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Malignant neoplasm of other and unspecified parts of biliary tract, excluding all cancers (controls excluding all cancers)

C3_BILIARY_TRACT_EXALLC

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 C24
  • Hospital discharge: ICD-9 156
  • Hospital discharge: ICD-8 156
  • Cause of death: ICD-10 C24
  • Cause of death: ICD-9 156
  • Cause of death: ICD-8 156
  • Cause of death: excluded ICD-9 1560
  • Cause of death: excluded ICD-8 1560
  • Cancer registry: Topography ICD-O-3 C24
  • Cancer registry: Morphology ICD-O-3 ANY
  • Cancer registry: Behaviour codes 3

3 out of 7 registries used, show all original rules.

679

4. Check minimum number of events

None

679

5. Include endpoints

None

679

6. Filter based on genotype QC (FinnGen only)

679

Control definitions (FinnGen only)

Control exclude
C3_CANCER, C3_CANCER_WIDE_EXALLC

Extra metadata

First used in FinnGen datafreeze
DF12

Similar endpoints

List of similar endpoints to Malignant neoplasm of other and unspecified parts of biliary tract, excluding all cancers (controls excluding all cancers) based on the number of shared cases.

Venn diagram with an highlighted set fully inside another set Similar with more cases:

Venn diagram with a set fully inside an highlighted set Similar with less cases:

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 679 285 394
Unadjusted period prevalence (%) 0.14 0.10 0.17
Median age at first event (years) 71.06 70.66 71.35

