No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
566 |
4. Check minimum number of eventsNone |
566 |
5. Include endpointsNone |
566 |
6. Filter based on genotype QC (FinnGen only) |
566 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Anorexia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6577 | 4584 | 1950 |
| Only index persons | 5178 | 3786 | 1392 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.05 |
| Only index persons | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 21.18 | 18.99 | 25.35 |
| Only index persons | 19.50 | 18.42 | 22.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 566 | 450 | 116 |
| Unadjusted period prevalence (%) | 0.13 | 0.15 | 0.05 |
| Median age at first event (years) | 27.72 | 19.85 | 58.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 515
- Matched controls
- 5148
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R63.0
ICD-10 Finland
Anorexia
4834.6
312.6
269
*
3071A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Anorexia nervosa
+∞
137.9
126
*
78400
ICD-8 Finland
Symptoms referable to upper gastro-intestinal tract, Anorexia
+∞
99.2
92
*
F50.0
ICD-10 Finland
Anorexia nervosa
89.1
81.2
89
12
F50.9
ICD-10 Finland
Eating disorder, unspecified
30.4
46.4
62
23
F50.1
ICD-10 Finland
Atypical anorexia nervosa
56.4
43.5
51
10
7830A
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Anorexia
+∞
38.0
36
*
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.5
34.6
96
174
N06AB03
ATC
fluoxetine; oral
4.1
26.1
115
341
N05AH04
ATC
quetiapine; oral
3.5
25.7
142
508
N05AX08
ATC
risperidone; systemic
5.3
25.2
82
178
R53
ICD-10 Finland
Malaise and fatigue
3.1
23.8
160
654
E87.6
ICD-10 Finland
Hypokalaemia
10.0
23.3
47
51
N05AH03
ATC
olanzapine; systemic
5.7
22.9
69
137
N06AX11
ATC
mirtazapine; oral
2.7
22.4
208
1039
F50.2
ICD-10 Finland
Bulimia nervosa
19.5
22.0
33
18
R63.4
ICD-10 Finland
Abnormal weight loss
8.0
21.8
50
68
P86
ICPC
Anorexia nervosa/bulimia
34.1
20.4
26
8
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.5
19.4
192
976
N03AG01
ATC
valproic acid; systemic, rectal
5.2
19.0
61
130
N05BA04
ATC
oxazepam; oral
2.6
18.6
166
791
N03AX09
ATC
lamotrigine; oral
5.1
18.6
61
133
N05AA02
ATC
levomepromazine; systemic
6.3
18.4
50
87
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.3
17.0
93
321
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.0
16.8
109
425
R11
ICD-10 Finland
Nausea and vomiting
3.5
14.8
74
238
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.6
14.8
52
122
P99
ICPC
Psychological disorders other
7.7
14.7
34
47
N05CD07
ATC
temazepam; oral
3.2
14.7
82
287
N06AX16
ATC
venlafaxine; oral
2.8
14.6
107
448
D64.9
ICD-10 Finland
Anaemia, unspecified
3.6
14.3
67
205
N03AX16
ATC
pregabalin; oral
2.4
13.9
139
689
N06AX03
ATC
