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Other and unspecified hydrocephalus

DOID EFO Endpoint Browser PheWeb

G6_HCOTHUNS

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — G91.8, G91.9
  • Hospital discharge: ICD-8 — 34793
  • Cause of death: ICD-10 — G91.8, G91.9
  • Cause of death: ICD-8 — 34793

2 out of 7 registries used, show all original rules.

698

4. Check minimum number of events

None

698

5. Include endpoints

None

698

6. Filter based on genotype QC (FinnGen only)

679

Control definitions (FinnGen only)

Control exclude
G6_HYDROCEPH

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6159 3013 3080
Only index persons 4640 2370 2270
Unadjusted period prevalence (%)
Whole population 0.09 0.09 0.09
Only index persons 0.09 0.09 0.09
Median age at first event (years)
Whole population 56.12 58.51 53.59
Only index persons 54.55 57.40 51.57

-FinnGen-

Key figures

All Female Male
Number of individuals 679 376 303
Unadjusted period prevalence (%) 0.14 0.13 0.14
Median age at first event (years) 60.62 59.11 62.48

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
698
Matched controls
6980
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
+∞
321.5
283
*
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
+∞
307.7
562
*
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
5973.9
307.7
341
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
2722.2
204.6
188
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
+∞
196.4
179
*
G91.1
ICD-10 Finland
Obstructive hydrocephalus
+∞
196.4
179
*
AA1AA
NOMESCO Finland
Head X-ray examination
67.7
188.4
104
18
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
18.1
182.6
160
113
G91.8
ICD-10 Finland
Other hydrocephalus
+∞
172.2
158
*
AA1AD
NOMESCO Finland
CT of head and brain
7.4
154.5
435
1281
AAF00
NOMESCO Finland
Ventriculostomy
526.6
135.0
130
*
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
+∞
129.3
120
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
7.7
106.9
177
296
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
+∞
103.8
97
*
I69.0
ICD-10 Finland
Sequelae of subarachnoid haemorrhage
31.4
95.2
63
22
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
+∞
91.7
86
*
N03AX14
ATC
levetiracetam; systemic
13.2
79.4
79
67
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
5.7
73.2
161
349
AAF15
NOMESCO Finland
Ventriculoatrial shunt
+∞
71.1
67
*
I60.9
ICD-10 Finland
Subarachnoid haemorrhage, unspecified
16.7
69.9
60
39
AAF99
NOMESCO Finland
Other shunt operation on ventricle of brain or intracerebral cyst
713.4
67.1
65
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
5.5
63.6
141
306
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.3
63.5
101
158
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
11.3
58.7
64
62
R51.80
ICD-10 Finland
Headache
4.1
56.8
200
624
G40.9
ICD-10 Finland
Epilepsy, unspecified
8.8
56.0
74
93
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.7
55.8
68
77
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
11.0
51.7
57
56
AAF50
NOMESCO Finland
Third ventriculostomy
+∞
50.6
48
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
10.7
45.6
51
51
N03AG01
ATC
valproic acid; systemic, rectal
5.4
45.4
98
205
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
14.3
41.1
38
28
N29
ICPC
Neurological sympt/complt other
10.9
40.8
45
44
AAA20
NOMESCO Finland
Insertion of intraventricular pressure monitoring device
409.5
39.5
39
*
ZXD05
NOMESCO Finland
Urgent procedure
2.9
38.8
293
1410
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
14.0
38.5
36
27
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
3.1
38.2
205
816
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
6.6
38.1
64
105
XA800
NOMESCO Finland
Neuropsychological investigation
5.8
37.9
73
137
I69.1
ICD-10 Finland
Sequelae of intracerebral haemorrhage
11.4
36.7
39
36
34793
ICD-8 Finland
Other disease of brain, Hydrocephalus acquisitus NUD
+∞
33.6
32
*
Y83
ICD-10 Finland
Surgical operation and other surgical procedures as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
4.1
33.3
103
286
Z98.2
ICD-10 Finland
Presence of cerebrospinal fluid drainage device
+∞
32.6
31
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.0
31.8
179
724
N18
ICPC
Paralysis/weakness
8.6
31.5
41
50
L28
ICPC
Limited function/disability (L)
2.8
30.3
189
806
TAB00
NOMESCO Finland
Lumbar puncture
4.9
29.8
69
152
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
9.2
29.2
36
41
N03AF02
ATC
oxcarbazepine; oral
6.1
28.9
52
91
N28
ICPC
Limited function/disability (N)
9.4
28.8
35
39
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.9
28.0
165
680
PA2CC
NOMESCO Finland
Cerebral very extensive angiography with X-ray
26.7
27.8
38
15
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
7.7
27.4
39
53
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
+∞
27.3
26
*
G04BD07
ATC
tolterodine; oral
4.3
26.2
72
182
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.9
24.3
76
211
ZXE10
NOMESCO Finland
More than one and less than three hours
2.3
24.2
310
1815
2132
FHL
Ventricular operators sunt
+∞
24.1
23
*
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.3
23.9
65
163
SPAT1229
SPAT
Assessment of need for aid
3.4
23.4
91
293
G97.2
ICD-10 Finland
Intracranial hypotension following ventricular shunting
+∞
23.0
22
*
A28
ICPC
Limited function/disability NOS
2.5
22.9
181
856
F03
ICD-10 Finland
Unspecified dementia
4.2
22.7
63
160
K90
ICPC
Stroke/cerebrovascular accident
5.4
22.7
46
90
I62.0
ICD-10 Finland
Nontraumatic subdural haemorrhage
22.3
22.3
32
15
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
7.6
22.2
32
44
R42
ICD-10 Finland
Dizziness and giddiness
2.3
21.5
204
1044
WX408
NOMESCO Finland
General anesthesy, balanced
2.3
21.2
220
1169
N03AB02
ATC
phenytoin; systemic
7.9
20.9
29
38
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.3
20.9
84
275
G91.3
ICD-10 Finland
Post-traumatic hydrocephalus, unspecified
+∞
20.9
20
*
Q03.9
ICD-10 Finland
Congenital hydrocephalus, unspecified
+∞
20.9
20
*
Y83.1
ICD-10 Finland
Surgical operation with implant of artificial internal device as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
7.7
20.5
29
39
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
16.7
20.3
32
20
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
6.8
20.2
32
49
SPAT1216
SPAT
Assessment of functional ability
2.5
20.1
153
706
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
5.4
20.1
40
77
3314A
ICD-9 Finland
Other cerebral degenerations, Obstructive hydrocephalus
+∞
19.9
19
*
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
6.2
19.7
34
57
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
15.2
19.6
32
22
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
