Other protozoal intestinal diseases

AB1_OTHER_PROTOZOAL

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 A07
  • Hospital discharge: ICD-9 007.
  • Hospital discharge: ICD-8 00[7]
  • Cause of death: ICD-10 A07
  • Cause of death: ICD-9 007.
  • Cause of death: ICD-8 00[7]

2 out of 7 registries used, show all original rules.

521

4. Check minimum number of events

None

521

5. Include endpoints

None

521

6. Filter based on genotype QC (FinnGen only)

521

Control definitions (FinnGen only)

Control exclude
AB1_INTESTINAL_INFECTIONS

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF5

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 4130 2179 1912
Only index persons 3443 1892 1551
Unadjusted period prevalence (%)
Whole population 0.06 0.06 0.05
Only index persons 0.06 0.07 0.06
Median age at first event (years)
Whole population 32.48 34.90 29.57
Only index persons 34.41 35.94 32.55

-FinnGen-

Key figures

All Female Male
Number of individuals 521 327 194
Unadjusted period prevalence (%) 0.10 0.11 0.09
Median age at first event (years) 44.84 42.69 48.47

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
452
Matched controls
4520
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
A07.8
ICD-10 Finland
Other specified protozoal intestinal diseases
+∞
199.1
176
*
A07.1
ICD-10 Finland
Giardiasis [lambliasis]
+∞
115.7
106
*
P01AB01
ATC
metronidazole; oral, rectal
6.2
70.4
307
1155
A07.9
ICD-10 Finland
Protozoal intestinal disease, unspecified
+∞
69.6
65
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
8.6
54.5
130
202
00710
ICD-8 Finland
Other protozoal intestinal diseases, Giardiasis
+∞
47.8
45
*
A07.2
ICD-10 Finland
Cryptosporidiosis
+∞
30.6
29
*
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.7
17.3
145
671
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.4
17.2
195
1070
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
46.7
15.2
18
*
A02BC05
ATC
esomeprazole; systemic
2.3
15.0
195
1122
K59.1
ICD-10 Finland
Functional diarrhoea
5.8
14.8
42
78
D11
ICPC
Diarrhoea
3.2
13.8
80
287
UJF32
NOMESCO Finland
Coloscopy
2.5
13.3
117
546
K58.0
ICD-10 Finland
Irritable bowel syndrome with diarrhoea
4.5
13.1
47
114
00799
ICD-8 Finland
Other protozoal intestinal diseases, Other and unspecified
+∞
12.6
12
*
UJF30
NOMESCO Finland
Ileoscopy through colon
3.5
12.5
61
194
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.8
10.6
71
280
0071A
ICD-9 Finland
Other protozoal intestinal diseases, Giardiasis
+∞
10.5
10
*
K58.9
ICD-10 Finland
Irritable bowel syndrome without diarrhoea
4.8
9.8
32
71
A04.9
ICD-10 Finland
Bacterial intestinal infection, unspecified
102.1
9.4
10
*
00920
ICD-8 Finland
Diarrhoeal disease, Gastroenteritis (acuta) (infectiosa)
+∞
9.4
9
*
R53
ICD-10 Finland
Malaise and fatigue
2.3
9.2
96
478
Z71.2
ICD-10 Finland
Person consulting for explanation of investigation findings
2.1
9.1
116
634
K52.9
ICD-10 Finland
Noninfective gastroenteritis and colitis, unspecified
4.8
8.8
28
61
A06AC01
ATC
ispaghula (psylla seeds); oral
2.1
8.4
104
561
0093A
ICD-9 Finland
Ill-defined intestinal infections, Diarrhoea of presumed infectious origin
+∞
8.4
8
*
A06
ICD-10 Finland
Amoebiasis
+∞
8.4
8
*
E0000UV
ATC
NA
1.8
8.3
183
1221
D01
ICPC
Abdominal pain/cramps general
2.5
8.2
65
284
H04.10
ICD-10 Finland
Dry eye syndrome
2.7
7.6
51
200
A04
ICPC
Weakness/tiredness general
2.4
7.5
65
296
K21.9
ICD-10 Finland
Gastro-oesophageal reflux disease without oesophagitis
2.7
7.4
50
197
A06.9
ICD-10 Finland
Amoebiasis, unspecified
+∞
7.3
7
*
A06.8
ICD-10 Finland
Amoebic infection of other sites
+∞
7.3
7
*
K57.3
ICD-10 Finland
Diverticular disease of large intestine without perforation or abscess
2.3
6.9
64
300
R07.4
ICD-10 Finland
Chest pain, unspecified
1.9
6.9
107
625
Z03
ICD-10 Finland
Medical observation and evaluation for suspected diseases and conditions, ruled out
2.8
6.8
43
163
A02BA02
ATC
ranitidine; systemic
2.1
6.8
78
403
J01MA06
ATC
norfloxacin; oral
2.3
6.7
65
312
Z71.8
ICD-10 Finland
Other specified counselling
1.9
6.7
114
689
C10AC01
ATC
colestyramine; oral
5.3
6.7
19
37
J02AC01
ATC
fluconazole; systemic
1.7
6.7
180
1257
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.1
6.7
75
384
A02BC01
ATC
omeprazole; systemic
1.8
6.5
114
698
A06AD11
ATC
lactulose; oral
2.4
6.4
54
245
00000
ICD-8 Finland
NA
+∞
6.3
6
*
0078A
ICD-9 Finland
Other protozoal intestinal diseases, Other specified protozoal intestinal diseases[CRYPTOSPORIDIOSIS]
+∞
6.3
6
*
A07.0
ICD-10 Finland
Balantidiasis
+∞
6.3
6
*
K30
ICD-10 Finland
Functional dyspepsia
2.4
6.1
51
229
N02CC04
ATC
rizatriptan; oral
3.0
6.0
32
111

