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Hyperosmolality and hypernatraemia

EFO MESH Endpoint Browser PheWeb

E4_HYPEROSMHNAT

Endpoint definition

↥

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 — E87.0
  • Hospital discharge: ICD-9 — 2760
  • Cause of death: ICD-10 — E87.0
  • Cause of death: ICD-9 — 2760

2 out of 7 registries used, show all original rules.

528

4. Check minimum number of events

None

528

5. Include endpoints

None

528

6. Filter based on genotype QC (FinnGen only)

513

Control definitions (FinnGen only)

Control exclude
E4_METABOLIA

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
E87
Name in latin
Hyperosmolalitas

Case counts by codes

↥

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 6622 3751 2831
Only index persons 5696 3249 2447
Unadjusted period prevalence (%)
Whole population 0.09 0.11 0.08
Only index persons 0.11 0.12 0.09
Median age at first event (years)
Whole population 77.28 80.01 73.68
Only index persons 77.45 80.17 73.85

-FinnGen-

Key figures

All Female Male
Number of individuals 513 242 271
Unadjusted period prevalence (%) 0.11 0.09 0.12
Median age at first event (years) 71.91 72.42 71.45

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
528
Matched controls
5280
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
+∞
307.7
525
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
111.9
260.0
134
16
E87.6
ICD-10 Finland
Hypokalaemia
34.4
94.3
61
20
E86
ICD-10 Finland
Volume depletion
120.7
68.8
73
7
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.9
67.9
220
673
N05AN01
ATC
lithium; oral
16.3
56.1
49
33
N05AH03
ATC
olanzapine; systemic
8.3
55.3
79
110
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.9
54.9
94
160
N05AA02
ATC
levomepromazine; systemic
8.6
51.3
70
92
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.8
49.5
264
1109
N03AG01
ATC
valproic acid; systemic, rectal
7.2
49.4
80
128
AA1AD
NOMESCO Finland
CT of head and brain
3.6
45.2
236
966
N17.9
ICD-10 Finland
Acute renal failure, unspecified
8.1
43.7
62
85
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.0
43.1
162
530
N05AX08
ATC
risperidone; systemic
4.5
41.3
118
315
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.2
39.6
126
364
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
3.9
39.5
144
459
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
15.5
39.4
35
24
T36
ICD-10 Finland
Poisoning by systemic antibiotics
9.4
39.4
49
57
R41.0
ICD-10 Finland
Disorientation, unspecified
7.7
39.4
58
83
N05AF03
ATC
chlorprothixene; systemic
12.3
38.2
39
34
R53
ICD-10 Finland
Malaise and fatigue
3.3
35.7
196
806
A28
ICPC
Limited function/disability NOS
3.3
34.6
176
690
N05AX12
ATC
aripiprazole; systemic
9.7
32.5
39
43
N05AH04
ATC
quetiapine; oral
3.5
32.3
138
483
A06AD11
ATC
lactulose; oral
3.2
31.2
159
619
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
10.3
30.6
35
36
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.9
28.7
191
859
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
8.5
28.5
38
48
N05BA06
ATC
lorazepam; systemic, sublingual
4.9
28.3
68
156
E87.5
ICD-10 Finland
Hyperkalaemia
45.2
28.1
34
8
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
9.5
28.0
34
38
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
5.5
27.7
57
114
A10AB05
ATC
insulin aspart; parenteral
4.4
27.5
76
195
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.5
27.2
109
363
G72.8
ICD-10 Finland
Other specified myopathies
8.5
27.2
36
45
F20.9
ICD-10 Finland
Schizophrenia, unspecified
10.5
26.7
30
30
N04AA02
ATC
biperiden; systemic
10.5
26.7
30
30
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.1
25.7
134
523
L28
ICPC
Limited function/disability (L)
2.9
25.4
155
660
N05AB03
ATC
perphenazine; systemic, rectal
6.6
25.3
42
68
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.2
24.9
54
113
N05BA04
ATC
oxazepam; oral
2.7
24.9
190
908
N05AC02
ATC
thioridazine; oral
9.1
24.8
31
36
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.7
24.6
61
143
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
4.1
24.6
73
197
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.5
24.2
95
311
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
5.9
24.1
45
82
N06AB04
ATC
citalopram; systemic
2.9
23.7
146
622
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.0
23.4
43
77
SPAT1234
SPAT
Support of social functional capacity
4.5
23.4
61
149
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
4.6
23.2
59
141
A10AE04
ATC
insulin glargine; parenteral
3.6
23.0
83
257
N05CD07
ATC
temazepam; oral
3.0
22.5
119
465
103
Kela drug reimbursment
Diabetes, insulin-treated
2.5
21.2
191
975
C03CA01
ATC
furosemide; systemic
2.4
21.2
254
1475
E23.2
ICD-10 Finland
Diabetes insipidus
80.1
20.8
23
*
F05.9
ICD-10 Finland
Delirium, unspecified
7.3
20.6
31
45
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.1
20.5
98
360
N03AF02
ATC
oxcarbazepine; oral
6.7
20.3
33
52
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
4.3
20.2
56
143
L89
ICD-10 Finland
Decubitus ulcer and pressure area
7.1
20.2
31
46
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.3
19.5
227
1290
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.5
19.2
154
739
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.7
19.2
66
197
N03AX14
ATC
levetiracetam; systemic
6.9
18.9
30
46
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.3
18.4
75
250
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.7
18.2
123
542
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.8
17.6
106
440
A10BA02
ATC
metformin; oral
2.3
17.3
187
1018
N05AA01
ATC
chlorpromazine; systemic, rectal
16.7
17.2
27
17
N05BA01
ATC
diazepam; systemic, rectal
2.8
17.1
99
402
H02AB09
ATC
hydrocortisone; systemic
7.1
17.1
26
38
102
Kela drug reimbursment
Diabetes insipidus
51.8
17.1
20
*
N05AD01
ATC
haloperidol; systemic
4.7
16.9
40
90
N03AX09
ATC
lamotrigine; oral
5.7
16.9
32
59
I50.9
ICD-10 Finland
Heart failure, unspecified
2.5
16.8
136
652
N05AH02
ATC
clozapine; systemic
14.0
16.7
28
21
ZXD05
NOMESCO Finland
Urgent procedure
2.3
16.4
177
959
A04
ICPC
Weakness/tiredness general
2.7
16.4
104
442
P99
ICPC
Psychological disorders other
7.0
16.3
25
37
A41.9
ICD-10 Finland
Sepsis, unspecified
4.4
16.1
42
102
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
