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Folate deficiency anaemia

DOID Endpoint Browser PheWeb

D3_ANAEMIA_FOLATEDEF

Endpoint definition

↥

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — D52
  • Hospital discharge: ICD-9 — 2812
  • Hospital discharge: ICD-8 — 2812
  • Cause of death: ICD-10 — D52
  • Cause of death: ICD-9 — 2812
  • Cause of death: ICD-8 — 2812

2 out of 7 registries used, show all original rules.

291

4. Check minimum number of events

None

291

5. Include endpoints

None

291

6. Filter based on genotype QC (FinnGen only)

291

Control definitions (FinnGen only)

Control exclude
D3_NUTRIANAEMIA

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
D50-D53
Name in latin
Anaemia ex deficientia folatorum

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 2872 1482 1356
Only index persons 2205 1156 1049
Unadjusted period prevalence (%)
Whole population 0.04 0.04 0.04
Only index persons 0.04 0.04 0.04
Median age at first event (years)
Whole population 72.84 75.31 70.14
Only index persons 72.08 74.17 69.79

-FinnGen-

Key figures

All Female Male
Number of individuals 291 121 170
Unadjusted period prevalence (%) 0.06 0.04 0.07
Median age at first event (years) 65.92 60.45 69.82

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
250
Matched controls
2500
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D52.9
ICD-10 Finland
Folate deficiency anaemia, unspecified
4077.6
185.9
156
*
D52.0
ICD-10 Finland
Dietary folate deficiency anaemia
+∞
64.4
59
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
28.7
36.1
49
21
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
5.2
31.6
132
440
D51.9
ICD-10 Finland
Vitamin B12deficiency anaemia, unspecified
126.1
31.5
33
*
D64.9
ICD-10 Finland
Anaemia, unspecified
7.8
30.9
79
140
D52.8
ICD-10 Finland
Other folate deficiency anaemias
+∞
23.3
22
*
B03BA03
ATC
hydroxocobalamin; parenteral
11.0
23.0
45
49
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
51.1
16.3
19
*
107
Kela drug reimbursment
Pernicious anaemia
+∞
13.7
13
*
XW000
NOMESCO Finland
Bone marrow biopsy
9.1
13.5
28
34
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.9
12.4
35
67
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.3
12.2
70
263
B81
ICPC
Anaemia vit B12/folate deficiency
10.4
12.0
23
24
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
3.9
12.0
53
162
E87.6
ICD-10 Finland
Hypokalaemia
8.2
11.0
24
32
AA1AD
NOMESCO Finland
CT of head and brain
2.8
10.6
82
372
D53.1
ICD-10 Finland
Other megaloblastic anaemias, not elsewhere classified
+∞
10.5
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.4
10.0
128
761
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
5.9
9.8
27
50
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
9.8
61
240
N17.9
ICD-10 Finland
Acute renal failure, unspecified
6.7
9.7
24
39
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.5
9.5
96
500
A02BC02
ATC
pantoprazole; systemic
2.4
9.5
171
1187
D52.1
ICD-10 Finland
Drug-induced folate deficiency anaemia
+∞
9.4
9
*
C03CA01
ATC
furosemide; systemic
2.4
9.2
101
550
R53
ICD-10 Finland
Malaise and fatigue
2.7
8.8
68
305
UJF30
NOMESCO Finland
Ileoscopy through colon
4.2
8.8
33
87
H02AB06
ATC
prednisolone; systemic
2.2
8.6
128
798
WW500
NOMESCO Finland
Blood transfusion
6.6
8.5
21
34
28120
ICD-8 Finland
Other vitamin B12 deficiency anaemia, Folic acid deficiency anaemia
+∞
8.4
8
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.1
8.1
45
163
JN3AD
NOMESCO Finland
Abdominal CT examination
3.7
7.6
33
99
D50.8
ICD-10 Finland
Other iron deficiency anaemias
82.4
7.5
8
*
E55.9
ICD-10 Finland
Vitamin D deficiency, unspecified
82.4
7.5
8
*
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.2
7.3
91
513
A04
ICPC
Weakness/tiredness general
3.0
6.9
42
160
K70.3
ICD-10 Finland
Alcoholic cirrhosis of liver
11.4
6.9
12
11
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.2
6.8
80
437
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
6.8
51
221
L28
ICPC
Limited function/disability (L)
2.5
6.7
54
245
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
6.6
53
239
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.8
6.6
27
78
N06AX11
ATC
mirtazapine; oral
2.1
6.5
85
486
A41.9
ICD-10 Finland
Sepsis, unspecified
5.1
6.4
19
40
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
2.2
6.3
77
426
E86
ICD-10 Finland
Volume depletion
5.3
6.3
18
36
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
7.3
6.3
14
20
C07AB07
ATC
bisoprolol; oral
2.0
6.3
127
859
JN4AD
NOMESCO Finland
Body CT examination
3.5
6.3
28
87
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.6
6.2
46
199
A46
ICD-10 Finland
Erysipelas
2.6
6.2
45
192
N05AH04
ATC
quetiapine; oral
2.6
6.0
44
188