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
273
131
42.68
307.65
4.3
1.6
—
—
—
0
0
204
527
5.72
78.75
2.4
2.4
76.7
98.4
ug/g
1.06
168
407
80
114
8.11
54.95
1.4
1.2
—
—
—
0
0
103
205
6.02
51.32
1.5
1.2
—
—
—
0
0
138
420
4.11
40.51
1.3
1.3
—
—
—
0
0
223
996
3.17
35.35
1.5
1.3
2.8
2.1
u/ml
0.15
35
252
270
1359
3.05
34.41
4.9
6.2
—
—
—
0
0
56
94
6.55
32.71
1.6
1.3
303.6
310.1
ug/g
0.07
40
47
203
916
2.99
30.80
1.7
1.4
2.1
2.3
g/l
0.89
102
569
133
484
3.35
29.02
1.3
1.2
—
—
—
0
0
109
361
3.55
27.49
1.2
1.2
—
—
—
0
0
345
2162
2.76
26.46
5.8
5.9
2.1
2.0
e9/l
0.25
286
1923
336
2092
2.71
25.86
5.9
5.9
0.5
0.6
e9/l
0.44
269
1823
326
2009
2.66
25.47
5.9
5.8
53.9
56.7
%
4.24
310
1893
314
1901
2.64
25.44
6.1
6.1
0.7
0.7
%
1.40
295
1779
328
2031
2.66
25.32
6.2
6.0
31.0
28.9
%
3.20
312
1907
335
2103
2.66
25.01
5.9
5.9
0.0
0.0
e9/l
0.32
269
1834
318
1960
2.60
24.45
6.2
6.0
3.2
2.8
%
1.36
300
1836
319
1970
2.60
24.42
6.4
6.2
8.5
8.4
%
0.47
300
1856
339
2180
2.59
23.42
6.0
6.2
0.2
0.2
e9/l
0.57
280
1930
101
355
3.29
22.93
1.9
2.3
29.6
34.9
u/l
0.71
91
308
359
2397
2.60
22.50
7.6
9.0
3.6
4.0
e9/l
3.27
292
2102
291
1874
2.25
18.17
8.6
9.1
0.0
0.0
e9/l
0.30
205
1522
185
999
2.32
17.57
2.4
1.9
—
—
—
0
0
408
3071
2.51
17.03
7.8
6.8
71.3
78.9
u/l
2.76
388
2867
252
1572
2.17
16.54
4.4
4.5
36.5
36.2
g/l
0.39
236
1479
185
1020
2.26
16.54
5.6
6.7
—
—
—
0
0
74
262
3.13
16.36
1.5
1.2
—
—
—
0
0
187
1047
2.23
16.01
2.5
2.8
—
—
—
0
0
238
1480
2.12
15.46
2.2
1.8
95.7
95.5
pmol/l
0.02
129
787
230
1417
2.12
15.26
3.4
3.4
23.3
69.4
e6/l
2.99
140
942
186
1065
2.16
14.85
2.9
2.8
0.2
0.4
e6/l
1.35
124
774
64
236
2.95
13.11
1.2
1.2
—
147.0
titre
—
0
8
97
455
2.39
12.26
2.4
2.8
7.0
6.7
umol/l
0.08
80
395
284
1992
1.94
12.20
5.9
6.0
11.5
10.8
umol/l
0.64
269
1889
188
1167
1.96
11.45
2.9
3.0
43.1
64.4
e6/l
0.50
129
863
387
3090
1.98
10.45
4.5
3.8
8.3
10.8
mm/h
4.65
368
2854
119
657
2.05
9.92
2.8
2.7
2.4
2.4
mmol/l
1.73
100
580
267
1938
1.77
9.35
3.9
2.8
80.7
101.3
ug/l
1.86
250
1809
13
17
7.82
9.31
1.2
1.2
—
—
—
0
0
155
957
1.88
9.26
2.8
2.1
2.5
3.0
mg/l
1.67
137
814
25
63
4.12
9.15
