granuloma annulare: a fairly rare, chronic dermatological condition which presents as reddish bumps on the skin arranged in a circle or ring. It can initially occur at any age and is significantly more common in females (80/20 ratio).
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
561 |
4. Check minimum number of eventsNone |
561 |
5. Include endpointsNone |
561 |
6. Filter based on genotype QC (FinnGen only) |
540 |
Control definitions (FinnGen only)
- Control exclude
- L12_OTHERSKINSUBCUTIS
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- L92
- Name in latin
- Granuloma anulare
Similar endpoints
↥List of similar endpoints to
Granuloma annulare
based on the number of shared cases.
Similar with more cases:
- Granulomatous disorders of skin and subcutaneous tissue
- Other disorders of skin and subcutaneous tissue
- Diseases of the skin and subcutaneous tissue
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3343 | 2530 | 797 |
| Only index persons | 3180 | 2436 | 744 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.07 | 0.02 |
| Only index persons | 0.08 | 0.09 | 0.03 |
| Median age at first event (years) | |||
| Whole population | 50.83 | 50.97 | 50.58 |
| Only index persons | 51.04 | 51.08 | 50.91 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 540 | 432 | 108 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.05 |
| Median age at first event (years) | 54.36 | 52.17 | 63.10 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 561
- Matched controls
- 5610
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L92.0
ICD-10 Finland
Granuloma annulare
4503599627370496.0
307.7
557
6
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
21.3
267.7
243
194
L30.9
ICD-10 Finland
Dermatitis, unspecified
5.7
88.7
249
693
D07AC01
ATC
betamethasone; topical
4.4
66.4
323
1323
D07AD01
ATC
clobetasol; topical
4.6
57.7
182
533
XQ848
NOMESCO Finland
Dermatological photography
11.3
44.3
48
46
E0000UV, ,
ATC
2.7
29.5
304
1704
D07AC13
ATC
mometasone; topical
2.8
29.2
227
1103
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
5.0
26.6
60
130
TQW80
NOMESCO Finland
Local dermatologic skincare
8.6
24.6
32
39
L98.9
ICD-10 Finland
Disorder of skin and subcutaneous tissue, unspecified
40.4
21.9
27
7
A10AB05
ATC
insulin aspart; parenteral
3.9
20.5
65
183
P01BA02
ATC
hydroxychloroquine; oral
3.4
19.8
79
259
L92.1
ICD-10 Finland
Necrobiosis lipoidica, not elsewhere classified
+∞
17.8
17
*
A10AE04
ATC
insulin glargine; parenteral
3.2
17.2
76
265
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
4.3
15.7
42
104
A10AE05
ATC
insulin detemir; parenteral
3.9
15.6
48
132
S29
ICPC
Skin symptom/complaint other
