asbestosis: A pneumoconiosis caused by inhalation and retention of asbestos fibers.
Pneumoconiosis due to asbestos and other mineral fibres
DOID EFO Endpoint Browser PheWeb
J10_ASBESTPNEUMOC
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
855 |
4. Check minimum number of eventsNone |
855 |
5. Include endpointsNone |
855 |
6. Filter based on genotype QC (FinnGen only) |
840 |
Control definitions (FinnGen only)
- Control exclude
- J10_EXTERLUNG
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- J60-J70
- Name in latin
- Asbestosis
Similar endpoints
↥List of similar endpoints to
Pneumoconiosis due to asbestos and other mineral fibres
based on the number of shared cases.
Similar with more cases:
- Lung diseases due to external agents
- Diagnoses used for exclusion with ILD
- Diseases of the respiratory system
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6025 | 326 | 5496 |
| Only index persons | 3520 | 209 | 3311 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.15 | 0.01 | 0.15 |
| Only index persons | 0.12 | 0.01 | 0.13 |
| Median age at first event (years) | |||
| Whole population | 71.18 | 71.89 | 71.13 |
| Only index persons | 71.74 | 71.88 | 71.73 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 840 | 31 | 809 |
| Unadjusted period prevalence (%) | 0.36 | 0.01 | 0.37 |
| Median age at first event (years) | 70.71 | 60.98 | 71.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 855
- Matched controls
- 8550
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
J61
ICD-10 Finland
Pneumoconiosis due to asbestos and other mineral fibres
4503599627370496.0
307.7
792
*
J92.0
ICD-10 Finland
Pleural plaque with presence of asbestos
87.4
307.7
537
162
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
13.8
199.2
206
192
XG410
NOMESCO Finland
Flow-volume spirometry
9.8
115.2
145
174
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
12.3
111.1
117
109
J84.1
ICD-10 Finland
Other interstitial pulmonary diseases with fibrosis
10.1
105.8
129
148
5010A
ICD-9 Finland
Asbestosis[ASBESTOSIS]
+∞
90.2
85
*
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
6.6
74.7
132
230
Z57.2
ICD-10 Finland
Occupational exposure to dust
23.5
72.6
53
24
R91
ICD-10 Finland
Abnormal findings on diagnostic imaging of lung
4.2
72.4
253
786
UGC12
NOMESCO Finland
Flexible bronchoscopy
4.4
69.3
211
590
5110B
ICD-9 Finland
Pleurisy, Without mention of effusion or current tuberculosis[PLEURA-ADHEESIOT]
25.4
67.8
48
20
R03BB04
ATC
tiotropium bromide; inhalant
3.8
67.7
274
938
R03AC02
ATC
salbutamol; inhalant
3.4
67.5
523
2687
J84.9
ICD-10 Finland
Interstitial pulmonary disease, unspecified
8.5
64.9
88
114
J44.8
ICD-10 Finland
Other specified chronic obstructive pulmonary disease
3.3
59.2
318
1290
TGC00
NOMESCO Finland
Bronchial lavation
7.8
52.0
75
104
GDA98
NOMESCO Finland
Other bronchoscopic incision, excision of lesion or repair of lung
13.5
47.2
45
35
J96.1
ICD-10 Finland
