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Sexual dysfunction

DOID EFO Endpoint Browser PheWeb

F5_SEXDYS

sexual dysfunction: ['Disturbances in sexual desire and the psychophysiologic changes that characterize the sexual response cycle and cause marked distress and interpersonal difficulty.']

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — F52
  • Hospital discharge: ICD-9 — 3027
  • Cause of death: ICD-10 — F52
  • Cause of death: ICD-9 — 3027

2 out of 7 registries used, show all original rules.

555

4. Check minimum number of events

None

555

5. Include endpoints

None

555

6. Filter based on genotype QC (FinnGen only)

555

Control definitions (FinnGen only)

Control exclude
F5_BEHAVE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
F50-F59
Name in latin
Perturbationes sexuales non organicae

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3670 859 2778
Only index persons 3531 836 2695
Unadjusted period prevalence (%)
Whole population 0.06 0.02 0.08
Only index persons 0.09 0.03 0.10
Median age at first event (years)
Whole population 40.63 32.07 43.31
Only index persons 40.15 31.85 42.72

-FinnGen-

Key figures

All Female Male
Number of individuals 555 160 395
Unadjusted period prevalence (%) 0.14 0.05 0.17
Median age at first event (years) 47.78 37.94 51.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
479
Matched controls
4788
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
F52.2
ICD-10 Finland
Failure of genital response
94.6
186.1
200
36
F52.0
ICD-10 Finland
Lack or loss of sexual desire
211.9
86.4
87
5
F52.9
ICD-10 Finland
Unspecified sexual dysfunction, not caused by organic disorder or disease
297.3
53.3
53
*
F52.6
ICD-10 Finland
Nonorganic dyspareunia
200.0
36.3
37
*
N48.4
ICD-10 Finland
Impotence of organic origin
13.5
34.5
61
51
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
6.6
34.4
95
173
F52
ICD-10 Finland
Sexual dysfunction, not caused by organic disorder or disease
35.4
23.6
30
9
F52.4
ICD-10 Finland
Premature ejaculation
126.1
22.8
24
*
F52.8
ICD-10 Finland
Other sexual dysfunction, not caused by organic disorder or disease
76.8
19.9
22
*
F52.3
ICD-10 Finland
Orgasmic dysfunction
+∞
17.8
17
*
N05AH04
ATC
quetiapine; oral
3.0
17.5
113
443
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.3
16.8
93
326
F52.5
ICD-10 Finland
Nonorganic vaginismus
+∞
16.8
16
*
N06AX11
ATC
mirtazapine; oral
2.4
16.1
168
868
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
14.0
70
226
N06AB05
ATC
paroxetine; oral
4.2
13.3
52
136
N94.1
ICD-10 Finland
Dyspareunia
15.6
13.2
21
14
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
4.7
12.9
44
101
N06AB06
ATC
sertraline; oral
3.1
12.7
73
261
N06AX12
ATC
bupropion; oral
3.8
12.4
54
156
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
5.0
11.9
38
81
N05AX12
ATC
aripiprazole; systemic
4.6
11.9
41
95
N05BA04
ATC
oxazepam; oral
2.3
11.8
121
606
N06AB04
ATC
citalopram; systemic
2.4
11.6
114
557
F50.9
ICD-10 Finland
Eating disorder, unspecified
122.8
11.5
12
*
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.7
10.7
36
82
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.2
10.5
55
184
N05CF01
ATC
zopiclone; oral
2.1
10.3
134
741
N05AH03
ATC
olanzapine; systemic
3.5
10.3
49
153
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
3.0
10.1
59
213
XKD00
NOMESCO Finland
Uroflowmetry
2.5
10.1
86
388
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
