Circumscribed brain atrophy

G6_ATROPHCIRCUM

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G31.0
  • Hospital discharge: ICD-9 3311
  • Hospital discharge: ICD-8 34791
  • Cause of death: ICD-10 G31.0
  • Cause of death: ICD-9 3311
  • Cause of death: ICD-8 34791

2 out of 7 registries used, show all original rules.

787

4. Check minimum number of events

None

787

5. Include endpoints

None

787

6. Filter based on genotype QC (FinnGen only)

766

Control definitions (FinnGen only)

Control exclude
G6_NEURODEG

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF6
Parent code in ICD-10
G31
Name in latin
Atrophia cerebri circumscripta

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 9185 4538 4462
Only index persons 6588 3580 3008
Unadjusted period prevalence (%)
Whole population 0.13 0.13 0.12
Only index persons 0.12 0.13 0.11
Median age at first event (years)
Whole population 66.45 69.56 63.74
Only index persons 69.18 70.86 67.17

-FinnGen-

Key figures

All Female Male
Number of individuals 766 349 417
Unadjusted period prevalence (%) 0.16 0.12 0.19
Median age at first event (years) 68.22 69.17 67.41

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
787
Matched controls
7870
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G31.0
ICD-10 Finland
Circumscribed brain atrophy
4842.7
307.7
563
*
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
11.3
229.3
308
424
N05AX08
ATC
risperidone; systemic
12.9
217.7
248
271
F03
ICD-10 Finland
Unspecified dementia
15.5
195.7
188
156
XA800
NOMESCO Finland
Neuropsychological investigation
20.7
192.5
155
92
TAB00
NOMESCO Finland
Lumbar puncture
17.4
188.2
167
120
F02.09*G31.0
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
+∞
180.3
166
*
N05AH04
ATC
quetiapine; oral
6.4
124.0
271
601
N05AH03
ATC
olanzapine; systemic
11.7
123.8
138
141
34791
ICD-8 Finland
Other disease of brain, Atrophia cerebri
+∞
122.1
114
*
N06DX01
ATC
memantine; oral
10.8
116.9
137
150
N03AG01
ATC
valproic acid; systemic, rectal
9.4
102.3
134
169
N06DA02
ATC
donepezil; oral
10.3
98.1
118
133
G30.1
ICD-10 Finland
Alzheimer disease with late onset
13.6
93.2
91
75
P20
ICPC
Memory disturbance
5.0
91.3
259
703
P70
ICPC
Dementia
14.7
87.3
81
61
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
52.2
84.8
49
10
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.9
75.2
156
319
Z2445
NOMESCO Finland
Psychologist
11.3
72.3
79
77
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
19.7
72.3
57
31
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
6.5
70.0
126
224
F06.7
ICD-10 Finland
Mild cognitive disorder
8.6
62.4
84
108
A28
ICPC
Limited function/disability NOS
3.6
61.3
277
1020
N06DA03
ATC
rivastigmine; oral, transdermal
8.2
58.7
82
110
R41.3
ICD-10 Finland
Other amnesia
8.6
56.3
75
95
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
5.6
50.6
104
208
G31.9
ICD-10 Finland
Degenerative disease of nervous system, unspecified
266.6
49.7
50
*
R47.0
ICD-10 Finland
Dysphasia and aphasia
13.7
45.4
43
33
N05BA06
ATC
lorazepam; systemic, sublingual
5.1
45.0
102
222
IBZ01
NOMESCO Finland
Profession-specific psychiatric evaluation
13.5
42.0
40
31
N19
ICPC
Speech disorder
11.9
40.8
42
37
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.4
39.6
83
168
N06AX11
ATC
mirtazapine; oral
2.7
37.8
335
1720
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.9
36.9
88
199
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.5
36.9
98
242
R41.0
ICD-10 Finland
Disorientation, unspecified
6.4
36.8
63
105
N05BA04
ATC
oxazepam; oral
2.7
36.3
272
1280
N06AB10
ATC
escitalopram; oral
3.1
36.1
180
679
N05AD01
ATC
haloperidol; systemic
6.4
36.0
62
104
F02.09
ICD-10 Finland
Dementia in Pick's disease without information on additional symptoms
+∞
35.7
34
*
G31.8
ICD-10 Finland
Other specified degenerative diseases of nervous system
97.0
34.0
37
*
F29
ICD-10 Finland
Unspecified nonorganic psychosis
7.8
32.5
46
62
G30.0
ICD-10 Finland
Alzheimer disease with early onset
+∞
32.5
31
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.5
30.9
122
397
IGY02
NOMESCO Finland
Psychiatric monitoring contact
9.2
30.0
37
42
AA1AD
NOMESCO Finland
CT of head and brain
2.4
29.1
301
1619
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
9.3
28.8
35
39
N99
ICPC
Neurological disease other
11.5
28.6
30
27
N05AX12
ATC
aripiprazole; systemic
8.3
28.3
38
48
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.6
28.1
55
104
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
5.9
27.7
51
91
F22.0
ICD-10 Finland
Delusional disorder
10.4
27.5
31
31
ZY010
NOMESCO Finland
Hospital outpatient
5.2
27.4
58
118
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
8.8
26.8
34
40
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
26.2
226
1112
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
25.6
99
317
WYA20
NOMESCO Finland
Home visit
7.9
25.2
35
46
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
24.3
318
1856
R4130
NOMESCO Finland
Speech therapy
6.0
23.9
43
75
F05.9
ICD-10 Finland
Delirium, unspecified
6.1
23.8
42
72
SPAT1053
SPAT
Memory test
2.5
23.2
179
832
SPAT1216
SPAT
Assessment of functional ability
2.5
22.9
184
871
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
4.3
22.6
60
147
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
22.1
101
357
ICB03
NOMESCO Finland
Psychiatric treatment plan, monitoring
8.8
22.0
28
33
ZY000
NOMESCO Finland
Hospital inpatient
9.2
21.3
26
29
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.9
20.9
63
170
N03AE01
ATC
clonazepam; systemic
3.6
20.6
71
210
IAA01
NOMESCO Finland
Assessment of need for psychiatric treatment
8.0
20.5
28
36
F0203, G310,
ICD-10 Finland
+∞
19.9
19
*
AA5DR
NOMESCO Finland
Brain metabolism PET with CT
204.9
19.6
20
*