19.3
148
685
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.9
19.1
101
388
G93.0
ICD-10 Finland
Cerebral cysts
35.4
19.0
24
7
TAA40
NOMESCO Finland
Cathetrisation of cerebrospinal fluid through skin
+∞
18.8
18
*
2133
FHL
Suntin revisio
+∞
18.8
18
*
H53.4
ICD-10 Finland
Visual field defects
6.2
18.4
32
54
H47.2
ICD-10 Finland
Optic atrophy
45.3
18.3
22
5
R53
ICD-10 Finland
Malaise and fatigue
2.2
18.3
209
1144
PA2MT
NOMESCO Finland
Endovascular closure of very extensive brain aneurysm
97.6
17.6
19
*
I61.9
ICD-10 Finland
Intracerebral haemorrhage, unspecified
6.2
17.4
30
50
G04BD08
ATC
solifenacin; oral
3.1
16.9
76
266
G91
ICD-10 Finland
Hydrocephalus
+∞
16.7
16
*
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.9
16.7
85
319
G93.2
ICD-10 Finland
Benign intracranial hypertension
92.3
16.6
18
*
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
14.7
16.4
27
19
N05BA09
ATC
clobazam; oral
17.2
16.2
25
15
R41.0
ICD-10 Finland
Disorientation, unspecified
4.4
16.2
41
97
N04BA02
ATC
levodopa and decarboxylase inhibitor; oral
3.9
15.2
45
120
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.9
15.0
256
1601
I60.1
ICD-10 Finland
Subarachnoid haemorrhage from middle cerebral artery
15.5
15.0
24
16
N05AH03
ATC
olanzapine; systemic
3.2
14.9
62
207
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
14.9
79
303
N05AH04
ATC
quetiapine; oral
2.2
14.8
144
732
N30.0
ICD-10 Finland
Acute cystitis
2.3
14.7
134
664
Q03.0
ICD-10 Finland
Malformations of aqueduct of Sylvius
+∞
14.6
14
*
M03BX01
ATC
baclofen; systemic
5.6
14.6
28
52
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
2.5
14.4
104
465
PA2KT
NOMESCO Finland
Endovascular closure of brain aneurysm
27.8
14.3
19
7
N99
ICPC
Neurological disease other
10.8
14.3
27
26
N03AX09
ATC
lamotrigine; oral
3.7
14.3
46
130
R32
ICD-10 Finland
Unspecified urinary incontinence
4.7
14.1
33
73
N06AB04
ATC
citalopram; systemic
2.1
14.0
166
910
N05BA01
ATC
diazepam; systemic, rectal
2.3
13.6
115
550
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.2
13.5
137
706
P20
ICPC
Memory disturbance
2.2
13.5
128
642
183
Kela drug reimbursment
Lamotrigin and topiramate
11.8
13.4
24
21
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
3.9
13.3
40
108
T81.4
ICD-10 Finland
Infection following a procedure, not elsewhere classified
2.4
13.2
96
429
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.6
13.1
25
46
U04
ICPC
Incontinence urine
3.0
13.1
59
206
PA2AD
NOMESCO Finland
CT angiography of brain
17.1
13.0
20
12
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
13.0
131
674
I60.7
ICD-10 Finland
Subarachnoid haemorrhage from intracranial artery, unspecified
51.0
12.9
15
*
A06AD11
ATC
lactulose; oral
2.1
12.8
135
705
N05CD08
ATC
midazolam; nasal, systemic
4.3
12.8
33
79
N03AX18
ATC
lacosamide; systemic
14.4
12.8
21
15
H47.1
ICD-10 Finland
Papilloedema, unspecified
14.4
12.8
21
15
A41.9
ICD-10 Finland
Sepsis, unspecified
3.8
12.8
40
111
SPAT1301
SPAT
No procedures
1.9
12.7
243
1562
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
12.5
12
*
2130
FHL
Ventricular atrial shunt
+∞
12.5
12
*
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
12.5
12
*
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
132.3
12.5
13
*
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.6
12.4
41
118
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
2.9
12.4
62
230
N05AX08
ATC
risperidone; systemic
2.5
12.2
85
372
XKC03
NOMESCO Finland
Water cystometry
4.0
12.2
35
91
I60.2
ICD-10 Finland
Subarachnoid haemorrhage from anterior communicating artery
16.2
12.2
19
12
S06.0
ICD-10 Finland
Concussion
2.3
12.2
97
452
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.4
12.1
94
433
SPAT1254
SPAT
Administration of medicine
2.1
12.1
126
655
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
10.3
12.1
23
23
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.5
12.0
78
331
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.6
12.0
72
294
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.0
12.0
157
888
PA3AC
NOMESCO Finland
Carotis angiography with X-ray
15.0
11.8
19
13
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
4.5
11.8
29
67
R11
ICD-10 Finland
Nausea and vomiting
2.5
11.7
81
354
Z01.0
ICD-10 Finland
Examination of eyes and vision
2.0
11.7
146
811
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
23.3
11.6
16
7
SPAT1167
SPAT
Insertion of urinary catheter
3.9
11.6
34
90
T85.7
ICD-10 Finland
Infection and inflammatory reaction due to other internal prosthetic devices, implants and grafts
+∞
11.5
11
*
SPAT1262
SPAT
Handing over of treatment supplies
2.0
11.5
135
734
XCK00
NOMESCO Finland
Perimetry
2.8
11.4
58
217
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
3.4
11.2
40
121
N03AF01
ATC
carbamazepine; oral, rectal
2.9
11.1
52
186
T90.5
ICD-10 Finland
Sequelae of intracranial injury
9.4
11.1
22
24
WYA20
NOMESCO Finland
Home visit
4.9
11.0
24
50
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.3
11.0
94
450
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.1
10.8
111
572
G04BD12
ATC
mirabegron; oral
2.2
10.7
103
517
WX402
NOMESCO Finland
General anaesthesia
1.9
10.7
147
843
N05AB03
ATC
perphenazine; systemic, rectal
3.6
10.6
35
101
H53.2
ICD-10 Finland
Diplopia
3.6
10.6
35
101
G81.1
ICD-10 Finland
Spastic hemiplegia
111.6
10.4
11
*
G94.2
ICD-10 Finland
Hydrocephalus in other diseases classified elsewhere
+∞
10.4
10
*
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
10.4
10
*
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
10.4
57
1266
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.8
10.4
202
1291
SPAT1053
SPAT
Memory test
2.0
10.3
122
662
ZXC86
NOMESCO Finland
Use of endoscopic device
19.1
10.3
15
8
R50.9
ICD-10 Finland
Fever, unspecified
2.0
10.2
118
636
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.9
10.2
47
167
T81.3
ICD-10 Finland
Disruption of operation wound, not elsewhere classified
4.4
10.1
25
58
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
4.9
10.1
22
46
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.0
10.0
45
157
WX882
NOMESCO Finland
High dependency care
3.5
9.8
34
101
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.6
9.8
23
51
AA1BD
NOMESCO Finland
Extensive CT of head and brain
4.2
9.8
26
64
AAL00
NOMESCO Finland
Endovascular occlusion of intracranial aneurysm
55.8
9.7
11
*
WX730
NOMESCO Finland
Conventional respirator
7.3
9.6
22
31
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
2.6
9.5
57
232
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
4.2
9.5
25
61
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
9.4
78
368
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
101.4
9.4
10
*
I60.4
ICD-10 Finland
