No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
581 |
4. Check minimum number of eventsNone |
581 |
5. Include endpointsNone |
581 |
6. Filter based on genotype QC (FinnGen only) |
559 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Anorexia
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6577 | 4584 | 1950 |
| Only index persons | 5178 | 3786 | 1392 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.11 | 0.13 | 0.05 |
| Only index persons | 0.12 | 0.14 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 21.18 | 18.99 | 25.35 |
| Only index persons | 19.50 | 18.42 | 22.42 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 559 | 443 | 116 |
| Unadjusted period prevalence (%) | 0.14 | 0.16 | 0.05 |
| Median age at first event (years) | 28.03 | 20.12 | 58.25 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 581
- Matched controls
- 5810
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
R63.0
ICD-10 Finland
Anorexia
2234.1
307.7
313
*
F50.0
ICD-10 Finland
Anorexia nervosa
83.2
192.6
103
15
3071A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Anorexia nervosa
+∞
151.9
139
*
78400
ICD-8 Finland
Symptoms referable to upper gastro-intestinal tract, Anorexia
+∞
105.5
98
*
F50.1
ICD-10 Finland
Atypical anorexia nervosa
43.7
97.7
59
15
F50.9
ICD-10 Finland
Eating disorder, unspecified
24.7
96.4
70
32
R63.4
ICD-10 Finland
Abnormal weight loss
9.4
52.6
66
78
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.0
52.1
104
205
E87.6
ICD-10 Finland
Hypokalaemia
8.2
40.1
56
75
7830A
ICD-9 Finland
Symptoms concerning nutrition, metabolism and development, Anorexia
+∞
40.1
38
*
N06AB03
ATC
fluoxetine; oral
3.8
35.7
134
430
N05AH04
ATC
quetiapine; oral
3.3
35.0
179
699
N05AA02
ATC
levomepromazine; systemic
6.5
33.9
58
97
N05AH03
ATC
olanzapine; systemic
4.7
32.9
83
198
N91.1
ICD-10 Finland
Secondary amenorrhoea
8.8
32.5
42
51
N05AX08
ATC
risperidone; systemic
4.1
30.4
92
252
R53
ICD-10 Finland
Malaise and fatigue
2.8
30.4
217
1010
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.4
30.3
134
475
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.5
29.4
116
382
E86
ICD-10 Finland
Volume depletion
10.2
27.9
32
33
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
8.8
27.3
35
42
P86
ICPC
Anorexia nervosa/bulimia
65.3
27.2
31
5
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.9
26.3
61
135
N03AX09
ATC
lamotrigine; oral
4.6
26.2
67
161
F50.2
ICD-10 Finland
Bulimia nervosa
22.5
23.7
34
16
N06AX11
ATC
mirtazapine; oral
2.4
23.6
246
1342
N05BA04
ATC
oxazepam; oral
2.5
23.6
207
1044
K59.09
ICD-10 Finland
Constipation, unspecified
4.3
23.5
64
161
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.8
23.4
56
127
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.8
23.2
76
219
N05BA01
ATC
diazepam; systemic, rectal
3.2
23.0
107
387
R11
ICD-10 Finland
Nausea and vomiting
3.3
22.3
92
309
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.5
22.1
190
945
N06AX16
ATC
venlafaxine; oral
2.8
21.5
128
530
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
4.2
21.3
60
155
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.4
21.1
220
1189
N03AG01
ATC
valproic acid; systemic, rectal
3.9
21.1
67
189
N05CD07
ATC
temazepam; oral
3.3
21.0
91
314
T36
ICD-10 Finland
Poisoning by systemic antibiotics
4.6
20.8
52
122
N05AX12
ATC
aripiprazole; systemic
4.4
20.0
52
126
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
3.1
19.1
87
309
N03AE01
ATC
clonazepam; systemic
4.1
18.8
54
141
D64.9
ICD-10 Finland
