Communicating hydrocephalus

G6_HCCOMM

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 G91.0
  • Hospital discharge: ICD-9 3313
  • Cause of death: ICD-10 G91.0
  • Cause of death: ICD-9 3313

2 out of 7 registries used, show all original rules.

769

4. Check minimum number of events

None

769

5. Include endpoints

None

769

6. Filter based on genotype QC (FinnGen only)

769

Control definitions (FinnGen only)

Control exclude
G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
G91
Name in latin
Hydrocephalia communicans

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6750 3351 3305
Only index persons 4677 2460 2217
Unadjusted period prevalence (%)
Whole population 0.09 0.10 0.09
Only index persons 0.09 0.09 0.08
Median age at first event (years)
Whole population 59.21 61.43 56.68
Only index persons 55.27 58.24 51.98

-FinnGen-

Key figures

All Female Male
Number of individuals 769 403 366
Unadjusted period prevalence (%) 0.15 0.14 0.16
Median age at first event (years) 60.46 59.84 61.15

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
696
Matched controls
6960
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
1904.2
323.0
366
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
323.0
626
*
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
273.5
244
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
+∞
209.2
190
*
AAF00
NOMESCO Finland
Ventriculostomy
502.2
191.9
183
5
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
163.1
150
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
129.0
159.5
167
17
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
149.5
138
*
AA1AD
NOMESCO Finland
CT of head and brain
7.6
127.4
404
1070
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
61.7
116.4
135
27
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
16.6
108.8
183
146
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
101.6
95
*
AA1AA
NOMESCO Finland
Head X-ray examination
116.0
101.3
108
11
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
98.3
92
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
1003.6
92.0
88
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
977.5
89.8
86
*
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
77.6
73
*
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
52.9
70.5
84
18
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
677.2
63.9
62
*
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
52.4
62.9
75
16
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
+∞
58.1
55
*
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
56.9
57.1
67
13
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
9.1
54.8
122
159
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
81.7
53.9
60
8
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
23.9
50.9
73
34
2132
FHL
Ventricular operators sunt
274.6
50.8
51
*
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
109.9
47.5
51
5
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
6.6
47.0
131
237
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
35.0
44.9
58
18
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
43.2
41
*
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
49.8
42.6
51
11
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
6.1
42.1
124
239
R51.80
ICD-10 Finland
Headache
4.1
37.0
164
487
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
3.6
36.9
195
673
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.7
36.7
187
626
XA800
NOMESCO Finland
Neuropsychological investigation
8.1
36.2
85
118
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.5
36.1
200
713
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
9.8
36.0
75
85
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
58.9
33.6
39
7
N03AX14
ATC
levetiracetam; systemic
10.2
33.1
67
72
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
51.5
32.8
39
8
K90
ICPC
Stroke/cerebrovascular accident
8.9
31.1
68
84
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.6
30.8
58
54
N03AG01
ATC
valproic acid; systemic, rectal
6.0
30.5
89
167
N03AB02
ATC
phenytoin; systemic
18.8
30.0
46
26
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
12.6
29.9
54
46
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
28.2
29.6
40
15
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.2
29.3
56
54
K91
ICPC
Cerebrovascular disease
18.0
28.3
44
26
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
11.2
28.2
54
52
G40.9
ICD-10 Finland
Epilepsy, unspecified
7.4
28.1
69
102
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
12.5
25.6
46
39
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
25.2
24
*
2133
FHL
Suntin revisio
258.9
24.8
25
*
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
93.5
24.8
27
*
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
24.1
23
*
TAB00
NOMESCO Finland
Lumbar puncture
5.6
23.1
70
137
N18
ICPC
Paralysis/weakness
10.2
22.6
45
47
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.7
21.6
102
310
N03AF02
ATC
oxcarbazepine; oral
6.8
21.1
54
85
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
15.5
20.9
34
23
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.8
20.8
95
281
4300A
ICD-9 Finland
Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOID. POST ANEURYSMA SACCULARE]
33.7
20.3
26
8
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
59.3
20.0
23
*
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
59.3
20.0
23
*
N03AF01
ATC
carbamazepine; oral, rectal
4.6
19.8
72
172
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.2
19.8
263
1490
ZXA00
NOMESCO Finland
Right side
2.3
19.7
234
1256
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
20.1
19.6
29
15
R4150
NOMESCO Finland
Neuropsychological rehabilitation
32.3
19.4
25
8
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
14.5
19.2
32
23
SPAT1216
SPAT
Assessment of functional ability
2.6
19.2
159
705
SPAT1229
SPAT
Assessment of need for aid
3.5
19.1
96
306
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.8
