No definition available.
Haemorrhagic disorder due to circulating anticoagulants
EFO MESH Endpoint Browser PheWeb
D3_HAEMORRHAGCIRGUANTICO
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
406 |
4. Check minimum number of eventsNone |
406 |
5. Include endpointsNone |
406 |
6. Filter based on genotype QC (FinnGen only) |
406 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Perturbatio haemorrhagica ex anticoagulantibus circulantibus
Similar endpoints
↥List of similar endpoints to
Haemorrhagic disorder due to circulating anticoagulants
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Bleeding
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4217 | 1891 | 2271 |
| Only index persons | 3038 | 1409 | 1629 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.05 | 0.06 |
| Only index persons | 0.06 | 0.05 | 0.06 |
| Median age at first event (years) | |||
| Whole population | 78.36 | 81.68 | 75.74 |
| Only index persons | 79.55 | 82.39 | 77.09 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 406 | 146 | 260 |
| Unadjusted period prevalence (%) | 0.09 | 0.05 | 0.11 |
| Median age at first event (years) | 75.42 | 73.94 | 76.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 354
- Matched controls
- 3538
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.3
ICD-10 Finland
Haemorrhagic disorder due to circulating anticoagulants
+∞
323.0
351
*
B01AA03
ATC
warfarin; systemic
14.8
108.4
284
759
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.5
49.2
228
876
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
24.8
38.9
55
26
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
9.0
37.6
85
120
C03CA01
ATC
furosemide; systemic
3.1
22.8
210
1133
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
7.6
21.6
52
78
B01AB05
ATC
enoxaparin; parenteral
3.0
19.5
159
764
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
18.1
106
402
R04.0
ICD-10 Finland
Epistaxis
4.8
17.6
62
150
R58
ICD-10 Finland
Haemorrhage, not elsewhere classified
14.4
16.8
28
21
C07AB07
ATC
bisoprolol; oral
2.6
16.6
237
1537
I50.9
ICD-10 Finland
Heart failure, unspecified
2.9
16.5
121
532
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
16.3
113
477
K78
ICPC
Atrial fibrillation/flutter
3.8
16.0
74
231
TFP20
NOMESCO Finland
Cardiodefibrillation
4.2
15.7
63
173
AA1AD
NOMESCO Finland
CT of head and brain
2.7
15.5
143
714
C01AA05
ATC
digoxin; systemic
3.1
13.6
83
317
207
Kela drug reimbursment
Chronic arrhythmias
2.7
13.4
107
485
W19
ICD-10 Finland
Unspecified fall
3.6
13.2
62
195
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
8.4
12.9
28
36
D68.8
ICD-10 Finland
Other specified coagulation defects
134.6
12.5