Anaemia, unspecified
3.3
18.7
76
252
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
5.1
18.5
40
83
N06AB05
ATC
paroxetine; oral
3.8
18.0
58
165
G03FB06
ATC
medroxyprogesterone and estrogen; systemic
3.6
17.9
63
190
N05BA06
ATC
lorazepam; systemic, sublingual
4.0
17.4
52
140
N06AX03
ATC
mianserin; oral
4.2
17.3
48
122
K59.0
ICD-10 Finland
Constipation
4.0
17.3
51
136
N05AF03
ATC
chlorprothixene; systemic
5.5
17.2
34
65
N06AB04
ATC
citalopram; systemic
2.4
17.2
152
754
F50.8
ICD-10 Finland
Other eating disorders
22.7
17.0
24
11
P99
ICPC
Psychological disorders other
4.9
16.8
38
82
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
16.3
152
769
N05AB03
ATC
perphenazine; systemic, rectal
4.8
16.1
37
81
N03AX16
ATC
[U] pregabalin
2.3
16.0
153
783
30650
ICD-8 Finland
Special symptoms not elsewhere classified, Feeding disturbance
+∞
15.7
15
*
F33.10
ICD-10 Finland
Recurrent depression, moderate episode without somatic syndrome
3.4
15.7
60
191
P29
ICPC
Psychological sympt/compl other
3.0
15.4
73
264
N05AH02
ATC
clozapine; systemic
5.7
15.4
29
53
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
6.5
15.1
25
40
N05CF01
ATC
zopiclone; oral
2.1
14.9
203
1189
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.0
14.8
44
118
F60.30
ICD-10 Finland
Emotionally unstable personality disorder, impulsive
5.3
14.7
30
59
N06AB10
ATC
escitalopram; oral
2.2
14.1
159
864
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.6
13.9
47
138
M81.9
ICD-10 Finland
Osteoporosis, unspecified
4.2
13.8
38
96
N05AN01
ATC
lithium; oral
4.6
13.7
33
75
A04
ICPC
Weakness/tiredness general
2.4
13.6
107
499
A03FA02
ATC
cisapride; oral, rectal
3.2
13.4
56
188
ICB01
NOMESCO Finland
Psychiatric treatment plan, standard
4.0
13.0
37
96
P15
ICPC
Chronic alcohol abuse
5.8
13.0
24
43
ZXY51
NOMESCO Finland
2-person team, doctor-nurse
6.1
12.7
22
37
N06AX26
ATC
vortioxetine; oral
2.9
12.6
64
240
A28
ICPC
Limited function/disability NOS
2.4
12.6
97
448
ZXE06
NOMESCO Finland
Procedure duration 50 to 59 minutes
3.3
12.5
49
158
AA400
NOMESCO Finland
Electroconvulsive therapy
13.6
12.5
21
16
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.0
12.3
58
209
A06AD11
ATC
lactulose; oral
2.4
12.1
88
395
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
4.5
12.1
30
70
F33.00
ICD-10 Finland
Recurrent depression, mild episode without somatic syndrome
4.5
11.8
29
67
N06AB06
ATC
sertraline; oral
2.3
11.8
96
454
SPAT1240
SPAT
Therapeutic discussion
2.4
11.7
88
401
N04AA02
ATC
biperiden; systemic
5.3
11.3
23
45
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.8
11.3
241
1614
ICZ03
NOMESCO Finland
Participation in compiling a psychiatric treatment plan
3.6
11.2
37
107
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.4
11.1
88
410
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
10.8
87
408
N06AX12
ATC
bupropion; oral
2.7
10.7
59
231
F60.3
ICD-10 Finland
Emotionally unstable personality disorder
5.6
10.5
20
37
A03FA01
ATC
metoclopramide; systemic, rectal
2.0
10.4
146
849
SPAT1301
SPAT
No procedures
1.9
10.3
186
1174
R33
ICD-10 Finland
Retention of urine
3.2
10.3
41
134
Z2446
NOMESCO Finland
Social worker
2.7
10.2
57
225
IEY05
NOMESCO Finland
Dedicated profession-specific psychiatric intervention, individual
3.4
10.0
37
115
P01
ICPC
Feeling anxious/nervous/tense
2.1
10.0
106
556
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.9
10.0
30
81
T08
ICPC
Weight loss
5.0
9.9
21
43
N06AX21
ATC
duloxetine; oral
2.2
9.7
84
406
P76
ICPC
Depressive disorder
2.6
9.7
58
237
A06AC01