2.4
15.3
127
610
L92.9
ICD-10 Finland
Granulomatous disorder of skin and subcutaneous tissue, unspecified
+∞
14.6
14
*
A10AC01
ATC
insulin (human); parenteral
3.1
14.3
62
213
J04BA02
ATC
dapsone; oral
43.7
14.2
17
*
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.2
13.7
145
770
T89
ICPC
Diabetes insulin dependent
3.8
13.0
40
110
A10AB01
ATC
insulin (human); parenteral
4.3
12.9
34
83
103
Kela drug reimbursment
Diabetes, insulin-treated
2.1
12.8
149
819
D48.5
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Skin
3.3
12.6
50
163
D07AB02
ATC
hydrocortisone butyrate; topical
2.0
12.4
191
1158
QAA05
NOMESCO Finland
Incision for biopsy of skin of head or neck
9.9
11.8
23
24
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.2
11.7
122
639
H04AA01
ATC
glucagon; nasal, parenteral
5.0
11.5
25
52
L94.0
ICD-10 Finland
Localized scleroderma [morphea]
122.4
11.5
12
*
A10AE06
ATC
insulin degludec; parenteral
3.9
11.2
33
88
R23.8
ICD-10 Finland
Other and unspecified skin changes
2.1
10.6
123
670
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
4.3
10.0
26
63
H02AB06
ATC
prednisolone; systemic
1.8
10.0
267
1898
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
10.3
9.6
18
18
S06
ICPC
Rash localized
3.1
9.6
41
140
UJF32
NOMESCO Finland
Coloscopy
1.9
9.2
145
875
XQ845
NOMESCO Finland
Dermatoscopy
8.2
8.9
19
24
T90
ICPC
Diabetes non-insulin dependent
1.9
8.9
123
709
L43.8
ICD-10 Finland
Other lichen planus
7.4
8.8
20
28
A10AB04
ATC
insulin lispro; parenteral
3.7
8.8
28
79
N03AX12
ATC
[U] gabapentin; oral
2.0
8.7
103
562
SPAT1262
SPAT
Handing over of treatment supplies
2.1
8.6
96
512
D01AC20
ATC
imidazoles/triazoles in combination with corticosteroids; topical
1.9
8.6
132
787
M25.5
ICD-10 Finland
Pain in joint
1.7
8.5
204
1390
N02BE01
ATC
paracetamol; systemic, rectal
2.3
8.5
506
4475
L92.8
ICD-10 Finland
Other granulomatous disorders of skin and subcutaneous tissue
+∞
8.4
8
*
WXQ10
NOMESCO Finland
Psoralen - Ultraviolet A therapy with systemic sensitivisation
+∞
8.4
8
*
SPAT1263
SPAT
Sampling
1.7
8.3
243
1744
D02AE01
ATC
carbamide; topical
2.7
8.3
44
169
J02AC01
ATC
fluconazole; systemic
1.7
8.1
260
1908
S08
ICPC
Skin colour change
3.0
8.1
36
126
E000001, ,
ATC
1.9
8.0
122
724
D01AE15
ATC
terbinafine; topical
2.6
7.8
44
175
D07AB08
ATC
desonide; topical
2.2
7.8
70
344
QDA25
NOMESCO Finland
Destruction of lesion of skin of lower limb
45.6
7.7
9
*
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.5
7.7
51
219
J01FF01
ATC
clindamycin; systemic
1.8
7.6
150
963
QDE10
NOMESCO Finland
Excision of other lesion extending through all layers of skin in lower limb
3.6
7.5
24
68
A02BC02
ATC
pantoprazole; systemic