19.1
86
251
G91
ICD-10 Finland
Hydrocephalus
+∞
18.8
18
*
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
18.8
18
*
H47.2
ICD-10 Finland
Optic atrophy
28.7
18.8
25
9
2161
FHL
Neck ligation, big brain
28.7
18.8
25
9
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.7
18.6
65
149
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.7
18.2
84
250
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
6.9
18.0
45
69
R42
ICD-10 Finland
Dizziness and giddiness
2.3
18.0
194
989
A28
ICPC
Limited function/disability NOS
2.5
17.8
155
706
N28
ICPC
Limited function/disability (N)
9.6
17.3
35
38
L28
ICPC
Limited function/disability (L)
2.5
17.2
155
717
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
3.4
17.2
88
285
A06AD11
ATC
lactulose; oral
2.5
16.7
150
690
-
ICD-10 Finland
NA
7.3
16.6
40
58
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
6.4
16.6
44
73
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
174.0
16.6
17
*
H53.4
ICD-10 Finland
Visual field defects
8.1
16.5
37
48
183
Kela drug reimbursment
Lamotrigin and topiramate
14.7
16.4
27
19
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
41.1
16.4
20
5
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
5.2
16.2
51
105
XCK00
NOMESCO Finland
Perimetry
3.4
16.0
81
260
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
61.5
15.8
18
*
2130
FHL
Ventricular atrial shunt
+∞
15.7
15
*
2124
FHL
Intracranial pressure measurement, intraventricular
+∞
15.7
15
*
N06AB04
ATC
citalopram; systemic
2.2
15.5
177
917
G44.2
ICD-10 Finland
Tension-type headache
2.9
15.5
101
386
R53
ICD-10 Finland
Malaise and fatigue
2.3
15.5
173
889
N05BA09
ATC
clobazam; oral
20.6
15.2
22
11
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.9
15.1
96
361
R1250
NOMESCO Finland
Evaluation of functional capability
7.9
15.1
34
45
N29
ICPC
Neurological sympt/complt other
7.5
14.9
35
49
N05AH04
ATC
quetiapine; oral
2.5
14.8
124
547
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
12.2
14.7
26
22
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.1
14.6
84
295
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
10.4
14.6
28
28
P20
ICPC
Memory disturbance
2.5
14.3
119
525
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.3
14.3
73
236
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.9
14.1
93
357
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
7.3
14.0
33
47
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
18.0
13.9
21
12
WX408
NOMESCO Finland
General anesthesy, balanced
2.0
13.9
209
1211
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
20.5
13.8
20
10
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.9
13.8
31
41
AAD05
NOMESCO Finland
Evacuation of acute subdural haematoma
34.8
13.6
17
5
M03BX01
ATC
baclofen; systemic
9.3
13.3
27
30
R4120
NOMESCO Finland
Occupational therapy
3.4
13.3
65
203
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
12.7
135
671
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.8
12.7
84
321
S06.0
ICD-10 Finland
Concussion
2.6
12.6
95
395
N99
ICPC
Neurological disease other
11.3
12.6
23
21
G81.1
ICD-10 Finland
Spastic hemiplegia
+∞
12.5
12
*
2139
FHL
Other measure in this category
+∞
12.5
12
*
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
132.3
12.5
13
*
N03AX09
ATC
lamotrigine; oral
4.5
12.3
43
100
F03
ICD-10 Finland
Unspecified dementia
3.3
11.8
60
194
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
30.6
11.7
15
5
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.3
11.7
115
551
T90.5
ICD-10 Finland
Sequelae of intracranial injury
10.3
11.6
22
22
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.0
11.6
67
237
I60.5
ICD-10 Finland
Subarachnoid haemorrhage from vertebral artery
+∞
11.5
11
*
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
11.5
11
*
AAK00
NOMESCO Finland
Cranioplasty
121.9
11.5
12
*
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.3
11.3
41
99
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
13.0
11.2
19
15
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
9.4
11.1
22
24
I61.1
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, cortical
14.2
11.0
18
13
G41.9
ICD-10 Finland
Status epilepticus, unspecified
14.2
11.0
18
13
G04BD07
ATC
tolterodine; oral
3.0
11.0
63
221
R51
ICD-10 Finland
Headache
3.9
11.0
45
122
G03.9
ICD-10 Finland
Meningitis, unspecified
44.0
10.9
13
*
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
44.0
10.9
13
*
I60.8
ICD-10 Finland
Other subarachnoid haemorrhage
44.0
10.9
13
*
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
10.9
142
766
N02BE01
ATC
paracetamol; systemic, rectal
1.9
10.8
572
4907
SPAT1234
SPAT
Support of social functional capacity
3.2
10.8
56
184
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.1
10.7
129
675
N05AX08
ATC
risperidone; systemic
2.7
10.6
74
294
AA1BD
NOMESCO Finland
Extensive CT of head and brain
5.0
10.6
33
68
AAK80
NOMESCO Finland
Partial excision of skull cap
+∞
10.4
10
*
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
10.4
10
*
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
23.8
10.3
14
6
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.0
10.2
58
203
G40.2
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
11.5
10.1
18
16
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.5
10.0
82
357
ZXC86
NOMESCO Finland
Use of endoscopic device
17.0
9.9
15
9
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.4
9.7
46
142
N05BA01
ATC
diazepam; systemic, rectal
2.2
9.6
107
538
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.9
9.6
38
101
2127
FHL
Ventriculostomy
101.4
9.4
10
*
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
30.5
9.4
12
*
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
9.4
9
*
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.2
9.3
97
473
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
5.6
9.3
26
48
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
6.0
9.1
24
41
N03AX18
ATC
lacosamide; systemic