Chronic respiratory failure
5.9
46.9
90
168
J92.9
ICD-10 Finland
Pleural plaque without asbestos
7.6
45.1
66
93
R03AK03
ATC
[U] fenoterol and ipratropium bromide
3.3
40.9
180
631
H02AB06
ATC
prednisolone; systemic
2.5
36.4
493
3035
R06.0
ICD-10 Finland
Dyspnoea
2.5
34.1
330
1732
J44.0
ICD-10 Finland
Chronic obstructive pulmonary disease with acute lower respiratory infection
3.3
33.7
144
492
XG470
NOMESCO Finland
Measurement of diffusion capastity of the lungs
5.6
32.8
64
121
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
3.9
31.4
99
276
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
2.5
30.8
252
1214
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.7
30.1
204
896
GD1AD
NOMESCO Finland
Thorax CT examination
3.9
29.8
94
262
J45.9
ICD-10 Finland
Asthma, unspecified
2.7
29.6
194
838
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.1
26.2
471
3106
R03AL01
ATC
fenoterol and ipratropium bromide; inhalant
4.6
25.9
64
148
J18.0
ICD-10 Finland
Bronchopneumonia, unspecified
4.9
25.8
58
124
R03BB01
ATC
ipratropium bromide; inhalant
3.0
24.3
117
426
R03BA05
ATC
fluticasone; inhalant
2.5
22.8
166
747
R03BA01
ATC
beclometasone; inhalant
2.5
21.2
152
677
R03BA02
ATC
budesonide; inhalant
2.4
19.6
157
735
J45.1
ICD-10 Finland
Nonallergic asthma
3.1
19.2
83
283
R03DA04
ATC
theophylline; systemic, rectal
2.6
19.1
126
539
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.1
19.0
83
284
Z57.3
ICD-10 Finland
Occupational exposure to other air contaminants
56.4
19.0
22
*
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
2.6
18.6
122
519
J44.1
ICD-10 Finland
Chronic obstructive pulmonary disease with acute exacerbation, unspecified
3.0
18.3
84
296
XQ858
NOMESCO Finland
Oxygen partial pressure measurement
5.9
18.2
33
58
1240
FHL
Bronchoscopy
4.7
18.1
42
92
8070/3-C34.9
ICD-O-3
Squamous cell carcinoma, NOS, of lung, NOS
4.5
18.0
45
105
XX1AW
NOMESCO Finland
Written report from X-ray examination without contrast peformed elsewhere
27.4
17.9
24
9
5150X
ICD-9 Finland
Postinflammatory pulmonary fibrosis[FIBROSIS PULMONUM E CAUSA IGNOTA]
26.2
17.0
23
9
J94.8
ICD-10 Finland
Other specified pleural conditions
4.5
16.8
41
94
R03AK08
ATC
formoterol and beclometasone; inhalant
4.5
16.5
41
95
R03AC13
ATC
formoterol; inhalant
3.2
16.4
69
231
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
40.9
16.4
20
5
R06.2
ICD-10 Finland
Wheezing
3.8
15.3
48
133
R04.2
ICD-10 Finland
Haemoptysis
3.0
15.2
68
236
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
15.1
376
2606
XX1XW
NOMESCO Finland
Extensive written report from radiologist
4.9
15.1
33
69
J01AA02
ATC
doxycycline; systemic
1.9
14.6
612
4918
R03BA08
ATC
ciclesonide; inhalant
3.0
14.4
64
221
4912B
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS OBSTRUCTIVA CUM EMPHYSEMATE]
3.9
14.4
43
115
J47
ICD-10 Finland
Bronchiectasis
4.5
14.4
35
80
GCA98
NOMESCO Finland
Other bronchoscopic procedure on bronchus
6.8
14.1
22