25.4
16.1
22
9
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
5.0
15.9
35
74
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
18.4
15.3
23
13
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
20.8
15.2
22
11
N30.0
ICD-10 Finland
Acute cystitis
2.6
15.2
101
439
R11
ICD-10 Finland
Nausea and vomiting
3.1
15.0
68
241
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.7
14.9
49
141
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.5
14.9
113
522
R50.9
ICD-10 Finland
Fever, unspecified
2.6
14.8
99
431
N06AX11
ATC
mirtazapine; oral
2.1
14.8
196
1146
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
14.7
80
313
N25.1
ICD-10 Finland
Nephrogenic diabetes insipidus
+∞
14.6
14
*
SPAT1254
SPAT
Administration of medicine
2.4
14.6
117
555
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
17.6
14.4
22
13
I10
ICD-10 Finland
Essential (primary) hypertension
2.1
14.2
358
2635
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
6.6
14.2
23
36
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.6
14.2
91
388
F10.25
ICD-10 Finland
Alcohol dependence continuous use
11.3
14.1
26
24
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
11.9
13.9
25
22
C08CA01
ATC
amlodipine; oral
2.0
13.8
237
1514
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.0
13.8
64
229
N06AB06
ATC
sertraline; oral
3.0
13.7
65
236
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
3.4
13.6
52
166
A10AE05
ATC
insulin detemir; parenteral
3.7
13.5
45
131
188
Kela drug reimbursment
Psychosis requiring demanding treatment
26.5
13.4
18
7
I50.0
ICD-10 Finland
Congestive heart failure
2.7
13.4
79
322
E23.00
ICD-10 Finland
Panhypopituitarism
41.2
13.2
16
*
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
6.3
13.0
22
36
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.1
12.9
171
990
T90
ICPC
Diabetes non-insulin dependent
2.2
12.9
141
759
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
14.5
12.9
21
15
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.7
12.8
78
323
SPAT1262
SPAT
Handing over of treatment supplies
2.3
12.8
115
571
WX872
NOMESCO Finland
Intensive care
3.9
12.7
39
107
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
5.4
12.6
25
48
F03
ICD-10 Finland
Unspecified dementia
3.1
12.6
55
190
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
133.0
12.5
13
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
12.2
99
469
SPAT1229
SPAT
Assessment of need for aid
2.8
12.2
64
245
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
16.4
12.2
19
12
N06DX01
ATC
memantine; oral
2.5
12.1
85
377
SPAT1301
SPAT
No procedures
2.0
12.0
193
1191
N05CF01
ATC
zopiclone; oral
2.0
12.0
206
1300
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
5.0
12.0
26
54
S06.0
ICD-10 Finland
Concussion
2.6
12.0
73
302
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
12.1
11.9
21
18
N06AA12
ATC
doxepin; systemic
3.5
11.9
43
132
F10.20
ICD-10 Finland
Alcohol dependence currently independent
6.0
11.9
21
36
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
15.1
11.9
19
13
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.7
11.8
38
108
R55
ICD-10 Finland
Syncope and collapse
2.5
11.8
83
369
SPAT1216
SPAT
Assessment of functional ability
2.2
11.5
115
594
SPAT1172
SPAT
Guidance concerning hydration
5.3
11.4
23
45
SPAT1307
SPAT
Psychosocial counselling and guidance
4.2
11.3
30
74
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
3.7
11.2
36
102
Y94.0
ICD-10 Finland
Accident at home
5.4
11.2
22
42
N05AF05
ATC
zuclopenthixol; systemic
11.5
11.1
20
18
N30.9
ICD-10 Finland
Cystitis, unspecified
3.1
10.9
47
161
P20
ICPC
Memory disturbance
2.2
10.9
114
599
P29
ICPC
Psychological sympt/compl other
3.8
10.8
34
95
F10.09
ICD-10 Finland
Alcohol intoxication UNS
5.7
10.8
20
36
C09AA05
ATC
ramipril; oral
1.9
10.7
164
991
A10BH01
ATC
sitagliptin; oral
2.5
10.5
69
296
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.5
10.5
72
316
F10.26
ICD-10 Finland
Alcohol dependence periodic alcoholism
16.4
10.4
16
10
N05BE01
ATC
buspirone; oral
4.6
10.4
25
57
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.1
10.4
108
566
R33
ICD-10 Finland
Retention of urine
2.5
10.3
68
292
E83.50
ICD-10 Finland
Hypercalcemia
19.2
10.3
15
8
C07AB07
ATC
bisoprolol; oral
1.8
10.2
292
2137
W19
ICD-10 Finland
Unspecified fall
2.4
10.2
72
320
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
17.1
9.9
15
9
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
2.3
9.9
84
404
AA400
NOMESCO Finland
Electroconvulsive therapy
26.6
9.9
13
5
N06AB03
ATC
fluoxetine; oral
2.4
9.8
70
312
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
3.3
9.8
38
122
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.4
9.7
24
56
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.9
9.7
160
986
E000001, ,
ATC
2.1
9.6
106
566
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
15.4
9.6
15
10
N06AX16
ATC
venlafaxine; oral
2.4
9.5
68
303
SPAT1263
SPAT
Sampling
1.8
9.5
224
1537
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
7.8
9.5
21
28
A10BH05
ATC
linagliptin; oral
3.1
9.5
41
141
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
17.9
9.4
14
8
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
4.1
9.4
26
66
G30.1
ICD-10 Finland
Alzheimer disease with late onset
2.4
9.3
65
287
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.6
9.3
54
218
P72
ICPC
Schizophrenia
7.9
9.2
20
26
N19
ICD-10 Finland
Unspecified kidney failure
3.6
9.2
30
86
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
4.5
9.2
22
50
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.4
9.1
67
303
XA800
NOMESCO Finland
Neuropsychological investigation
4.2
9.1
24
59
F31.2
ICD-10 Finland
Bipolar affective disorder, current episode manic with psychotic symptoms
37.4
9.0
11
*
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
9.0
107
586
N05BA02
ATC
chlordiazepoxide; systemic
4.3
9.0
23
55
F31
ICD-10 Finland
Bipolar affective disorder
19.0
9.0
13
7
101
Kela drug reimbursment
Anterior pituitary hypofunction
19.0
9.0
13
7
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
5.0
8.9
19
39
N03AF01
ATC
carbamazepine; oral, rectal
2.9
8.8
41
147
D64.9
ICD-10 Finland
Anaemia, unspecified
2.2
8.8
78
382
29570
ICD-8 Finland
Schizophrenia, Schizo-affective type
50.8
8.7