9.9
122
658
N06AX16
ATC
venlafaxine; oral
2.6
9.8
77
333
F34.1
ICD-10 Finland
Dysthymia
5.1
9.5
29
60
XCW99
NOMESCO Finland
Other investigative procedure of eye
3.1
9.4
53
187
N06AB10
ATC
escitalopram; oral
2.2
9.3
111
586
N02AX02
ATC
tramadol; systemic, rectal
1.9
9.2
185
1201
N03AE01
ATC
clonazepam; systemic
3.7
9.2
39
111
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.3
9.1
45
145
R06.0
ICD-10 Finland
Dyspnoea
2.2
9.1
106
558
A04
ICPC
Weakness/tiredness general
2.8
9.0
59
228
P29
ICPC
Psychological sympt/compl other
3.4
9.0
43
135
R07.4
ICD-10 Finland
Chest pain, unspecified
2.1
9.0
118
653
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.5
8.9
71
307
F51.0
ICD-10 Finland
Nonorganic insomnia
2.6
8.9
65
269
Z01.7
ICD-10 Finland
Laboratory examination
2.8
8.8
58
224
N05CD07
ATC
temazepam; oral
2.9
8.8
54
201
N03AG01
ATC
valproic acid; systemic, rectal
3.3
8.8
43
138
N05BA01
ATC
diazepam; systemic, rectal
2.6
8.7
67
284
K59.09
ICD-10 Finland
Constipation, unspecified
4.2
8.7
32
80
A06AC01
ATC
ispaghula (psylla seeds); oral
2.2
8.6
94
477
N03AX09
ATC
lamotrigine; oral
3.6
8.4
37
109
N05AX08
ATC
risperidone; systemic
3.0
8.2
47
168
R51.80
ICD-10 Finland
Headache
2.3
8.1
76
357
H04.10
ICD-10 Finland
Dry eye syndrome
3.2
8.1
41
135
R53
ICD-10 Finland
Malaise and fatigue
2.2
8.0
89
457
SPAT1240
SPAT
Therapeutic discussion
2.4
8.0
66
294
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.1
7.7
91
479
A02BC02
ATC
pantoprazole; systemic
1.7
7.7
272
2076
N06AB03
ATC
fluoxetine; oral
2.5
7.7
61
265
R4110
NOMESCO Finland
Physiotherapy
1.9
7.6
117
683
C07AA05
ATC
propranolol; systemic
2.1
7.6
88
460
F41.1
ICD-10 Finland
Generalized anxiety disorder
3.8
7.5
30
82
Z71.8
ICD-10 Finland
Other specified counselling
1.9
7.4
112
649
R35
ICD-10 Finland
Polyuria
3.2
7.4
38
127
N06AX22
ATC
agomelatine; oral
7.0
7.4
17
25
3027C
ICD-9 Finland
Sexual deviations and disorders, Psychosexual dysfunction[SEKSUAALINEN KIIHOTTUMISVAIKEUS]
+∞
7.3
7
*
N05CF02
ATC
zolpidem; oral
2.1
7.3
84
438
N05AB03
ATC
perphenazine; systemic, rectal
3.9
7.2
28
75
SAA01
NOMESCO Finland
Simple examination of mouth
1.7
7.0
337
2775
XKD06
NOMESCO Finland
Physiologic investigation of micturition
4.8
7.0
22
48
R06.5
ICD-10 Finland
Mouth breathing
2.4
6.8
56
247
N06AG02
ATC
moclobemide; oral
3.8
6.8
27
74
N01
ICPC
Headache
2.6
6.8
50
209
G04BE04
ATC
yohimbine; oral
17.0
6.8
10
6
LC2AE
NOMESCO Finland
Ultrasound examination of uterus and parametria
2.9
6.7
40
148
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
6.7
151
996
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
1.9
6.6
97
552
S18
ICPC
Laceration/cut
1.7
6.6
174
1203
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.9
6.4
108
648
F50.2
ICD-10 Finland
Bulimia nervosa
70.8
6.4
7
*
N03AX16
ATC
pregabalin; oral
1.9
6.4
99
574
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
5.6
6.4
17
31
N03AX12
ATC
gabapentin; oral
2.2
6.4
65
320
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
6.3
62
298
E73.8
ICD-10 Finland
Other lactose intolerance
+∞
6.3
6
*
Z70.9
ICD-10 Finland
Sex counselling, unspecified
27.1
6.2
8
*
L03
ICPC
Low back symptom/complaint
1.9
6.2
101
596
R10.2
ICD-10 Finland
Pelvic and perineal pain
5.9
6.2
16
28
A02BC03
ATC
lansoprazole; oral
1.8
6.2
112
688
R01AD09
ATC
mometasone; nasal
1.6
6.2
201
1465
N06AX21
ATC
duloxetine; oral
2.3
6.1
54
247
A02BA02
ATC
ranitidine; systemic
2.1
6.1
69
354