33
J92
ICD-10 Finland
Pleural plaque
24.2
13.8
19
8
R05
ICD-10 Finland
Cough
2.1
13.6
153
814
51520
ICD-8 Finland
Pneumoconiosis due to silica and silicates, Asbestosis
+∞
13.6
13
*
R03AK07
ATC
formoterol and budesonide; inhalant
2.1
13.0
143
754
R03AL06
ATC
olodaterol and tiotropium bromide; inhalant
3.8
12.9
39
105
C34.3
ICD-10 Finland
Malignant neoplasm: Lower lobe, bronchus or lung
3.8
12.9
40
110
R03AC03
ATC
terbutaline; inhalant
2.2
12.6
109
522
H02AB04
ATC
methylprednisolone; systemic
2.1
12.5
129
663
XG466
NOMESCO Finland
Sleep oxymetry
3.5
12.5
43
127
R95
ICPC
Chron obstructive pulmonary disease
3.0
12.3
56
196
R02
ICPC
Shortness of breath/dyspnoea
2.1
12.1
123
628
R03AC12
ATC
salmeterol; inhalant
2.5
11.9
79
337
R03AL09
ATC
formoterol, glycopyrronium bromide and beclometasone; inhalant
3.3
11.0
42
133
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.6
10.7
361
2646
XG405
NOMESCO Finland
Education on PEF monitoring
8.7
10.6
22
26
GX1K5
NOMESCO Finland
Diffusion capacity
23.7
10.3
14
6
R03BB02
ATC
oxitropium bromide; inhalant
4.0
10.1
28
71
R05DA20
ATC
opium alkaloids and derivatives - combinations
1.8
10.0
186
1161
GD1CD
NOMESCO Finland
Thorax extensive CT-examination
7.8
9.9
22
29
J45.0
ICD-10 Finland
Predominantly allergic asthma
2.7
9.8
55
216
Z01.8
ICD-10 Finland
Other specified special examinations
1.8
9.8
170
1039
4912A
ICD-9 Finland
Chronic bronchitis, Obstructive chronic bronchitis[BRONCHITIS CHRONICA OBSTRUCTIVA]
4.4
9.4
23
53
WX725
NOMESCO Finland
Noninvasive ventilation
2.7
8.8
47
180
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
1.8
8.8
158
972
356
Kela drug reimbursment
Nintedanib and pirfenidone
10.8
8.8
16
15
J01FA06
ATC
roxithromycin; oral
1.6
8.7
291
2102
J44
ICD-10 Finland
Other chronic obstructive pulmonary disease
3.0
8.6
38
131
Y96.0
ICD-10 Finland
Work-related condition
27.8
8.5
11
*
XG474
NOMESCO Finland
Exhalation nntrogen oxide
4.5
8.4
20
45
R03AL08
ATC
vilanterol, umeclidinium bromide and fluticasone furoate; inhalant
3.8
8.4
25
67
7931A
ICD-9 Finland
Nonspecific abnormal findings on radiological and other examination of body structure, Lung field
6.6
8.2
20
31
GAC00
NOMESCO Finland
Biopsy of pleura
8.2
8.1
17
21
GD5BD
NOMESCO Finland
Thorax and upper abdomen combined extensive CT examination of
3.2
8.0
31
99
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.5
7.9
320
2402
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.7
7.8
181
1193
L01
ICPC
Neck symptom/complaint
2.1
7.6
72
357
R99
ICPC
Respiratory disease other
3.5
7.6
25
72
8041/3-C34.9
ICD-O-3
Small cell carcinoma, NOS, of lung, NOS
4.2
7.6
20
49
N02AX02
ATC
tramadol; systemic, rectal
1.5
7.4
349
2694
J62.8
ICD-10 Finland
Pneumoconiosis due to other dust containing silica
+∞
7.3
7
*
J96.0
ICD-10 Finland
Acute respiratory failure
3.3
7.3
27
84
L01EX09
ATC
nintedanib; oral
15.9
7.2
11
7
5188X
ICD-9 Finland
Other diseases of lung
7.4
7.2
16
22
R03DC03
ATC