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
394
Matched controls
3939
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
130
Kela drug reimbursment
Malignant tumour
+∞
298.2
247
*
A03FA01
ATC
metoclopramide; systemic, rectal
26.6
148.7
225
187
C24.9
ICD-10 Finland
Malignant neoplasm: Biliary tract, unspecified
+∞
146.2
131
*
K83.1
ICD-10 Finland
Obstruction of bile duct
201.9
135.2
134
10
H02AB02
ATC
dexamethasone; systemic
148.9
134.5
137
14
A04AA02
ATC
granisetron; systemic, transdermal
+∞
129.5
117
*
WD125
NOMESCO Finland
Demanding cystostatic therapy of methastized malignancy
+∞
120.1
109
*
Z51.5
ICD-10 Finland
Palliative care
61.0
118.4
137
34
UJK02
NOMESCO Finland
ERCP
62.0
115.3
133
32
JLC30
NOMESCO Finland
Pancreatoduodenectomy
697.3
110.5
104
*
JKE18
NOMESCO Finland
Endoscopic internal drainage of bile duct
697.3
110.5
104
*
R17
ICD-10 Finland
Hyperbilirubinaemia, with or without jaundice, not elsewhere classified
89.0
109.4
119
19
L01BC06
ATC
capecitabine; oral
+∞
102.7
94
*
N02AA05
ATC
oxycodone; systemic
13.4
96.6
194
266
D37.6
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Liver, gallbladder and bile ducts
98.9
95.8
103
14
C22.1
ICD-10 Finland
Malignant neoplasm: Intrahepatic bile duct carcinoma
+∞
94.7
87
*
C25.0
ICD-10 Finland
Malignant neoplasm: Head of pancreas
+∞
85.6
79
*
JKE98
NOMESCO Finland
Other transduodenal endoscopic operation on bile duct or ampulla of Vater
80.6
84.1
93
15
C24.1
ICD-10 Finland
Malignant neoplasm: Ampulla of Vater
+∞
81.1
75
*
8160/3-C24.9
ICD-O-3
Cholangiocarcinoma of billiary tract, NOS
+∞
81.1
75
*
C78.7
ICD-10 Finland
Secondary malignant neoplasm of liver and intrahepatic bile duct
+∞
77.7
72
*
A09AA02
ATC
multienzymes (lipase, protease etc.)
60.1
76.7
89
19
133
Kela drug reimbursment
Severe chronic pancreatic insufficiency
125.0
76.2
80
8
WX302
NOMESCO Finland
Thoracal epidural anesthesy
33.4
72.1
95
37
D37.7
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Other digestive organs
46.1
71.3
87
24
WD105
NOMESCO Finland
Cystostatic therapy of methastized malignancy
801.1
70.3
67
*
C24.0
ICD-10 Finland
Malignant neoplasm: Extrahepatic bile duct
+∞
69.9
65
*
JN4BD
NOMESCO Finland
Extensive body CT
17.8
68.6
112
86
C79.8
ICD-10 Finland
Secondary malignant neoplasm of other specified sites
+∞
64.3
60
*
JKE02
NOMESCO Finland
Transduodenal endoscopic incision of common bile duct orifice
51.8
63.8
76
18
8140/3-C24.1
ICD-O-3
Adenocarcinoma, NOS, of ampulla of Vater
+∞
58.8
55
*
C24.09
ICD-10 Finland
Biliary duct or passage NOS
+∞
56.6
53
*
JK3BT
NOMESCO Finland
Catherisation of bile duct with X-ray guidance
304.9
53.5
53
*
C24.00
ICD-10 Finland
Hepatic duct
+∞
53.3
50
*
K83.0
ICD-10 Finland
Cholangitis
42.9
52.6
65
18
JJ2AT
NOMESCO Finland
Biopsy of liver with ultrasound guidance
48.7
51.5
62
15
C24.02
ICD-10 Finland
Common bile duct
+∞
51.2
48
*
JN4CD
NOMESCO Finland
Very extensive body CT
26.0
50.6
71
33
JL5SB
NOMESCO Finland
Endoscopic retrograd cholangiopancreaticography
36.1
49.9
64
21
8000/3-C24.9
ICD-O-3
Neoplasm, malignant of billiary tract, NOS
+∞
49.0
46
*
8160/3-C24.0
ICD-O-3
Cholangiocarcinoma of extrahepatic bile duct
+∞
49.0
46
*
A04AA01
ATC
ondansetron; systemic, rectal
23.9
43.9
63
31
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
10.1
43.0
91
114
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
5.1
42.2
168
502
WZC20
NOMESCO Finland
Multidisciplinary treatment meeting
42.5
42.1
52
14
JN4AD
NOMESCO Finland
Body CT examination
13.6
41.9
75
