asbestosis: A pneumoconiosis caused by inhalation and retention of asbestos fibers.
Pneumoconiosis due to asbestos and other mineral fibres
DOID EFO Endpoint Browser PheWeb
J10_ASBESTPNEUMOC
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
824 |
4. Check minimum number of eventsNone |
824 |
5. Include endpointsNone |
824 |
6. Filter based on genotype QC (FinnGen only) |
824 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Asbestosis
Similar endpoints
↥List of similar endpoints to
Pneumoconiosis due to asbestos and other mineral fibres
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6025 | 326 | 5496 |
| Only index persons | 3520 | 209 | 3311 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.01 | 0.15 |
| Only index persons | 0.12 | 0.01 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 71.18 | 71.89 | 71.13 |
| Only index persons | 71.74 | 71.88 | 71.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 824 | 32 | 792 |
| Unadjusted period prevalence (%) | 0.34 | 0.01 | 0.35 |
| Median age at first event (years) | 70.27 | 61.36 | 70.63 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 736
- Matched controls
- 7358
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
86.7
323.0
445
127
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
13226.5
323.0
676
5
5010A
ICD-9 Finland
Asbestosis[ASBESTOSIS]
+∞
85.1
80
*
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
10.9
77.6
158
180
XG410
NOMESCO Finland
Flow-volume spirometry
9.8
60.8
130
158
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
13.3
58.1
105
91
R03AC02
ATC
salbutamol; inhalant
3.4
54.0
424
2097
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.4
49.2
208
603
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
9.4
46.4
100
121
R03BB04
ATC
tiotropium bromide; inhalant
3.8
45.4
230
779
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.6
45.1
178
478
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.2
38.9
265
1104
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
5.7
37.4
115
231
H02AB06
ATC
prednisolone; systemic
2.5
31.0
409
2454
R06.0
ICD-10 Finland
Dyspnoea
2.7
30.2
264
1251
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
8.0
30.1
70
95
Z57.2
ICD-10 Finland
Occupational exposure to dust
24.0
29.0
41
18
J92.9
ICD-10 Finland
Pleural plaque without asbestos
9.7
28.2
58
64
5110B
ICD-9 Finland
Pleurisy, Without mention of effusion or current tuberculosis[PLEURA-ADHEESIOT]
16.4
26.2
42
27
TGC00
NOMESCO Finland
Bronchial lavation
