Arthropathy in ulcerative colitis

ULCER_ARTHR

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

2 out of 7 registries used, show all original rules.

465

4. Check minimum number of events

None

465

5. Include endpoints

None

465

6. Filter based on genotype QC (FinnGen only)

465

Control definitions (FinnGen only)

Control exclude
PSOR_ENTE_ARTHR

Extra metadata

First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1853 1058 791
Only index persons 1802 1037 765
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.02
Only index persons 0.03 0.04 0.03
Median age at first event (years)
Whole population 45.60 44.83 46.65
Only index persons 45.25 44.58 46.16

-FinnGen-

Key figures

All Female Male
Number of individuals 465 302 163
Unadjusted period prevalence (%) 0.09 0.10 0.07
Median age at first event (years) 46.62 44.93 49.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
423
Matched controls
4229
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
208
Kela drug reimbursment
Ulcerative colitis and Crohn's disease
390.8
323.0
377
86
M07.5*K51.9
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
323.0
367
*
A07EC02
ATC
mesalazine; oral, rectal
275.5
323.0
364
92
K51.9
ICD-10 Finland
Ulcerative colitis, unspecified
228.3
321.6
305
47
K51.5
ICD-10 Finland
Left sided colitis
188.2
283.3
275
41
A07EC01
ATC
sulfasalazine; oral, rectal
55.6
235.9
294
166
L04AX01
ATC
azathioprine; systemic
54.8
186.9
224
85
A07EA02
ATC
hydrocortisone; rectal
144.5
184.4
187
23
K51.3
ICD-10 Finland
Ulcerative (chronic) rectosigmoiditis
145.4
180.5
183
22
UJF32
NOMESCO Finland
Coloscopy
22.1
168.2
327
565
M07.5
ICD-10 Finland
Arthropathy in ulcerative colitis
+∞
165.8
148
*
A07EA06
ATC
budesonide; oral, local oral
58.4
143.8
168
47
K51.8
ICD-10 Finland
Other ulcerative colitis
103.6
126.8
135
19
H02AB06
ATC
prednisolone; systemic
18.5
122.1
380
1367
K51.1
ICD-10 Finland
Ulcerative (chronic) ileocolitis
111.0
113.4
120
15
L04AX03
ATC
methotrexate; systemic (immunosuppressants)
16.3
102.5
181
185
202
Kela drug reimbursment
Connective tissue diseases, rheumatoid arthritis and comparable disease
13.9
99.4
192
238
K51.2
ICD-10 Finland
Ulcerative (chronic) proctitis
83.5
92.6
102
16
UJF30
NOMESCO Finland
Ileoscopy through colon
13.3
87.0
168
199
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
8.0
83.4
262
712
K51.0
ICD-10 Finland
Ulcerative (chronic) pancolitis
110.8
82.7
88
10
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
13.5
73.8
138
146
K51
ICD-10 Finland
Ulcerative colitis
146.5
70.4
73
6
L04AB04
ATC
adalimumab; parenteral
31.4
68.8
92
37
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
12.0
68.4
136
161
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
11.6
59.7
119
138
H02AB07
ATC
prednisone; oral
7.5
58.9
163
328
M07.3*L40.5
ICD-10 Finland
Other psoriatic arthropathies
614.1
55.9
54
*
UJF14
NOMESCO Finland
Enteroscopy of ileoanal anastomosis
88.5
55.7
61
8
J01MA02
ATC
ciprofloxacin; systemic
5.1
53.9
261
1012
281
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab
17.9
47.7
76
51
313
Kela drug reimbursment
Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)
16.3
46.5
77
57
L01BA01
ATC
methotrexate; systemic (folic acid analog.)
14.5
45.9
80
67
K50.9
ICD-10 Finland
Crohn disease, unspecified
24.9
45.2
64
30
A07EA01
ATC
prednisolone; rectal
108.0
44.8
48
5
326
Kela drug reimbursment
Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)
40.1
44.8
56
16
L01BB02
ATC
mercaptopurine; oral
47.4
44.7
54
13
K50.1
ICD-10 Finland
Crohn disease of large intestine
34.4
44.0
57
19
M07.4*K50.9
ICD-10 Finland
Arthropathy in Crohn's disease [regional enteritis]
+∞
39.2
37
*
UJF12
NOMESCO Finland
Enteroscopy through intestinal stoma
113.2
38.5
41
*
K50.8
ICD-10 Finland
Other Crohn disease
21.3
37.8
56
30
D94
ICPC
Chronic enteritis/ulcerative colitis
66.3
36.9
42
7
M13.9
ICD-10 Finland
Arthritis, unspecified
7.8
36.8
91
144
ZX120
NOMESCO Finland
Intravenous
6.7
35.2
98
183
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.6
34.0
232
1062
P01AB01
ATC
metronidazole; oral, rectal
3.6
33.9
255
1262
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
11.7
32.2
61
60
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.7
31.3
178
689
5561A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis
71.3
29.4
33
5
L04AB06
ATC
golimumab; parenteral
23.2
29.3
42
20
K52.88
ICD-10 Finland
Other specified noninfective gastroenteritis and colitis
17.6
29.3
46
29
56310
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Ulcerative colitis
86.4
29.2
32
*
JFH30
NOMESCO Finland
Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy
86.4
29.2
32
*
L88
ICPC
Rheumatoid/seropositive arthritis
11.3
28.2
54
54
P01BA02
ATC
hydroxychloroquine; oral
5.6
28.0
89
193
5568X
ICD-9 Finland