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
176
591
3.90
45.09
3.3
2.2
14.1
13.8
nmol/l
0.12
168
547
100
262
4.44
35.41
2.4
1.7
35.6
37.8
nmol/l
0.55
100
253
72
184
4.35
26.05
1.6
1.4
5.4
7.7
u/l
1.42
60
157
407
3122
2.14
13.95
4.8
3.4
14.6
14.7
pmol/l
0.13
382
2872
471
3896
2.38
12.38
5.7
4.0
1.9
1.8
mu/l
0.03
443
3613
27
57
4.93
12.25
1.9
1.5
—
—
—
0
0
346
2576
1.91
11.96
4.8
3.6
178.7
132.7
e6/l
—
6
35
221
1459
1.86
10.85
2.2
1.8
99.1
94.4
pmol/l
0.81
120
817
306
2244
1.81
10.54
7.6
6.4
0.2
0.2
e9/l
0.28
273
2012
58
234
2.65
9.97
3.1
3.7
4.6
4.7
pmol/l
0.33
51
212
401
3226
1.88
9.85
9.2
7.9
76.8
76.8
u/l
0.01
379
3068
295
2171
1.77
9.75
7.6
6.0
0.0
0.0
e9/l
0.08
263
1925
294
2165
1.76
9.67
7.5
6.0
0.6
0.6
e9/l
0.01
260
1916
300
2241
1.74
9.21
7.5
6.2
1.8
2.0
e9/l
1.20
270
2011
386
3110
1.79
8.95
4.5
3.7
9.6
9.9
mm/h
0.12
371
2907
254
1824
1.72
8.89
3.3
2.6
116.5
139.1
ug/l
0.94
241
1719
325
2499
1.73
8.84
11.9
9.5
3.8
4.1
e9/l
1.62
286
2212
253
1818
1.72
8.81
8.8
7.4
1.2
1.2
mmol/l
0.24
227
1572
144
882
1.85
8.65
3.7
3.1
—
—
—
0
0
145
895
1.84
8.48
2.2
2.0
2.7
2.9
mg/l
0.62
131
786
358
2852
1.72
8.32
4.2
3.7
—
—
—
0
0
69
329
2.25
8.25
1.4
1.2
—
—
—
0
0
232
1651
1.70
8.22
8.2
6.6
1.2
1.2
mmol/l
0.12
216
1525
144
897
1.82
8.14
1.6
1.3
2.3
2.4
g/l
0.40
89
594
172
1136
1.74
7.94
2.9
2.1
337.8
275.0
u/l
0.23
160
1082
265
1971
1.66
7.81
7.5
6.3
0.7
0.7
%
0.82
254
1868
165
1082
1.75
7.79
2.2
1.9
—
—
—
0
0
273
2050
1.65
7.73
7.8
6.6
8.8
8.6
%
0.54
262
1951
277
2088
1.65
7.72
7.2
6.0
56.2
57.0
%
0.45
265
1988
123
742
1.84
7.67
4.3
3.5
172.1
663.9
ng/l
2.04
86
542
164
1083
1.73
7.51
3.7
2.9
0.2
0.4
e6/l
0.64
112
833
270
2040
1.63
7.33
7.6
6.2
3.1
2.9
%
0.81
257
1929
278
2118
1.63
7.28
7.6
6.2
28.8
28.2
%
0.39
265
2008
45
189
2.50
7.14
1.7
1.3
15.2
20.7
iu/l
0.63
36
158
187
1297
1.67
7.07
3.7
2.8
56.6
57.5
u/l
0.15
174
1222
198
1394
1.65
7.06
4.4
3.3
71.9
107.5
e6/l
0.33
130
1013
157
1042
1.71
6.99
6.2
4.4
7.4
7.4
ph
0.03
17
191
107
637
1.84
6.91
3.3
2.7
0.9
1.2
e6/l
0.58
49
362
93
531
1.90
6.84
1.3
1.3
—
—
—
0
0
148
975
1.71
6.74
1.4
1.2
3.3
1.0
u/ml
0.71
44
287
153
1018
1.69
6.72
7.4
6.6
—
—
—
0
0
158
1067
1.67
6.53
3.8
2.8
—
—
—
0
0
174
1206
1.65
6.50
3.7
2.9
29.7
99.8
e6/l
0.70
121
950
215
1571
1.60
6.47
2.1
2.0
—
—
—
0
0
106
642
1.80
6.45
2.8
3.6
0.8
0.8
mmol/l
0.07
97
616
501
4527
2.10
6.40
19.5
13.6
139.6
139.7
mmol/l
0.07
491
4413
221
1630
1.59
6.37
5.1
5.5
36.4
36.4
g/l
0.03
204
1542
