No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
346 |
4. Check minimum number of eventsNone |
346 |
5. Include endpointsNone |
346 |
6. Filter based on genotype QC (FinnGen only) |
333 |
Control definitions (FinnGen only)
- Control exclude
- D3_NUTRIANAEMIA
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D50-D53
- Name in latin
- Anaemia ex deficientia folatorum
Similar endpoints
↥List of similar endpoints to
Folate deficiency anaemia
based on the number of shared cases.
Similar with more cases:
- Nutritional anaemias
- Anaemias
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 2872 | 1482 | 1356 |
| Only index persons | 2205 | 1156 | 1049 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.04 | 0.04 | 0.04 |
| Only index persons | 0.04 | 0.04 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 72.84 | 75.31 | 70.14 |
| Only index persons | 72.08 | 74.17 | 69.79 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 333 | 131 | 202 |
| Unadjusted period prevalence (%) | 0.07 | 0.05 | 0.09 |
| Median age at first event (years) | 67.51 | 61.97 | 71.11 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 346
- Matched controls
- 3460
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
1540.4
267.1
226
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
44.5
133.2
82
24
D52.0
ICD-10 Finland
Dietary folate deficiency anaemia
+∞
83.8
77
*
D64.9
ICD-10 Finland
Anaemia, unspecified
8.9
78.3
124
204
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.4
54.3
187
619
B03BA03
ATC
hydroxocobalamin; parenteral
10.1
47.9
59
69
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
112.7
37.6
40
*
D52.8
ICD-10 Finland
Other folate deficiency anaemias
+∞
30.7
29
*
E87.6
ICD-10 Finland
Hypokalaemia
7.9
26.4
38
53
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.8
24.7
41
67
B81
ICPC
Anaemia vit B12/folate deficiency
9.3
24.0
30
35
AA1AD
NOMESCO Finland
CT of head and brain
3.1
22.9
147
664
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.9
22.5
80
250
XW000
NOMESCO Finland
Bone marrow biopsy
6.2
22.2
40
71
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.8
21.6
54
129
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.2
21.0
113
457
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
25.2
20.3
28
12
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.6
18.3
37
73
JN4AD
NOMESCO Finland
Body CT examination
3.8
18.0
62
188
C03CA01
ATC
furosemide; systemic
2.6
17.1
164
884
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.2
17.1
80
295
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
4.4
16.1
44
112
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.9