13
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
12.1
150
851
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
22.2
12.1
17
8
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
4.1
11.8
47
127
I25.1
ICD-10 Finland
Atherosclerotic heart disease
2.3
11.3
148
856
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
10.6
11.2
21
21
I50.0
ICD-10 Finland
Congestive heart failure
2.9
10.7
68
264
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
7.2
10.6
25
37
I26.9
ICD-10 Finland
Pulmonary embolism without mention of acute cor pulmonale
4.1
10.4
41
110
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
18.2
9.5
14
8
I61.6
ICD-10 Finland
Intracerebral haemorrhage, multiple localized
102.7
9.5
10
*
C01BD01
ATC
amiodarone; systemic
5.0
9.3
29
62
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
4.6
8.9
30
70
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
9.3
8.1
16
18
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
3.9
8.0
32
88
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.0
7.9
114
666
WX730
NOMESCO Finland
Conventional respirator
8.3
7.7
16
20
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
7.7
178
1236
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.1
7.5
96
529
C03DA01
ATC
spironolactone; oral
2.4
7.3
63
290
B01AB10
ATC
tinzaparin; parenteral
3.4
7.3
34
107
UJF32
NOMESCO Finland
Coloscopy
2.0
7.1
110
655
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.8
7.1
45
174
S06.0
ICD-10 Finland
Concussion
2.7
7.1
49
200
S06.3
ICD-10 Finland
Focal brain injury
7.2
7.1
16
23
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
6.9
58
261
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
3.4
6.9
32
100
I26.0
ICD-10 Finland
Pulmonary embolism with mention of acute cor pulmonale
5.9
6.9
18
32
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.9
6.9
123
774
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
40.9
6.8
8
*
I61.4
ICD-10 Finland
Intracerebral haemorrhage in cerebellum
17.1
6.8
10
6
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.5
6.8
30
91
TFC25
NOMESCO Finland
Transseptal catheterisation of left atrium or ventricle
12.6
6.6
11
9
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.7
6.6
45
181
S97
ICPC
Chronic ulcer skin
3.3
6.6
32
104
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
3.2
6.4
32
106
I50
ICD-10 Finland
Heart failure
3.5
6.4
28
84
XF400
NOMESCO Finland
ECG with 12 standard connections
2.1
6.3
80
439
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
6.3
6
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
2.9
6.2
36
133
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
12.8
6.1
10
8