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
140
293
8.28
71.72
2.9
2.3
25.3
24.0
%
0.31
128
251
142
322
7.66
66.67
2.9
2.2
1.9
2.2
g/l
6.22
134
298
83
105
10.66
64.86
1.9
2.0
1.6
1.5
g/l
0.16
66
92
146
352
7.32
64.10
3.1
2.2
12.1
13.4
umol/l
0.95
137
324
106
184
8.49
63.72
5.2
3.0
72.0
66.8
e9/l
0.47
85
146
124
261
7.54
62.08
4.9
2.9
2.1
1.7
%
2.40
111
240
180
561
6.79
59.33
2.5
1.6
18.3
20.7
nmol/l
0.66
158
468
171
540
6.25
54.54
3.5
1.9
3.0
2.9
mg/l
0.33
156
466
87
187
6.21
41.01
2.5
2.9
64.3
66.5
g/l
1.33
82
167
81
163
6.50
40.88
2.3
2.4
—
—
—
0
0
44
52
9.79
35.32
3.5
2.0
33.8
34.1
umol/l
0.02
37
42
43
50
9.92
34.92
1.7
5.6
—
—
—
0
0
191
888
4.35
32.55
4.5
2.4
304.1
135.8
ug/l
4.91
179
815
49
76
7.55
31.34
2.1
4.4
84.5
151.2
mg/l
0.34
34
60
49
76
7.55
31.34
2.1
4.4
47.1
41.2
mg/l
0.33
33
61
80
204
5.03
30.42
2.6
2.3
0.2
0.2
g/l
1.60
71
188
69
159
5.38
29.48
2.9
2.4
11.1
10.8
g/l
0.15
63
139
157
678
3.86
28.80
6.6
4.4
—
—
—
0
0
185
927
3.73
26.32
3.0
2.0
80.1
94.8
pmol/l
5.43
135
488
186
985
3.46
23.21
7.4
4.6
31.4
35.3
g/l
12.95
176
919
151
709
3.35
22.95
7.7
5.4
—
—
—
0
0
25
25
10.85
22.35
2.8
2.4
32.4
33.4
pg
0.37
25
25
192
1054
3.42
22.23
8.7
5.6
0.6
0.6
e9/l
1.27
170
918
192
1061
3.38
21.84
8.7
5.6
0.0
0.0
e9/l
0.38
171
930
194
1082
3.38
21.66
8.9
5.6
1.7
2.0
e9/l
1.50
176
961
195
1100
3.34
21.17
8.9
5.8
0.2
0.2
e9/l
0.06
173
972
193
1109
3.20
19.77
11.7
6.8
1.2
1.2
mmol/l
1.73
154
941
182
1019
3.10
19.38
9.6
5.9
23.8
26.9
%
2.66
172
942
111
473
3.18
19.20
2.9
1.7
1330.9
1171.8
nmol/l
0.86
89
365
97
382
3.31
19.15
1.9
1.4
3.4
2.5
g/l
1.87
71
228
201
1199
3.19
18.95
11.2
6.3
14.0
11.6
umol/l
0.60
192
1123
175
969
3.02
18.82
9.4
5.7
0.6
0.7
%
0.95
165
902
114
499
3.11
18.75
2.2
1.7
423.4
431.0
pmol/l
0.09
93
416
179
1005
3.03
18.74
9.7
6.0
8.9
8.7
%
0.28
168
938
20
19
11.23
18.42
1.1
1.3
—
—
—
0
0
177
996
2.98
18.31
9.4
5.7
2.5
2.7
%
0.72
166
922
176
1012
2.87
17.06
8.7
5.6
61.5
58.0
%
2.97
167
944
59
181
3.83
16.96
5.5
4.8
1.1
1.0
%
0.11
35
63
56
166
3.94
16.90
5.6
5.0
0.1
0.1
%
0.64
33
56
28
46
6.63
16.72
4.6
3.6
—
—
—
0
0
177
1035
2.81
16.37
10.6
6.3
1.2
1.2
mmol/l
2.28
167