montelukast; oral
2.0
7.2
84
451
R05
ICPC
Cough
1.7
7.0
134
838
5119X
ICD-9 Finland
Pleurisy, Unspecified pleural effusion
5.5
6.9
19
35
TGW99
NOMESCO Finland
Other minor procedure in thoracic surgery
13.9
6.9
11
8
284
Kela drug reimbursment
Nintedanib and pirfenidone
8.4
6.8
14
17
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.2
6.7
55
258
J46
ICD-10 Finland
Status asthmaticus
3.4
6.6
23
69
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
1.7
6.5
137
877
GDC00
NOMESCO Finland
Lobectomy of lung
5.8
6.5
17
30
J01MA12
ATC
levofloxacin; systemic
1.6
6.5
192
1338
C03CA01
ATC
furosemide; systemic
1.4
6.4
420
3433
J62.0
ICD-10 Finland
Pneumoconiosis due to talc dust
+∞
6.3
6
*
ZX109
NOMESCO Finland
Instruction on medicine inhalation technique
7.1
6.2
14
20
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
5.6
6.0
16
29
J84.8
ICD-10 Finland
Other specified interstitial pulmonary diseases
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
121
538
2.45
16.77
7.6
3.9
5.49
5.13
kpa
3.41
113
503
116
508
2.48
16.61
7.4
3.9
2.50
1.85
mmol/l
1.02
94
362
81
306
2.82
15.56
8.9
4.3
25.88
24.55
mmol/l
2.86
74
278
78
299
2.77
14.57
3.3
2.8
—
—
—
0
0
25
54
4.74
11.00
3.6
3.3
—
—
—
0
0
47
169
2.88
9.90
1.8
1.6
—
—
—
0
0
151
910
1.80
9.05
6.4
6.5
5.22
5.03
kpa
1.34
143
861
151
910
1.80
9.05
6.4
6.5
10.22
11.38
kpa
2.54
143
859
104
566
1.95
8.54
1.3
1.2
23.15
44.83
iu/ml
2.60
31
168
24
62
3.95
8.46
1.2
1.8
—
—
—
0
0
24
62
3.95
8.46
1.2
1.8
—
—
—
0
0
24
62
3.95
8.46
1.2
1.8
—
—
—
0
0
33
106
3.20
8.45
2.1
1.7
—
—
—
0
0
33
106
3.20
8.45
2.1
1.7
—
—
—
0
0
43
161
2.76
8.44
1.9
1.6
—
—
—
0
0
147
910
1.74
7.98
6.5
6.6
1.82
1.18
mmol/l
1.24
115
687
118
699
1.80
7.43
5.2
4.9
33.99
32.89
%
0.40
74
464
317
2417
1.50
7.10
4.5
3.4
2254.92
2568.55
ng/l
0.59
286
2139
22
61
3.68
7.06
1.6
1.9
—
—
—
0
0
33
121
2.80
6.77
1.5
1.6
—
—
—
0
0
22
64
3.50
6.60
1.6
1.9
—
—
—
0
0
334
2613
1.46
6.40
6.6
5.5
23.07
23.86
%
0.65
309
2436
74
401
1.93
6.17
6.3
9.4
25.21
24.19
mmol/l
2.03
68
385
27
95
2.90
5.98
1.8
1.5
—
—
—
0
0
18
52
3.51
5.47
2.4
1.6
—
—
—
0
0
321
2550
1.41
5.45
6.1
5.3
60.29
60.18
%
0.05
294
2384
38
168
2.32
5.38
2.2
2.0
135.61
124.42
g/l
1.26
23
126
25
90
2.83
5.34
3.1
2.5
28.50
26.06
mg/l
—
6
17
183
1319
1.49
5.17
2.4
1.8
—
—
—
0
0
377
3105
1.38
5.07
7.5
8.0
4.98
4.58
e9/l
1.73
324
2690
58
312
1.92
4.97
2.2
1.8
—
—
—
0
0
25
94
2.71
4.95
1.2
1.5
—
—
—
0
0
151
1056
1.52
4.91
1.6
1.7
1.24
1.68
mg/l
1.34
110
849
23
85
2.75
4.71
3.4
3.3
—
—
—
0
0
15
35
4.34
4.64
1.2
2.0
—
—
—
0
0
15
35
4.34
4.64
1.2
2.0
—
—
—
0
0
13
26
5.06
4.64
1.0
1.1
—
—
—
0
0
26
104
2.55
4.58
1.2
1.1
—
—
—
0
0
61
347
1.82
4.42
2.5
1.9
—
—
—
0
0
24
95
2.57
4.33
1.8
1.5
—
—
—
0
0
83
521
1.66
4.27
1.3
1.2
13.89
16.17
u/ml
0.08
23
177
13
29
4.54
4.26
1.0
1.1
—
—
—
0
0
27
115
2.39
4.19
1.9
1.5
—
—
—
0
0
26
109
2.43
4.18
1.2
1.5
—
—
—
0
0
12
26
4.67
4.06
1.3
2.0
—
—
—
0
0
12
26
4.67
4.06
1.2
2.0
—
—
—
0
0
110
751
1.53
3.99
12.2