mianserin; oral
5.6
13.8
40
76
F29
ICD-10 Finland
Unspecified nonorganic psychosis
5.3
13.7
42
85
N06AB04
ATC
citalopram; systemic
2.4
13.7
137
676
30650
ICD-8 Finland
Special symptoms not elsewhere classified, Feeding disturbance
+∞
13.6
13
*
N91.1
ICD-10 Finland
Secondary amenorrhoea
6.7
13.4
34
54
E86
ICD-10 Finland
Volume depletion
8.9
13.4
28
33
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.2
13.2
161
875
N05BA01
ATC
diazepam; systemic, rectal
2.8
13.2
90
359
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
7.5
13.0
30
42
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.3
12.9
48
120
K59.09
ICD-10 Finland
Constipation, unspecified
4.4
12.8
47
116
P29
ICPC
Psychological sympt/compl other
3.8
12.7
54
152
N05AX12
ATC
aripiprazole; systemic
4.6
12.4
43
100
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
7.7
12.4
28
38
N05AH02
ATC
clozapine; systemic
7.5
12.2
28
39
N05CF01
ATC
zopiclone; oral
2.1
11.9
174
1013
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
3.8
11.9
50
140
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.5
11.8
42
100
K59.0
ICD-10 Finland
Constipation
4.1
11.5
45
118
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.9
11.5
73
277
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
11.4
122
618
A03FA02
ATC
cisapride; oral, rectal
3.5
11.3
53
162
N05AN01
ATC
lithium; oral
6.3
11.2
29
48
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.3
11.1
57
187
N06AB05
ATC
paroxetine; oral
3.5
11.1
52
159
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.5
11.1
52
159
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.2
10.8
41
105
AA400
NOMESCO Finland
Electroconvulsive therapy
13.3
10.7
18
14
N05BA06
ATC
lorazepam; systemic, sublingual
4.0
10.7
42
111
N05AF03
ATC
chlorprothixene; systemic
5.8
10.6
29
52
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
17.1
9.9
15
9
A03FA01
ATC
metoclopramide; systemic, rectal
2.1
9.8
121
650
N03AE01
ATC
clonazepam; systemic
3.5
9.8
45
136
P01
ICPC
Feeling anxious/nervous/tense
2.5
9.8
82
365
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
13.7
9.7
16
12
N06AB10
ATC
escitalopram; oral
2.1
9.7
129
716
F50.8
ICD-10 Finland
Other eating disorders
11.7
9.6
17
15
A06AD11
ATC
lactulose; oral
2.5
9.6
78
341
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
8.9
9.4
19
22
A28
ICPC
Limited function/disability NOS
2.5
9.4
77
340
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.6
9.3
31
70
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.9
9.2
22
33
P74
ICPC
Anxiety disorder/anxiety state
4.1
9.2
35
90
SPAT1240
SPAT
Therapeutic discussion
2.4
9.0
77
347
N05AB03
ATC
perphenazine; systemic, rectal
4.3
8.8
32
79
9694A
ICD-9 Finland
Poisoning by psychotropic agents, Benzodiazepine-based tranquillisers
50.9
8.7