926
28
48
6.35
16.04
3.1
2.4
—
—
—
0
0
132
673
2.76
15.85
4.8
3.3
—
—
—
0
0
74
276
3.25
15.66
1.3
1.3
—
—
—
0
0
52
157
3.82
15.22
4.9
4.9
0.6
0.3
%
0.84
24
43
131
677
2.70
15.17
6.5
4.1
7.4
7.4
ph
0.37
40
115
27
48
6.10
14.90
5.0
2.7
13.5
15.9
%
1.86
19
23
196
1247
2.75
14.72
14.9
9.1
4.8
4.2
e9/l
2.44
181
1098
19
23
8.77
14.67
1.4
3.8
—
—
—
0
0
51
156
3.75
14.62
4.7
2.9
7.4
7.4
ph
0.44
19
19
51
158
3.70
14.34
4.7
2.9
5.1
5.1
kpa
0.11
51
147
97
442
2.79
14.22
8.5
5.4
—
—
—
0
0
164
968
2.59
14.18
13.9
8.7
1.2
1.2
inr
0.00
57
268
26
48
5.85
13.80
1.5
2.0
—
—
—
0
0
20
28
7.60
13.72
4.2
4.0
56.0
60.9
%
0.70
20
28
28
56
5.43
13.66
1.2
1.3
—
—
—
0
0
91
409
2.78
13.62
1.3
1.2
2.1
1.5
u/ml
0.23
28
106
66
249
3.13
13.56
1.5
1.3
354.7
492.1
titre
0.34
15
66
60
215
3.26
13.43
6.3
3.4
1.1
1.4
mmol/l
0.25
51
165
50
161
3.54
13.24
6.0
4.9
0.0
0.2
%
0.57
27
49
19
27
7.46
12.86
3.5
3.4
4.1
4.8
e9/l
0.39
19
27
50
166
3.43
12.60
8.7
3.9
1.2
1.2
mmol/l
1.55
45
148
57
207
3.18
12.42
1.6
1.6
—
—
—
0
0
54
192
3.23
12.18
8.9
8.5
—
—
—
0
0
28
62
4.89
12.17
3.6
2.1
8.0
8.0
kpa
0.00
28
54
41
122
3.75
12.16
8.3
6.7
23.4
24.2
mmol/l
0.53
41
122
22
39
6.02
12.14
4.5
4.1
1.3
2.4
%
0.41
16
32
133
757
2.39
11.84
4.2
3.2
2739.4
1438.8
ng/l
1.84
113
656
127
711
2.40
11.71
3.1
2.1
667.1
271.7
u/l
0.37
121
663
25
52
5.17
11.66
7.6
3.5
8.3
8.2
kpa
0.09
25
52
127
713
2.39
11.61
4.3
2.4
54.8
57.2
u/l
0.25
118
658
13
13
10.42
11.42
1.9
1.8
—
—
—
0
0
46
154
3.36
11.41
2.8
3.7
97.7
82.7
ng/l
0.39
36
139
19
31
6.49
11.34
1.2
1.2
—
—
—
0
0
21
38
5.88
11.34
4.1
1.9
2.2
1.5
mmol/l
2.14
21
38
15
19
8.27
11.11
1.1
1.2
—
—
—
0
0
67
283
2.78
11.08
1.7
1.7
—
—
—
0
0
211
1498
2.49
10.97
7.2
4.6
702.2
1011.8
e6/l
—
6
29
24
52
4.94
10.68
7.6
3.5
4.8
5.0
kpa
0.67
24
52
58
231
2.89
10.68
1.5
1.5
—
—
—
0
0
27
67
4.34
10.21
1.3
1.6
195.1
259.0
ug/g
0.77
15
35
195
1364
2.30
10.07
11.1
5.0
6.9
6.7
mmol/l
0.46
189
1285
149
937
2.21
9.99
22.8
9.8
0.0
0.0
e9/l
0.29
128
775
14
19
7.69
9.78
3.7
1.8
1.0
0.7
e9/l
—
9
6
22
48
4.88
9.70
1.0
1.1
—
—
titre
—
0
0
127
761
2.19
9.49
3.2
3.4
2.3
2.3
mmol/l
1.57
111
660
155
1007
2.15
9.38
6.7
4.1
—
—
—
0
0
119
700