15.4
89
368
L28
ICPC
Limited function/disability (L)
2.8
14.9
92
394
JN3AD
NOMESCO Finland
Abdominal CT examination
3.3
14.8
62
212
E86
ICD-10 Finland
Volume depletion
6.7
14.8
24
38
N05AH04
ATC
quetiapine; oral
2.9
14.4
82
335
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
14.4
68
250
R53
ICD-10 Finland
Malaise and fatigue
2.6
14.2
116
570
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
14.1
144
784
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
13.7
194
1215
107
Kela drug reimbursment
Pernicious anaemia
+∞
13.6
13
*
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.8
13.3
79
330
WW500
NOMESCO Finland
Blood transfusion
4.6
13.0
32
75
UJF30
NOMESCO Finland
Ileoscopy through colon
3.3
12.5
52
177
A02BC02
ATC
pantoprazole; systemic
2.4
11.9
253
1836
D52.1
ICD-10 Finland
Drug-induced folate deficiency anaemia
+∞
11.5
11
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
11.4
51
181
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
17.8
11.3
17
10
SPAT1254
SPAT
Administration of medicine
2.7
11.2
70
298
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
113.3
10.5
11
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
10.4
121
679
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
24.2
10.3
14
6
H02AB06
ATC
prednisolone; systemic
2.1
10.0
183
1215
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.6
10.0
67
295
A04
ICPC
Weakness/tiredness general
2.6
9.9
65
283
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.2
9.8
40
134
N06AX11
ATC
mirtazapine; oral
2.1
9.7
130
767
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.5
9.7
67
299
FB1BD
NOMESCO Finland
Extensive CT examination of arteria pulmonalis
3.4
9.7
37
119
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.1
9.5
132
788
N03AG01
ATC
valproic acid; systemic, rectal
3.9
9.5
29
80
UJF32
NOMESCO Finland
Coloscopy
2.2
9.2
106
588
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
5.0
9.2
20
42
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
9.2
33
102
A06AD11
ATC
lactulose; oral
2.4
9.1
76
369
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.5
9.1
65
294
A28
ICPC
Limited function/disability NOS
2.3
9.0
83
420
K92.1
ICD-10 Finland
Melaena
3.6
8.7
29
85
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.3
8.7
34
111
A41.9
ICD-10 Finland
Sepsis, unspecified
3.9
8.5
25
67
28120
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Folic acid deficiency anaemia
+∞
8.4
8
*
SPAT1216
SPAT
Assessment of functional ability
2.3
8.3
73
361
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.6
8.3
20
46
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.0