ATC
ispaghula (psylla seeds); oral
1.9
9.7
152
915
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.7
9.7
53
207
M05BA04
ATC
alendronic acid; oral
2.7
9.7
55
219
Z29
ICPC
Social problem NOS
4.4
9.7
24
56
SPAT1307
SPAT
Psychosocial counselling and guidance
2.6
9.4
57
234
F32.8
ICD-10 Finland
Other depressive episodes
5.3
9.4
19
37
3075B
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Other and unspecified disorders of eating[AHMIMISHÄIRIÖ]
+∞
9.4
9
*
ZXE03
NOMESCO Finland
Procedure duration 20 to 29 minutes
3.0
9.4
42
147
G03DB01
ATC
dydrogesterone; oral
2.1
9.3
102
542
JN4AD
NOMESCO Finland
Body CT examination
2.7
9.2
52
207
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
9.1
226
1556
N05BA12
ATC
alprazolam; oral
2.4
9.0
65
291
N06AA04
ATC
clomipramine; systemic
7.0
8.9
21
31
F61.0
ICD-10 Finland
Mixed personality disorders
4.8
8.9
20
43
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
3.0
8.9
39
135
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.2
8.7
79
389
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
8.4
8.6
18
22
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.0
8.6
110
616
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
2.1
8.5
85
435
E44.0
ICD-10 Finland
Moderate protein-energy malnutrition
91.3
8.4
9
*
2768A
ICD-9 Finland
Disorders of fluid, electrolyte and acid-base balance, Hypopotassaemia[HYPOKALAEMIA]
91.3
8.4
9
*
7830C, ,
ICD-9 Finland
+∞
8.4
8
*
F50.3
ICD-10 Finland
Atypical bulimia nervosa
9.6
8.3
16
17
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.1
8.2
35
119
ZY010
NOMESCO Finland
Hospital outpatient
2.7
8.2
46
182
F41.2
ICD-10 Finland
Mixed anxiety and depressive disorder
2.1
8.2
79
399
AA1AD
NOMESCO Finland
CT of head and brain
1.8
8.2
132
798
F60.9
ICD-10 Finland
Personality disorder, unspecified
6.4
8.1
20
32
F42.2
ICD-10 Finland
Mixed obsessional thoughts and acts
6.4
8.1
20
32
62600
ICD-8 Finland
Disorders of menstruation, Absent
22.4
8.0
11
5
NK6QA
NOMESCO Finland
Measurement of bone density from two or more locations with X-ray
2.7
8.0
45
178
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
3.2
8.0
32
105
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
7.9
7.9
17
22
F34.1
ICD-10 Finland
Dysthymia
3.1
7.9
33
111
N03AF02
ATC
oxcarbazepine; oral
3.4
7.9
28
85
N05AD01
ATC
haloperidol; systemic
3.9
7.9
23
61
F99
ICD-10 Finland
Mental disorder, not otherwise specified
3.9
7.9
23
61
UJD02
NOMESCO Finland
Gastroscopy
3.1
7.9
32
106
N06AG02
ATC
moclobemide; oral
3.2
7.8
31
101
F20.9
ICD-10 Finland
Schizophrenia, unspecified
4.3
7.8
20
48
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
7.8
82
428
UJF32
NOMESCO Finland
Coloscopy
1.8
7.7
128
778
ZXE05
NOMESCO Finland
Procedure duration 40 to 49 minutes
2.8
7.7
39
146
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
4.6
7.7
18
40
UGC12
NOMESCO Finland
Flexible bronchoscopy
2.7
7.7
43
170
SPAT1254
SPAT
Administration of medicine
2.0
7.6
89
482
2961D
ICD-9 Finland
Affective psychoses, Manic disorder, recurrent episode[VAKAVA MASENNUSTILA,VAIKEA-ASTEINEN]
18.6
7.6
11
6
F60.0
ICD-10 Finland
Paranoid personality disorder
18.6
7.6
11
6
IGY99
NOMESCO Finland
Other psychiatric treatment contact
3.5
7.6
26
77
F42.9
ICD-10 Finland
Obsessive-compulsive disorder, unspecified
9.0
7.6
15
17
L28
ICPC
Limited function/disability (L)
2.0
7.6
94
520
2968A
ICD-9 Finland
Affective psychoses, Manic-depressive psychosis, other and unspecified
10.2
7.6
14
14
F33.8
ICD-10 Finland
Other recurrent depressive disorders