2.3
1.5
1.0
0.6
g/l
0.78
20
48
131
772
1.93
8.99
2.1
2.3
6.1
6.7
e6/l
0.13
109
667
171
1099
1.83
8.95
3.2
3.5
7.4
7.4
ph
0.66
23
197
47
181
2.76
8.86
2.4
2.4
—
—
—
0
0
231
1634
1.74
8.65
2.1
2.0
—
—
—
0
0
480
4257
2.62
8.52
15.2
11.7
19.9
21.7
mg/l
0.62
362
3267
191
1299
1.74
8.09
2.7
2.9
2.3
2.4
mmol/l
0.25
168
1149
358
2894
1.76
8.02
5.0
3.8
—
—
—
0
0
104
594
1.94
7.73
2.6
2.2
14.8
13.9
umol/l
0.41
98
548
67
325
2.22
7.71
2.9
2.6
11.1
10.1
g/l
1.18
56
299
107
620
1.91
7.62
2.7
2.8
1.2
2.4
e6/l
2.67
47
340
428
3687
1.90
7.31
17.5
14.4
13.3
13.5
%
2.05
422
3629
458
4042
2.10
7.22
16.1
12.8
40.6
40.1
%
1.22
384
3129
18
43
4.30
7.06
1.1
1.0
—
—
—
0
0
248
1857
1.64
7.06
5.4
6.7
1.2
1.2
mmol/l
0.08
221
1578
135
860
1.77
7.04
1.5
1.5
22.7
21.4
nmol/l
0.50
124
742
95
544
1.91
6.97
2.6
2.1
2.3
2.4
g/l
0.74
87
500
88
501
1.91
6.56
2.8
2.2
26.0
23.2
%
0.71
80
436
118
738
1.77
6.50
2.8
2.6
554.1
564.0
mosm/kgh2o
0.17
91
622
141
928
1.71
6.49
3.2
3.3
—
—
—
0
0
227
1691
1.61
6.42
4.4
6.1
1.2
1.2
mmol/l
0.19
216
1541
445
3928
1.91
6.41
5.4
4.5
1.7
2.1
mu/l
0.75
423
3626
24
77
3.22
6.24
1.1
1.2
—
—
—
0
0
17
43
4.05
6.21
1.5
1.3
2.4
2.7
g/l
0.24
12
31
17
43
4.05
6.21
1.5
1.3
0.3
0.4
g/l
0.33
12
30
388
3306
1.68
6.15
4.4
3.8
14.4
14.6
pmol/l
0.75
360
3032
17
45
3.87
5.85
1.6
1.3
—
—
—
0
0
137
917
1.67
5.85
1.8
1.9
1.6
1.1
mg/l
0.60
100
697
470
4264
2.04
5.68
15.2
13.1
139.5
139.7
mmol/l
1.11
464
4139
333
2773
1.56
5.42
3.6
3.4
—
—
—
0
0
470
4280
2.00
5.37
15.6
13.2
3.9
3.9
mmol/l
7.61
464
4147
53
272
2.06
5.29
1.8
1.7
1.2
1.4
g/l
0.67
47
254
20
64
3.21
5.24
1.2
1.1
—
—
—
0
0
62
339
1.94
5.19
1.4
1.5
—
—
—
0
0
106
687
1.68
5.06
3.3
3.6
1404.6
364.4
ng/l
0.37
73
489
10
19
5.35
5.06
2.4
2.5
—
—
—
0
0
34
152
2.32
4.77
1.9
1.6
—
—
—
0
0
159
1193
1.48
3.93
3.0
2.3
56.0
57.7
u/l
0.24
149
1107
11
29
3.85
3.82
1.3
1.2
0.1
1.4
u/ml
—
6
11
107
745
1.55
3.75
1.2
1.3
31.1
35.9
iu/ml
0.17
23
236
54
315
1.80
3.73
1.7
1.4
—
—
—
0
0
11
30
3.72
3.65
2.5
2.5
—
—
—
0
0
22
93
2.43
3.53
1.2
1.4
245.3
240.8
u/ml
0.02
13
51
48
277
1.81
3.44
1.2
1.2
210.4
159.0
u/ml
0.35
41
249
246
2048