7.3
26.0
64
95
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
16.4
24.4
39
25
R03AK03
ATC
[D] fenoterol & other drugs for obstructive airway dis; inhalant
3.1
24.3
155
590
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.6
24.0
88
212
J45.9
ICD-10 Finland
Asthma, unspecified
2.9
23.3
160
638
J96.1
ICD-10 Finland
Chronic respiratory failure
5.1
23.0
75
159
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
21.1
375
2413
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
21.1
169
739
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.4
20.0
205
1017
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.1
19.5
115
411
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
6.5
18.6
49
80
R03BA05
ATC
fluticasone; inhalant
2.6
17.7
141
607
R03BA01
ATC
beclometasone; inhalant
2.7
17.6
129
529
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.1
17.2
55
115
J45.1
ICD-10 Finland
Nonallergic asthma
3.7
16.4
74
215
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
61.3
15.8
18
*
R03BB01
ATC
ipratropium bromide; inhalant
2.9
15.1
100
384
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
9.7
14.5
29
31
1240
FHL
Bronchoscopy
5.9
14.1
39
69
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
5.2
14.0
43
86
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
16.6
13.5
21
13
J01AA02
ATC
doxycycline; systemic
1.9
13.5
519
4134
R04.2
ICD-10 Finland
Haemoptysis
3.5
12.9
61
185
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
12.9
53
143
R03BA02
ATC
budesonide; inhalant
2.3
12.6
128
619
Z57.3
ICD-10 Finland
Occupational exposure to other air contaminants
71.1
12.6
14
*
J92
ICD-10 Finland
Pleural plaque
32.6
12.6
16
5
R03DA04
ATC
theophylline; systemic, rectal
2.4
12.6
111
500
51520
ICD-8 Finland
Pneumoconiosis due to silica and silicates, Asbestosis
+∞
12.5
12
*
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.2
12.3
46
114
R03AK07
ATC
formoterol and budesonide; inhalant
2.3
12.1
120
573
GAC00
NOMESCO Finland
Biopsy of pleura
21.7
12.0
17
8
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.4
11.4
98
435
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.0
11.3
67
240
R03AC03
ATC
terbutaline; inhalant
2.4
11.2
100
453
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
4.9
11.0
35
74
R05
ICD-10 Finland
Cough
2.2
10.9
127
649
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
10.3
297
2092
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
5.2
10.3
31
62
XG466
NOMESCO Finland
Sleep oxymetry
4.0
10.1