1.7
7.5
367
2982
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.4
7.3
18
42
A02BC03
ATC
lansoprazole; oral
1.7
7.2
163
1083
G56.0
ICD-10 Finland
Carpal tunnel syndrome
1.9
7.2
93
522
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
2.6
7.2
43
176
L30.0
ICD-10 Finland
Nummular dermatitis
3.5
7.2
24
70
SPAT1153
SPAT
Removal of sutures
1.7
7.2
170
1145
E10.00
ICD-10 Finland
Insulin-dependent diabetes diabetic hypoglycemic coma
8.1
7.1
15
19
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
12.2
7.1
12
10
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.1
197
1384
XW000
NOMESCO Finland
Bone marrow biopsy
3.4
7.0
25
76
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
7.0
161
1074
SPAT1255
SPAT
Intravenous administration of medicine
2.7
7.0
37
142
J01DA01
ATC
[U] cefalexin
1.6
6.9
346
2800
M01AE03
ATC
ketoprofen; systemic, rectal
1.6
6.8
196
1386
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.0
6.8
72
377
QDA99
NOMESCO Finland
Other local destruction of skin of lower limb
40.6
6.8
8
*
R06AE07
ATC
cetirizine; oral
1.6
6.8
255
1924
H53.1
ICD-10 Finland
Subjective visual disturbances
2.4
6.8
45
194
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
1.8
6.6
118
732
J45
ICD-10 Finland
Asthma
2.1
6.6
62
310
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
2.2
6.6
56
269
R42
ICD-10 Finland
Dizziness and giddiness
1.8
6.5
122
768
N02AX02
ATC
tramadol; systemic, rectal
1.6
6.5
223
1642
N03AX16
ATC
[U] pregabalin
1.7
6.5
129
826
H03AA01
ATC
levothyroxine sodium; systemic
1.7
6.4
145
960
XCW99
NOMESCO Finland
Other investigative procedure of eye
2.2
6.4
58
285
QX2XE
NOMESCO Finland
Ultrsound examination of soft tissue not elsewhere classified
3.8
6.4
19
51
A02BC01
ATC
omeprazole; systemic
1.7
6.4
151
1012
M54.4
ICD-10 Finland
Lumbago with sciatica
1.8
6.3
111
685
A02BC05
ATC
esomeprazole; systemic
1.6
6.3
224
1659
M54.5
ICD-10 Finland
Low back pain
1.6
6.3
206
1496
D86.3
ICD-10 Finland
Sarcoidosis of skin
18.3
6.3
9
5
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
6.3
64
330
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
6.3
231
1725
S87
ICPC
Dermatitis/atopic eczema
3.7
6.2
19
52
QCA99
NOMESCO Finland
Other local destruction of skin of upper limb
27.0
6.2
8
*
A10AA02, ,
ATC
3.3
6.2
23
72
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.2
6.2
54
262
GD1AD
NOMESCO Finland
Thorax CT examination
2.7
6.2
32
122
L60.0
ICD-10 Finland
Ingrowing nail
2.7
6.2
33
128
S01
ICPC
Pain/tenderness of skin
3.0
6.1
27
94
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
1.8
6.1
98
588
E10
ICD-10 Finland
Type 1 diabetes mellitus
4.2
6.1
16
39
