No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
468 |
4. Check minimum number of eventsNone |
468 |
5. Include endpointsNone |
468 |
6. Filter based on genotype QC (FinnGen only) |
468 |
Control definitions (FinnGen only)
- Control exclude
- E4_METABOLIA
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- E87
- Name in latin
- Hyperosmolalitas
Similar endpoints
↥List of similar endpoints to
Hyperosmolality and hypernatraemia
based on the number of shared cases.
Similar with more cases:
- Other disorders of fluid, electrolyte and acid-base balance
- Metabolic disorders
- Endocrine, nutritional and metabolic diseases
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 6622 | 3751 | 2831 |
| Only index persons | 5696 | 3249 | 2447 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.09 | 0.11 | 0.08 |
| Only index persons | 0.11 | 0.12 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 77.28 | 80.01 | 73.68 |
| Only index persons | 77.45 | 80.17 | 73.85 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 468 | 214 | 254 |
| Unadjusted period prevalence (%) | 0.09 | 0.07 | 0.11 |
| Median age at first event (years) | 71.36 | 71.22 | 71.48 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 424
- Matched controls
- 4238
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
E87.0
ICD-10 Finland
Hyperosmolality and hypernatraemia
4503599627370496.0
323.0
421
*
E87.1
ICD-10 Finland
Hypo-osmolality and hyponatraemia
135.5
99.1
103
10
E86
ICD-10 Finland
Volume depletion
164.0
55.3
57
*
E87.6
ICD-10 Finland
Hypokalaemia
45.3
42.7
52
13
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.6
36.7
153
460
J18.9
ICD-10 Finland
Pneumonia, unspecified
3.4
28.9
191
822
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.2
28.7
127
391
AA1AD
NOMESCO Finland
CT of head and brain
3.5
28.3
169
670
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
6.6
28.0
76
135
N05AX08
ATC
risperidone; systemic
5.3
27.8
93
214
N05AA02
ATC
levomepromazine; systemic
9.3
26.3
56
68
N05AH03
ATC
olanzapine; systemic
8.0
25.5
60
86
N03AG01
ATC
valproic acid; systemic, rectal
7.5
25.2
62
95
R53
ICD-10 Finland
Malaise and fatigue
3.4
24.7
145
555
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
4.1
24.6
109
330
N05AN01
ATC
lithium; oral
15.6
24.4
40
28
A49.9
ICD-10 Finland
Bacterial infection, unspecified
4.0
21.8
97
292
N05AH04
ATC
quetiapine; oral
3.8
21.8
105
339
E87.5
ICD-10 Finland
Hyperkalaemia
63.4
21.1
24
*
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.7
20.8
101
327
N05BA04
ATC
oxazepam; oral
3.0
20.5
146
626
A06AD11
ATC
lactulose; oral
3.3
20.5
123
469
A28
ICPC
Limited function/disability NOS
3.3
20.0
119
449
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.9
19.5
148
658
N17.9
ICD-10 Finland
Acute renal failure, unspecified
7.9
19.1
44
61
E23.2
ICD-10 Finland
Diabetes insipidus
73.3
18.9
21
*
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.7
18.7
177
897
R41.0
ICD-10 Finland
Disorientation, unspecified
6.5
18.5
49
83
L28
ICPC
Limited function/disability (L)
3.2
18.3
112
430
G72.8
ICD-10 Finland
Other specified myopathies
13.9
17.7
30
23
C03CA01
ATC
furosemide; systemic
2.5
17.7
194
1061
T36
ICD-10 Finland
Poisoning by systemic antibiotics
7.8
17.2
40
56
102
Kela drug reimbursment
Diabetes insipidus
66.1
16.9
19
*
103
Kela drug reimbursment
Diabetes, insulin-treated
2.6
16.9
156
769
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
12.3
16.8
30
26
N05BA06
ATC
lorazepam; systemic, sublingual
5.3
16.8
53