11.7
9.1
16
14
I69.2
ICD-10 Finland
Sequelae of other nontraumatic intracranial haemorrhage
37.2
9.0
11
*
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.6
9.0
40
117
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.9
9.0
24
42
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
24.4
8.9
12
5
AA5PD
NOMESCO Finland
CT examination of brain pefusion
10.9
8.8
16
15
H47.1
ICD-10 Finland
Papilloedema, unspecified
16.5
8.6
13
8
R1100
NOMESCO Finland
General evaluation of the need for rehabilitation
6.5
8.5
21
33
WX704
NOMESCO Finland
Intubation
2.8
8.5
55
210
2152
FHL
Extraction, big brain
91.1
8.4
9
*
N06AB10
ATC
escitalopram; oral
2.0
8.4
122
682
Z75.5
ICD-10 Finland
Holiday relief care
8.0
8.4
18
23
34793
ICD-8 Finland
Other disease of brain, Hydrocephalus acquisitus NUD
+∞
8.3
8
*
AAB30
NOMESCO Finland
Evacuation of spontaneous intracranial haematoma
+∞
8.3
8
*
AAK85
NOMESCO Finland
Replantation of previously excised part of skull cap
+∞
8.3
8
*
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
+∞
8.3
8
*
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
8.3
8
*
Z03
ICPC
Housing/neighbourhood problem
10.9
8.3
15
14
WYA20
NOMESCO Finland
Home visit
5.5
8.2
23
43
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
11.9
8.1
14
12
AA9CW
NOMESCO Finland
NA
33.8
8.1
10
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
10.2
8.1
15
15
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
10.2
8.1
15
15
RT150
NOMESCO Finland
NA
22.3
8.0
11
5
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.2
8.0
79
377
N05CD08
ATC
midazolam; nasal, systemic
4.3
8.0
28
67
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
13.2
7.9
13
10
4380A
ICD-9 Finland
Late effects of cerebrovascular disease[SEQUELAE MORBI CEREBROVASCULARIS]
11.0
7.8
14
13
U04
ICPC
Incontinence urine
2.8
7.8
49
184
SPAT1053
SPAT
Memory test
1.9
7.7
122
705
R11
ICD-10 Finland
Nausea and vomiting
2.3
7.6
70
323
G40.10
ICD-10 Finland
Simple partial seizures
8.2
7.6
16
20
RS313
NOMESCO Finland
NA
25.3
7.6
10
*
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
6.3
7.6
19
31
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
7.6
112
631
N05AH03
ATC
olanzapine; systemic
3.2
7.5
38
124
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
7.2
7.5
17
24
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
3.2
7.5
38
125
R5599
NOMESCO Finland
Other rehabilitation service
4.0
7.4
28
72
I60
ICD-10 Finland
Subarachnoid haemorrhage
80.9
7.4
8
*
R55
ICD-10 Finland
Syncope and collapse
2.1
7.4
86
439
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.4
7.4
25
58
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.7
7.4
183
1219
G40
ICD-10 Finland
Epilepsy
8.5
7.3
15
18
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
9.5
7.3
14
15
S06.6
ICD-10 Finland
Traumatic subarachnoid haemorrhage
9.5
7.3
14
15
GBB03
NOMESCO Finland
Percutaneous tracheostomy
+∞
7.3
7
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
7.3
7
*
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
7.3
7
*
OAB43
SPAT
NA
0.2
7.3
9
378
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
7.4
7.2
16
22
JDB10
NOMESCO Finland
Percutaneous gastrostomy
5.4
7.1
20
38
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
2.6
7.1
49
194
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
8.9
7.1
14
16
T36
ICD-10 Finland
Poisoning by systemic antibiotics
3.5
7.0
31
92
GBB00
NOMESCO Finland
Tracheostomy
5.9
6.9
18
31
N05AD01
ATC
haloperidol; systemic
3.5
6.9
30
88
SPAT1252
SPAT
Overall medication plan or its review
2.3
6.8
60
273
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
40.4
6.8
8
*
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
40.4
6.8
8
*
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
40.4
6.8
8
*
RL140
NOMESCO Finland
NA
16.9
6.8
10
6
XX4AW
NOMESCO Finland
NA
16.9
6.8
10
6
SPAT1301
SPAT
No procedures
1.6
6.7
219
1561
4309X
ICD-9 Finland
Subarachnoid haemorrhage[HAEMORRHAGIA SUBARACHNOIDALIS NUD]
22.8
6.7
9
*
F54
ICD-10 Finland
Psychological and behavioural factors associated with disorders or diseases classified elsewhere
22.8
6.7
9
*
N05BA04
ATC
oxazepam; oral
1.7
6.6
162
1071
G40.89
ICD-10 Finland
Other epilepsy
12.4
6.6
11
9
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.0
6.6
80
417
F06.7
ICD-10 Finland
Mild cognitive disorder
3.6
6.6
28
81
A04
ICPC
Weakness/tiredness general
1.9
6.4
96
541
RT490
NOMESCO Finland
NA
70.5
6.4
7
*
G40.11
ICD-10 Finland
Simple partial epileptic seizure that develops into a complex partial seizure
70.5
6.4
7
*
G90.1
ICD-10 Finland
Familial dysautonomia [Riley-Day]
70.5
6.4
7
*
L01AX03
ATC
temozolomide; systemic
14.5
6.4
10
7
D33.30
ICD-10 Finland
Acoustic neuroma
14.5
6.4
10
7
G41.0
ICD-10 Finland
Grand mal status epilepticus
14.5
6.4
10
7
WX882
NOMESCO Finland
High dependency care
3.3
6.4
30
94
ZXA05
NOMESCO Finland
Left side
1.6
6.4
179
1225
N05AD03
ATC
melperone; systemic
5.3
6.4
18
35
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
5.6
6.3
17
31
WW200
SPAT
NA
2.2
6.3
61
289
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.6
6.3
44
176
N30.0
ICD-10 Finland
Acute cystitis
1.9
6.3
100
578
74209
ICD-8 Finland
Congenital hydrocephalus, Unspecified
+∞
6.3
6
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
+∞
6.3
6
*
RS122
NOMESCO Finland
NA
+∞
6.3
6
*
RP120
NOMESCO Finland
NA
+∞
6.3
6
*
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
6.3
6
*
I62.9
ICD-10 Finland
Intracranial haemorrhage (nontraumatic), unspecified
+∞
6.3
6
*
Q05.2
ICD-10 Finland
Lumbar spina bifida with hydrocephalus
+∞
6.3
6
*
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
26.9
6.2
8
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.7
6.1
134
859
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
0.3
6.1
13
410
Z08
ICPC
Social welfare problem
6.8
6.1
14
21
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
0.5
6.0
58
1030
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.1
6.0
62
304