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
12.8
6.1
10
8
I74.3
ICD-10 Finland
Embolism and thrombosis of arteries of lower extremities
8.8
6.1
12
14
WX892
NOMESCO Finland
Monitored bed care
2.8
6.1
39
152
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
3.7
6.0
25
72
H02AB06
ATC
prednisolone; systemic
1.7
6.0
169
1216
EBA10
NOMESCO Finland
Surgical removal of tooth
3.2
6.0
30
100
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
147
550
3.62
32.05
52.2
29.1
2.1
1.4
inr
3.77
14
61
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
60
111
6.17
32.05
3.3
2.2
0.3
0.3
u/ml
0.34
41
63
114
522
2.65
15.96
4.8
2.9
0.8
0.8
mmol/l
0.22
103
480
98
428
2.70
14.98
5.6
5.1
1.0
1.0
mmol/l
0.42
92
387
169
993
2.20
13.06
3.3
2.0
223.8
347.1
u/l
0.76
161
933
16
20
8.29
11.96
1.1
1.1
—
—
—
0
0
98
513
2.20
9.68
3.2
2.4
2.2
2.2
g/l
0.32
86
470
93
488
2.17
9.08
3.7
2.5
18.6
21.1
%
1.17
82
426
102
559
2.10
8.89
3.4
2.4
10.1
11.9
umol/l
2.23
92
512
125
748
1.97
8.50
3.4
2.6
—
—
—
0
0
145
925
1.88
8.07
3.2
2.1
3.5
3.2
mg/l
0.70
122
781
44
176
2.68
7.80
1.5
1.6
1.8
1.7
g/l
0.37
39
160
13
21
6.36
7.76
1.6
1.1
8.4
5.1
u/ml
—
5
10
67
333
2.21
7.40
5.4
3.0
452.5
282.5
ng/l
1.73
61
304
210
1530
1.77
7.37
9.0
5.9
1.2
1.2
mmol/l
4.68
192
1360
11
8
14.09
6.92
1.4
1.3
—
—
—
0
0
29
99
3.08
6.84
2.9
2.8
0.7
1.0
nmol/l
1.59
22
77
43
185
2.48
6.58
9.4
10.1
24.2
24.6
mmol/l
0.27
38
168
79
444
1.97
6.27
9.4
7.6
5.0
5.1
kpa
0.21
73
422
79
445
1.96
6.22
9.4
7.6
10.9
11.3
kpa
0.33
72
424
78
440
1.96
6.11
9.5
7.7
1.1
1.3
mmol/l
0.13
63
332
19
53
3.71
6.11
1.1
1.1
—
—
—
0
0
121
793
1.75
5.86
3.4
2.8
404.8
6486.7
umol/l
3.30
100
667
63
336
2.04
5.77
3.0
2.5
6.2
6.5
ug/l
0.06
53
291
214
1658
1.61
5.31
9.9
6.5
1.2
1.2
mmol/l
4.55
172
1370
23
80
2.99
5.28
1.4
1.3
—
—
—
0
0
23
80
2.99
5.28
1.4
1.3
—
—
—
0
0
16
44
3.74
5.25
6.8
6.3
10.9
12.3
mg/l
0.51
16
39
64
362
1.91
4.94
5.2
3.9
—
—
—
0
0
183
1382
1.59
4.94
5.1
4.4
—
—
—
0
0
168
1247
1.59
4.86
5.7
3.2
3003.5
2140.1
ng/l
1.58
140
1075
190
1460
1.57
4.69
6.2
4.4
32.2
34.3
g/l
5.08
174
1346
182
1392
1.56
4.54
6.6
4.2
42.1
46.1
ng/l
0.24
153
1086
116
798
1.64
4.54
2.0
1.8
1288.9
1176.1
nmol/l
0.41
81
599
96
638
1.66
4.27
2.3
1.8
—
—
—
0
0
209
1666
1.52
4.22
7.9
5.6
13.2
11.9
umol/l
1.11
198
1562
15
47
3.28
4.09
2.1
2.0
89.6
89.1
%
0.13
15
47
28
124
2.35
4.07
1.9
2.5
0.4
0.5
g/l
0.10
23
106
93
623
1.64
4.00
4.8
1.7
1.9
1.5
mg/l
0.41
74
490
48
266
1.91
3.94
2.1
1.6
—
—
—
0
0
26
117
2.31
3.66
3.0
3.0
36.9
33.0
mg/l
0.25
21
94
230
1910
1.47
3.57
7.5
5.0
7.2
6.9
mmol/l
0.65
220
1795
142
1108
1.43
2.91
3.9
3.1
2.3
2.3
mmol/l
1.90
116
955
28
144
2.01
2.88
1.9
2.1
—
—
—
0
0
28
144
2.01
2.88
1.9
2.1
7.9
7.5