1.38
3.28
5.5
4.5
0.0
0.0
estimate
0.50
42
398
23
103
2.29
3.27
2.9
2.8
—
—
—
0
0
29
144
2.07
3.22
1.5
2.5
1.2
1.3
g/l
0.32
23
126
247
2069
1.37
3.12
3.8
3.3
0.0
0.0
estimate
0.50
41
384
141
1075
1.43
3.12
1.6
1.6
1.1
1.4
mmol/l
4.81
118
911
62
396
1.64
3.12
1.4
1.4
—
—
—
0
0
101
723
1.49
3.09
1.2
1.3
5.5
11.5
u/ml
0.71
33
272
56
349
1.68
3.09
3.1
2.4
0.2
0.2
g/l
0.34
51
331
32
168
1.96
3.07
1.2
1.4
—
—
—
0
0
165
1297
1.40
3.06
2.2
2.2
—
—
—
0
0
243
2038
1.36
3.01
3.8
3.2
0.0
0.0
estimate
0.00
38
392
85
591
1.52
2.99
1.4
1.4
378.7
408.6
titre
0.10
15
116
60
385
1.63
2.97
2.1
3.2
1.5
1.7
%
2.08
51
353
44
263
1.74
2.83
3.1
3.3
4.5
4.6
pmol/l
0.34
35
231
11
36
3.10
2.82
1.0
1.1
—
—
—
0
0
8
18
4.50
2.80
1.0
1.2
166.9
147.7
nmol/l
—
8
18
88
626
1.49
2.78
1.9
1.7
1072.4
1169.0
nmol/l
0.47
62
477
70
475
1.55
2.75
1.4
1.4
—
—
—
0
0
16
66
2.47
2.73
1.2
1.0
—
—
—
0
0
266
2290
1.33
2.66
4.1
4.6
6.2
6.6
mmol/l
2.36
249
2094
20
95
2.15
2.52
1.1
1.3
—
—
—
0
0
77
544
1.49
2.52
2.1
1.5
—
—
—
0
0
8
21
3.85
2.47
1.4
1.2
20.8
23.4
umol/l
—
8
21
60
404
1.55
2.45
1.8
2.0
374.6
371.8
nmol/l
0.04
54
378
9
27
3.37
2.40
3.2
1.6
—
—
—
0
0
7
17
4.16
2.36
1.1
1.2
—
—
—
0
0
16
72
2.26
2.30
1.4
1.1
—
—
—
0
0
78
565
1.45
2.26
1.7
2.4
30.3
29.5
s
0.85
78
554
229
1965
1.30
2.22
3.6
3.9
—
—
—
0
0
45
291
1.60
2.20
1.9
2.5
3.9
4.0
e9/l
0.12
38
235
15
67
2.28
2.19
2.3
1.7
—
—
—
0
0
19
94
2.06
2.18
1.3
1.6
—
—
—
0
0
118
926
1.35
2.15
4.1
3.9
—
—
—
0
0
50
335
1.54
2.11
1.1
1.2
137.8
166.7
iu/ml
0.14
11
148
11
43
2.59
2.11
1.1
1.1
—
—
—
0
0
14
63
2.26
2.02
2.4
2.5
17.3
16.2
%
—
8
36
8
26
3.11
2.02
1.0
1.2
—
—
—
0
0
474
4529
1.52
2.00
11.8
9.3
24.4
26.0
u/l
1.74
467
4377
15
70
2.18
2.00
4.1
2.7
2.5
2.8
mmol/l
—
8
41
17
84
2.06
1.97
1.2
2.1
—
—
—
0
0
7
21
3.36
1.97
1.4
1.1
—
—
—
0
0
5
11
4.58
1.94
1.2
2.9
—
—
—
0
0
49
335
1.51
1.90
2.8
4.4
3.3
20.3
ug/l
0.74
34
275
135
1099
1.31
1.90
2.3
2.0
130.4
272.7
u/l
1.52
126
1029
5
12
4.20
1.82
1.0
1.5
—
—
—
0
0
15
73
2.09
1.82
2.8
2.9
—
—
—
0
0
18
95
1.93
1.77
1.1
1.1
—
—
—
0
0
26
155
1.71
1.76
1.2
1.3
—
—
—
0
0
32
204
1.61
1.70
1.2
1.1
—
—
—
0
0
62