Subarachnoid haemorrhage from basilar artery
101.4
9.4
10
*
G00.9
ICD-10 Finland
Bacterial meningitis, unspecified
30.5
9.4
12
*
AAK80
NOMESCO Finland
Partial excision of skull cap
+∞
9.4
9
*
PA2YT
NOMESCO Finland
Cerebral artery PTA with stent
22.0
9.4
13
6
SPAT1221
SPAT
Guidance concerning rehabilitation services and livelihood
5.0
9.4
20
41
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
3.9
9.3
27
71
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
7.4
9.3
21
29
GBB00
NOMESCO Finland
Tracheostomy
7.9
9.2
20
26
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.4
9.2
23
54
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
10.2
9.1
17
17
I60.0
ICD-10 Finland
Subarachnoid haemorrhage from carotid siphon and bifurcation
15.8
9.1
14
9
G81.9
ICD-10 Finland
Hemiplegia, unspecified
8.1
8.9
19
24
N06DA02
ATC
donepezil; oral
2.4
8.9
63
278
SPAT1231
SPAT
Assessment of adjustments needed in living environment
4.5
8.7
21
48
ZXD00
NOMESCO Finland
Emergency procedure
3.7
8.6
27
75
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
8.4
8.6
18
22
G41.9
ICD-10 Finland
Status epilepticus, unspecified
11.8
8.6
15
13
WX704
NOMESCO Finland
Intubation
2.4
8.6
59
257
G40.10
ICD-10 Finland
Simple partial seizures
10.2
8.6
16
16
I60.3
ICD-10 Finland
Subarachnoid haemorrhage from posterior communicating artery
27.9
8.5
11
*
N06AX11
ATC
mirtazapine; oral
1.7
8.5
234
1632
L29
ICPC
Musculoskeletal sympt/complt other
2.3
8.4
67
311
D43.1
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Brain, infratentorial
91.1
8.4
9
*
AAF45
NOMESCO Finland
Fenestration of intracranial cyst
+∞
8.3
8
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
10.9
8.3
15
14
Z2445
NOMESCO Finland
Psychologist
2.9
8.2
38
135
PA2BG
NOMESCO Finland
MRI examination of vessels in the head with high intensity magnet
14.7
8.2
13
9
ZSA00
NOMESCO Finland
Procedure related to previous procedure classified in chapter A
33.8
8.1
10
*
N06AB10
ATC
escitalopram; oral
1.8
8.0
133
806
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.5
7.9
50
209
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
7.9
7.9
17
22
F06.7
ICD-10 Finland
Mild cognitive disorder
3.3
7.9
30
95
I61.0
ICD-10 Finland
Intracerebral haemorrhage in hemisphere, subcortical
6.2
7.9
20
33
S01EC01
ATC
acetazolamide; systemic
3.6
7.9
26
75
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
7.8
202
1380
XKD03
NOMESCO Finland
Urethral pressure profilometry
3.7
7.8
24
66
I61.5
ICD-10 Finland
Intracerebral haemorrhage, intraventricular
45.5
7.7
9
*
I60.6
ICD-10 Finland
Subarachnoid haemorrhage from other intracranial arteries
45.5
7.7
9
*
ABE50
NOMESCO Finland
Occipitocervical decompression
45.5
7.7
9
*
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
45.5
7.7
9
*
SPAT1234
SPAT
Support of social functional capacity
2.5
7.7
46
188
G95.0
ICD-10 Finland
Syringomyelia and syringobulbia
18.6
7.6
11
6
G03.9
ICD-10 Finland
Meningitis, unspecified
18.6
7.6
11
6
Q07.0
ICD-10 Finland
Arnold-Chiari syndrome
25.3
7.6
10
*
G04BD04
ATC
oxybutynin; oral, transdermal
2.3
7.6
56
252
N02AA05
ATC
oxycodone; systemic
1.8
7.6
133
817
N03AE01
ATC
clonazepam; systemic
2.6
7.6
44
177
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
7.6
99
555
G20
ICD-10 Finland
Parkinson disease
3.2
7.5
30
98
XKD00
NOMESCO Finland
Uroflowmetry
1.9
7.5
106
609
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.5
7.5
18
41
J01EA01
ATC
trimethoprim; systemic
1.7
7.4
186
1258
F05.9
ICD-10 Finland
Delirium, unspecified
3.8
7.4
22
59
D33.30
ICD-10 Finland
Acoustic neuroma
13.5
7.4
12
9
XX1XW
NOMESCO Finland
Extensive written report from radiologist
4.1
7.4
20
50
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
7.4
101
574
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
9.5
7.3
14
15
R60.0
ICD-10 Finland
Localized oedema
1.9
7.3
90
494
G94.1
ICD-10 Finland
Hydrocephalus in neoplastic disease
+∞
7.3
7
*
AAW99
NOMESCO Finland
Other intracranial operation
+∞
7.3
7
*
2139
FHL
Other measure in this category
+∞
7.3
7
*
N30.9
ICD-10 Finland
Cystitis, unspecified
2.4
7.3
50
218
SPAT1245
SPAT
Provision of support and information to patient’s family members
2.6
7.2
40
157
G04BD09
ATC
trospium; oral
3.4
7.2
25
75
R26.0
ICD-10 Finland
Ataxic gait
30.3
7.2
9
*
N05AX12
ATC
aripiprazole; systemic
3.2
7.1
28
91
PA2AC
NOMESCO Finland
Cerebral angiography with X-ray
10.2
7.1
13
13
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
5.9
6.9
18
31
N06AX16
ATC
venlafaxine; oral
1.9
6.9
94
533
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
2.8
6.9
34
126
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
6.8
6.8
16
24
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
9.4
6.8
13
14
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.7
6.8
21
58
R5110, ,
SPAT
2.3
6.8
52
238
N04AA02
ATC
biperiden; systemic
4.0
6.7
19
49
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
6.7
96
553
PA4AC
NOMESCO Finland
Vertebralis angiography with X-ray
22.8
6.7
9
*
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.7
595
5343
UKC02
NOMESCO Finland
Cystoscopy
1.8
6.5
112
683
Y83.9
ICD-10 Finland
Surgical procedure, unspecified as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
3.0
6.5
28
96
N03AX11
ATC
topiramate; oral
3.5
6.5
22
65
N05CF01
ATC
zopiclone; oral
1.5
6.5
226
1648
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
2.9
6.4
29
102
Q04.6
ICD-10 Finland
Congenital cerebral cysts
70.5
6.4
7
*
R33
ICD-10 Finland
Retention of urine
2.1
6.4
64
326
Z02.7
ICD-10 Finland
Issue of medical certificate
2.2
6.4
53
251
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
6.6
6.4
15
23
N80
ICPC
Head injury other
3.5
6.3
21
61
G40.89
ICD-10 Finland
Other epilepsy
11.2
6.3
11
10
R27.0
ICD-10 Finland
Ataxia, unspecified
11.2
6.3
11
10
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
18.2
6.3
9
5
R55
ICD-10 Finland
Syncope and collapse
1.9
6.3
86
489
C71.60
ICD-10 Finland
Malignant tumor of cerebellum without histology
+∞
6.3
6
*
AAK85
NOMESCO Finland
Replantation of previously excised part of skull cap
+∞
6.3
6
*
P52.2
ICD-10 Finland
Intraventricular (nontraumatic) haemorrhage, grade 3, and grade 4 of fetus and newborn
+∞
6.3
6
*
WX110
NOMESCO Finland
Infiltration anesthesia
1.5
6.3
450
3805
G41.2
ICD-10 Finland
Complex partial status epilepticus
26.9
6.2
8
*
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
5.1
6.2
18
36
JDB10
NOMESCO Finland
Percutaneous gastrostomy
5.8
6.2
16
28
S72.0
ICD-10 Finland
Fracture of neck of femur
2.5
6.1
38
158
G40.09
ICD-10 Finland
Other or unspecified partial (focal) idiopathic epilepsy or epileptic syndrome with local onset
12.7
6.1
10
8
ZXA00
NOMESCO Finland
Right side
1.6
6.0
185
1306
TJD20
NOMESCO Finland
Change of gastrostomy tube
10.1
6.0
11
11