9.9
—
—
—
0
0
453
3940
1.32
3.87
5.9
3.9
17.79
15.83
mm/h
1.48
419
3568
25
107
2.38
3.86
1.3
1.5
—
—
—
0
0
21
83
2.57
3.82
1.1
1.1
6.37
2.05
u/ml
—
6
6
365
3122
1.30
3.38
6.1
6.1
15.07
13.72
umol/l
0.46
340
2956
18
71
2.57
3.31
2.8
1.5
—
—
—
0
0
18
71
2.57
3.31
2.8
1.5
—
—
—
0
0
11
28
3.97
3.29
1.4
2.0
—
—
—
0
0
35
186
1.92
3.19
2.1
1.5
—
—
—
0
0
19
79
2.44
3.15
2.2
1.5
—
—
—
0
0
23
106
2.20
3.05
9.0
5.0
1126.00
1489.29
iu/ml
—
5
17
103
735
1.46
3.04
3.1
2.5
6.85
6.62
ug/l
0.05
82
629
33
177
1.90
2.95
2.8
2.4
16.30
15.38
%
0.61
21
85
18
78
2.34
2.76
1.1
1.1
—
—
—
0
0
22
106
2.10
2.65
3.3
3.0
59.23
61.56
%
0.27
22
106
10
30
3.36
2.61
1.3
1.3
2.01
7.83
ug/l
—
5
10
21
102
2.09
2.49
2.9
2.5
5.64
4.94
e9/l
0.30
21
102
315
2732
1.24
2.39
6.8
4.6
64.19
68.48
ng/l
0.10
261
2218
332
2900
1.24
2.35
3.5
3.1
71.37
63.57
u/l
0.51
289
2621
58
391
1.52
2.30
1.7
1.8
0.60
2.63
ug/l
1.20
47
333
98
1270
0.74
2.07
3.1
3.2
2.50
2.45
mmol/l
4.14
88
1099
35
216
1.65
2.03
4.1
3.1
7.69
7.52
kpa
0.23
35
210
14
63
2.24
2.01
1.3
1.5
—
—
—
0
0
325
2886
1.20
1.86
7.1
6.3
1.20
1.20
mmol/l
0.56
288
2599
33
207
1.62
1.82
3.0
3.1
0.69
0.89
nmol/l
2.73
21
159
221
1896
1.22
1.80
3.6
3.2
7.40
7.61
mmol/l
0.36
180
1541
223
1917
1.22
1.78
2.6
2.1
207.17
284.48
u/l
0.61
203
1776
128
1037
1.28
1.73
2.9
2.8
20.01
22.36
%
1.23
102
893
134
1094
1.27
1.70
2.8
2.7
2.27
2.16
g/l
1.48
119
1010
10
40
2.52
1.67
2.1
2.6
—
—
—
0
0
88
684
1.32
1.63
1.7
2.4
67.43
65.78
g/l
1.31
74
615
12
56
2.16
1.61
1.3
1.5
—
—
—
0
0
195
1675
1.21
1.56
3.5
3.2
393.10
8921.12
umol/l
7.03
151
1401
384
3503
1.17
1.55
23.2
23.6
1.50
1.51
inr
0.07
115
987
7
27
2.61
1.51
1.1
1.3
—
—
—
0
0
6
21
2.87
1.50
2.5
1.5
—
—
—
0
0
9
38
2.38
1.46
1.0
1.3
—
—
—
0
0
27
172
1.59
1.44
1.3
1.4
—
—
—
0
0
27
172
1.59
1.44
1.3
1.4
—
—
—
0
0
143
1207
1.22
1.37
2.8
2.7
11.58
11.82
umol/l
0.16
124
1119
216
1897
1.19
1.35
3.8
3.3
352.20
276.30
mg/l
0.11
143
1332
0
38
0.00
1.34
0.0
1.2
—
—
—
0
0
61
464
1.34
1.34
1.6
1.5
—
—
—
0
0
15
83
1.82
1.32
1.4
1.5
12.00
14.15
u/l
1.25
15
78
313
3431
0.86
1.31
4.8
5.0
22.52
22.30
%
0.09
169
1855
62
476
1.33
1.29
4.0
4.6
99.28
116.31
ng/l
0.76
55
408
417
3869
1.15
1.28
5.9
4.9
4.40
2024.18
e6/l
—
5
97
211
1866
1.17
1.22
3.0
2.5
59.77
101.77
u/l
0.48
187
1729
386
4151
0.87
1.20
28.1
23.5
16.61
15.62
%
1.74
376
4052
112
935
1.23
1.20
2.4
3.4
244.56
245.37
u/l
0.03
104
875
108
904
1.22
1.14
2.3
1.8
—
—
—
0
0
466
4381
1.14
1.13
8.9
7.6
88.88
84.80
u/l
0.57
433
4082
22
143
1.55
1.12
1.5
1.5
300.13
245.84
ug/g
0.79
15
94
63
497
1.29
1.10
1.8
1.6
—
—
—
0
0
7
33
2.13
1.05
1.3
1.7
—
—
—
0
0
44
333
1.34
1.04
1.4
1.2
—
—
—
0
0
11
190
0.57
1.03
5.5
3.8
1.23
1.70
mmol/l
2.19
11
185
7
34
2.07
1.03
1.3
1.6
—
—
—
0
0
225
2026
1.15
1.02
4.4
3.9
13.31
12.65
mg/mmol
0.05
146
1387
173
1528
1.17
1.02
4.7
4.2
0.00
0.00
estimate
-0.00
52
464
218
1961
1.15
1.00
2.5
2.2
3.46
3.01
mg/l
1.30
174
1668
252
2292
1.14
0.99
3.1
2.9
182.30
186.88
ug/l
0.11
216