8.2
111
651
D50.8
ICD-10 Finland
Other iron deficiency anaemias
17.7
8.1
12
7
F10.25
ICD-10 Finland
Alcohol dependence continuous use
9.3
8.1
16
18
F03
ICD-10 Finland
Unspecified dementia
3.6
8.1
27
79
N19
ICD-10 Finland
Unspecified kidney failure
3.8
8.0
25
70
R50.9
ICD-10 Finland
Fever, unspecified
2.3
7.9
65
312
S82.8
ICD-10 Finland
Fractures of other parts of lower leg
4.4
7.8
20
48
Z02.7
ICD-10 Finland
Issue of medical certificate
3.1
7.8
34
118
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
7.8
88
482
M04AA01
ATC
allopurinol; systemic
2.3
7.8
66
322
NH1AA
NOMESCO Finland
Ankle X-ray examination without contrast
3.4
7.7
28
87
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
7.7
50
216
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.3
7.6
67
331
D51.0
ICD-10 Finland
Vitamin B12deficiency anaemia due to intrinsic factor deficiency
81.8
7.4
8
*
GD1AD
NOMESCO Finland
Thorax CT examination
3.2
7.3
29
95
D64.8
ICD-10 Finland
Other specified anaemias
9.7
7.3
14
15
N30.0
ICD-10 Finland
Acute cystitis
2.3
7.2
57
269
N05AX08
ATC
risperidone; systemic
2.6
7.2
43
178
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
4.4
7.1
18
43
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.6
7.1
42
173
SPAT1229
SPAT
Assessment of need for aid
2.7
7.1
38
149
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.4
6.9
50
227
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
4.4
6.8
17
40
I50.9
ICD-10 Finland
Heart failure, unspecified
2.1
6.8
74
397
SPAT1262
SPAT
Handing over of treatment supplies
2.1
6.8
70
368
J01MA02
ATC
ciprofloxacin; systemic
1.8
6.7
146
990
A99
ICPC
Disease/condition unspecnature/site
2.7
6.7
37
147
UJF92
NOMESCO Finland
Capsular endoscopy
9.0
6.6
13
15
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.1
6.6
66
343
N05BA12
ATC
alprazolam; oral
2.6
6.6
41
173
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
2.3
6.5
54
260
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
6.4
131
868
N05BA04
ATC
oxazepam; oral
1.9
6.4
96
577
K74.6
ICD-10 Finland
Other and unspecified cirrhosis of liver
8.4
6.4
13
16
R60.0
ICD-10 Finland
Localized oedema
2.3
6.3
51
242
N06AB04
ATC
citalopram; systemic
2.0
6.3
75
415
SPAT1255
SPAT
Intravenous administration of medicine
3.0
6.3
29
104
A46
ICD-10 Finland
Erysipelas
2.1
6.3
63
327
K44.9
ICD-10 Finland
Diaphragmatic hernia without obstruction or gangrene
2.7
6.3
33
128
L98.4
ICD-10 Finland
Chronic ulcer of skin, not elsewhere classified
5.5
6.2
17
32
R11
ICD-10 Finland
Nausea and vomiting
2.6
6.2
37
153
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.1
6.1
25
84
ZXD05