2.18
9.27
4.2
2.4
—
—
—
0
0
59
256
2.64
9.15
2.5
1.6
—
—
—
0
0
146
938
2.12
8.97
7.5
4.0
41.2
43.6
ng/l
0.11
130
698
110
635
2.18
8.91
4.4
2.8
380.8
9044.5
umol/l
3.46
99
534
68
322
2.45
8.77
2.1
1.9
—
—
—
0
0
19
40
5.01
8.72
1.7
1.1
—
—
—
0
0
119
720
2.10
8.45
5.1
3.3
32.9
138.7
e6/l
0.62
98
555
23
59
4.15
8.32
3.1
2.4
2.0
1.5
mg/l
1.67
23
53
16
30
5.59
8.30
5.9
4.6
—
—
—
0
0
58
262
2.52
8.24
5.4
3.0
16.3
9.4
umol/l
0.48
48
230
87
475
2.19
7.98
4.7
2.9
475.5
563.7
mosm/kgh2o
4.68
80
397
19
44
4.55
7.80
1.3
1.2
—
—
—
0
0
45
184
2.71
7.79
9.0
4.0
—
—
—
0
0
114
700
2.03
7.61
5.4
3.9
—
—
—
0
0
49
212
2.58
7.58
2.1
2.2
193.7
166.2
ug/g
0.25
43
170
14
26
5.61
7.32
3.2
3.1
60.3
53.5
%
—
8
18
15
30
5.22
7.26
1.1
1.2
—
—
—
0
0
16
34
4.92
7.25
4.8
1.7
89.0
90.7
%
0.53
16
34
105
637
2.01
7.17
4.9
3.2
—
—
—
0
0
14
27
5.40
7.04
1.2
1.1
404.5
279.7
u/ml
—
8
15
211
1637
2.05
6.91
6.9
4.1
23.6
12.6
mm/h
9.14
197
1491
26
83
3.34
6.90
2.5
1.7
34.5
37.7
g/l
1.05
21
70
36
140
2.79
6.84
1.6
1.5
—
—
—
0
0
10
6
17.18
6.79
1.2
1.2
—
—
—
0
0
15
32
4.89
6.77
1.5
1.4
—
—
—
0
0
125
820
1.92
6.70
5.8
3.8
151.0
80.0
e6/l
0.52
101
602
31
115
2.90
6.42
2.9
2.4
—
—
—
0
0
104
656
1.91
6.18
4.9
3.3
0.5
0.4
e6/l
0.40
83
490
199
1545
1.91
6.09
6.7
4.3
—
—
—
0
0
54
272
2.21
5.91
1.7
1.4
—
—
—
0
0
206
1629
1.91
5.82
4.6
3.8
15.3
14.8
pmol/l
1.73
191
1443
152
1096
1.81
5.79
7.7
5.1
0.0
0.0
estimate
0.00
48
198
151
1096
1.79
5.55
6.5
3.8
0.0
0.0
estimate
0.00
47
198
152
1106
1.78
5.53
6.5
3.8
0.0
0.0
estimate
0.00
48
191
75
438
1.96
5.52
3.3
3.1
2.5
2.5
mmol/l
0.46
70
383
28
107
2.79
5.50
1.6
1.3
—
—
—
0
0
8
5
16.38
5.44
1.3
1.0
—
—
—
0
0
15
39
4.00
5.33
3.9
2.6
—
—
—
0
0
31
128
2.59
5.25
3.3
2.2
1.4
1.2
%
0.56
31
128
5
0
+∞
5.22
1.0
0.0
—
—
mmol/l
—
0
0
5
0
+∞
5.22
1.0
0.0
—
—
mmol/l
—
0
0
94
605
1.82
5.08
8.2
4.2
0.0
0.0
estimate
0.00
47
190
10
19
5.41
5.07
1.0
1.1
—
—
—
0
0
78
478
1.86
4.91
2.1
1.6
1.3
1.4
mg/l
0.03
64
377
27
109
2.63
4.79
5.8
3.0
—
—
—
0
0
12
29
4.27
4.67
1.0
1.1
—
—
—
0
0
11
25
4.53
4.60
2.3
2.1
—
—
—
0
0
50
272
2.01
4.45
10.7
9.0
0.9
1.2
mmol/l
0.12
38
213
25
102
2.59
4.35
12.7
3.8
—
—
—
0
0
14
41
3.54
4.24
1.1