Idiopathic proctocolitis, Other ulcerative colitis
57.5
27.6
32
6
4AA12
NOMESCO Finland
NA
66.7
27.3
31
5
TPH04
NOMESCO Finland
Cathetrisation of vein
3.8
27.2
140
489
M45
ICD-10 Finland
Ankylosing spondylitis
13.1
26.4
47
40
M07.3
ICD-10 Finland
Other psoriatic arthropathies
276.6
26.0
26
*
JFG00
NOMESCO Finland
Closure of loop enterostomy without resection
57.5
23.3
27
5
O99.6
ICD-10 Finland
Diseases of the digestive system complicating pregnancy, childbirth and the puerperium
22.3
22.9
33
16
5562A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) proctitis
88.4
22.9
25
*
N02AX02
ATC
tramadol; systemic, rectal
2.8
22.6
228
1240
WX002
NOMESCO Finland
Sedation and analgesia
3.6
22.3
118
412
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.5
22.0
118
416
A02BC02
ATC
pantoprazole; systemic
2.8
21.2
307
2045
L40.5
ICD-10 Finland
Arthropathic psoriasis
63.4
21.1
24
*
M09.2*K51.9
ICD-10 Finland
Juvenile arthritis in ulcerative colitis
+∞
21.0
20
*
M25.5
ICD-10 Finland
Pain in joint
2.8
20.4
174
838
ND2AA
NOMESCO Finland
Hand and fingers X-ray examination
4.6
19.7
73
184
NA6BG
NOMESCO Finland
Sacro-iliac joint MRI examination with high intensity magnet
11.5
18.8
35
33
K56.6
ICD-10 Finland
Other and unspecified intestinal obstruction
11.4
17.8
33
31
K50.0
ICD-10 Finland
Crohn disease of small intestine
11.1
17.5
33
32
K83.0
ICD-10 Finland
Cholangitis
26.9
17.1
23
9
K56.5
ICD-10 Finland
Intestinal adhesions [bands] with obstruction
20.3
17.1
25
13
L04AD01
ATC
ciclosporin; systemic
9.9
17.0
34
37
M46.1
ICD-10 Finland
Sacroiliitis, not elsewhere classified
14.2
16.7
28
21
A07DA03
ATC
loperamide; oral
7.6
16.5
39
56
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
2.5
16.5
181
978
H02AB09
ATC
hydrocortisone; systemic
9.1
15.8
33
39
L04AC05
ATC
ustekinumab; parenteral
39.7
15.5
19
5
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
6.4
14.8
39
66
N02BE01
ATC
paracetamol; systemic, rectal
3.2
14.5
381
3131
1370
FHL
Colonoscopy, whole colon
28.3
14.4
19
7
4AB02
NOMESCO Finland
NA
23.2
14.3
20
9
L04AA01
ATC
[U] ciclosporin; systemic
11.5
14.2
26
24
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
3.7
14.2
66
203
NF1AE
NOMESCO Finland
Hip joint ultrasound examination
8.3
14.1
31
40
A02BC01
ATC
omeprazole; systemic
2.5
14.1
135
668
M01AH01
ATC
celecoxib; oral (coxibs)
2.8
14.0
105
452
UJF92
NOMESCO Finland
Capsular endoscopy
12.0
14.0
25
22
NH3EA
NOMESCO Finland
Feet X-ray examination with load
9.5
13.4
27
30
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
4.6
13.0
46
110
A06AC01
ATC
ispaghula (psylla seeds); oral
2.5
13.0
118
562
H02AB04
ATC
methylprednisolone; systemic
2.9
12.9
85
336
JFH11
NOMESCO Finland
Laparoscopic colectomy
133.8
12.5
13
*
A02BC05
ATC
esomeprazole; systemic
2.2
12.5
193
1185
A07EC03
ATC
olsalazine; oral
38.8
12.3
15
*
M05.8
ICD-10 Finland
Other seropositive rheumatoid arthritis
4.9
12.3
40
88
L04AA13
ATC
leflunomide; oral
7.6
12.2
28
39
WX302
NOMESCO Finland
Thoracal epidural anesthesy
5.0
11.9
38
82
N02AJ06
ATC
codeine and paracetamol; systemic
2.1
11.9
185
1134
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.6
11.5
54
167
M07.4
ICD-10 Finland
Arthropathy in Crohn disease [regional enteritis]
+∞
11.5
11
*
3005
Kela drug reimbursment
Tofacitinib
+∞
11.5
11
*
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
13.2
11.2
19
15
Z93.2
ICD-10 Finland
Ileostomy status
44.5
11.0
13
*
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
3.4
10.6
53
172
NG1DA
NOMESCO Finland
X-ray of knees
10.4
10.6
20
20
M01AH05
ATC
etoricoxib; oral
2.0
10.6
272
2000
JFH10
NOMESCO Finland
Total colectomy and ileostomy
112.7
10.5
11
*
L04AA29
ATC
tofacitinib; oral
112.7
10.5
11
*
M075, K509
ICD-10 Finland
NA
+∞
10.5
10
*
JGB50
NOMESCO Finland
Mucosal proctectomy and ileoanal anastomosis
+∞
10.5
10
*
L04AB01
ATC
etanercept; parenteral
9.9
10.4
20
21
J01DB01
ATC
cefalexin; oral
2.4
10.3
365
3056
D07AB02
ATC
hydrocortisone butyrate; topical
2.2
10.2
130
722
C10AC01
ATC
colestyramine; oral
7.5
10.1
23
32
TNG10
NOMESCO Finland
Puncture of knee
12.6
9.9
17
14
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.9
9.9
214
1459
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
9.7
109
568
K92.1
ICD-10 Finland
Melaena
5.5
9.7
28
54
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.9
9.6
39
107
JN3BD
NOMESCO Finland
Extensive abdominal CT
2.9
9.6
62
239
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
9.6
168
1054
L40.0
ICD-10 Finland
Psoriasis vulgaris
5.0
9.5
30
64
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
3.4
9.5
47
152
JFF10
NOMESCO Finland
Loop enterostomy
18.0
9.5
14
8
M075, L405
ICD-10 Finland
NA
+∞
9.4
9
*
M075, K515
ICD-10 Finland
NA
+∞
9.4
9
*
K51.4
ICD-10 Finland
Inflammatory polyps
+∞
9.4
9
*
M06.9
ICD-10 Finland
Rheumatoid arthritis, unspecified
5.5
9.4
27
52