NOMESCO Finland
Urgent procedure
1.8
6.1
111
709
GD1BA
NOMESCO Finland
Extensive X-ray examination of thorax
10.3
6.1
11
11
M10.9
ICD-10 Finland
Gout, unspecified
2.7
6.1
33
130
L01BA01
ATC
methotrexate; systemic
4.0
6.1
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
168
354
8.28
85.46
2.8
2.4
26.29
24.18
%
0.58
153
306
130
221
8.82
79.91
5.0
2.9
70.58
68.62
e9/l
0.16
103
177
169
383
7.67
79.32
2.9
2.3
1.95
2.21
g/l
5.83
160
356
152
310
7.96
78.99
4.6
2.9
2.10
1.75
%
1.92
135
286
222
673
7.41
76.75
2.5
1.6
16.79
20.46
nmol/l
1.64
196
561
173
414
7.36
76.49
3.0
2.3
12.82
13.40
umol/l
0.26
165
383
96
123
10.42
74.10
1.9
2.1
1.52
1.54
g/l
0.05
78
109
208
649
6.53
67.79
3.4
1.9
3.05
2.87
mg/l
0.56
188
560
133
299
6.60
60.95
4.4
4.5
274.80
242.82
u/l
0.70
127
283
63
68
11.10
54.46
1.7
1.6
—
—
—
0
0
106
227
6.29
50.21
2.4
2.8
64.31
66.33
g/l
1.39
100
204
232
1054
4.65
41.76
4.4
2.5
296.46
147.71
ug/l
5.12
217
967
229
1113
4.13
35.50
3.0
2.0
79.07
94.05
pmol/l
6.63
169
585
58
97
6.98
34.49
2.1
4.1
43.47
40.49
mg/l
0.18
42
79
58
97
6.98
34.49
2.1
4.1
74.67
128.51
mg/l
0.36
43
78
81
187
5.35
34.43
3.0
2.3
11.08
11.09
g/l
0.00
74
164
47
62
8.62
34.42
3.3
3.0
32.93
35.13
umol/l
0.18
42
53
91
255
4.49
30.29
2.6
2.3
0.19
0.21
g/l
1.99
80
236
31
29
11.64
29.07
2.9
2.2
32.97
33.72
pg
0.30
31
29
138
549
3.52
27.43
2.7
1.7
1252.74
1176.05
nmol/l
0.38
110
418
58
125
5.37
26.32
2.8
2.1
2.42
1.14
ug/l
0.80
53
106
222
1210
3.33
25.66
9.9
5.9
24.39
26.90
%
2.09
211
1133
235
1327
3.40
25.54
11.0
6.9
1.19
1.21
mmol/l
2.48
192
1137
218
1178
3.30
25.52
7.1
4.7
31.50
35.27
g/l
14.13
207
1093
119
452
3.49
25.13
3.0
2.0
—
—
—
0
0
138
583
3.27
24.39
2.2
1.7
407.38
434.83
pmol/l
0.47
114
477
216
1199
3.13
23.41
9.0
5.6
60.98
58.05
%
2.58
206
1128
240
1419
3.26
23.19
10.8
6.4
13.46
11.60
umol/l
0.54
229
1339
193
1021
3.01
22.54
3.1
2.2
67.62
76.81
nmol/l
3.62
176
896
84
279
3.66
21.49
2.2
1.7
1.88
1.51
%
2.76
70
244
68
200
3.99
20.71
2.3
1.7
—
—
—
0
0
33
52
6.91
20.48
4.8
2.8
13.47
16.00
%
2.33
23
27
212
1239
2.84
19.61
9.8
6.2
1.19
1.21
mmol/l
2.99
202
1116
237
1474
2.93
19.35
14.6
9.1
4.71
4.22
e9/l
1.90
217
1298
223
1355
2.82
18.83
18.3
16.2
1.23
1.29
inr
0.55
78
376
62
186
3.84
18.25
4.0
3.1
2.55
1.84
mmol/l
0.65
46
138
28
42
7.17
18.13
4.1
2.0
2.07
1.54
mmol/l
1.97
28
42
47
117
4.49
17.76
2.1
1.7
3.83
3.52
g/l
0.74
41
106
47
117
4.49
17.76
2.1
1.7
7.12
7.34
g/l
0.30
41
106
47
117
4.49
17.76
2.1
1.7
—
—
—
0
0
38
81
5.15
17.27
1.7
1.2
—
—
—
0
0
44
107
4.57
17.10
2.0
1.7
10.43
10.83
g/l
0.21
37
95
44
108
4.52
16.90
2.1
1.8
3.10
3.08
g/l
0.04
37
97
73
265
3.22
15.91
6.5
3.7
1.03
1.57
