No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
496 |
4. Check minimum number of eventsNone |
496 |
5. Include endpointsNone |
496 |
6. Filter based on genotype QC (FinnGen only) |
477 |
Control definitions (FinnGen only)
- Control exclude
- D3_COAGDEF_PURPUR_HAEMORRHAGIC
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- D68
- Name in latin
- Morbus von Willebrand
Similar endpoints
↥List of similar endpoints to
Von Willebrand disease
based on the number of shared cases.
Similar with more cases:
- Other coagulation defects
- Coagulation defects, purpura and other haemorrhagic conditions
- Diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism
- Any operation in hilmo
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3361 | 2297 | 1052 |
| Only index persons | 3158 | 2208 | 950 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.07 | 0.03 |
| Only index persons | 0.07 | 0.08 | 0.04 |
| Median age at first event (years) | |||
| Whole population | 28.87 | 33.42 | 18.84 |
| Only index persons | 28.84 | 33.23 | 18.62 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 477 | 402 | 75 |
| Unadjusted period prevalence (%) | 0.13 | 0.14 | 0.03 |
| Median age at first event (years) | 37.81 | 37.72 | 38.26 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 496
- Matched controls
- 4960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
D68.0
ICD-10 Finland
Von Willebrand disease
+∞
307.7
482
*
B02AA02
ATC
tranexamic acid; systemic
22.8
272.5
375
593
126
Kela drug reimbursment
Chronic coagulation defects
+∞
147.4
134
*
O99.1
ICD-10 Finland
Other diseases of the blood and blood-forming organs and certain disorders involving the immune mechanism complicating pregnancy, childbirth and the puerperium
49.3
90.2
53
12
D68.9
ICD-10 Finland
Coagulation defect, unspecified
+∞
66.1
62
*
D68.8
ICD-10 Finland
Other specified coagulation defects
151.1
51.9
54
*
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
11.7
41.4
44
41
2864A
ICD-9 Finland
Coagulation defects, von Willebrand's disease
+∞
40.1
38
*
WZC10
NOMESCO Finland
Written specialist consultation based on a referral from a dentist or a physician
6.6
39.0
68
117
D69.9
ICD-10 Finland
Haemorrhagic condition, unspecified
133.0
35.2
37
*
28630
ICD-8 Finland
Coagulation defects, Vascular haemophilia
+∞
30.5
29
*
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
5.3
28.9
62
129
N02AX02
ATC
tramadol; systemic, rectal
2.8
27.4
253
1353
N92.0
ICD-10 Finland
Excessive and frequent menstruation with regular cycle
3.4
25.7
112
394
EBA10
NOMESCO Finland
Operative extraction of tooth
3.1
24.6
125
481
R04.0
ICD-10 Finland
Epistaxis
4.8
23.6
57
131
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
20.5
265
1597
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
19.6
239
1395
WZC00
NOMESCO Finland
Treatment plan or consultation
2.4
19.1
223
1274
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
19.0
343
4221
2BD06, ,
NOMESCO Finland
+∞
17.8