10
*
G40.9
ICD-10 Finland
Epilepsy, unspecified
4.9
8.5
27
58
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
8.5
79
368
X78
ICD-10 Finland
Intentional self-harm by sharp object
91.5
8.4
9
*
N06AB06
ATC
sertraline; oral
2.4
8.4
71
318
F60.9
ICD-10 Finland
Personality disorder, unspecified
7.3
8.3
19
27
SPAT1301
SPAT
No procedures
1.9
8.3
161
1015
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
4.1
8.3
31
79
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
3.9
8.2
32
85
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
5.0
8.2
25
52
G03FB06
ATC
medroxyprogesterone and estrogen; systemic (progestogens and estrogens, sequential prep.)
2.8
8.1
51
193
F60.0
ICD-10 Finland
Paranoid personality disorder
33.9
8.1
10
*
Z72.8
ICD-10 Finland
Other problems related to lifestyle
22.4
8.0
11
5
N04AA02
ATC
biperiden; systemic
6.3
7.9
20
33
A04
ICPC
Weakness/tiredness general
2.2
7.9
82
406
N06AA12
ATC
doxepin; systemic
3.6
7.7
33
95
2768A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[HYPOKALAEMIA]
45.7
7.7
9
*
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.4
7.7
67
304
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.3
7.6
71
335
M05BA04
ATC
alendronic acid; oral
2.9
7.6
44
159
R33
ICD-10 Finland
Retention of urine
3.4
7.5
35
108
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.3
7.5
36
114
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
2.3
7.5
71
338
2961E
ICD-9 Finland
Affective psychoses, Manic disorder, recurrent episode[VAKAVA MASENNUSTILA,VAIKEA-ASTEINEN+PSYKOOT PIIRTEI]
81.2
7.4
8
*
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
13.6
7.4
12
9
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
4.0
7.4
28
73
3075B
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Other and unspecified disorders of eating[AHMIMISHÄIRIÖ]
+∞
7.3
7
*
7830C
ICD-9 Finland
NA
+∞
7.3
7
*
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
16.0
7.3
11
7
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.3
7.2
34
107
62600
ICD-8 Finland
Disorders of menstruation, Absent
20.3
7.2
10
5
C07AA05
ATC
propranolol; systemic
1.9
7.1
112
656
F99
ICD-10 Finland
Mental disorder, not otherwise specified
4.6
7.0
23
52
N06AX21
ATC
duloxetine; oral
2.3
7.0
63
291
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
7.0
184
1269
N02AA05
ATC
oxycodone; systemic
2.3
6.9
65
308
N03AF02
ATC
oxcarbazepine; oral
4.1
6.9
25
63
R55
ICD-10 Finland
Syncope and collapse
2.5
6.8
53
225
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.9
6.8
39
140
UJD02
NOMESCO Finland
Gastroscopy
3.4
6.7
30
91
A06AC01
ATC
ispaghula (psylla seeds); oral
1.8
6.6
116
702
F21
ICD-10 Finland
Schizotypal disorder
12.5
6.6
11
9
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
12.5
6.6
11
9
N05AA01
ATC