mmol/l
0.47
64
205
156
844
2.54
15.89
3.0
2.1
605.97
262.54
u/l
0.39
147
787
163
904
2.52
15.70
4.0
3.1
2710.49
1454.12
ng/l
2.09
139
785
70
256
3.17
15.02
6.8
6.7
2.06
1.48
mmol/l
0.98
70
246
107
496
2.68
14.84
1.3
1.2
2.03
1.43
u/ml
0.34
36
124
80
322
2.93
14.49
2.7
1.9
—
—
—
0
0
153
852
2.43
14.28
4.3
2.4
53.34
63.87
u/l
1.01
143
792
22
33
7.05
14.19
4.3
3.6
55.36
61.18
%
0.88
22
33
28
54
5.55
14.15
9.0
3.9
4.94
5.01
kpa
0.18
28
54
58
196
3.35
14.12
8.2
4.2
1.20
1.23
mmol/l
2.15
50
172
79
325
2.85
13.68
2.7
1.9
—
—
—
0
0
49
152
3.59
13.60
9.0
6.9
23.88
24.53
mmol/l
0.47
49
152
29
60
5.18
13.58
2.9
1.8
—
—
—
0
0
236
1618
2.44
13.37
10.3
4.9
6.93
6.75
mmol/l
0.63
227
1527
24
44
5.79
12.77
3.2
1.8
—
—
—
0
0
33
81
4.40
12.61
1.4
1.6
187.95
271.41
ug/g
1.41
19
45
55
193
3.20
12.54
3.3
3.8
98.34
81.19
ng/l
0.57
44
172
37
100
4.02
12.47
2.3
2.0
1.24
0.77
g/l
0.28
30
90
249
1785
2.41
12.18
6.9
4.5
8158.33
917.66
e6/l
—
9
32
26
55
5.03
11.86
1.6
1.5
—
—
—
0
0
48
161
3.30
11.76
2.1
1.7
—
—
—
0
0
132
742
2.26
11.52
4.3
2.8
2562.99
8467.50
umol/l
1.28
117
634
27
61
4.72
11.41
3.0
1.8
—
—
—
0
0
68
284
2.74
11.31
7.6
3.2
—
—
—
0
0
145
857
2.19
11.09
4.8
3.2
39.81
33.24
u/l
1.13
137
811
162
1003
2.16
10.98
5.3
3.2
—
—
—
0
0
185
1209
2.14
10.86
3.8
2.6
—
—
—
0
0
20
36
5.84
10.82
2.9
1.6
—
—
—
0
0
234
1683
2.21
10.62
6.2
3.1
96.43
50.02
u/l
4.47
220
1561
143
859
2.13
10.33
5.0
3.3
28.90
124.33
e6/l
0.68
118
661
21
42
5.26
10.18
2.5
1.7
—
—
—
0
0
148
914
2.08
9.82
3.0
3.4
2.31
2.35
mmol/l
1.91
129
797
190
1288
2.05
9.75
7.7
5.0
0.00
0.00
estimate
-0.00
57
236
257
1951
2.23
9.73
6.9
4.0
23.66
12.87
mm/h
11.14
241
1772
28
74
4.03
9.71
1.3
2.3
—
—
—
0
0
190
1292
2.04
9.62
6.2
3.7
0.00
0.00
estimate
0.50
61
257
21
45
4.90
9.42
2.5
1.6
—
—
—
0
0
190
1301
2.02
9.34
6.2
3.7
0.00
0.00
estimate
-0.00
56
225
75
359
2.39
9.29
9.2
6.7
104.24
104.08
mmol/l
0.10
75
359
170
1123
2.01
9.21
7.8
3.9
39.13
43.48
ng/l
0.25
153
838
22
52
4.45
8.79
2.5
1.6
—
—
—
0
0
46
178
2.83
8.76
2.4
1.4
—
—
—
0
0
19
40
4.97
8.69
2.6
1.7
—
—
—
0
0
31
97
3.41
8.44
2.2
1.7
35.23
37.42
g/l
0.71
24
86
66
314
2.36
8.24
5.7
3.0
15.14
8.87
umol/l
0.49
54
277
20
32
6.57
8.14
3.7
3.1
4.29
4.74
e9/l
0.27
20
32
38
140
2.93
7.90
3.6
2.4
0.75
0.66
%
0.40
38
140
18
40
4.69
7.74
1.3
1.2
—
—
—
0
0
247
1938
1.96
7.32
4.8
3.7
15.30
14.84
pmol/l
1.77
230
1717
35
129
2.91
7.27
1.5
1.2
2896.16
139.87
u/ml
0.93
30
116
124
783
1.91
7.25
5.0
3.2
0.57
0.42
e6/l
0.65
100
588
38
147
2.78
7.23
3.6
2.4
1.36
1.17
%
0.53
38
147
115
710
1.93
7.19
7.5
4.0
0.00
0.00
estimate
-0.00
55
227
17
40
4.42
6.83
1.7
1.4
—
—
—
0
0
17
40
4.42
6.83
2.3
1.9
—
—
—