17
*
D68.2
ICD-10 Finland
Hereditary deficiency of other clotting factors
+∞
16.8
16
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.4
16.7
162
844
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
6.1
16.4
29
50
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.8
16.3
97
400
R79.8
ICD-10 Finland
Other specified abnormal findings of blood chemistry
21.8
16.1
23
11
ZX120
NOMESCO Finland
Intravenous
3.3
16.0
67
227
R42
ICD-10 Finland
Dizziness and giddiness
2.5
15.6
127
610
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
15.1
51
150
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
2.2
15.1
194
1129
UJF32
NOMESCO Finland
Coloscopy
2.3
14.2
134
684
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
3.4
13.9
54
174
ZXE00
NOMESCO Finland
One hour or less
2.0
13.4
227
1449
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
13.2
195
1183
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
2.0
13.1
241
1580
TLC00
NOMESCO Finland
Insertion of intrauterine device
2.9
13.1
67
254
N02AJ06
ATC
codeine and paracetamol; systemic
2.0
13.0
235
1531
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
12.8
129
674
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.1
12.7
167
967
194
Kela drug reimbursment
Blood coagulation factor VIII and von Willebrand factor for the treatment of von Willebrand disease
+∞
12.5
12
*
D66
ICD-10 Finland
Hereditary factor VIII deficiency
+∞
12.5
12
*
D69.6
ICD-10 Finland
Thrombocytopenia, unspecified
30.9
11.7
15
5
R01AD12
ATC
fluticasone furoate; nasal
2.0
11.6
206
1319
D69.1
ICD-10 Finland
Qualitative platelet defects
+∞
11.5
11
*
ZXD10
NOMESCO Finland
Scheduled procedure
2.0
11.4
200
1275
K08.3
ICD-10 Finland
Retained dental root
3.3
11.1
43
138
EBA15
NOMESCO Finland
Extraction of multiple teeth
5.0
11.1
24
50
R51.80
ICD-10 Finland
Headache
2.2
11.0
116
613
G43.9
ICD-10 Finland
Migraine, unspecified
2.7
11.0
61
241
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.5
10.9
73
317
K04.5
ICD-10 Finland
Chronic apical periodontitis
2.0
10.8
145
838
SAA03
NOMESCO Finland
Extended examination of mouth
1.9
10.8
241
1656
N02BE01
ATC
paracetamol; systemic, rectal
2.8
10.7
451
3867
H02AB06
ATC
prednisolone; systemic
1.9
10.5
240
1655
Z35.8
ICD-10 Finland
Supervision of other high-risk pregnancies
2.4
10.5
77
349
B02BD02
ATC
coagulation factor VIII; parenteral
+∞
10.4
10
*
K01.0
ICD-10 Finland
Embedded teeth
5.1
10.4
22
45
J01DB01
ATC
cefalexin; oral
2.4
10.1
430
3632
C01CA24
ATC
epinephrine; parenteral
2.7
9.9
54
211
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
9.9
109
584
N92.6
ICD-10 Finland
Irregular menstruation, unspecified
2.6
9.6
61
258
N03AX16
ATC
[U] pregabalin
2.0
9.5
124
707
B02BD06
ATC
von Willebrand factor and coagulation factor VIII in combination; parenteral, topical, urethral
+∞
9.4
9
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
9.3
85
423
3AC01, ,
NOMESCO Finland
14.0
9.2
15
11
J01DA01
ATC
[U] cefalexin
1.8
9.1
319
2465
Z31.5