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
6.2
19.2
33
55
G31.2
ICD-10 Finland
Degeneration of nervous system due to alcohol
56.5
19.0
22
*
A06AD11
ATC
lactulose; oral
2.2
18.2
181
930
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.8
18.0
57
159
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.7
18.0
58
164
R53
ICD-10 Finland
Malaise and fatigue
2.1
17.8
217
1206
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.6
17.8
60
175
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.6
17.6
61
181
P99
ICPC
Psychological disorders other
6.0
17.6
31
53
N06AB04
ATC
citalopram; systemic
2.2
17.5
191
1016
IAB14
NOMESCO Finland
Geriatric psychiatry consultation
35.9
16.7
21
6
F0200, G310,
ICD-10 Finland
+∞
16.7
16
*
F0204, G310,
ICD-10 Finland
+∞
16.7
16
*
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
18.4
16.5
25
14
S01.0
ICD-10 Finland
Open wound of scalp
2.7
16.5
95
379
N03AX09
ATC
lamotrigine; oral
4.4
16.4
42
100
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
6.9
16.2
25
37
N06AX26
ATC
vortioxetine; oral
3.6
16.2
56
166
G30.8
ICD-10 Finland
Other Alzheimer disease
19.0
16.1
24
13
IBZ07
NOMESCO Finland
Neurological assessment in psychiatry
48.6
16.1
19
*
ICC04
NOMESCO Finland
Psychiatric treatment plan, permanent discontinuation
12.6
15.9
28
23
P29
ICPC
Psychological sympt/compl other
3.9
15.6
46
122
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
6.8
15.4
24
36
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
6.2
15.2
26
43
N05AN01
ATC
lithium; oral
5.9
15.0
27
47
S06.0
ICD-10 Finland
Concussion
2.5
14.3
101
445
N29
ICPC
Neurological sympt/complt other
5.6
14.1
27
50
IGY99
NOMESCO Finland
Other psychiatric treatment contact
13.0
14.0
24
19
N05AF03
ATC
chlorprothixene; systemic
5.0
13.9
30
62
F00.20*G30.8
ICD-10 Finland
Dementia in Alzheimer's disease, atypical or mixed type without additional symptoms
6.0
13.6
24
41
U04
ICPC
Incontinence urine
2.9
13.5
67
247
G31.1
ICD-10 Finland
Senile degeneration of brain, not elsewhere classified
142.4
13.5
14
*
G31
ICD-10 Finland
Other degenerative diseases of nervous system, not elsewhere classified
142.4
13.5
14
*
ZXY02
NOMESCO Finland
Neuropsychologist
21.6
13.4
19
9
G12.2
ICD-10 Finland
Motor neuron disease
11.7
13.4
24
21
SPAT1224
SPAT
Implementation of speech therapy rehabilitation plan
5.9
13.3
24
42
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
4.2
12.9
35
87
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
11.8
12.9
23
20
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
10.7
12.8
24
23
W19
ICD-10 Finland
Unspecified fall
2.4
12.8
99
454
P74
ICPC
Anxiety disorder/anxiety state
4.5
12.7
31
71
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.3
12.6
33
80
F02.00
ICD-10 Finland
Dementia in Pick's disease without additional symptoms
+∞
12.5
12
*
A04
ICPC
Weakness/tiredness general
2.1
12.4
132
688
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
2.9
12.4
59
212
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.1
12.3
53
180
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.0
12.3
54
186
RT250, ,
NOMESCO Finland
47.4
11.9
14
*
F00.00*G30.0
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, presenile onset without additional symptoms
47.4
11.9
14
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
11.8
253
1662
A29
ICPC
General symptom/complaint other
2.1
11.7
123
638
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.5
11.7
75
315
IER02
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, group
16.7
11.7
18
11
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
3.1
11.6
50
170
G30
ICD-10 Finland
Alzheimer disease
23.3
11.6
16
7
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
11.3
11.6
21
19
N05AL01
ATC
sulpiride; systemic
5.8
11.5
21
37
ZXY03
NOMESCO Finland
Occupational therapist
+∞
11.5
11
*
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
11.3
146
815
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
4.8
11.2
25
53
L28
ICPC
Limited function/disability (L)
1.9
11.2
174
1033
P28
ICPC
Limited function/disability (P)
17.3
11.2
17
10
78020
ICD-8 Finland
Certain symptoms referable to nervous system and special senses, Convulsions
17.3
11.2
17
10
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
0.4
11.2
69
1467
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.7
11.1
36
102
N05AA02
ATC
levomepromazine; systemic
3.2
11.0
44
143
183
Kela drug reimbursment
Lamotrigin and topiramate
14.1
11.0
18
13
SPAT1234
SPAT
Support of social functional capacity
2.8
10.6
56
213
RT150, ,
NOMESCO Finland
60.8
10.6
12
*
N05AB03
ATC
perphenazine; systemic, rectal
3.6
10.5
35
101
F0201, G310,
ICD-10 Finland
+∞
10.4
10
*
F0202, G310,
ICD-10 Finland
+∞
10.4
10
*
SPAT1307
SPAT
Psychosocial counselling and guidance
4.0
10.4
29
74
N05BA01
ATC
diazepam; systemic, rectal
2.0
10.4
122
659
ZYB04
NOMESCO Finland
Outreach service in patient’s home or everyday environment
33.0
10.4
13
*
N06AX16
ATC
venlafaxine; oral
2.2
10.3
98
488
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
23.7
10.3
14
6
F00.9
ICD-10 Finland
Dementia in Alzheimer disease, unspecified
40.6
10.0
12
*
N05CD07
ATC
temazepam; oral
1.9
10.0
130
727
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
9.9
126
698
IGP01
NOMESCO Finland
Psychiatric family contact
26.4
9.8
13
5
F80.1
ICD-10 Finland
Expressive language disorder
10.8
9.8
18
17
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.9
9.7
144
840
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.4
9.6
71
318
F20.9
ICD-10 Finland
Schizophrenia, unspecified
5.1
9.6
20
40
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
7.3
9.6
22
31
-, ,
ICD-10 Finland
3.8
9.5
29
79
F06.4
ICD-10 Finland
Organic anxiety disorder
101.2
9.4
10
*
ZXY01
NOMESCO Finland
Chief Physician, Head of Department or Deputy Chief Physician