2058
343
3183
1.13
0.98
8.0
7.2
1.20
1.20
mmol/l
0.39
272
2657
0
30
0.00
0.97
0.0
3.2
—
92.97
—
0
30
13
77
1.70
0.95
3.6
3.0
—
—
—
0
0
11
185
0.59
0.95
4.5
3.9
20.23
31.96
mg/l
—
6
135
7
37
1.90
0.94
1.1
1.1
—
83.75
—
0
8
106
905
1.20
0.94
2.2
1.7
—
—
—
0
0
70
574
1.24
0.92
2.3
2.1
0.17
0.19
g/l
1.39
61
521
120
1042
1.18
0.88
2.3
2.2
1.80
1.72
%
0.35
101
917
217
1969
1.14
0.88
2.2
2.1
79.48
77.57
nmol/l
0.46
179
1668
21
144
1.47
0.88
1.0
1.1
43.10
134.01
iu/ml
—
8
48
8
44
1.83
0.86
1.1
1.5
—
—
—
0
0
6
34
1.77
0.76
1.7
1.2
19.50
23.28
%
—
6
25
0
28
0.00
0.76
0.0
1.9
—
58.83
—
0
23
9
54
1.67
0.74
1.2
1.1
—
—
—
0
0
9
56
1.61
0.72
1.0
1.0
—
—
—
0
0
11
69
1.60
0.68
1.0
1.3
—
109.77
—
0
14
11
69
1.60
0.68
1.4
1.3
49.80
69.11
%
—
5
47
11
69
1.60
0.68
1.3
1.5
—
—
—
0
0
17
119
1.44
0.67
1.0
1.1
—
—
—
0
0
5
92
0.54
0.67
1.4
1.4
5.80
563.54
e6/l
—
5
78
16
111
1.45
0.66
1.4
1.4
367.54
324.54
u/l
0.15
16
106
11
70
1.58
0.65
1.3
1.5
—
—
—
0
0
297
2790
1.10
0.65
5.2
5.0
32.65
33.72
g/l
2.51
259
2583
11
71
1.56
0.62
1.3
1.5
—
—
—
0
0
5
30
1.67
0.61
1.0
1.0
—
—
—
0
0
5
30
1.67
0.61
1.6
2.9
—
—
—
0
0
5
30
1.67
0.61
1.6
2.9
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.1
—
—
—
0
0
74
642
1.17
0.59
6.4
7.0
1.33
1.51
mmol/l
1.14
74
622
149
1357
1.12
0.59
5.4
4.2
255.97
331.13
ng/l
0.27
128
1221
11
72
1.53
0.59
1.3
1.5
—
—
—
0
0
99
1111
0.88
0.58
3.9
3.4
0.69
0.81
e6/l
0.21
55
707
0
23
0.00
0.58
0.0
1.8
—
8.76
—
0
14
86
758
1.15
0.57
3.5
3.1
219.52
290.97
ng/l
1.26
80
685
16
115
1.40
0.57
1.8
1.8
85.43
89.03
%
0.86
16
115
11
73
1.51
0.56
1.3
1.5
—
—
—
0
0
11
73
1.51
0.56
1.3
1.5
—
—
—
0
0
22
168
1.32
0.55
1.5
1.5
35.44
30.59
g/l
1.28
22
153
179
1654
1.10
0.55
2.0
1.8
1197.51
1153.32
nmol/l
0.28
118
1258
33
267
1.25
0.54
1.7
2.9
34.32
91.30
mg/l
0.71
28
225
14
99
1.42
0.54
1.1
1.1
—
—
—
0
0
9
61
1.48
0.54
1.3
1.2
—
—
—
0
0
11
74
1.49
0.53
1.1
1.1
—
—
—
0
0
10
66
1.52
0.52
1.0
1.1
1.63
1.69
g/l
—
10
58
6
40
1.50
0.51
1.0
1.1
—
—
—
0
0
18
135
1.34
0.51
1.6
1.4
415052.36
83544.62
e6/l
0.51
11
84
474
4900
0.93
0.51
5.8
5.3
2.29
2.34
mmol/l
0.62
401
4338
31
379
0.81
0.51
5.5
4.5
51.65
47.71
%
0.37
31
373
20
258
0.77
0.51
1.5
1.2
—
—
—
0
0
13
93
1.40
0.48
1.7
1.6
—
—
—
0
0
12
85
1.42
0.47
1.6
1.2
—
—
—
0
0
19
148
1.29
0.43
1.6
1.4
1143.71
1956.08
e6/l
1.02
14
106
5
31
1.62
0.43
1.6
2.5
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
104
1134
0.91
0.41
3.5
3.2
1.33
0.94
e6/l
0.64
59
725
464
4774
0.94
0.40
7.7
6.9
42.25
41.97
mmol/mol
0.26
387
4292
253
2655
0.93
0.40
2.8
2.9
—
—
—
0
0
224
2124
1.07
0.39
2.5
2.1
—
—
—
0
0
5
35
1.43
0.39
1.0
1.0
—
—
—
0
0
7
106
0.66
0.39
1.6
2.0
—
—
—
0
0
0
19
0.00
0.39
0.0
1.4
—
—
—
0
0
52
459
1.14
0.37
3.4
3.3
57.11
56.38
ml/min/173m2
0.05
27
209
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
460
4726
0.94
0.37
5.4
4.7
3.97
4.08
mmol/l
1.46
389
4226
55
488
1.14
0.37
2.8
2.4
36.46
35.59
u/l
0.07
48
402
9
71
1.27
0.36
1.2
1.4
—
—
—
0
0
539
5506