g/l
0.40
22
109
28
144
2.01
2.88
1.9
2.1
4.4
3.7
g/l
1.56
22
107
39
225
1.81
2.86
6.8
3.7
3.1
2.2
mmol/l
0.42
29
162
151
1198
1.41
2.80
3.9
2.7
165.9
163.6
ug/l
0.04
129
1068
27
139
2.01
2.77
1.9
2.2
4.0
3.2
g/l
1.85
22
108
45
695
0.60
2.64
1.8
1.6
1.4
1.4
mmol/l
0.16
40
557
17
74
2.35
2.61
4.2
2.2
15.4
15.4
%
—
5
34
24
121
2.05
2.61
1.5
1.2
—
—
—
0
0
128
997
1.41
2.60
2.8
2.4
57.5
57.4
u/l
0.00
117
919
65
447
1.54
2.47
2.2
1.7
—
—
—
0
0
248
2771
0.73
2.41
4.8
5.2
2.3
2.5
mmol/l
3.74
206
2465
19
91
2.14
2.37
1.4
1.4
—
—
—
0
0
41
256
1.67
2.32
3.6
3.7
126.0
89.9
ng/l
1.41
33
225
41
258
1.66
2.26
10.0
7.0
25.3
24.1
mmol/l
0.98
35
240
9
29
3.15
2.24
1.1
1.1
—
—
—
0
0
237
2652
0.74
2.21
4.7
4.6
1.3
1.4
mmol/l
2.10
195
2351
54
368
1.54
2.15
2.9
2.6
10.4
8.4
umol/l
0.28
48
324
27
153
1.82
2.14
2.3
1.8
—
—
—
0
0
241
2683
0.75
2.11
4.5
4.6
4.1
4.3
mmol/l
3.52
203
2407
37
231
1.66
2.11
1.5
1.5
—
—
—
0
0
113
890
1.37
2.11
4.5
2.9
33.2
34.3
u/l
0.14
99
851
27
154
1.81
2.10
1.9
1.7
2.2
3.8
ug/l
0.28
20
129
7
20
3.54
2.06
1.4
1.2
—
—
—
0
0
22
118
1.91
2.06
3.8
2.9
3.6
4.3
pmol/l
2.25
17
104
40
258
1.61
2.02
1.9
1.7
370.6
395.0
nmol/l
0.27
35
228
12
51
2.39
1.97
4.3
3.0
63.4
60.9
%
0.30
12
51
62
447
1.46
1.90
2.2
1.7
—
—
—
0
0
50
347
1.50
1.85
4.5
3.8
2.1
1.9
mmol/l
0.09
41
270
146
1219
1.31
1.81
5.0
3.5
—
—
—
0
0
191
1653
1.29
1.81
10.3
8.0
4.6
4.4
e9/l
0.78
169
1433
241
2659
0.77
1.80
6.4
6.6
42.0
41.6
mmol/mol
0.25
198
2419
24
139
1.77
1.80
2.0
1.7
—
—
—
0
0
249
2735
0.77
1.79
4.6
5.0
6.1
6.2
mmol/l
0.04
197
2418
110
1339
0.76
1.74
2.9
2.4
—
—
—
0
0
8
30
2.70
1.73
1.1
1.6
—
—
—
0
0
36
237
1.57
1.69
2.0
1.6
—
—
—
0
0
11
49
2.28
1.65
4.5
2.9
5.6
4.9
e9/l
0.30
11
49
6
20
3.03
1.58
1.5
1.2
—
—
—
0
0
12
57
2.14
1.56
2.0
1.4
—
—
—
0
0
87
692
1.33
1.50
6.6
3.9
214.2
288.1
ng/l
0.25
76
602
234
2565
0.79
1.50
4.2
4.2
1.3
1.2
mmol/l
0.35
194
2255
115
953
1.29
1.47
4.6
3.4
0.4
0.5
e6/l
0.57
98
738
10
45
2.25
1.47
2.3
1.3
—
—
—
0
0
7
28
2.53
1.46
1.4
1.1
51.0
40.7
u/l
—
7
18
5
16
3.15
1.44
2.2
3.6
—
—
—
0
0
5
16
3.15
1.44
1.2
1.7
1.4
4.5
u/field
—
5
11
187
1647
1.25
1.44
3.9
3.0
68.2
55.7
u/l
1.12
167
1491
40
281
1.47
1.43
5.4
3.3
1.2
1.2
mmol/l
2.25
33
243
7
29
2.44
1.40
1.1
1.7
—
—
—
0
0
31
208
1.53
1.37
1.9
1.7
1.5
1.6
%
0.10
26
175
6
23
2.63
1.37
2.3
2.6
—
—
—
0
0
13
68
1.94
1.35
2.1
1.4
—
—
—
0
0
8
34
2.38
1.30
2.6
2.7
—
—
—
0
0
9
44
2.07
1.27
1.6
1.2
—
—
—
0
0
14
77
1.85
1.27
1.9
1.4
—
—
—
0
0
244
2638
0.81
1.24
32.5
16.9
67.7
71.5
ml/min/173m2
1.54
218
2207
51
386
1.37
1.23
3.5
4.2
3.3
40.9
ug/l
1.17
42
326
85
694
1.28
1.22
3.8
3.1
2.5
2.5
mmol/l
0.02
68
605
15
86
1.77
1.20
2.1
1.3
—
—
—
0
0
20
125
1.63
1.20
8.9
3.4