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
139
49
34.41
212.28
4.7
1.2
—
—
—
0
0
177
121
18.70
205.60
3.9
1.7
37.0
7.0
e6/l
1.95
146
90
177
121
18.70
205.60
3.9
1.8
2401.5
1077.2
e6/l
0.50
146
93
138
103
16.11
151.46
4.3
1.8
—
—
—
0
0
103
50
23.63
138.76
4.3
2.0
—
—
—
0
0
96
58
18.77
116.89
4.1
2.3
—
—
—
0
0
107
125
9.78
86.34
3.0
1.6
3.6
3.8
mmol/l
1.11
102
117
175
738
2.78
28.16
9.0
8.1
1.6
1.3
mmol/l
0.79
135
591
32
35
9.50
26.66
1.2
1.0
293.9
280.3
ng/l
0.05
11
22
32
35
9.50
26.66
1.2
1.0
484.1
552.0
ng/l
—
10
22
75
208
3.89
23.96
9.6
3.7
3.8
3.9
mmol/l
2.34
75
190
255
1384
2.26
23.24
4.7
4.0
—
—
—
0
0
28
9
32.21
21.61
3.0
1.0
33.9
—
%
—
22
0
128
527
2.71
21.16
3.6
3.6
—
—
—
0
0
78
246
3.42
20.54
9.1
3.8
1.6
1.3
mmol/l
0.70
78
240
308
1872
2.08
20.48
2.9
2.1
214.8
289.0
u/l
0.59
287
1768
77
252
3.28
19.10
10.0
4.6
—
—
—
0
0
109
440
2.72
18.63
9.3
5.7
—
—
—
0
0
105
422
2.72
18.08
15.4
8.0
24.7
24.3
mmol/l
0.29
99
404
83
1887
0.37
16.92
2.2
3.0
—
—
—
0
0
252
1528
1.97
16.06
4.9
4.1
90.2
88.4
%
0.60
242
1489
304
1976
1.89
15.63
4.7
3.4
—
—
—
0
0
157
807
2.19
15.61
8.2
7.0
105.1
104.1
mmol/l
1.70
157
787
179
985
2.07
14.83
2.5
2.2
28.8
29.7
s
0.95
171
950
21
29
7.42
14.46
2.4
2.4
60.7
49.0
umol/l
0.61
15
23
219
1347
1.88
12.91
5.6
4.3
1.0
1.0
kg/l
0.38
16
199
114
560
2.22
12.52
2.8
2.5
5.4
6.5
ug/l
0.23
100
490
249
1621
1.79
12.08
5.6
4.2
0.0
0.0
estimate
0.50
45
532
265
1776
1.75
11.53
4.8
4.3
—
—
—
0
0
231
1489
1.79
11.49
2.6
2.4
—
—
—
0
0
280
1962
1.67
10.05
2.8
2.5
—
—
—
0
0
144
855
1.84
9.18
5.8
5.9
1.0
1.1
mmol/l
1.87
136
790
454
5337
0.64
8.33
24.8
16.8
39.6
39.2
%
0.40
296
3652
114
1854
0.55
8.09
3.6
4.1
—
—
—
0
0
46
184
2.60
7.97
8.4
9.4
—
—
—
0
0
496
5682
0.64
7.55
3.8
4.5
1.4
1.5
mmol/l
2.05
457
5160
367
2891
1.52
7.33
8.6
6.4
1.2
1.2
mmol/l
2.65
346
2616
476
5490
0.65
7.33
3.8
4.1
1.4
1.3
mmol/l
2.51
443
4959
502
5723
0.65
7.27
4.3
4.7
6.0
6.0
mmol/l
0.01
473
5141
503
5725
0.65
7.13
4.0
4.5
4.5
4.6
mmol/l
0.91
465
5241
97
550
1.87
7.09
7.0
8.7
—
—
—
0
0
518
5855
0.65
7.03
4.6
5.1
2.6
2.7
mmol/l
0.72
481
5320
152
1021
1.61
6.04
3.6
3.7
0.8
0.8
mmol/l
2.25
142
958
432
3613
1.45
5.86
8.8
5.2
6.9
6.7
mmol/l
0.90
420
3391
29
675
0.41
5.64
1.1
1.3
—
—
—
0
0
6
266
0.22
5.31
1.7
1.4
—
—
—
0
0
380
3169
1.39
4.88
9.0
7.1
1.2
1.2
mmol/l
2.16
345
2689
488
5459
0.71
4.80
5.4
6.1
39.6
40.2
mmol/mol
0.94
456
5019
90
565
1.67
4.65
6.2
7.5
1.4
1.3
mmol/l
0.13
85
541
112
745
1.59
4.59
2.3
1.7
—
—
—
0
0
44
814
0.51
4.57
1.2
1.2
—
—
—
0
0
112
1610
0.64
4.45
5.0
3.7
—
—
—
0
0
132
919
1.53
4.43
2.4
2.1
—
—
—
0
0
123
844
1.54
4.41
22.7
25.0
1.3
1.3
inr
—
6
114
432
4899
0.73
4.36
26.6
19.1
13.9
13.8
%
1.00
424
4788
179
2318
0.70
4.09
2.2
2.2
—
—
—
0
0
350
2943
1.35
4.00
5.1
4.0
0.0
0.0
estimate
0.00
48
553
335
2818
1.33
3.74
4.5
4.2
—
—
—
0
0
5
197
0.25
3.57
5.4
5.4
—
—
—
0
0
24
500
0.46
3.55
6.8
3.9
—
—
—
0
0
589
6304
0.72
3.52
11.0
10.7
25.6
25.4
u/l
0.07
571
6053
322
2715
1.32
3.46
5.3
5.0
34.3
35.3
g/l
2.38
298
2529
39
685
0.55
3.43
3.2