17.8
9.4
14
8
R47.8
ICD-10 Finland
Other and unspecified speech disturbances
5.2
9.4
19
37
F062, G310,
ICD-10 Finland
+∞
9.4
9
*
F064, G310,
ICD-10 Finland
+∞
9.4
9
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.4
9.3
68
303
IAB01
NOMESCO Finland
Psychiatric pharmacotherapy consultation
10.8
9.3
17
16
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.0
9.3
41
142
N28
ICPC
Limited function/disability (N)
4.4
9.2
23
54
N05CF01
ATC
zopiclone; oral
1.6
9.1
282
2015
N06DA04
ATC
galantamine; oral
4.1
9.1
25
63
N06AB06
ATC
sertraline; oral
2.2
9.0
77
367
IBZ02
NOMESCO Finland
Somatic assessment of psychiatric patient
37.1
9.0
11
*
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
2.8
9.0
45
167
Z3226
NOMESCO Finland
Physiotherapist
1.8
8.9
157
965
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
8.8
102
1756
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
2.5
8.8
55
229
G40
ICD-10 Finland
Epilepsy
9.1
8.6
17
19
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
4.2
8.5
22
53
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
5.0
8.4
18
37
F0633, G310,
ICD-10 Finland
+∞
8.3
8
*
F61.0
ICD-10 Finland
Mixed personality disorders
9.6
8.3
16
17
N05AH02
ATC
clozapine; systemic
7.2
8.3
19
27
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
6.6
8.2
20
31
SPAT1254
SPAT
Administration of medicine
1.8
8.1
130
774
SPAT1229
SPAT
Assessment of need for aid
2.1
8.1
78
390
R55
ICD-10 Finland
Syncope and collapse
1.9
8.1
108
607
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.1
8.0
82
421
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.3
7.9
29
90
D21
ICPC
Swallowing problem
4.1
7.8
21
52
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.1
7.8
32
106
AA400
NOMESCO Finland
Electroconvulsive therapy
15.2
7.7
12
8
ZXE01
NOMESCO Finland
Procedure duration 0 to 9 minutes
4.4
7.7
19
44
IER04
NOMESCO Finland
Rehabilitative psychiatric group intervention, functional
12.0
7.6
13
11
F22.9
ICD-10 Finland
Persistent delusional disorder, unspecified
12.0
7.6
13
11
N03AX14
ATC
levetiracetam; systemic
3.5
7.6
26
77
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
6.3
7.6
19
31
F10.20
ICD-10 Finland
Alcohol dependence currently independent
4.2
7.6
20
49
R1250
NOMESCO Finland
Evaluation of functional capability
3.9
7.6
22
58
P72
ICPC
Schizophrenia
4.3
7.5
19
45
Z2446
NOMESCO Finland
Social worker
2.3
7.5
59
273
F07.0
ICD-10 Finland
Organic personality disorder
80.8
7.4
8
*
IGV01
NOMESCO Finland
Psychiatric network contact
13.5
7.4
12
9
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
13.5
7.4
12
9
Z75.5
ICD-10 Finland
Holiday relief care
6.9
7.3
17
25
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
9.5
7.3
14
15
F02.04
ICD-10 Finland
Dementia in Pick's disease other additional symptoms of mixed type
+∞
7.3
7
*
F0019, G301,
ICD-10 Finland
+∞
7.3
7
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.9
7.3
21
55
P98
ICPC
Psychosis NOS/other
15.9
7.2
11
7
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.7
7.2
22
60
R4130, ,
SPAT
20.2
7.1
10
5
Z03.2
ICD-10 Finland
Observation for suspected mental and behavioural disorders
8.0
7.1
15
19
34599
ICD-8 Finland
Epilepsy, Other and unspecified
12.2
7.1
12
10
SPAT1294
SPAT
Other function in accordance with health social work nomenclature
3.2
7.1
28
91
F31
ICD-10 Finland
Bipolar affective disorder
8.9
7.1
14
16
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
10.1
7.0
13
13
F01.9
ICD-10 Finland
Vascular dementia, unspecified
3.5
7.0
24
71
N04AA02
ATC
biperiden; systemic
4.0
6.9
19
48
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
8.4
6.8
14
17
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
6.8
6.8
16
24
P76
ICPC
Depressive disorder
2.7
6.8
35
132
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
5.7
6.8
18
32
N03AF02
ATC
oxcarbazepine; oral
3.2
6.8
26
83
F23.99
ICD-10 Finland
Acute and transient psychosis, unspecified UNS
40.4
6.8
8
*
Z02.7
ICD-10 Finland
Issue of medical certificate
2.2
6.8
54
251
79199
ICD-8 Finland
Headache
3.9
6.7
19
49
R32
ICD-10 Finland
Unspecified urinary incontinence
3.1
6.7
28
94
E86
ICD-10 Finland
Volume depletion
3.0
6.6
29
100
P01
ICPC
Feeling anxious/nervous/tense
2.4
6.6
46
201
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
3.6
6.6
21
59
F05.1
ICD-10 Finland
Delirium superimposed on dementia
12.4
6.6
11
9
F06.0
ICD-10 Finland
Organic hallucinosis
12.4
6.6
11
9
R44.3
ICD-10 Finland
Hallucinations, unspecified
8.8
6.6
13
15
S72.0
ICD-10 Finland
Fracture of neck of femur
2.3
6.5
48
216
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
5.8
6.5
17
30
I95.1
ICD-10 Finland
Orthostatic hypotension
2.4
6.4
43
185
R25.1
ICD-10 Finland
Tremor, unspecified
2.8
6.4
30
108
F21, ,
ICPC
6.6
6.4
15
23
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.7
6.3
128
814
F009, G309,
ICD-10 Finland
+∞
6.3
6
*
F020, G310,
ICD-10 Finland
+∞
6.3
6
*
F060, G310,
ICD-10 Finland
+∞
6.3
6
*
F06.33
ICD-10 Finland
Organic mood syndrome
+∞
6.3
6
*
F02.01
ICD-10 Finland
Dementia in Pick's disease has other additional symptoms, mainly paranoidism
+∞
6.3
6
*
N05AF05
ATC
zuclopenthixol; systemic
7.1
6.2
14
20
85190
ICD-8 Finland
Cerebral laceration and contusion, Late effect
26.9
6.2
8
*
F30.9
ICD-10 Finland
Manic episode, unspecified
26.9
6.2
8
*
X59
ICD-10 Finland
Exposure to unspecified factor
1.7
6.2
132
849
N06AX21
ATC
duloxetine; oral
1.9
6.2
79
437
G20
ICD-10 Finland
Parkinson disease
2.6
6.2
36
145
I67.3
ICD-10 Finland
Progressive vascular leukoencephalopathy
3.8
6.1
18
48
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
3.1
6.1
24
78
SPAT1101
SPAT
Orthostatic test
2.3
6.1
45
203
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
6.8
6.1
14
21
N05BE01
ATC
buspirone; oral
3.0
6.0
26
89