ICD-10 Finland
Genetic counselling
2.7
9.0
49
191
J01FA10
ATC
azithromycin; systemic
1.8
9.0
336
2644
N92.1
ICD-10 Finland
Excessive and frequent menstruation with irregular cycle
2.6
8.8
55
230
P01AB01
ATC
metronidazole; oral, rectal
1.8
8.8
226
1590
AA1AD
NOMESCO Finland
CT of head and brain
2.0
8.8
112
631
J01FF01
ATC
clindamycin; systemic
1.9
8.8
138
835
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.3
8.8
73
349
D69.0
ICD-10 Finland
Allergic purpura
50.9
8.7
10
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
8.7
195
1319
R79.9
ICD-10 Finland
Abnormal finding of blood chemistry, unspecified
16.6
8.6
13
8
J45.9
ICD-10 Finland
Asthma, unspecified
2.0
8.6
107
598
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
3.7
8.5
27
76
D64.9
ICD-10 Finland
Anaemia, unspecified
2.7
8.4
46
180
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.8
8.4
160
1027
3A149, ,
NOMESCO Finland
+∞
8.4
8
*
2BDXX, ,
NOMESCO Finland
+∞
8.4
8
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.5
8.3
55
237
X59
ICD-10 Finland
Exposure to unspecified factor
2.0
8.3
101
559
R03AC02
ATC
salbutamol; inhalant
1.7
8.2
302
2336
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.1
8.2
34
114
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
8.2
54
232
R21
ICD-10 Finland
Rash and other nonspecific skin eruption
3.3
8.1
31
99
J01MA02
ATC
ciprofloxacin; systemic
1.8
8.0
173
1150
JN3AD
NOMESCO Finland
Abdominal CT examination
2.4
8.0
56
248
S06.0
ICD-10 Finland
Concussion
2.3
7.9
66
315
SHB00
NOMESCO Finland
Preparing and fitting the occlusal splint in the mouth
2.1
7.9
82
428
J01FA06
ATC
roxithromycin; oral
1.7
7.8
202
1412
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
7.8
131
807
N02CC01
ATC
sumatriptan; nasal, systemic, rectal
1.9
7.8
105
602
M25.5
ICD-10 Finland
Pain in joint
1.7
7.7
184
1255
UJF30
NOMESCO Finland
Ileoscopy through colon
2.4
7.7
57
258
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.7
7.7
288
2222
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
7.6
95
530
UJF45
NOMESCO Finland
Flexible sigmoidoscopy with biopsy
2.7
7.6
40
154
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
2.6
7.5
45
185
Z35.9
ICD-10 Finland
Supervision of high-risk pregnancy, unspecified
3.1
7.5
31
104
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
1.9
7.3
101
582
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.4
7.3
52
232
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
7.2
42
170
Z3231
NOMESCO Finland
Registered nurse
1.8
7.2
142
915
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.4
7.1
52
234
Z71.8
ICD-10 Finland
Other specified counselling
1.7
7.1
177
1216
M25.0
ICD-10 Finland
Haemarthrosis
10.2
7.1
13
13
SHA04
NOMESCO Finland
Stomatognathic treatment, very demanding
6.5
7.0
17
27
A06AD11
ATC
lactulose; oral
2.2
7.0
60
290
TLC02
NOMESCO Finland
Simple extraction of IUD
2.8
7.0
36
137
SPAT1229
SPAT
Assessment of need for aid
2.8
7.0
36
137
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.5