0
0
17
40
4.42
6.83
2.3
1.9
—
—
—
0
0
23
68
3.55
6.82
1.6
1.3
—
—
—
0
0
10
6
17.11
6.78
1.6
1.3
—
—
iu/ml
—
0
0
29
102
3.01
6.54
3.3
2.0
—
—
—
0
0
34
131
2.77
6.52
5.9
4.1
22.58
23.60
mmol/l
0.89
34
126
95
567
1.93
6.48
2.3
1.6
1.22
1.34
mg/l
0.24
79
448
29
107
2.87
6.02
1.3
2.3
36.64
39.85
u/l
0.27
22
96
15
27
5.76
5.75
3.3
1.6
—
—
—
0
0
26
93
2.94
5.71
3.1
1.8
—
—
—
0
0
13
20
6.71
5.61
3.5
1.6
—
—
—
0
0
143
1009
1.71
5.45
7.2
3.9
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
24
85
2.96
5.36
6.0
2.4
0.30
0.41
u/ml
0.91
12
49
125
856
1.72
5.28
4.0
3.9
12.26
10.15
mg/mmol
0.18
73
549
11
15
7.53
5.18
1.1
1.1
—
—
—
0
0
11
15
7.53
5.18
1.1
1.1
—
—
—
0
0
86
532
1.82
5.13
3.0
3.2
2.46
2.45
mmol/l
0.81
80
468
8
6
13.60
5.10
1.3
1.0
—
—
—
0
0
25
94
2.79
5.03
3.0
3.1
—
—
—
0
0
11
16
7.06
4.99
2.8
2.1
—
—
—
0
0
98
636
1.75
4.96
3.6
2.4
—
—
—
0
0
16
38
4.36
4.89
1.2
1.2
404.50
280.65
u/ml
—
8
17
279
2403
1.83
4.74
5.8
4.5
2.03
1.97
mu/l
0.38
268
2156
13
26
5.15
4.68
1.0
1.1
—
—
—
0
0
58
326
1.94
4.63
9.9
8.6
1.40
1.24
mmol/l
0.06
46
264
9
12
7.67
4.38
3.8
1.8
—
—
—
0
0
7
6
11.87
4.29
2.6
1.3
—
—
—
0
0
12
25
4.93
4.22
2.4
2.1
—
—
—
0
0
12
25
4.93
4.22
2.4
2.1
—
—
—
0
0
12
25
4.93
4.22
2.4
2.1
—
—
—
0
0
9
13
7.08
4.19
3.8
1.8
—
—
—
0
0
13
30
4.46
4.17
1.9
1.3
—
—
—
0
0
12
26
4.74
4.09
1.7
1.3
82.83
71.00
%
—
6
18
13
31
4.32
4.05
2.1
1.6
—
—
—
0
0
52
295
1.90
4.03
2.7
4.6
5.32
24.50
ug/l
0.71
46
239
7
7
10.17
4.02
2.0
1.4
24.26
32.43
umol/l
—
7
7
12
27
4.57
3.97
2.2
1.6
—
—
—
0
0
17
59
2.98
3.96
1.9
1.5
—
—
—
0
0
13
32
4.18
3.94
2.1
1.6
—
—
—
0
0
13
32
4.18
3.94
2.1
1.6
—
—
—
0
0
13
32
4.18
3.94
2.1
1.6
—
—
—
0
0
13
32
4.18
3.94
2.1
1.6
—
—
—
0
0
13
32
4.18
3.94
2.1
1.6
—
—
—
0
0
76
489
1.71
3.89
3.2
2.8
3.13
1.05
e6/l
1.91
51
283
294
2632
1.78
3.63
36.8
15.2
25.30
25.81
mg/l
0.12
281
2102
11
26
4.33
3.53
2.3
2.0
—
—
—
0
0
6
6
10.15
3.51
1.0
2.7
—
—
—
0
0
17
64
2.74
3.45
4.9
2.9
1.80
1.51
mmol/l
0.72
17
64
9
18
5.10
3.39
1.8
1.2
—
—
—
0
0
9
18
5.10
3.39
3.8
1.7
—
—
—
0
0
11
28
4.02
3.31
1.6
1.7
—
—
—
0
0
11
28
4.02
3.31
1.6
1.7
—
—
—
0
0
47
276
1.81
3.28
11.4
9.6
107.94
121.38
g/l
3.39
47
271
179
1452
1.48
3.24
3.2
2.7
—
—
—
0
0
278
2474
1.63
3.24
7.2
6.0
39.24
40.33
mmol/mol
1.22
258
2295
11
30
3.75
3.11
2.3
1.9
—
—
—
0
0
64
417
1.66
3.10
1.4
1.3
37.62
35.38
iu/ml
0.04
21
137
8
16
5.09
3.07
1.4
1.2
—
—
—
0
0
8
16
5.09
3.07
1.0
1.1
1.93
1.84
mmol/l
—
8
16
12
36
3.42
3.05
1.2
1.2
—
—
—
0
0
9
21
4.37
3.01
6.0
4.3
—
—
—
0
0
14
53
2.71
2.83
1.3
1.2
—
—
—
0
0
23
111
2.15
2.80
3.8
9.0
1.60
1.62
%
0.04
23
105
284
2568
1.59
2.79
5.8
4.7
6.18
6.01
mmol/l
1.01
255
2319
15
60
2.57