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
166
44
49.19
277.39
3.1
1.2
—
—
—
0
0
205
114
25.04
266.33
3.0
1.4
1251.42
1203.84
e6/l
0.01
178
82
205
114
25.04
266.33
3.0
1.3
25.40
7.68
e6/l
1.43
170
79
212
129
23.17
264.35
2.5
1.3
506.48
511.48
mg/l
0.03
207
122
168
102
21.37
207.71
3.1
1.4
—
—
—
0
0
111
47
27.89
158.45
2.6
1.4
—
—
—
0
0
70
58
13.30
71.25
2.9
1.5
—
—
—
0
0
52
33
16.95
61.21
1.1
1.0
579.21
612.70
ng/l
0.11
24
23
52
33
16.95
61.21
1.1
1.0
236.10
282.22
ng/l
0.54
21
23
53
72
7.88
37.37
5.5
5.7
10.61
11.09
mg/l
0.27
48
65
284
1694
2.14
20.31
2.8
2.1
153.78
296.40
u/l
1.66
269
1593
459
3291
2.15
20.01
8.6
5.0
6.66
6.67
mmol/l
0.03
448
3083
394
2678
2.08
19.67
13.1
15.5
1.18
1.27
inr
1.32
137
758
295
1816
2.08
19.13
4.9
3.2
—
—
—
0
0
139
644
2.45
17.98
10.4
8.1
1.82
1.33
mmol/l
1.13
115
514
259
1556
2.06
17.62
5.6
4.2
—
—
—
0
0
96
383
2.75
16.83
11.0
6.0
—
—
—
0
0
322
2156
1.92
15.51
4.2
3.8
70.01
57.11
ng/l
0.13
240
1540
396
2848
1.90
15.20
9.2
6.8
1.21
1.22
mmol/l
1.09
326
2423
241
1479
1.96
14.94
6.6
4.0
0.00
0.00
estimate
0.50
83
495
367
2615
1.85
14.11
9.6
6.3
1.20
1.21
mmol/l
4.37
343
2379
41
115
3.73
12.88
1.8
1.5
91.92
63.96
mmol/l
2.54
36
98
157
876
2.02
12.48
3.8
3.5
0.83
0.81
mmol/l
1.35
143
815
213
1383
1.78
10.37
4.3
3.8
90.33
89.25
%
0.26
206
1352
186
1173
1.80
9.93
3.8
3.0
512.88
539.13
mosm/kgh2o
0.88
171
1004
57
229
2.62
9.79
11.8
4.7
—
—
—
0
0
52
208
2.62
9.02
9.8
4.0
1.49
1.38
mmol/l
0.21
52
202
128
754
1.85
8.42
5.8
5.6
1.00
1.07
mmol/l
2.80
118
693
89
463
2.06
8.41
3.9
3.5
—
—
—
0
0
452
3706
1.62
8.32
7.2
4.7
4731.11
2854.58
e6/l
—
9
66
71
342
2.20
8.18
10.5
9.0
95.31
94.31
%
1.12
71
337
87
454
2.05
8.15
5.5
3.8
1.22
1.22
mmol/l
0.55
78
394
55
240
2.40
7.97
2.9
1.9
0.85
2.44
ug/l
0.72
48
211
35
123
2.94
7.75
5.4
3.4
—
—
—
0
0
349
2724
1.56
7.67
6.1
3.9
0.00
0.00
estimate
0.50
89
540
181
1212
1.67
7.54
3.5
2.6
7.09
5.46
e6/l
0.73
171
1093
34
121
2.90
7.37
3.5
2.5
17.39
15.99
%
1.31
20
59
186
1261
1.65
7.36
6.5
4.1
1.02
1.02
kg/l
0.04
22
181
131
808
1.76
7.34
2.2
2.0
—
—
—
0
0
167
1106
1.67
7.22
2.0
1.8
1368.88
1177.26
nmol/l
2.34
140
819
178
1199
1.65
7.21
1.7
1.7
475.98
437.10
pmol/l
0.73
145
982
239
1741
1.57
6.96
3.0
2.4
—
—
—
0
0
116
704
1.78
6.85
8.7
6.5
105.78
104.22
mmol/l
3.53
116
704
60
295
2.13
6.58
12.0
11.4
—
—
—
0
0
322
2539
1.50
6.34
3.3
2.6
—
—
—
0
0
109
667
1.75
6.24
2.3
1.6
—
—
—
0
0
344
2756
1.49
6.22
6.2
3.9
0.00
0.00
estimate
-0.00
81
490
236
1753
1.52
6.14
4.1
3.4
76.61
102.24
e6/l
0.22
200
1357
340
2726
1.48
6.08
7.9
5.3
0.00
0.00
estimate
-0.00
84
501
230
1708
1.52
5.96
4.1
3.9
7.39
7.40
ph
0.85
69
315
17
45
3.85
5.84
1.4
1.4
0.69
1.04
promille
0.46
11
35
32
126
2.61
5.78
5.9
3.7
1.92
2.73
mmol/l
1.15
24
85
230
1753
1.47
5.10
2.6
2.5
51.02
60.25
u/l
1.86
212
1630
14
28
5.08
4.96
3.1
2.3
67.93
43.17
umol/l
1.90
14
21
301
2426
1.42
4.89
6.2
4.7
34.48
35.51
g/l
2.50
275
2250
489
5402
0.68
4.82
4.7
5.0
2.69
2.71
mmol/l
0.14
441
4946
11
18
6.19
4.61
1.1
1.1
1682.00
1488.50
miu/ml
0.17
11
18
210
1599
1.45
4.60
3.9
3.3
0.55
0.47
e6/l
0.18
179
1217
15
420
0.34
4.44
1.1
1.4
—
—
—
0
0
173
1279
1.47
4.39
5.7
3.8
—
—
—
0
0
253
2009
1.41
4.35
4.8
4.0
125.81
131.69
e6/l
0.03
208
1446
349
2932
1.38
4.25
5.9
6.1
9.95
12.04
umol/l
2.79
328
2772
244
1934
1.40
4.21
3.1
3.2