40
105
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
2.9
10.1
62
227
R06.2
ICD-10 Finland
Wheezing
3.6
9.8
44
129
XX1AW
NOMESCO Finland
Written report from X-ray examination without contrast peformed elsewhere
10.8
9.8
18
17
R03BA08
ATC
ciclesonide; inhalant
3.2
9.8
51
168
R03AC13
ATC
formoterol; inhalant
3.0
9.6
56
199
J94.8
ICD-10 Finland
Other specified pleural conditions
4.8
9.4
30
64
R03AC12
ATC
salmeterol; inhalant
2.7
9.3
65
257
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
8.1
8.9
19
24
H02AB04
ATC
methylprednisolone; systemic
2.1
8.9
107
556
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
8.7
139
805
J47
ICD-10 Finland
Bronchiectasis
4.3
8.5
30
72
R02
ICPC
Shortness of breath/dyspnoea
2.1
8.4
95
480
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.6
8.3
260
1846
WX725
NOMESCO Finland
Noninvasive ventilation
3.3
8.2
39
121
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.5
8.1
37
111
C03CA01
ATC
furosemide; systemic
1.6
8.1
348
2669
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
8.3
8.1
17
21
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
6.4
8.0
20
32
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
9.5
7.8
15
16
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.7
7.6
160
1009
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
5.8
7.6
20
35
XX1XW
NOMESCO Finland
Extensive written report from radiologist
4.6
7.3
24
54
XG405
NOMESCO Finland
Education on PEF monitoring
5.9
7.3
19
33
5188X
ICD-9 Finland
Other diseases of lung
7.4
7.2
16
22
Y96.0
ICD-10 Finland
Work-related condition
20.2
7.1
10
5
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
4.1
7.1
26
65
J01FA06
ATC
roxithromycin; oral
1.6
7.1
246
1777
R99
ICPC
Respiratory disease other
5.7
7.1
19
34
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.8
6.9
116
683
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.7
6.9
44
167
R03DC03
ATC
montelukast; oral
2.2
6.9
70
340
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.8
288
2178
G47.3
ICD-10 Finland
Sleep apnoea
1.8
6.6
123
744
J96.0
ICD-10 Finland
Acute respiratory failure
4.6
6.5
21
47
J62.8
ICD-10 Finland
Pneumoconiosis due to other dust containing silica
+∞
6.3
6
*
J62.0
ICD-10 Finland
Pneumoconiosis due to talc dust
+∞
6.3
6
*
R95
ICPC
Chron obstructive pulmonary disease
2.7
6.0
39
149
8041/3-C34.9
ICD-O-3
Small cell carcinoma, NOS, of lung, NOS
4.6
6.0
19
42
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
108
486
2.41
14.55
7.5
3.7
2.5
1.8
mmol/l