2.74
1.7
1.5
—
—
—
0
0
37
214
1.82
2.73
2.5
2.4
45.41
62.61
ml/min/173m2
2.16
23
95
6
10
6.08
2.71
4.2
2.0
92.33
94.00
%
—
6
10
11
35
3.21
2.67
1.8
1.5
86.80
106.86
u/ml
—
5
7
8
20
4.07
2.58
1.0
1.2
—
—
—
0
0
5
7
7.23
2.55
1.0
1.1
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
11
5.53
2.55
1.0
1.3
—
—
—
0
0
6
11
5.53
2.55
1.7
1.4
—
—
—
0
0
7
16
4.44
2.48
2.9
1.9
5023.43
1177.44
u/ml
—
7
16
7
16
4.44
2.48
1.0
1.0
—
—
—
0
0
44
277
1.67
2.44
3.8
2.5
7.08
9.12
ug/l
0.42
37
244
6
12
5.07
2.41
7.8
4.9
199.33
219.17
u/l
—
6
12
6
12
5.07
2.41
3.5
2.4
—
—
—
0
0
6
12
5.07
2.41
1.2
1.0
—
—
—
0
0
6
12
5.07
2.41
3.3
2.4
—
—
—
0
0
9
27
3.39
2.41
1.9
3.0
—
—
—
0
0
58
396
1.56
2.32
1.3
1.3
10.60
7.00
u/ml
0.18
25
148
274
2489
1.48
2.32
32.9
14.3
72.34
77.74
ml/min/173m2
2.87
243
2059
21
106
2.04
2.31
2.1
2.2
282.19
344.78
ug/l
0.26
21
101
65
458
1.52
2.26
3.8
2.9
4.73
1.95
e6/l
0.68
39
257
7
19
3.74
2.16
1.0
1.7
18.57
14.47
u/l
—
7
19
7
19
3.74
2.16
1.3
1.3
—
—
—
0
0
6
14
4.34
2.16
25.0
12.1
1209.50
1889.71
nmol/l
—
6
14
6
14
4.34
2.16
1.0
1.1
—
—
—
0
0
41
263
1.63
2.13
2.2
2.4
29.83
33.42
u/l
0.43
35
215
8
28
2.90
1.87
1.5
1.3
—
—
—
0
0
11
46
2.44
1.87
1.1
1.3
—
42.07
—
0
7
6
17
3.57
1.84
1.5
1.5
132.17
78.12
umol/l
—
6
17
7
23
3.08
1.81
1.0
1.0
—
—
—
0
0
10
41
2.48
1.65
3.6
2.4
103.80
106.24
mmol/l
—
10
41
5
14
3.61
1.62
1.8
1.4
—
—
—
0
0
5
14
3.61
1.62
16.8
9.6
623.40
993.93
nmol/l
—
5
14
5
14
3.61
1.62
1.8
1.4
—
—
—
0
0
12
57
2.14
1.57
1.3
1.3
—
—
—
0
0
12
57
2.14
1.57
1.3
1.3
—
—
—
0
0
296
2790
1.42
1.50
19.5
10.4
25.26
25.84
u/l
0.23
291
2684
276
2574
1.36
1.48
4.7
4.6
4.33
4.52
mmol/l
1.80
250
2360
48
348
1.44
1.47
19.4
7.6
—
—
—
0
0
5
16
3.15
1.44
1.8
1.8
—
—
—
0
0
9
179
0.49
1.44
2.3
1.7
—
—
—
0
0
274
2557
1.34
1.43
4.7
4.6
1.32
1.43
mmol/l
3.37
247
2316
22
134
1.69
1.43
1.1
1.2
27.57
102.64
iu/ml
—
7
51
9
41
2.23
1.38
1.1
1.0
—
—
—
0
0
305
2902
1.43
1.35
53.2
22.2
36.01
40.27
%
20.64
291
2704
281
2641
1.34
1.33
5.1
5.1
2.48
2.66
mmol/l
2.15
255
2400
5
18
2.80
1.29
1.4
1.1
—
—
—
0
0
265
2475
1.30
1.28
4.4
4.1
1.50
1.27
mmol/l
4.24
240
2235
8
37
2.19
1.22
1.5
1.2
—
—
—
0
0
14
79
1.80
1.18
1.1
1.2
—
—
—
0
0
14
80
1.78
1.14
1.1
1.2
—
—
—
0
0
11
58
1.93
1.13
1.5
1.2
—
—
—
0
0
7
30
2.36
1.13
1.1
1.1
—
—
—
0
0
7
31
2.28
1.11
1.1
1.1
—
—
—
0
0
135
1185
1.23
1.07
4.7
5.0
2.22
3.39
ug/l
0.99
119
1049
5
22
2.29
1.03
1.2
1.6
111.00
383.47
u/l
—
5
22
11
61
1.83
0.99
1.9
1.4
—
—
—
0
0
23
157
1.50
0.99
2.0
2.5
—
10.50
—
0
8
5
23
2.19
0.98
1.0
1.2
—
—
—
0
0
5
23
2.19
0.98
1.0
1.2
—
—
—
0
0
5
23
2.19
0.98
1.0
1.2
—
—
—
0
0
5
23
2.19
0.98
1.0
1.2
—
—
—
0
0
5
23
2.19
0.98
1.0
1.2
—