TNH11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in ankle joint or foot joint
9.8
9.4
18
19
JAH00
NOMESCO Finland
Laparotomy
7.6
9.3
21
29
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
9.2
69
291
M01AC06
ATC
meloxicam; systemic, rectal
1.9
9.1
165
1045
N03AX16
ATC
pregabalin; oral
2.1
9.0
115
630
H04.10
ICD-10 Finland
Dry eye syndrome
3.0
8.8
52
191
UJG02
NOMESCO Finland
Proctoscopy
6.8
8.8
21
32
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
6.8
8.8
21
32
B01AB05
ATC
enoxaparin; parenteral
2.1
8.8
122
696
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
3.0
8.7
53
195
M05BA04
ATC
alendronic acid; oral
4.0
8.7
34
91
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
10.3
8.6
16
16
JH1CG
NOMESCO Finland
Extensive MRI of perianal area
28.1
8.5
11
*
JFH33
NOMESCO Finland
Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy
91.8
8.4
9
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
8.4
95
495
56399
ICD-8 Finland
Chronic enteritis and ulcerative colitis, Other
+∞
8.4
8
*
M09.1*K50.9
ICD-10 Finland
Juvenile arthritis in Crohn's disease [regional enteritis]
+∞
8.4
8
*
JFG73
NOMESCO Finland
Excision of ileal pelvic pouch
+∞
8.4
8
*
TND11
NOMESCO Finland
Injection of diagnostic or therapeutic substance in joint, wrist or hand
9.7
8.3
16
17
JHA00
NOMESCO Finland
Anal or perianal incision
7.3
8.3
19
27
R03AC02
ATC
salbutamol; inhalant
1.8
8.2
234
1712
R4110
NOMESCO Finland
Physiotherapy
2.0
8.2
115
656
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
9.2
8.1
16
18
K50
ICD-10 Finland
Crohn disease [regional enteritis]
22.5
8.0
11
5
E0000UV
ATC
NA
1.8
8.0
172
1144
M46.9
ICD-10 Finland
Inflammatory spondylopathy, unspecified
8.0
7.9
17
22
NK5AT
NOMESCO Finland
Joint injection with ultrasound guidance not elsewhere classified
13.4
7.9
13
10
K56.7
ICD-10 Finland
Ileus, unspecified
9.7
7.8
15
16
M02.9
ICD-10 Finland
Reactive arthropathy, unspecified
7.7
7.7
17
23
D07AC01
ATC
betamethasone; topical
1.9
7.6
144
914
M01AH02
ATC
rofecoxib; oral
2.5
7.6
60
261
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.1
7.5
98
541
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
3.3
7.5
37
121
J05AB11
ATC
valaciclovir; oral
2.4
7.4
62
280
M073, K519
ICD-10 Finland
NA
+∞
7.3
7
*
JFF11
NOMESCO Finland
Laparoscopic loop enterostomy
+∞
7.3
7
*
ND2BA
NOMESCO Finland
Hand and fingers extensive X-ray examination
6.0
7.3
19
33
J01MA12
ATC
levofloxacin; systemic
2.2
7.3
79
400
WX408
NOMESCO Finland
General anesthesy, balanced
1.9
7.2
122
741
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
3.3
7.2
35
113
K60.3
ICD-10 Finland
Anal fistula
6.2
7.1
18
30
A05AA02
ATC
ursodeoxycholic acid; oral
6.2
7.1
18
30
WX110
NOMESCO Finland
Local anesthesy
1.8
7.1
301
2446
M06.0
ICD-10 Finland
Seronegative rheumatoid arthritis
5.1
7.1
21
43
WVA20
NOMESCO Finland
Medicine administration
5.6
7.0
19
35
3AC01
NOMESCO Finland
NA
9.5
6.8
13
14
JN3AD
NOMESCO Finland
Abdominal CT examination
2.9
6.8
39
141
M13.0
ICD-10 Finland
Polyarthritis, unspecified
7.4
6.8
15
21
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.2
6.7
33
108
TNX00
NOMESCO Finland
Puncture and needle biopsy of soft tissue, unspecified region
4.5
6.6
22
51
R50.9
ICD-10 Finland
Fever, unspecified
2.2
6.6
67
331
K56.0
ICD-10 Finland
Paralytic ileus
12.5
6.6
11
9
JF1CG
NOMESCO Finland
Extensive MRI of small bowel
8.9
6.6
13
15
E86
ICD-10 Finland
Volume depletion
8.9
6.6
13
15
NG1AA
NOMESCO Finland
Knee X-ray examination without contrast
2.5
6.6
51
218
M17.5
ICD-10 Finland
Other secondary gonarthrosis
10.2
6.6
12
12
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.3
6.5
59
277
NDG30
NOMESCO Finland
Fusion of wrist, total
70.9
6.4
7
*
NA6AA
NOMESCO Finland
Sacro-iliac joint X-ray examination
14.6
6.4
10
7
NF1AA
NOMESCO Finland
Hip X-ray examination
3.2
6.4
32
106
XX9XE
NOMESCO Finland
Other ultrasound examination
8.3
6.4
13
16
N05CF01
ATC
zopiclone; oral
1.8
6.3
131
845
M03BX02
ATC
tizanidine; oral
1.7
6.3
276
2222
UJF34
NOMESCO Finland
Left colonoscopy
18.3
6.3
9
5
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
2.4
6.3
52
231
M01AX17
ATC
nimesulide; oral
1.9
6.3
99
584
M07.6
ICD-10 Finland
Other enteropathic arthropathies
+∞
6.3
6
*
6960A
ICD-9 Finland
Psoriasis and similar disorders, Psoriatic arthropathy
+∞
6.3
6
*
K63.3
ICD-10 Finland
Ulcer of intestine
+∞
6.3
6
*
JF1BD
NOMESCO Finland
Very extensive small bowel CT
27.1
6.2
8
*
5560A
ICD-9 Finland
Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis
27.1
6.2
8
*
JF1DG
NOMESCO Finland
Small bowel very extensive MRI with with high intensity magnet
10.2
6.1
11
11
K61.0
ICD-10 Finland
Anal abscess
5.7
6.0
16
29
WZA10
NOMESCO Finland
Long statement of health and health related matters
6.2
6.0
15
25
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
3.2
6.0
29
94