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
122
30
47.94
205.61
1.0
1.0
884.32
747.27
ng/l
0.83
95
15
121
30
47.48
203.48
1.0
1.0
277.93
201.00
ng/l
2.83
100
14
114
108
12.17
107.22
1.1
1.3
2.72
60.61
e6/l
0.65
82
85
113
108
12.05
105.63
1.1
1.3
818.23
1198.36
e6/l
0.14
87
88
86
68
14.08
90.21
5.9
4.6
322.18
359.28
umol/l
1.08
74
60
89
100
9.91
73.65
1.1
1.2
—
—
—
0
0
63
45
15.13
69.72
1.3
1.4
—
—
—
0
0
53
47
12.02
51.37
1.1
1.1
—
—
—
0
0
262
1360
2.39
27.07
1.9
1.8
1180.96
1169.49
nmol/l
0.07
211
1019
415
2793
2.03
20.72
2.4
2.1
92.30
94.13
pmol/l
0.35
234
1416
266
1663
1.91
15.25
1.7
1.6
20.27
20.59
nmol/l
0.14
249
1381
89
1794
0.43
12.87
2.5
3.3
—
—
—
0
0
288
1969
1.73
11.62
3.5
4.0
7.40
7.40
ph
0.03
31
381
208
1295
1.82
11.57
2.9
3.3
2.44
2.46
mmol/l
2.09
169
1135
429
3312
1.65
10.60
5.8
6.9
1.22
1.21
mmol/l
3.67
374
2813
401
3046
1.65
10.55
5.4
6.1
1.22
1.21
mmol/l
2.06
371
2762
310
2207
1.67
10.51
2.7
3.6
2.34
2.35
mmol/l
0.79
266
1916
46
167
2.86
9.55
1.3
1.3
—
—
—
0
0
375
2877
1.58
8.94
3.8
4.9
35.43
34.78
g/l
1.43
342
2668
281
2020
1.61
8.80
2.7
2.2
798.95
243.80
u/l
0.54
267
1895
286
2137
1.53
7.25
3.8
3.4
—
—
—
0
0
13
13
10.15
7.05
16.8
12.4
1462.77
1615.85
nmol/l
0.24
13
13
192
1325
1.59
6.87
4.0
4.2
374.58
296.54
ng/l
0.20
169
1122
174
2452
0.63
6.76
1.9
2.2
—
—
—
0
0
101
591
1.81
6.66
2.6
2.4
31.70
34.26
u/l
0.31
86
501
202
1438
1.54
6.24
4.4
3.9
—
—
—
0
0
259
1952
1.49
6.08
4.3
4.4
—
—
—
0
0
16
30
5.42
5.87
1.0
1.0
120.38
142.51
nmol/l
0.74
16
30
496
5612
0.69
5.84
3.5
4.3
1.31
1.28
mmol/l
0.36
430
4998
518
5800
0.69
5.59
3.9
4.8
1.44
1.45
mmol/l
0.37
463
5211
185
1322
1.52
5.55
5.2
4.5
1.01
1.02
kg/l
1.19
29
206
240
1822
1.46
5.31
3.5
3.3
—
—
—
0
0
169
1202
1.52
5.15
3.0
2.9
1.76
1.12
e6/l
1.01
81
714
217
1629
1.46
5.05
4.0
4.0
89.77
85.45
%
1.76
208
1595
161
1142
1.52
4.96
3.0
3.1
4.43
2.18
e6/l
0.69
71
658
544
5994
0.70
4.84
4.8
5.5
2.67
2.61
mmol/l
0.59
489
5398
164
2209
0.67
4.75
2.9
3.8
3.70
8.95
mg/mmol
5.21
101
1402
529
5850
0.71
4.73
4.0
4.8
4.56
4.51
mmol/l
0.50
472
5301
155
2107
0.67
4.70
3.1
4.2
—
—
—
0
0
510
5672
0.71
4.69
5.6
6.5
39.40
40.86
mmol/mol
3.53
475
5158
157
2085
0.69
4.11
2.7
3.3
438.62
246.38
mg/l
0.19
102
1348
8
10
8.07
4.06
1.4
2.0
29.20
15.17
umol/l
—
8
10
241
1917
1.37
3.89
3.5
3.4
0.33
0.59
e6/l
1.86
174
1477
161
2108
0.70
3.85
2.5
3.2
7.44
7.16
mmol/l
0.37
142
1732
45
784
0.55
3.83
3.3
4.2
16.07
33.24
ug/l
0.59
40
657
50
281
1.83
3.81
2.3
3.2
4.17
4.47
pmol/l
1.09
38
247
11
24
4.63
3.75
1.8
1.4
—
—
—
0
0
39
205
1.95
3.64
2.7
3.5
—
—
—
0
0
30
143
2.14
3.63
2.4
2.9
34.39
33.43
umol/l
0.07
23
127
11
25
4.45
3.63
1.1
1.2
—
—
—
0
0
189
1462
1.39
3.59
1.7
1.8
462.20
13442215.84
pmol/l
1.06
155
1168
25
504
0.48
3.37
2.5
4.1
0.29
0.11
%
—
7
163
145
1084
1.41
3.35
1.5
1.9
29.81
29.84
s
0.02
138
1052
284
2361
1.32
3.32
4.2
4.0
80.63
123.63
e6/l
0.60
194
1746
14
48
2.95
3.31
1.4
1.1
—
—
—
0
0
33
603
0.53
3.31
1.2
1.4
—
—
—
0
0
188
2351
0.74
3.29
2.7
3.1
766.67
1786.72
ng/l
11.68
156
2042
255
2094
1.32
3.24
3.5
3.5
71.37
102.49
e6/l
0.35
184
1640
14
49
2.89
3.20