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.1
6.1
62
319
J01FA10
ATC
azithromycin; systemic
1.6
6.0
337
2755
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
82
312
2.91
15.89
2.3
2.4
24.30
24.37
au/ml
—
5
19
320
2238
2.00
14.26
6.6
5.4
28.78
28.94
%
0.10
307
2103
56
182
3.31
14.16
1.8
1.9
37.79
39.26
u/l
0.20
50
162
208
1267
2.02
13.60
4.8
3.8
11.49
9.89
mg/mmol
0.19
119
748
315
2216
1.96
13.53
6.4
5.2
56.18
56.68
%
0.34
302
2081
362
2672
2.00
13.49
8.5
8.6
3.96
4.00
e9/l
0.15
318
2335
215
1333
1.99
13.31
3.9
3.1
6.82
7.16
mmol/l
0.54
176
1131
198
1200
2.00
13.02
4.0
3.2
825.42
236.60
mg/l
0.56
117
730
439
3542
2.10
11.87
5.0
3.9
12.69
11.28
mm/h
1.35
416
3273
298
2148
1.83
10.99
6.8
6.0
1.22
1.22
mmol/l
0.25
254
1828
255
1768
1.81
10.56
2.2
1.9
99.34
97.99
pmol/l
0.15
141
889
435
3562
1.98
10.37
8.4
6.7
77.42
77.13
u/l
0.05
416
3325
151
896
1.94
10.17
1.4
1.3
19.29
31.30
iu/ml
1.67
47
303
260
1837
1.77
9.92
5.2
4.1
35.90
35.96
g/l
0.06
238
1723
144
865
1.89
9.25
1.3
1.3
4.94
12.18
u/ml
1.20
58
331
261
1880
1.73
9.05
16.6
11.0
1.23
1.19
inr
0.26
86
577
182
1189
1.79
8.86
1.5
1.3
2.22
2.26
u/ml
0.01
53
329
209
1431
1.73
8.59
2.6
2.3
55.77
61.94
u/l
1.04
192
1317
508
4518
2.32
8.08
6.1
4.8
1.86
1.84
mu/l
0.15
473
4155
269
2004
1.66
7.87
2.6
2.2
79.93
76.73
nmol/l
1.05
247
1804
305
2347
1.66
7.85
6.2
5.6
11.33
10.77
umol/l
0.22
287
2213
18
40
4.62
7.70
1.1
1.2
—
—
—
0
0
262
1948
1.65
7.66
5.9
5.5
1.22
1.22
mmol/l
0.29
241
1776
528
4800
2.70
7.57
18.2
13.3
3.96
3.94
mmol/l
1.36
513
4650
527
4788
2.66
7.54
18.1
13.3
139.43
139.70
mmol/l
1.88
513
4651
326
2574
1.64
7.39
5.0
4.1
7.04
6.51
mmol/l
3.01
304
2368
521
4728
2.43
7.13
16.9
12.0
19.50
20.93
mg/l
0.49
446
3655
445
3851
1.75
6.69
5.1
4.1
14.83
14.64
pmol/l
0.85
415
3505
207
1513
1.58
6.13
3.5
2.8
30.24
29.94
u/l
0.06
193
1436
29
106
2.83
6.05
2.3
2.8
—
—
—
0
0
76
423
1.92
6.01
2.2
1.9
385.93
376.04
nmol/l
0.18
69
394
207
1526
1.56
5.85
3.0
3.1
2.36
2.36
mmol/l
0.21
179
1354
477
4260
1.80
5.82
7.1
5.2
42.03
39.02
mmol/mol
6.05
447
3958
75
429
1.86
5.45
7.3
4.1
248.93
258.73
u/l
0.14
70
407
537
5029
2.58
5.25
12.9
9.4
25.83
24.38
u/l
1.36
520
4850
175
1274
1.54
5.10
2.5
2.0
141.05
222.13
u/l
0.83
169
1205
32
139
2.38
4.78
1.3
1.7
—
—
—
0
0
84
521
1.72
4.66
6.5
4.7
1.10
1.05
mmol/l
0.80
79
474
207
1586
1.48
4.66
3.8
3.3
35.78
35.56
ng/l
0.01
132
1009
20
69
2.97
4.65
1.1
1.1
154.80
22.17
iu/ml
—
5
12
10
16
6.34
4.31
1.1
1.0
—
—
—
0
0
153
1119
1.51
4.26
3.1
2.4
352.08
6578.32
umol/l
4.85
134
987
495
4564
1.72
4.17
4.9
4.2
6.22
5.81
mmol/l
5.44
452
4184
56
320
1.83
4.10
1.8
3.1
68.17
67.59
g/l
0.28
49
290
270
2216
1.42
4.07
3.3
2.7
103.03
91.13
ug/l
0.42
252
2044