chlorpromazine; systemic, rectal
8.9
6.6
13
15
F50.3
ICD-10 Finland
Atypical bulimia nervosa
7.0
6.6
15
22
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.3
6.5
31
98
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
6.3
6.5
16
26
R50.9
ICD-10 Finland
Fever, unspecified
2.1
6.5
73
375
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
7.5
6.4
14
19
N06AX26
ATC
vortioxetine; oral
2.9
6.4
37
133
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.7
6.4
190
1345
N06AA04
ATC
clomipramine; systemic
6.1
6.3
16
27
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.9
6.3
100
585
F50
ICD-10 Finland
Eating disorders
27.0
6.2
8
*
7870A
ICD-9 Finland
Symptoms involving digestive system, Nausea and vomiting
27.0
6.2
8
*
G03DB01
ATC
dydrogesterone; oral
1.9
6.2
88
496
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
4.1
6.2
22
55
P76
ICPC
Depressive disorder
2.6
6.1
43
174
188
Kela drug reimbursment
Psychosis requiring demanding treatment
8.7
6.1
12
14
SPAT1307
SPAT
Psychosocial counselling and guidance
2.5
6.1
46
195
F32.8
ICD-10 Finland
Other depressive episodes
5.3
6.1
17
33
N05BA12
ATC
alprazolam; oral
2.3
6.1
56
261
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
10.2
6.1
11
11
A49.9
ICD-10 Finland
Bacterial infection, unspecified
2.5
6.0
46
196
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
144
480
3.68
36.44
8.3
5.9
1.1
1.1
mmol/l
0.00
135
448
217
1079
2.64
26.06
2.6
2.2
2.7
3.0
mg/l
0.93
193
913
287
1660
2.48
24.66
7.0
4.4
35.3
36.3
g/l
1.98
270
1542
117
442
3.08
23.39
2.3
2.0
378.2
377.1
nmol/l
0.02
111
406
267
1544
2.38
22.33
2.2
1.9
96.4
97.1
pmol/l
0.07
156
800
249
1408
2.37
21.79
4.2
3.0
2.3
2.4
mmol/l
0.27
222
1254
142
623
2.71
21.36
5.4
3.4
0.8
0.8
mmol/l
0.11
135
583
311
1980
2.27
20.04
10.1
6.3
1.2
1.2
mmol/l
0.37
278
1658
282
1779
2.17
17.94
9.3
6.1
1.2
1.2
mmol/l
0.70
265
1619
175
917
2.31
17.56
1.8
1.5
21.2
20.7
nmol/l
0.13
154
783
91
353
2.88
17.06
3.2
2.7
0.2
0.2
g/l
0.28
78
331
222
1306
2.15
16.58
3.8
2.4
59.9
56.2
u/l
0.62
207
1204
137
675
2.36
15.64
2.1
1.6
1170.0
1173.3
nmol/l
0.02
123
502
316
2156
2.05
15.54
7.5
5.6
9.5
10.7
umol/l
1.95
302
2033
127
607
2.41
15.52
2.6
2.2
13.2
13.5
umol/l
0.18
116
557
200
1155
2.13
15.45
2.7
2.0
156.6
157.5
u/l
0.01
189
1096
120
560
2.45
15.45
2.5
1.6
1.6
1.4
%
1.95
105
505
117
546
2.44
15.03
2.6
2.2
2.3
2.4
g/l
1.29
105
501
140
714
2.28
14.65
3.4
2.5
2.4
2.4
mmol/l
0.02
118
627
71
264
2.93
14.29
2.0
1.7
—
—
—
0
0
360
2624
2.02
14.16
16.3
8.3
3.8
4.0
e9/l
0.74
323
2288
122
595
2.34
14.13
1.9
1.8
—
—
—
0
0
279
1887
1.94
13.37
3.0
2.3
80.9
75.8
nmol/l
1.84
255
1712
323
2306
1.93
13.04
3.9
2.8
103.3
79.9
ug/l
1.48
311
2145
392
3012
1.98
12.43
6.5
4.2
1076.7
2944.3
e6/l
—
6
43
225
1458
1.90
11.90
4.3
3.0
25.8
29.6
u/l
2.73
214
1394
101
493
2.28