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
346
528
22.70
258.27
8.0
2.4
183.1
117.0
ug/g
2.24
333
425
280
438
14.55
196.94
2.4
1.3
—
—
—
0
0
378
1428
9.80
103.77
9.4
4.9
36.3
36.6
g/l
0.47
370
1346
339
1229
7.49
94.20
14.5
5.9
—
—
—
0
0
55
13
47.85
92.84
3.2
4.2
50.8
35.6
au/ml
—
8
5
421
1910
13.73
91.52
17.5
6.0
0.6
0.6
e9/l
2.57
407
1676
421
1916
13.65
91.01
17.5
6.1
0.0
0.0
e9/l
3.64
407
1682
424
1972
14.04
88.67
17.5
6.1
2.0
1.9
e9/l
0.62
412
1758
425
1991
14.19
87.90
17.7
6.5
0.2
0.2
e9/l
1.29
412
1770
47
11
47.42
79.26
1.8
2.1
171.2
—
au/ml
—
9
0
383
1730
7.88
78.19
17.5
6.1
0.7
0.7
%
0.66
378
1629
388
1794
8.02
76.49
17.9
6.4
8.5
8.4
%
0.36
383
1701
431
2212
13.97
75.80
19.0
9.5
4.1
4.0
e9/l
0.27
421
1943
390
1829
8.02
75.10
16.5
5.9
56.5
56.8
%
0.15
385
1733
384
1786
7.60
74.30
17.6
6.1
2.8
2.8
%
0.12
378
1682
391
1850
8.00
74.15
17.7
6.2
29.4
28.8
%
0.57
386
1752
354
1546
6.40
73.26
3.9
2.3
73.6
74.6
nmol/l
0.30
345
1418
243
834
5.01
65.94
4.0
2.1
2.9
3.0
mg/l
0.21
219
717
182
555
4.75
55.91
1.8
1.4
682.1
516.0
titre
0.45
57
119
344
1685
5.00
55.59
19.5
8.7
0.0
0.0
e9/l
0.43
323
1377
445
2811
14.56
50.24
10.6
3.9
12.1
10.1
mm/h
3.16
436
2616
91
185
5.87
44.30
1.1
1.1
—
—
—
0
0
113
281
4.99
43.73
5.6
4.5
0.3
0.4
%
0.46
29
62
111
272
5.05
43.72
5.9
4.8
0.0
0.1
%
0.57
28
67
114
286
4.96
43.65
6.2
4.8
0.0
0.1
%
2.65
32
82
117
309
4.72
41.93
6.0
4.7
0.3
0.8
%
2.59
34
93
225
945
3.68
41.87
11.0
4.9
—
—
—
0
0
148
496
3.91
38.15
1.4
1.5
—
—
—
0
0
53
71
8.30
38.13
6.5
3.9
3.8
4.6
e9/l
1.44
53
71
53
72
8.18
37.67
6.6
4.6
55.7
57.9
%
0.47
53
72
218
946
3.46
37.66
12.1
6.8
—
—
—
0
0
88
221
4.68
33.13
1.6
1.2
—
—
—
0
0
147
539
3.53
32.49
2.8
2.3
12.9
14.4
umol/l
1.48
142
500
132
453
3.67
32.29
2.7
2.3
21.6
24.6
%
1.49
116
395
170
705
3.22
30.48
1.4
1.3
11.5
9.9
u/ml
0.09
52
291
57
107
5.93
29.79
1.4
1.3
66.0
71.3
titre
—
5
8
305
1775
3.09
29.52
4.4
2.8
93.4
96.1
ug/l
0.11
294
1670
314
1861
3.12
29.33
6.3
4.5
0.0
0.0
estimate
0.00
84
347
313
1856
3.10
29.13
4.8
3.2
0.0
0.0
estimate
0.00
81
340
315
1881
3.09
28.82
4.8
3.2
0.0
0.0
estimate
0.26
81
335
159
669
3.09
27.37
1.5
1.6
—
—
—
0
0
377
2545
3.54
26.92
6.4
3.9
—
—
—
0
0
164
712
3.01
26.59
1.4
1.3
22.8
30.5
iu/ml
0.61
48
233
39
56
7.51
26.27
1.8
1.4
—
—
—
0
0
284
1666
2.81
25.70
5.9
7.0
1.2
1.2
mmol/l
0.35
242
1425
228
1236
2.66
23.52
4.0
3.3
56.5
87.5
e6/l
0.36
164
862
30
36
8.84
23.38
2.2
1.4
42.8
47.2
%
0.19
23
28
303
1913
2.68
22.46
6.8
6.4
9.7
10.5
umol/l
1.03
293
1821
171
820
2.72
22.36
4.2
3.2
—
—
—
0
0
194
995
2.63
22.10
3.5
3.9
7.4
7.4
ph
0.28
37
185
255
1500
2.55
21.64
5.3
6.3
1.2
1.2
mmol/l
0.60
244
1375
87
296
3.39
20.89
2.7
2.6
11.8
10.4
g/l
2.82
82
274
75
232
3.66
20.85
1.7
1.7
1.3
1.5
g/l
0.24
70
214
39
75
5.58
19.73
1.9
1.5
8265.8
15826.2
e6/l
0.50
31
56
229
1324
2.44
19.59
2.1
1.9
93.3
98.2
pmol/l
0.87
142
705
42
95
4.76
17.67
3.9
2.7
—
—
—
0
0
85
315
3.08
17.56
1.3
1.4
—
—
—
0
0
87
327