4.1
4.3
26.6
ug/l
1.25
34
581
346
2954
1.31
3.38
6.0
5.4
0.0
0.0
estimate
0.00
49
546
18
410
0.43
3.37
1.3
1.4
—
—
—
0
0
159
1211
1.39
3.31
2.9
3.1
2.5
2.5
mmol/l
0.15
141
1066
349
2991
1.31
3.29
5.0
4.0
0.0
0.0
estimate
0.50
48
531
27
514
0.51
3.09
1.2
1.5
—
—
—
0
0
46
750
0.59
3.09
1.2
1.3
—
—
—
0
0
171
1335
1.36
3.05
3.1
2.7
5.9
5.6
e6/l
0.10
157
1174
61
923
0.63
3.01
1.1
1.3
14.5
10.1
u/ml
0.25
20
337
33
575
0.55
2.84
1.5
1.6
—
—
—
0
0
116
1526
0.72
2.76
1.2
1.3
—
—
—
0
0
214
1750
1.31
2.76
4.1
3.3
0.3
0.5
e6/l
1.45
176
1328
152
1916
0.74
2.75
3.9
4.0
8.4
8.8
mg/mmol
0.05
104
1218
206
1682
1.31
2.68
4.1
3.3
—
—
—
0
0
286
2441
1.27
2.63
3.7
3.9
27.6
54.6
ng/l
1.23
215
1798
188
1523
1.31
2.58
6.5
6.9
—
—
—
0
0
68
972
0.67
2.57
1.2
1.3
38.7
36.0
iu/ml
0.07
23
305
40
242
1.69
2.46
2.0
1.9
—
—
—
0
0
24
124
1.97
2.43
2.2
2.3
—
—
—
0
0
26
457
0.55
2.34
1.4
1.5
—
—
—
0
0
250
2125
1.26
2.33
3.1
3.5
2.4
2.4
mmol/l
0.34
219
1852
534
4942
1.26
2.32
28.4
20.3
332.2
332.1
g/l
0.04
526
4893
8
201
0.39
2.32
1.0
1.1
—
—
—
0
0
8
202
0.39
2.32
1.1
1.7
—
—
—
0
0
51
334
1.56
2.31
9.4
11.6
—
—
—
0
0
88
645
1.41
2.30
3.7
4.5
1.4
1.9
mmol/l
0.57
70
513
87
1164
0.72
2.28
2.4
3.1
0.6
0.8
ug/l
1.16
63
769
630
6591
0.76
2.26
30.9
22.7
131.9
134.3
g/l
3.63
616
6466
221
1857
1.27
2.26
4.1
4.0
7.4
7.4
ph
0.26
18
338
7
18
3.91
2.25
1.1
1.0
1701.9
1751.1
miu/ml
—
7
18
630
6589
0.76
2.23
30.8
22.5
7.2
6.8
e9/l
4.33
614
6373
630
6588
0.76
2.22
30.8
22.5
4.4
4.5
e12/l
3.20
614
6369
630
6587
0.76
2.20
30.6
22.4
30.2
30.3
pg
0.40
618
6464
630
6586
0.76
2.19
30.7
22.4
90.9
91.1
fl
0.39
617
6464
630
6585
0.76
2.18
30.7
22.5
256.7
245.9
e9/l
3.28
614
6389
30
176
1.73
2.09
5.2
3.5
—
—
—
0
0
54
772
0.68
2.06
1.2
1.3
1040.0
455.0
titre
0.79
14
168
42
274
1.56
1.96
2.7
2.0
3.8
2.6
ug/l
0.18
37
244
48
691
0.67
1.91
1.5
2.3
292.6
139.9
ug/g
0.44
39
539
128
1025
1.30
1.91
4.5
3.2
2.5
2.1
e6/l
0.22
72
570
5
139
0.36
1.90
1.0
1.1
—
—
—
0
0
153
1255
1.27
1.89
1.6
1.8
1384.2
1186.4
nmol/l
2.05
127
934
58
803
0.70
1.87
2.1
1.8
—
—
—
0
0
17
86
2.00
1.86
2.2
2.8
—
—
—
0
0
11
46
2.41
1.86
1.0
1.2
—
—
—
0
0
150
1807
0.79
1.86
3.5
3.2
833.1
298.1
mg/l
0.46
105
1160
5
12
4.19
1.82
1.4
1.9
16.2
16.5
umol/l
—
5
12
7
167
0.41
1.80
1.1
1.2
—
656.0
—
0
5
6
18
3.35
1.75
2.3
1.8
—
—
—
0
0
0
47
0.00
1.71
0.0
2.3
—
555.3
—
0
29
221
1910
1.22
1.71
4.6
3.5
48.0
93.5
e6/l
0.64
184
1479
163
1926
0.80
1.69
3.3
3.2
7.3
7.4
mmol/l
0.06
144
1599
250
2194
1.21
1.65
5.7
4.0
87.0
84.6
e6/l
0.03
201
1580
129
1558
0.79
1.62
1.6
1.7
1.5
1.4
mmol/l
1.16
113
1284
151
1261
1.25
1.61
4.0
3.0
554.5
552.9
mosm/kgh2o
0.03
137
1074
44
616
0.70
1.54
3.7
4.1
—
—
—
0
0
0
44
0.00
1.51
0.0
2.4
—
41.5
—
0
12
292
2617
1.19
1.50
6.6
10.4
1.2
1.3
inr
0.92
62
728
49
669
0.71
1.49
1.5
1.6
—
—
—
0
0
10
203
0.49
1.49
1.4
1.6
—
—
—
0
0
238
2676
0.84
1.45
8.8
9.9
0.0
0.0
e9/l
0.15
185
2174
7
154
0.45
1.44
1.1
1.2
—
68.2
—
0
11
7
29
2.43
1.39
10.3
13.2
1725.6
1578.9
nmol/l
—
7
29
23
358
0.63
1.37
1.2
1.2
—
—
—
0
0
9
41
2.21
1.37
2.6
1.6
—
—
—
