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Granuloma annulare

DOID EFO Endpoint Browser PheWeb

L12_GRANUANNU

granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).

Suggest a new description

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — L92.0
  • Hospital discharge: ICD-9 — 7098A
  • Cause of death: ICD-10 — L92.0
  • Cause of death: ICD-9 — 7098A

2 out of 7 registries used, show all original rules.

534

4. Check minimum number of events

None

534

5. Include endpoints

None

534

6. Filter based on genotype QC (FinnGen only)

534

Control definitions (FinnGen only)

Control exclude
L12_OTHERSKINSUBCUTIS

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
L92
Name in latin
Granuloma anulare

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 3343 2530 797
Only index persons 3180 2436 744
Unadjusted period prevalence (%)
Whole population 0.06 0.07 0.02
Only index persons 0.08 0.09 0.03
Median age at first event (years)
Whole population 50.83 50.97 50.58
Only index persons 51.04 51.08 50.91

-FinnGen-

Key figures

All Female Male
Number of individuals 534 428 106
Unadjusted period prevalence (%) 0.13 0.15 0.05
Median age at first event (years) 53.70 51.46 62.76

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
472
Matched controls
4719
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.0
ICD-10 Finland
Granuloma annulare
4503599627370496.0
323.0
468
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
26.1
144.3
212
143
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.5
51.6
185
493
D07AC01
ATC
betamethasone; topical
3.7
38.3
246
1073
D07AD01
ATC
clobetasol; topical
4.0
27.8
127
395
D07AC13
ATC
mometasone; topical
3.0
24.8
185
829
XQ848
NOMESCO Finland
Dermatological photography
16.9
24.6
39
25
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
7.6
21.4
51
74
E0000UV
ATC
NA
2.5
20.3
234
1318
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
36.5
16.8
21
6
TQW80
NOMESCO Finland
Local dermatologic skincare
14.1
16.7
28
21
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
+∞
14.7
14
*
P01BA02
ATC
hydroxychloroquine; oral
3.7
13.4
61
183
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
+∞
12.6
12
*
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
5.2
12.0
37
76
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.9
11.8
49
136
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
13.1
11.2
19
15
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
3.7
11.0
49
145
A10AE04
ATC
insulin glargine; parenteral
3.2
10.6
57
195
J04BA02
ATC
dapsone; oral
33.3
10.4
13
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.2
9.7
113
594
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.0
9.6
30
63
A10AE05
ATC
insulin detemir; parenteral
3.8
9.6
40
112
103
Kela drug reimbursment
Diabetes, insulin-treated
2.1
9.5
117
629
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
9.4
9
*
D02AE01
ATC
carbamide; topical
3.3
8.4
41
131
T89
ICPC
Diabetes insulin dependent
4.6
8.4
28
64
D07AB02
ATC
hydrocortisone butyrate; topical
1.9
8.3
142
865
SPAT1153
SPAT
Removal of sutures
1.8
7.6
150
953
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
10.3
7.6
14
14
S29
ICPC
Skin symptom/complaint other
2.1
7.5
89
469
XQ845
NOMESCO Finland
Dermatoscopy
13.6
7.4
12
9
WXQ27
NOMESCO Finland
UVB narrow spectrum light therapy
11.1
7.3
13
12
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
7.3
88
466
L92.8
ICD-10 Finland
Other granulomatous disorders of skin and subcutaneous tissue
+∞
7.3
7
*
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.8
7.3
23
50
J02AC01
ATC
fluconazole; systemic
1.7
7.2
215
1552
E000001
ATC
NA
2.0
7.2
105
597
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
20.4
7.2
10
5
UJF32
NOMESCO Finland
Coloscopy
1.9
7.1
119
714
G56.0
ICD-10 Finland
Carpal tunnel syndrome
2.2
7.1
74
367
N02BE01
ATC
paracetamol; systemic, rectal
2.0
6.9
403
3535
J01DA01
ATC
[U] cefalexin; systemic
1.7
6.7
300
2412
D07AB08
ATC
desonide; topical
2.4
6.6
55
245
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
4.7
6.4
20
44
H02AB06
ATC
prednisolone; systemic
1.6
6.3
209
1535
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
+∞
6.3
6
*
E000002
ATC
NA
2.3
6.3
58
274
L43.8
ICD-10 Finland
Other lichen planus
5.2
6.2
18
36
D01AE15
ATC
terbinafine; topical
2.9
6.2
36
131
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
4.1
6.1
22
56
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
2.9
6.1
35
127