3.04
17.53
2.5
2.5
0.2
0.2
g/l
0.07
78
311
201
1144
2.33
17.26
4.1
2.6
63.2
54.4
u/l
1.47
191
1069
175
938
2.39
17.26
3.4
2.7
0.3
0.4
e6/l
0.38
144
700
187
1033
2.36
17.20
3.4
2.8
302.3
123.2
e6/l
0.38
159
790
215
1267
2.30
16.92
8.1
6.3
1.1
1.1
inr
0.01
86
394
21
25
8.75
16.38
2.0
1.4
39.5
42.2
%
0.09
13
18
160
845
2.36
16.13
5.2
4.0
—
—
—
0
0
247
1591
2.18
15.08
2.4
2.0
—
—
—
0
0
35
79
4.71
14.74
1.0
1.1
—
—
—
0
0
24
38
6.61
14.69
1.3
1.2
—
—
—
0
0
154
843
2.24
13.93
1.6
1.8
—
—
—
0
0
91
395
2.62
13.81
9.2
7.6
104.6
104.1
mmol/l
0.70
91
384
20
28
7.42
13.65
1.5
1.3
413.8
74.0
titre
—
8
5
134
700
2.28
13.51
2.8
2.3
5.2
6.8
e6/l
0.56
121
616
139
738
2.26
13.48
1.7
1.5
20.2
21.4
nmol/l
0.46
130
639
289
2037
2.11
13.28
5.5
4.8
6.6
6.6
mmol/l
0.07
274
1890
80
338
2.65
12.76
2.4
2.3
56.5
33.9
u/l
1.16
73
285
40
112
3.81
12.72
1.2
1.2
14.9
15.5
u/ml
—
5
20
161
925
2.13
12.69
3.3
2.6
—
—
—
0
0
126
662
2.24
12.40
3.0
2.5
558.4
563.7
mosm/kgh2o
0.08
111
566
160
924
2.12
12.39
4.7
3.4
95.5
95.1
%
0.06
152
898
167
982
2.09
12.32
5.7
3.4
0.0
0.0
estimate
0.50
82
336
129
689
2.21
12.17
2.5
1.6
420.5
22278495.5
pmol/l
0.77
116
597
73
306
2.64
11.79
5.2
3.3
—
—
—
0
0
24
48
5.22
11.59
1.8
1.3
—
—
—
0
0
157
935
2.03
10.96
2.7
2.5
2379.3
6710.1
umol/l
0.97
146
820
103
526
2.23
10.72
2.7
2.6
2.6
3.2
e6/l
0.29
68
279
447
3935
4.51
10.63
21.3
13.2
3.9
3.9
mmol/l
3.55
439
3824
17
27
6.50
10.34
1.2
1.4
7332.9
2246.5
e6/l
—
10
17
66
281
2.57
10.29
2.6
3.7
2.6
1.9
mmol/l
0.86
54
229
445
3920
4.14
10.26
21.4
13.1
139.3
139.7
mmol/l
4.05
439
3815
75
341
2.43
10.17
2.2
3.0
1.9
1.8
%
0.22
68
306
78
362
2.39
10.11
2.7
2.1
302.7
358.0
nmol/l
1.94
72
341
39
126
3.29
10.01
1.4
1.2
—
—
—
0
0
66
285
2.53
9.99
2.7
3.8
—
—
—
0
0
99
511
2.19
9.98
1.8
2.1
—
—
—
0
0
57
239
2.58
9.15
1.8
3.1
79.8
74.1
e9/l
0.42
42
181
188
1249
1.85
9.12
4.1
3.2
23.7
27.2
ng/l
0.26
107
739
22
52
4.39
8.75
1.0
1.1
—
—
—
0
0
93
493
2.11
8.68
1.3
1.2
—
—
—
0
0
159
1025
1.84
8.35
2.0
2.1
115.1
275.7
u/l
1.74
154
977
138
856
1.87
8.16
1.8
1.7
1.1
1.0
mg/l
0.02
110
651
60
272
2.38
8.15
3.0
2.9
4.2
4.1
e9/l
0.11
49
224
166
1091
1.81
8.15
4.5
2.9
—
—
—
0
0
39
143
2.89
8.09
1.2
1.3
—
—
—
0
0
97
538
2.01
7.97
2.1
1.7
1218.3
1219.5
nmol/l
0.00
68
415
81
421
2.12
7.92
3.2
2.9
5.6
6.3
umol/l
0.15
76
368
26
76
3.56
7.78
1.3
1.3
307.1
261.2
u/ml
0.29
14
44
59
274
2.32
7.58
4.4
3.3
—
—
—
0
0
65
324
2.17
7.05
3.1
4.6
4.6
20.2
ug/l
0.60
46
261
34
128
2.79
6.73
1.6
2.3
1.6
1.5
g/l
0.68
27
108
131
846
1.76
6.60
1.8
1.4
2.8
2.2
g/l
2.93
96
540
22
65
3.50
6.50
1.0
1.1
—
—
—
0
0
54
258
2.24
6.49
7.5
9.6
—
—
—
0
0
38
163
2.45
5.83
4.2
3.2
—
—
—
0
0
42
189
2.34
5.80
3.8
7.4
—
—
—
0
0
227
1740
1.60
5.73
5.0
4.0
—
—
—
0
0
81
474
1.86
5.58
1.7
1.4
—
—
—
0
0
18
52
3.56
5.50
3.6
3.0
0.3
1.0
%
1.07
13
42
18
54
3.43
5.21
1.2
1.0
1.6
1.4
g/l
0.66
13
49
13
31
4.29
5.12
1.5
1.4
—
—
—
0
0
39
181
2.26
5.04
7.6
7.9
25.8
24.9
mmol/l
0.74
39
181
31
130
2.48