10
*
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
2.8
8.7
46
177
2957A
ICD-9 Finland
Schizophrenic psychoses, Schizo-affective type
28.0
8.5
11
*
C03DA01
ATC
spironolactone; oral
2.2
8.5
81
408
9690A
ICD-9 Finland
Poisoning by psychotropic agents, Antidepressants
91.5
8.4
9
*
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.5
8.4
57
248
A10BB12
ATC
glimepiride; oral
2.4
8.4
59
261
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
9.7
8.3
16
17
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.2
8.1
32
104
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
10.3
8.1
15
15
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
4.0
8.1
23
60
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.5
8.1
27
79
C10AA01
ATC
simvastatin; oral
1.7
8.0
237
1712
A10AC01
ATC
insulin (human); parenteral
2.4
7.9
56
248
WX730
NOMESCO Finland
Conventional respirator
7.9
7.9
17
22
E66.00
ICD-10 Finland
Metabolic syndrome
3.4
7.9
29
90
SPAT1251
SPAT
Organisation of medication
3.3
7.8
30
96
AN1
HP
Coronary angiography
2.2
7.8
66
317
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
7.8
196
1354
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
15.3
7.7
12
8
G21.1
ICD-10 Finland
Other drug-induced secondary parkinsonism
45.7
7.7
9
*
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.7
7.7
42
164
F10.31
ICD-10 Finland
Withdrawal symptoms caused by alcohol with seizures
18.7
7.6
11
6
F31.3
ICD-10 Finland
Bipolar affective disorder, current episode mild or moderate depression
25.4
7.6
10
*
F31.8
ICD-10 Finland
Other bipolar affective disorders
9.0
7.6
15
17
J01EA01
ATC
trimethoprim; systemic
1.8
7.5
148
951
N07BB01
ATC
disulfiram; oral
3.5
7.5
25
73
E87.2
ICD-10 Finland
Acidosis
81.2
7.4
8
*
29610
ICD-8 Finland
Affective psychoses, Manic-depression psychosis, manic type
81.2
7.4
8
*
R63.1
ICD-10 Finland
Polydipsia
81.2
7.4
8
*
F10.24
ICD-10 Finland
Alcohol depence active use
7.8
7.4
16
21
N06AB10
ATC
escitalopram; oral
2.0
7.4
87
473
TAB00
NOMESCO Finland
Lumbar puncture
3.2
7.4
29
94
WX882
NOMESCO Finland
High dependency care
3.6
7.3
24
69
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
7.3
46
193
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.8
7.3
37
139
E78.29
ICD-10 Finland
Other mixed hyperlipidaemia
+∞
7.3
7
*
205
Kela drug reimbursment
Chronic hypertension
1.7
7.3
175
1188
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
4.4
7.3
18
42
UKC02
NOMESCO Finland
Cystoscopy
1.9
7.3
103
598
J01MA02
ATC
ciprofloxacin; systemic
1.7
7.3
212
1516
F10.49
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without information about seizures
16.0
7.3
11
7
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.3
7.2
54
246
N06DA02
ATC
donepezil; oral
2.3
7.2
58
273
3018D
ICD-9 Finland
Personality disorders, Other personality disorders[EPÄVAKAA PERSOONALLISUUS]
20.3
7.2
10
5
S97
ICPC
Chronic ulcer skin
2.5
7.1
47
202
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
10.2
7.1
13
13
SPAT1255
SPAT
Intravenous administration of medicine
2.5
7.1
44
184
N03AE01
ATC
clonazepam; systemic
2.8
7.1
36
136
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.1
7.0
29
97
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
3.0
7.0
30
103
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.2
6.9
62
304
R60.0
ICD-10 Finland
Localized oedema
2.1
6.9
73
383
K59.09
ICD-10 Finland
Constipation, unspecified
2.5
6.9
45
193
SPAT1305
SPAT
Counselling and guidance related to physical exercise
2.2
6.8
56
265
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
3.2
6.8
27
88
N05AF01
ATC
flupentixol; systemic
6.2
6.8
17
28
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
9.5
6.8
13
14
R99
ICD-10 Finland
Other ill-defined and unspecified causes of mortality
3.2
6.8
26
83
2962C
ICD-9 Finland
Affective psychoses, Major depressive disorder, single episode[PSYCHOSIS BIPOLARIS MANICA,KESKIVAIKEA]
40.6
6.8
8
*
H02AA02
ATC
fludrocortisone; oral
7.3
6.7
15
21
SPAT1156
SPAT
Guidance concerning treatment of rash and skin
1.9
6.7
85
474
Z02.4
ICD-10 Finland
Examination for driving licence
0.5
6.7
60
1109
N06AB05
ATC
paroxetine; oral
2.9
6.7
31
111
29599
ICD-8 Finland
Schizophrenia, Unspecified type
22.8
6.7
9
*
R42
ICD-10 Finland
Dizziness and giddiness
1.8
6.7
127
805
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
6.0
6.7
17
29
G25.9
ICD-10 Finland
Extrapyramidal and movement disorder, unspecified
8.0
6.6
14
18
G91.2
ICD-10 Finland
Normal-pressure hydrocephalus
4.3
6.6
17
41
P16
ICPC
Acute alcohol abuse
7.0
6.6
15
22
F01.9
ICD-10 Finland
Vascular dementia, unspecified
3.7
6.5
20
55
N02AA05
ATC
oxycodone; systemic
1.8
6.5
114
705
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
6.5
110
674
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.1
6.5
68
355
S72.1
ICD-10 Finland
Pertrochanteric fracture
3.1
6.4
26
86
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
2.5
6.4
41
174
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
5.3
6.4
18
35
V03AA01, ,
ATC
6.1
6.3
16
27
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
2.4
6.3
45
201
SPAT1083
SPAT
Initiation and monitoring of IV fluid therapy
2.8
6.3
32
121
F25
ICD-10 Finland
Schizoaffective disorders
+∞
6.3
6
*
K90
ICPC
Stroke/cerebrovascular accident
3.8
6.2
19
52
IFB01
NOMESCO Finland
Electroconvulsive Therapy (ECT)
27.0
6.2
8
*
J01CA08
ATC
pivmecillinam; oral
1.6
6.2
190
1362
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.3
6.2
45
202
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
3.5
6.2
21
62
I20.09
ICD-10 Finland
Unstable angina
2.5
6.2
37
152
N06AX21
ATC
duloxetine; oral
2.2
6.2
54
263
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
6.2
132
864
F10.39
ICD-10 Finland
Withdrawal symptoms caused by alcohol UNS
12.7
6.1
10
8
NFJ54
NOMESCO Finland
Internal fixation of fracture of upper femur with intramedullary nail
3.7
6.1
19
53
N06AX03
ATC
mianserin; oral
2.7
6.1
32
123
SPAT1260
SPAT
Consultation of another employee
1.8
6.1
92
544
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.1
444
3922
SPAT1299
SPAT
Other function in accordance with podiatry nomenclature
5.3
6.1
17
33
SPAT1167
SPAT
Insertion of urinary catheter
3.1
6.0
25
84
R26.8
ICD-10 Finland
Other and unspecified abnormalities of gait and mobility
4.0
6.0
17
44