1.4
1.1
—
—
—
0
0
24
480
0.48
3.18
3.5
4.1
0.17
0.71
%
—
6
140
58
894
0.62
3.09
1.2
1.3
4.65
13.43
u/ml
1.40
17
308
13
41
3.21
3.06
1.2
1.1
—
—
—
0
0
283
2375
1.30
3.03
4.0
3.8
5.81
5.89
ph
—
8
126
53
829
0.61
3.01
1.2
1.3
—
—
—
0
0
14
51
2.78
3.00
1.4
1.1
—
—
—
0
0
14
51
2.78
3.00
1.4
1.1
—
—
—
0
0
14
51
2.78
3.00
1.4
1.1
—
—
—
0
0
5
5
10.05
2.98
1.0
1.0
9.25
8.23
mg/g
—
5
5
25
480
0.51
2.95
3.4
3.9
1.44
0.58
%
—
9
165
63
935
0.65
2.84
1.2
1.3
32.95
37.03
iu/ml
0.08
19
305
45
720
0.60
2.81
1.0
1.3
—
—
—
0
0
120
1575
0.72
2.81
3.9
3.9
—
—
—
0
0
77
530
1.50
2.74
3.1
3.9
77.03
90.54
ng/l
0.95
62
467
255
3000
0.78
2.74
2.4
2.7
—
—
—
0
0
31
537
0.56
2.63
3.2
4.0
1.85
0.93
%
1.08
13
196
84
595
1.46
2.61
4.5
8.2
—
—
—
0
0
288
2460
1.27
2.61
2.2
2.2
77.03
79.21
nmol/l
0.61
257
2139
549
5880
0.78
2.55
4.7
5.1
5.99
6.07
mmol/l
0.72
508
5241
512
4684
1.27
2.55
27.2
22.3
331.81
331.37
g/l
0.45
498
4646
10
34
2.97
2.28
1.8
1.2
—
—
—
0
0
484
4436
1.24
2.20
4.4
3.9
14.70
15.04
pmol/l
2.01
448
3917
8
196
0.40
2.20
1.1
1.5
—
—
—
0
0
11
252
0.43
2.16
1.2
1.4
—
—
—
0
0
25
138
1.84
2.11
1.1
1.2
—
—
—
0
0
72
518
1.43
2.09
1.7
2.0
386.95
372.92
nmol/l
0.21
61
472
13
56
2.34
2.05
1.3
1.2
252.38
341.30
nmol/l
1.10
13
47
119
1489
0.76
1.99
1.3
1.3
—
—
—
0
0
140
1713
0.78
1.97
2.2
2.8
6432.09
8228.24
umol/l
0.16
107
1455
88
664
1.37
1.96
2.4
3.0
121.86
258.55
ng/l
6.71
83
609
232
2678
0.81
1.95
7.9
10.0
0.00
0.00
e9/l
0.49
170
2185
15
293
0.50
1.93
3.6
3.5
185.14
13955.77
u/ml
—
7
247
86
649
1.37
1.91
2.8
3.7
2.73
1.99
mmol/l
1.12
74
534
22
376
0.57
1.84
2.1
4.0
—
—
—
0
0
170
1418
1.25
1.82
2.6
3.2
539.13
540.90
mosm/kgh2o
0.04
144
1221
7
168
0.41
1.80
1.7
1.7
—
—
—
0
0
183
1542
1.24
1.79
5.7
6.8
—
—
—
0
0
35
530
0.64
1.79
4.9
4.2
—
—
—
0
0
10
216
0.46
1.73
2.2
5.1
—
—
—
0
0
29
179
1.64
1.72
1.3
1.2
—
—
—
0
0
11
228
0.48
1.71
1.1
1.3
—
—
—
0
0
121
1481
0.78
1.70
2.4
3.2
1.00
0.81
ug/l
0.40
93
1025
174
1470
1.24
1.66
2.6
2.7
6.72
4.71
e6/l
0.56
157
1330
66
874
0.73
1.64
1.4
1.2
—
—
—
0
0
130
1068
1.26
1.59
2.6
3.3
0.84
0.82
mmol/l
1.19
118
1004
16
285
0.55
1.57
1.1
1.3
—
—
—
0
0
39
561
0.68
1.57
2.8
3.7
1.23
1.22
mmol/l
0.58
34
486
18
309
0.57
1.56
1.7
1.3
—
—
—
0
0
32
476
0.66
1.53
1.8
1.5
—
—
—
0
0
5
125
0.40
1.51
1.2
1.4
1.94
0.86
nmol/l
—
5
100
40
277
1.47
1.48
9.7
4.3
—
—
—
0
0
29
433
0.66
1.42
4.7
2.9
—
—
—
0
0
460
4292
1.17
1.41
5.1
4.6
—
—
—
0
0
0
37
0.00
1.34
0.0
1.9
—
0.99
—
0
32
220
2472
0.85
1.30
2.9
2.8
127.68
154.75
ug/l
1.29
202
2217
104
854
1.25
1.30
6.3
7.0
1.16
1.17
mmol/l
0.01
80
681
23
350
0.65
1.26
3.5
4.0
—
—
—
0
0
35
490
0.70
1.26
1.5
1.5
—
—
—
0
0
12
63
1.92
1.23
1.1
1.3
—
—
nmol/l
—
0
0
79
976
0.79
1.22
2.2
2.5
21.98
22.08
%
0.02
66
842
145
1680
0.83
1.21
1.7
1.7
1.42
1.34
mmol/l
0.54
127
1361
6
127
0.47
1.17
1.7
1.8
38.50
43.13
nmol/l
—
6
119
6
127
0.47
1.17
1.3
1.2
7.84
35.98
u/l
—
6
111
0
33
0.00
1.16
0.0
1.3
—
61.09
—
0
23
57
729
0.76
1.16
1.1
1.3
630.00
514.32
titre
—
8
169
82
1002
0.80
1.16
1.9
2.0
—
—
—
0
0
102
848
1.23
1.15
6.4
7.1
5.09
5.11
kpa
0.07
97
813
102
849
1.23
1.14
6.4
7.0
11.74
11.86
kpa