67
8140/3-C24.0
ICD-O-3
Adenocarcinoma, NOS, of extrahepatic bile duct
+∞
41.4
39
*
WB103
NOMESCO Finland
Simple adjuvant cytostatic therapy
+∞
41.4
39
*
N02AB03
ATC
fentanyl; nasal, sublingual, transdermal
14.4
39.2
68
56
8000/3-C24.0
ICD-O-3
Neoplasm, malignant of extrahepatic bile duct
+∞
38.1
36
*
WX602
NOMESCO Finland
Repeated or continuing anesthesia shots throug a catheter
12.8
37.2
68
63
WB113
NOMESCO Finland
Multiple adjuvant cytostatic therapy
+∞
37.1
35
*
WZC30
NOMESCO Finland
Teaching
7.6
36.4
92
152
JN3BD
NOMESCO Finland
Extensive abdominal CT
6.5
34.9
100
196
R50.9
ICD-10 Finland
Fever, unspecified
5.5
34.7
117
281
TPH04
NOMESCO Finland
Cathetrisation of vein
4.5
33.5
143
439
C24.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of biliary tract
+∞
32.8
31
*
JKE22
NOMESCO Finland
Endoscopic extraction of foreign body from bile duct
350.5
32.3
32
*
JN1DG
NOMESCO Finland
Very extensive MRI examination of upper part of abdomen with high intensity magnet
29.9
32.2
43
16
A04AA55
ATC
palonosetron, combinations; systemic
+∞
31.7
30
*
A49.9
ICD-10 Finland
Bacterial infection, unspecified
5.4
31.2
104
243
JAH01
NOMESCO Finland
Laparoscopy
13.4
31.0
55
47
JK3NB
NOMESCO Finland
Percutaneous transhepatic cholangiography
+∞
30.6
29
*
B01AB10
ATC
tinzaparin; parenteral
11.5
30.4
58
58
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
9.3
30.1
65
82
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
5.3
29.6
101
241
JK4ZT
NOMESCO Finland
Percutaneous transhepatic implantation of bile duct prothesis
+∞
29.5
28
*
C61
ICD-10 Finland
Malignant neoplasm of prostate
+∞
28.5
27
*
C25.9
ICD-10 Finland
Malignant neoplasm: Pancreas, unspecified
+∞
28.5
27
*
8140/3-C61.9
ICD-O-3
Adenocarcinoma, NOS, of prostate gland
301.6
28.1
28
*
601
Kela drug reimbursment
Severe malabsorption of nutrients, mainly fats
155.9
28.0
29
*
B01AB05
ATC
enoxaparin; parenteral
3.6
27.6
166
665
C22.9
ICD-10 Finland
Malignant neoplasm: Liver, unspecified
+∞
27.4
26
*
JN3CD
NOMESCO Finland
Abdominal CT examination both without and with contrast
11.3
26.7
51
51
JK3FT
NOMESCO Finland
Exchange of bile duct catheter with radiological guidance
+∞
26.3
25
*
JN3AD
NOMESCO Finland
Abdominal CT examination
6.7
25.0
67
117
WD115
NOMESCO Finland
Multiple cystostatic therapy of methastized malignancy
+∞
24.2
23
*
C23
ICD-10 Finland
Malignant neoplasm of gallbladder
+∞
24.2
23
*
8140/3-C24.9
ICD-O-3
Adenocarcinoma, NOS, of billiary tract, NOS
+∞
24.2
23
*
C78.0
ICD-10 Finland
Secondary malignant neoplasm of lung
+∞
23.1
22
*
JN1CG
NOMESCO Finland
Extensive MRI examination of upper part of abdomen with high intensity magnet
20.5
23.0
34
18
JKE32
NOMESCO Finland
Endoscopic dilatation of bile duct
127.3
22.8
24
*
JA3AT
NOMESCO Finland
Cathetrisation of abdominal cavity with ultrasound guidance
29.3
22.6
30
11
C78.6
ICD-10 Finland
Secondary malignant neoplasm of retroperitoneum and peritoneum
+∞
22.1
21
*
WF049
NOMESCO Finland
Radiotherapy of metastasis
+∞
22.1
21
*
TPH07
NOMESCO Finland
Cathetrisation of artery
5.1
21.9
74
171
D37.9
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Digestive organ, unspecified
121.7
21.8
23
*
R4190
NOMESCO Finland
Nutritional therapy
14.5
21.4
36
27
A06AH03
ATC
naloxegol; oral
63.6
21.1
24
*
A04AD12
ATC
aprepitant; systemic
+∞
21.0
20
*
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
8.8
20.7
45
57
WX402
NOMESCO Finland
General anaesthesia
4.3
20.1
80
218
XX3DW
NOMESCO Finland
Time consuming IT work
6.9
19.9
51
83
L03AA02