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
148
148
13.45
137.43
1.3
1.2
—
—
—
0
0
130
598
2.55
17.56
1.4
1.4
309.6
544.1
titre
2.08
27
128
234
1402
2.19
17.03
6.3
5.3
—
—
—
0
0
317
2170
2.13
16.00
6.2
5.3
0.0
0.0
e9/l
1.47
274
1882
316
2161
2.13
15.99
6.2
5.3
0.6
0.6
e9/l
0.44
274
1872
324
2250
2.12
15.57
6.3
5.7
0.2
0.2
e9/l
0.38
285
1987
322
2233
2.11
15.51
6.2
5.4
1.9
2.0
e9/l
0.50
282
1977
291
1953
2.08
15.19
6.7
5.5
0.8
0.7
%
1.80
279
1817
297
2044
2.02
14.06
6.7
5.3
3.0
2.8
%
0.61
284
1896
298
2057
2.02
13.95
6.9
5.6
8.5
8.3
%
0.58
287
1927
301
2118
1.97
12.97
6.7
5.4
28.6
28.9
%
0.20
287
1975
269
1839
1.93
12.45
2.3
2.0
—
—
—
0
0
342
2534
1.97
12.44
8.8
8.6
4.0
4.0
e9/l
0.01
300
2217
196
1210
1.98
12.22
5.1
4.0
12.1
10.1
mg/mmol
0.23
109
711
296
2098
1.92
12.19
6.5
5.2
56.5
56.8
%
0.14
283
1967
203
1273
1.96
12.06
3.8
3.1
6.8
7.2
mmol/l
0.67
165
1069
186
1145
1.96
11.57
4.0
3.2
892.5
248.1
mg/l
0.57
108
689
417
3375
2.08
11.01
5.0
3.9
12.8
11.3
mm/h
1.39
396
3120
251
1753
1.81
10.21
5.3
4.2
35.8
35.9
g/l
0.11
229
1641
241
1681
1.79
9.70
2.2
1.9
100.1
97.2
pmol/l
0.36
131
846
414
3401
1.97
9.65
8.6
6.7
77.4
77.1
u/l
0.06
396
3170
143
850
1.93
9.60
1.3
1.3
18.0
31.6
iu/ml
2.01
45
275
282
2067
1.77
9.51
7.1
6.0
1.2
1.2
mmol/l
0.09
237
1738
137
824
1.89
8.78
1.3
1.3
5.2
12.7
u/ml
1.18
55
315
202
1381
1.74
8.42
2.6
2.3
55.7
57.0
u/l
0.23
185
1270
171
1127
1.76
8.03
1.5
1.3
2.3
2.3
u/ml
0.01
49
313
20
48
4.29
7.80
1.3
1.3
—
—
—
0
0
293
2252
1.67
7.67
6.4
5.6
11.5
10.4
umol/l
0.46
275
2124
314
2467
1.66
7.46
5.0
4.2
7.0
6.5
mmol/l
2.44
291
2268
252
1876
1.65
7.37
6.0
5.5
1.2
1.2
mmol/l
0.09
229
1696
481
4291
2.22
7.24
6.1
4.8
1.9
1.8
mu/l
0.15
448
3939
215
1549
1.65
7.08
11.9
7.5
1.2
1.2
inr
0.40
67
485
501
4565
2.58
6.85
18.5
13.4
139.4
139.7
mmol/l
2.03
489
4433
17
40
4.36
6.79
1.4
1.5
—
—
—
0
0
501
4577
2.53
6.59
18.6
13.5
4.0
3.9
mmol/l
1.65
488
4432
423
3652
1.76
6.53
5.1
4.1
14.8
14.7
pmol/l
0.71
395
3320
495
4503
2.36
6.50
17.3
12.0
19.9
21.0
mg/l
0.32
425
3470
198
1463
1.56
5.56
3.0
3.1
2.4
2.4
mmol/l
0.36
168
1287
72
406
1.89
5.49
2.2
1.9
386.2
377.2
nmol/l
0.16
65
378
78
457
1.83
5.28
1.9
1.4
—
—
—
0
0
172
1250
1.55
5.12
4.4
3.7
7.4
7.4
ph
0.68
35
234
452
4058
1.74
5.09
7.1
5.2
41.9
39.0
mmol/mol
5.28
424
3767
81
494
1.75