0
0
175
2013
0.83
1.36
4.1
5.2
3.0
2.8
ug/l
0.06
158
1780
132
1560
0.81
1.36
2.6
2.8
343.4
7654.9
umol/l
6.74
108
1333
34
486
0.69
1.35
5.0
4.3
0.2
0.1
%
—
10
142
11
54
2.05
1.33
2.2
1.5
—
—
—
0
0
417
4461
0.86
1.33
3.7
4.2
14.9
13.1
mm/h
1.23
392
4076
11
55
2.01
1.28
1.3
1.3
35.7
32.1
mmol/l
0.32
11
50
8
35
2.30
1.27
1.4
1.5
9.9
9.3
mmol/l
—
8
30
261
2886
0.86
1.26
5.8
5.8
57.7
57.3
%
0.20
246
2697
18
290
0.61
1.26
5.0
3.0
45.1
68.0
u/ml
0.46
18
277
516
5419
0.85
1.25
4.5
4.6
2.0
2.2
mu/l
0.42
481
4863
226
2524
0.85
1.24
2.7
2.8
110.9
139.6
ug/l
2.00
212
2288
15
85
1.78
1.23
1.2
1.7
—
—
—
0
0
15
85
1.78
1.23
1.2
1.7
—
—
—
0
0
15
85
1.78
1.23
1.2
1.7
—
—
—
0
0
15
85
1.78
1.23
1.2
1.7
—
—
—
0
0
12
63
1.92
1.23
2.5
3.3
—
—
—
0
0
592
6145
0.84
1.22
20.4
14.5
—
—
—
0
0
6
26
2.32
1.19
8.7
14.3
—
—
—
0
0
0
34
0.00
1.16
0.0
1.4
—
1.0
—
0
34
266
2921
0.86
1.16
6.1
6.1
27.4
27.5
%
0.05
252
2712
0
35
0.00
1.15
0.0
2.5
—
485.1
—
0
23
5
20
2.51
1.15
2.0
2.9
—
—
—
0
0
33
458
0.71
1.14
5.2
4.3
0.9
0.8
%
0.03
11
121
251
2765
0.86
1.13
6.1
6.0
0.6
0.7
%
0.33
239
2572
177
2002
0.85
1.13
2.5
3.1
1440.4
1603.4
ng/l
0.15
157
1721
259
2844
0.87
1.12
6.1
5.9
2.7
2.9
%
0.75
246
2643
10
51
1.97
1.11
1.8
1.4
30.4
29.0
u/l
—
10
41
39
520
0.74
1.07
4.6
4.1
1.0
1.0
%
0.05
14
160
17
265
0.63
1.06
1.1
1.3
—
—
—
0
0
262
2859
0.87
1.02
6.3
6.2
8.9
8.7
%
0.26
248
2673
111
1293
0.83
1.00
5.2
4.7
—
—
—
0
0
0
29
0.00
0.98
0.0
1.6
—
71.5
—
0
23
8
144
0.55
0.94
1.8
2.3
131.3
128.3
g/l
—
8
107
42
325
1.31
0.88
2.9
3.3
0.8
0.7
%
1.81
42
315
25
343
0.72
0.85
1.1
1.2
179.4
138.8
iu/ml
0.19
13
129
13
80
1.64
0.85
1.7
1.5
—
—
—
0
0
100
1157
0.84
0.84
1.3
1.5
2.4
2.4
g/l
0.08
53
697
8
45
1.79
0.84
1.3
1.2
—
—
—
0
0
11
176
0.62
0.80
1.5
1.4
—
—
—
0
0
0
25
0.00
0.79
0.0
1.3
—
—
—
0
0
37
472
0.77
0.79
4.4
4.0
1.3
0.5
%
—
6
113
8
48
1.67
0.79
1.4
1.2
1.1
1.5
nmol/l
—
8
42
149
1331
1.15
0.78
1.4
1.7
466.4
5249056.8
pmol/l
0.50
127
1086
5
97
0.51
0.78
1.2
1.0
—
—
—
0
0
0
28
0.00
0.76
0.0
1.5
—
—
—
0
0
115
1296
0.87
0.71
1.2
1.3
0.7
1.8
u/ml
2.57
33
338
19
263
0.72
0.71
1.0
1.6
—
11.8
—
0
8
29
221
1.32
0.70
10.8
3.8
8.7
8.5
kpa
0.26
29
204
34
429
0.78
0.68
1.5
1.5
—
—
—
0
0
5
27
1.86
0.68
4.4
5.6
—
—
—
0
0
7
43
1.63
0.67
2.1
3.2
—
—
—
0
0
167
1525
1.12
0.64
1.5
1.6
20.6
20.6
nmol/l
0.00
154
1274
39
479
0.80
0.64
2.3
2.9
10.6
10.4
g/l
0.09
34
440
6
104
0.57
0.62
6.0
2.6
—
—
—
0
0
6
105
0.57
0.62
3.0
3.4
4.9
4.5
e9/l
—
6
105
5
30
1.67
0.61
1.0
1.3
123.0
141.6
nmol/l
—
5
30
0
20
0.00
0.60
0.0
1.1
—
1.6
—
0
13
32
399
0.79
0.60
3.5
2.9
3.8
4.0
e9/l
0.29
23
311
134
1213
1.13
0.60
3.9
4.0
312.2
295.6
ng/l
0.03
109
989
0
22
0.00
0.59
0.0
1.5
—
—
—
0
0
64
549
1.18
0.59
2.0
3.2
67.2
66.3
g/l
0.45
56
502
0
23
0.00
0.58
0.0
2.4
—
—
—
0
0
51
597
0.84
0.53
1.7
1.5
—
—
—
0
0
9
63
1.43
0.52
1.6
1.3
568975.6
190422.2
e6/l
—
9
44
30
369
0.81
0.52
1.3
1.4
—
—
—
0
0
26
325
0.79
0.52
2.8
4.3
—
—
—
0
0
26
206
1.27
0.51
1.5
2.8
38.9
37.7
g/l
0.48
19
176
15
202
0.74
0.51
1.1
1.1
—
—
—
0
0
27
335
0.80
0.51
1.7
1.6
—