2.35
2.35
mmol/l
0.28
214
1693
75
464
1.69
4.13
7.2
4.0
—
—
—
0
0
477
5245
0.71
4.00
4.1
4.4
1.40
1.47
mmol/l
3.10
431
4799
21
481
0.42
3.97
1.1
1.5
—
—
—
0
0
35
171
2.10
3.97
1.5
1.4
31.55
25.82
iu/l
0.36
29
141
13
32
4.12
3.92
13.6
15.2
1370.15
1457.66
nmol/l
0.14
13
32
175
1327
1.43
3.84
2.8
2.4
—
—
—
0
0
87
576
1.58
3.68
5.6
4.4
2.22
1.80
mmol/l
0.54
73
464
38
198
1.97
3.65
2.1
2.6
20.26
21.61
s
1.43
31
182
197
1540
1.39
3.60
4.0
3.3
—
—
—
0
0
484
5281
0.73
3.55
4.2
4.4
4.56
4.61
mmol/l
0.54
436
4865
12
31
3.92
3.50
9.3
11.2
664.83
822.10
nmol/l
0.51
12
31
432
3821
1.34
3.47
6.1
4.4
—
—
—
0
0
6
209
0.28
3.39
1.2
1.6
—
—
—
0
0
167
2116
0.72
3.30
1.9
2.1
—
—
—
0
0
25
116
2.20
3.26
4.5
2.7
—
—
—
0
0
39
215
1.86
3.20
11.0
4.5
8.75
8.51
kpa
0.38
39
207
79
531
1.55
3.14
2.4
2.0
384.86
384.96
nmol/l
0.00
71
489
10
283
0.34
3.08
1.4
1.4
—
—
—
0
0
9
22
4.13
2.89
1.3
1.2
—
—
—
0
0
6
9
6.71
2.87
1.0
1.9
18.92
14.21
umol/l
—
6
9
6
9
6.71
2.87
2.3
1.0
—
—
—
0
0
75
510
1.53
2.85
8.6
8.1
—
—
—
0
0
139
1777
0.73
2.83
3.2
2.9
—
—
—
0
0
73
504
1.50
2.60
2.1
2.5
6.04
6.86
ug/l
0.10
61
440
469
5069
0.77
2.58
3.8
4.0
1.39
1.27
mmol/l
2.12
424
4608
6
11
5.49
2.55
1.2
1.4
—
—
—
0
0
111
1444
0.72
2.50
1.7
1.7
1.50
1.37
mmol/l
0.93
90
1210
18
82
2.23
2.49
2.2
2.5
—
—
—
0
0
169
1364
1.32
2.42
1.6
1.5
20.54
20.92
nmol/l
0.09
152
1146
584
5514
1.36
2.37
24.9
14.7
23.95
24.17
mg/l
0.06
506
4347
18
84
2.17
2.36
1.1
1.4
—
—
—
0
0
424
3854
1.26
2.24
4.0
3.9
—
—
—
0
0
12
48
2.53
2.19
1.8
2.3
1.86
3.00
u/field
—
7
20
181
1494
1.29
2.18
6.6
3.5
—
—
—
0
0
13
55
2.39
2.13
1.8
1.5
0.16
0.37
nmol/l
—
8
43
467
5004
0.80
2.06
5.7
5.8
39.83
39.95
mmol/mol
0.10
427
4610
595
5668
1.34
2.00
28.2
17.2
139.71
139.65
mmol/l
0.21
582
5511
140
1131
1.30
1.98
4.1
4.0
1152.25
382.86
ng/l
0.59
105
903
596
5681
1.34
1.97
27.2
17.4
3.95
3.99
mmol/l
3.00
582
5516
135
1087
1.30
1.96
2.8
2.9
2.47
2.45
mmol/l
0.81
122
946
495
5260
0.80
1.95
4.4
4.6
5.96
5.96
mmol/l
0.01
445
4751
66
475
1.43
1.94
2.1
2.6
74.20
70.40
e9/l
0.40
54
368
5
11
4.57
1.94
4.6
1.0
—
—
—
0
0
8
27
2.98
1.94
2.1
1.8
9.50
9.66
mmol/l
—
8
27
9
35
2.59
1.80
1.4
1.4
—
—
—
0
0
166
1388
1.26
1.78
1.4
1.4
—
—
—
0
0
72
948
0.73
1.74
2.2
2.9
0.73
0.80
ug/l
0.26
51
621
17
90
1.91
1.66
7.4
2.5
—
—
—
0
0
42
598
0.68
1.61
1.2
1.3
—
—
—
0
0
8
172
0.46
1.60
1.6
1.6
—
—
—
0
0
60
442
1.39
1.59
8.9
4.7
5.35
5.15
kpa
0.95
60
423
84
654
1.32
1.57
2.1
2.7
1.80
1.78
%
0.06
75
584
35
233
1.53
1.55
1.5
1.9
—
—
—
0
0
49
351
1.43
1.52
1.2
1.2
123.66
166.99
iu/ml
0.38
24
138
168
1432
1.23
1.51
2.6
2.2
3.29
3.14
mg/l
0.29
145
1214
62
464
1.37
1.50
1.4
1.4
—
—
—
0
0
38
543
0.68
1.50
1.5
1.6
—
—
—
0
0
59
438
1.38
1.50
8.9
4.7
7.39
7.40
ph
0.19
15
45
11
215
0.50
1.47
1.0
1.1
—
—
—
0
0
449
4199
1.19
1.46
4.1
3.8
15.27
14.82
pmol/l
2.99
406
3773
6
22
2.74
1.43
1.7
3.0
29.70
27.86
umol/l
—
6
22
145
1228
1.23
1.38
2.0
1.8
2.10
1.21
mg/l
0.71
116
958
453
4257
1.18
1.32
7.5
7.3
83.04
80.52
u/l
0.40
425
3975
57
742
0.75
1.31
1.3
1.2
—
—
—
0
0
5
18
2.79
1.28
1.6
1.6
—
—
—
0
0
12
62
1.95
1.28
2.8
2.7
—
—
—
0
0
255
2294
1.18
1.26
2.0
2.0
93.71
94.19
pmol/l
0.06
137
1152
6
25
2.41
1.24
2.5
2.0
132.82
72.67
ug/l
—
6
25
254
2287
1.17
1.24
2.4
2.3
74.66
77.69
nmol/l
0.94
232
2027
5
19
2.64
1.22
1.2
1.2
—
—
—
0
0
26
173
1.52
1.19
12.3
11.5
—
—