5.00
4.3
4.5
—
—
—
0
0
64
360
1.90
4.97
14.5
16.5
1.0
1.2
inr
2.24
11
55
35
158
2.31
4.82
2.2
1.6
—
—
—
0
0
87
544
1.74
4.79
2.5
3.6
0.8
0.8
mmol/l
2.11
81
512
159
1159
1.57
4.77
2.6
3.3
2.3
2.4
mmol/l
3.09
152
1036
155
1126
1.56
4.71
2.6
2.2
—
—
—
0
0
49
257
2.01
4.65
2.7
3.8
1.2
1.2
mmol/l
0.06
43
227
443
4131
2.53
4.61
23.3
11.2
—
—
—
0
0
10
21
4.84
4.55
1.5
1.7
—
—
—
0
0
120
830
1.60
4.47
5.2
3.4
1.0
1.0
kg/l
0.63
13
101
60
345
1.85
4.36
7.6
10.1
1.2
1.2
mmol/l
0.02
42
268
409
3721
1.82
4.34
29.3
12.7
38.7
40.4
%
2.69
318
2924
18
61
3.03
4.33
1.1
1.2
—
—
—
0
0
20
73
2.82
4.24
2.8
1.7
—
—
—
0
0
27
117
2.39
4.09
2.5
1.8
0.3
1.3
ug/l
1.40
27
106
398
3611
1.71
4.02
4.9
4.7
1.8
2.1
mu/l
0.63
374
3369
36
180
2.08
3.90
2.7
2.8
1.1
0.1
e6/l
0.57
36
172
10
24
4.24
3.90
1.0
1.1
—
—
—
0
0
9
15
6.09
3.83
2.8
2.7
—
—
—
0
0
14
45
3.18
3.68
1.4
1.2
—
—
—
0
0
85
570
1.60
3.55
2.6
2.8
2.4
2.4
mmol/l
0.15
77
501
9
17
5.38
3.52
1.3
1.5
32.8
31.9
umol/l
—
9
17
66
416
1.68
3.51
2.1
1.6
—
—
—
0
0
6
6
10.11
3.50
1.0
1.3
—
—
—
0
0
37
196
1.96
3.45
2.0
2.4
—
—
—
0
0
20
82
2.50
3.43
1.2
1.4
—
—
—
0
0
51
301
1.78
3.42
8.7
10.8
121.4
121.8
g/l
0.05
51
288
52
310
1.76
3.37
8.7
10.7
96.7
96.1
%
0.53
52
298
23
103
2.30
3.28
4.0
3.6
3.6
3.8
mmol/l
1.44
23
92
6
7
8.66
3.27
2.3
1.9
—
—
—
0
0
341
3037
1.46
3.22
4.4
4.1
14.6
14.5
pmol/l
0.70
318
2802
19
79
2.46
3.18
2.1
2.8
7.4
7.4
ph
0.99
13
63
130
980
1.45
3.13
3.3
2.6
—
—
—
0
0
126
946
1.46
3.09
1.3
1.3
0.8
1.8
u/ml
1.11
27
272
11
34
3.29
3.07
3.8
2.4
47.7
58.2
%
—
6
22
10
29
3.50
3.06
5.2
2.8
—
—
—
0
0
9
21
4.35
3.01
1.0
1.0
—
—
—
0
0
19
82
2.37
2.95
2.4
2.9
9.0
8.4
kpa
0.69
14
77
8
17
4.77
2.93
1.5
1.5
—
—
—
0
0
126
963
1.42
2.78
2.9
3.3
—
—
—
0
0
11
37
3.02
2.71
1.3
2.2
1.6
1.1
e9/l
—
6
19
35
200
1.81
2.64
6.5
9.5
23.9
24.6
mmol/l
0.60
35
184
37
216
1.77
2.61
3.8
2.2
—
—
—
0
0
69
475
1.53
2.58
1.2
1.2
—
—
—
0
0
47
295
1.66
2.57
1.4
1.4
—
—
—
0
0
14
58
2.46
2.39
2.4
2.3
—
—
—
0
0
22
113
1.99
2.29
1.2
1.1
—
—
—
0
0
11
41
2.72
2.29
1.2
1.5
—
—
—
0
0
83
614
1.43
2.18
3.8
3.6
82.7
323.7
ng/l
1.12
50
410
14
62
2.30
2.09
1.6
4.7
—
—
—
0
0
14
62
2.30
2.09
2.6
1.4
—
—
—
0
0
375
3488
1.39
2.08
5.8
5.2
38.4
39.3
mmol/mol
1.01
364
3296
7
20
3.54
2.06
1.3
1.2
—
—
—
0
0
290
2602
1.30
2.04
3.9
3.3
—
—
—
0
0
26
148
1.80
2.03
1.1
1.1
—
—
—
0
0
21
113
1.90
1.95
1.7
1.4
289.5
301.6
ug/g
0.10
16
64
15
71
2.15
1.94
2.4
2.4
—
—
—
0
0
10
39
2.60
1.93
2.0
1.5
—
—
—
0
0
34
213
1.64
1.91
1.1
1.1
—
106.0
—
0
5
21
116
1.85
1.81
3.5
10.1
1.0
0.9
%
0.24
21
107
9
36
2.53
1.75
3.4
2.9
—
—
—
0
0
25
148
1.73
1.74
12.1
12.5
24.6
24.3
mmol/l
0.22
25
142
7
24
2.94
1.73
5.6
7.6
—
—
—
0
0
21
119
1.80
1.69
3.5
9.9
1.8
1.7
%
0.13
21
109
18
314
0.56
1.68
1.3
1.4
—
—
—
0
0
6
19
3.18
1.66
1.7
1.4
117.0
155.3
nmol/l
—
6
19
7
25
2.83
1.65
1.1
1.1
—
—
—
0
0
19
105
1.84
1.65
1.0
1.2
—
—
—
0
0
13
63
2.09
1.61
2.5
2.9
3.2
2.6
mmol/l
—
7
39
13
63
2.09
1.61
2.5
2.9
4.7
4.9
kpa
0.61
13
63