10.2
7.6
14
14
F41.8
ICD-10 Finland
Other specified anxiety disorders
3.2
7.5
29
93
WZC00
NOMESCO Finland
Treatment plan or consultation
1.7
7.5
208
1461
P03
ICPC
Feeling depressed
2.1
7.4
74
378
N06AX22
ATC
agomelatine; oral
4.1
7.4
20
50
UKC02
NOMESCO Finland
Cystoscopy
2.1
7.4
70
351
IGY01
NOMESCO Finland
Accelerated psychiatric treatment contact
3.4
7.3
26
79
F21
ICD-10 Finland
Schizotypal disorder
16.0
7.2
11
7
K21.0
ICD-10 Finland
Gastro-oesophageal reflux disease with oesophagitis
2.3
7.2
57
265
F41.1
ICD-10 Finland
Generalized anxiety disorder
2.4
7.2
48
207
K59.1
ICD-10 Finland
Functional diarrhoea
2.7
7.2
38
146
C07AA05
ATC
propranolol; systemic
1.8
7.2
134
843
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
12.2
7.1
12
10
N02AA05
ATC
oxycodone; systemic
2.0
7.1
87
479
3039X
ICD-9 Finland
Alcohol dependence syndrome, Other and unspecified alcohol dependence
8.9
7.1
14
16
N06CA01
ATC
amitriptyline and psycholeptics; systemic
2.2
7.0
60
288
SPAT1260
SPAT
Consultation of another employee
1.9
7.0
101
588
R55
ICD-10 Finland
Syncope and collapse
2.2
7.0
62
303
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.7
7.0
164
1100
RD210, ,
NOMESCO Finland
4.1
6.9
19
48
P80
ICPC
Personality disorder
14.0
6.9
11
8
Z72.8
ICD-10 Finland
Other problems related to lifestyle
14.0
6.9
11
8
F33
ICD-10 Finland
Recurrent depressive disorder
3.4
6.9
24
72
F60.5
ICD-10 Finland
Anankastic personality disorder
6.8
6.9
16
24
TKC20
NOMESCO Finland
Catheterisation of bladder
2.7
6.8
37
144
N30.0
ICD-10 Finland
Acute cystitis
1.8
6.8
106
632
Z76.9
ICD-10 Finland
Person encountering health services in unspecified circumstances
2.2
6.7
60
293
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.7
6.7
174
1194
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
1.7
6.6
159
1069
F42.1
ICD-10 Finland
Predominantly compulsive acts [obsessional rituals]
10.2
6.6
12
12
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.9
6.5
83
463
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
6.5
85
478
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.5
112
687
IBA04
NOMESCO Finland
Extensive initial psychiatric evaluation
3.6
6.5
21
60
F33.11
ICD-10 Finland
Recurrent depression, moderate episode of somatic syndrome
3.4
6.5
23
70
P74
ICPC
Anxiety disorder/anxiety state
2.5
6.4
40
167
P73
ICPC
Affective psychosis
14.5
6.4
10
7
L04AX01
ATC
azathioprine; systemic
3.0
6.4
28
97
SPAT1241
SPAT
Extensive assessment of psychosocial situation
6.7
6.4
15
23
I95.1
ICD-10 Finland
Orthostatic hypotension
3.5
6.3
21
61
F31.8
ICD-10 Finland
Other bipolar affective disorders
3.5
6.3
21
61
XF400
NOMESCO Finland
ECG with 12 standard connections
1.9
6.3
81
452
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.6
6.3
36
144
3018X
ICD-9 Finland
Personality disorders, Other personality disorders[MUU TAI SEKAMUOTOINEN PERSOONALLISUUSHÄIRIÖ]
9.4
6.3
12
13
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.7
6.3
119
749
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.6
6.3
205
1485
E46
ICD-10 Finland
Unspecified protein-energy malnutrition
+∞
6.3
6
*
3075A
ICD-9 Finland
Special symptoms or syndromes not elsewhere classified, Other and unspecified disorders of eating[TARKEMMIN MÄÄRITTELEMÄTÖN SYÖMISHÄIRIÖ]
+∞
6.3
6
*
F50
ICD-10 Finland
Eating disorders
27.0
6.2
8
*
D12
ICPC
Constipation
3.2
6.2
24
77
A02BX02
ATC
sucralfate; oral
3.2
6.2
24
77
2989X
ICD-9 Finland
Other nonorganic psychoses, Unspecified psychosis
7.8
6.1
13
17
SPAT1249
SPAT