6.9
42
174
Z01.0
ICD-10 Finland
Examination of eyes and vision
1.9
6.8
93
533
9981A
ICD-9 Finland
Other complications of procedures, not elsewhere classified, Haemorrhage or haematoma complicating a procedure
11.1
6.8
12
11
D69.8
ICD-10 Finland
Other specified haemorrhagic conditions
40.6
6.8
8
*
M54.5
ICD-10 Finland
Low back pain
1.7
6.7
185
1303
G47.3
ICD-10 Finland
Sleep apnoea
1.9
6.7
102
606
EBB10
NOMESCO Finland
Insertion of dental implant
6.6
6.7
16
25
R03BA02
ATC
budesonide; inhalant
1.9
6.7
101
599
N02CC04
ATC
rizatriptan; oral
2.4
6.6
45
196
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.0
6.6
73
390
LC2BE
NOMESCO Finland
Transvaginal ultrasound examination of uterus, parametria and lower abdomen
1.7
6.5
183
1292
C07AA05
ATC
propranolol; systemic
1.8
6.4
121
766
Z01.1
ICD-10 Finland
Examination of ears and hearing
2.0
6.4
70
371
M51.3
ICD-10 Finland
Other specified intervertebral disc degeneration
2.4
6.4
44
193
J02AC01
ATC
fluconazole; systemic
1.6
6.4
234
1766
R01AD09
ATC
mometasone; nasal
1.6
6.4
253
1946
R06AE07
ATC
cetirizine; oral
1.6
6.3
239
1815
M79.7
ICD-10 Finland
Fibromyalgia
2.9
6.3
29
104
D68.1
ICD-10 Finland
Hereditary factor XI deficiency
+∞
6.3
6
*
O991, D680,
ICD-10 Finland
+∞
6.3
6
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.8
6.2
111
691
C07AB07
ATC
bisoprolol; oral
1.6
6.2
182
1297
K92.1
ICD-10 Finland
Melaena
3.1
6.2
26
88
SPAT1104
SPAT
Monitoring of emergency patient
2.7
6.2
32
122
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.9
6.2
29
105
UDH02
NOMESCO Finland
Rhinopharyngoscopy
2.4
6.1
42
184
Z2221
NOMESCO Finland
Medical doctor
1.7
6.1
147
995
Z00.0
ICD-10 Finland
General medical examination
1.8
6.1
101
615
A03FA01
ATC
metoclopramide; systemic, rectal
1.8
6.1
116
736
R06.0
ICD-10 Finland
Dyspnoea
1.7
6.0
118
754
R06AX27
ATC
desloratadine; oral
1.6
6.0
174
1234
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
190
7
438.03
202.51
5.6
1.3
82.99
152.71
%
—
178
7
261
476
10.46
155.86
3.6
1.9
30.91
29.19
s
4.54
250
459
(3011547) Coagulation factor VII activity actual/normal in Platelet poor plasma by Coagulation assay
65
14
53.28
112.33
1.3
1.0
116.22
138.93
%
0.97
58
14
61
14
49.54
103.80
1.2
1.0
94.58
96.38
%
—
26
8
59
14
47.70
99.55
1.2
1.0
100.65
104.50
%
—
26
8
247
949
4.19
54.70
5.7
3.2
100.35
96.44
%
1.59
237
919
46
0
+∞
48.76
1.5
0.0
50.92
—
%
—
40
0
111
290
4.64
40.00
2.6
2.3
85.52
75.70
ml/min/173m2
1.72
85
102
139
477
3.66
33.92
4.2
2.1
2.47
2.47
g/l
0.00
134
437
208
931
3.13
32.69
3.3
1.8
0.60
0.82
mg/l
2.02
158
703
145
531
3.45
31.77
4.2
2.1
14.72
14.02
umol/l
0.55
140
489
273
1479
2.88
29.48
5.0
4.1
37.33
36.54
g/l
1.58
256
1388
151
629
3.01
26.03
3.4
2.5
2.43
2.44
mmol/l
0.53
144
548
236
1297
2.56
23.14
3.4
3.0
2.36
2.36
mmol/l
0.37
222
1160
255
1468
2.52
22.44
9.2
8.2
1.11
1.11
inr
0.01
99
472
190
965
2.57
21.70
4.0
2.0
2.88
2.99
mg/l
0.22
170
822
398
3018
2.61
16.59
7.6
6.5
75.23
76.97
u/l
0.40
381
2843
288
1929