13
63
2.09
1.61
2.5
2.9
8.8
9.1
kpa
0.35
13
63
6
20
3.03
1.58
1.0
1.1
1997.8
1633.9
miu/ml
—
6
20
67
506
1.38
1.58
1.6
1.5
—
—
—
0
0
16
85
1.91
1.57
1.7
3.8
31.9
33.8
umol/l
0.12
11
70
372
3502
1.31
1.55
36.7
15.2
331.0
332.9
g/l
3.84
372
3478
16
87
1.87
1.47
5.9
4.4
—
—
—
0
0
17
95
1.82
1.45
1.5
1.8
39.8
38.9
g/l
0.36
17
84
5
16
3.15
1.44
1.2
1.4
—
—
—
0
0
6
22
2.75
1.44
1.7
1.2
—
—
—
0
0
6
22
2.75
1.44
6.2
2.8
—
—
—
0
0
26
166
1.60
1.40
2.2
2.6
1.1
1.3
%
0.64
26
166
5
17
2.96
1.36
1.2
1.4
—
—
—
0
0
13
68
1.94
1.34
1.2
1.1
—
—
—
0
0
32
218
1.50
1.32
2.7
3.6
7.4
7.4
ph
—
8
33
5
18
2.80
1.29
1.0
1.1
—
—
—
0
0
5
18
2.80
1.29
1.0
1.1
—
—
—
0
0
11
55
2.02
1.28
1.4
1.6
—
—
—
0
0
141
1622
0.81
1.26
2.9
2.6
—
—
—
0
0
6
25
2.42
1.24
1.0
1.0
—
—
—
0
0
9
45
2.02
1.24
1.0
1.1
—
—
—
0
0
32
222
1.47
1.22
2.8
3.5
5.0
5.2
kpa
0.85
26
211
119
1011
1.24
1.19
1.8
1.7
1.3
1.4
mmol/l
1.38
103
864
18
110
1.66
1.17
1.7
1.8
2.4
4.9
iu/l
—
10
43
0
34
0.00
1.16
0.0
11.0
—
0.6
—
0
34
64
508
1.30
1.12
2.4
2.1
29.6
29.4
s
0.06
58
496
8
41
1.97
1.09
2.3
3.4
—
—
—
0
0
12
67
1.81
1.05
1.3
1.4
—
—
—
0
0
5
22
2.29
1.03
1.2
1.2
10168.2
1178.0
e6/l
—
5
11
44
569
0.75
1.03
1.3
1.4
—
—
—
0
0
7
35
2.01
1.00
3.3
3.6
2.0
2.8
nmol/l
—
7
35
5
23
2.19
0.98
1.2
2.3
1940.0
2162.0
ml
—
5
23
43
330
1.33
0.97
1.1
1.2
—
—
—
0
0
14
85
1.67
0.95
1.1
1.1
—
—
—
0
0
14
85
1.67
0.95
1.1
1.1
—
—
—
0
0
6
29
2.08
0.89
1.3
2.4
15.2
25.3
ug/l
—
6
29
6
29
2.08
0.89
1.7
1.6
0.9
1.1
g/l
—
6
29
5
105
0.47
0.89
1.0
1.2
—
—
—
0
0
8
42
1.92
0.89
2.6
3.0
—
—
—
0
0
34
256
1.35
0.87
1.2
1.4
—
—
—
0
0
35
267
1.34
0.84
2.0
2.3
12.7
13.6
nmol/l
0.28
29
250
23
164
1.42
0.81
14.7
13.8
—
—
—
0
0
39
304
1.31
0.81
2.5
4.4
—
—
—
0
0
24
175
1.39
0.76
1.0
1.1
—
—
—
0
0
13
83
1.58
0.75
1.1
1.2
—
—
—
0
0
5
24
2.09
0.74
1.2
1.2
269.3
156.3
iu/ml
—
5
24
11
68
1.63
0.72
5.1
14.3
105.8
105.5
mmol/l
0.06
11
59
11
68
1.63
0.72
5.1
14.3
11.2
11.1
mmol/l
0.01
11
59
7
40
1.76
0.71
1.0
1.1
—
—
—
0
0
7
42
1.68
0.68
1.3
1.1
—
—
—
0
0
115
1028
1.16
0.67
4.1
4.0
3.2
10.7
mg/mmol
4.24
84
655
7
44
1.60
0.65
2.3
2.8
—
—
—
0
0
7
44
1.60
0.65
2.3
2.8
4.2
4.0
mmol/l
—
7
44
7
44
1.60
0.65
2.3
2.8
105.6
105.9
mmol/l
—
7
44
5
29
1.73
0.64
1.0
1.1
—
—
—
0
0
56
473
1.21
0.63
1.7
1.8
—
—
—
0
0
5
30
1.67
0.61
1.2
1.2
—
—
—
0
0
0
20
0.00
0.60
0.0
5.8
—
—
—
0
0
121
1096
1.14
0.59
1.5
1.5
—
—
—
0
0
15
106
1.43
0.58
1.1
1.3
487.4
423.9
mg/l
0.40
15
99
13
90
1.46
0.56
1.6
2.5
59.1
118.7
ug/min
—
7
54
6
39
1.55
0.53
1.2
1.9
34.0
33.5
pg
—
6
39
10
66
1.53
0.53
1.4
1.2
9.4
4.7
u/ml
—
5
27
21
161
1.32
0.52
1.2
1.3
267.1
247.4
miu/ml
—
8
80
9
63
1.44
0.52
1.6
3.0
—
—
—
0
0
6
99
0.60
0.52
1.3
1.6
—
—
—
0
0
9
65
1.39
0.51
1.1
1.0
—
3.3
u/ml
—
0
21
16
118
1.37
0.51
1.9
4.2
0.2
0.2
g/l
—
8
54
7
46
1.53
0.48
2.6
2.3
—
—
—
0
0
7
47
1.50
0.47
1.9
1.6
—
—
—
0
0
7
47
1.50
0.47
1.9
1.6
—
—
—
0
0
7
47
1.50
0.47
1.9
1.6
—
—
—
0
0
7
47
1.50
0.47
1.9
1.6
—
—
—
0
0
24
297
0.80
0.46
2.2
1.7
—
—