Treatment-related counselling outside office
1.6
6.1
221
1637
7890A
ICD-9 Finland
Other symptoms involving abdomen and pelvis, Abdominal pain
2.6
6.1
35
141
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
3.5
6.1
20
58
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
149
506
3.62
36.57
8.1
5.9
1.07
1.07
mmol/l
0.01
139
471
300
1716
2.55
26.86
6.9
4.4
35.15
36.34
g/l
2.58
282
1597
224
1115
2.64
26.85
2.6
2.2
2.74
3.01
mg/l
0.97
197
948
123
451
3.19
26.00
2.3
2.0
389.52
377.65
nmol/l
0.27
117
415
279
1599
2.43
24.13
2.2
1.9
96.63
97.17
pmol/l
0.06
160
833
261
1455
2.44
23.97
4.1
3.0
2.35
2.36
mmol/l
0.41
231
1309
149
645
2.76
23.11
5.2
3.6
0.82
0.82
mmol/l
0.07
143
608
325
2052
2.32
21.78
9.9
6.4
1.22
1.22
mmol/l
0.25
291
1730
186
949
2.41
20.15
1.9
1.5
20.99
20.73
nmol/l
0.08
163
812
295
1843
2.22
19.59
9.2
6.2
1.21
1.22
mmol/l
0.56
279
1684
97
366
2.98
19.18
3.1
2.6
0.21
0.22
g/l
0.42
82
344
230
1339
2.19
17.79
3.7
2.4
59.53
57.29
u/l
0.32
215
1235
103
418
2.78
17.74
3.7
2.9
1.63
1.76
%
0.67
94
372
329
2212
2.12
17.36
7.5
5.7
9.74
10.67
umol/l
1.44
315
2089
210
1205
2.16
16.63
2.6
2.0
152.73
208.46
u/l
0.49
199
1140
143
704
2.37
16.37
2.1
1.6
1169.12
1191.60
nmol/l
0.12
127
525
132
636
2.39
15.82
2.6
2.2
13.03
13.55
umol/l
0.37
121
590
122
568
2.45
15.77
2.5
1.6
1.63
1.37
%
1.95
106
512
146
740
2.30
15.54
3.4
2.5
2.44
2.44
mmol/l
0.03
123
650
374
2703
2.08
15.50
16.0
8.4
3.85
4.00
e9/l
0.67
336
2361
121
570
2.42
15.20
2.6
2.2
2.26
2.41
g/l
1.45
109
523
128
619
2.37
15.16
1.9
1.8
—
—
—
0
0
73
270
2.95
14.83
2.0
1.7
—
—
—
0
0
290
1950
1.97
14.31
3.1
2.3
81.00
75.97
nmol/l
1.86
264
1767
333
2366
1.95
13.79
3.9
2.8
110.52
80.28
ug/l
1.78
320
2201
405
3102
2.01
13.17
6.5
4.2
1076.67
2944.28
e6/l
—
6
43
262
1745
1.91
12.90
11.9
11.0
1.13
1.18
inr
0.61
76
542
233
1497
1.93
12.76
4.3
3.1
27.24
29.45
u/l
0.66
221
1433
341
2517
1.86
11.78
6.2
4.6
6.43
6.45
mmol/l
0.06
316
2295
105
516
2.26
11.77
2.8
2.4
22.53
22.62
%
0.02
94
441
92
429
2.36
11.65
1.8
1.8
—
—
—
0
0
79
344
2.50
11.62
7.0
5.4
2.31
1.77
mmol/l
0.44
68
269
315
2282
1.83
11.43
9.7
5.6
27.84
29.08
%
1.21
299
2140
312
2259
1.82
11.29
9.5
5.4
57.58
56.59
%
0.74
295
2113
427
3413
1.95
11.22
10.4
6.6
77.25
76.83
u/l
0.06
409
3198
83
376
2.41
11.20
5.1
8.5
1.40
1.10
mmol/l
0.23
73
304
429
3438
1.95
11.13
5.2
3.9
11.96
10.40
mm/h
1.40
403
3187
91
443
2.25
10.38
6.2
7.0
103.60
104.29
mmol/l
0.66
91
443
196
1258
1.84
10.30
1.4
1.3
0.60
1.74
u/ml
2.08
63
328
88
424
2.27
10.28
1.8
1.7
—
—
—
0
0
223
1516
1.76
9.52
4.7
3.0
—
—
—
0
0
53
209
2.69
9.51
1.5
1.7
—
—
—
0
0
221
1503
1.76
9.39
4.0
3.3
27.36
62.89
ng/l
0.68
145
871
28
78
3.72
8.94
1.4
1.3
—
—
—
0
0
63
287
2.34
8.35
2.2
2.4
2.68
5.17
ug/l
2.70
58
247
390
3162
1.71
8.26
4.5
3.0
36.66
37.45
u/l
0.12
372
2984
37
133
2.90
7.90
1.3
1.4
272.89
320.91
ug/g
0.84
27
70
138
855
1.81
7.85
2.1
1.6
451.55
27596059.94
pmol/l
1.05
125
732
447
3811
1.75
7.38
5.8
4.1
14.51
14.50
pmol/l
0.05
423
3505
304
2365
1.60
7.10
5.0
3.4
0.00
0.01
estimate
0.50
54
435
32
113
2.94
7.06
1.9
2.2
205.48
257.71
ug/l
0.27
32
100
55
255
2.28
7.01
1.6
1.4
—
—
—
0
0
63
314
2.13
6.73
3.6
4.0
79.50
75.74
ng/l
0.12
56
280
37
146
2.64
6.66
1.4
2.1
1.39
1.39
g/l
0.00
31
123
42
177
2.48
6.62
1.6
1.5
8.21
10.25
u/l
0.48
34
142
299
2343
1.57
6.59
6.2
4.6
0.00
0.00
estimate
0.50
54
450
55
262
2.21
6.58
6.5
4.8
2.19
1.61
mmol/l
0.45
40
189
154
1030
1.67
6.55
5.0
3.5
1.02
1.02
kg/l
0.04
23
149
29
102
2.94
6.46
1.6
1.3
—
—
—
0
0
159
1078
1.65
6.40
2.6
2.1
—
—
—
0
0
298
2344
1.56
6.39
5.0
3.3