0.08
97
814
5
114
0.44
1.13
1.4
2.6
—
—
—
0
0
7
138
0.50
1.10
1.0
1.3
—
—
—
0
0
60
756
0.78
1.10
1.2
1.4
—
—
—
0
0
608
6292
0.85
1.09
10.2
11.3
23.99
24.94
u/l
0.85
580
6029
78
635
1.25
1.07
3.2
2.6
7.65
6.74
ug/l
0.12
64
553
75
610
1.25
1.04
5.3
7.0
1.39
1.42
mmol/l
0.12
70
598
8
147
0.54
1.04
1.9
3.5
789.29
2492.27
u/ml
—
8
139
5
106
0.47
1.01
2.8
2.7
—
—
—
0
0
10
176
0.56
1.01
1.1
1.2
—
—
—
0
0
16
249
0.64
1.00
2.8
3.1
0.10
0.30
g/l
—
7
100
323
2989
1.14
1.00
4.4
4.0
0.08
0.00
estimate
0.48
37
609
11
188
0.58
1.00
1.0
1.5
1.24
1.17
g/l
0.32
11
179
6
117
0.51
0.94
1.3
1.6
—
—
—
0
0
381
3575
1.13
0.93
3.8
3.2
47.44
56.03
u/l
0.98
356
3264
408
3846
1.13
0.92
5.4
4.9
6.86
6.79
mmol/l
0.28
378
3640
627
6451
0.86
0.91
27.5
24.6
242.80
241.67
e9/l
0.17
602
6255
36
472
0.75
0.91
3.4
3.9
7.40
7.41
ph
—
6
60
564
5427
1.14
0.90
5.6
4.7
2.10
2.04
mu/l
0.16
518
4815
63
513
1.25
0.89
5.7
4.3
—
—
—
0
0
11
181
0.60
0.88
1.0
1.5
0.26
0.23
g/l
0.59
11
172
6
30
2.01
0.87
1.0
1.5
154.17
172.36
mmol/24h
—
6
30
87
1022
0.83
0.87
2.2
2.5
2.25
2.28
g/l
0.15
73
954
95
1106
0.84
0.86
2.3
2.5
12.20
12.33
umol/l
0.06
83
1039
628
6453
0.87
0.85
27.5
24.6
4.35
4.42
e12/l
2.58
600
6235
628
6453
0.87
0.85
27.4
24.5
91.64
91.68
fl
0.08
611
6328
628
6453
0.87
0.85
27.5
24.6
6.96
6.79
e9/l
1.02
601
6233
628
6453
0.87
0.85
27.6
24.7
131.60
133.48
g/l
2.46
611
6328
69
571
1.23
0.85
4.0
3.4
—
—
—
0
0
11
179
0.61
0.85
2.1
2.4
—
—
—
0
0
628
6452
0.87
0.85
27.3
24.5
30.48
30.43
pg
0.33
611
6327
628
6449
0.87
0.82
27.5
24.8
39.23
39.52
%
0.55
561
5970
212
1934
1.13
0.81
2.9
3.1
35.87
32.85
u/l
0.28
196
1841
10
58
1.73
0.80
1.1
1.2
29.80
33.92
mmol/l
—
5
53
0
25
0.00
0.79
0.0
1.1
—
26.07
—
0
20
0
25
0.00
0.79
0.0
2.0
—
—
—
0
0
0
25
0.00
0.79
0.0
1.4
—
—
—
0
0
508
4878
1.12
0.77
6.3
7.7
78.88
80.66
u/l
0.32
476
4550
0
27
0.00
0.77
0.0
2.2
—
61009.94
—
0
18
0
28
0.00
0.76
0.0
3.5
—
—
—
0
0
0
28
0.00
0.76
0.0
1.3
—
1.43
—
0
7
0
28
0.00
0.76
0.0
2.1
—
415.87
—
0
23
0
28
0.00
0.76
0.0
1.3
—
1.53
—
0
21
6
110
0.54
0.72
1.0
1.4
28.67
29.85
g/l
—
6
100
31
398
0.77
0.71
2.5
2.9
0.70
0.32
e6/l
0.30
31
385
7
118
0.59
0.68
1.0
1.2
—
—
—
0
0
146
1613
0.88
0.67
2.2
2.4
—
—
—
0
0
5
29
1.73
0.64
4.4
5.9
—
—
—
0
0
34
422
0.80
0.61
1.9
2.2
11.44
12.59
nmol/l
0.33
24
367
316
2990
1.10
0.60
5.6
5.4
0.00
0.00
estimate
-0.00
33
560
96
849
1.15
0.60
1.5
2.5
1.84
1.78
%
0.23
84
760
0
20
0.00
0.60
0.0
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
5.0
—
49.42
—
0
20
0
21
0.00
0.60
0.0
1.1
—
16.06
—
0
14
0
23
0.00
0.58
0.0
1.3
—
35.73
—
0
15
0
23
0.00
0.58
0.0
2.4
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
22
167
1.33
0.57
1.8
2.4
—
—
—
0
0
45
376
1.21
0.55
1.2
1.2
—
—
—
0
0
21
273
0.76
0.55
1.7
1.9
—
—
—
0
0
46
545
0.83
0.55
1.6
1.5
—
—
—
0
0
8
125
0.64
0.55
1.5
1.5
—
—
—
0
0
319
3033
1.09
0.54
4.4
4.0
0.00
0.01
estimate
0.50
32
551
23
178
1.30
0.53
3.7
4.2
7.42
7.42
ph
0.18
17
161
25
197
1.28
0.51
1.4
2.1
22.05
21.63
s
0.17
20
184
32
389
0.82
0.50
3.1
2.9
7.02
5.43
e9/l
0.26
24
296
6
41
1.47
0.50
4.8
3.8
—
—
—
0
0
14
190
0.73
0.50
1.4
2.4
54.81
85.33