2.18
15.77
5.2
5.4
10.45
9.83
umol/l
0.21
271
1824
333
2383
2.21
15.12
9.1
8.5
3.93
3.93
e9/l
0.02
306
2081
267
1756
2.13
15.09
6.4
5.8
1.22
1.22
mmol/l
0.27
230
1495
242
1571
2.06
13.75
5.5
5.1
1.22
1.22
mmol/l
0.16
229
1441
390
3048
2.31
13.22
4.5
3.9
9.28
10.32
mm/h
0.88
373
2826
285
1998
2.00
12.69
7.0
5.6
28.94
29.34
%
0.25
275
1886
12
0
+∞
12.55
1.4
0.0
—
—
—
0
0
204
1284
2.00
12.27
2.9
2.9
—
—
—
0
0
294
2106
1.97
12.05
4.7
2.8
90.48
74.45
ug/l
0.92
279
1961
280
1980
1.95
11.84
6.6
5.4
56.96
56.48
%
0.28
270
1866
137
756
2.12
11.72
2.2
2.4
7.28
7.91
e6/l
0.14
124
673
295
2153
1.91
11.02
4.3
3.9
6.26
6.49
mmol/l
1.26
278
1961
177
1099
1.95
10.77
2.7
2.8
27.41
114.94
e6/l
0.78
141
816
161
981
1.95
10.27
2.7
2.7
0.31
0.35
e6/l
0.18
131
713
472
4175
3.70
10.09
15.8
10.9
19.88
20.25
mg/l
0.08
414
3182
403
3411
1.97
7.99
5.5
4.1
14.55
14.46
pmol/l
0.30
387
3162
255
1918
1.68
7.37
3.4
2.4
—
—
—
0
0
88
506
1.90
6.39
2.2
1.7
—
—
—
0
0
165
1154
1.64
6.03
2.3
2.3
54.11
59.06
u/l
1.15
154
1072
175
1255
1.61
5.72
2.9
3.0
21.81
61.61
ng/l
0.60
89
701
229
1756
1.56
5.59
2.8
2.3
75.55
76.07
nmol/l
0.10
218
1600
192
1414
1.58
5.59
1.9
1.8
103.51
97.74
pmol/l
0.68
97
724
114
740
1.70
5.48
2.5
2.8
1303.48
774.81
ng/l
0.65
94
619
56
293
2.03
5.32
5.6
7.3
5.29
5.16
kpa
0.40
56
281
63
344
1.95
5.31
2.0
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
20
64
3.21
5.25
3.5
3.1
0.20
0.38
u/ml
2.89
15
32
153
1084
1.59
5.18
1.8
1.6
—
—
—
0
0
474
4415
2.66
5.13
12.3
8.9
25.14
24.97
u/l
0.08
469
4287
58
312
1.97
5.11
1.4
1.2
78.38
223.55
u/ml
1.18
53
290
255
2030
1.53
5.10
4.3
3.3
0.00
0.00
estimate
-0.00
67
430
152
1082
1.58
5.02
4.8
3.6
0.00
0.00
estimate
0.50
66
412
439
3980
1.90
4.99
6.2
4.8
1.79
2.07
mu/l
0.46
421
3725
55
297
1.96
4.79
3.3
3.8
4.45
4.66
pmol/l
0.87
48
262
132
923
1.59
4.66
2.9
2.0
—
—
—
0
0
60
338
1.88
4.62
1.9
1.7
—
—
—
0
0
35
161
2.26
4.61
8.2
7.2
24.90
25.05
mmol/l
0.11
35
154
426
3859
1.74
4.43
14.3
9.8
90.04
88.36
ml/min/173m2
0.89
382
3121
53
291
1.92
4.41
5.7
7.4
0.88
1.40
mmol/l
0.35
42
237
316
2677
1.50
4.40
5.3
4.0
224.86
1438.98
e6/l
—
7
43
180
1363
1.50
4.39
2.8
2.9
27.01
29.15
u/l
0.68
173
1303
43
221
2.04
4.31
1.6
1.5
—
—
—
0
0
51
279
1.92
4.29
4.0
3.6
1.23
1.23
mmol/l
0.11
46
236
204
1592
1.48
4.26
4.5
3.4
—
—
—
0
0
153
1129
1.51
4.19
1.4
1.3
0.63
1.53
u/ml
1.46
55
314
21
81
2.66
4.02
1.5
1.6
—
—
—
0
0
14
36
3.97
4.02
2.2
2.0
91.29
91.77
%
0.12
14
36
252
2068
1.44
3.96
4.3
3.3
0.00
0.02
estimate
0.80
66
398
20
76
2.70
3.94
1.5
1.7
—
—
—
0
0
249
2044
1.44
3.88
5.6
4.5
0.00
0.00
estimate
0.50
65
410
369
3270
1.50
3.78
3.7
3.5
—
—
—
0
0
112
792
1.53
3.69
1.3
1.3
38.44
16.04
u/ml
0.26
44
325
8
12
6.75
3.68
2.8
2.5
60.82
90.24
ug/l
—
8
12
59
356
1.75
3.65
6.8
5.9
104.25
104.47
mmol/l
0.14
59
356
124
899
1.51
3.63
3.0
2.5
319.47
5117.30
umol/l
3.41
109
806
67
424
1.67
3.49
2.4
2.7
9.61
7.27
umol/l
0.17
57
361
35
184
1.97
3.33
1.5
1.3
—
—
—
0
0
121
888
1.48
3.32
4.9
3.4
1.02
1.02
kg/l
0.72
18