0.00
0.00
estimate
-0.00
58
473
137
898
1.69
6.26
4.2
2.4
7.17
7.65
e6/l
0.14
125
800
110
687
1.74
5.97
3.5
2.6
1.25
0.98
e6/l
0.57
65
370
27
98
2.84
5.70
1.7
2.4
—
—
—
0
0
167
1177
1.59
5.65
4.8
2.9
0.48
0.44
e6/l
0.09
129
874
74
418
1.88
5.58
2.7
2.4
47.88
31.35
u/l
0.74
64
350
178
1294
1.54
5.20
5.1
3.0
38.62
108.64
e6/l
0.72
142
973
15
31
4.94
5.15
1.5
1.2
8340.30
1835.33
e6/l
—
10
21
109
716
1.64
4.86
4.2
3.2
325.48
218.86
ng/l
0.23
77
475
33
145
2.35
4.80
2.0
1.8
—
—
—
0
0
14
30
4.76
4.70
1.4
1.2
33285.00
43935.00
e6/l
—
8
16
38
180
2.19
4.65
1.6
1.8
7.02
10.58
nmol/l
1.40
31
166
18
60
3.06
4.43
1.2
1.3
—
—
—
0
0
34
158
2.22
4.37
2.1
1.9
—
—
—
0
0
99
652
1.62
4.35
3.6
2.7
4.39
3.33
e6/l
0.44
54
338
49
263
1.94
4.32
12.1
8.3
25.39
24.77
mmol/l
0.43
49
263
13
29
4.56
4.27
1.8
1.6
1.02
1.28
promille
—
8
22
15
39
3.92
4.22
1.2
1.1
—
—
—
0
0
159
1183
1.47
4.02
4.1
3.0
6.73
7.46
mmol/l
1.20
143
1017
10
18
5.63
3.99
5.8
6.3
116.80
155.00
umol/l
—
5
8
136
982
1.50
3.98
2.8
3.1
2171.49
1067.28
ng/l
1.82
116
807
11
23
4.85
3.88
4.6
2.7
39136.36
35713.26
ug/l
0.52
11
23
507
4690
1.64
3.84
25.5
12.7
3.91
3.94
mmol/l
1.40
501
4542
10
19
5.34
3.84
1.4
1.2
—
—
—
0
0
37
188
2.03
3.82
2.0
1.7
—
—
—
0
0
528
4941
1.75
3.76
14.4
9.0
22.47
24.40
u/l
2.31
516
4773
487
4470
1.55
3.74
6.8
4.8
1.76
2.08
mu/l
0.62
462
4146
265
2186
1.39
3.72
2.9
2.5
—
—
—
0
0
14
46
3.09
3.55
2.7
1.6
91.47
90.69
%
0.23
14
46
163
1246
1.43
3.52
6.4
3.6
0.00
0.00
estimate
0.50
56
443
24
106
2.32
3.50
1.3
1.6
—
—
—
0
0
29
139
2.14
3.49
7.0
5.3
8.73
8.69
kpa
0.04
29
134
29
140
2.13
3.43
3.9
2.3
—
—
—
0
0
18
71
2.58
3.32
5.0
2.1
16.46
16.06
%
—
10
33
25
116
2.21
3.27
3.2
7.8
1.41
1.67
%
0.81
25
107
13
40
3.30
3.15
1.4
1.2
—
—
—
0
0
75
501
1.57
3.11
3.5
2.8
3.75
5.55
umol/l
4.91
64
430
13
41
3.22
3.07
1.4
1.2
—
—
—
0
0
21
95
2.26
2.93
1.3
1.4
—
—
—
0
0
8
17
4.76
2.92
1.5
1.1
—
—
—
0
0
15
58
2.63
2.89
2.7
1.5
—
—
—
0
0
53
334
1.65
2.80
2.4
2.1
23941.90
1787.12
u/l
0.91
13
142
21
97
2.21
2.80
4.3
3.9
59.71
57.66
%
0.27
21
97
221
1836
1.33
2.74
5.4
3.4
—
—
—
0
0
504
4736
1.48
2.67
23.3
11.6
23.99
20.62
mg/l
1.57
391
3635
61
408
1.55
2.54
4.5
3.1
—
—
—
0
0
20
95
2.14
2.51
4.0
3.6
4.33
4.16
e9/l
0.10
20
95
130
1011
1.37
2.47
4.1
2.6
291.35
6893.85
umol/l
5.00
112
900
18
83
2.21
2.43
7.1
2.3
5.04
4.94
kpa
0.28
18
83
551
5302
1.76
2.41
33.5
17.3
260.52
259.62
e9/l
0.12
542
5183
43
268
1.65
2.40
2.3
1.6
—
—
—
0
0
551
5306
1.74
2.34
33.4
17.3
4.28
4.47
e12/l
16.42
541
5176
9
28
3.25
2.31
3.3
1.1
—
—
—
0
0
25
134
1.90
2.30
1.9
1.7
—
234.29
—
0
7
550
5302
1.70
2.21
33.7
17.4
38.56
39.81
%
6.78
523
5046
8
24
3.36
2.18
1.6
1.5
26.25
29.87
umol/l
—
8
24
16
74
2.20
2.16
1.2
1.1
—
—
—
0
0
107
824
1.37
2.15
2.4
2.0
—
—
—
0
0
111
863
1.35
2.10
1.3
1.3
14.12
27.74
iu/ml
2.96
28
285
49
330
1.53
2.01
2.4
2.4
66.67
74.32
ml/min/173m2
0.66
24
129
8
28
2.88
1.87
6.1
2.4
—
—
—
0
0
56
395
1.46
1.86
1.6
1.4
20.35
24.73
iu/l
0.57
51
337
25
145
1.76
1.84
1.5
1.5
0.02
0.04
iu/ml
—
8
23
44
296
1.53
1.83
1.1
1.0
—
—
—
0
0
391
3606
1.26
1.83
3.7
3.6
—
—
—
0
0
431
4023
1.28
1.81
5.3
4.8
38.29
38.60
mmol/mol
0.27
401
3778
16
80
2.03
1.81
1.6
1.2
—
—
—
0
0
16
80
2.03
1.81
1.6
1.2
—
—
—
0
0
7
23
3.07
1.80
1.7
2.7
1520.29
640.57
u/ml
—
7
23
19
102
1.89
1.78
2.3
1.5
—
—
—
0
0
19
102
1.89
1.78
12.6
2.5
24.50
24.79
mmol/l
0.09
19
102
25
147
1.73
1.77
1.1
1.1
—
—
—
0
0
17
88
1.96
1.76
2.5
1.7
—
—
—
0
0
6
18
3.36
1.75
2.2
2.9
52.40
93.37
ug/l
—
6
18
32
486
0.64
1.70
1.5
1.5
—
—
—
0
0
6
19
3.18
1.66
1.3
1.3
—
—
—
0
0