1.08
87
344
112
515
2.36
14.37
7.5
3.8
5.5
5.1
kpa
2.78
104
462
76
291
2.78
14.25
9.0
4.3
26.0
24.6
mmol/l
2.83
69
263
72
285
2.67
12.65
3.4
2.8
—
—
—
0
0
25
51
5.02
11.74
3.6
3.4
—
—
—
0
0
44
161
2.83
9.00
1.9
1.6
—
—
—
0
0
147
883
1.81
8.94
6.5
6.5
10.1
11.4
kpa
3.06
139
834
147
883
1.81
8.94
6.5
6.5
5.2
5.0
kpa
1.48
139
836
143
882
1.75
7.90
6.6
6.5
1.8
1.2
mmol/l
1.13
110
658
40
155
2.66
7.38
2.0
1.6
—
—
—
0
0
94
532
1.87
6.87
1.3
1.2
23.5
46.4
iu/ml
2.58
29
158
21
58
3.69
6.78
1.2
1.8
—
—
—
0
0
21
58
3.69
6.78
1.2
1.8
—
—
—
0
0
21
58
3.69
6.78
1.2
1.8
—
—
—
0
0
73
392
1.95
6.26
6.3
9.4
25.1
24.2
mmol/l
1.67
62
361
299
2316
1.46
6.02
4.6
3.4
2317.0
2592.9
ng/l
0.47
270
2050
20
59
3.45
5.89
1.6
1.9
—
—
—
0
0
25
86
2.97
5.77
3.1
2.5
28.5
26.1
mg/l
—
6
17
20
61
3.34
5.61
1.7
1.9
—
—
—
0
0
30
116
2.65
5.61
1.6
1.6
—
—
—
0
0
23
77
3.04
5.56
3.4
3.4
—
—
—
0
0
17
48
3.60
5.34
2.6
1.7
—
—
—
0
0
25
90
2.83
5.34
1.9
1.5
—
—
—
0
0
25
90
2.83
5.34
1.2
1.5
—
—
—
0
0
106
670
1.67
5.30
5.1
4.9
34.1
32.9
%
0.40
66
440
36
162
2.28
4.91
2.1
2.1
137.5
125.1
g/l
1.51
22
123
11
24
4.63
4.79
1.0
1.0
—
—
—
0
0
26
102
2.60
4.75
1.2
1.1
—
—
—
0
0
13
33
3.99
4.72
1.2
2.1
—
—
—
0
0
13
33
3.99
4.72
1.2
2.1
—
—
—
0
0
13
33
3.99
4.72
1.2
2.1
—
—
—
0
0
13
33
3.99
4.72
1.2
2.1
—
—
—
0
0
174
1268
1.47
4.64
2.4
1.8
—
—
—
0
0
144
1012
1.51
4.59
1.6
1.7
1.2
1.7
mg/l
1.47
105
814
27
111
2.48
4.50
1.9
1.4
—
—
—
0
0
24
93
2.63
4.50
1.8
1.4
—
—
—
0
0
11
27
4.12
4.17
1.0
1.0
—
—
—
0
0
25
104
2.45
4.09
1.3
1.4
—
—
—
0
0
353
2957
1.34
4.04
7.6
8.0
5.0
4.6
e9/l
1.67
304
2557
53
300
1.82
3.94
2.2
1.8
—
—
—
0
0
104
716
1.52
3.65
12.7
9.8
—
—
—
0
0
10
26
3.88
3.53
1.3
2.0
—
—
—
0
0
10
26
3.88
3.53
1.3
2.0
—
—
—
0
0
76
492
1.60
3.49
1.3
1.2
13.9
16.3
u/ml
0.09
23
167
56
335
1.72
3.48
2.5
1.9
—
—
—
0
0
23
102
2.29
3.31
1.3
1.5
—
—
—
0
0
34
178
1.95
3.23
2.1
1.5
—
—
—
0
0
10
28
3.60
3.20
1.4
2.0
—
—
—
0
0
100
703
1.48
3.18
3.1
2.5
7.0
6.7
ug/l
0.07
80
600
22
99
2.26
3.08
9.3
5.2
1126.0
418.2
iu/ml
—
5
15
10
29
3.48
3.05
1.3
1.3
2.0
7.8
ug/l
—
5
10
424
3745
1.27
2.96
5.8
3.9
17.8
16.0
mm/h
1.22
390
3390
18
76
2.40
2.91
2.2
1.5
—
—
—
0
0
22
102
2.19
2.89
3.3
3.1
59.2
61.5
%
0.26
22
102
32
173
1.88
2.80
2.7
2.4
16.6
15.4
%
0.85
20
84
21
98
2.17
2.72
2.9
2.5
5.6
4.9
e9/l
0.30
21
98
343
2981
1.26
2.65
6.1
6.1
15.4
13.7
umol/l
0.57
319
2820
18
80
2.28
2.62
1.1
1.1
6.4
2.0
u/ml
—
6
6
91
1213
0.72
2.31
3.1
3.3
2.5
2.4
mmol/l
4.21
81
1048
12
49
2.47
2.11
1.2
1.5
—
—
—
0
0
300
2622
1.23
2.09