4.0
4.0
mmol/l
0.06
20
115
5
20
2.52
1.15
2.8
1.2
—
—
—
0
0
14
80
1.78
1.14
3.8
2.0
117.6
130.6
g/l
—
9
56
7
31
2.28
1.11
1.1
1.6
—
—
—
0
0
7
31
2.28
1.11
1.1
1.6
—
—
—
0
0
7
31
2.28
1.11
1.1
1.6
—
—
—
0
0
7
32
2.21
1.08
1.0
1.0
—
—
—
0
0
13
75
1.76
1.04
1.9
1.4
—
—
—
0
0
32
232
1.41
1.01
3.3
3.3
120.7
125.4
g/l
0.55
32
227
7
35
2.02
1.00
1.1
1.3
—
—
—
0
0
7
36
1.96
0.97
2.6
1.3
—
—
—
0
0
6
27
2.24
0.94
1.3
1.1
—
—
—
0
0
13
79
1.67
0.89
1.8
1.6
0.1
0.1
iu/ml
—
5
21
15
95
1.60
0.88
1.4
1.2
—
—
—
0
0
8
45
1.79
0.84
2.4
1.4
—
—
—
0
0
132
1468
0.85
0.80
7.1
5.8
0.0
0.0
estimate
0.00
37
281
250
2348
1.17
0.80
11.5
7.0
85.7
80.2
u/l
0.95
233
2174
6
33
1.83
0.79
1.0
1.2
—
—
—
0
0
8
48
1.68
0.79
1.8
1.4
—
—
—
0
0
211
2262
0.86
0.79
43.0
21.6
14.8
14.0
%
11.18
203
2212
31
235
1.35
0.78
3.1
3.4
54.5
55.8
ml/min/173m2
0.10
22
101
48
388
1.27
0.78
18.3
8.5
—
—
—
0
0
9
54
1.68
0.75
2.1
1.4
—
—
—
0
0
285
2978
0.86
0.72
15.2
10.6
24.7
24.2
u/l
0.24
261
2845
9
57
1.59
0.71
1.2
1.2
—
—
—
0
0
14
93
1.52
0.70
1.2
1.5
—
—
—
0
0
13
85
1.55
0.69
1.8
1.3
—
—
—
0
0
7
42
1.68
0.68
1.9
1.4
—
—
—
0
0
5
27
1.86
0.68
1.0
1.1
—
—
—
0
0
14
94
1.51
0.67
1.4
1.2
—
—
—
0
0
5
28
1.80
0.66
1.0
1.1
179.0
236.0
pmol/l
—
5
21
135
1476
0.87
0.63
5.6
4.2
0.0
0.0
estimate
0.00
37
287
136
1485
0.87
0.62
5.6
4.4
0.0
0.0
estimate
0.00
36
272
17
122
1.41
0.61
2.2
2.9
—
—
—
0
0
0
21
0.00
0.60
0.0
3.3
—
—
—
0
0
6
37
1.63
0.55
1.7
1.4
—
—
—
0
0
244
2554
0.89
0.54
4.9
4.4
2.1
2.0
mu/l
0.17
202
2245
6
39
1.55
0.53
1.7
1.4
—
—
—
0
0
6
39
1.55
0.53
1.7
1.4
—
—
—
0
0
6
39
1.55
0.53
1.7
1.4
—
—
—
0
0
6
39
1.55
0.53
1.7
1.4
—
—
—
0
0
6
40
1.51
0.52
1.7
1.3
—
—
—
0
0
45
383
1.20
0.49
1.2
1.3
46.9
41.4
iu/ml
0.08
14
127
15
199
0.74
0.47
2.0
1.3
—
—
—
0
0
10
68
1.48
0.47
1.6
1.4
—
—
—
0
0
103
1125
0.89
0.46
3.7
4.7
23.4
21.7
%
0.48
47
578
62
549
1.15
0.44
4.3
3.3
1.7
1.8
e6/l
0.05
37
332
92
840
1.12
0.41
5.8
4.5
0.0
0.0
estimate
0.00
33
266
0
15
0.00
0.41
0.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.8
1.2
62.8
67.7
%
—
5
27
251
2417
1.10
0.40
37.1
19.2
36.6
38.3
%
1.51
141
1471
13
97
1.35
0.40
2.1
2.7
43.6
44.7
u/ml
0.02
13
90
108
1164
0.90
0.39
6.2
4.7
—
—
—
0
0
5
36
1.39
0.38
1.4
1.4
—
—
—
0
0
302
3098
0.90
0.38
48.7
25.6
125.1
132.3
g/l
10.25
289
3026
9
68
1.33
0.38
3.7
1.7
—
—
—
0
0
5
37
1.36
0.37
1.2
1.7
—
—
—
0
0
6
45
1.34
0.34
1.2
1.2
—
—
—
0
0
84
775
1.11
0.32
1.8
1.8
418.1
9135047.6
pmol/l
0.50
57
624
8
65
1.24
0.27
1.5
1.4
—
—
—
0
0
95
1006
0.93
0.24
4.2
4.1
24.5
10.3
mg/mmol
0.77
61
660
5
39
1.29
0.23
2.8
4.4
—
—
—
0
0
0
11
0.00
0.21
0.0
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
3.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