11.52
2.8
2.4
22.3
22.5
%
0.07
90
420
75
325
2.51
11.15
7.3
5.3
2.3
1.8
mmol/l
0.33
59
247
329
2443
1.83
10.94
6.2
4.6
6.4
6.4
mmol/l
0.05
304
2223
416
3328
1.94
10.88
5.2
3.8
12.1
10.3
mm/h
1.69
390
3084
87
408
2.34
10.87
1.8
1.8
—
—
—
0
0
79
362
2.37
10.39
5.2
8.6
1.4
1.1
mmol/l
0.23
69
290
412
3313
1.90
10.25
10.5
6.6
76.8
76.6
u/l
0.02
392
3099
83
403
2.24
9.52
1.8
1.7
—
—
—
0
0
187
1216
1.80
9.30
1.4
1.3
0.6
1.8
u/ml
2.13
60
323
215
1464
1.76
9.10
4.7
2.9
—
—
—
0
0
27
73
3.83
8.99
1.4
1.3
—
—
—
0
0
62
281
2.35
8.33
2.2
2.4
2.7
5.1
ug/l
2.46
57
241
211
1458
1.71
8.31
4.0
3.3
27.3
36.1
ng/l
0.74
135
831
48
201
2.52
7.65
1.6
1.7
—
—
—
0
0
45
185
2.56
7.45
10.4
6.5
24.1
23.9
mmol/l
0.16
39
173
132
823
1.79
7.34
2.1
1.6
439.0
28571861.2
pmol/l
1.05
119
707
54
244
2.34
7.31
1.6
1.4
—
—
—
0
0
62
298
2.21
7.26
3.6
3.9
80.1
76.7
ng/l
0.10
55
264
377
3092
1.66
7.24
4.5
3.0
36.0
37.4
u/l
0.22
359
2916
434
3701
1.74
7.12
5.8
4.1
14.5
14.5
pmol/l
0.03
410
3413
295
2289
1.60
7.01
4.9
3.4
0.0
0.0
estimate
0.50
51
422
78
426
1.96
6.52
16.1
18.1
1.2
1.2
inr
0.10
12
66
14
29
4.92
6.48
1.4
1.2
33285.0
46777.3
e6/l
—
8
15
150
1001
1.68
6.46
5.0
3.5
1.0
1.0
kg/l
0.04
23
144
289
2264
1.56
6.37
4.9
3.3
0.0
0.0
estimate
0.00
53
429
28
98
2.95
6.29
1.6
1.2
—
—
—
0
0
289
2269
1.56
6.27
6.2
4.6
0.0
0.0
estimate
0.50
51
438
29
104
2.89
6.25
2.0
2.2
221.8
245.4
ug/l
0.10
29
92
52
249
2.20
6.15
6.6
4.3
2.3
1.6
mmol/l
0.55
37
179
35
142
2.56
5.98
1.4
2.2
1.4
1.4
g/l
0.04
30
119
40
176
2.37
5.77
1.6
1.5
8.6
10.3
u/l
0.37
32
141
152
1048
1.62
5.67
2.6
2.1
—
—
—
0
0
10
17
5.97
5.64
5.8
6.5
116.8
176.3
umol/l
—
5
7
105
661
1.72
5.54
3.4
2.5
1.3
1.0
e6/l
0.65
63
353
26
94
2.85
5.54
1.8
2.4
—
—
—
0
0
15
38
4.03
5.47
1.2
1.1
—
—
—
0
0
32
130
2.55
5.47
1.3
1.4
302.0
320.2
ug/g
0.22
22
68
72
409
1.87
5.34
2.7
2.4
46.8
31.4
u/l
0.65
62
343
10
18
5.64
5.34
1.4
1.2
—
—
—
0
0
160
1131
1.58
5.34
4.8
2.8
0.5
0.4
e6/l
0.08
123
831
38
178
2.22
4.77
1.6
1.8
7.3
10.7
nmol/l
1.26
30
161
32
141
2.35
4.63
2.0
1.8
—
—
—
0
0
17
57
3.04
4.15
1.2
1.3
—
—
—
0
0
33
156
2.18
4.08
2.1
1.9
—
—
—
0
0
95
631
1.61
4.04
3.6
2.7
4.5
3.4
e6/l
0.42
53
326
492
4539
1.64
3.88
25.0
12.5
139.0
139.6
mmol/l
4.77
487
4406
24
101
2.44
3.86
1.3
1.6
—
—
—
0
0
474
4336
1.57
3.86
6.8
4.8
1.8
2.1
mu/l
0.60
449
4024
102
699
1.56
3.80
4.1
3.2
341.2
222.1
ng/l
0.24
71
459
13
39
3.39
3.78
1.4
1.2
—
—
—
0
0
33
162
2.10
3.73
6.8
4.5
0.7
0.7
%
0.59
33
157
14
45
3.16
3.67
2.7
1.6
91.5
90.6
%
0.24
14
45
13
40
3.30
3.64
1.4
1.2
—
—
—
0
0
45
251
1.86
3.57
12.7
7.7
25.5
24.8
mmol/l
0.54
45
251
492
4561
1.60
3.54
25.3
12.6
3.9
3.9
mmol/l
1.44
486
4416
28
132
2.18
3.51
4.0
2.3
—
—
—
0
0
18
69
2.66
3.50
5.0
2.1
16.5
16.2
%
—
10
32
129
946
1.47
3.48
2.7
3.1
1998.3
1075.7
ng/l
1.37
109
774
513
4809