—
0
0
29
415
0.69
1.19
1.2
1.2
—
—
—
0
0
10
50
2.01
1.17
3.3
1.2
—
—
—
0
0
61
476
1.31
1.16
2.1
3.0
66.83
66.27
g/l
0.22
55
429
5
20
2.51
1.15
1.2
1.2
—
—
—
0
0
7
30
2.35
1.12
1.9
4.0
—
—
—
0
0
20
128
1.58
1.09
2.2
2.1
4710.42
4458.20
u/l
—
5
41
5
21
2.39
1.09
2.0
2.3
544.00
486.00
e6/l
—
5
5
5
21
2.39
1.09
7.0
6.4
—
—
—
0
0
70
862
0.79
1.08
1.2
1.3
8.08
11.05
u/ml
0.30
34
312
243
2668
0.86
1.08
6.5
5.6
57.82
57.17
%
0.33
231
2501
13
74
1.77
1.07
1.2
1.3
—
—
—
0
0
10
52
1.94
1.06
1.0
1.2
—
—
—
0
0
30
212
1.43
1.05
2.5
3.6
0.39
0.30
g/l
0.18
15
87
12
67
1.80
1.05
2.3
1.7
32.17
32.54
pg
0.11
12
67
53
672
0.77
1.04
1.2
1.3
—
—
—
0
0
29
402
0.71
1.02
1.3
1.4
—
—
—
0
0
10
53
1.90
1.01
2.9
2.2
1.46
1.23
e9/l
—
10
42
0
29
0.00
0.98
0.0
1.1
—
—
—
0
0
192
1722
1.16
0.97
2.8
3.2
951.58
1488.08
ng/l
2.03
161
1479
22
149
1.49
0.96
1.3
1.4
—
—
—
0
0
54
675
0.78
0.96
2.2
2.2
275.33
135.38
ug/g
0.43
42
527
15
93
1.63
0.94
1.4
1.6
—
—
—
0
0
16
241
0.66
0.89
1.0
1.4
—
10.08
—
0
5
8
43
1.87
0.87
3.1
1.9
39.61
38.49
%
—
8
43
267
2466
1.13
0.87
13.7
9.3
0.00
0.01
e9/l
0.67
228
2013
566
5819
0.86
0.86
11.1
10.3
27.38
25.92
u/l
0.54
545
5601
16
237
0.67
0.83
1.1
1.2
—
—
—
0
0
56
455
1.25
0.82
3.2
3.8
89.63
82.15
ng/l
0.25
48
408
38
295
1.30
0.80
2.7
3.0
4.53
4.56
pmol/l
0.06
33
257
11
66
1.68
0.79
1.2
1.2
—
—
—
0
0
5
98
0.51
0.78
1.0
1.3
—
—
—
0
0
55
450
1.24
0.77
4.2
4.3
1.50
1.00
%
0.44
20
167
50
406
1.25
0.75
4.2
4.4
0.13
0.88
%
0.50
15
120
25
185
1.36
0.73
2.0
2.2
525.52
559.76
ug/l
0.03
19
170
13
84
1.56
0.72
2.3
2.7
—
—
—
0
0
7
41
1.71
0.70
4.3
2.1
—
—
—
0
0
44
539
0.80
0.69
3.9
4.0
—
—
—
0
0
7
43
1.63
0.67
2.7
2.6
—
—
—
0
0
29
371
0.77
0.66
2.2
2.3
13.55
12.79
nmol/l
0.19
24
335
41
501
0.81
0.64
2.7
2.4
28.65
30.85
u/l
0.27
31
417
25
325
0.76
0.64
1.3
1.2
—
—
—
0
0
151
1655
0.89
0.63
3.9
4.9
3.58
2.63
ug/l
0.35
129
1471
13
188
0.69
0.63
1.4
1.2
—
—
—
0
0
61
518
1.19
0.63
2.0
2.4
0.21
0.21
g/l
0.08
55
486
5
30
1.67
0.61
1.4
3.1
1728.00
922.93
u/ml
—
5
30
14
97
1.45
0.59
3.1
3.1
5.93
4.37
e9/l
0.54
14
97
126
1390
0.89
0.59
2.8
2.7
340.20
6421.48
umol/l
5.44
110
1191
8
53
1.52
0.58
2.9
1.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
14
196
0.71
0.58
1.1
1.1
—
—
—
0
0
80
909
0.86
0.58
1.2
1.3
33.61
37.25
iu/ml
0.10
31
291
6
35
1.72
0.57
1.5
3.4
—
—
—
0
0
255
2705
0.91
0.57
6.6
5.9
27.13
27.79
%
0.38
244
2534
61
707
0.85
0.57
1.3
1.4
760.00
512.94
titre
0.25
12
153
248
2632
0.91
0.56
6.6
5.8
2.51
2.88
%
1.79
238
2452
6
37
1.63
0.55
2.3
1.3
21.17
32.60
%
—
6
23
22
168
1.32
0.55
12.4
5.7
1.92
1.45
mg/l
1.17
22
153
39
469
0.82
0.54
1.6
1.5
—
—
—
0
0
97
1082
0.88
0.54
1.7
1.5
2.18
2.39
g/l
0.65
66
633
30
371
0.80
0.54
1.3
1.4
—
—
—
0
0
22
169
1.31
0.53
1.4
1.4
—
—
—
0
0
241
2556
0.91
0.53
6.5
5.8
0.60
0.67
%
1.23
231
2382
35
287
1.23
0.52
4.8
3.9
—
—
—
0
0
59
680
0.86
0.52
1.6
1.6
—
—
—
0
0
9
134
0.67
0.52
1.3
1.3
—
—
—
0
0
6
40
1.50
0.51
2.2
2.3
0.14
0.21
e9/l
—
6
30
6
41
1.47
0.50
2.2
2.2
549.17
543.10
e6/l
—
6
30
23
180
1.29
0.50
1.3
1.5
—
—
—
0
0
25
199
1.27
0.48
1.2
1.2
0.30
2.06
u/ml
—
6
14
39
328
1.20
0.47
1.3
1.4
—
42.19
—
0
17
465
4777
0.92
0.46
26.9
17.4
14.72
15.05
%
0.71
458
4698
17
129
1.33
0.46
1.3
1.8
—
—
—
0
0
11
77
1.44
0.45
2.2
1.8
—
—
—
0
0
602
6111
0.89
0.45
33.9
21.5
130.96
134.48
g/l
6.97
590
6006
14
103
1.37