153
1131
1.49
4.02
3.5
3.0
1092.04
951.80
ng/l
0.31
134
946
14
36
3.96
4.02
1.1
1.1
—
94.40
—
0
5
86
560
1.63
3.97
2.8
2.2
21.90
22.74
%
0.26
74
486
97
655
1.58
3.85
2.6
2.1
13.09
13.48
umol/l
0.22
92
606
108
748
1.55
3.84
1.8
1.7
1296.80
1208.89
nmol/l
0.53
85
556
282
2349
1.40
3.82
3.7
3.5
0.00
0.00
estimate
-0.00
53
492
21
84
2.56
3.75
1.5
1.9
—
—
—
0
0
285
2385
1.40
3.72
3.8
3.5
0.00
0.01
estimate
0.50
48
450
109
763
1.53
3.69
3.8
3.4
295.83
352.50
ng/l
0.14
76
543
45
249
1.88
3.66
3.7
3.8
0.77
1.63
mmol/l
0.88
36
190
150
1127
1.45
3.58
2.6
2.0
2.91
2.97
mg/l
0.10
139
958
550
5292
3.00
3.55
24.9
17.9
39.76
39.87
%
0.18
517
5003
550
5293
2.99
3.52
24.9
18.0
257.62
257.12
e9/l
0.06
544
5170
550
5296
2.96
3.46
24.9
18.0
4.42
4.45
e12/l
0.92
541
5164
139
1036
1.45
3.45
1.7
1.5
20.51
21.19
nmol/l
0.22
120
880
93
638
1.55
3.45
2.5
1.8
—
—
—
0
0
95
657
1.54
3.39
3.2
3.1
0.81
0.82
mmol/l
0.25
90
623
165
1275
1.42
3.36
1.8
1.6
1.30
1.36
mmol/l
0.46
130
1083
279
2361
1.36
3.24
4.9
4.7
0.00
0.00
estimate
0.50
52
463
70
458
1.60
3.18
6.5
5.8
104.91
104.30
mmol/l
0.69
70
458
30
152
2.03
3.16
2.4
1.7
—
—
—
0
0
19
81
2.39
3.01
1.3
1.4
268.50
245.34
u/ml
—
8
46
480
4478
1.50
2.87
15.2
11.1
81.44
84.10
ml/min/173m2
1.72
396
3643
31
165
1.93
2.87
3.1
1.8
—
—
—
0
0
19
85
2.28
2.73
1.3
1.3
—
—
—
0
0
8
19
4.26
2.68
3.6
1.7
—
—
—
0
0
8
19
4.26
2.68
3.6
1.7
—
—
—
0
0
46
284
1.68
2.64
1.8
1.5
—
—
—
0
0
54
350
1.60
2.57
2.7
3.4
2.25
2.09
mmol/l
0.13
43
276
13
50
2.64
2.55
2.3
1.6
—
—
—
0
0
19
88
2.20
2.53
3.3
2.0
129.00
131.16
g/l
0.08
12
58
51
328
1.61
2.51
3.9
3.6
84.76
74.83
ng/l
0.38
43
293
16
69
2.36
2.50
1.1
1.3
—
—
—
0
0
109
824
1.40
2.47
2.5
2.7
2.46
2.44
mmol/l
0.48
92
725
27
474
0.55
2.46
1.6
1.6
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
97
2.10
2.40
2.4
3.8
0.44
0.35
u/ml
0.41
12
48
120
930
1.37
2.34
2.0
1.6
121428994.26
25443474.31
pmol/l
0.36
98
790
13
53
2.49
2.29
1.4
1.3
—
—
—
0
0
8
23
3.51
2.27
1.0
1.2
—
—
—
0
0
348
3135
1.29
2.23
3.4
2.9
47.18
43.02
u/l
0.47
323
2929
15
67
2.27
2.19
2.5
1.4
—
—
—
0
0
15
67
2.27
2.19
2.5
1.4
—
—
—
0
0
15
67
2.27
2.19
1.1
1.3
—
—
—
0
0
23
122
1.92
2.19
1.1
1.4
320.85
318.61
ug/g
0.02
13
73
25
137
1.86
2.17
2.0
1.8
2.72
2.97
g/l
0.87
25
127
14
61
2.33
2.16
2.4
1.5
—
—
—
0
0
71
509
1.45
2.15
2.3
2.5
8.28
7.22
umol/l
0.14
61
424
19
96
2.01
2.07
3.1
1.5
—
—
—
0
0
17
84
2.06
1.97
4.6
3.8
53.00
57.13
%
0.67
17
84
7
22
3.21
1.88
1.0
1.0
14.00
37.14
u/l
—
7
22
7
22
3.21
1.88
1.0
1.0
80.86
100.18
u/l
—
7
22
9
34
2.67
1.87
1.2
1.5
—
—
—
0
0
13
59
2.23
1.85
4.8
2.9
1.38
1.05
%
0.24
13
53
27
160
1.72
1.85
4.0
5.2
1.89
1.47
%
1.40
27
150
489
4659
1.39
1.83
5.1
4.2
4.66
4.79
mmol/l