1.71
3.48
14.3
9.0
22.5
24.4
u/l
2.33
501
4647
158
1207
1.43
3.43
6.3
3.6
0.0
0.0
estimate
0.50
53
430
15
53
2.88
3.38
2.7
1.4
—
—
—
0
0
24
109
2.26
3.30
3.3
8.0
1.4
1.7
%
0.84
24
101
255
2125
1.36
3.27
4.6
3.9
—
—
—
0
0
9
20
4.55
3.12
1.2
1.2
12.4
14.5
u/l
—
9
20
73
485
1.58
3.11
3.5
2.8
3.7
5.6
umol/l
4.73
62
417
8
16
5.05
3.06
1.5
1.1
—
—
—
0
0
34
183
1.91
3.03
2.1
1.7
—
—
—
0
0
21
94
2.28
3.00
4.3
3.9
59.7
57.4
%
0.31
21
94
20
92
2.22
2.70
3.9
3.6
4.3
4.2
e9/l
0.10
20
92
52
331
1.63
2.66
2.4
2.1
23941.9
1808.5
u/l
0.91
13
140
11
38
2.93
2.59
1.7
1.1
2.4
0.1
u/ml
—
5
10
59
390
1.57
2.59
4.4
3.0
—
—
—
0
0
213
1779
1.32
2.52
5.4
3.4
—
—
—
0
0
9
26
3.50
2.49
3.3
1.1
—
—
—
0
0
49
314
1.61
2.45
2.5
2.4
66.7
74.7
ml/min/173m2
0.71
24
123
489
4610
1.45
2.37
23.3
11.5
23.8
20.7
mg/l
1.35
377
3538
19
92
2.10
2.29
1.3
1.4
—
—
—
0
0
16
72
2.26
2.29
1.2
1.1
—
—
—
0
0
42
265
1.63
2.25
2.3
1.6
—
—
—
0
0
125
981
1.35
2.24
4.2
2.6
293.8
6942.2
umol/l
4.80
105
864
24
130
1.88
2.15
2.0
1.7
—
234.3
—
0
7
106
817
1.37
2.13
2.4
2.0
—
—
—
0
0
108
835
1.36
2.13
1.3
1.3
14.1
28.3
iu/ml
2.95
28
266
19
95
2.03
2.13
2.3
1.4
—
—
—
0
0
536
5170
1.69
2.12
33.3
17.1
4.3
4.5
e12/l
16.61
527
5043
25
139
1.84
2.08
1.5
1.6
0.0
0.0
iu/ml
—
8
22
7
20
3.53
2.06
1.7
2.9
1520.3
603.5
u/ml
—
7
20
6
17
3.56
1.84
2.2
2.8
52.4
96.1
ug/l
—
6
17
24
138
1.77
1.82
1.1
1.1
—
—
—
0
0
18
94
1.94
1.82
2.4
1.4
—
—
—
0
0
31
482
0.62
1.82
1.5
1.5
—
—
—
0
0
9
35
2.60
1.80
1.1
1.7
—
—
—
0
0
7
23
3.07
1.80
1.7
1.5
27.0
30.0
umol/l
—
7
23
10
41
2.46
1.76
1.1
1.6
—
—
—
0
0
43
291
1.52
1.76
1.1
1.0
—
—
—
0
0
6
18
3.36
1.75
1.3
1.3
—
—
—
0
0
6
18
3.36
1.75
1.3
1.3
—
—
—
0
0
55
393
1.44
1.73
1.5
1.4
20.7
24.8
iu/l
0.51
50
336
382
3536
1.25
1.68
3.7
3.6
—
—
—
0
0
8
31
2.60
1.66
1.0
1.6
—
—
—
0
0
8
31
2.60
1.66
1.0
1.6
—
—
—
0
0
8
31
2.60
1.66
1.0
1.6
—
—
—
0
0
125
1026
1.28
1.62
2.3
1.8
1.3
1.1
mg/l
0.36
88
758
16
84
1.93
1.61
2.6
1.7
—
—
—
0
0
14
70
2.03
1.60
2.7
1.4
—
—
—
0
0
442
4174
1.27
1.56
18.0
10.2
87.2
87.1
ml/min/173m2
0.02
366
3343
15
78
1.95
1.55
1.7
1.2
—
—
—
0
0
15
78
1.95
1.55
1.7
1.2
—
—
—
0
0
13
64
2.06
1.55
2.1
1.5
—
—
—
0
0
111
903
1.29
1.54
2.5
2.1
—
—
—
0
0
7
27
2.61
1.52
1.1
1.1
207.9
140.6
iu/ml
—
7
27
7
27
2.61
1.52
6.9
2.4
—
—
—
0
0
416
3912
1.24
1.46
5.2
4.8
38.3
38.6
mmol/mol
0.20
387
3678
24
149
1.64
1.43
1.4
1.2
—
—
—
0
0
10
46
2.20
1.40
3.4
1.3
—
—
—
0
0
446
4236
1.25
1.37
4.6
3.9
5.7
5.8
mmol/l
0.02
417
3898
24
151
1.62
1.37
1.4
1.2
—
—
—
0
0
5
17
2.96
1.36
2.4
1.5
—
—
—
0
0
5
17
2.96
1.36
3.2
1.4
—
—
—
0
0
18
105
1.74
1.34
2.1
1.3
—
—
—
0
0
454
4328
1.25
1.30
23.1
12.6
38.4
39.6
%
3.80
327
3414
5
18
2.79
1.28
3.2
1.4
—
—
—
0
0
99
814
1.26
1.27
1.4
1.3
3.3
9.2
u/ml
2.06
33
332
6
25
2.41
1.24
1.3
1.5
—
—
—
0
0
19
116
1.66
1.23
4.1
1.6
498.2