LabWAS

↥
OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
107
38
35.06
163.37
2.0
1.4
67.61
66.53
mmol/l
0.05
95
30
67
31
24.61
91.86
2.7
2.0
305.31
282.95
mosm/kgh2o
3.47
55
19
128
277
5.78
58.66
2.4
2.1
383.04
373.58
nmol/l
0.15
119
250
222
833
3.87
49.27
3.9
2.8
505.26
556.55
mosm/kgh2o
2.14
198
712
171
553
4.09
46.69
5.5
3.4
0.84
0.82
mmol/l
0.85
165
521
50
48
11.40
46.19
8.6
4.3
384.59
353.00
umol/l
0.56
41
41
124
363
4.16
38.18
4.9
3.5
2.52
2.14
mmol/l
0.45
111
296
250
1175
3.14
36.36
6.7
3.9
—
—
—
0
0
242
1154
3.03
33.72
4.0
2.0
322.60
285.91
u/l
0.18
232
1076
130
457
3.45
30.03
11.7
6.1
1.45
1.44
mmol/l
0.01
112
345
93
279
3.83
27.13
4.9
4.0
7.40
7.40
ph
0.07
19
25
328
2031
2.62
25.09
13.4
5.7
1.21
1.22
mmol/l
0.12
284
1720
298
1771
2.57
24.73
6.3
4.2
31.19
34.77
g/l
14.65
276
1614
231
1226
2.57
24.26
3.4
2.3
55.35
61.76
u/l
0.75
219
1116
125
483
3.08
24.25
11.1
5.3
107.27
104.29
mmol/l
2.20
125
483
321
1997
2.55
23.84
17.4
17.2
1.32
1.34
inr
0.18
106
556
68
181
4.16
23.30
2.5
1.9
9.69
3.31
ug/l
0.54
60
154
242
1333
2.51
23.23
4.8
3.3
—
—
—
0
0
41
72
6.09
22.77
1.4
1.4
4.50
3.75
mmol/l
2.23
41
65
354
2335
2.57
22.74
11.7
4.1
7.43
6.76
mmol/l
4.90
345
2178
132
550
2.87
22.18
2.4
2.1
2.21
2.31
g/l
0.88
121
502
86
279
3.49
22.12
7.5
4.4
—
—
—
0
0
322
2058
2.45
21.77
6.6
6.0
11.11
12.09
umol/l
0.78
305
1942
40
77
5.54
20.17
4.2
2.3
—
—
—
0
0
42
85
5.28
20.05
1.4
1.4
513.74
477.31
mg/l
0.22
42
80
87
302
3.25
20.00
12.4
6.7
—
—
—
0
0
178
902
2.47
19.87
2.1
1.7
1311.10
1176.19
nmol/l
0.85
141
673
27
35
8.08
19.72
1.6
1.3
—
—
—
0
0
38
73
5.53
19.19
1.5
1.4
1.85
4.00
e6/l
1.01
33
62
291
1844
2.29
19.15
12.6
5.1
1.20
1.21
mmol/l
0.92
273
1646
134
614
2.58
18.35
2.5
2.1
10.33
12.72
umol/l
3.86
123
570
261
1612
2.22
17.90
6.6
3.5
124.78
56.90
ng/l
0.50
226
1214
36
71
5.37
17.66
6.4
2.9
—
—
—
0
0
96
381
2.86
17.35
1.9
2.2
0.20
0.20
g/l
0.08
86
352
119
529
2.61
17.25
2.5
2.2
19.71
22.41
%
1.01
94
450
123
557
2.58
17.15
2.2
2.0
32.21
29.75
s
1.10
118
534
189
1038
2.28
17.12
2.6
2.1
3.08
3.38
mg/l
0.86
166
881
166
880
2.29
16.21
3.4
2.4
5.96
5.29
e6/l
0.37
152
791
78
287
3.02
16.11
3.3
3.3
88.15
83.85
ng/l
0.17
60
243
108
476
2.60
15.83
2.4
2.7
1.83
1.79
%
0.15
95
424
36
81
4.70
15.18
3.8
1.9
121.84
126.44
g/l
0.44
31
59
34
73
4.91
15.15
4.9
1.9
14.76
15.75
%
0.59
22
33
55
179
3.31
13.91
13.5
9.0
—
—
—
0
0
206
1260
2.04
13.49
4.2
3.1
83.35
124.90
e6/l
0.33
183
981
164
927
2.12
13.25
1.8
1.8
467.31
7968567.12
pmol/l
0.50
134
753
187
1129
2.02
12.51
4.0
3.1
37.44
34.34
u/l
0.36
177
1064
36
96
3.95
12.21
7.8
3.2
7.43
7.42
ph
0.10
29
85
28
62
4.71
12.03
1.3
1.4
—
—
—
0
0
79
343
2.53
11.77
2.2
3.0
67.54
68.87
e9/l
0.14
67
271
234
1552
1.91
11.70
2.7
2.1
76.15
78.74
nmol/l
0.60
205
1342
189
1180
1.94
11.25
6.5
3.4
7.41
7.40
ph
0.64
52
228
207
1336
1.90
11.11
3.5
3.0
2451.47
1798.34
ng/l
0.51
186
1138
349
2668