4.79
6.8
4.9
1.1
1.1
mmol/l
0.82
76
449
84
519
1.73
4.75
1.8
1.3
—
—
—
0
0
167
1224
1.53
4.72
2.5
2.0
143.8
217.0
u/l
0.71
162
1158
141
1001
1.56
4.59
5.4
3.9
—
—
—
0
0
510
4793
2.43
4.57
13.1
9.5
25.9
24.3
u/l
1.39
495
4619
53
289
1.93
4.48
2.5
2.6
74.0
73.4
e9/l
0.03
39
219
147
1066
1.52
4.31
3.1
2.5
354.5
6982.4
umol/l
4.85
128
927
74
457
1.72
4.19
22.1
18.2
1.4
1.2
inr
0.57
16
64
140
1012
1.52
4.15
4.8
4.4
—
—
—
0
0
258
2104
1.44
4.12
3.2
2.7
105.0
90.8
ug/l
0.50
241
1941
107
731
1.58
4.08
3.7
3.4
300.1
337.2
ng/l
0.09
75
514
197
1531
1.45
4.06
3.8
3.3
36.7
36.0
ng/l
0.02
126
978
105
716
1.58
4.03
1.8
1.7
1321.6
1222.3
nmol/l
0.61
82
532
135
974
1.52
4.03
1.5
1.5
2.3
2.3
g/l
0.05
72
585
59
347
1.79
3.95
5.0
4.1
0.9
0.9
%
0.00
19
97
54
313
1.81
3.80
5.2
3.8
0.8
0.7
%
0.11
13
64
18
66
2.79
3.79
1.1
1.1
154.8
26.3
iu/ml
—
5
10
470
4347
1.68
3.72
5.0
4.3
6.2
5.8
mmol/l
4.61
430
3985
358
3131
1.44
3.71
5.4
4.1
—
—
—
0
0
144
1073
1.47
3.63
2.5
2.0
2.9
3.0
mg/l
0.19
133
907
133
976
1.48
3.62
1.6
1.5
20.1
21.1
nmol/l
0.34
114
828
55
326
1.77
3.60
5.2
4.2
0.1
0.1
%
0.16
17
84
53
311
1.78
3.59
1.8
3.1
68.4
67.3
g/l
0.66
46
281
19
74
2.63
3.59
1.3
1.4
268.5
250.3
u/ml
—
8
45
63
389
1.70
3.57
1.3
1.1
—
—
—
0
0
81
535
1.61
3.55
2.9
2.3
21.6
22.3
%
0.18
69
462
53
313
1.77
3.51
5.1
4.3
0.1
0.0
%
0.36
13
72
52
307
1.77
3.45
2.3
2.7
10.7
10.4
g/l
0.30
47
283
13
42
3.15
3.39
2.5
2.0
—
—
—
0
0
158
1213
1.43
3.38
1.8
1.7
1.3
1.4
mmol/l
0.59
126
1030
523
5037
2.86
3.23
25.3
18.1
257.3
257.1
e9/l
0.02
517
4919
523
5040
2.83
3.17
25.2
18.1
4.4
4.5
e12/l
0.91
514
4913
90
626
1.53
3.15
2.7
2.2
13.1
13.3
umol/l
0.10
85
571
523
5042
2.81
3.13
25.3
18.1
6.6
6.6
e9/l
0.04
515
4909
50
301
1.73
3.12
1.5
1.5
—
—
—
0
0
269
2281
1.36
3.11
3.8
3.5
0.0
0.0
estimate
0.50
44
436
264
2237
1.36
3.04
3.8
3.5
0.0
0.0
estimate
0.00
46
449
343
3036
1.36
2.93
4.1
3.4
—
—
—
0
0
89
631
1.49
2.85
3.3
3.0
0.8
0.8
mmol/l
0.24
83
595
42
248
1.75
2.82
3.8
3.9
7.4
7.4
ph
—
7
25
264
2255
1.34
2.81
4.9
4.7
0.0
0.0
estimate
0.50
48
448
66
440
1.57
2.79
6.8
5.8
105.0
104.2
mmol/l
0.89
66
429
50
311
1.67
2.79
3.9
3.8
84.8
76.7
ng/l
0.29
43
276
85
604
1.48
2.69
2.1
2.2
112.0
112.0
ug/g
0.00
61
466
48
299
1.67
2.67
1.8
2.5
4.1
4.0
e9/l
0.16
37
241
134
1038
1.39
2.66
3.7
3.4
—
—
—
0
0
36
207
1.79
2.65
