Risteys · ULCER

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — M07.5, M07.5K51.9 Cause of death: ICD-10 — M07.5, M07.5K51.9 2 out of 7 registries used, show all original rules.	465
4. Check minimum number of events None	465
5. Include endpoints None	465
6. Filter based on genotype QC (FinnGen only)	465

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	1853	1058	791
Only index persons	1802	1037	765
Unadjusted period prevalence (%)
Whole population	0.03	0.03	0.02
Only index persons	0.03	0.04	0.03
Median age at first event (years)
Whole population	45.60	44.83	46.65
Only index persons	45.25	44.58	46.16

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	465	302	163
Unadjusted period prevalence (%)	0.09	0.10	0.07
Median age at first event (years)	46.62	44.93	49.77

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
423: Matched controls
4229

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

M07.5*K51.9

ICD-10 Finland

Arthropathy in ulcerative colitis

+∞

323.0

367

A07EC02

ATC

mesalazine; oral, rectal

275.5

323.0

364

208

Kela drug reimbursment

Ulcerative colitis and Crohn's disease

390.8

323.0

377

K51.9

ICD-10 Finland

Ulcerative colitis, unspecified

228.3

321.6

305

K51.5

ICD-10 Finland

Left sided colitis

188.2

283.3

275

A07EC01

ATC

sulfasalazine; oral, rectal

55.6

235.9

294

166

L04AX01

ATC

azathioprine; systemic

54.8

186.9

224

A07EA02

ATC

hydrocortisone; rectal

144.5

184.4

187

K51.3

ICD-10 Finland

Ulcerative (chronic) rectosigmoiditis

145.4

180.5

183

UJF32

NOMESCO Finland

Coloscopy

22.1

168.2

327

565

M07.5

ICD-10 Finland

Arthropathy in ulcerative colitis

+∞

165.8

148

A07EA06

ATC

budesonide; oral, local oral

58.4

143.8

168

K51.8

ICD-10 Finland

Other ulcerative colitis

103.6

126.8

135

H02AB06

ATC

prednisolone; systemic

18.5

122.1

380

1367

K51.1

ICD-10 Finland

Ulcerative (chronic) ileocolitis

111.0

113.4

120

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

16.3

102.5

181

185

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

13.9

99.4

192

238

K51.2

ICD-10 Finland

Ulcerative (chronic) proctitis

83.5

92.6

102

UJF30

NOMESCO Finland

Ileoscopy through colon

13.3

87.0

168

199

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

8.0

83.4

262

712

K51.0

ICD-10 Finland

Ulcerative (chronic) pancolitis

110.8

82.7

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

13.5

73.8

138

146

K51

ICD-10 Finland

Ulcerative colitis

146.5

70.4

L04AB04

ATC

adalimumab; parenteral

31.4

68.8

UJF45

NOMESCO Finland

Flexible sigmoidoscopy with biopsy

12.0

68.4

136

161

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

11.6

59.7

119

138

H02AB07

ATC

prednisone; oral

7.5

58.9

163

328

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

614.1

55.9

UJF14

NOMESCO Finland

Enteroscopy of ileoanal anastomosis

88.5

55.7

J01MA02

ATC

ciprofloxacin; systemic

5.1

53.9

261

1012

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

17.9

47.7

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

16.3

46.5

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

14.5

45.9

K50.9

ICD-10 Finland

Crohn disease, unspecified

24.9

45.2

A07EA01

ATC

prednisolone; rectal

108.0

44.8

326

Kela drug reimbursment

Adalimumab, golimumab, infliximab and ustekinumab (intestinal diseases)

40.1

44.8

L01BB02

ATC

mercaptopurine; oral

47.4

44.7

K50.1

ICD-10 Finland

Crohn disease of large intestine

34.4

44.0

M07.4*K50.9

ICD-10 Finland

Arthropathy in Crohn's disease [regional enteritis]