116
9
19
4.80
3.25
1.0
1.1
1845.89
1744.37
miu/ml
—
9
19
327
2872
1.41
3.19
3.0
2.9
38.89
38.89
u/l
0.00
305
2732
19
79
2.46
3.17
1.1
1.1
—
—
—
0
0
82
559
1.56
3.17
2.5
2.4
0.56
1.04
e6/l
2.06
49
294
111
815
1.47
3.02
1.4
1.3
26.86
31.72
iu/ml
0.14
34
277
29
148
2.02
3.01
1.7
1.4
13.53
11.38
u/l
0.17
22
119
15
57
2.68
2.99
1.7
1.6
—
—
—
0
0
15
57
2.68
2.99
1.7
1.6
—
—
—
0
0
15
57
2.68
2.99
1.7
1.6
—
—
—
0
0
88
618
1.52
2.97
3.3
3.0
484.08
255.09
ng/l
0.26
49
386
137
1059
1.41
2.80
1.6
1.6
1.57
1.34
mmol/l
1.82
119
921
12
39
3.13
2.79
1.8
1.6
—
—
—
0
0
12
39
3.13
2.79
1.8
1.6
—
—
—
0
0
13
49
2.70
2.64
1.6
1.5
—
—
—
0
0
18
80
2.30
2.63
4.6
3.9
57.44
56.67
%
0.07
18
80
54
351
1.60
2.56
3.3
2.9
—
—
—
0
0
14
56
2.54
2.55
1.6
1.9
—
—
—
0
0
20
96
2.13
2.46
1.5
1.5
—
—
—
0
0
47
299
1.63
2.44
2.4
2.3
4450.52
3989.08
u/l
0.04
15
134
75
535
1.47
2.35
2.5
2.5
2.12
3.52
e6/l
1.49
42
269
43
270
1.65
2.35
3.4
3.4
79.55
69.44
ng/l
0.35
38
245
52
343
1.58
2.34
2.0
2.4
29.72
32.29
u/l
0.33
46
296
486
4718
2.49
2.27
26.8
16.5
4.48
4.48
e12/l
0.03
486
4611
17
79
2.19
2.27
3.8
3.6
4.63
4.38
e9/l
0.13
17
79
28
157
1.83
2.26
1.9
1.8
—
—
—
0
0
59
404
1.52
2.26
2.2
1.7
—
—
—
0
0
486
4720
2.47
2.23
27.0
16.6
133.83
134.10
g/l
0.17
486
4666
10
36
2.81
2.15
1.4
1.1
0.45
0.41
u/ml
—
5
13
36
223
1.66
2.09
1.8
1.6
—
—
—
0
0
11
43
2.59
2.09
1.8
1.6
—
—
—
0
0
25
139
1.84
2.09
1.7
1.3
—
—
—
0
0
485
4714
2.30
2.08
26.7
16.5
40.13
40.04
%
0.16
468
4473
429
4049
1.44
2.07
4.3
3.9
4.74
4.79
mmol/l
0.55
405
3813
25
140
1.83
2.05
1.5
1.1
—
—
—
0
0
12
50
2.43
2.04
1.6
1.5
—
—
—
0
0
24
134
1.83
1.99
3.0
1.8
—
—
—
0
0
11
45
2.48
1.94
1.2
1.1
—
—
—
0
0
70
515
1.42
1.89
2.3
1.8
—
—
—
0
0
132
1076
1.31
1.86
2.8
3.0
7.16
7.58
mmol/l
0.51
115
949
34
215
1.62
1.85
2.3
2.2
4.24
5.62
ug/l
0.32
29
189
6
17
3.56
1.84
1.0
1.4
—
—
—
0
0
8
29
2.79
1.80
1.9
1.6
—
—
—
0
0
12
54
2.25
1.75
1.6
1.6
—
—
—
0
0
9
36
2.53
1.74
1.8
1.5
—
—
—
0
0
17
89
1.94
1.72
1.2
1.3
—
—
—
0
0
27
164
1.68
1.72
1.5
1.6
—
—
—
0
0
14
68
2.09
1.71
1.3
1.2
6.67
3.62
u/ml
—
6
26
430
4093
1.38
1.66
4.6
4.3
2.80
2.85
mmol/l
0.55
405
3834
15
76
2.00
1.66
1.3
1.1
—
—
—
0
0
11
49
2.27
1.64
1.1
1.1
—
—
—
0
0
5
14
3.60
1.62
1.4
3.9
—
—
—
0
0
424
4032
1.36
1.60
4.2
3.8
1.48
1.54
mmol/l
2.23
399
3783
22
129
1.74
1.59
2.9
1.7
—
—
—
0
0
6
20
3.02
1.58
2.3
1.4
14.23
25.82
ug/l
—
6
20
25
153
1.67
1.56
1.3
1.8
—
—
—
0
0
13
64
2.06
1.55
1.2
1.1
—
—
—
0
0
55
403
1.41
1.54
1.3
1.2
162.36
151.35
iu/ml
0.07
21
168
104
842
1.30
1.53
2.3
2.1
—
—
—
0
0
7
27
2.61
1.52
1.9
1.6
—
—
—
0
0
7
27
2.61
1.52
1.9
1.6
—
—
—
0
0
7
27
2.61
1.52
1.9
1.6
—
—
—
0
0
6
21
2.88
1.51
1.0
1.0
—
—
—
0
0
95
765
1.30
1.46
2.2
2.0
—
—
—
0
0
5
16
3.15
1.44
1.0
1.4
—
—
—
0
0
6
22
2.75
1.44
2.7
3.5
—
—
—
0
0
14
74
1.92
1.40
1.7
4.7
—
3.05
—
0
8
7
29
2.43
1.39
1.0
1.4
67.29
65.90
umol/l
—
7
29
23
143
1.64
1.37
1.8
2.0
2.00
6.02
iu/l
2.76
11
50
9
41
2.22
1.37
2.0
2.1
—
—
—
0
0
24
151
1.62
1.37
1.5
1.4
1.11
1.24
g/l
1.72
24
146
5
17
2.96
1.36