1.2
—
—
—
0
0
8
10
8.19
4.08
1.3
2.4
—
—
—
0
0
44
237
2.01
4.02
1.4
1.3
—
—
—
0
0
12
33
3.75
3.96
1.8
1.2
—
—
—
0
0
10
24
4.28
3.92
2.3
1.4
—
—
—
0
0
82
551
1.68
3.66
8.8
6.6
—
—
—
0
0
36
187
2.06
3.63
1.5
1.4
—
—
—
0
0
232
2018
1.74
3.54
5.6
4.5
2.0
1.9
mu/l
0.04
221
1815
18
69
2.71
3.54
3.4
3.5
0.2
0.2
g/l
0.30
11
24
11
31
3.65
3.51
1.2
1.2
—
—
—
0
0
6
6
10.17
3.51
1.7
1.5
24.5
32.7
umol/l
—
6
6
32
162
2.10
3.45
8.1
7.2
—
—
—
0
0
13
43
3.12
3.29
1.2
2.0
—
—
—
0
0
11
33
3.42
3.22
1.7
1.4
—
—
—
0
0
7
11
6.49
3.20
1.0
1.1
110.4
142.1
nmol/l
—
7
11
28
141
2.09
3.07
2.3
2.6
5.2
3.9
e9/l
1.06
21
110
113
854
1.53
3.00
2.2
2.2
—
—
—
0
0
40
232
1.84
2.95
12.5
10.1
107.2
122.4
g/l
3.51
40
223
85
606
1.57
2.92
6.7
3.5
—
—
—
0
0
9
22
4.19
2.90
1.7
1.8
—
—
—
0
0
9
22
4.19
2.90
1.7
1.8
—
—
—
0
0
9
22
4.19
2.90
1.7
1.8
—
—
—
0
0
9
22
4.19
2.90
1.7
1.8
—
—
—
0
0
8
18
4.54
2.81
2.1
1.5
—
—
—
0
0
38
222
1.82
2.74
9.5
3.9
—
—
—
0
0
34
192
1.87
2.73
5.6
3.5
—
—
—
0
0
11
37
3.05
2.72
1.0
1.1
—
—
—
0
0
6
10
6.10
2.71
1.2
1.2
—
—
—
0
0
6
10
6.10
2.71
1.0
1.0
—
—
—
0
0
12
43
2.87
2.68
1.8
1.3
—
—
—
0
0
12
43
2.87
2.68
1.8
1.4
—
—
—
0
0
93
690
1.51
2.64
3.4
3.3
1892.1
213.7
mg/l
0.95
56
452
19
87
2.27
2.63
2.3
2.3
275.4
370.2
ug/l
0.37
19
82
7
15
4.75
2.61
1.0
1.1
1.9
1.8
mmol/l
—
7
15
8
20
4.08
2.58
1.4
1.2
—
—
—
0
0
12
44
2.80
2.58
1.8
1.4
—
—
—
0
0
12
44
2.80
2.58
1.1
1.4
—
—
—
0
0
12
44
2.80
2.58
1.8
1.4
—
—
—
0
0
53
347
1.64
2.57
23.8
26.1
1.2
1.3
inr
—
7
45
96
725
1.48
2.48
4.5
4.1
14.9
9.8
mg/mmol
0.37
52
460
8
21
3.89
2.48
2.8
2.4
—
—
—
0
0
38
232
1.73
2.38
3.9
2.5
6.5
9.6
ug/l
0.71
32
205
93
703
1.47
2.38
3.4
3.2
6.4
7.5
mmol/l
1.65
70
587
8
22
3.71
2.38
1.5
1.2
—
—
—
0
0
5
8
6.33
2.38
1.2
1.0
—
—
—
0
0
5
8
6.33
2.38
1.0
1.1
—
—
—
0
0
53
354
1.61
2.37
1.4
1.3
24.8
31.8
iu/ml
0.23
15
118
7
17
4.19
2.37
1.0
1.2
—
—
—
0
0
9
28
3.28
2.32
1.7
1.1
—
—
—
0
0
9
28
3.28
2.32
3.0
2.7
—
—
—
0
0
71
511
1.52
2.30
5.6
3.7
—
—
—
0
0
7
20
3.56
2.07
1.4
1.2
—
—
—
0
0
241
2205
1.54
2.06
38.3
15.2
25.4
24.9
mg/l
0.12
230
1761
8
26
3.13
2.03
1.0
1.3
—
—
—
0
0
17
84
2.09
2.00
1.6
1.6
—
—
—
0
0
5
11
4.60
1.95
2.2
2.7
1584.0