1.0
—
0
5
5
43
1.16
0.21
1.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
61
569
1.08
0.20
3.4
3.0
0.7
1.1
e6/l
1.25
35
348
83
877
0.93
0.20
1.7
1.7
18.7
20.4
nmol/l
0.47
69
733
7
59
1.19
0.18
1.1
1.1
—
20.5
—
0
5
38
349
1.10
0.18
1.2
1.3
23.1
15.2
u/ml
0.19
13
120
24
267
0.89
0.17
1.2
1.3
—
—
—
0
0
292
2875
1.06
0.17
36.1
17.7
32.0
28.0
mg/l
1.39
268
2368
14
120
1.17
0.16
1.4
1.2
—
—
—
0
0
298
3022
0.95
0.16
40.1
21.3
4.0
4.0
mmol/l
0.90
279
2933
137
1415
0.95
0.16
4.4
5.4
6.3
3.0
ug/l
0.61
114
1225
48
511
0.93
0.15
1.1
1.2
0.8
1.1
u/ml
—
8
123
298
3018
0.95
0.14
40.2
21.2
139.1
139.6
mmol/l
1.84
279
2929
221
2171
1.04
0.12
5.9
4.0
24.0
14.9
mm/h
5.89
192
1954
123
1196
1.04
0.11
2.5
2.2
77.3
78.7
nmol/l
0.21
100
1038
5
47
1.06
0.09
1.2
1.1
—
—
—
0
0
10
113
0.88
0.08
10.6
2.5
29.0
24.5
mmol/l
—
10
91
9
101
0.89
0.06
1.8
1.8
—
—
—
0
0
37
380
0.97
0.03
4.4
4.7
30.9
32.5
%
0.38
23
244
202
2033
0.99
0.03
4.2
3.6
15.3
15.1
pmol/l
0.31
170
1778
142
1412
1.01
0.01
2.5
2.1
86.0
91.7
pmol/l
0.95
79
738
15
148
1.01
0.00
3.9
3.3
347.1
1314.3
u/ml
—
10
123
11
111
0.99
0.00
1.0
1.0
—
—
—
0
0
80
804
0.99
0.00
3.0
3.1
0.8
0.8
ug/l
0.32
54
555
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
5
55
0.91
0.00
1.0
1.2
28.4
55.1
u/l
—
5
46
0
8
0.00
0.00
0.0
1.5
—
28.2
—
0
8
0
6
0.00
0.00
0.0
4.2
—
97.1
—
0
6
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
2.0
—
1.2
—
0
7
0
5
0.00
0.00
0.0
1.0
—
15.9
—
0
5
9
90
1.00
0.00
1.7
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
44.8
—
0
5
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
7
69
1.01
0.00
1.4
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
2.7
—
13.2
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint D3_HAEMORRHAGCIRGUANTICO and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGCIRGUANTICO | 2.704 [1.88, 3.89] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 199 out of 431 females with D3_HAEMORRHAGCIRGUANTICO died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_HAEMORRHAGCIRGUANTICO | 2.812 [1.94, 4.07] | < 0.001 |
| Birth year | 0.982 [0.97, 0.99] | < 0.001 |
During the follow-up period (1.1.1998 — 31.12.2019), 229 out of 470 males with D3_HAEMORRHAGCIRGUANTICO died.
Mortality risk
Mortality risk for people of age
years, who have D3_HAEMORRHAGCIRGUANTICO.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.18% | 0.516% |
| 5 | 1.195% | 2.941% |
| 10 | 3.153% | 7.068% |
| 15 | 5.678% | 12.913% |
| 20 | 10.172% | 21.439% |
Relationships between endpoints
↥Index endpoint: D3_HAEMORRHAGCIRGUANTICO – Haemorrhagic disorder due to circulating anticoagulants
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data