
21.65
%
0.52
65
728
22
255
0.86
0.25
1.8
1.3
—
—
—
0
0
9
75
1.20
0.25
1.2
1.3
—
—
—
0
0
324
3308
0.94
0.24
31.5
17.0
67.13
71.16
ml/min/173m2
2.12
287
2772
20
172
1.17
0.22
2.1
2.9
—
—
—
0
0
5
42
1.19
0.21
2.2
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
5
43
1.16
0.21
1.8
1.4
62.80
68.88
%
—
5
33
5
43
1.16
0.21
3.6
2.5
9.88
7.80
nmol/l
—
5
43
6
48
1.25
0.20
2.7
4.4
—
—
—
0
0
6
53
1.13
0.18
1.0
1.0
—
—
—
0
0
328
3226
1.05
0.18
5.0
4.4
2.08
2.04
mu/l
0.20
278
2845
125
1206
1.05
0.15
3.5
3.2
6.17
7.09
mmol/l
2.11
92
985
6
78
0.77
0.15
1.5
1.7
—
—
—
0
0
131
1269
1.04
0.14
4.2
3.8
26.60
10.16
mg/mmol
1.43
89
827
97
999
0.96
0.10
3.1
3.2
0.72
0.82
ug/l
0.55
67
702
15
136
1.11
0.08
1.0
1.0
—
—
—
0
0
5
60
0.83
0.08
1.2
1.4
162.80
301.66
u/l
—
5
60
32
336
0.95
0.07
1.2
1.3
—
—
—
0
0
374
3717
1.03
0.06
15.7
10.8
25.07
24.21
u/l
0.49
347
3552
17
180
0.94
0.04
4.4
3.1
290.50
1114.15
u/ml
0.51
12
153
11
119
0.92
0.04
2.1
1.8
—
—
—
0
0
167
1656
1.01
0.03
2.8
2.4
—
—
—
0
0
11
107
1.03
0.00
1.8
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.2
—
97.08
—
0
6
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
1.23
—
0
9
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
44.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
77.67
—
0
6
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.7
—
13.24
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
42.40
—
0
5
0
8
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
10.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
6
63
0.95
-0.00
1.2
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
59
0.85
-0.00
1.0
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
-0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_HAEMORRHAGCIRGUANTICO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGCIRGUANTICO | 2.704 [1.88, 3.89] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 431 females with D3_HAEMORRHAGCIRGUANTICO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGCIRGUANTICO | 2.812 [1.94, 4.07] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 470 males with D3_HAEMORRHAGCIRGUANTICO died.
Mortality risk
Mortality risk for people of age
years, who have D3_HAEMORRHAGCIRGUANTICO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.516% |
| 5 | 1.195% | 2.941% |
| 10 | 3.153% | 7.068% |
| 15 | 5.678% | 12.913% |
| 20 | 10.172% | 21.439% |
Relationships between endpoints
↥Index endpoint: D3_HAEMORRHAGCIRGUANTICO – Haemorrhagic disorder due to circulating anticoagulants
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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