2272.3
ml
—
5
11
49
337
1.55
1.94
1.3
1.3
10.5
7.7
u/ml
0.11
20
130
6
16
3.81
1.94
1.3
1.1
—
—
—
0
0
11
46
2.45
1.87
1.8
3.1
1.3
1.0
nmol/l
—
6
34
5
12
4.22
1.83
2.8
2.0
6848.4
1047.1
u/ml
—
5
12
6
18
3.38
1.75
2.3
2.1
—
—
—
0
0
6
18
3.38
1.75
1.5
1.3
—
—
—
0
0
5
14
3.61
1.62
1.2
1.1
—
—
—
0
0
232
2144
1.40
1.53
5.7
4.8
6.1
6.0
mmol/l
0.49
205
1940
6
21
2.89
1.51
1.2
1.4
—
—
—
0
0
17
94
1.86
1.50
1.2
1.2
—
—
—
0
0
11
52
2.16
1.46
3.4
2.8
2.1
1.5
mmol/l
1.08
11
52
16
88
1.87
1.44
3.9
10.2
1.6
1.7
%
0.11
16
82
6
22
2.76
1.44
1.3
1.1
—
—
—
0
0
225
2078
1.36
1.42
7.1
6.0
39.1
40.4
mmol/mol
1.30
207
1931
68
533
1.36
1.37
1.6
1.4
—
—
—
0
0
16
90
1.82
1.36
3.9
10.1
0.9
0.9
%
0.03
16
84
18
107
1.73
1.29
1.5
1.6
—
—
—
0
0
5
20
2.53
1.15
1.2
1.1
—
—
—
0
0
5
20
2.53
1.15
3.0
2.8
—
—
—
0
0
22
143
1.58
1.15
1.1
1.2
—
—
—
0
0
37
271
1.42
1.12
1.4
1.2
—
—
—
0
0
10
53
1.92
1.02
2.2
3.0
—
—
—
0
0
12
68
1.80
1.02
1.1
1.2
—
—
—
0
0
46
581
0.75
0.98
3.0
3.1
0.9
0.8
ug/l
0.38
32
395
6
28
2.17
0.92
1.7
1.1
—
—
—
0
0
6
28
2.17
0.92
1.7
1.1
—
—
—
0
0
6
29
2.09
0.90
1.7
1.7
—
—
—
0
0
8
42
1.93
0.89
1.9
1.7
50.6
64.7
%
—
8
42
228
2156
1.27
0.89
4.4
4.7
4.3
4.5
mmol/l
1.94
204
1981
18
120
1.53
0.87
14.9
14.1
—
—
—
0
0
8
141
0.56
0.85
1.1
1.3
—
—
—
0
0
6
31
1.95
0.85
2.3
3.3
—
—
—
0
0
226
2141
1.25
0.83
4.5
4.6
1.3
1.4
mmol/l
2.30
201
1941
219
2075
1.22
0.76
4.2
4.2
1.4
1.3
mmol/l
2.38
196
1877
5
24
2.10
0.75
1.4
1.2
—
—
—
0
0
5
24
2.10
0.75
2.4
1.0
—
—
—
0
0
14
92
1.55
0.73
2.3
1.9
—
—
—
0
0
238
2280
1.24
0.70
36.8
14.2
—
—
—
0
0
206
1948
1.20
0.69
29.2
16.2
34.7
40.1
%
7.11
110
1348
59
501
1.22
0.66
6.8
4.2
1.0
1.0
kg/l
—
6
64
11
71
1.57
0.63
3.1
3.5
—
—
—
0
0
19
139
1.39
0.62
2.1
2.5
—
9.0
—
0
6
0
20
0.00
0.60
0.0
1.4
—
0.2
—
0
15
17
123
1.41
0.59
4.3
3.7
—
—
—
0
0
6
35
1.73
0.58
2.0
2.5
—
—
—
0
0
6
36
1.68
0.57
2.0
2.5
3.9
4.1
mmol/l
—
6
36
6
36
1.68
0.57
2.0
2.5
102.3
106.4
mmol/l
—
6
36
10
67
1.51
0.50
4.9
4.6
—
—
—
0
0
229
2211
1.17
0.48
4.8
5.2
2.5
2.7
mmol/l
2.35
205
2009
5
81
0.61
0.46
1.8
1.9
—
—
—
0
0
107
989
1.13
0.43
4.3
5.1
2.3
2.7
ug/l
0.49
93
875
166
1576
1.12
0.42
6.3
4.2
—
—
—
0
0
8
59
1.37
0.41
1.3
1.2