—
—
0
0
82
690
1.25
0.95
1.5
1.7
1.53
1.38
mmol/l
0.66
58
571
6
30
2.02
0.87
1.3
1.3
—
—
—
0
0
19
134
1.44
0.73
2.0
3.5
25.00
2208.25
u/ml
1.00
14
115
5
25
2.01
0.73
1.0
1.4
—
—
—
0
0
5
27
1.86
0.68
3.8
1.7
—
—
—
0
0
21
156
1.37
0.62
2.0
1.8
—
—
—
0
0
29
365
0.78
0.62
1.4
1.4
—
—
—
0
0
17
123
1.40
0.59
1.1
1.3
—
—
—
0
0
8
53
1.52
0.59
1.3
1.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.1
—
—
—
0
0
5
89
0.56
0.56
2.0
1.6
7.34
3.31
mg/l
—
5
68
22
280
0.77
0.52
1.9
1.5
—
—
—
0
0
7
51
1.38
0.44
1.4
1.3
—
—
—
0
0
8
56
1.44
0.43
1.4
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.5
—
—
—
0
0
5
34
1.48
0.40
2.4
3.9
—
—
—
0
0
0
18
0.00
0.40
0.0
1.2
—
157.08
—
0
18
21
171
1.24
0.36
2.2
1.9
—
—
—
0
0
62
562
1.13
0.33
5.5
3.8
89.22
228.85
ng/l
1.21
55
459
39
346
1.14
0.29
4.4
4.7
31.97
31.82
%
0.02
29
229
7
57
1.23
0.29
1.1
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
3.3
—
92.23
—
0
13
7
61
1.15
0.17
1.0
1.1
—
1.19
—
0
7
5
66
0.75
0.17
1.2
1.4
36.88
27.37
iu/l
—
5
57
65
686
0.94
0.16
3.0
3.1
0.86
0.78
ug/l
0.39
46
463
21
232
0.90
0.13
2.2
2.1
11.88
13.24
nmol/l
0.22
16
211
99
961
1.04
0.10
4.1
4.4
19.74
21.70
%
0.84
51
467
13
117
1.12
0.08
1.1
1.1
—
—
—
0
0
6
73
0.82
0.07
1.8
1.7
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
0
6
0.00
0.00
0.0
1.0
—
131.67
—
0
6
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
9.44
—
0
9
6
59
1.02
-0.00
1.3
1.7
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
—
—
0
0
5
52
0.96
-0.00
1.6
1.7
—
—
—
0
0
(40770918) von Willebrand factor (vWf).activity actual/normal in Platelet poor plasma by Immunoassay
0
7
0.00
-0.00
0.0
2.6
—
125.57
—
0
7
Mortality – FinRegistry
↥Association
Association between endpoint D3_ANAEMIA_FOLATEDEF and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_FOLATEDEF | 2.382 [1.91, 2.97] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.288 |
During the follow-up period (1.1.1998 — 31.12.2019), 554 out of 967 females with D3_ANAEMIA_FOLATEDEF died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_ANAEMIA_FOLATEDEF | 2.386 [1.81, 3.15] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 830 males with D3_ANAEMIA_FOLATEDEF died.
Mortality risk
Mortality risk for people of age
years, who have D3_ANAEMIA_FOLATEDEF.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.183% | 0.443% |
| 5 | 1.258% | 2.584% |
| 10 | 3.126% | 6.782% |
| 15 | 6.507% | 13.05% |
| 20 | 11.211% | 21.332% |
Relationships between endpoints
↥Index endpoint: D3_ANAEMIA_FOLATEDEF – Folate deficiency anaemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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