ug/min
—
7
110
10
67
1.50
0.50
1.2
1.2
—
—
—
0
0
10
67
1.50
0.50
3.7
3.5
—
—
—
0
0
92
1023
0.89
0.49
1.3
1.5
2.06
2.63
g/l
3.67
45
603
32
262
1.23
0.49
8.4
3.6
1.58
1.38
mmol/l
0.61
32
255
64
560
1.16
0.48
1.2
1.5
—
—
—
0
0
7
109
0.64
0.48
1.3
1.5
—
—
—
0
0
29
235
1.24
0.48
1.7
2.8
39.99
37.09
g/l
2.26
20
206
7
49
1.43
0.46
4.6
2.5
—
—
—
0
0
11
153
0.71
0.46
3.0
3.7
22.87
26.15
mg/l
—
6
99
273
2865
0.93
0.44
4.9
6.0
8.54
8.91
%
1.26
249
2654
20
157
1.28
0.43
2.0
2.4
131.15
126.46
g/l
0.26
13
117
277
2903
0.93
0.43
4.7
5.9
25.36
26.35
%
0.79
256
2690
9
130
0.69
0.43
2.1
1.7
—
—
—
0
0
6
94
0.64
0.42
2.7
1.4
—
—
—
0
0
19
149
1.28
0.42
3.1
3.8
—
—
—
0
0
183
1718
1.08
0.42
2.5
2.2
2.99
3.13
mg/l
0.22
162
1437
242
2544
0.93
0.41
4.5
5.5
2.36
3.56
ug/l
1.51
202
2250
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.6
—
—
—
0
0
0
16
0.00
0.41
0.0
1.5
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
—
—
0
0
0
18
0.00
0.40
0.0
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
5.47
—
0
12
273
2852
0.93
0.39
4.6
5.7
2.70
2.88
%
0.65
251
2640
12
89
1.35
0.38
1.7
1.2
—
—
—
0
0
8
111
0.72
0.37
1.1
2.1
—
—
—
0
0
8
114
0.70
0.37
1.9
1.7
—
—
—
0
0
266
2777
0.94
0.37
4.6
5.7
0.64
0.65
%
0.03
244
2572
45
396
1.14
0.34
4.2
9.2
—
—
—
0
0
31
361
0.85
0.34
1.3
1.3
—
—
—
0
0
6
46
1.31
0.33
1.0
1.2
—
—
—
0
0
6
90
0.66
0.33
2.3
6.0
11.77
12.18
mg/l
—
6
83
6
90
0.66
0.33
1.3
1.9
89.95
89.27
%
—
6
90
275
2856
0.94
0.32
4.7
5.6
59.97
58.18
%
1.61
254
2653
53
590
0.89
0.32
1.7
2.1
167.70
147.65
ug/g
0.21
41
469
602
5926
1.07
0.31
19.0
16.7
28.59
26.18
mg/l
0.94
497
4797
622
6303
0.94
0.29
23.2
20.0
3.95
4.00
mmol/l
5.27
601
6119
8
64
1.25
0.27
1.0
1.3
—
—
—
0
0
202
2104
0.95
0.26
2.4
2.6
—
—
—
0
0
352
3427
1.05
0.26
4.6
6.3
11.93
11.81
umol/l
0.05
327
3260
5
74
0.67
0.26
1.0
2.6
—
1.65
—
0
37
5
74
0.67
0.26
1.0
3.2
8.48
5.60
nmol/l
—
5
74
5
74
0.67
0.26
1.2
2.0
—
—
—
0
0
29
330
0.87
0.25
2.7
2.9
—
—
—
0
0
600
6078
0.95
0.25
16.6
16.0
—
—
—
0
0
6
82
0.73
0.24
1.0
1.0
—
—
—
0
0
5
38
1.32
0.23
1.8
1.7
—
—
—
0
0
10
125
0.80
0.23
1.0
1.1
—
—
—
0
0
7
93
0.75
0.22
1.0
1.5
—
—
—
0
0
622
6287
0.95
0.22
23.4
19.9
139.74
139.61
mmol/l
0.57
601
6109
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
37.27
—
0
11
0
11
0.00
0.21
0.0
1.1
—
0.25
—
0
5
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.6
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
5.6
—
—
—
0
0
0
13
0.00
0.21
0.0
2.9
—
5999.62
—
0
13
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.6
—
5.43
—
0
7
16
187
0.85
0.20
1.9
3.9
—
—
—
0
0
12
144
0.83
0.20
2.5
2.7
—
—
—
0
0
36
327
1.11
0.19
1.4
1.3
—
—
—
0
0
19
165
1.16
0.19
1.1
1.1
—
—
—
0
0
7
62
1.13
0.17
1.9
1.5
10.41
10.46
%
—
7
62
10
82
1.22
0.17
2.0
1.6
408.70
291.34
mu/l
—
10
76
74
701
1.06
0.16
3.6
4.5
—
—
—
0
0
197
2026
0.96
0.16
2.6
2.5
49.79
100.10
u/l
0.68
184
1857
23
255
0.90
0.15
1.9
3.7
58.78
87.51
mg/l
0.50
17
208
23
255
0.90
0.15
1.9
3.7
27.58
50.95
mg/l
1.16
17
210
295
3009
0.97
0.15
4.6
5.4
0.59
0.61
e9/l
0.49
235
2565
277
2828
0.97
0.15
4.7
6.1
—
—
—
0
0
131
1356
0.96
0.15
1.7
1.6
1.41
1.34