6
19
3.18
1.66
1.3
1.3
—
—
—
0
0
128
1052
1.28
1.63
2.3
1.8
1.65
1.07
mg/l
0.66
89
778
25
151
1.69
1.62
1.4
1.2
—
—
—
0
0
17
91
1.89
1.62
1.9
1.3
—
—
—
0
0
455
4301
1.27
1.56
18.2
10.3
86.80
86.86
ml/min/173m2
0.01
378
3461
25
153
1.66
1.56
1.4
1.2
—
—
—
0
0
112
911
1.28
1.55
2.6
2.1
—
—
—
0
0
460
4356
1.27
1.54
4.7
3.9
5.76
5.75
mmol/l
0.01
430
4005
8
33
2.44
1.54
1.0
1.6
—
—
—
0
0
8
33
2.44
1.54
1.0
1.6
—
—
—
0
0
8
33
2.44
1.54
1.0
1.6
—
—
—
0
0
18
102
1.79
1.46
2.4
1.5
—
—
—
0
0
7
28
2.52
1.45
1.1
1.1
207.86
144.63
iu/ml
—
7
28
49
356
1.41
1.43
3.4
3.9
26.72
20.74
ug/l
0.13
39
288
47
340
1.42
1.41
7.2
3.7
1.21
1.23
mmol/l
1.57
40
294
9
40
2.27
1.40
1.1
1.6
—
—
—
0
0
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
7
29
2.43
1.39
1.0
1.2
—
—
—
0
0
20
120
1.69
1.36
3.9
1.5
485.75
432.07
mg/l
0.23
20
113
14
75
1.89
1.35
2.7
1.5
—
—
—
0
0
10
47
2.15
1.34
1.1
1.5
—
—
—
0
0
13
69
1.90
1.29
2.2
1.6
—
—
—
0
0
13
69
1.90
1.29
2.2
1.6
—
—
—
0
0
449
4270
1.23
1.27
3.7
3.5
1.15
1.22
mmol/l
1.45
421
3961
6
25
2.41
1.24
1.0
1.2
—
—
—
0
0
6
25
2.41
1.24
1.3
1.5
—
—
—
0
0
101
835
1.25
1.24
1.4
1.3
3.21
9.02
u/ml
2.09
34
340
10
49
2.06
1.22
3.4
1.4
—
—
—
0
0
30
205
1.49
1.22
4.0
2.8
0.33
0.20
e6/l
0.33
30
198
22
140
1.59
1.22
1.5
1.8
2.12
5.88
iu/l
—
9
46
5
19
2.65
1.22
3.2
1.4
—
—
—
0
0
5
19
2.65
1.22
2.4
1.5
—
—
—
0
0
8
37
2.18
1.22
2.0
1.5
—
—
—
0
0
13
71
1.85
1.20
2.1
1.5
—
—
—
0
0
18
109
1.67
1.20
2.1
1.3
—
—
—
0
0
71
565
1.29
1.19
2.1
1.8
—
—
—
0
0
8
38
2.12
1.19
2.3
1.3
—
—
—
0
0
23
150
1.56
1.16
1.2
1.3
—
—
—
0
0
5
20
2.51
1.15
1.4
1.2
—
—
—
0
0
5
20
2.51
1.15
3.2
1.4
—
—
—
0
0
10
51
1.98
1.11
1.7
1.2
—
—
—
0
0
19
120
1.60
1.10
1.6
1.4
0.35
0.36
nmol/l
0.02
12
99
62
491
1.29
1.08
10.3
6.1
—
—
—
0
0
34
245
1.41
1.08
1.5
1.4
—
—
—
0
0
13
75
1.75
1.03
1.3
1.5
—
—
—
0
0
7
34
2.07
1.03
1.6
1.6
—
—
—
0
0
9
49
1.85
0.99
2.7
1.6
—
—
—
0
0
9
49
1.85
0.99
2.7
1.6
—
—
—
0
0
5
23
2.18
0.98
3.2
1.4
—
—
—
0
0
24
167
1.46
0.93
1.3
2.0
—
—
—
0
0
6
33
1.83
0.79
2.7
1.4
—
—
—
0
0
6
33
1.83
0.79
2.2
1.4
85.50
73.06
umol/l
—
6
33
6
33
1.83
0.79
7.5
2.2
0.14
0.19
e9/l
—
6
24
6
33
1.83
0.79
1.0
1.4
—
—
—
0
0
6
34
1.77
0.76
1.0
1.5
—
—
—
0
0
9
54
1.68
0.75
2.3
1.5
—
—
—
0
0
21
150
1.42
0.74
1.5
1.3
—
—
—
0
0
460
4460
1.15
0.69
4.1
3.9
4.66
4.75
mmol/l
1.11
434
4183
50
412
1.23
0.68
1.3
1.3
57.79
166.27
iu/ml
3.34
14
169
20
146
1.38
0.64
1.1
1.2
—
25.64
—
0
7
19
138
1.39
0.63
1.1
1.2
—
3.04
—
0
16
439
4254
1.13
0.62
27.0
13.9
14.65
14.53
%
0.18
433
4192
465
4523
1.14
0.61
4.4
4.2
2.69
2.82
mmol/l
2.46
436
4217
19
139
1.38
0.61
1.1
1.2
—
17.61
—
0
27
118
1061
1.14
0.61
4.5
3.7
14.64
9.82
mg/mmol
0.36
85
652
15
106
1.43
0.58
1.1
1.2
—
1.23
—
0
6
6
35
1.72
0.58
1.5
1.3
—
—
—
0
0
6
36
1.67
0.57
7.5
2.1
683.00
499.72
e6/l
—
6
25
456
4439
1.13
0.55
4.0
3.8
1.58
1.53
mmol/l
1.83
427
4144
6
40
1.51
0.51
1.8
1.5
—
—
—
0
0
13
92
1.42
0.51
3.0
1.9
—
—
—
0
0
125
1145
1.12
0.49
1.8
1.6
1.27
1.33
mmol/l
0.18
107
988
7
45
1.56
0.49
1.1
1.2
—
—
—
0
0
7
45
1.56
0.49
1.1
1.2
—
—
—
0
0
13
93
1.41
0.48
1.0
1.0
1.62
1.74
u/ml
—
6
46
7
46
1.53
0.48
1.1
1.2
—
—
—
0
0
7
46
1.53
0.48
1.1
1.2
—
—
—
0
0
7
46
1.53
0.48
1.1
1.2
—
—
—
0
0
11
77
1.44
0.46
1.9
2.4
18.80
72.86
ug/min
—
5
46
14
103
1.37
0.45
1.1
1.1
—
—
—
0
0
14
103
1.37
0.45
1.6
1.3
—
—
—
0
0
23
185
1.25
0.42
1.5
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
13
96
1.36
0.42
1.7
3.7
0.42
0.34
u/ml
—
5
50
5
33
1.52
0.41
1.2
1.4
2.56
1.90
mmol/l
—
5
33
5
33
1.52
0.41
3.2
3.0
—
—
—
0
0
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