—
—
—
0
0
0
17
0.00
0.41
0.0
1.1
—
89.7
—
0
5
15
115
1.32
0.39
1.1
1.2
34.8
94.0
iu/ml
—
5
42
7
54
1.30
0.30
2.9
2.0
—
—
—
0
0
64
595
1.10
0.23
1.4
1.7
1.4
1.3
mmol/l
0.37
44
492
77
723
1.09
0.23
3.3
3.1
—
—
—
0
0
51
471
1.10
0.21
5.5
3.8
97.2
241.4
ng/l
1.00
46
381
0
12
0.00
0.21
0.0
1.3
—
—
—
0
0
18
156
1.16
0.19
3.1
2.5
—
—
—
0
0
10
81
1.24
0.19
16.7
10.1
—
—
—
0
0
15
130
1.16
0.16
1.1
1.2
—
—
—
0
0
19
171
1.12
0.13
1.6
1.4
—
—
—
0
0
5
60
0.83
0.08
1.0
1.1
—
—
—
0
0
18
194
0.92
0.07
1.7
1.5
—
—
—
0
0
12
112
1.07
0.03
2.5
2.7
—
—
—
0
0
0
8
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
13.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
13.2
—
—
—
0
0
5
55
0.91
0.00
6.6
15.1
13.0
11.4
mmol/l
—
5
50
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
2.2
—
—
—
0
0
22
220
1.00
0.00
1.1
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.8
—
18.4
—
0
6
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
5
56
0.89
0.00
1.2
1.4
36.9
28.2
iu/l
—
5
49
5
55
0.91
0.00
6.6
15.1
102.6
105.9
mmol/l
—
5
50
0
6
0.00
0.00
0.0
1.0
—
1.7
—
0
6
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
13.2
—
—
—
0
0
0
5
0.00
0.00
0.0
3.2
—
1.1
—
0
5

Mortality – FinRegistry

↥

Association

Association between endpoint D3_ANAEMIA_FOLATEDEF and mortality.

Females

Parameter HR [95% CI] p-value
D3_ANAEMIA_FOLATEDEF 2.382 [1.91, 2.97] < 0.001
Birth year 0.995 [0.99, 1.0] 0.288

During the follow-up period (1.1.1998 — 31.12.2019), 554 out of 967 females with D3_ANAEMIA_FOLATEDEF died.

Males

Parameter HR [95% CI] p-value
D3_ANAEMIA_FOLATEDEF 2.386 [1.81, 3.15] < 0.001
Birth year 0.987 [0.98, 1.0] 0.006

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 830 males with D3_ANAEMIA_FOLATEDEF died.

Mortality risk

Mortality risk for people of age

years, who have D3_ANAEMIA_FOLATEDEF.

N-year risk Females Males
1 0.183% 0.443%
5 1.258% 2.584%
10 3.126% 6.782%
15 6.507% 13.05%
20 11.211% 21.332%

Relationships between endpoints

↥

Index endpoint: D3_ANAEMIA_FOLATEDEF – Folate deficiency anaemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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