mg/l
0.08
101
1069
296
3017
0.97
0.14
4.6
5.4
0.04
0.04
e9/l
0.08
237
2576
30
275
1.09
0.14
2.0
2.7
10.21
10.45
g/l
0.11
21
245
50
529
0.94
0.13
1.8
2.5
—
—
—
0
0
36
336
1.07
0.12
3.7
3.4
25.79
25.10
mmol/l
0.57
36
327
331
3359
0.97
0.12
11.0
17.8
1.21
1.33
inr
1.31
62
964
21
192
1.10
0.11
16.9
12.0
—
—
—
0
0
348
3525
0.98
0.10
7.7
8.8
4.61
4.18
e9/l
1.59
293
3061
22
202
1.09
0.10
1.2
1.4
251.07
277.38
ug/g
0.35
15
118
18
196
0.92
0.09
1.7
1.6
—
—
—
0
0
5
63
0.79
0.08
1.0
1.0
—
—
—
0
0
7
64
1.09
0.08
1.0
1.2
—
—
—
0
0
7
67
1.05
0.08
2.3
2.2
—
—
—
0
0
303
3064
0.98
0.07
4.8
5.5
1.82
1.89
e9/l
0.23
250
2677
451
4544
0.98
0.07
3.4
4.2
12.91
14.17
mm/h
1.02
410
4148
168
1651
1.02
0.07
5.6
4.3
0.00
0.01
estimate
0.50
29
538
309
3123
0.98
0.07
5.2
5.6
0.20
0.20
e9/l
0.13
255
2711
111
1133
0.98
0.06
1.3
1.2
1.38
1.50
u/ml
0.05
22
295
9
101
0.89
0.06
1.1
2.0
31.33
32.19
pg
—
9
101
48
496
0.97
0.05
1.4
1.5
—
—
—
0
0
30
287
1.05
0.05
1.0
1.1
55.67
124.96
iu/ml
—
8
103
18
169
1.07
0.05
1.0
1.0
—
—
—
0
0
267
2647
1.01
0.05
4.4
4.1
26.61
43.31
ng/l
4.63
203
2052
73
746
0.98
0.04
1.8
1.7
—
—
—
0
0
16
150
1.07
0.04
3.3
4.5
2.85
2.67
mmol/l
0.09
11
104
74
727
1.02
0.03
2.5
2.9
9.85
9.08
umol/l
0.12
61
641
61
619
0.98
0.02
1.9
2.9
66.59
65.93
g/l
0.31
49
562
47
462
1.02
0.01
1.5
1.5
—
—
—
0
0
63
638
0.99
0.01
1.5
2.6
73.87
68.63
e9/l
0.44
43
508
501
5001
1.00
0.01
23.3
19.9
14.73
15.47
%
2.64
490
4917
442
4426
1.00
0.00
4.1
4.3
—
—
—
0
0
13
135
0.96
0.00
1.5
1.9
51.23
60.65
%
0.71
13
135
38
378
1.01
0.00
2.2
2.6
—
—
—
0
0
89
892
1.00
0.00
4.3
5.6
1.00
1.04
mmol/l
0.81
79
826
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
7
71
0.99
-0.00
1.7
1.3
39.06
30.10
iu/l
—
7
62
0
8
0.00
-0.00
0.0
2.1
—
—
—
0
0
8
81
0.99
-0.00
1.3
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
11
110
1.00
-0.00
1.1
1.5
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
2.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
3.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
6.2
—
0.34
—
0
5
64
640
1.00
-0.00
4.4
7.2
10.83
10.93
mmol/l
0.03
55
608
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
79
1.01
-0.00
1.1
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_ATROPHCIRCUM and mortality.

Females

Parameter HR [95% CI] p-value
G6_ATROPHCIRCUM 3.807 [3.24, 4.47] < 0.001
Birth year 0.996 [0.99, 1.0] 0.335

During the follow-up period (1.1.1998 — 31.12.2019), 1496 out of 2867 females with G6_ATROPHCIRCUM died.

Males

Parameter HR [95% CI] p-value
G6_ATROPHCIRCUM 3.818 [3.16, 4.61] < 0.001
Birth year 0.991 [0.98, 1.0] 0.052

During the follow-up period (1.1.1998 — 31.12.2019), 1262 out of 2230 males with G6_ATROPHCIRCUM died.

Mortality risk

Mortality risk for people of age

years, who have G6_ATROPHCIRCUM.

N-year risk Females Males
1 0.352% 0.706%
5 2.162% 4.74%
10 5.576% 11.668%
15 10.637% 21.832%
20 18.658% 34.354%

Relationships between endpoints

Index endpoint: G6_ATROPHCIRCUM – Circumscribed brain atrophy

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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