1.97
462
4324
5
12
4.19
1.82
4.2
2.0
—
—
—
0
0
5
12
4.19
1.82
4.2
2.0
—
—
—
0
0
5
12
4.19
1.82
4.2
2.0
—
—
—
0
0
18
94
1.95
1.82
3.0
1.5
—
—
—
0
0
7
23
3.07
1.80
1.1
1.5
—
62.00
—
0
5
470
4454
1.34
1.80
4.5
3.7
1.33
1.25
mmol/l
1.82
432
4093
8
29
2.78
1.79
6.0
3.0
—
—
—
0
0
6
18
3.36
1.75
1.8
3.1
39095.17
35800.00
ug/l
—
6
18
25
149
1.71
1.69
2.0
1.8
3.50
3.68
g/l
0.37
25
139
25
149
1.71
1.69
2.0
1.8
—
—
—
0
0
25
149
1.71
1.69
2.0
1.8
7.08
7.61
g/l
1.42
25
139
59
429
1.42
1.69
3.3
3.9
9.03
18.72
ug/l
0.40
48
353
12
55
2.21
1.68
2.4
1.6
1.30
1.52
mmol/l
0.61
12
55
494
4729
1.37
1.66
5.6
4.6
2.74
2.83
mmol/l
1.28
451
4377
50
355
1.45
1.63
5.4
3.6
1.23
1.23
mmol/l
0.09
42
304
18
98
1.86
1.63
1.7
1.3
—
—
—
0
0
5
14
3.59
1.62
1.4
2.4
—
—
—
0
0
5
14
3.59
1.62
1.4
2.4
—
—
—
0
0
34
223
1.56
1.61
1.4
1.7
3.93
2.76
mg/l
0.30
25
157
6
20
3.02
1.58
3.8
1.7
—
—
—
0
0
251
2237
1.22
1.55
2.9
2.4
—
—
—
0
0
14
71
2.00
1.55
2.3
1.5
—
—
—
0
0
8
33
2.44
1.54
2.8
1.6
—
—
—
0
0
23
138
1.70
1.54
2.1
1.8
9.60
10.04
g/l
0.27
23
127
484
4633
1.33
1.51
5.0
4.1
1.48
1.54
mmol/l
2.59
445
4285
6
21
2.88
1.51
3.8
1.7
—
—
—
0
0
10
45
2.24
1.47
1.1
1.1
58.40
58.37
u/l
—
10
40
207
1818
1.22
1.46
3.8
3.5
—
—
—
0
0
9
38
2.39
1.46
1.2
1.0
—
—
—
0
0
6
22
2.75
1.44
3.8
1.7
—
—
—
0
0
90
724
1.29
1.37
2.6
2.7
0.77
1.04
e6/l
0.49
43
394
5
17
2.96
1.36
1.4
3.1
30.60
32.53
umol/l
—
5
17
15
83
1.83
1.32
4.3
3.7
3.49
4.20
e9/l
0.87
15
83
57
436
1.34
1.25
2.0
1.7
—
—
—
0
0
37
263
1.44
1.24
1.9
2.2
6442.14
5313.20
u/l
0.11
11
120
9
45
2.02
1.23
2.9
1.6
—
—
—
0
0
8
37
2.18
1.22
3.6
1.6
—
—
—
0
0
8
37
2.18
1.22
3.6
1.6
—
—
—
0
0
8
37
2.18
1.22
3.6
1.6
—
—
—
0
0
143
1231
1.22
1.21
3.5
2.9
0.19
0.41
e6/l
1.95
93
915
15
86
1.76
1.20
3.1
2.7
4.86
7.66
umol/l
—
10
62
57
440
1.33
1.18
2.0
1.8
—
—
—
0
0
17
102
1.69
1.17
1.5
1.3
—
—
—
0
0
440
4202
1.22
1.14
19.8
14.6
14.86
14.71
%
0.20
433
4135
28
192
1.48
1.14
2.8
3.6
24.46
24.43
mmol/l
0.02
28
187
7
30
2.35
1.12
1.6
1.2
24.87
8.91
u/l
—
7
24
347
3255
1.17
1.06
3.3
3.3
—
—
—
0
0
7
36
1.96
0.97
1.4
1.4
—
—
—
0
0
9
51
1.78
0.95
1.3
1.1
—
—
—
0
0
7
37
1.90
0.94
1.4
1.4
—
—
—
0
0
6
27
2.23
0.93
1.5
1.8
10.58
11.71
umol/l
—
6
27
50
394
1.30
0.93
1.2
1.2
77.73
159.30
iu/ml
2.65
25
168
20
135
1.50
0.90
1.4
1.5
—
—
—
0
0
23
160
1.46
0.90
1.6
1.7
—
—
—
0
0
152
1352
1.17
0.89
3.6
3.0
39.31
62.74
e6/l
0.52
104
1025
18
119
1.53
0.89
2.4
1.8
37.82
38.52
g/l
0.18
18
109
31
229
1.37
0.89
2.2
1.6
—
—
—
0
0
81
688
1.21
0.81
2.9
2.9
2.69
3.57
e6/l
0.53
37
358
6
33
1.83
0.79
1.3
1.4
65.00
68.97
umol/l
—
6
33
0
27
0.00
0.77
0.0
1.5
—
—
—
0
0
118
1041
1.17
0.77
1.8
1.6
—
—
—
0
0
124
1099
1.16
0.77
2.6
2.0
—
—
—
0
0
9
55
1.65