1.91
10.92
8.0
4.7
3445.47
3665.51
e6/l
0.03
15
45
30
76
4.12
10.90
7.0
3.5
3.97
2.83
mmol/l
0.84
24
48
20
36
5.73
10.77
1.3
1.2
—
—
nmol/l
—
0
0
218
1442
1.87
10.76
4.8
3.5
247.38
159.60
e6/l
0.27
187
1048
47
166
3.01
10.36
7.9
4.3
—
—
—
0
0
137
791
1.99
10.08
1.8
1.7
1.67
1.29
mg/l
0.72
108
608
91
451
2.23
10.01
2.6
1.7
—
—
—
0
0
76
349
2.38
9.98
3.1
2.4
64.20
66.20
g/l
0.98
70
310
78
366
2.33
9.75
3.6
2.3
8.10
7.63
ug/l
0.08
62
315
56
226
2.65
9.64
3.2
2.6
0.23
0.37
e6/l
0.71
56
219
24
58
4.29
9.27
2.6
2.6
—
—
—
0
0
38
128
3.12
9.08
5.8
5.2
—
—
—
0
0
223
1545
1.77
9.05
3.2
2.4
154.15
143.59
ug/l
0.29
205
1393
19
39
5.02
8.90
1.3
1.2
—
—
—
0
0
202
1372
1.76
8.70
3.3
3.1
2.33
2.35
mmol/l
1.35
175
1166
238
1695
1.74
8.66
8.6
5.6
0.51
0.64
%
2.95
220
1562
176
1151
1.79
8.61
4.1
3.0
0.65
0.59
e6/l
0.15
158
888
37
127
3.06
8.57
2.7
3.2
40.06
56.52
mg/l
0.31
31
104
37
127
3.06
8.57
2.7
3.2
61.11
97.18
mg/l
0.32
31
102
261
1911
1.72
8.56
9.0
5.7
0.17
0.20
e9/l
1.14
244
1680
127
753
1.90
8.49
5.4
3.6
172.56
383.11
ng/l
1.19
107
621
244
1757
1.72
8.48
9.7
6.0
7.93
8.90
%
4.73
226
1625
258
1892
1.71
8.35
8.4
5.2
0.00
0.00
estimate
-0.00
63
352
345
2741
1.75
8.31
6.9
4.3
—
—
—
0
0
260
1913
1.71
8.29
6.2
3.9
0.00
0.01
estimate
0.50
61
351
259
1904
1.71
8.28
6.2
3.9
0.00
0.00
estimate
-0.00
71
390
40
147
2.86
8.22
3.2
2.8
4.22
4.37
pmol/l
0.43
32
129
238
1718
1.70
8.09
9.1
6.2
—
—
—
0
0
48
196
2.59
8.08
17.3
7.4
23.97
24.69
mmol/l
0.58
48
181
253
1859
1.69
8.02
8.5
5.5
0.04
0.04
e9/l
1.30
237
1605
252
1851
1.69
7.99
8.9
5.5
0.63
0.61
e9/l
0.46
236
1595
371
3029
1.76
7.89
9.8
7.1
91.23
79.68
u/l
3.10
350
2799
243
1773
1.69
7.87
9.1
5.6
61.93
57.85
%
4.43
225
1647
166
1093
1.76
7.81
4.0
3.0
—
—
—
0
0
256
1897
1.68
7.79
9.0
5.6
1.84
1.94
e9/l
0.31
242
1684
245
1795
1.68
7.78
9.7
5.8
23.40
26.73
%
3.80
228
1658
235
1703
1.68
7.78
2.5
2.0
93.69
95.93
pmol/l
0.28
123
869
240
1749
1.68
7.78
9.0
5.6
2.36
2.85
%
2.40
223
1610
52
227
2.43
7.62
17.8
7.4
92.76
94.14
%
0.56
52
227
283
2182
1.64
7.16
14.7
8.7
5.10
4.18
e9/l
4.18
261
1916
292
2271
1.64
7.12
4.9
3.1
67.94
51.90
u/l
1.71
273
2076
154
1023
1.71
6.89
6.4
3.6
—
—
—
0
0
29
99
3.04
6.80
3.0
3.4
—
—
—
0
0
49
220
2.35
6.75
5.7
4.3
—
—
—
0
0
99
582
1.86
6.68
3.0
2.0
—
—
—
0
0
26
84
3.20
6.68
1.1
1.2
—
—
—
0
0
43
183
2.47
6.66
1.5
1.9
1.62
1.52
g/l
0.29
34
160
154
1033
1.69
6.61
1.9
1.5
19.68
20.15
nmol/l
0.13
139
854
15
23
6.68
6.37
1.1
1.1
2.19
1.92
mmol/l
0.56
15
23
21
61
3.54
6.35
2.6
3.4
57.00
59.77
%
0.36
21
61
75
416
1.94
6.02
2.9
3.3
7.26
10.18
umol/l
1.02
64
363
170
1200
1.61
5.87
4.1
3.5
17.90
7.78
mg/mmol
0.93
118
741
9
7
13.05
5.60
1.2
1.3
194.78
109.38
mmol/24h
—
9
7
230
1773
1.53
5.28
3.3
2.6
—
—
—
0
0
14
26
5.50
5.25
1.2
1.7
—
—
—
0
0
164
1178
1.57
5.16
3.5
2.9
5.64
7.33
mmol/l
7.53
139
973
12
19
6.44
5.10
2.7
1.4
473.20
39.15
umol/l
—
5
13
19
61
3.19
4.96