1.1
1.1
—
—
—
0
0
70
484
1.51
2.53
2.4
2.5
8.4
7.1
umol/l
0.17
60
402
42
257
1.69
2.51
2.0
2.6
—
—
—
0
0
41
250
1.69
2.48
1.2
1.2
—
—
—
0
0
36
212
1.75
2.46
2.9
2.3
—
—
—
0
0
51
330
1.60
2.46
2.7
3.7
2.4
2.1
mmol/l
0.38
38
256
236
2013
1.31
2.43
11.0
8.6
0.0
0.0
e9/l
0.64
190
1655
104
784
1.41
2.41
2.6
2.7
2.5
2.4
mmol/l
0.60
87
691
23
119
1.97
2.34
1.1
1.4
320.8
325.9
ug/g
0.05
13
71
497
4754
1.66
2.32
16.5
11.5
—
—
—
0
0
72
512
1.47
2.28
1.4
1.3
—
—
—
0
0
170
1396
1.32
2.27
3.2
2.7
—
—
—
0
0
138
1104
1.34
2.20
6.8
6.4
—
—
—
0
0
114
887
1.36
2.18
1.9
1.6
126596168.9
16378603.2
pmol/l
0.41
94
751
78
569
1.43
2.17
2.1
1.8
—
—
—
0
0
77
563
1.43
2.12
1.2
1.2
—
—
—
0
0
14
62
2.29
2.09
3.4
2.3
—
—
—
0
0
7
20
3.53
2.06
2.9
3.8
—
—
—
0
0
17
83
2.08
2.03
3.4
2.0
130.7
131.0
g/l
0.01
11
55
17
83
2.08
2.03
4.6
3.7
53.0
56.3
%
0.51
17
83
28
459
0.59
2.03
1.2
1.3
—
—
—
0
0
14
63
2.26
2.02
1.1
1.5
—
—
—
0
0
71
519
1.42
1.96
1.6
1.5
—
—
—
0
0
6
16
3.78
1.94
1.3
1.6
148.7
144.4
nmol/l
—
6
16
9
33
2.76
1.94
1.2
1.2
—
—
—
0
0
121
968
1.32
1.92
1.8
1.9
—
—
—
0
0
17
316
0.52
1.91
1.5
1.4
—
—
—
0
0
26
151
1.76
1.90
4.1
5.4
0.9
0.9
%
0.37
26
142
52
362
1.48
1.86
1.7
1.4
—
—
—
0
0
58
414
1.45
1.83
3.3
3.9
9.0
18.2
ug/l
0.36
48
341
243
2135
1.25
1.83
4.7
3.9
—
—
—
0
0
25
148
1.72
1.73
1.4
1.3
—
—
—
0
0
36
235
1.57
1.73
5.4
5.0
—
—
—
0
0
43
293
1.51
1.71
3.3
2.6
—
—
—
0
0
465
4436
1.37
1.68
5.1
4.2
4.6
4.8
mmol/l
2.13
440
4111
8
31
2.60
1.66
1.1
1.3
—
—
—
0
0
447
4242
1.33
1.65
4.5
3.7
1.3
1.2
mmol/l
1.56
411
3897
7
25
2.82
1.65
2.9
3.2
—
—
—
0
0
56
406
1.42
1.64
4.2
4.0
—
—
—
0
0
25
151
1.69
1.63
3.8
3.8
0.4
0.3
g/l
—
9
50
6
20
3.02
1.58
1.7
1.7
—
—
—
0
0
8
33
2.45
1.54
1.5
1.4
—
—
—
0
0
8
33
2.45
1.54
3.6
2.8
—
—
—
0
0
470
4504
1.36
1.54
5.6
4.6
2.7
2.8
mmol/l
1.44
428
4159
25
154
1.65
1.53
4.2
5.3
1.8
1.5
%
0.84
25
145
7
27
2.61
1.52
1.0
1.1
—
—
—
0
0
79
623
1.31
1.40
1.4
1.2
—
—
—
0
0
7
29
2.43
1.39
1.6
1.2
24.9
9.2
u/l
—
7
23
12
60
2.02
1.39
1.5
1.6
—
—
—
0
0
15
82
1.85
1.37
4.3
3.6
3.5
4.1
e9/l
0.71
15
82
436
4152
1.27
1.36
18.0
12.9
38.9
39.6
%
0.91
307
3102
44
317
1.42
1.36
1.3
1.2
—
—
—
0
0
5
17
2.96
1.36
1.4
3.1
30.6
32.5
umol/l
—
5
17
47
343
1.41
1.36
5.6
3.7
1.2
1.2
mmol/l
0.05
39
292
460
4412
1.31
1.34
5.0
4.1
1.5
1.5
mmol/l
2.30
423
4072
10
47
2.15
1.34