411.2
mg/l
0.41
19
109
10
49
2.06
1.22
1.7
1.2
—
—
—
0
0
5
19
2.65
1.22
1.4
1.2
—
—
—
0
0
8
37
2.18
1.22
2.3
1.3
—
—
—
0
0
22
141
1.58
1.19
1.2
1.3
—
—
—
0
0
34
241
1.44
1.17
1.5
1.4
—
—
—
0
0
44
327
1.37
1.16
7.5
3.7
1.2
1.2
mmol/l
1.53
37
283
70
559
1.29
1.15
2.1
1.8
—
—
—
0
0
29
200
1.47
1.14
4.1
2.8
0.3
0.2
e6/l
0.35
29
194
436
4158
1.21
1.13
3.6
3.4
1.2
1.2
mmol/l
1.34
410
3863
15
88
1.72
1.12
1.9
1.3
—
—
—
0
0
24
160
1.52
1.11
1.3
2.1
—
—
—
0
0
5
21
2.39
1.09
3.2
1.4
—
—
—
0
0
7
32
2.20
1.08
1.6
1.7
—
—
—
0
0
21
138
1.54
1.04
1.4
1.9
1.9
6.0
iu/l
—
8
45
9
47
1.93
1.02
2.3
1.5
—
—
—
0
0
5
23
2.18
0.98
1.0
1.1
—
—
—
0
0
7
37
1.90
0.94
2.0
1.5
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
6
27
2.23
0.93
1.0
1.1
—
—
—
0
0
59
478
1.26
0.89
10.5
6.0
—
—
—
0
0
17
111
1.55
0.88
4.6
1.5
1.5
3.9
e6/l
1.47
17
89
17
111
1.55
0.88
4.6
1.6
76.5
135.9
e6/l
0.28
17
92
18
120
1.52
0.86
1.6
1.4
0.4
0.4
nmol/l
0.02
11
99
6
31
1.95
0.84
2.7
1.4
—
—
—
0
0
6
31
1.95
0.84
1.0
1.3
—
—
—
0
0
8
46
1.75
0.83
1.1
1.4
549.8
392.7
pmol/l
—
8
38
6
32
1.88
0.82
1.0
1.5
—
—
—
0
0
43
339
1.29
0.81
3.7
3.9
31.0
21.9
ug/l
0.19
33
271
20
139
1.45
0.80
1.1
1.2
—
25.6
—
0
7
19
133
1.44
0.74
1.1
1.2
—
3.0
—
0
16
19
134
1.43
0.72
1.1
1.2
—
17.6
—
0
27
15
101
1.50
0.70
1.1
1.2
—
1.2
—
0
6
7
44
1.60
0.65
1.1
1.2
—
—
—
0
0
7
44
1.60
0.65
1.1
1.2
—
—
—
0
0
49
406
1.23
0.64
1.3
1.2
57.8
164.2
iu/ml
3.24
14
166
20
147
1.37
0.62
1.5
1.3
—
—
—
0
0
5
30
1.67
0.61
1.2
1.4
2.6
1.8
mmol/l
—
5
30
447
4344
1.14
0.60
4.1
3.8
4.7
4.8
mmol/l
0.92
422
4075
6
35
1.72
0.58
1.5
1.3
—
—
—
0
0
11
73
1.52
0.56
1.3
1.5
—
—
—
0
0
13
90
1.45
0.56
3.0
1.9
—
—
—
0
0
452
4404
1.13
0.55
4.3
4.2
2.7
2.8
mmol/l
2.27
426
4105
6
38
1.58
0.54
1.8
1.6
—
—
—
0
0
414
4015
1.12
0.54
27.2
14.0
13.7
13.5
%
0.62
408
3950
13
92
1.42
0.51
1.0
1.0
1.6
1.7
u/ml
—
6
45
121
1105
1.12
0.50
1.8
1.6
1.3
1.3
mmol/l
0.14
103
956
7
45
1.56
0.49
1.1
1.2
—
—
—
0
0
7
45
1.56
0.49
1.1
1.2
—
—
—
0
0
7
45
1.56
0.49
1.1
1.2
—
—
—
0
0
14
102
1.38
0.47
1.1
1.1
—
—
—
0
0
7
47
1.50
0.47
2.9
1.5
—
—
—
0
0
443
4323
1.11
0.47
4.0
3.8
1.6
1.5
mmol/l
2.03
416
4038
12
85
1.42
0.47
1.2
1.1
—
—
—
0
0
23
183
1.27
0.45
1.6
1.7
—
—
—
0
0
5
31
1.62
0.43
3.2
3.1
—
—
—
0
0
112
1029
1.11
0.43
4.7
3.9
15.0
10.0
mg/mmol
0.37
83
631
8
56
1.43
0.42
2.6
1.5
—
—
—
0
0
5
32
1.57
0.42
8.8
2.3
0.2
0.2
e9/l
—
5
23
5
33
1.52
0.41
2.2
2.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
8
60
1.34
0.40
1.4
1.3
—
—
—
0
0
5
35
1.43
0.39
8.8
2.1
735.6
510.3
e6/l
—
5
24
5
37
1.35
0.37
1.6
2.6
3.3
147.2
nmol/l
—
5
37
49
433
1.14
0.36
2.1
1.7
—
—
—
0
0
35
301
1.17
0.36
1.1
1.2
—
27.5
—
0
16
6
43
1.40
0.35
1.0
1.6
—
—
—
0
0
127
1190
1.09
0.33
1.9
1.7
—
—
—
0
0
7
54
1.30
0.30
1.1
1.1
—
—
—
0
0
7
55
1.28
0.30
1.3
1.1
—
—
—
0
0
13