+∞

39.2

UJF12

NOMESCO Finland

Enteroscopy through intestinal stoma

113.2

38.5

K50.8

ICD-10 Finland

Other Crohn disease

21.3

37.8

D94

ICPC

Chronic enteritis/ulcerative colitis

66.3

36.9

M13.9

ICD-10 Finland

Arthritis, unspecified

7.8

36.8

144

ZX120

NOMESCO Finland

Intravenous

6.7

35.2

183

GD1AA

NOMESCO Finland

Thorax X-ray examination

3.6

34.0

232

1062

P01AB01

ATC

metronidazole; oral, rectal

3.6

33.9

255

1262

K52.9

ICD-10 Finland

Noninfective gastroenteritis and colitis, unspecified

11.7

32.2

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

3.7

31.3

178

689

5561A

ICD-9 Finland

Idiopathic proctocolitis, Ulcerative (chronic) ileocolitis

71.3

29.4

L04AB06

ATC

golimumab; parenteral

23.2

29.3

K52.88

ICD-10 Finland

Other specified noninfective gastroenteritis and colitis

17.6

29.3

56310

ICD-8 Finland

Chronic enteritis and ulcerative colitis, Ulcerative colitis

86.4

29.2

JFH30

NOMESCO Finland

Total colectomy, mucosal proctectomy and ileoanal anastomosis without ileostomy

86.4

29.2

L88

ICPC

Rheumatoid/seropositive arthritis

11.3

28.2

P01BA02

ATC

hydroxychloroquine; oral

5.6

28.0

193

5568X

ICD-9 Finland

Idiopathic proctocolitis, Other ulcerative colitis

57.5

27.6

4AA12

NOMESCO Finland

66.7

27.3

TPH04

NOMESCO Finland

Cathetrisation of vein

3.8

27.2

140

489

M45

ICD-10 Finland

Ankylosing spondylitis

13.1

26.4

M07.3

ICD-10 Finland

Other psoriatic arthropathies

276.6

26.0

JFG00

NOMESCO Finland

Closure of loop enterostomy without resection

57.5

23.3

O99.6

ICD-10 Finland

Diseases of the digestive system complicating pregnancy, childbirth and the puerperium

22.3

22.9

5562A

ICD-9 Finland

Idiopathic proctocolitis, Ulcerative (chronic) proctitis

88.4

22.9

N02AX02

ATC

tramadol; systemic, rectal

2.8

22.6

228

1240

WX002

NOMESCO Finland

Sedation and analgesia

3.6

22.3

118

412

A09

ICD-10 Finland

Other gastroenteritis and colitis of infectious and unspecified origin

3.5

22.0

118

416

A02BC02

ATC

pantoprazole; systemic

2.8

21.2

307

2045

L40.5

ICD-10 Finland

Arthropathic psoriasis

63.4

21.1

M09.2*K51.9

ICD-10 Finland

Juvenile arthritis in ulcerative colitis

+∞

21.0

M25.5

ICD-10 Finland

Pain in joint

2.8

20.4

174

838

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

4.6

19.7

184

NA6BG

NOMESCO Finland

Sacro-iliac joint MRI examination with high intensity magnet

11.5

18.8

K56.6

ICD-10 Finland

Other and unspecified intestinal obstruction

11.4

17.8

K50.0

ICD-10 Finland

Crohn disease of small intestine

11.1

17.5

K83.0

ICD-10 Finland

Cholangitis

26.9

17.1

K56.5

ICD-10 Finland

Intestinal adhesions [bands] with obstruction

20.3

17.1

L04AD01

ATC

ciclosporin; systemic

9.9

17.0

M46.1

ICD-10 Finland

Sacroiliitis, not elsewhere classified

14.2

16.7

A07DA03

ATC

loperamide; oral

7.6

16.5

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

2.5

16.5

181

978

H02AB09

ATC

hydrocortisone; systemic

9.1

15.8

L04AC05

ATC

ustekinumab; parenteral

39.7

15.5

JN3AA

NOMESCO Finland

Abdominal X-ray examination without contrast

6.4

14.8

N02BE01

ATC

paracetamol; systemic, rectal

3.2

14.5

381

3131

1370

FHL

Colonoscopy, whole colon

28.3

14.4

4AB02

NOMESCO Finland

23.2

14.3

L04AA01

ATC

[U] ciclosporin; systemic

11.5

14.2

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

3.7

14.2

203

NF1AE

NOMESCO Finland

Hip joint ultrasound examination

8.3

14.1

A02BC01

ATC

omeprazole; systemic

2.5

14.1

135

668

M01AH01

ATC

celecoxib; oral (coxibs)