1.5
1.7
—
—
—
0
0
177
1548
1.21
1.30
4.4
3.6
46.3
90.5
e6/l
1.35
108
1072
161
1395
1.22
1.30
2.6
2.1
—
—
—
0
0
11
55
2.02
1.28
2.5
1.6
1.3
1.5
mmol/l
0.60
11
55
9
44
2.06
1.27
1.9
1.6
31.6
32.5
pg
—
9
44
6
25
2.42
1.24
1.5
1.9
10.6
11.6
umol/l
—
6
25
28
189
1.51
1.21
3.2
4.1
—
—
—
0
0
8
38
2.12
1.19
2.3
1.2
—
—
—
0
0
137
1180
1.22
1.17
3.6
2.9
0.2
0.4
e6/l
1.75
87
874
12
65
1.87
1.14
1.3
1.1
—
—
—
0
0
14
81
1.75
1.10
5.4
8.1
9.1
10.8
mmol/l
1.74
14
74
14
81
1.75
1.10
5.4
8.1
104.5
105.5
mmol/l
0.27
14
74
8
41
1.97
1.09
1.3
1.1
—
—
—
0
0
135
1170
1.21
1.08
3.5
2.9
—
—
—
0
0
28
195
1.46
1.07
9.3
9.4
—
—
—
0
0
34
246
1.41
1.06
2.0
2.2
7086.1
5408.3
u/l
—
10
111
7
33
2.14
1.06
6.0
1.9
—
1.7
—
0
5
96
807
1.23
1.04
1.6
1.7
—
—
—
0
0
5
107
0.46
1.02
2.0
3.6
—
—
—
0
0
38
284
1.36
1.00
7.2
8.4
—
—
—
0
0
0
29
0.00
0.98
0.0
13.3
—
907.1
—
0
29
0
30
0.00
0.97
0.0
18.2
—
1671.3
—
0
30
7
36
1.96
0.97
1.0
1.0
—
—
—
0
0
137
1203
1.19
0.95
4.1
3.5
—
—
—
0
0
42
323
1.33
0.93
1.4
1.4
—
—
—
0
0
9
52
1.74
0.92
3.4
2.3
—
—
—
0
0
11
183
0.59
0.92
1.1
1.1
—
—
—
0
0
10
55
1.83
0.92
2.0
1.5
—
—
—
0
0
10
55
1.83
0.92
1.1
1.3
—
—
—
0
0
113
979
1.20
0.91
3.8
3.7
1.0
1.0
kg/l
0.82
21
129
142
1256
1.18
0.90
3.3
3.1
—
—
—
0
0
11
63
1.76
0.90
1.3
1.0
—
—
—
0
0
146
1295
1.18
0.90
3.7
3.0
41.0
64.4
e6/l
0.49
99
984
12
193
0.61
0.89
1.2
1.5
—
—
—
0
0
10
56
1.80
0.88
2.4
2.9
5.3
79.9
u/ml
—
10
51
402
3852
1.18
0.87
20.7
14.9
13.7
13.6
%
0.66
396
3781
120
1054
1.18
0.83
2.6
2.1
—
—
—
0
0
47
374
1.28
0.83
1.2
1.2
72.7
154.9
iu/ml
2.56
23
159
29
215
1.37
0.82
2.6
1.7
—
—
—
0
0
46
366
1.28
0.82
8.6
7.6
96.7
96.0
%
0.89
46
355
17
114
1.51
0.80
3.2
2.9
—
—
—
0
0
30
226
1.35
0.78
10.1
7.2
25.3
24.7
mmol/l
0.44
30
213
0
28
0.00
0.76
0.0
1.0
—
—
—
0
0
13
195
0.66
0.74
1.6
1.5
—
—
—
0
0
12
76
1.59
0.72
6.1
2.4
—
—
—
0
0
12
182
0.65
0.72
1.7
1.5
—
—
—
0
0
7
40
1.76
0.71
1.7
2.5
—
—
—
0
0
13
193
0.67
0.71
1.6
1.5
—
—
—
0
0
13
193
0.67
0.71
1.6
1.5
—
—
—
0
0
10
157
0.63
0.70
1.7
1.5
—
—
—
0
0
13
85
1.54
0.69
1.6
1.5
—
—
—
0
0
24
180
1.35
0.66
1.4
1.4
161.8
260.6
miu/ml
0.60
13
89
7
44
1.60
0.65
2.3
2.2
—
—
—
0
0
153
1669
0.88
0.63
3.2
2.7
—
—
—
0
0
18
130
1.40
0.62
2.6
1.8
2.9
5.1
iu/l
1.10
11
48
10
152
0.65
0.62
1.2
1.4
—
—
—
0
0
5
30
1.67
0.61
1.0
1.1
—
—
—
0
0
8
51
1.58
0.60
1.1
1.2
—
—
—
0