6.9
4.6
62.9
70.3
ng/l
0.18
250
2118
338
3764
0.83
1.94
30.2
24.6
14.3
14.1
%
1.40
328
3657
10
39
2.58
1.92
2.1
2.6
—
—
—
0
0
313
2767
1.21
1.91
7.3
6.3
1.2
1.2
mmol/l
0.39
275
2464
54
375
1.47
1.90
1.7
1.8
0.6
2.7
ug/l
1.14
43
318
7
23
3.06
1.80
1.1
1.3
—
—
—
0
0
13
60
2.19
1.78
1.3
1.5
—
—
—
0
0
309
2751
1.20
1.72
3.5
3.1
71.2
63.4
u/l
0.48
268
2488
31
195
1.61
1.71
3.2
3.2
0.7
0.9
nmol/l
2.74
20
151
209
1797
1.22
1.67
3.6
3.2
7.3
7.5
mmol/l
0.35
170
1460
15
76
1.99
1.65
1.0
1.1
—
—
—
0
0
187
1595
1.22
1.61
3.6
3.2
396.3
9148.9
umol/l
6.81
142
1330
6
20
3.01
1.58
2.5
1.5
—
—
—
0
0
293
3259
0.84
1.56
4.8
5.0
23.0
22.4
%
0.29
160
1770
84
655
1.31
1.53
1.7
2.5
67.5
65.7
g/l
1.38
72
588
210
1832
1.20
1.43
2.6
2.1
213.9
288.2
u/l
0.54
191
1696
15
81
1.87
1.40
1.4
1.5
12.0
14.3
u/l
1.35
15
76
59
445
1.35
1.36
1.6
1.5
—
—
—
0
0
0
37
0.00
1.34
0.0
1.2
—
—
—
0
0
31
208
1.51
1.34
4.2
2.8
7.7
7.5
kpa
0.19
31
185
203
1780
1.19
1.31
2.9
2.5
59.5
56.7
u/l
0.34
179
1646
26
169
1.56
1.30
1.3
1.4
—
—
—
0
0
26
169
1.56
1.30
1.3
1.4
—
—
—
0
0
125
1047
1.23
1.30
2.9
2.7
2.3
2.2
g/l
1.65
110
968
119
993
1.23
1.28
3.0
2.8
20.2
22.2
%
0.89
93
858
8
35
2.30
1.27
1.0
1.3
—
—
—
0
0
167
1452
1.19
1.18
4.8
4.2
0.0
0.0
estimate
0.00
51
445
21
133
1.59
1.18
1.0
1.1
43.1
138.1
iu/ml
—
8
46
59
457
1.31
1.17
3.9
4.6
101.1
116.7
ng/l
0.64
52
390
104
869
1.23
1.12
2.3
1.8
—
—
—
0
0
7
31
2.27
1.10
1.3
1.7
—
—
—
0
0
7
32
2.20
1.08
1.3
1.7
—
—
—
0
0
330
3046
1.14
1.06
8.0
7.2
1.2
1.2
mmol/l
0.30
258
2514
397
3709
1.14
1.05
5.9
5.0
4.4
2111.0
e6/l
—
5
93
134
1156
1.19
1.05
2.8
2.7
11.7
11.8
umol/l
0.09
115
1071
43
324
1.35
1.04
4.0
4.2
24.7
23.5
mmol/l
1.64
37
291
7
35
2.01
1.00
1.1
1.1
—
88.6
—
0
7
10
175
0.57
0.99
4.2
3.9
19.5
31.9
mg/l
—
5
129
0
29
0.00
0.98
0.0
1.9
—
58.0
—
0
24
0
30
0.00
0.97
0.0
1.1
—
11.2
—
0
10
0
30
0.00
0.97
0.0
3.2
—
93.0
—
0
30
213
1920
1.15
0.96
4.6
4.0
14.0
12.9
mg/mmol
0.09
138
1314
13
77
1.70
0.95
3.6
2.9
—
—
—
0
0
41
312
1.33
0.95
1.3
1.2
—
—
—
0
0
102
871
1.20
0.91
2.2
1.7
—
—
—
0
0
8
42
1.91
0.88
1.1
1.5
—
—
—
0
0
104
897
1.18
0.84
2.5
3.4
242.6
246.7
u/l
0.17
98
838
16
105
1.53
0.82
1.4
1.4
367.5
300.7
u/l
0.25
16
100
92
1069
0.84
0.81
4.0
3.4
0.7
0.8
e6/l
0.13
52
681
17
114
1.50
0.80
1.0
1.1
—
—
—
0
0
6
33
1.82
0.79
1.7
1.2
19.5
23.8
%
—
6
24
11
66
1.68
0.79
1.4
1.3
49.8
71.0
%
—
5
45
11
66
1.68
0.79
1.0
1.4
—
109.8
—
0
14
9
53
1.71
0.75
1.0
1.0
—
—
—
0
0
12
75
1.61
0.75
1.6
1.3
—
—
—
0
0
58
480
1.22
0.74
1.9
1.6
—
—
—
0
0
445
4653
0.91