0.94
0.34
37.7
29.2
133.12
131.64
g/l
1.34
520
5356
539
5506
0.94
0.34
37.5
29.0
4.40
4.33
e12/l
1.91
510
5280
539
5505
0.94
0.34
37.5
29.2
40.05
38.78
%
4.49
482
4991
539
5505
0.94
0.34
37.5
29.0
230.01
222.41
e9/l
1.84
515
5304
172
1625
1.07
0.34
3.8
3.0
34.57
37.02
u/l
0.28
161
1552
11
83
1.33
0.32
1.5
1.2
—
—
—
0
0
455
4663
0.95
0.32
5.5
4.7
1.28
1.32
mmol/l
1.31
382
4111
7
100
0.70
0.30
1.7
1.3
—
—
—
0
0
7
55
1.27
0.30
1.6
1.3
—
—
—
0
0
7
55
1.27
0.30
1.6
1.3
—
—
—
0
0
81
747
1.09
0.29
8.3
6.9
13.05
12.76
mmol/l
0.12
74
706
196
2052
0.94
0.29
4.9
4.3
—
—
—
0
0
59
536
1.11
0.29
3.7
3.7
1.22
1.21
mmol/l
0.32
52
465
105
982
1.08
0.28
6.1
5.9
1.01
1.03
mmol/l
0.23
97
902
10
76
1.32
0.28
1.1
1.1
—
—
—
0
0
8
62
1.29
0.28
2.1
1.5
—
—
—
0
0
287
2775
1.05
0.27
2.2
2.2
93.48
89.44
pmol/l
0.65
158
1579
11
139
0.79
0.27
2.1
2.2
90.45
82.95
%
0.65
11
133
155
1477
1.06
0.25
2.3
2.6
—
—
—
0
0
47
426
1.11
0.25
2.3
2.1
373.65
373.41
nmol/l
0.00
40
378
9
76
1.19
0.24
1.6
1.1
—
—
—
0
0
61
562
1.09
0.24
2.1
2.2
9.66
11.01
nmol/l
0.71
50
474
230
2380
0.95
0.23
3.2
3.4
0.85
0.85
ug/l
0.04
170
1731
5
38
1.32
0.23
1.6
1.3
—
—
—
0
0
5
38
1.32
0.23
1.6
1.3
—
—
—
0
0
22
190
1.16
0.23
2.5
2.2
58.24
111.57
ug/min
—
10
117
376
3675
1.04
0.22
6.4
5.1
6.94
7.00
mmol/l
0.20
357
3498
524
5322
0.96
0.22
13.5
11.0
25.42
24.88
u/l
0.22
491
5041
13
107
1.22
0.21
2.2
2.3
63.19
61.62
%
0.07
13
107
0
10
0.00
0.21
0.0
2.9
—
102.11
—
0
10
0
10
0.00
0.21
0.0
1.3
—
96.36
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
463
4712
0.96
0.21
23.5
19.4
66.77
67.53
ml/min/173m2
0.34
400
3981
484
4920
0.96
0.21
6.0
5.2
6.22
6.23
mmol/l
0.08
405
4303
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
527
5191
1.04
0.21
27.1
20.0
27.68
31.80
mg/l
1.94
465
4406
441
4490
0.96
0.20
4.7
4.0
2.20
2.13
mu/l
0.34
375
3911
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
539
5465
0.96
0.20
31.3
24.4
4.09
4.06
mmol/l
2.03
516
5287
269
2619
1.04
0.19
4.5
4.0
0.00
0.00
estimate
0.80
69
568
539
5463
0.96
0.19
31.3
24.2
139.31
139.58
mmol/l
1.50
518
5284
14
119
1.18
0.17
1.8
1.2
—
—
—
0
0
14
119
1.18
0.17
1.8
1.2
—
—
—
0
0
7
61
1.15
0.17
1.0
1.2
—
—
u/ml
—
0
0
20
226
0.88
0.17
1.6
1.6
—
—
—
0
0
110
1053
1.05
0.17
4.3
3.0
0.81
0.82
mmol/l
0.51
102
972
150
1554
0.96
0.17
1.7
1.8
429.92
4488596.00
pmol/l
0.50
105
1270
6
77
0.78
0.15
6.7
3.4
310.00
331.52
umol/l
—
6
65
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
37
342
1.09
0.15
2.2
2.5
0.31
0.34
u/ml
0.23
18
195
14
121
1.16
0.15
1.2
1.3
1.14
1.09
g/l
0.27
14
116
23
207
1.11
0.15
1.8
1.6
—
—
—
0
0
70
737
0.95
0.15
2.5
3.9
18.10
42.40
ug/l
0.81
58
612
173
1774
0.97
0.12
1.8
1.7
19.07
18.85
nmol/l
0.07
146
1513
78
748
1.05
0.12
5.2
4.0
—
—
—
0
0
200
2043
0.97
0.11
3.1
3.3
2.34
2.32
mmol/l
0.94
169
1767
29
270
1.08
0.10
2.2
2.7
1.50
1.65
g/l
0.06
23
232
53
505
1.05
0.10
1.6
1.7
—
—
—
0
0
5
46
1.09
0.09
1.0
1.1
—
—
—
0
0
114
1171
0.97
0.09
1.8
1.6
1.32
1.24
mmol/l