2.8

14.0

105

452

UJF92

NOMESCO Finland

Capsular endoscopy

12.0

14.0

NH3EA

NOMESCO Finland

Feet X-ray examination with load

9.5

13.4

NK6QA

NOMESCO Finland

Measurement of bone density from tow or more locations with X-ray

4.6

13.0

110

A06AC01

ATC

ispaghula (psylla seeds); oral

2.5

13.0

118

562

H02AB04

ATC

methylprednisolone; systemic

2.9

12.9

336

JFH11

NOMESCO Finland

Laparoscopic colectomy

133.8

12.5

ZXE10

NOMESCO Finland

More than one and less than three hours

2.2

12.5

173

1011

A02BC05

ATC

esomeprazole; systemic

2.2

12.5

193

1185

A07EC03

ATC

olsalazine; oral

38.8

12.3

M05.8

ICD-10 Finland

Other seropositive rheumatoid arthritis

4.9

12.3

L04AA13

ATC

leflunomide; oral

7.6

12.2

Z2221

NOMESCO Finland

Medical doctor

2.3

12.0

143

780

WX302

NOMESCO Finland

Thoracal epidural anesthesy

5.0

11.9

N02AJ06

ATC

codeine and paracetamol; systemic

2.1

11.9

185

1134

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

3.6

11.5

167

3005

Kela drug reimbursment

Tofacitinib

+∞

11.5

M07.4

ICD-10 Finland

Arthropathy in Crohn disease [regional enteritis]

+∞

11.5

JF1AB

NOMESCO Finland

Passage examination of small bowell with X-ray

13.2

11.2

Z93.2

ICD-10 Finland

Ileostomy status

44.5

11.0

NA3AA

NOMESCO Finland

Lumbar spine X-ray examination without contrast

3.4

10.6

172

NG1DA

NOMESCO Finland

X-ray of knees

10.4

10.6

M01AH05

ATC

etoricoxib; oral

2.0

10.6

272

2000

JFH10

NOMESCO Finland

Total colectomy and ileostomy

112.7

10.5

L04AA29

ATC

tofacitinib; oral

112.7

10.5

M075, K509

ICD-10 Finland

+∞

10.5

JGB50

NOMESCO Finland

Mucosal proctectomy and ileoanal anastomosis

+∞

10.5

L04AB01

ATC

etanercept; parenteral

9.9

10.4

J01DB01

ATC

cefalexin; oral

2.4

10.3

365

3056

Z3231

NOMESCO Finland

Registered nurse

2.2

10.2

126

686

D07AB02

ATC

hydrocortisone butyrate; topical

2.2

10.2

130

722

C10AC01

ATC

colestyramine; oral

7.5

10.1

ZXE20

NOMESCO Finland

More than three and less than five hours

2.8

10.0

272

TNG10

NOMESCO Finland

Puncture of knee

12.6

9.9

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

1.9

9.9

214

1459

Z01.8

ICD-10 Finland

Other specified special examinations

2.2

9.7

109

568

K92.1

ICD-10 Finland

Melaena

5.5

9.7

ZXD10

NOMESCO Finland

Scheduled procedure

2.0

9.6

170

1071

D50.9

ICD-10 Finland

Iron deficiency anaemia, unspecified

3.9

9.6

107

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.9

9.6

239

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.0

9.6

168

1054

L40.0

ICD-10 Finland

Psoriasis vulgaris

5.0

9.5

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

3.4

9.5

152

JFF10

NOMESCO Finland

Loop enterostomy

18.0

9.5

K51.4

ICD-10 Finland

Inflammatory polyps

+∞

9.4

M075, L405

ICD-10 Finland

+∞

9.4

M075, K515

ICD-10 Finland

+∞

9.4

M06.9

ICD-10 Finland

Rheumatoid arthritis, unspecified

5.5

9.4

TNH11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in ankle joint or foot joint