0.73
5.8
5.3
2.3
2.3
mmol/l
0.58
376
4114
438
4181
1.10
0.70
8.9
7.6
89.9
84.9
u/l
0.69
408
3899
205
1883
1.12
0.69
2.5
2.2
3.6
3.0
mg/l
1.57
163
1606
65
549
1.20
0.68
2.1
2.1
0.2
0.2
g/l
1.44
56
498
11
69
1.60
0.68
1.0
1.1
—
—
—
0
0
5
27
1.86
0.68
1.6
3.1
—
—
—
0
0
5
27
1.86
0.68
1.0
1.0
—
—
—
0
0
5
27
1.86
0.68
1.6
3.1
—
—
—
0
0
9
59
1.53
0.68
1.3
1.3
—
—
—
0
0
5
28
1.79
0.66
1.0
1.1
—
—
—
0
0
16
111
1.45
0.66
1.8
1.8
85.4
89.1
%
0.87
16
111
10
62
1.62
0.65
1.0
1.1
282.0
282.6
u/ml
—
5
31
18
129
1.40
0.64
1.6
1.4
415052.4
69092.0
e6/l
0.53
11
81
19
138
1.39
0.63
1.4
1.5
277.6
241.0
ug/g
0.39
12
91
10
63
1.59
0.62
1.3
1.5
—
—
—
0
0
5
30
1.67
0.61
1.6
2.5
—
—
—
0
0
97
1093
0.87
0.61
3.5
3.2
1.4
1.0
e6/l
0.71
56
701
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
10
64
1.57
0.58
1.3
1.5
—
—
—
0
0
283
2666
1.09
0.58
5.3
5.0
32.6
33.7
g/l
2.53
246
2468
8
53
1.51
0.58
1.3
1.1
—
—
—
0
0
0
23
0.00
0.58
0.0
1.8
—
8.8
—
0
14
10
65
1.55
0.55
1.3
1.5
—
—
—
0
0
508
5242
0.92
0.55
38.3
29.4
132.8
131.3
g/l
1.29
489
5096
19
142
1.35
0.54
1.6
1.4
1143.7
1915.3
e6/l
0.94
14
103
432
4485
0.92
0.54
24.0
19.6
66.3
67.2
ml/min/173m2
0.36
373
3781
432
4485
0.92
0.54
5.4
4.7
3.9
4.1
mmol/l
1.66
366
4007
6
38
1.58
0.54
1.0
1.1
—
—
—
0
0
437
4534
0.92
0.54
7.8
7.0
42.3
42.0
mmol/mol
0.33
363
4072
19
249
0.76
0.53
1.5
1.2
—
—
—
0
0
9
62
1.46
0.53
1.0
1.1
1.6
1.7
g/l
—
9
56
10
66
1.52
0.52
1.3
1.5
—
—
—
0
0
234
2197
1.09
0.52
3.2
2.9
174.9
183.7
ug/l
0.24
199
1974
203
1896
1.09
0.51
2.2
2.1
80.5
77.6
nmol/l
0.75
167
1606
10
67
1.50
0.50
1.3
1.5
—
—
—
0
0
10
67
1.50
0.50
1.3
1.5
—
—
—
0
0
427
4423
0.93
0.49
5.5
4.7
1.3
1.3
mmol/l
1.98
359
3895
47
402
1.18
0.47
2.3
2.1
373.7
372.5
nmol/l
0.01
40
356
59
515
1.16
0.46
3.7
3.8
1.2
1.2
mmol/l
0.25
52
449
13
94
1.39
0.46
1.1
1.1
—
—
—
0
0
5
85
0.59
0.45
1.4
1.4
5.8
601.4
e6/l
—
5
73
214
2270
0.92
0.45
3.2
3.4
0.9
0.9
ug/l
0.08
159
1660
50
432
1.17
0.45
3.5
3.3
56.8
56.6
ml/min/173m2
0.02
25
198
30
361
0.82
0.44
5.1
4.5
52.0
47.4
%
0.43
30
355
241
2541
0.93
0.44
4.5
4.6
—
—
—
0
0
81
727
1.13
0.44
3.6
3.1
225.4
294.2
ng/l
1.12
75
657
170
1588
1.09
0.43
2.0
1.9
1207.7
1145.2
nmol/l
0.41
112
1202
6
93
0.64
0.42
1.2
1.9
—
—
—
0
0
8
58
1.38
0.41
2.1
1.6
—
—
—
0
0
31
259
1.20
0.41
1.8
2.9
34.4
93.0
mg/l
0.71
26
219
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
508
5207
0.94
0.39
31.9
24.6
4.1
4.1
mmol/l
1.72
486
5034
22
178
1.24
0.39
2.5
2.4
58.2
109.2
ug/min
—
10
110
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