0.45
4.6
3.4
63.93
58.44
%
0.65
14
103
252
2650
0.92
0.45
6.9
6.1
8.62
8.66
%
0.06
243
2479
49
424
1.17
0.44
4.1
4.4
0.43
0.16
%
0.43
14
139
602
6108
0.90
0.43
33.6
21.4
7.18
6.79
e9/l
4.29
583
5919
602
6108
0.90
0.43
33.7
21.4
4.37
4.47
e12/l
5.37
583
5920
47
406
1.17
0.43
4.1
4.2
1.93
0.67
%
0.97
15
136
5
31
1.62
0.43
1.6
1.3
—
—
—
0
0
602
6107
0.90
0.43
33.5
21.2
30.16
30.27
pg
0.72
588
6005
6
91
0.66
0.42
1.0
1.2
—
—
—
0
0
5
32
1.57
0.42
1.8
1.4
133.40
163.86
mmol/24h
—
5
32
602
6106
0.90
0.42
33.6
21.3
90.75
90.98
fl
0.53
588
6005
602
6105
0.90
0.41
33.6
21.4
258.43
248.26
e9/l
2.90
584
5939
0
16
0.00
0.41
0.0
1.1
—
0.79
—
0
9
0
17
0.00
0.40
0.0
2.6
—
36147.35
—
0
17
5
34
1.47
0.40
5.8
2.6
—
—
—
0
0
52
590
0.87
0.40
3.8
3.8
4.55
29.26
ug/l
1.15
44
493
46
400
1.16
0.40
1.9
2.5
—
—
—
0
0
602
6103
0.90
0.40
33.5
21.5
39.11
39.88
%
2.30
549
5705
23
187
1.24
0.39
1.3
1.5
—
—
—
0
0
23
187
1.24
0.39
1.3
1.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
55
488
1.14
0.37
3.1
3.1
178.81
206.47
ng/l
0.25
48
442
101
930
1.10
0.37
3.6
3.1
3.07
2.09
e6/l
0.43
68
517
188
1781
1.08
0.36
3.7
3.2
56.53
33.66
u/l
0.45
177
1697
5
77
0.65
0.36
1.2
1.1
—
—
—
0
0
13
99
1.32
0.35
1.4
1.4
180.86
261.79
u/ml
—
7
47
422
4112
1.07
0.34
3.8
4.1
14.67
12.51
mm/h
1.76
384
3766
6
86
0.70
0.33
1.2
1.1
—
—
—
0
0
173
1640
1.07
0.33
4.0
3.9
—
—
—
0
0
51
569
0.89
0.32
1.5
1.5
—
—
—
0
0
7
53
1.32
0.31
1.3
1.2
1.66
1.56
nmol/l
—
7
47
17
138
1.24
0.30
1.2
1.3
164.57
233.01
miu/ml
—
7
67
7
54
1.30
0.30
3.1
1.9
—
—
—
0
0
71
651
1.10
0.29
1.5
1.4
—
—
—
0
0
7
57
1.23
0.29
1.6
1.2
—
—
—
0
0
19
158
1.21
0.28
6.3
4.9
—
—
—
0
0
578
5709
1.07
0.27
24.0
13.6
—
—
—
0
0
10
128
0.78
0.27
1.1
1.3
—
57.00
—
0
10
27
310
0.87
0.26
1.6
1.3
—
—
—
0
0
22
188
1.18
0.25
1.3
1.5
—
—
—
0
0
79
846
0.93
0.24
1.7
1.7
—
—
—
0
0
281
2888
0.95
0.23
6.9
5.9
0.18
0.19
e9/l
0.71
256
2542
7
92
0.76
0.22
1.1
1.2
—
—
—
0
0
5
40
1.25
0.22
1.0
1.2
—
—
—
0
0
5
42
1.19
0.21
1.8
1.6
79.60
80.45
umol/l
—
5
42
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
1.87
—
0
10
0
10
0.00
0.21
0.0
2.4
—
1862.60
—
0
10
0
12
0.00
0.21
0.0
2.8
—
—
—
0
0
0
12
0.00
0.21
0.0
1.5
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
5.7
—
7.10
—
0
13
6
48
1.25
0.20
1.5
1.1
—
—
—
0
0
0
14
0.00
0.20
0.0
1.3
—
—
—
0
0
40
365
1.10
0.20
6.7
2.8
3.34
7.52
e9/l
1.50
30
298
12
99
1.22
0.19
1.5
1.4
—
—
—
0
0
92
872
1.06
0.19
2.9
2.4
11.60
12.81
umol/l
0.80
82
807
62
662
0.93
0.19
2.6
2.9
7.20
7.91
umol/l
0.14
47
584
10
81
1.24
0.19
2.4
2.8
—
—
—
0
0
6
53
1.13
0.18
2.0
1.2
3650.67
134691.00
e6/l
—
6
38
456
4621
0.96
0.17
31.0
19.2
332.13
332.33
g/l
0.17
445
4586
177
1714
1.04
0.17
3.3
3.2
7.28
7.41
mmol/l
0.13
153
1435
7
62
1.13
0.17
1.6
4.6
—
—
—
0
0
153
1584
0.96
0.17
3.2
3.2
388.02
251.49
mg/l
0.16
105
1023
5
68
0.73
0.17
1.4
1.1
—
—
—
0
0
161
1663
0.96
0.16
3.8
3.8
13.81
9.09
mg/mmol
0.41
106
1047
21
187
1.13
0.16
1.3
1.5
—
—
—
0
0
24
266
0.90
0.16
1.1
1.1
—
66.78
—
0
9
9
78
1.16
0.15
1.6
1.4
33.29
31.42
g/l
—
9
69
9
79
1.14
0.15
1.1
1.1
—
—
—
0
0
509
5039
1.04
0.15
4.9
4.7
1.97
2.18
mu/l
0.42
464
4571
40
372
1.08
0.14
6.1
3.1
—
—
—
0
0
20
179
1.12
0.14
4.3
3.0
—
—
—
0
0
19
171
1.11
0.12
2.4
4.2
0.98
2.20
ratio
—
5
16
119
1228
0.96
0.12
1.3
1.3
1.01
2.13
u/ml
1.16
43
294
275
2797
0.97
0.12
6.6
5.6
0.04