9.8

9.4

JAH00

NOMESCO Finland

Laparotomy

7.6

9.3

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.6

9.2

291

M01AC06

ATC

meloxicam; systemic, rectal

1.9

9.1

165

1045

N03AX16

ATC

pregabalin; oral

2.1

9.0

115

630

H04.10

ICD-10 Finland

Dry eye syndrome

3.0

8.8

191

JJ2AT

NOMESCO Finland

Biopsy of liver with ultrasound guidance

6.8

8.8

UJG02

NOMESCO Finland

Proctoscopy

6.8

8.8

B01AB05

ATC

enoxaparin; parenteral

2.1

8.8

122

696

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.0

8.7

195

M05BA04

ATC

alendronic acid; oral

4.0

8.7

JFA98

NOMESCO Finland

Other transluminal endoscopic local operation on intestine

10.3

8.6

JH1CG

NOMESCO Finland

Extensive MRI of perianal area

28.1

8.5

JFH33

NOMESCO Finland

Total colectomy, mucosal proctectomy, ileoanal anastomosis and ileostomy

91.8

8.4

AA1AD

NOMESCO Finland

CT of head and brain

2.2

8.4

495

M09.1*K50.9

ICD-10 Finland

Juvenile arthritis in Crohn's disease [regional enteritis]

+∞

8.4

56399

ICD-8 Finland

Chronic enteritis and ulcerative colitis, Other

+∞

8.4

JFG73

NOMESCO Finland

Excision of ileal pelvic pouch

+∞

8.4

TND11

NOMESCO Finland

Injection of diagnostic or therapeutic substance in joint, wrist or hand

9.7

8.3

JHA00

NOMESCO Finland

Anal or perianal incision

7.3

8.3

R03AC02

ATC

salbutamol; inhalant

1.8

8.2

234

1712

ZY020

NOMESCO Finland

Telephone, letter or other consultation without direct patient contact

3.3

8.2

134

R4110

NOMESCO Finland

Physiotherapy

2.0

8.2

115

656

JKE98

NOMESCO Finland

Other transduodenal endoscopic operation on bile duct or ampulla of Vater

9.2

8.1

K50

ICD-10 Finland

Crohn disease [regional enteritis]