0.73
2.9
1.5
—
—
—
0
0
67
565
1.21
0.73
4.6
4.2
32.67
32.74
%
0.02
48
378
30
230
1.32
0.71
10.1
7.2
25.27
24.61
mmol/l
0.54
30
219
14
204
0.68
0.69
1.1
1.4
—
—
—
0
0
14
204
0.68
0.69
1.1
1.4
—
—
—
0
0
14
203
0.68
0.68
1.1
1.4
—
—
—
0
0
5
91
0.55
0.67
1.0
1.3
4.07
2.68
ug/l
—
5
82
5
28
1.79
0.66
1.0
1.3
—
—
—
0
0
115
1027
1.15
0.65
3.7
3.7
1.01
1.02
kg/l
0.86
21
137
7
44
1.60
0.65
2.6
3.4
—
—
—
0
0
7
44
1.60
0.65
2.0
1.3
—
—
—
0
0
43
351
1.24
0.65
9.0
7.3
115.49
120.08
g/l
0.78
43
343
6
105
0.57
0.62
2.0
1.5
—
—
—
0
0
16
113
1.43
0.61
1.4
1.2
—
—
—
0
0
16
221
0.72
0.61
1.2
1.5
—
—
—
0
0
25
192
1.32
0.60
1.4
1.4
178.07
255.98
miu/ml
0.47
14
93
17
123
1.39
0.58
2.8
4.2
74.98
57.67
mg/l
0.18
11
96
17
123
1.39
0.58
2.8
4.2
21.28
26.97
mg/l
0.91
11
95
121
1096
1.13
0.56
3.0
1.7
1.38
1.10
mg/l
0.41
94
846
8
55
1.46
0.56
1.8
1.3
—
—
—
0
0
8
55
1.46
0.56
1.8
1.3
—
—
—
0
0
6
37
1.63
0.55
3.7
1.7
—
—
—
0
0
63
545
1.18
0.55
1.7
1.6
1.42
1.42
%
0.01
50
471
19
248
0.76
0.52
1.1
1.5
—
—
—
0
0
15
203
0.73
0.52
1.1
1.4
—
—
—
0
0
74
653
1.15
0.51
1.9
2.0
—
—
—
0
0
140
1288
1.12
0.51
4.7
3.7
0.00
0.01
estimate
0.69
47
464
6
41
1.47
0.50
1.3
1.8
15.50
22.56
ug/l
—
6
41
7
45
1.56
0.49
1.0
1.0
—
—
—
0
0
7
46
1.53
0.48
2.3
2.2
—
—
—
0
0
10
68
1.48
0.47
4.4
1.6
—
—
—
0
0
23
182
1.28
0.47
1.5
1.6
—
—
—
0
0
7
48
1.46
0.47
1.1
1.3
—
—
—
0
0
7
48
1.46
0.47
1.1
1.3
—
—
—
0
0
49
422
1.18
0.46
8.2
7.3
12.73
12.31
kpa
0.25
49
407
18
139
1.30
0.44
2.6
1.8
2.85
5.25
iu/l
1.23
11
51
50
434
1.17
0.44
3.4
2.9
—
—
—
0
0
49
425
1.17
0.43
8.2
7.3
1.71
1.12
mmol/l
0.64
43
351
11
78
1.42
0.43
1.1
1.5
—
—
—
0
0
11
78
1.42
0.43
1.1
1.5
—
—
—
0
0
11
78
1.42
0.43
1.3
1.4
—
—
—
0
0
27
221
1.23
0.43
1.4
1.4
—
—
—
0
0
5
31
1.62
0.43
1.2
1.0
—
—
—
0
0
5
31
1.62
0.43
4.6
1.6
—
—
—
0
0
5
31
1.62
0.43
1.0
1.1
—
—
—
0
0
5
31
1.62
0.43
1.4
1.4
—
—
—
0
0
15
113
1.34
0.43
1.9
1.6
—
—
—
0
0
8
56
1.43
0.42
1.8
1.3
—
—
—
0
0
8
58
1.38
0.41
1.8
1.2
—
—
—
0
0
8
58
1.38
0.41
1.8
1.2
—
—
—
0
0
8
58
1.38
0.41
1.8
1.2
—
—
—
0
0
5
33
1.52
0.41
3.4
1.0
279.20
298.89
mg/l
—
5
28
8
60
1.34
0.40
1.0
1.1
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
5
37
1.35
0.37
1.0
1.1
—
—
—
0
0
10
72
1.40
0.37
1.2
1.1
—
—
—
0
0
9
70
1.29
0.37
1.3
1.1
—
—
—
0
0
6
43
1.40
0.35
4.0
1.6
—
—
—
0
0
40
349
1.16
0.35
1.7
1.7
—
—
—
0
0
21
172
1.23
0.34
2.8
2.7
0.73
0.67
%
0.33
21
172
39
340
1.16
0.34
6.3
6.5
1.45
1.36
mmol/l
0.26
39
330
46
407
1.14
0.33
2.3
2.4
37.92
34.25
u/l
0.13
37
346
6
46
1.31
0.33
1.0
1.1
—
—
—
0
0
13
102
1.28
0.30
1.2
1.2
1.25
2.96
e6/l
—
8
84
13
102
1.28
0.30
1.3
1.2
4.50
99.82
e6/l
—
8
87
19
158
1.21
0.28
1.7
1.7
—
—
—
0
0
13
104
1.26
0.26
1.5
1.1
—
—
—
0
0
78
725