—
0
0
47
539
0.86
0.42
2.9
2.6
0.7
0.7
ug/l
0.10
31
326
5
33
1.52
0.41
1.2
1.1
58.0
26.8
mg/l
—
5
26
105
968
1.11
0.39
3.4
3.3
1715.8
281.9
mg/l
0.84
74
626
16
197
0.81
0.31
1.3
1.4
—
—
—
0
0
19
156
1.23
0.31
2.5
3.8
—
—
—
0
0
14
111
1.27
0.30
1.1
1.3
—
—
—
0
0
13
163
0.79
0.30
1.2
1.5
—
—
—
0
0
8
64
1.25
0.27
1.6
1.1
—
—
—
0
0
5
72
0.69
0.26
1.6
1.4
—
—
—
0
0
9
72
1.25
0.25
1.6
1.7
—
—
—
0
0
14
170
0.82
0.25
2.6
2.2
—
—
—
0
0
18
212
0.84
0.24
1.2
1.4
—
—
—
0
0
367
3726
0.93
0.24
4.2
4.1
5.9
5.8
mmol/l
0.39
348
3473
18
211
0.85
0.23
1.2
1.4
—
—
—
0
0
18
211
0.85
0.23
1.2
1.4
—
—
—
0
0
18
210
0.85
0.22
1.2
1.4
—
—
—
0
0
5
42
1.19
0.21
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
5.6
—
—
—
0
0
0
10
0.00
0.21
0.0
2.8
—
—
—
0
0
0
14
0.00
0.20
0.0
1.5
—
—
—
0
0
48
449
1.08
0.15
1.5
1.7
—
—
—
0
0
28
255
1.10
0.15
1.3
1.2
—
—
—
0
0
8
99
0.80
0.13
1.0
1.1
—
—
—
0
0
23
209
1.11
0.13
1.0
1.1
—
—
—
0
0
9
106
0.85
0.13
1.3
1.4
—
—
—
0
0
9
107
0.84
0.13
1.3
1.5
—
—
—
0
0
32
341
0.93
0.10
1.3
1.2
38.9
151.9
iu/ml
6.19
14
150
372
3749
0.96
0.10
4.0
3.7
1.4
1.3
mmol/l
2.06
356
3513
5
46
1.09
0.09
2.8
2.6
—
—
—
0
0
7
65
1.08
0.08
1.7
2.3
—
—
—
0
0
13
143
0.91
0.07
1.2
1.7
—
—
—
0
0
9
105
0.85
0.06
1.3
1.4
—
—
—
0
0
16
148
1.08
0.06
2.3
1.6
—
—
—
0
0
91
896
1.02
0.03
4.8
4.3
3.4
1.9
ug/l
0.76
82
808
388
3892
0.98
0.03
4.4
4.1
1.5
1.5
mmol/l
0.04
371
3647
112
1110
1.01
0.02
3.2
3.1
8.3
8.0
mmol/l
0.27
101
938
391
3902
1.01
0.01
4.5
4.1
4.6
4.8
mmol/l
2.59
375
3678
396
3954
1.01
0.00
4.7
4.5
2.7
2.9
mmol/l
2.64
380
3703
11
114
0.96
0.00
2.5
2.6
—
—
—
0
0
13
126
1.03
0.00
14.6
8.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.8
—
16.2
—
0
8
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
2.9
—
0
8
0
5
0.00
0.00
0.0
3.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
39
390
1.00
0.00
1.4
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
0.00
1.1
1.0
—
3.7
u/ml
—
0
16
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
5
49
1.02
0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
6.6
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint ULCER_ARTHR and mortality.

Females

Parameter HR [95% CI] p-value
ULCER_ARTHR 1.403 [1.1, 1.79] 0.006
Birth year 0.996 [0.99, 1.0] 0.305

During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 907 females with ULCER_ARTHR died.

Males

Parameter HR [95% CI] p-value
ULCER_ARTHR 1.167 [0.92, 1.49] 0.212
Birth year 0.991 [0.98, 1.0] 0.057

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 698 males with ULCER_ARTHR died.

Mortality risk

Mortality risk for people of age

years, who have ULCER_ARTHR.

N-year risk Females Males
1 0.127% 0.177%
5 0.763% 1.472%
10 1.952% 3.667%
15 3.853% 7.007%
20 6.948% 12.123%

Relationships between endpoints

Index endpoint: ULCER_ARTHR – Arthropathy in ulcerative colitis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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