1.0
1.5
—
—
—
0
0
410
3903
1.29
1.36
4.3
3.9
5.70
5.74
mmol/l
0.21
375
3608
23
144
1.63
1.34
1.4
1.5
0.21
0.25
g/l
1.57
23
139
55
414
1.37
1.33
6.2
5.4
—
—
—
0
0
37
260
1.46
1.31
3.8
5.9
1.19
1.28
mmol/l
0.39
37
251
44
322
1.40
1.27
1.7
1.4
21.49
27.00
iu/l
0.62
38
272
8
36
2.24
1.24
4.1
1.6
—
—
—
0
0
406
3875
1.26
1.21
3.9
3.5
1.36
1.22
mmol/l
2.72
383
3619
6
26
2.32
1.19
1.2
1.5
—
—
—
0
0
14
79
1.79
1.18
1.9
1.8
—
—
—
0
0
8
39
2.07
1.15
1.4
1.6
—
—
—
0
0
20
127
1.60
1.13
1.3
1.2
—
—
—
0
0
7
32
2.20
1.08
1.3
1.2
—
—
—
0
0
10
52
1.94
1.07
1.3
1.1
—
—
—
0
0
380
3620
1.21
1.04
5.3
4.8
38.02
38.57
mmol/mol
0.60
349
3416
10
53
1.91
1.02
1.3
1.1
—
—
—
0
0
9
48
1.89
1.01
1.2
1.1
—
—
—
0
0
9
48
1.89
1.01
2.9
2.6
26.88
38.88
u/ml
—
9
48
7
35
2.01
1.00
1.7
1.3
—
—
—
0
0
7
35
2.01
1.00
1.0
1.2
—
—
—
0
0
13
76
1.73
0.99
1.1
1.2
140.00
231.18
u/ml
—
8
48
68
554
1.26
0.98
1.8
1.6
1097.54
1173.56
nmol/l
0.31
54
413
7
36
1.96
0.97
1.0
1.0
—
—
—
0
0
7
36
1.96
0.97
1.0
1.3
—
—
—
0
0
97
826
1.22
0.94
1.6
1.5
23.37
21.63
nmol/l
0.47
87
709
6
27
2.24
0.93
1.0
1.1
—
—
—
0
0
12
70
1.73
0.93
1.4
1.3
91.40
120.93
u/ml
—
5
15
27
194
1.41
0.90
2.7
3.2
1.61
1.29
mmol/l
0.17
19
142
19
127
1.52
0.90
1.3
1.2
—
—
—
0
0
13
79
1.66
0.89
1.1
1.2
—
—
—
0
0
110
957
1.19
0.86
3.5
3.8
8.00
9.72
mg/mmol
0.22
67
586
17
113
1.52
0.83
2.3
2.0
—
—
—
0
0
17
113
1.52
0.83
2.3
2.0
6.81
7.43
g/l
0.77
17
107
17
113
1.52
0.83
2.3
2.0
3.28
3.68
g/l
0.85
17
107
16
105
1.54
0.82
2.4
2.1
2.77
2.94
g/l
0.56
16
99
16
106
1.53
0.80
2.4
2.1
9.88
10.14
g/l
0.10
16
99
36
280
1.31
0.76
1.4
1.3
—
—
—
0
0
9
53
1.71
0.75
1.9
1.4
—
—
—
0
0
12
75
1.61
0.75
1.7
2.6
24.93
24.72
mmol/l
0.07
12
75
5
24
2.09
0.74
1.2
1.6
—
—
—
0
0
5
25
2.01
0.73
1.0
1.4
1.56
1.58
g/l
—
5
25
13
84
1.56
0.72
1.1
1.4
—
—
—
0
0
7
41
1.72
0.70
1.9
1.5
—
—
—
0
0
12
77
1.57
0.69
1.3
1.5
3613.60
11534.56
e6/l
—
5
52
18
128
1.42
0.66
1.3
1.4
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
5
28
1.79
0.66
1.2
1.1
—
—
—
0
0
10
62
1.63
0.65
1.8
1.3
—
—
—
0
0
28
217
1.31
0.63
1.7
1.5
—
—
—
0
0
8
49
1.64
0.62
1.0
1.2
—
—
—
0
0
5
30
1.67
0.61
1.0
1.6
0.88
0.95
g/l
—
5
30
5
30
1.67
0.61
1.2
1.2
—
—
—
0
0
64
550
1.19
0.60
1.5
1.6
1.48
1.37
%
0.51
55
499
28
220
1.29
0.58
1.6
1.4
—
—
—
0
0
14
98
1.44
0.57
2.7
2.3
1.06
0.71
g/l
0.22
14
90
13
90
1.46
0.56
1.5
1.1
—
12.08
—
0
5
6
38
1.59
0.54
1.2
1.2
—
—
—
0
0
13
91
1.44
0.53
2.3
2.1
40.44
38.86
g/l
0.66
13
85
6
39
1.54
0.53
1.0
1.0
1.39
1.36
g/l
—
6
34
12
83
1.46
0.52
3.8
2.9
7.54
8.55
kpa
0.88
12
83
10
68
1.48
0.47
1.3
1.3
—
—
—
0
0
10
68
1.48
0.47
1.3
1.3
—
—
—
0
0
7
50
1.41
0.45
1.9
1.7
8.44
82.31
u/ml
—
7
50
26
211
1.25
0.44
1.6
1.6
—
—
—
0
0
14
104
1.36
0.43
1.5
1.3
340.62
322.53
ug/g
—
9
61
36
423
0.84
0.43
3.5
3.9
28.12
32.86
%
1.44
24
294
8
57
1.41
0.42
1.4
1.4
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.1
—
24.77
—
0
15
5
34
1.48
0.40
1.2
1.1
—
72.20
—
0
5
33
279
1.20
0.40
6.6
3.5
1.85
1.89
mmol/l
0.03
28
225
14
107
1.32
0.37
2.1
2.8