0
10
151
0.66
0.60
1.2
1.4
—
—
—
0
0
18
131
1.39
0.60
7.5
4.8
—
—
—
0
0
11
72
1.54
0.59
9.5
2.9
—
—
—
0
0
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
64
554
1.18
0.55
1.7
1.9
—
—
—
0
0
6
37
1.63
0.55
1.2
1.3
—
—
—
0
0
6
38
1.59
0.54
1.3
1.8
15.5
23.4
ug/l
—
6
38
11
157
0.69
0.52
1.2
1.5
—
—
—
0
0
48
408
1.19
0.52
8.4
7.4
5.0
5.1
kpa
0.54
48
396
48
408
1.19
0.52
8.3
7.4
12.7
12.3
kpa
0.29
48
395
9
64
1.41
0.51
1.1
1.1
—
—
—
0
0
9
65
1.39
0.51
1.7
1.7
—
—
—
0
0
6
41
1.47
0.50
1.7
2.8
—
—
—
0
0
48
411
1.18
0.48
8.3
7.3
1.8
1.3
mmol/l
0.53
42
334
7
47
1.50
0.47
1.1
1.3
—
—
—
0
0
7
47
1.50
0.47
1.1
1.3
—
—
—
0
0
7
47
1.50
0.47
1.1
1.3
—
—
—
0
0
7
47
1.50
0.47
1.1
1.3
—
—
—
0
0
99
897
1.13
0.47
3.3
2.4
4.1
6.2
e6/l
1.60
78
798
134
1237
1.11
0.47
4.7
3.7
0.0
0.0
estimate
0.69
43
450
7
49
1.43
0.46
2.3
1.9
89.8
90.2
%
—
7
49
21
165
1.28
0.45
1.5
1.6
—
—
—
0
0
9
130
0.69
0.43
1.8
1.9
—
—
—
0
0
12
87
1.39
0.42
1.3
1.3
—
—
—
0
0
12
87
1.39
0.42
1.1
1.9
—
—
—
0
0
5
32
1.57
0.42
3.4
1.0
279.2
299.2
mg/l
—
5
27
5
33
1.52
0.41
1.2
1.1
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
5
34
1.47
0.40
1.4
1.2
—
—
—
0
0
114
1054
1.10
0.39
3.2
1.7
1.4
1.1
mg/l
0.43
88
811
14
109
1.29
0.33
4.1
2.0
—
—
—
0
0
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
6
46
1.31
0.33
1.5
1.2
—
—
—
0
0
6
90
0.66
0.33
1.0
1.6
—
—
—
0
0
10
74
1.36
0.32
1.7
1.8
—
—
—
0
0
7
52
1.35
0.31
1.6
1.3
—
—
—
0
0
15
120
1.26
0.30
3.0
4.3
79.6
58.0
mg/l
—
10
93
15
120
1.26
0.30
3.0
4.3
20.2
27.1
mg/l
—
10
92
7
57
1.23
0.29
3.1
2.4
—
—
—
0
0
39
347
1.13
0.27
3.9
3.0
—
—
—
0
0
8
65
1.23
0.27
1.3
1.2
—
—
—
0
0
5
72
0.69
0.26
1.6
1.2
52.2
65.5
mmol/l
—
5
65
7
91
0.77
0.22
1.0
1.1
—
—
—
0
0
17
144
1.19
0.22
8.8
9.3
—
—
—
0
0
5
41
1.22
0.22
5.6
3.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
403.4
—
0
5
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
2.0
—
19.3
—
0
10
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
64
596
1.08
0.21
1.4
1.7
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
12
145
0.82
0.21
1.7
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
46.0
—
0
8
6
49
1.23
0.20
1.5
1.1
—
—
—
0
0
37
404
0.91
0.18
3.5
2.9
0.8
0.8
ug/l
0.19
27
267
12
100
1.20
0.18
2.3
4.1
45.4
32.1
mg/l
—
5
62
71
672
1.07
0.16
4.9
4.8
2.0
2.8
ug/l
0.78
60
599
44
409