16
0.00
0.41
0.0
1.1
—
175.09
—
0
16
50
437
1.16
0.41
2.0
1.7
—
—
—
0
0
8
61
1.32
0.39
1.4
1.3
—
—
—
0
0
5
35
1.43
0.39
2.2
2.1
—
—
—
0
0
12
90
1.34
0.36
1.2
1.1
—
—
—
0
0
6
43
1.40
0.35
1.0
1.6
—
—
—
0
0
129
1212
1.08
0.32
2.0
1.7
—
—
—
0
0
7
53
1.32
0.31
2.9
1.5
—
—
—
0
0
7
55
1.28
0.30
1.3
1.1
—
—
—
0
0
7
56
1.25
0.29
1.1
1.1
—
—
—
0
0
7
57
1.23
0.29
1.7
1.4
—
—
—
0
0
8
63
1.27
0.28
2.6
1.4
—
—
—
0
0
13
104
1.26
0.26
1.0
1.1
0.13
1.28
u/ml
—
6
52
9
72
1.25
0.25
1.9
1.1
—
6304.35
—
0
20
28
318
0.87
0.24
2.3
2.9
0.53
0.76
ug/l
1.88
23
197
5
38
1.32
0.23
1.6
2.7
3.30
143.69
nmol/l
—
5
38
19
162
1.18
0.23
1.4
1.5
—
—
—
0
0
5
39
1.28
0.23
1.4
1.5
—
—
—
0
0
5
41
1.22
0.22
1.0
1.4
—
—
—
0
0
0
11
0.00
0.21
0.0
1.4
—
—
—
0
0
0
10
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
15
127
1.19
0.19
1.5
1.1
0.91
3.13
u/ml
—
9
66
52
482
1.09
0.19
4.1
3.9
36.00
32.32
%
1.36
41
327
6
52
1.16
0.19
1.5
1.5
—
—
—
0
0
7
58
1.21
0.18
1.7
1.3
—
—
—
0
0
7
58
1.21
0.18
1.7
1.3
—
—
—
0
0
7
59
1.19
0.18
1.7
1.3
—
—
—
0
0
7
59
1.19
0.18
1.7
1.3
—
—
—
0
0
7
59
1.19
0.18
1.7
1.3
—
—
—
0
0
14
119
1.18
0.18
1.2
1.3
—
—
—
0
0
16
138
1.16
0.17
7.1
3.2
3.88
3.43
g/l
0.71
16
132
25
224
1.12
0.17
1.4
1.8
3.10
2.76
mg/l
0.10
17
158
13
110
1.19
0.17
2.3
1.2
18.24
2.95
ug/l
0.81
13
95
23
205
1.13
0.17
2.6
2.1
—
—
—
0
0
7
63
1.11
0.17
1.1
1.3
0.64
0.50
nmol/l
—
7
57
35
323
1.09
0.15
1.5
1.4
—
—
—
0
0
40
427
0.93
0.13
3.8
4.1
19.32
21.49
%
0.61
22
196
20
221
0.90
0.13
1.2
1.3
120.32
260.60
miu/ml
—
8
116
57
541
1.06
0.13
5.0
4.8
2.60
2.51
ug/l
0.04
49
472
11
127
0.86
0.12
2.6
1.5
—
—
—
0
0
12
104
1.16
0.12
1.2
1.1
—
12.50
—
0
9
5
47
1.06
0.09
1.0
1.1
—
—
—
0
0
6
56
1.07
0.08
1.0
1.1
19.55
13.76
u/l
—
6
46
111
1135
0.97
0.07
1.4
1.5
—
—
—
0
0
24
229
1.05
0.04
1.7
1.5
—
—
—
0
0
26
271
0.96
0.04
1.5
1.4
—
—
—
0
0
26
271
0.96
0.04
1.6
1.4
—
—
—
0
0
26
271
0.96
0.04
1.6
1.4
—
—
—
0
0
26
270
0.96
0.03
1.5
1.4
—
—
—
0
0
21
218
0.96
0.02
1.5
1.5
—
—
—
0
0
48
471
1.02
0.02
1.5
1.5
—
—
—
0
0
28
286
0.98
0.00
1.6
1.5
—
—
—
0
0
33
326
1.01
0.00
1.5
1.3
—
—
—
0
0
32
323
0.99
0.00
2.3
2.4
54.96
37.43
u/ml
0.33
32
307
5
49
1.02
0.00
1.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
50
1.00
-0.00
1.4
1.2
—
—
—
0
0
5
56
0.89
-0.00
1.0
2.1
7.14
72.41
u/ml
—
5
56
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
0.71
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
60.30
—
0
5
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
5
51
0.98
-0.00
1.0
1.1
—
—
—
0
0
9
91
0.99
-0.00
1.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint R18_ANOREXIA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| R18_ANOREXIA | 2.716 [2.11, 3.49] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.099 |
During the follow-up period (1.1.1998 — 31.12.2019), 508 out of 2219 females with R18_ANOREXIA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| R18_ANOREXIA | 3.85 [2.44, 6.09] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.008 |
During the follow-up period (1.1.1998 — 31.12.2019), 358 out of 1088 males with R18_ANOREXIA died.
Mortality risk
Mortality risk for people of age
years, who have R18_ANOREXIA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.251% | 0.774% |
| 5 | 1.631% | 4.47% |
| 10 | 3.628% | 10.666% |
| 15 | 6.819% | 19.76% |
| 20 | 11.606% | 31.491% |
Relationships between endpoints
↥Index endpoint: R18_ANOREXIA – Anorexia
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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