1.8
2.8
—
—
—
0
0
39
183
2.22
4.89
1.4
1.3
—
—
—
0
0
21
73
2.95
4.82
2.3
2.5
—
—
—
0
0
24
90
2.75
4.81
3.0
2.2
128.29
82.87
ug/min
0.21
17
48
14
30
4.76
4.71
1.4
1.7
—
—
—
0
0
18
58
3.18
4.68
2.2
3.0
4.34
4.71
e9/l
0.27
18
58
38
180
2.20
4.66
6.4
4.9
24.53
25.22
mmol/l
0.68
38
174
44
222
2.07
4.61
5.7
4.2
—
—
—
0
0
152
1097
1.54
4.61
6.4
4.0
0.00
0.00
estimate
-0.00
56
344
58
324
1.89
4.56
2.9
4.4
1.02
0.87
%
0.19
28
121
332
2814
1.48
4.51
5.4
3.6
15.19
15.04
pmol/l
0.42
299
2485
15
37
4.14
4.44
1.3
1.2
—
—
—
0
0
165
1225
1.50
4.35
3.5
2.4
—
—
—
0
0
54
303
1.87
4.20
2.6
2.3
—
—
—
0
0
58
335
1.82
4.12
6.5
3.6
—
—
—
0
0
10
18
5.64
3.99
4.5
2.8
—
—
—
0
0
17
59
2.94
3.93
3.1
2.3
—
—
—
0
0
152
1132
1.48
3.88
3.5
3.0
765.72
300.27
mg/l
0.46
107
719
53
304
1.83
3.86
2.8
4.5
0.09
0.15
%
0.36
23
103
167
1271
1.46
3.81
5.5
3.8
—
—
—
0
0
18
66
2.79
3.79
3.1
2.4
—
—
—
0
0
122
877
1.51
3.68
6.6
4.3
1.02
1.02
kg/l
0.31
22
126
14
45
3.17
3.67
3.4
2.7
—
—
—
0
0
16
57
2.86
3.55
2.9
2.3
—
—
—
0
0
50
291
1.79
3.48
3.2
4.3
0.71
0.48
%
0.33
24
101
23
100
2.36
3.48
1.4
1.4
—
—
—
0
0
127
931
1.48
3.47
10.6
6.1
—
—
—
0
0
134
994
1.47
3.45
2.7
2.7
384.52
8265.48
umol/l
4.89
114
829
16
59
2.77
3.35
3.0
2.3
—
—
—
0
0
22
96
2.35
3.31
1.5
1.3
209.31
294.67
ug/g
1.24
13
58
16
60
2.72
3.25
3.0
2.2
—
—
—
0
0
16
60
2.72
3.25
3.0
2.2
—
—
—
0
0
40
222
1.87
3.25
2.1
2.5
—
—
—
0
0
12
34
3.59
3.21
3.3
2.4
—
—
—
0
0
14
49
2.91
3.21
1.0
1.1
—
—
—
0
0
0
81
0.00
3.16
0.0
1.5
—
—
—
0
0
114
837
1.46
3.07
3.1
3.0
2.47
2.46
mmol/l
0.39
98
718
6
8
7.57
3.06
1.3
1.3
—
—
—
0
0
5
5
10.08
2.98
2.2
2.4
—
—
—
0
0
17
70
2.48
2.90
1.1
1.1
—
—
—
0
0
7
13
5.44
2.87
3.1
2.2
—
—
—
0
0
6
9
6.73
2.87
1.0
1.2
—
—
—
0
0
45
270
1.73
2.86
5.4
3.5
—
—
—
0
0
58
373
1.62
2.85
4.2
3.4
—
—
—
0
0
12
39
3.12
2.78
1.0
1.0
—
—
—
0
0
15
60
2.54
2.72
1.6
2.9
—
—
—
0
0
46
282
1.69
2.71
3.3
4.6
0.18
0.16
%
0.05
17
83
9
24
3.80
2.68
1.9
4.1
—
—
—
0
0
119
903
1.41
2.67
6.4
3.8
80.97
86.21
%
1.28
113
882
87
626
1.47
2.59
1.4
1.4
3.05
2.74
g/l
0.46
55
355
7
16
4.42
2.48
1.7
1.3
—
—
—
0
0
7
16
4.42
2.48
1.3
1.3
—
—
—
0
0
416
3844
1.39
2.45
35.9
14.6
30.83
26.61
mg/l
1.73
395
3067
8
22
3.68
2.37
1.3
1.2
99.13
84.82
umol/l
—
8
22
61
417
1.52
2.33
1.7
1.7
—
—
—
0
0
22
114
1.97
2.23
1.4
1.2
—
—
—
0
0
14
60
2.37
2.23
3.3
2.2
—
—
—
0
0
9
29
3.14
2.23
1.3
1.4
—
—
—
0
0
5
9
5.60
2.22
1.8
1.7
—
—
—
0
0
63
876
0.68
2.17
2.4
3.1
0.78
0.80
ug/l
0.05
43
604
64
450
1.48
2.15
1.3
1.3
388.57
443.60
titre
—
7
100
350
3797
0.77
2.13
5.3
4.8
2.28
2.69
mmol/l
15.35
318
3376
8
25
3.23
2.10
1.0
1.0
—
—
—
0
0
87
652
1.40
2.09
3.6
2.8
2.38
2.27
e6/l
0.05
62
368
377
3465
1.31
2.06
6.2
4.4
1.76
2.03
mu/l
3.97
339
3081
7
20
3.53
2.06
1.7
1.4
—
—
—
0
0
7
20
3.53
2.06
1.1
1.1
50.00
30.57
mg/l
—
7
14
6
15
4.03
2.04
1.3
1.3
—
—
—
0
0
24
133
1.84
2.03
3.9
3.0
0.70
0.89
nmol/l
1.70
18
105
7
21
3.36
1.97
1.3
1.3
—
—
—
0
0
12
51
2.38
1.96
3.5
2.0
—
—
—
0
0
341
3697
0.78
1.95
4.9
4.3
4.14
4.60
mmol/l
13.52
312
3321
10
39
2.59
1.95
1.9
2.5
5.37
3.52
nmol/l
—
10
39
8
27
2.99
1.94
2.5
2.6
—
—
—
0
0
8
27
2.99
1.94
1.3
1.3
—
—
—
0
0
11
45
2.48
1.94
1.2
1.3
—
—
—
0
0
9
33
2.76
1.94
1.1
1.8
—
—
—
0
0
337
3656
0.78
1.92
4.9
4.2
1.36
1.48
mmol/l
4.07
309
3252
317
2866
1.27
1.89
4.7
4.1
19.15
13.74
mm/h
5.07
292
2611
52
361
1.49
1.88
1.5
1.5
—
—
—
0
0
5
12
4.20
1.82
3.0
2.3
33760.00
38033.33
ug/l
—
5
12
47
322
1.50
1.81
1.4
1.5
—
—
—
0
0
7
23
3.07
1.80
2.0
4.4
—
—
—
0
0
109
869
1.32
1.77
5.2
4.0
—
—
—
0
0
7
24
2.94
1.72
4.6
1.3
13.57
8.65
mmol/l
—
7
24
67
498
1.40
1.70
1.4
1.2
—
—
—
0
0
7
25
2.82
1.65
1.4
1.3
—
—
—
0
0
5
15
3.35
1.52
1.0
1.1
155.60
129.40
nmol/l
—
5
15
59
439
1.39
1.51
6.6
3.9
—
—
—
0
0
6
21
2.88
1.51
1.2
2.2
47.65
36.48
%
—
6
21
13
65
2.03
1.50
1.2
1.3
316.88
305.58
u/ml
—
8
40
26
165
1.61
1.43
1.2
1.2
44.87
121.74
iu/ml
—
8
67
89
712
1.30
1.42
1.3
1.2
2.55
1.43
u/ml
0.29
26
170
190
1663
1.22
1.41
19.7
9.6
0.00
0.00
e9/l
1.03
174
1363
11
53
2.10
1.39
1.0
1.2
—
—
—
0
0
24
151
1.62
1.37
1.1
1.1
—
33.00
—
0
5
129
1514
0.80
1.36
1.9
2.2
—
—
—
0
0
46
335
1.41
1.34
2.7
2.4
45.53
33.29
u/l
0.33
38
280
427
4070
1.26
1.27
46.2
16.9
3.97
3.99
mmol/l
0.95
420
3933
426
4061
1.25
1.26
47.6
16.8
140.01
139.73
mmol/l
0.42
418
3925
57
437
1.34
1.24
1.8
1.5
—
—
—
0
0
11
56
1.98
1.23
1.1
1.6
—
—
—
0
0
5
19
2.65
1.22
1.6
1.4
0.13
0.18
nmol/l
—
5
11
35
248
1.44
1.20
10.5
3.0
4.74
5.91
e9/l
0.41
24
188
8
38
2.12
1.19
1.1
1.3
—
—
—
0
0
5
20
2.51
1.15
1.0
1.5
—
—
—
0
0
10
52
1.94
1.06
1.1
1.4
—
—
—
0
0
5
22
2.28
1.03
1.6
1.1
—
—
—
0
0
334
3532
0.85
1.00
4.5
3.8
1.41
1.25
mmol/l
3.03
307
3115
31
421
0.72
0.99
1.6
1.3
—
—
—
0
0
5
23
2.18
0.98
4.6
2.1
551.60
494.23
min
—
5
13
9
50
1.81
0.97
1.0
1.1
—
—
—
0
0
9
52
1.74
0.92
1.2
1.1
—
—
—
0
0
6
28
2.16
0.91
1.0
1.1
—
—
—
0
0
14
86
1.65
0.91
1.4
1.3
—
—
—
0
0
56
454
1.26
0.85
3.2
4.0
23.71
34.76
ug/l
0.21
48
382
23
319
0.71
0.85
2.1
1.5
—
—
—
0
0
24
329
0.72
0.83
1.5
1.5
—
—
—
0
0
11
66
1.68
0.79
1.6
1.4
—
—
—
0
0
6
34
1.77
0.76
2.3
2.4
—
—
—
0
0
10
59
1.71
0.76
1.8
1.4
—
—
—
0
0
10
59
1.71
0.76
1.5
1.5
—
—
—
0
0
9
54
1.68
0.75
2.3
4.5
—
—
—
0
0
5
25
2.01
0.73
1.0
1.0
—
—
—
0
0
5
26
1.93
0.71
5.4
2.7
—
—
—
0
0
82
940
0.85
0.67
2.0
1.6
1.58
1.29
mmol/l
1.26
67
756
22
162
1.37
0.67
1.8
2.9
0.14
0.23
g/l
1.16
11
62
10
62
1.62
0.65
1.9
2.1
51.20
62.18
%
—
10
62
412
3993
1.14
0.62
33.9
14.0
—
—
—
0
0
0
21
0.00
0.60
0.0
1.0
—
—
—
0
0
41
495
0.81
0.59
1.4
1.3
—
—
—
0
0
47
555
0.83
0.55
1.4
1.2
16.31
12.91
u/ml
0.12
21
204
21
160
1.33
0.54
2.0
1.9
—
—
—
0
0
102
918
1.14
0.53
1.3
1.3
—
—
—
0
0
27
217
1.26
0.49
1.4
1.4
—
—
—
0
0
7
109
0.64
0.49
1.1
1.1
—
—
—
0
0
334
3227
1.10
0.44
41.4
17.1
15.13
15.48
%
0.70
329
3154
0
15
0.00
0.41
0.0
1.4
—
—
—
0
0
11
79
1.40
0.41
1.6
1.8