456
1.41
1.68
1.8
1.5
—
—
—
0
0
470
4520
1.41
1.53
12.7
10.8
—
—
—
0
0
13
65
2.03
1.50
1.2
1.2
—
—
—
0
0
7
28
2.52
1.45
1.7
1.3
—
—
—
0
0
5
16
3.14
1.44
1.0
1.0
—
—
—
0
0
5
16
3.14
1.44
1.0
1.0
—
—
—
0
0
6
22
2.75
1.44
1.0
1.4
—
—
—
0
0
9
39
2.33
1.43
3.4
3.3
—
—
—
0
0
10
46
2.20
1.40
1.0
2.8
—
—
—
0
0
17
96
1.80
1.40
1.1
1.1
1.6
0.7
u/ml
0.53
11
47
38
531
0.69
1.38
1.3
1.3
—
—
—
0
0
6
23
2.63
1.37
1.2
1.2
—
—
—
0
0
38
266
1.46
1.36
1.9
1.4
17.4
23.3
iu/l
0.72
31
219
137
1596
0.81
1.35
2.8
2.6
—
—
—
0
0
0
37
0.00
1.35
0.0
3.5
—
19.0
—
0
26
132
1117
1.24
1.34
2.9
2.7
—
—
—
0
0
20
121
1.68
1.32
1.9
2.7
—
—
—
0
0
40
285
1.44
1.32
2.1
3.1
60.0
71.0
e9/l
1.57
28
221
160
1387
1.22
1.29
3.6
3.1
23.4
42.8
ng/l
1.67
87
869
13
69
1.91
1.29
1.2
1.3
0.6
0.5
nmol/l
0.38
13
64
15
84
1.81
1.28
4.1
2.7
7.4
7.4
ph
0.15
15
68
24
154
1.59
1.28
1.6
3.6
0.1
0.2
g/l
0.95
11
68
150
1294
1.22
1.27
1.6
1.5
—
—
—
0
0
22
139
1.61
1.25
1.4
2.1
—
—
—
0
0
164
1430
1.21
1.25
9.8
7.8
1.2
1.2
inr
0.35
47
436
42
308
1.40
1.20
4.4
9.3
—
—
—
0
0
98
813
1.25
1.19
1.9
1.6
—
—
—
0
0
8
38
2.12
1.19
1.0
2.9
—
—
—
0
0
0
33
0.00
1.16
0.0
14.2
—
915.9
—
0
33
0
33
0.00
1.16
0.0
18.6
—
1659.2
—
0
33
19
118
1.63
1.16
1.2
1.3
—
—
—
0
0
15
87
1.75
1.16
2.5
2.0
—
—
—
0
0
5
20
2.51
1.15
1.2
1.1
—
—
—
0
0
5
20
2.51
1.15
1.0
1.5
—
—
—
0
0
65
517
1.29
1.11
1.3
1.2
—
—
—
0
0
423
4050
1.24
1.11
4.4
4.1
5.7
5.8
mmol/l
2.28
386
3731
21
136
1.57
1.10
1.5
1.8
0.8
3.4
ug/l
0.68
16
123
37
273
1.38
1.04
1.5
1.6
—
—
—
0
0
15
91
1.67
1.01
1.1
1.1
5.3
4.0
u/ml
—
6
19
9
48
1.89
1.01
2.8
1.3
—
—
—
0
0
494
4836
1.41
0.97
22.3
17.4
253.0
254.6
e9/l
0.22
484
4713
10
54
1.87
0.97
1.2
1.2
—
—
—
0
0
24
166
1.47
0.96
1.1
1.2
—
2.8
—
0
10
35
260
1.37
0.96
2.2
2.6
—
—
—
0
0
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
494
4838
1.41
0.95
22.3
17.4
4.5
4.5
e12/l
0.74
482
4701
6
27
2.24
0.93
1.0
1.5
0.8
1.0
g/l
—
6
27
12
70
1.73
0.93
1.8
8.7
—
—
—
0
0
494
4840
1.40
0.92
22.4
17.5
6.5
6.7
e9/l
0.64
483
4701
37
280
1.35
0.91
2.9
2.1
4.1
7.9
ug/l
1.20
29
250
17
111
1.55
0.88
1.3
2.2
11.6
12.0
mg/l
0.09
17
101
18
120
1.52
0.86
1.3
1.1
—
—
—
0
0
72
602
1.23
0.84
2.4
1.6
—
—
—
0
0
76
642
1.22
0.81
2.9
2.9
0.5
0.7
ug/l
3.94
58
405
29
219
1.34
0.75
2.1
2.4
—
—
—
0
0
5
24
2.09
0.74
1.2
1.0
401.0
225.7
ng/l
—
5
13
42
335
1.28
0.74
3.2
5.5
1.1
2.1
mmol/l
1.22
35
265
9
55
1.65
0.74
5.7
2.6
—
—
—
0
0
114
1009
1.17
0.73
2.0
2.7
309.5
7043.3
umol/l
4.38
96
885
5
25
2.01
0.73
1.2
1.4
4.5
7.5
u/l
—
5
20
5
26
1.93
0.71
1.2
1.3
17.9
28.2
nmol/l
—
5
20
23
170
1.37
0.68
1.3
1.4
316.0
254.9
miu/ml
—
10
89
7
42
1.68
0.68
2.1
2.7
—
—
—
0
0
5
27
1.86
0.68
1.8
1.1
—
—
—
0
0
10
62
1.62
0.65
2.0
8.2
54.3
62.9
%
—
10
62
96
1081
0.86
0.63
4.0
3.8
8.6
10.3
mg/mmol
0.14
62
676
8
50
1.61
0.61
1.4
1.3
—
—
—
0
0
8
50
1.61
0.61
1.4
1.2
—
—
—
0
0
14
198
0.70
0.61
4.1
9.0
23.2
24.5
mmol/l
0.59
14
189
20
149
1.36
0.58
1.5
1.4
10.2
9.4
u/l
0.09
13
113
13
89
1.47
0.58
1.4
2.0
—
—
—
0
0
17
124
1.38
0.56
1.1
1.2
—
—
—
0
0
388
3759
1.13
0.55
4.9
5.1
37.1
38.8
mmol/mol
5.05
364
3521
12
82
1.47
0.54
1.3
1.1
—
—
—
0
0
12
82
1.47
0.54
2.1
1.6
184.9
238.1
pmol/l
0.68
12
75
12
82
1.47
0.54
1.3
1.1
—
—
—
0
0
21
160
1.33
0.54
1.4
1.3
—
—
—
0
0
30
369
0.80
0.53
6.0
9.2
4.8
5.2
kpa
1.05
30
357
21
161
1.32
0.52
1.4
1.4
—
—
—
0
0
6
96
0.62
0.52
11.8
4.3
—
—
—
0
0
17
225
0.75
0.52
6.3
9.4
1.3
1.4
%
0.22
17
225
17
225
0.75
0.52
6.8
9.4
0.9
0.7
%
0.66
17
225
36
297
1.23
0.52
2.8
3.2
—
—
—
0
0
61
530
1.17
0.51
2.0
1.9
—
—
—
0
0
30
367
0.81
0.51
5.9
9.2
0.6
1.2
mmol/l
0.49
24
301
7
45
1.56
0.49
1.9
7.0
7.2
7.0
mmol/l
—
7
37
116
1060
1.12
0.48
3.1
3.5
—
—
—
0
0
26
321
0.80
0.48
5.7
9.8
124.2
121.0
g/l
0.28
26
312
10
141
0.70
0.45
5.6
7.9
—
—
—
0
0
28
339
0.82
0.44
5.4
9.6
96.1
96.0
%
0.09
28
331
21
166
1.28
0.44
1.4
1.4
—
—
—
0
0
27
221
1.23
0.43
2.1
2.3
6919.1
2821.5
u/l
0.25
12
97
5
31
1.62
0.43
1.0
1.2
—
—
—
0
0
41
352
1.18
0.41
4.3
3.3
—
—
—
0
0
5
34
1.48
0.40
1.2
1.2
—
—
—
0
0
32
270
1.20
0.39
2.1
2.5
66.3
67.0
g/l
0.22
27
249
10
71
1.42
0.39
2.9
3.3
—
—
—
0
0
0
19
0.00
0.39
0.0
1.3
—
—
—
0
0
9
67
1.35
0.38
2.0
2.5
—
—
—
0
0
9
70
1.29
0.37
1.2
1.1
—
—
—
0
0
9
71
1.27
0.36
1.0
1.6
—
—
—
0
0
6
42
1.43
0.35
1.3
1.1
—
—
—
0
0
94
1017
0.91
0.35
3.0
3.1
59.5
394.5
mg/l
1.59
58
643
109
1170
0.91
0.34
2.8
3.0
8.1
7.7
mmol/l
0.26
97
984
391
3991
0.92
0.34
3.7
3.6
1.1
1.3
mmol/l
5.97
365
3701
25
210
1.20
0.33
1.4
1.5
—
—
—
0
0
25
211
1.19
0.32
1.4
1.6
—
—
—
0
0
25
211
1.19
0.32
1.4
1.6
—
—
—
0
0
106
989
1.09
0.31
4.0
4.4
—
—
—
0
0
46
410
1.13
0.31
22.3
20.5
1.0
1.2
inr
—
5
69
25
212
1.19
0.31
1.4
1.6
—
—
—
0
0
10
75
1.34
0.30
2.7
3.6
58.8
57.8
%
—
10
75
72
782
0.91
0.29
1.8
1.6
449.8
16941966.0
pmol/l
0.76
62
667
23
195
1.19
0.28
1.4
1.6
—
—
—
0
0
36
318
1.14
0.28
1.3
1.4
—
—
—
0
0
59
539
1.11
0.27
1.9
1.9
—
—
—
0
0
20
168
1.20
0.27
2.4
1.8
—
—
—
0
0
51
561
0.90
0.27
1.5
1.4
—
—
—
0
0
22
187
1.18
0.27
6.8
3.4
—
—
—
0
0
5
71
0.70
0.26
4.0
4.3
—
—
—
0
0
5
72
0.69
0.26
1.2
1.4
—
—
—
0
0
9
74
1.22
0.25
2.8
3.2
3.8
4.2
e9/l
—
9
74
19
162
1.18
0.23
1.5
1.6
—
—
—
0
0
12
97
1.24
0.23
1.2
1.2
—
—
—
0
0
5
39
1.28
0.23
1.4
1.0
—
—
—
0
0
10
79
1.27
0.22
1.2
1.2
—
—
—
0
0
86
913
0.93
0.22
3.5
3.3
1.0
1.0
kg/l
0.10
15
121
5
41
1.22
0.22
1.6
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
9.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.4
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
19
164
1.16
0.20
1.9
4.7
0.7
0.7
%
0.06
19
159
10
123
0.81
0.20
2.9
4.1
—
—
—
0
0
10
123
0.81
0.20
1.2
1.5
44.9
196.8
pmol/l
—
10
118
9
111
0.81
0.20
1.1
1.3
—
—
—
0
0
39
356
1.10
0.19
4.8
4.0
—
—
—
0
0
6
52
1.16
0.19
2.0
2.1
—
—
—
0
0
7
59
1.19
0.18
1.0
1.3
—
—
nmol/l
—
0
0
22
245
0.89
0.16
2.4
2.4
19.5
40.9
u/ml
1.21
22
233
31
285
1.09
0.14
4.5
4.9
0.3
0.5
%
0.47
11
71
119
1153
1.04
0.12
3.8
3.0
—
—
—
0
0
16
179
0.89
0.12
6.9
12.8
—
—
—
0
0
18
199
0.90
0.11
3.2
7.0
—
—
—
0
0
410
4133
0.96
0.11
4.2
4.0
1.5
1.5
mmol/l
0.33
386
3846
32
299
1.07
0.11
4.6
5.1
0.0
0.2
%
3.09
13
90
424
4210
1.04
0.10
4.8
4.5
2.8
2.8
mmol/l
0.19
401
3915
5
44
1.14
0.10
3.4
4.5
—
—
—
0
0
18
165
1.09
0.09
2.9
4.0
24.9
24.9
mmol/l
0.05
18
159
417
4144
1.03
0.08
4.2
4.0
4.6
4.7
mmol/l
0.91
395
3874
7
68
1.03
0.08
1.4
1.8
—
—
—
0
0
16
172
0.93
0.06
7.9
11.1
24.8
24.7
mmol/l
0.12
16
163
33
318
1.04
0.04
4.5
4.9
0.3
0.9
%
2.34
15
102
20
190
1.05
0.04
2.7
3.6
—
—
—
0
0
11
119
0.92
0.04
1.8
3.3
8.1
8.8
kpa
0.59
11
111
26
250
1.04
0.03
2.7
3.5
7.4
7.4
ph
—
5
27
22
214
1.03
0.00
1.0
1.1
—
—
—
0
0
28
283
0.99
0.00
4.8
5.2
0.0
0.1
%
0.71
11
76
108
1075
1.01
0.00
4.0
3.5
0.0
0.0
estimate
0.88
40
390
106
1063
1.00
0.00
5.0
4.6
1.5
2.6
ug/l
2.16
99
950
6
62
0.97
0.00
1.0
1.2
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
2.8
—
56.2
—
0
6
0
6
0.00
0.00
0.0
3.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
0.00
0.0
2.3
—
7154.4
—
0
8
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
12.1
—
—
—
0
0
7
73
0.96
0.00
4.3
12.7
10.6
11.1
mmol/l
—
7
66
7
73
0.96
0.00
4.3
12.7
105.3
105.0
mmol/l
—
7
66
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.4
—
1.2
—
0
9
9
94
0.96
0.00
1.8
2.5
25.1
24.9
mmol/l
—
9
83
28
280
1.00
0.00
1.5
1.4
—
—
—
0
0
5
52
0.96
0.00
1.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
21.5
—
0.4
—
0
8
0
7
0.00
0.00
0.0
1.0
—
3.3
—
0
7
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.8
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.6
—
199.0
—
0
5
0
5
0.00
-0.00
0.0
1.6
—
4.5
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint AB1_OTHER_PROTOZOAL and mortality.

Females

Parameter HR [95% CI] p-value
AB1_OTHER_PROTOZOAL 1.862 [1.43, 2.42] < 0.001
Birth year 0.997 [0.99, 1.01] 0.498

During the follow-up period (1.1.1998 — 31.12.2019), 137 out of 1428 females with AB1_OTHER_PROTOZOAL died.

Males

Parameter HR [95% CI] p-value
AB1_OTHER_PROTOZOAL 1.772 [1.39, 2.27] < 0.001
Birth year 0.987 [0.98, 1.0] 0.013

During the follow-up period (1.1.1998 — 31.12.2019), 128 out of 1146 males with AB1_OTHER_PROTOZOAL died.

Mortality risk

Mortality risk for people of age

years, who have AB1_OTHER_PROTOZOAL.

N-year risk Females Males
1 0.177% 0.302%
5 1.094% 1.879%
10 2.787% 4.981%
15 5.699% 9.485%
20 9.974% 15.868%

Relationships between endpoints

Index endpoint: AB1_OTHER_PROTOZOAL – Other protozoal intestinal diseases

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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