22.5

8.0

E0000UV

ATC

1.8

8.0

172

1144

M46.9

ICD-10 Finland

Inflammatory spondylopathy, unspecified

8.0

7.9

NK5AT

NOMESCO Finland

Joint injection with ultrasound guidance not elsewhere classified

13.4

7.9

K56.7

ICD-10 Finland

Ileus, unspecified

9.7

7.8

ZXX01

NOMESCO Finland

Extent of proceudre, 1 unit

15.4

7.8

M02.9

ICD-10 Finland

Reactive arthropathy, unspecified

7.7

D07AC01

ATC

betamethasone; topical

1.9

7.6

144

914

M01AH02

ATC

rofecoxib; oral

2.5

7.6

261

WX404

NOMESCO Finland

Intravenous generell anesthesy

2.1

7.5

541

K44.9

ICD-10 Finland

Diaphragmatic hernia without obstruction or gangrene

3.3

7.5

121

J05AB11

ATC

valaciclovir; oral

2.4

7.4

280

Z3226

NOMESCO Finland

Physiotherapist

2.1

7.3

459

M073, K519

ICD-10 Finland

+∞

7.3

JFF11

NOMESCO Finland

Laparoscopic loop enterostomy

+∞

7.3

ND2BA

NOMESCO Finland

Hand and fingers extensive X-ray examination

6.0

7.3

J01MA12

ATC

levofloxacin; systemic

2.2

7.3

400

WX408

NOMESCO Finland

General anesthesy, balanced

1.9

7.2

122

741

GD1PA

NOMESCO Finland

X-ray examination of the lungs in one projection

3.3

7.2

113

A05AA02

ATC

ursodeoxycholic acid; oral

6.2

7.1

K60.3

ICD-10 Finland

Anal fistula

6.2

7.1

WX110

NOMESCO Finland

Local anesthesy

1.8

7.1

301

2446

M06.0

ICD-10 Finland

Seronegative rheumatoid arthritis

5.1

7.1

WVA20

NOMESCO Finland

Medicine administration

5.6

7.0

ZXE00

NOMESCO Finland

One hour or less

1.8

7.0

171

1175

3AC01

NOMESCO Finland

9.5

6.8

JN3AD

NOMESCO Finland

Abdominal CT examination

2.9

6.8

141

M13.0

ICD-10 Finland

Polyarthritis, unspecified

7.4

6.8

Z71.3

ICD-10 Finland

Dietary counselling and surveillance

3.2

6.7

108

TNX00

NOMESCO Finland

Puncture and needle biopsy of soft tissue, unspecified region

4.5

6.6

R50.9

ICD-10 Finland

Fever, unspecified

2.2

6.6

331

K56.0

ICD-10 Finland

Paralytic ileus

12.5

6.6

E86

ICD-10 Finland

Volume depletion

8.9

6.6

JF1CG

NOMESCO Finland

Extensive MRI of small bowel

8.9

6.6

NG1AA

NOMESCO Finland

Knee X-ray examination without contrast

2.5

6.6

218

M17.5

ICD-10 Finland

Other secondary gonarthrosis

10.2

6.6

Z04.8

ICD-10 Finland

Examination and observation for other specified reasons

2.3

6.5

277

NDG30

NOMESCO Finland

Fusion of wrist, total

70.9

6.4

NA6AA

NOMESCO Finland

Sacro-iliac joint X-ray examination

14.6

6.4

NF1AA

NOMESCO Finland

Hip X-ray examination

3.2

6.4

106

XX9XE

NOMESCO Finland

Other ultrasound examination

8.3

6.4

N05CF01

ATC

zopiclone; oral

1.8

6.3

131

845

M03BX02

ATC

tizanidine; oral

1.7

6.3

276

2222

UJF34

NOMESCO Finland

Left colonoscopy

18.3

6.3

NA3BG

NOMESCO Finland

Lumbar spine MRI examination with high intensity magnet

2.4

6.3

231

M01AX17

ATC

nimesulide; oral

1.9

6.3

584

K63.3

ICD-10 Finland

Ulcer of intestine

+∞

6.3

M07.6

ICD-10 Finland

Other enteropathic arthropathies

+∞

6.3

6960A

ICD-9 Finland

Psoriasis and similar disorders, Psoriatic arthropathy

+∞

6.3

5560A

ICD-9 Finland

Idiopathic proctocolitis, Ulcerative (chronic) enterocolitis

27.1

6.2

JF1BD

NOMESCO Finland

Very extensive small bowel CT

27.1

6.2

JF1DG

NOMESCO Finland

Small bowel very extensive MRI with with high intensity magnet

10.2

6.1

K61.0

ICD-10 Finland

Anal abscess

5.7

6.0

WZA10

NOMESCO Finland

Long statement of health and health related matters

6.2

6.0

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

3.2

6.0

Mortality – FinRegistry

↥

Association

Association between endpoint ULCER_ARTHR and mortality.

Females

Parameter	HR [95% CI]	p-value
ULCER_ARTHR	1.403 [1.1, 1.79]	0.006
Birth year	0.996 [0.99, 1.0]	0.305

During the follow-up period (1.1.1998 — 31.12.2019), 62 out of 907 females with ULCER_ARTHR died.

Males

Parameter	HR [95% CI]	p-value
ULCER_ARTHR	1.167 [0.92, 1.49]	0.212
Birth year	0.991 [0.98, 1.0]	0.057

During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 698 males with ULCER_ARTHR died.

Mortality risk

Mortality risk for people of age

years, who have ULCER_ARTHR.

N-year risk	Females	Males
1	0.127%	0.177%
5	0.763%	1.472%
10	1.952%	3.667%
15	3.853%	7.007%
20	6.948%	12.123%

Relationships between endpoints

↥

Index endpoint: ULCER_ARTHR – Arthropathy in ulcerative colitis

GWS hits: 1

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	ULCER_ARTHR
CONTROL_EXCLUDE	PSOR_ENTE_ARTHR
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	M075
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	M075
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Arthropathy in ulcerative colitis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints