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This is a non-core endpoint: only basic statistics are computed.

See its core counterpart CD2_INSITU_COLON_EXALLC for full statistics.

Carcinoma in situ of colon

CD2_INSITU_COLON

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

  • not C3_COLON
514270

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 D01.0&
  • Hospital discharge: ICD-9 2303
  • Cause of death: ICD-10 D01.0&
  • Cause of death: ICD-9 2303
  • Cancer registry: Topography ICD-O-3 C18
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 2

3 out of 7 registries used, show all original rules.

438

4. Check minimum number of events

None

438

5. Include endpoints

None

438

6. Filter based on genotype QC (FinnGen only)

438

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF9
Parent code in ICD-10
D01
Name in latin
Carcinoma in situ ani

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 438 175 263
Unadjusted period prevalence (%) 0.09 0.06 0.12
Median age at first event (years) 71.38 71.88 71.04

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
393
Matched controls
3928
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UJF32
NOMESCO Finland
Coloscopy
8.8
84.8
262
728
D12.0
ICD-10 Finland
Benign neoplasm: Caecum
22.6
58.3
86
48
D12.5
ICD-10 Finland
Benign neoplasm: Sigmoid colon
15.2
57.2
99
85
D12.6
ICD-10 Finland
Benign neoplasm: Colon, unspecified
12.0
53.5
104
114
JFA15
NOMESCO Finland
Endoscopic polypectomy in colon
11.1
52.6
107
128
JFB31
NOMESCO Finland
Laparoscopic right hemicolectomy
37.5
51.9
66
21
D12.2
ICD-10 Finland
Benign neoplasm: Ascending colon
15.4
48.2
82
66
8263/2-C18.0
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of cecum
+∞
43.5
41
*
C187, 8211, 2
ICD-O-3
NA
+∞
42.5
40
*
JFA98
NOMESCO Finland
Other transluminal endoscopic local operation on intestine
17.2
36.7
59
40
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
6.5
35.3
101
198
D37.4
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Colon
20.2
35.2
53
30
8263/2-C18.7
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of sigmoid colon
+∞
31.7
30
*
C189, 8211, 2
ICD-O-3
NA
+∞
31.7
30
*
K63.5
ICD-10 Finland
Polyp of colon
30.3
30.9
41
15
WX402
NOMESCO Finland
General anaesthesia
4.5
30.6
128
381
D12.3
ICD-10 Finland
Benign neoplasm: Transverse colon
12.3
28.8
53
49
WX302
NOMESCO Finland
Thoracal epidural anesthesy
7.1
25.6
66
109
8263/2-C18.9
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of colon, NOS
+∞
25.3
24
*
C180, 8211, 2
ICD-O-3
NA
+∞
25.3
24
*
D12.4
ICD-10 Finland
Benign neoplasm: Descending colon
13.3
24.4
43
36
B01AB05
ATC
enoxaparin; parenteral
3.0
22.1
179
860
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
5.8
21.9
65
129
C187, 8148, 2
ICD-O-3
NA
+∞
21.0
20
*
D12.8
ICD-10 Finland
Benign neoplasm: Rectum
6.8
20.7
54
90
C189, 8148, 2
ICD-O-3
NA
+∞
18.9
18
*
UJF32
SPAT
NA
12.3
18.9
34
30
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
3.2
18.6
118
466
8211/2-C18.2
ICD-O-3
Tubular adenocarcinoma in situ of ascending colon
+∞
16.8
16
*
C180, 8148, 2
ICD-O-3
NA
+∞
16.8
16