0
19
0.00
0.39
0.0
1.0
—
—
—
0
0
508
5205
0.94
0.39
32.0
24.4
139.3
139.6
mmol/l
1.79
488
5032
494
5066
0.94
0.39
13.4
11.0
25.1
24.9
u/l
0.06
464
4802
455
4678
0.94
0.39
6.0
5.2
6.2
6.2
mmol/l
0.03
382
4094
11
80
1.38
0.38
1.5
1.2
—
—
—
0
0
5
36
1.39
0.38
1.6
1.3
—
—
—
0
0
5
36
1.39
0.38
1.6
1.3
—
—
—
0
0
102
937
1.10
0.38
6.2
6.0
1.0
1.0
mmol/l
0.20
94
858
160
1701
0.93
0.36
1.8
1.7
19.1
18.8
nmol/l
0.10
135
1456
414
4259
0.94
0.35
4.7
4.0
2.2
2.1
mu/l
0.45
352
3705
7
52
1.35
0.31
1.6
1.3
—
—
—
0
0
7
52
1.35
0.31
1.6
1.3
—
—
—
0
0
7
96
0.73
0.31
1.7
1.3
—
—
—
0
0
211
2016
1.06
0.31
2.5
2.1
—
—
—
0
0
138
1301
1.07
0.30
5.6
4.2
273.3
332.8
ng/l
0.19
117
1166
163
1546
1.07
0.30
3.8
3.0
34.0
37.3
u/l
0.38
153
1480
10
129
0.77
0.28
1.3
1.6
—
—
—
0
0
77
711
1.09
0.28
5.2
4.1
—
—
—
0
0
77
711
1.09
0.28
8.7
7.0
13.4
12.8
mmol/l
0.27
70
673
65
707
0.91
0.27
2.3
4.0
19.2
36.5
ug/l
0.53
54
587
8
67
1.20
0.26
1.3
1.4
—
—
—
0
0
52
473
1.11
0.26
2.8
2.5
37.5
36.0
u/l
0.12
46
390
9
72
1.25
0.25
1.1
1.1
—
—
—
0
0
9
73
1.24
0.25
1.6
1.1
—
—
—
0
0
395
4043
0.96
0.25
6.0
5.8
6.2
5.2
ug/l
0.14
319
3535
11
87
1.27
0.24
1.8
1.6
—
—
—
0
0
11
136
0.81
0.23
2.1
2.1
90.5
83.5
%
0.59
11
129
142
1487
0.95
0.23
1.7
1.8
438.5
4680210.5
pmol/l
0.50
98
1218
115
1211
0.94
0.22
33.2
33.0
1.2
1.6
inr
—
7
175
57
526
1.09
0.22
2.2
2.2
9.8
11.1
nmol/l
0.62
46
442
105
1108
0.94
0.22
1.8
1.6
1.3
1.2
mmol/l
0.36
83
897
0
10
0.00
0.21
0.0
2.9
—
102.1
—
0
10
0
10
0.00
0.21
0.0
1.3
—
96.4
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
14
117
1.20
0.20
1.2
1.3
1.1
1.1
g/l
0.29
14
112
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
255
2482
1.04
0.19
4.5
4.0
0.0
0.0
estimate
0.00
66
501
190
1961
0.96
0.18
3.2
3.3
2.3
2.3
mmol/l
0.99
160
1683
7
59
1.19
0.18
1.0
1.3
—
—
u/ml
—
0
0
32
351
0.91
0.17
1.5
1.5
1.5
1.8
%
2.49
24
270
105
1005
1.05
0.16
4.5
3.0
0.8
0.8
mmol/l
0.33
98
926
199
2046
0.96
0.16
4.6
3.7
326.2
135.5
e6/l
0.34
157
1683
52
488
1.07
0.15
1.7
1.7
—
—
—
0
0
424
4300
0.97
0.14
4.8
4.2
1.2
1.2
mmol/l
0.42
356
3758
13
112
1.16
0.14
1.2
1.5
7.2
6.5
mmol/l
0.32
13
106
39
417
0.93
0.13
1.7
1.7
1.6
1.5
g/l
0.30
31
355
22
200
1.10
0.12
1.8
1.6
—
—
—
0
0
13
114
1.14
0.12
1.8
1.2
—
—
—
0
0
13
114
1.14
0.12
1.8
1.2
—
—
—
0
0
146
1421
1.03
0.11
2.3
2.6
—
—
—
0
0
27
291
0.93
0.11
2.3
2.6
12.2
11.0
g/l
0.60
22
244
355
3503
1.02
0.11
6.6
5.2
6.9
7.0
mmol/l
0.20
337
3328
11
96
1.15
0.10
3.7
6.2
11.1
12.4
mg/l
0.54
11
91
5
47
1.06
0.09
1.0
1.6
3.3
5.6
mg/l
—
5
42
191