0.04
e9/l
0.24
248
2423
12
136
0.88
0.11
1.5
1.8
39.08
41.21
nmol/l
0.11
12
130
32
341
0.94
0.10
11.7
4.5
—
—
—
0
0
5
44
1.14
0.10
1.8
2.4
800.40
561.15
ml
—
5
26
5
44
1.14
0.10
1.0
1.3
—
—
—
0
0
11
124
0.89
0.09
3.7
3.1
0.75
0.89
nmol/l
0.74
11
96
6
57
1.05
0.08
1.0
1.3
—
—
nmol/l
—
0
0
5
62
0.81
0.08
1.0
1.1
1.29
1.47
g/l
—
5
54
5
63
0.79
0.08
2.0
1.2
—
—
—
0
0
7
67
1.05
0.08
1.4
1.6
—
—
—
0
0
6
71
0.84
0.07
1.2
1.3
—
—
—
0
0
263
2598
1.02
0.07
7.3
6.3
—
—
—
0
0
7
80
0.87
0.07
1.6
1.1
—
—
—
0
0
7
80
0.87
0.07
1.6
1.1
—
—
—
0
0
235
2323
1.02
0.06
2.9
2.7
122.86
127.18
ug/l
0.10
204
2123
276
2787
0.98
0.06
6.6
5.6
0.59
0.59
e9/l
0.03
248
2407
82
803
1.02
0.05
2.9
2.3
2.25
2.31
g/l
0.46
74
742
15
140
1.07
0.04
1.8
4.6
—
—
—
0
0
283
2848
0.99
0.03
6.6
5.7
1.84
1.95
e9/l
0.85
259
2536
13
139
0.93
0.03
2.1
2.4
112.04
88.53
ug/min
—
8
86
15
141
1.07
0.03
1.0
1.1
—
—
—
0
0
322
3235
0.99
0.02
12.1
8.7
4.34
4.15
e9/l
0.62
296
2825
140
1410
0.99
0.01
8.3
6.3
—
—
—
0
0
38
388
0.98
0.01
1.4
1.6
—
—
—
0
0
28
287
0.97
0.01
13.5
5.1
25.05
24.91
mmol/l
0.09
28
274
346
3469
0.99
0.01
3.3
3.2
54.28
47.82
u/l
0.62
322
3225
76
753
1.01
0.01
3.1
2.4
20.45
22.61
%
0.82
59
645
15
144
1.04
0.00
2.4
2.7
—
—
—
0
0
23
224
1.03
0.00
2.0
2.9
—
—
—
0
0
29
284
1.02
0.00
3.1
2.5
—
—
—
0
0
16
156
1.03
0.00
1.3
1.2
—
—
—
0
0
12
123
0.98
0.00
2.0
1.7
—
—
—
0
0
13
127
1.02
0.00
4.5
4.7
—
—
—
0
0
10
102
0.98
0.00
1.0
1.5
—
—
—
0
0
11
108
1.02
0.00
1.9
3.5
28.74
2617.71
u/ml
0.61
11
103
27
273
0.99
0.00
4.0
2.8
45.46
67.76
u/ml
0.51
27
261
0
9
0.00
0.00
0.0
1.0
—
18.27
—
0
9
0
9
0.00
0.00
0.0
3.7
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.6
—
—
—
0
0
5
54
0.93
-0.00
1.0
1.0
—
—
—
0
0
9
92
0.98
-0.00
1.7
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
4.32
—
0
6
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
5.42
—
0
5
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
6
62
0.97
-0.00
1.5
1.4
—
—
—
0
0
6
66
0.91
-0.00
1.0
1.3
0.65
0.60
nmol/l
—
6
59
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
9
95
0.95
-0.00
3.8
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
9.63
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.2
5.1
10.72
10.98
%
—
5
50
8
86
0.93
-0.00
3.4
3.7
4.88
1.51
%
—
8
78
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
6
63
0.95
-0.00
1.0
1.3
—
—
—
0
0
5
56
0.89
-0.00
2.2
1.4
90.80
58.28
%
—
5
39
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint G6_HCOTHUNS and mortality.

Females

Parameter HR [95% CI] p-value
G6_HCOTHUNS 3.018 [2.63, 3.46] < 0.001
Birth year 0.998 [0.99, 1.01] 0.569

During the follow-up period (1.1.1998 — 31.12.2019), 789 out of 2228 females with G6_HCOTHUNS died.

Males

Parameter HR [95% CI] p-value
G6_HCOTHUNS 3.131 [2.67, 3.68] < 0.001
Birth year 0.983 [0.97, 0.99] < 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 826 out of 2254 males with G6_HCOTHUNS died.

Mortality risk

Mortality risk for people of age

years, who have G6_HCOTHUNS.

N-year risk Females Males
1 0.299% 0.595%
5 2.223% 3.345%
10 5.219% 8.599%
15 10.012% 15.221%
20 16.312% 24.269%

Relationships between endpoints

↥

Index endpoint: G6_HCOTHUNS – Other and unspecified hydrocephalus

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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