1.09
0.26
1.9
2.1
—
—
—
0
0
117
1106
1.07
0.26
1.5
1.4
—
—
—
0
0
58
533
1.10
0.24
7.4
6.0
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
5
38
1.32
0.23
1.0
1.1
—
—
—
0
0
75
702
1.08
0.22
4.9
4.8
1.90
2.76
ug/l
0.95
64
629
27
304
0.88
0.21
1.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
0
12
0.00
0.21
0.0
1.2
—
—
—
0
0
0
12
0.00
0.21
0.0
1.1
—
—
—
0
0
0
13
0.00
0.21
0.0
1.3
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
6
49
1.23
0.20
1.0
1.1
—
—
—
0
0
7
58
1.21
0.18
3.6
1.5
—
—
—
0
0
9
79
1.14
0.15
1.1
1.7
—
—
—
0
0
39
418
0.93
0.14
3.4
2.9
0.74
0.79
ug/l
0.22
29
274
12
105
1.15
0.11
2.3
4.1
45.40
30.62
mg/l
—
5
67
26
241
1.08
0.10
1.3
1.5
—
—
—
0
0
21
228
0.92
0.10
1.2
1.4
—
—
—
0
0
5
48
1.04
0.09
1.0
1.1
—
—
—
0
0
17
185
0.92
0.08
2.7
1.7
—
—
—
0
0
7
66
1.06
0.08
5.1
5.9
334.00
379.59
umol/l
—
7
58
6
72
0.83
0.07
1.2
1.6
—
—
—
0
0
57
553
1.03
0.06
5.3
4.2
22.43
21.33
%
0.17
26
267
19
178
1.07
0.05
2.2
1.9
—
—
—
0
0
12
131
0.91
0.05
1.6
1.3
—
—
—
0
0
29
279
1.04
0.04
1.3
1.4
—
—
—
0
0
12
129
0.93
0.03
1.0
1.3
6.14
10.20
u/l
—
7
104
12
127
0.94
0.01
1.4
1.1
—
—
—
0
0
44
446
0.99
0.00
1.9
1.8
—
—
—
0
0
14
144
0.97
0.00
1.1
1.1
—
—
—
0
0
14
143
0.98
0.00
1.1
1.1
—
—
—
0
0
14
138
1.01
0.00
1.4
1.4
—
—
—
0
0
35
353
0.99
0.00
2.4
2.5
63.84
68.47
ml/min/173m2
0.25
19
141
37
369
1.00
0.00
1.3
1.5
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
8
86
0.93
0.00
1.1
1.2
—
—
—
0
0
6
61
0.98
0.00
3.3
1.9
12.67
13.23
%
—
6
61
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
27.70
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
65.20
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
7
72
0.97
-0.00
1.3
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint L12_GRANUANNU and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANUANNU | 0.932 [0.77, 1.13] | 0.465 |
| Birth year | 0.995 [0.99, 1.0] | 0.213 |
During the follow-up period (1.1.1998 — 31.12.2019), 151 out of 2180 females with L12_GRANUANNU died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| L12_GRANUANNU | 1.372 [1.06, 1.78] | 0.018 |
| Birth year | 0.989 [0.98, 1.0] | 0.019 |
During the follow-up period (1.1.1998 — 31.12.2019), 95 out of 691 males with L12_GRANUANNU died.
Mortality risk
Mortality risk for people of age
years, who have L12_GRANUANNU.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.277% |
| 5 | 0.604% | 1.707% |
| 10 | 1.334% | 4.135% |
| 15 | 2.672% | 7.778% |
| 20 | 4.563% | 13.472% |
Relationships between endpoints
↥Index endpoint: L12_GRANUANNU – Granuloma annulare
GWS hits: 1
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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