ATC
filgrastim; parenteral
210.0
19.7
20
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.2
19.0
123
494
TPX10
NOMESCO Finland
Implantation of vascular injection port
13.2
19.0
33
27
C22.0
ICD-10 Finland
Malignant neoplasm: Liver cell carcinoma
+∞
18.9
18
*
J01MA12
ATC
levofloxacin; systemic
3.2
18.6
115
447
WW500
NOMESCO Finland
Blood transfusion
13.3
17.9
31
25
K83.9
ICD-10 Finland
Disease of biliary tract, unspecified
38.7
17.8
22
6
D77
ICPC
Malignant digestive neopl other/NOS
+∞
16.8
16
*
A02BC02
ATC
pantoprazole; systemic
2.5
16.3
273
1860
JKE25
NOMESCO Finland
Endoscopic external drainage of bile duct
166.2
15.6
16
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
3.3
15.2
84
298
JAH00
NOMESCO Finland
Laparotomy
8.8
15.1
32
39
JK3NT
NOMESCO Finland
Percutaneous transhepatic dilatation of bileducts
+∞
14.7
14
*
116
Kela drug reimbursment
Prostate cancer
+∞
14.7
14
*
ZX012
NOMESCO Finland
Radiotherapy with large shaped fields - isocentric therapy
155.4
14.6
15
*
R18
ICD-10 Finland
Ascites
14.3
13.9
23
17
R10.1
ICD-10 Finland
Pain localized to upper abdomen
3.1
13.6
83
312
C79.5
ICD-10 Finland
Secondary malignant neoplasm of bone and bone marrow
+∞
13.6
13
*
C17.0
ICD-10 Finland
Malignant neoplasm: Duodenum
+∞
13.6
13
*
JDE00
NOMESCO Finland
Gastrojejunostomy
+∞
13.6
13
*
C24.01
ICD-10 Finland
Cystic duct
+∞
13.6
13
*
A06AD11
ATC
lactulose; oral
2.7
13.3
101
439
A05AA02
ATC
ursodeoxycholic acid; oral
16.1
12.7
20
13
UJK12
NOMESCO Finland
Peroral cholangioscopy
72.2
12.7
14
*
WB121
NOMESCO Finland
Demanding neoadjuvant cytostatic therapy
+∞
12.6
12
*
C77.2
ICD-10 Finland
Secondary and unspecified malignant neoplasm: Intra-abdominal lymph nodes
+∞
12.6
12
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
5.5
12.2
36
71
166
Kela drug reimbursment
Dalteparin and tinzaparin (treatment for more than 6 months)
+∞
11.5
11
*
JK3SB
NOMESCO Finland
Endoscopic retrorade cholangiography
123.4
11.5
12
*
D70.82
ICD-10 Finland
Drug-induced neutropenia
123.4
11.5
12
*
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.7
11.3
89
389
ZX120
NOMESCO Finland
Intravenous
3.7
11.0
49
146
WX004
NOMESCO Finland
Patient-controlled sedation
28.9
10.8
14
5
L02AE02
ATC
leuprorelin; implant, parenteral
+∞
10.5
10
*
D76
ICPC
Malignant neoplasm pancreas
+∞
10.5
10
*
8160/3-C22.1
ICD-O-3
Cholangiocarcinoma of intrahepatic bile duct
+∞
10.5
10
*
PJA12
NOMESCO Finland
Sentinel node biopsy
+∞
10.5
10
*
K90.3
ICD-10 Finland
Pancreatic steatorrhoea
33.5
10.4
13
*
XJD02
NOMESCO Finland
Peroral endoscopic ultrasonography
33.5
10.4
13
*
JKA20
NOMESCO Finland
Cholecystectomy
5.9
10.3
28
50
WX892
NOMESCO Finland
Monitored bed care
3.7
10.3
45
132
JL5BG
NOMESCO Finland
MRI examinaiton of bile and pancreas ducts with high intesity magnet
7.1
9.8
23
34
WX002
NOMESCO Finland
Sedation and analgesia
2.4
9.4
86
408
WB123
NOMESCO Finland
Demanding adjuvant cytostatic therapy
+∞
9.4
9
*
JA3BT
NOMESCO Finland
Cathetrisation of abdominal cavity with X-ray guidance
+∞
9.4
9
*
ZXE40
NOMESCO Finland
More than seven and less than nine hours
8.0
9.2
20
26
ZXE20
NOMESCO Finland
More than three and less than five hours
2.7
8.6
60
244
A79
ICPC
Malignancy NOS
91.9
8.4
9
*
E13.9
ICD-10 Finland
Other specified diabetes mellitus, without complications
13.1
8.4
14
11
JKE12
NOMESCO Finland
Endoscopic extraction of calculus from bile duct
8.8
8.4
17
20
Z51.1
ICD-10 Finland
Chemotherapy session for neoplasm
+∞
8.4
8
*
JKC30
NOMESCO Finland
Partial excision of bile duct and anastomosis to jejunum