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
9
68
1.33
0.37
1.1
1.6
—
—
—
0
0
44
386
1.15
0.35
2.2
2.0
176.16
147.06
ug/g
0.16
32
300
14
108
1.30
0.35
1.7
1.5
—
—
—
0
0
6
45
1.34
0.34
1.3
1.4
—
—
—
0
0
12
92
1.31
0.32
1.8
1.6
3098.67
11285.20
e6/l
—
6
65
318
3096
1.07
0.29
45.8
19.2
328.28
331.78
g/l
6.85
313
3059
38
336
1.14
0.29
1.4
1.4
—
—
—
0
0
52
574
0.90
0.29
1.3
1.3
18.86
42.87
iu/ml
2.98
14
175
19
158
1.21
0.28
1.3
1.5
—
—
—
0
0
106
1128
0.92
0.28
4.0
2.9
—
—
—
0
0
12
95
1.27
0.26
3.8
2.6
—
—
—
0
0
9
72
1.25
0.25
2.2
1.6
—
—
—
0
0
431
4254
1.07
0.22
49.7
21.4
7.75
6.82
e9/l
10.49
421
4097
28
248
1.14
0.22
1.2
1.1
—
—
—
0
0
21
182
1.16
0.21
2.8
3.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.5
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
8.11
—
0
13
430
4252
1.06
0.18
49.5
21.4
244.63
240.98
e9/l
0.49
421
4114
430
4252
1.06
0.18
49.3
21.2
30.21
30.36
pg
0.86
424
4151
430
4252
1.06
0.18
49.4
21.3
91.77
91.42
fl
0.79
424
4152
430
4253
1.06
0.18
49.6
21.4
4.19
4.44
e12/l
16.70
420
4094
430
4253
1.06
0.18
50.2
21.3
36.98
39.69
%
8.24
383
3911
430
4254
1.06
0.17
50.1
21.5
125.93
133.99
g/l
20.35
424
4149
24
215
1.12
0.17
2.0
2.5
—
21.39
—
0
11
8
68
1.18
0.16
1.5
1.9
183.50
237.89
pmol/l
—
8
63
15
171
0.87
0.15
1.1
1.3
—
—
—
0
0
10
117
0.85
0.13
11.8
11.0
—
—
—
0
0
21
192
1.10
0.11
1.1
1.3
—
51.48
—
0
12
14
125
1.12
0.10
4.5
3.2
—
—
—
0
0
5
45
1.11
0.10
5.4
2.6
—
—
—
0
0
155
1523
1.03
0.07
3.7
5.2
2.10
2.93
ug/l
1.52
139
1339
6
75
0.80
0.07
1.7
1.4
—
—
—
0
0
17
184
0.92
0.07
1.2
1.4
—
—
—
0
0
27
285
0.94
0.06
1.7
1.4
—
—
—
0
0
411
4087
1.03
0.06
14.6
10.1
29.81
25.08
u/l
0.83
394
3887
270
2726
0.98
0.06
5.5
3.9
—
—
—
0
0
20
210
0.95
0.03
1.1
1.3
—
—
—
0
0
372
3733
0.99
0.02
5.5
4.7
6.44
6.00
mmol/l
5.54
329
3298
357
3578
0.99
0.01
9.0
5.7
44.03
40.17
mmol/mol
6.80
334
3236
17
176
0.96
0.00
2.4
1.3
789.73
215.20
u/ml
0.57
17
160
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

↥

Association

Association between endpoint E4_HYPEROSMHNAT and mortality.

Females

Parameter HR [95% CI] p-value
E4_HYPEROSMHNAT 2.976 [2.48, 3.57] < 0.001
Birth year 0.994 [0.98, 1.0] 0.197

During the follow-up period (1.1.1998 — 31.12.2019), 1646 out of 2715 females with E4_HYPEROSMHNAT died.

Males

Parameter HR [95% CI] p-value
E4_HYPEROSMHNAT 4.461 [3.18, 6.26] < 0.001
Birth year 0.986 [0.98, 1.0] 0.003

During the follow-up period (1.1.1998 — 31.12.2019), 1063 out of 1820 males with E4_HYPEROSMHNAT died.

Mortality risk

Mortality risk for people of age

years, who have E4_HYPEROSMHNAT.

N-year risk Females Males
1 0.292% 0.98%
5 1.729% 5.517%
10 4.226% 12.168%
15 8.068% 21.54%
20 13.518% 34.209%

Relationships between endpoints

↥

Index endpoint: E4_HYPEROSMHNAT – Hyperosmolality and hypernatraemia

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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