*
JFA15
SPAT
NA
35.0
15.9
20
6
D01.0
ICD-10 Finland
Carcinoma in situ: Colon
166.3
15.6
16
*
C20.91
ICD-10 Finland
Malignant tumor of the rectum invasive carcinoma
7.3
15.4
37
55
UJF30
NOMESCO Finland
Ileoscopy through colon
3.7
15.0
71
223
TPH07
NOMESCO Finland
Cathetrisation of artery
3.4
14.8
80
277
8263/2-C18.2
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of ascending colon
+∞
14.7
14
*
B01AB10
ATC
tinzaparin; parenteral
4.2
14.0
56
151
D12.7
ICD-10 Finland
Benign neoplasm: Rectosigmoid junction
15.8
13.2
21
14
8140/3-C20.9
ICD-O-3
Adenocarcinoma, NOS, of rectum, NOS
7.3
12.7
30
44
C18.72
ICD-10 Finland
Malignant tumor of sigmoid carcinoma of adenoma
48.2
11.9
14
*
C20.90
ICD-10 Finland
Malignant tumor of the rectum without histology
9.4
11.9
24
27
8140/2-C18.7
ICD-O-3
Adenocarcinoma in situ, NOS, of sigmoid colon
+∞
11.5
11
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
11.2
145
820
XF603
NOMESCO Finland
Direct intraarterial blood pressure measurement
5.3
10.9
33
67
C18.71
ICD-10 Finland
Malignant tumor of the sigmoid invasive carcinoma
9.6
10.6
21
23
C18.70
ICD-10 Finland
Malignant tumor of the sigmoid without histology
10.5
10.6
20
20
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
3.5
10.2
48
149
JFB44
NOMESCO Finland
Laparoscopic left hemicolectomy
20.7
9.9
14
7
JN4AD
NOMESCO Finland
Body CT examination
3.0
9.7
56
203
C184, 8211, 2
ICD-O-3
NA
+∞
9.4
9
*
C186, 8211, 2
ICD-O-3
NA
+∞
9.4
9
*
C184, 8148, 2
ICD-O-3
NA
+∞
9.4
9
*
C188, 8211, 2
ICD-O-3
NA
+∞
9.4
9
*
JFB47
NOMESCO Finland
Laparoscopic resection of sigmoid colon
16.1
9.1
14
9
130
Kela drug reimbursment
Malignant tumour
2.9
8.6
54
206
JGB03
NOMESCO Finland
Partial proctectomy with partial excision of mesorectum
20.6
8.5
12
6
JFB21
NOMESCO Finland
Laparoscopic ileocaecal resection
91.9
8.4
9
*
C18.00
ICD-10 Finland
Malignant tumor of the caecum without histology
13.1
8.4
14
11
C182, 8148, 2
ICD-O-3
NA
+∞
8.4
8
*
JFB51
NOMESCO Finland
Other laparoscopic resection of colon
+∞
8.4
8
*
D64.9
ICD-10 Finland
Anaemia, unspecified
2.6
8.3
62
264
L01BC06
ATC
capecitabine; oral
4.0
8.2
32
86
JN4BD
NOMESCO Finland
Extensive body CT
2.5
8.1
68
305
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
3.7
8.1
34
97
K62.5
ICD-10 Finland
Haemorrhage of anus and rectum
3.7
8.0
34
98
WX600
NOMESCO Finland
Single shot through catheter
8.0
8.0
17
22
JFA52
NOMESCO Finland
Other endoscopic haemostatic procedure in colon
18.8
7.6
11
6
C03CA01
ATC
furosemide; systemic
1.9
7.4
137
868
C18.20
ICD-10 Finland
Malignant tumor of the ascending colon without histology
11.2
7.3
13
12
JFB30
NOMESCO Finland
Right hemicolectomy
6.9
6.9
16
24
R4110
NOMESCO Finland
Physiotherapy
1.9
6.7
123
768
8263/2-C18.4
ICD-O-3
Adenocarcinoma in situ in tubulovillous adenoma of transverse colon
+∞
6.3
6
*
N02BE01
ATC
paracetamol; systemic, rectal
2.1
6.2
342
3007
8140/3-C19.9
ICD-O-3
Adenocarcinoma, NOS, of rectosigmoid junction
12.8
6.1
10
8

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: CD2_INSITU_COLON – Carcinoma in situ of colon

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).