500
4525
2.06
6.20
17.7
12.5
21.5
23.3
mg/l
0.63
406
3491
39
164
2.48
6.19
3.4
2.6
1008.8
2797.7
u/l
—
9
63
127
822
1.71
6.11
1.8
1.4
20.2
19.8
nmol/l
0.14
118
711
501
4544
2.05
6.06
20.0
13.8
4.0
4.0
mmol/l
0.11
492
4424
308
2476
1.55
5.94
6.0
5.0
6.9
6.7
mmol/l
0.80
295
2311
150
1028
1.63
5.77
4.3
4.0
90.6
90.9
%
0.05
143
1014
476
4268
1.81
5.65
5.1
4.0
6.1
5.9
mmol/l
1.06
442
3963
192
1408
1.56
5.50
6.7
6.0
—
—
—
0
0
90
545
1.78
5.44
3.6
2.4
2.3
2.3
g/l
0.42
83
508
454
4035
1.69
5.34
6.7
5.1
40.2
39.5
mmol/mol
0.73
434
3819
271
2151
1.51
5.33
7.2
7.0
11.4
11.9
umol/l
0.23
254
2050
50
250
2.10
5.33
2.3
1.9
—
—
—
0
0
102
646
1.71
5.27
1.5
1.2
14.0
7.7
u/ml
0.51
48
262
84
504
1.79
5.24
3.8
2.5
23.4
24.5
%
0.39
78
440
93
575
1.74
5.23
1.8
2.5
113.8
122.2
ug/g
0.11
72
475
68
382
1.89
5.23
2.3
1.9
372.1
365.4
nmol/l
0.10
62
358
81
488
1.77
4.98
2.2
1.6
—
—
—
0
0
137
949
1.59
4.96
1.9
1.7
0.6
1.2
mg/l
5.12
107
717
76
450
1.80
4.95
20.9
20.6
1.2
1.3
inr
0.28
11
64
106
692
1.66
4.87
1.5
1.2
16.9
30.1
iu/ml
1.39
23
213
28
114
2.53
4.79
3.2
2.2
—
—
—
0
0
256
2039
1.47
4.78
3.8
3.0
0.0
0.0
estimate
0.00
27
367
82
503
1.74
4.73
9.0
6.8
1.1
1.0
mmol/l
0.93
76
482
42
206
2.12
4.72
2.6
1.8
—
—
—
0
0
44
221
2.08
4.65
6.2
4.5
113.4
87.4
ng/l
0.83
38
204
163
1191
1.52
4.62
3.4
3.5
2.4
2.3
mmol/l
0.54
143
1074
175
1303
1.50
4.52
3.6
3.2
8.4
8.7
mmol/l
0.30
154
1124
50
269
1.94
4.39
1.6
1.7
—
—
—
0
0
50
270
1.94
4.34
2.3
1.9
—
—
—
0
0
251
2021
1.44
4.29
3.8
3.0
0.0
0.0
estimate
0.00
29
386
82
517
1.69
4.29
1.6
1.5
—
—
—
0
0
26
108
2.48
4.28
3.0
3.2
—
—
—
0
0
88
566
1.66
4.27
1.6
1.3
240.0
409.7
titre
1.70
15
103
50
272
1.92
4.25
2.3
1.9
—
—
—
0
0
98
650
1.62
4.21
2.0
1.7
—
—
—
0
0
250
2017
1.44
4.20
4.9
4.2
0.0
0.0
estimate
0.00
29
395
50
274
1.91
4.16
2.3
1.8
—
—
—
0
0
36
175
2.13
4.16
4.9
3.5
24.4
24.0
mmol/l
0.34
30
162
18
63
2.92
4.10
1.7
1.4
32.4
51.1
pmol/l
—
9
18
25
106
2.42
3.96
1.3
1.3
—
—
—
0
0
116
816
1.53
3.86
2.9
2.4
3.4
5.2
e6/l
0.69
102
725
254
2084
1.40
3.75
4.2
4.2
2.5
2.0
ug/l
0.22
233
1898
31
150
2.13
3.64
1.2
1.2
—
—
—
0
0
150
1931
0.69
3.55
3.1
2.5
—
—
—
0
0
125
909
1.48
3.53
3.9
3.2
1.0
1.0
kg/l
0.65
11
122
120
872
1.48
3.39
3.2
2.6
—
—
—
0
0
150
1142
1.43
3.32
3.6
3.4
419.5
231.3
mg/l
0.21
112
786
26
122
2.19
3.31
1.1
1.2
—
—
—
0
0
21
90
2.39
3.28
1.0
1.1
2.2
6.6
u/ml
—
10
50
107
765
1.49
3.27
2.9
2.6
533.7
585.6
mosm/kgh2o
1.68
86
660
87
595
1.55
3.27
1.9
1.6
1276.7
1190.6
nmol/l
0.19
70
481
52
313
1.73
3.23
3.8
3.2
—
—
—
0
0
489
4572
1.58
3.11
5.4
4.3
2.8
2.8
mmol/l
0.76
463
4295
33
175
1.94
3.07
3.7
2.4
—
—
—
0
0
10
29
3.49
3.06
2.1
1.4
—
—
—
0
0
6
9
6.72
2.87
1.0
1.0
—
—
—
0
0
6
9
6.72
2.87
1.3
1.1
—
—
—
0
0
86
604
1.50
2.87
2.6
2.1
—
—
—
0
0
341
3013
1.34
2.84
4.2
3.4
—
—
—
0
0
193
1572
1.35
2.78
4.2
3.2
19.3
39.9
ng/l
3.67
113
979
113
845
1.42
2.73
1.8
1.7
—
—
—
0
0
55
354
1.61
2.69
4.9
3.3
1.9
1.8
mmol/l
0.12
47
279
9
24
3.79
2.68
5.8
2.7
—
—
—
0
0
60
395
1.58
2.68
3.7
2.9
1.7
1.7
%
0.11
54
359
19
86
2.25
2.66
1.0
1.1
0.4
1.0
u/ml
—
10
32
55
356
1.60
2.63
4.7
3.3
5.9
5.7
kpa
0.35
50
346
141
1106
1.37
2.56
2.4
2.6
364.4
5966.8
umol/l
3.55
121
988
12
44
2.77
2.56
1.2
1.2
—
—
—
0
0
511
4865
1.64
2.55
13.1
9.6
28.7
30.9
u/l
1.90
499
4737
6
11
5.50
2.55
1.2
1.1
—
—
—
0
0
83
594
1.47
2.53
3.4
3.2
2.4
2.4
mmol/l
0.38
72
528
53
345
1.59
2.49
4.8
4.4
—
—
—
0
0
52
337
1.60
2.49
13.1
9.3
—
—
—
0
0
10
34
2.98
2.42
5.6
1.4
288.8
285.4
mosm/kgh2o
—
5
27
155
1245
1.34
2.41
2.5
2.7
0.7
0.7
ug/l
0.36
95
724
20
97
2.10
2.40
1.0
1.1
0.2
2.6
u/ml
—
9
41
23
118
1.99
2.39
1.2
1.1
—
—
—
0
0
224
1901
1.30
2.34
11.7
9.0
0.0
0.0
e9/l
0.55
180
1577
15
65
2.34
2.33
1.6
2.0
—
—
—
0
0
478
4507
1.44
2.29
4.9
4.0
1.3
1.4
mmol/l
1.47
455
4245
23
120
1.96
2.29
3.0
3.1
1.4
1.4
mg/l
0.16
23
112
136
1079
1.34
2.28
5.7
4.5
—
—
—
0
0
29
164
1.81
2.27
2.3
2.2
—
—
—
0
0
479
4522
1.43
2.24
5.0
4.0
4.6
4.7
mmol/l
1.39
456
4274
68
480
1.47
2.23
1.4
1.4
—
—
—
0
0
63
441
1.48
2.16
9.5
9.6
0.9
0.9
mmol/l
0.01
49
350
6
14
4.32
2.15
2.8
1.8
—
—
—
0
0
148
1206
1.31
2.05
4.6
4.1
8.2
10.3
mg/mmol
0.39
107
820
230
1984
1.27
2.05
4.2
4.1
—
—
—
0
0
57
396
1.49
2.03
2.7
2.6
40.1
150.4
u/l
0.46
49
347
59
413
1.48
2.03
1.4
1.6
—
—
—
0
0
96
735
1.37
2.02
1.9
1.6
478.8
23920171.1
pmol/l
0.69
83
648
21
112
1.91
1.99
1.5
1.4
—
—
—
0
0
18
91
2.01
1.97
1.1
1.1
—
—
—
0
0
8
27
2.99
1.94
1.1
1.0
—
—
—
0
0
6
16
3.78
1.94
2.8
1.7
—
—
—
0
0
10
39
2.59
1.93
1.3
1.3
—
—
—
0
0
141
1151
1.30
1.92
1.7
1.7
1.4
1.5
mmol/l
0.36
123
996
462
4370
1.34
1.83
4.5
3.6
1.4
1.4
mmol/l
0.18
430
4112
5
12
4.19
1.82
1.8
1.7
20.6
17.1
umol/l
—
5
12
40
264
1.56
1.82
2.7
3.0
5.1
5.1
kpa
0.15
40
250
43
289
1.53
1.81
2.2
3.0
65.9
70.2
e9/l
0.24
25
223
7
23
3.07
1.80
1.1
1.3
190.7
162.1
nmol/l
—
7
23
533
5178
1.74
1.80
26.2
17.9
246.0
246.7
e9/l
0.10
521
5071
187
1594
1.26
1.80
7.0
7.9
1.1
1.2
inr
0.71
38
494
45
307
1.51
1.77
2.3
2.3
—
19.6
—
0
21
10
41
2.47
1.76
1.7
1.6
—
—
—
0
0
8
30
2.69
1.73
1.1
1.6
33.7
34.7
g/l
—
8
24
8
30
2.69
1.73
8.5
6.6
—
—
—
0
0
8
30
2.69
1.73
4.4
3.3
—
—
—
0
0
7
24
2.94
1.72
1.3
1.1
—
—
—
0
0
47
326
1.48
1.72
5.1
4.6
0.0
0.2
%
3.56
13
100
533
5184
1.71
1.70
26.3
17.8
4.6
4.7
e12/l
0.22
522
5074
533
5187
1.70
1.66
26.3
17.9
6.7
6.7
e9/l
0.04
522
5072
10
43
2.35
1.61
1.6
1.3
—
—
—
0
0
8
32
2.52
1.60
1.0
1.2
—
—
—
0
0
46
323
1.46
1.59
3.9
4.4
0.4
0.3
%
—
10
84
6
20
3.02
1.58
1.0
1.0
—
—
—
0
0
26
161
1.65
1.55
2.0
1.6
—
—
—
0
0
8
33
2.44
1.54
2.4
2.8
37.7
20.8
mu/l
—
8
33
501
4826
1.39
1.52
14.6
11.6
—
—
—
0
0
41
285
1.47
1.50
2.0
1.6
1.0
1.4
g/l
1.96
41
265
16
87
1.86
1.47
2.0
3.0
—
—
—
0
0
25
156
1.63
1.46
2.3
2.7
—
—
—
0
0
29
188
1.57
1.46
1.3
1.4
—
9.1
—
0
11
39
271
1.47
1.44
1.1
1.1
—
—
—
0
0
5
16
3.14
1.44
5.8
4.6
—
—
—
0
0
27
407
0.65
1.42
1.4
1.4
—
—
—
0
0
24
150
1.63
1.40
1.8
1.7
—
—
—
0
0
7
29
2.43
1.39
1.1
1.8
—
—
—
0
0
5
121
0.41
1.39
1.6
1.4
—
—
—
0
0
48
350
1.41
1.38
5.0
4.5
0.5
0.8
%
0.62
14
110
5
122
0.40
1.38
1.6
1.4
—
—
—
0
0
152
1300
1.23
1.38
2.9
2.3
—
—
—
0
0
5
123
0.40
1.38
1.6
1.5
—
—
—
0
0
42
299
1.44
1.38
3.5
2.6
4.7
4.7
kpa
0.04
37
289
128
1075
1.25
1.37
4.7
3.2
0.0
0.0
estimate
0.88
27
371
23
143
1.63
1.37
1.4
1.2
—
—
—
0
0
15
82
1.85
1.37
1.4
1.4
—
—
—
0
0
5
17
2.96
1.36
1.6
1.2
—
—
—
0
0
43
309
1.42
1.35
5.3
4.6
0.0
0.2
%
0.91
12
86
17
98
1.76
1.32
1.1
1.1
—
—
—
0
0
8
35
2.30
1.27
2.4
4.2
—
—
—
0
0
35
245
1.46
1.27
1.3
1.2
—
—
—
0
0
8
36
2.24
1.24
1.0
1.0
—
—
—
0
0
31
214
1.48
1.21
2.3
2.5
—
—
—
0
0
6
26
2.32
1.19
1.0
1.4
—
—
—
0
0
66
521
1.30
1.18
2.8
3.2
8.1
9.2
umol/l
0.13
56
459
34
242
1.43
1.15
1.1
1.2
—
—
—
0
0
34
244
1.42
1.10
5.2
9.1
23.5
24.3
mmol/l
0.47
34
229
7
32
2.20
1.08
1.1
1.0
—
—
—
0
0
7
32
2.20
1.08
1.0
1.2
—
—
—
0
0
37
272
1.39
1.06
1.2
1.3
26.3
158.7
iu/ml
—
8
109
7
34
2.07
1.03
1.1
1.0
—
—
—
0
0
11
189
0.57
1.02
1.2
1.6
—
—
—
0
0
22
147
1.52
1.02
8.5
10.0
—
—
—
0
0
35
257
1.39
1.01
3.1
6.5
—
—
—
0
0
27
189
1.45
1.01
3.0
3.2
—
—
—
0
0
9
49
1.85
0.99
1.0
1.4
—
—
—
0
0
47
365
1.31
0.96
3.3
2.2
11.1
10.4
g/l
0.29
47
335
0
31
0.00
0.96
0.0
4.2
—
44.9
—
0
31
20
133
1.52
0.95
1.1
1.1
—
—
—
0
0
12
70
1.73
0.93
1.3
1.2
—
—
—
0
0
32
237
1.37
0.90
3.3
2.3
—
—
—
0
0
12
72
1.68
0.85
1.6
1.2
5.2
4.1
u/ml
—
6
37
14
88
1.61
0.85
1.0
1.1
2.5
3.6
u/ml
—
7
21
26
353
0.72
0.85
6.0
3.2
—
—
—
0
0
10
57
1.77
0.84
3.0
3.9
—
—
—
0
0
59
483
1.25
0.83
1.2
1.3
—
—
—
0
0
8
47
1.71
0.81
1.1
1.2
1.1
1.2
nmol/l
—
8
42
8
48
1.68
0.79
1.0
1.4
—
—
nmol/l
—
0
0
12
74
1.64
0.78
1.0
1.1
7.2
3.0
u/ml
—
6
29
22
157
1.42
0.78
1.2
1.2
0.2
2.3
u/ml
—
5
12
0
27
0.00
0.77
0.0
1.0
—
238.5
—
0
27
5
25
2.01
0.73
4.4
1.4
—
—
—
0
0
403
3876
1.15
0.72
21.7
14.8
13.6
13.5
%
0.56
398
3802
11
68
1.63
0.72
2.5
1.8
—
—
—
0
0
9
57
1.59
0.71
2.3
1.7
—
—
—
0
0
9
58
1.56
0.70
1.3
1.3
—
—
—
0
0
29
222
1.32
0.69
10.6
12.9
—
—
—
0
0
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
11
70
1.58
0.65
1.0
1.1
1.4
1.5
g/l
0.36
11
63
451
4383
1.15
0.65
18.3
12.8
41.3
41.4
%
0.10
359
3470
23
172
1.35
0.64
3.3
3.5
25.0
24.6
mmol/l
0.41
23
164
12
79
1.53
0.63
1.0
1.0
1.9
2.4
u/ml
—
7
30
8
49
1.64
0.62
1.5
1.3
0.4
0.4
g/l
—
8
32
8
49
1.64
0.62
1.5
1.3
6.8
6.9
g/l
—
8
33
5
30
1.67
0.61
1.4
1.8
14.8
12.3
umol/l
—
5
30
8
50
1.61
0.61
1.5
1.3
—
—
—
0
0
13
88
1.49
0.61
1.2
1.1
—
10.7
—
0
9
25
192
1.32
0.60
1.6
1.2
—
—
—
0
0
12
80
1.51
0.60
1.2
1.2
—
—
—
0
0
21
157
1.35
0.60
6.0
4.9
—
—
—
0
0
32
258
1.26
0.55
1.6
1.5
—
—
—
0
0
9
63
1.44
0.52
2.7
2.6
—
—
—
0
0
6
40
1.51
0.51
2.7
2.3
34.0
33.9
pg
—
6
40
6
41
1.47
0.50
1.0
1.0
293.3
290.1
mg/l
—
6
36
10
67
1.50
0.50
1.3
1.2
—
—
—
0
0
108
1186
0.89
0.50
3.4
2.6
—
—
—
0
0
7
46
1.53
0.48
1.7
1.9
—
35.4
—
0
7
5
81
0.61
0.46
5.2
3.4
51.8
55.1
%
—
5
81
5
31
1.62
0.43
2.0
4.1
—
—
—
0
0
19
149
1.28
0.42
2.6
4.2
0.2
0.2
g/l
—
9
79
8
58
1.38
0.41
1.4
1.6
—
—
—
0
0
8
58
1.38
0.41
1.4
1.6
—
—
—
0
0
8
58
1.38
0.41
1.4
1.6
—
—
—
0
0
8
58
1.38
0.41
1.4
1.6
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
6.8
—
0
5
24
197
1.23
0.38
1.2
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.4
—
—
—
0
0
5
36
1.39
0.38
1.2
1.2
—
—
—
0
0
113
1047
1.10
0.37
5.5
4.7
—
—
—
0
0
8
114
0.70
0.37
1.0
1.1
—
—
—
0
0
19
152
1.26
0.37
2.5
2.1
21.6
21.8
s
0.06
14
139
10
72
1.40
0.37
3.2
3.6
10.4
3.5
u/ml
—
10
67
5
78
0.64
0.36
5.2
3.2
3.2
4.2
e9/l
—
5
78
6
43
1.40
0.35
2.0
2.7
—
—
—
0
0
31
265
1.18
0.34
2.5
3.0
130.5
131.9
ng/l
0.01
26
235
34
294
1.17
0.33
1.3
1.4
—
—
—
0
0
63
571
1.12
0.32
2.1
1.7
—
—
—
0
0
11
83
1.33
0.32
1.0
3.6
—
—
—
0
0
7
96
0.73
0.31
4.0
3.4
—
—
—
0
0
7
56
1.25
0.29
1.6
1.1
—
—
—
0
0
116
1090
1.08
0.29
4.0
3.5
—
—
—
0
0
56
509
1.11
0.28
1.6
1.4
—
—
—
0
0
9
116
0.77
0.27
1.1
1.1
—
—
—
0
0
9
116
0.77
0.27
1.1
1.1
—
—
—
0
0
20
168
1.20
0.27
3.0
3.0
—
—
—
0
0
37
329
1.13
0.26
3.0
3.2
4.1
4.1
e9/l
0.05
32
271
5
38
1.32
0.23
2.6
1.4
—
—
—
0
0
5
42
1.19
0.21
1.6
2.1
471.0
442.3
e6/l
—
5
36
28
314
0.89
0.21
1.7
1.3