1946
0.98
0.09
4.9
4.4
—
—
—
0
0
20
215
0.93
0.07
1.6
1.6
—
—
—
0
0
6
72
0.83
0.07
6.7
3.3
310.0
331.0
umol/l
—
6
60
12
108
1.11
0.07
1.0
1.3
—
—
—
0
0
8
92
0.87
0.06
1.3
1.6
—
—
—
0
0
30
315
0.95
0.06
2.2
2.5
4.0
3.8
g/l
0.36
21
219
63
648
0.97
0.06
2.8
2.7
19.0
11.3
umol/l
0.76
58
575
179
1813
0.98
0.05
4.5
3.6
0.5
0.5
e6/l
0.01
137
1469
70
717
0.97
0.05
1.2
1.1
1.5
1.9
u/ml
0.18
15
157
408
4058
1.01
0.04
25.2
22.1
37.1
37.3
%
0.11
194
2261
17
160
1.06
0.04
1.4
1.3
—
—
—
0
0
27
260
1.04
0.03
2.3
2.7
1.6
1.5
g/l
0.02
22
223
497
4952
1.01
0.03
27.6
20.2
27.7
31.8
mg/l
1.83
440
4215
236
2377
0.99
0.03
4.8
3.6
—
—
—
0
0
252
2503
1.01
0.03
4.7
4.0
0.0
0.0
estimate
0.00
64
477
30
290
1.04
0.03
2.2
2.5
3.2
3.1
g/l
0.30
21
223
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
34
330
1.03
0.03
2.3
2.4
0.3
0.3
u/ml
0.09
16
187
323
3244
0.99
0.02
3.9
3.1
15.4
15.1
pmol/l
1.04
277
2812
70
690
1.02
0.02
3.9
4.0
3.3
1.8
mmol/l
2.63
58
527
13
123
1.06
0.01
1.9
1.2
—
—
—
0
0
246
2449
1.01
0.01
5.7
5.4
0.0
0.0
estimate
0.00
65
495
150
1492
1.01
0.01
3.9
2.8
3.2
3.3
e6/l
0.07
136
1319
113
1124
1.01
0.00
5.1
4.6
1.0
1.0
kg/l
1.28
19
198
31
315
0.98
0.00
2.2
2.5
8.0
7.3
g/l
1.26
23
228
31
315
0.98
0.00
2.2
2.5
—
—
—
0
0
12
118
1.02
0.00
1.4
1.4
—
—
—
0
0
267
2667
1.00
0.00
2.2
2.2
93.5
89.2
pmol/l
0.72
145
1517
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
9
0.00
0.00
0.0
1.2
—
76.1
—
0
9
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
1849.5
—
0
8
0
6
0.00
0.00
0.0
1.8
—
79.2
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
9
95
0.95
0.00
1.0
1.1
—
14.1
—
0
5
Mortality – FinRegistry
↥Association
Association between endpoint J10_ASBESTPNEUMOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.687 [1.26, 2.25] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.642 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 200 females with J10_ASBESTPNEUMOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.879 [1.69, 2.09] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2029 out of 3332 males with J10_ASBESTPNEUMOC died.
Mortality risk
Mortality risk for people of age
years, who have J10_ASBESTPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.358% |
| 5 | 1.034% | 2.316% |
| 10 | 2.786% | 5.423% |
| 15 | 5.368% | 10.024% |
| 20 | 9.573% | 16.505% |
Relationships between endpoints
↥Index endpoint: J10_ASBESTPNEUMOC – Pneumoconiosis due to asbestos and other mineral fibres
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data