—
—
0
0
7
109
0.64
0.48
1.0
1.4
—
—
—
0
0
26
322
0.80
0.48
2.7
2.4
—
—
—
0
0
7
110
0.63
0.48
3.3
3.8
56.1
59.3
%
—
7
110
53
457
1.17
0.48
2.1
2.8
—
—
—
0
0
5
83
0.60
0.46
3.2
2.1
34.0
33.0
pg
—
5
83
49
565
0.86
0.45
2.2
2.3
37.0
118.0
u/l
0.46
37
470
12
163
0.73
0.44
1.7
1.4
—
—
—
0
0
9
129
0.69
0.43
4.0
2.8
—
—
—
0
0
6
94
0.64
0.42
1.7
2.9
—
—
—
0
0
38
444
0.85
0.41
1.2
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.5
—
—
—
0
0
0
16
0.00
0.41
0.0
1.3
—
—
—
0
0
26
314
0.82
0.40
1.5
1.3
—
—
—
0
0
0
18
0.00
0.40
0.0
1.4
—
—
—
0
0
5
35
1.43
0.39
1.4
1.1
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
—
—
0
0
8
111
0.72
0.37
1.0
1.7
—
—
—
0
0
266
2548
1.07
0.36
2.0
2.0
94.0
94.2
pmol/l
0.03
140
1316
14
179
0.78
0.36
1.2
1.4
329.6
285.3
ug/g
—
9
101
154
1636
0.93
0.35
2.2
2.2
3.0
3.1
mg/l
0.12
136
1377
14
177
0.79
0.33
5.0
6.2
1.6
1.5
mg/l
0.13
14
160
24
285
0.84
0.33
1.0
1.2
—
26.8
—
0
9
10
132
0.75
0.32
2.3
2.6
16.8
16.1
%
—
5
72
13
164
0.79
0.31
1.6
1.4
—
—
—
0
0
12
153
0.78
0.31
1.6
1.4
—
—
—
0
0
7
53
1.32
0.31
1.1
1.2
—
—
—
0
0
7
100
0.70
0.30
1.3
1.2
—
—
—
0
0
7
55
1.28
0.30
2.3
2.4
—
—
—
0
0
185
1938
0.94
0.29
2.4
2.5
54.4
56.6
u/l
0.32
174
1781
19
159
1.20
0.27
1.6
1.8
32732.1
13679.5
e6/l
0.44
14
118
5
72
0.69
0.26
1.6
1.2
—
—
—
0
0
21
245
0.85
0.25
1.7
3.8
0.5
0.4
g/l
—
8
100
334
3253
1.05
0.24
5.5
6.3
10.5
12.3
umol/l
2.05
315
3075
22
189
1.17
0.24
1.2
1.2
—
—
—
0
0
9
77
1.17
0.24
1.4
1.2
—
—
—
0
0
10
78
1.29
0.24
1.4
1.5
—
—
—
0
0
50
546
0.91
0.23
2.5
3.3
195.8
235.0
ng/l
0.35
44
502
0
11
0.00
0.21
0.0
5.3
—
—
—
0
0
0
11
0.00
0.21
0.0
4.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
10.8
—
0
5
0
11
0.00
0.21
0.0
2.1
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
2.4
—
6188.2
—
0
12
198
2049
0.95
0.21
6.0
6.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
13.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.2
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
1.7
—
0
8
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
18.4
—
0
14
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
9
114
0.79
0.20
2.1
1.6
—
—
—
0
0
6
50
1.20
0.19
2.0
2.1
—
—
—
0
0
14
165
0.85
0.19
1.6
1.4
—
—
—
0
0
428
4208
1.04
0.19
5.8
4.5
—
—
—
0
0
16
137
1.17
0.19
3.1
3.4
—
—
—
0
0
7
59
1.19
0.18
1.0
1.1
—
—
—
0
0
12
142
0.84
0.17
2.2
1.7
35.1
40.7
nmol/l
0.54
12
135
361
3544
1.04
0.17
9.2
9.1
4.6
4.2
e9/l
2.08
316
3089
5
68
0.73
0.17
1.6
2.4
—
—
—
0
0
5
70
0.71
0.16
1.2
1.2
—
—
—
0
0
14
162
0.86
0.16
1.6
1.4
—
—
—
0
0
6
76
0.79
0.15
1.3
1.2
—
—
—
0
0
6
76
0.79
0.15
1.2
1.1
—
—
—
0
0
44
411
1.07
0.14
4.0
3.1
—
—
—
0
0
128
1323
0.96
0.14
2.2
1.8
1.4
1.3
mg/l
0.13
101
1031
591
5957
0.97
0.13
23.0
15.4
27.5
24.7
mg/l
1.16
505
4755
29
267
1.09
0.13
2.3
2.8
—
—
—
0
0
9
110
0.82
0.13
2.2
1.5
—
—
—
0
0
51
539
0.94
0.12
1.5
1.4
—
—
—
0
0
11
127
0.86
0.12
1.6
1.4
—
—
—
0
0
13
146
0.89
0.10
1.1
1.3
—
—
—
0
0
30
280
1.07
0.10
1.3
2.0
1.5
1.5
g/l
0.13
24
248
97
1001
0.96
0.10
2.6
2.5
12.4
12.6
umol/l
0.10
91
926
14
156
0.90
0.10
1.1