+∞
8.4
8
*
K75.0
ICD-10 Finland
Abscess of liver
+∞
8.4
8
*
L03AA13
ATC
pegfilgrastim; parenteral
+∞
8.4
8
*
R4110
NOMESCO Finland
Physiotherapy
2.1
8.3
102
552
A98
ICPC
Health maint/preventive medicine
0.5
8.2
241
2960
WF002
NOMESCO Finland
Radical radiotherapy
34.1
8.1
10
*
JA2AT
NOMESCO Finland
Abdominal puncture with ultrasound guidance
34.1
8.1
10
*
C44.31
ICD-10 Finland
Basocellular carcinoma of the skin on another or unspecified part of the face
22.5
8.1
11
5
WX704
NOMESCO Finland
Intubation
3.7
8.0
34
98
WX725
NOMESCO Finland
Noninvasive ventilation
4.5
8.0
27
63
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
6.8
8.0
19
29
K80.5
ICD-10 Finland
Calculus of bile duct without cholangitis or cholecystitis
4.8
7.8
25
55
A41.9
ICD-10 Finland
Sepsis, unspecified
4.4
7.8
27
65
K85.8
ICD-10 Finland
Other acute pancreatitis
15.4
7.8
12
8
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
7.5
175
1197
GD1BD
NOMESCO Finland
Thorax extensive CT-examination
4.2
7.4
27
68
JF1AB
NOMESCO Finland
Passage examination of small bowell with X-ray
13.7
7.4
12
9
WF003
NOMESCO Finland
Adjuvant radiotherapy
+∞
7.3
7
*
Y77
ICPC
Malignant neoplasm prostate
+∞
7.3
7
*
JK3MB
NOMESCO Finland
Postoperative cholangiography
+∞
7.3
7
*
JN5DR
NOMESCO Finland
PET-CT of upper body metabolism
16.1
7.3
11
7
J01MA02
ATC
ciprofloxacin; systemic
1.8
7.3
163
1100
A41.8
ICD-10 Finland
Other specified sepsis
7.2
7.1
16
23
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
4.4
6.7
23
55
K76.9
ICD-10 Finland
Liver disease, unspecified
7.6
6.5
14
19
ZX090
NOMESCO Finland
Other technic of radiotherapy
70.9
6.4
7
*
WX882
NOMESCO Finland
High dependency care
5.7
6.4
17
31
JL5AG
NOMESCO Finland
Simple MRI examinaiton of bile and pancreas ducts with high intesity magnet
11.3
6.3
11
10
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
9.5
6.3
12
13
ZXD30
NOMESCO Finland
Difficulties in perfomrming procedure
4.1
6.3
23
59
8090/3-C44.3
ICD-O-3
Basal cell carcinoma, NOS, of skin of other and unspecified parts of face
+∞
6.3
6
*
JJB50
NOMESCO Finland
Excision of segments V, VI, VII and VIII of liver
+∞
6.3
6
*
C25
ICD-10 Finland
Malignant neoplasm of pancreas
+∞
6.3
6
*
8163/3-C24.1
ICD-O-3
Pancreatobiliary type carcinoma of ampulla of Vater
+∞
6.3
6
*
D13
ICPC
Jaundice
+∞
6.3
6
*
WD305
NOMESCO Finland
Simple therapy of methastized malignancy with biomodifiers
+∞
6.3
6
*
JJ3AT
NOMESCO Finland
Cytology of liver with ultrasound guidance
+∞
6.3
6
*
ZX070
NOMESCO Finland
Intensity modified radiotherapy
+∞
6.3
6
*
L02BB03
ATC
bicalutamide; oral
+∞
6.3
6
*
XZZ00
NOMESCO Finland
Active surveillance of a diagnosed cancer
+∞
6.3
6
*
C67.8
ICD-10 Finland
Malignant neoplasm: Overlapping lesion of bladder
+∞
6.3
6
*
C25.7
ICD-10 Finland
Malignant neoplasm: Other parts of pancreas
+∞
6.3
6
*
C25.1
ICD-10 Finland
Malignant neoplasm: Body of pancreas
+∞
6.3
6
*
C78.8
ICD-10 Finland
Secondary malignant neoplasm of other and unspecified digestive organs
+∞
6.3
6
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.1
165
1159
JL5CG
NOMESCO Finland
Extensive MRI examinaiton of bile and pancreas ducts with high intesity magnet
12.8
6.1
10
8
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.1
117
741

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: C3_BILIARY_TRACT_EXALLC – Malignant neoplasm of other and unspecified parts of biliary tract, excluding all cancers (controls excluding all cancers)

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).