103
1.27
0.28
1.2
1.3
—
—
—
0
0
19
161
1.19
0.24
1.4
1.5
—
—
—
0
0
10
126
0.79
0.24
2.8
1.5
—
—
—
0
0
5
38
1.32
0.23
1.4
1.6
—
—
—
0
0
5
41
1.22
0.22
1.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
25
221
1.14
0.20
1.4
1.8
3.1
2.7
mg/l
0.12
17
152
6
52
1.16
0.19
1.5
1.5
—
—
—
0
0
6
53
1.13
0.18
1.8
1.4
—
—
—
0
0
7
61
1.15
0.17
1.1
1.3
0.6
0.5
nmol/l
—
7
55
35
320
1.10
0.17
1.5
1.4
—
—
—
0
0
28
309
0.90
0.17
2.3
2.8
0.5
0.8
ug/l
1.91
23
192
23
205
1.13
0.17
2.6
2.1
—
—
—
0
0
8
70
1.14
0.16
2.0
1.1
—
6619.3
—
0
19
56
527
1.07
0.15
5.0
4.9
2.6
2.5
ug/l
0.05
48
461
29
317
0.91
0.15
2.4
2.4
49.9
37.6
u/ml
0.20
29
301
50
470
1.07
0.14
1.5
1.5
—
—
—
0
0
108
1120
0.96
0.14
1.4
1.5
—
—
—
0
0
20
219
0.91
0.11
1.2
1.3
120.3
261.0
miu/ml
—
8
115
14
125
1.12
0.10
1.5
1.1
0.5
2.7
u/ml
—
7
47
15
135
1.11
0.09
7.3
3.2
3.9
3.4
g/l
0.67
15
130
5
47
1.06
0.09
1.4
1.1
—
—
—
0
0
13
116
1.12
0.09
1.2
1.3
—
—
—
0
0
6
54
1.11
0.09
1.8
1.4
—
—
—
0
0
6
54
1.11
0.09
1.8
1.4
—
—
—
0
0
6
54
1.11
0.09
1.0
1.1
19.6
13.4
u/l
—
6
44
6
55
1.09
0.09
1.8
1.4
—
—
—
0
0
6
55
1.09
0.09
1.8
1.4
—
—
—
0
0
6
55
1.09
0.09
1.8
1.4
—
—
—
0
0
40
416
0.96
0.06
3.8
4.1
19.3
21.5
%
0.63
22
192
12
109
1.10
0.06
2.4
1.2
19.6
2.9
ug/l
0.82
12
94
24
228
1.05
0.05
1.7
1.5
—
—
—
0
0
49
476
1.03
0.04
3.7
3.8
35.9
32.3
%
1.16
38
318
31
321
0.96
0.03
1.5
1.3
—
—
—
0
0
26
270
0.96
0.03
1.6
1.4
—
—
—
0
0
26
270
0.96
0.03
1.5
1.4
—
—
—
0
0
26
270
0.96
0.03
1.6
1.4
—
—
—
0
0
26
269
0.96
0.02
1.5
1.4
—
—
—
0
0
21
217
0.97
0.01
1.5
1.5
—
—
—
0
0
28
285
0.98
0.00
1.6
1.5
—
—
—
0
0
34
337
1.01
0.00
2.2
2.3
—
19.0
—
0
22
0
8
0.00
0.00
0.0
1.8
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
60.3
—
0
5
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
5
54
0.93
0.00
1.0
2.1
7.1
81.5
u/ml
—
5
48
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
0.7
—
0
6
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
9
90
1.00
0.00
1.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint R18_ANOREXIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| R18_ANOREXIA | 2.716 [2.11, 3.49] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 508 out of 2219 females with R18_ANOREXIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| R18_ANOREXIA | 3.85 [2.44, 6.09] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1088 males with R18_ANOREXIA died.
Mortality risk
Mortality risk for people of age
years, who have R18_ANOREXIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.251% | 0.774% |
| 5 | 1.631% | 4.47% |
| 10 | 3.628% | 10.666% |
| 15 | 6.819% | 19.76% |
| 20 | 11.606% | 31.491% |
Relationships between endpoints
↥Index endpoint: R18_ANOREXIA – Anorexia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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