1.2
—
—
—
0
0
306
3018
1.02
0.10
5.6
5.8
0.6
0.6
e9/l
0.35
259
2591
5
45
1.11
0.10
2.6
1.9
7.6
6.8
mmol/l
—
5
31
75
725
1.04
0.09
1.6
1.4
—
—
—
0
0
73
754
0.96
0.08
1.9
2.9
1.9
1.8
%
0.26
65
677
5
62
0.81
0.08
1.0
1.1
—
—
—
0
0
7
68
1.03
0.08
1.6
2.6
—
—
—
0
0
6
71
0.84
0.07
1.2
1.2
—
—
nmol/l
—
0
0
6
74
0.81
0.07
7.5
3.8
—
—
—
0
0
465
4683
0.98
0.07
6.8
7.6
82.5
80.8
u/l
0.32
444
4363
16
147
1.09
0.07
1.2
1.7
—
—
—
0
0
7
81
0.86
0.07
1.3
1.2
0.5
0.6
nmol/l
—
7
74
58
561
1.04
0.07
2.0
2.8
75.0
69.0
e9/l
0.63
43
431
54
522
1.04
0.06
4.1
3.8
85.3
83.5
ng/l
0.06
44
456
16
148
1.08
0.06
2.6
5.0
—
—
—
0
0
19
203
0.93
0.06
1.4
1.2
0.3
1.8
u/ml
—
5
16
90
920
0.98
0.06
2.7
2.5
2.2
2.3
g/l
1.85
85
857
306
3033
1.01
0.06
5.7
5.8
0.0
0.0
e9/l
0.37
259
2614
618
6201
0.98
0.05
24.7
18.3
4.0
4.0
mmol/l
1.88
607
6022
12
110
1.09
0.05
1.4
1.6
—
—
—
0
0
312
3096
1.01
0.05
6.0
5.9
1.9
1.9
e9/l
0.00
268
2718
85
864
0.98
0.03
2.9
2.5
23.9
22.2
%
0.43
77
743
13
139
0.93
0.03
1.6
1.6
2.0
6.3
iu/l
—
5
39
454
4523
1.01
0.03
3.7
3.8
15.0
14.9
pmol/l
0.21
415
4028
36
352
1.02
0.01
8.9
4.1
—
—
—
0
0
423
4237
1.00
0.00
3.9
4.0
—
—
—
0
0
313
3136
1.00
0.00
6.2
6.1
0.2
0.2
e9/l
0.14
272
2746
10
105
0.95
0.00
1.4
1.6
—
—
—
0
0
16
164
0.98
0.00
4.1
4.3
—
—
—
0
0
10
98
1.02
0.00
1.5
1.4
—
—
—
0
0
35
352
0.99
0.00
5.1
3.0
0.2
0.3
e6/l
0.10
35
340
10
101
0.99
0.00
1.0
1.2
—
—
—
0
0
618
6183
1.00
0.00
25.7
18.2
139.4
139.6
mmol/l
1.21
607
6011
6
60
1.00
0.00
1.0
1.1
—
—
—
0
0
6
60
1.00
0.00
1.2
1.3
—
—
—
0
0
5
55
0.91
0.00
3.6
5.9
11.5
10.8
%
—
5
55
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
8
79
1.01
0.00
1.5
1.9
89.3
89.5
%
—
8
79
0
8
0.00
0.00
0.0
7.5
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
41.6
—
0
8
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
0.1
—
0
5
0
5
0.00
0.00
0.0
4.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.4
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.6
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
72
720
1.00
0.00
2.2
3.0
8.2
8.1
umol/l
0.01
59
625
0
9
0.00
0.00
0.0
1.0
—
17.4
—
0
9
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
14.9
—
0.5
—
0
8
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint G6_HCCOMM and mortality.

Females

Parameter HR [95% CI] p-value
G6_HCCOMM 3.207 [2.83, 3.63] < 0.001
Birth year 0.997 [0.99, 1.01] 0.446

During the follow-up period (1.1.1998 — 31.12.2019), 862 out of 2207 females with G6_HCCOMM died.

Males

Parameter HR [95% CI] p-value
G6_HCCOMM 3.268 [2.82, 3.79] < 0.001
Birth year 0.988 [0.98, 1.0] 0.014

During the follow-up period (1.1.1998 — 31.12.2019), 835 out of 2089 males with G6_HCCOMM died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCCOMM.

N-year risk Females Males
1 0.237% 0.734%
5 1.673% 3.6%
10 4.418% 9.74%
15 9.011% 17.976%
20 15.437% 29.439%

Relationships between endpoints

Index endpoint: G6_HCCOMM – Communicating hydrocephalus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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