1.08
0.16
5.4
3.6
—
—
—
0
0
6
79
0.76
0.15
3.2
2.8
—
—
—
0
0
10
83
1.21
0.15
1.4
1.3
—
—
—
0
0
9
81
1.11
0.15
1.1
1.2
—
—
—
0
0
11
93
1.19
0.14
2.9
4.8
—
—
—
0
0
12
103
1.17
0.14
1.3
1.1
0.9
2.5
e6/l
—
7
85
12
103
1.17
0.14
1.3
1.2
3.9
84.2
e6/l
—
7
88
11
94
1.17
0.13
1.0
1.1
—
—
—
0
0
139
1357
1.03
0.10
1.6
1.5
—
—
—
0
0
48
503
0.95
0.09
1.3
1.4
—
—
—
0
0
12
107
1.12
0.08
9.1
3.9
3.9
3.8
mmol/l
0.20
12
96
5
61
0.82
0.08
1.2
1.3
—
—
—
0
0
5
60
0.83
0.08
1.4
1.1
—
—
—
0
0
29
276
1.05
0.06
1.7
1.7
—
—
—
0
0
18
168
1.07
0.06
2.7
2.8
0.7
0.7
%
0.04
18
161
83
842
0.98
0.03
3.7
2.5
488.1
543.4
mosm/kgh2o
1.59
67
724
12
126
0.95
0.00
1.1
1.2
—
—
—
0
0
12
125
0.96
0.00
1.0
1.3
6.1
10.0
u/l
—
7
100
15
145
1.04
0.00
1.2
1.2
—
—
—
0
0
13
134
0.97
0.00
1.4
2.7
—
—
—
0
0
14
137
1.02
0.00
1.1
1.1
—
—
—
0
0
21
213
0.99
0.00
3.3
2.8
—
—
—
0
0
42
419
1.00
0.00
1.4
1.4
—
—
—
0
0
6
59
1.02
0.00
3.7
2.4
62.6
58.5
%
—
6
59
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
6.3
—
—
—
0
0
0
6
0.00
0.00
0.0
3.2
—
—
—
0
0
6
62
0.97
0.00
1.7
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
1.7
—
0
5
0
8
0.00
0.00
0.0
4.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
5
53
0.94
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
8139.3
—
0
9
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
6
65
0.92
0.00
5.5
5.8
335.7
379.6
umol/l
—
6
57
6
69
0.87
0.00
1.2
1.0
—
5.4
—
0
36
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint L12_GRANUANNU and mortality.

Females

Parameter HR [95% CI] p-value
L12_GRANUANNU 0.932 [0.77, 1.13] 0.465
Birth year 0.995 [0.99, 1.0] 0.213

During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 2180 females with L12_GRANUANNU died.

Males

Parameter HR [95% CI] p-value
L12_GRANUANNU 1.372 [1.06, 1.78] 0.018
Birth year 0.989 [0.98, 1.0] 0.019

During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 691 males with L12_GRANUANNU died.

Mortality risk

Mortality risk for people of age

years, who have L12_GRANUANNU.

N-year risk Females Males
1 0.093% 0.277%
5 0.604% 1.707%
10 1.334% 4.135%
15 2.672% 7.778%
20 4.563% 13.472%

Relationships between endpoints

↥

Index endpoint: L12_GRANUANNU – Granuloma annulare

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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