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
3.5
—
6397.1
—
0
12
0
14
0.00
0.20
0.0
3.1
—
—
—
0
0
141
1354
1.06
0.20
1.5
1.5
—
—
—
0
0
6
50
1.20
0.19
1.7
1.2
—
—
—
0
0
6
50
1.20
0.19
1.3
1.3
—
—
—
0
0
6
52
1.16
0.19
3.3
2.2
—
—
—
0
0
18
156
1.16
0.19
1.9
2.0
0.6
1.7
ug/l
0.98
18
140
6
53
1.13
0.18
3.5
2.3
—
—
—
0
0
8
68
1.18
0.16
1.4
1.4
—
—
—
0
0
65
684
0.94
0.14
1.3
1.3
—
—
—
0
0
10
84
1.19
0.14
2.8
3.3
—
—
—
0
0
51
540
0.94
0.13
1.5
1.7
—
—
—
0
0
29
267
1.09
0.13
7.1
4.6
1.2
1.2
mmol/l
0.41
24
241
12
104
1.16
0.12
6.3
4.1
7.4
7.4
ph
—
7
87
62
649
0.95
0.12
1.3
1.4
—
—
—
0
0
19
172
1.11
0.11
3.9
7.5
2.2
1.6
%
0.81
19
160
6
57
1.05
0.08
1.0
1.1
—
—
—
0
0
16
146
1.10
0.08
1.3
1.1
—
—
—
0
0
6
71
0.84
0.07
1.0
1.6
—
—
—
0
0
34
354
0.96
0.05
3.7
5.3
2.9
45.6
ug/l
1.14
26
292
18
170
1.06
0.04
4.1
7.6
0.9
0.9
%
0.07
18
159
20
193
1.04
0.01
5.1
3.1
25.7
24.7
mmol/l
0.77
20
186
10
95
1.05
0.00
1.2
1.2
—
—
—
0
0
14
136
1.03
0.00
2.1
1.5
0.2
0.2
g/l
0.14
14
131
14
144
0.97
0.00
2.2
1.5
1.2
1.2
g/l
0.10
14
138
10
99
1.01
0.00
3.9
10.9
14.5
11.5
mmol/l
—
10
91
10
99
1.01
0.00
3.9
10.9
105.3
105.3
mmol/l
—
10
91
6
66
0.91
0.00
1.2
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
1.4
—
0
5
0
9
0.00
0.00
0.0
10.3
—
—
—
0
0
0
8
0.00
0.00
0.0
6.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
42.2
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
4.2
—
—
—
0
0
6
62
0.97
0.00
12.3
3.5
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
—
—
0
0
0
5
0.00
0.00
0.0
2.6
—
193.2
—
0
5
17
170
1.00
0.00
1.4
1.4
175.5
240.6
miu/ml
—
8
83
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
90.2
—
0
5
0
6
0.00
0.00
0.0
3.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
7
79
0.88
0.00
1.9
1.2
—
—
—
0
0
7
74
0.95
0.00
1.4
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint F5_SEXDYS and mortality.

Females

No data

Males

Parameter HR [95% CI] p-value
F5_SEXDYS 1.439 [1.19, 1.75] < 0.001
Birth year 0.988 [0.98, 1.0] 0.026

During the follow-up period (1.1.1998 — 31.12.2019), 176 out of 1694 males with F5_SEXDYS died.

Mortality risk

Mortality risk for people of age

years, who have F5_SEXDYS.

N-year risk Females Males
1 No data 0.287%
5 No data 1.854%
10 No data 4.492%
15 No data 8.385%
20 No data 14.164%

Relationships between endpoints

↥

Index endpoint: F5_SEXDYS – Sexual dysfunction

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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