0.30
90
944
13
116
1.12
0.09
1.2
1.5
7.22
6.48
mmol/l
0.35
13
110
65
675
0.96
0.09
2.8
2.6
18.49
11.43
umol/l
0.71
60
601
18
165
1.09
0.08
1.4
1.3
—
—
—
0
0
32
302
1.06
0.08
2.2
2.5
3.01
2.98
g/l
0.11
27
266
11
98
1.12
0.07
3.7
6.3
11.09
12.34
mg/l
0.52
11
93
244
2473
0.98
0.07
4.8
3.6
—
—
—
0
0
209
2121
0.98
0.07
4.5
3.7
314.80
132.87
e6/l
0.34
163
1740
29
306
0.95
0.07
2.2
2.6
11.99
11.26
g/l
0.34
24
268
9
102
0.88
0.06
1.0
1.1
—
14.12
—
0
5
423
4260
0.99
0.06
6.0
5.8
5.99
5.12
ug/l
0.13
344
3722
266
2632
1.02
0.06
4.6
4.0
0.00
0.00
estimate
-0.00
65
499
14
129
1.09
0.05
1.9
1.2
—
—
—
0
0
117
1191
0.98
0.05
5.1
4.5
1.01
1.02
kg/l
1.28
21
214
260
2575
1.01
0.05
5.7
5.3
0.00
0.00
estimate
-0.00
66
518
451
4536
0.99
0.05
4.8
4.2
1.25
1.22
mmol/l
0.38
378
3970
42
434
0.97
0.05
1.6
1.7
1.62
1.46
g/l
0.59
34
369
228
2302
0.99
0.04
5.2
4.1
262.31
124.38
e6/l
0.42
165
1819
76
749
1.02
0.02
1.2
1.1
1.52
1.83
u/ml
0.17
16
163
32
329
0.97
0.02
2.2
2.5
3.87
3.67
g/l
0.39
27
292
340
3414
0.99
0.02
3.9
3.1
15.39
15.11
pmol/l
1.00
290
2959
155
1540
1.01
0.01
3.9
2.7
3.10
3.26
e6/l
0.12
141
1388
187
1878
0.99
0.01
4.5
3.6
0.50
0.53
e6/l
0.07
142
1531
12
116
1.03
0.00
1.0
1.3
—
—
—
0
0
13
126
1.03
0.00
1.4
1.4
—
—
—
0
0
14
136
1.03
0.00
1.2
1.6
—
—
—
0
0
37
375
0.99
0.00
1.5
1.6
1.52
1.82
%
2.72
27
287
72
722
1.00
0.00
3.9
3.9
3.21
1.78
mmol/l
2.55
62
574
33
329
1.00
0.00
2.1
2.5
7.88
7.31
g/l
1.16
28
293
33
329
1.00
0.00
2.1
2.5
—
—
—
0
0
25
245
1.02
0.00
2.1
2.5
36.30
36.66
g/l
0.14
20
210
0
8
0.00
0.00
0.0
1.0
—
1849.50
—
0
8
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
8.90
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.3
—
39.83
—
0
6
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
9
99
0.91
-0.00
1.2
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.0
—
13.22
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.5
3.28
5.49
mg/l
—
5
46
0
6
0.00
-0.00
0.0
2.2
—
0.17
—
0
6
Mortality – FinRegistry
↥Association
Association between endpoint J10_ASBESTPNEUMOC and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.687 [1.26, 2.25] | < 0.001 |
| Birth year | 0.998 [0.99, 1.01] | 0.642 |
During the follow-up period (1.1.1998 — 31.12.2019), 117 out of 200 females with J10_ASBESTPNEUMOC died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| J10_ASBESTPNEUMOC | 1.879 [1.69, 2.09] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 2029 out of 3332 males with J10_ASBESTPNEUMOC died.
Mortality risk
Mortality risk for people of age
years, who have J10_ASBESTPNEUMOC.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.176% | 0.358% |
| 5 | 1.034% | 2.316% |
| 10 | 2.786% | 5.423% |
| 15 | 5.368% | 10.024% |
| 20 | 9.573% | 16.505% |
Relationships between endpoints
↥Index endpoint: J10_ASBESTPNEUMOC – Pneumoconiosis due to asbestos and other mineral fibres
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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