9.48
10.03
mg/l
0.20
14
99
17
134
1.28
0.37
3.9
2.9
50.72
50.57
%
0.01
17
134
19
153
1.25
0.36
2.9
2.0
10.86
11.64
nmol/l
0.19
19
142
9
122
0.73
0.35
1.9
1.6
—
—
—
0
0
23
191
1.21
0.34
2.5
2.5
0.10
0.16
e6/l
0.37
23
184
10
75
1.34
0.30
3.0
2.1
—
—
—
0
0
8
107
0.74
0.29
1.0
1.2
—
—
—
0
0
47
422
1.13
0.29
1.8
1.5
—
—
—
0
0
8
62
1.30
0.28
1.3
1.3
—
—
—
0
0
8
63
1.27
0.28
2.1
2.1
131.75
131.41
g/l
—
8
46
8
64
1.25
0.27
1.3
1.1
—
—
—
0
0
9
77
1.17
0.24
1.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
5
43
1.16
0.21
1.2
1.4
—
—
—
0
0
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.9
—
—
—
0
0
18
158
1.14
0.16
1.8
1.6
—
—
—
0
0
11
92
1.20
0.16
1.1
1.1
0.96
2.02
u/ml
—
5
49
35
323
1.09
0.15
2.4
4.1
3.64
22.02
ug/l
0.74
25
255
16
141
1.14
0.14
2.4
2.4
1.59
1.21
%
1.17
16
141
17
190
0.89
0.13
1.4
1.9
—
—
—
0
0
24
220
1.10
0.12
1.3
1.3
123.65
257.22
miu/ml
1.83
11
116
49
467
1.05
0.10
1.3
1.6
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
5
46
1.09
0.09
1.0
1.2
—
—
—
0
0
10
114
0.87
0.09
1.3
1.1
3.14
2.07
u/ml
—
5
59
5
47
1.06
0.09
1.2
1.2
—
—
—
0
0
26
278
0.93
0.09
1.7
1.5
—
—
—
0
0
15
136
1.11
0.08
2.5
2.4
0.73
0.69
%
0.18
15
136
77
746
1.04
0.08
2.1
1.6
503.08
19099821.89
pmol/l
0.78
66
644
6
58
1.03
0.08
1.2
1.2
—
—
—
0
0
6
74
0.81
0.07
1.5
1.8
13.32
13.24
%
—
6
74
28
269
1.04
0.04
3.6
3.5
24.99
21.83
%
0.48
13
104
105
1063
0.98
0.03
1.6
1.5
—
—
—
0
0
24
249
0.96
0.02
1.7
1.5
—
—
—
0
0
18
186
0.97
0.00
1.9
1.7
—
—
—
0
0
22
225
0.98
0.00
1.5
1.8
4.09
2.91
mg/l
0.28
17
165
28
275
1.02
0.00
1.1
1.0
—
—
—
0
0
23
227
1.01
0.00
1.7
1.4
—
—
—
0
0
23
227
1.01
0.00
1.7
1.4
—
—
—
0
0
20
198
1.01
0.00
2.9
2.4
0.48
0.69
ug/l
1.58
13
104
23
228
1.01
0.00
1.7
1.4
—
—
—
0
0
23
228
1.01
0.00
1.7
1.4
—
—
—
0
0
5
50
1.00
-0.00
1.2
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
6
63
0.95
-0.00
1.2
1.1
128.83
120.07
%
—
6
56
0
5
0.00
-0.00
0.0
1.0
—
76.80
—
0
5
0
8
0.00
-0.00
0.0
1.1
—
1.20
—
0
8
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint D3_VONVILLEBRAND and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_VONVILLEBRAND | 1.504 [1.17, 1.94] | 0.002 |
| Birth year | 0.996 [0.99, 1.0] | 0.303 |
During the follow-up period (1.1.1998 — 31.12.2019), 103 out of 1902 females with D3_VONVILLEBRAND died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| D3_VONVILLEBRAND | 1.609 [1.22, 2.12] | < 0.001 |
| Birth year | 0.988 [0.98, 1.0] | 0.013 |
During the follow-up period (1.1.1998 — 31.12.2019), 80 out of 821 males with D3_VONVILLEBRAND died.
Mortality risk
Mortality risk for people of age
years, who have D3_VONVILLEBRAND.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.137% | 0.35% |
| 5 | 0.906% | 2.071% |
| 10 | 2.221% | 5.037% |
| 15 | 4.34% | 9.326% |
| 20 | 7.565% | 15.692% |
Relationships between endpoints
↥Index endpoint: D3_VONVILLEBRAND – Von Willebrand disease
GWS hits: 10
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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