112
N05AF03
ATC
chlorprothixene; systemic
11.4
16.7
31
29
N05CD07
ATC
temazepam; oral
3.2
16.7
100
374
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
6.2
16.6
45
79
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
5.2
16.4
52
110
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
4.5
16.1
59
146
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
12.9
16.1
28
23
R56.8
ICD-10 Finland
Other and unspecified convulsions
5.7
15.7
46
89
H02AB09
ATC
hydrocortisone; systemic
15.5
15.5
25
17
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
3.9
15.5
68
199
N06AB04
ATC
citalopram; systemic
2.8
15.5
115
494
E78.01
ICD-10 Finland
Pure hypercholesterolaemia
3.7
15.3
70
213
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.4
15.0
81
277
N05AX12
ATC
aripiprazole; systemic
11.0
14.9
28
27
E78.00
ICD-10 Finland
Familial hypercholesterolaemia
58.8
14.9
17
*
N05AA01
ATC
chlorpromazine; systemic, rectal
20.9
13.9
20
10
E23.00
ICD-10 Finland
Panhypopituitarism
77.7
13.7
15
*
E78.5
ICD-10 Finland
Hyperlipidaemia, unspecified
7.1
13.6
33
50
SPAT1234
SPAT
Support of social functional capacity
4.6
13.5
48
115
F31.6
ICD-10 Finland
Bipolar affective disorder, current episode mixed
19.0
13.5
20
11
F25.9
ICD-10 Finland
Schizoaffective disorder, unspecified
19.0
13.5
20
11
SPAT1254
SPAT
Administration of medicine
2.8
13.3
93
382
I50.9
ICD-10 Finland
Heart failure, unspecified
2.7
13.1
105
468
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
7.0
13.1
32
49
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.5
13.0
120
577
G40.9
ICD-10 Finland
Epilepsy, unspecified
6.8
12.9
32
50
ZXD05
NOMESCO Finland
Urgent procedure
2.3
12.8
148
799
N25.1
ICD-10 Finland
Nephrogenic diabetes insipidus
+∞
12.6
12
*
A10AE04
ATC
insulin glargine; parenteral
3.5
12.5
61
195
A10BA02
ATC
metformin; oral
2.3
12.2
148
812
N05AH02
ATC
clozapine; systemic
12.9
12.2
21
17
N05BA01
ATC
diazepam; systemic, rectal
2.9
12.1
80
315
F31.1
ICD-10 Finland
Bipolar affective disorder, current episode manic without psychotic symptoms
22.1
12.1
17
8
F20.9
ICD-10 Finland
Schizophrenia, unspecified
9.3
11.9
24
27
F31.0
ICD-10 Finland
Bipolar affective disorder, current episode hypomanic
15.2
11.9
19
13
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
3.8
11.8
51
147
F10.25
ICD-10 Finland
Alcohol dependence continuous use
11.0
11.4
21
20
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.6
11.3
92
408
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
4.2
11.3
43
111
N30.0
ICD-10 Finland
Acute cystitis
2.9
11.2
74
289
R50.9
ICD-10 Finland
Fever, unspecified
2.9
11.2
74
291
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
11.2
83
349
N03AX09
ATC
lamotrigine; oral
7.0
11.2
27
41
N05AC02
ATC
thioridazine; oral
7.7
11.1
25
34
P20
ICPC
Memory disturbance
2.7
11.1
84
360
G30.9
ICD-10 Finland
Alzheimer disease, unspecified
4.3
11.1
41
103
A04
ICPC
Weakness/tiredness general
2.9
11.0
73
285
N03AF02
ATC
oxcarbazepine; oral
8.1
11.0
24
31
E83.50
ICD-10 Finland
Hypercalcemia
44.5
11.0
13
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
2.6
10.8
84
362
N05AB03
ATC
perphenazine; systemic, rectal
5.5
10.7
31
60
307
Kela drug reimbursment
Tacrine, donepezil, rivastigmine, galantamine and other major and expensive drugs used to treat Alzheimer's disease
3.3
10.5
53
174
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
6.3
10.5
27
45
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
3.4
10.3
50
159
A41.9
ICD-10 Finland
Sepsis, unspecified
4.9
10.2
33
72
F31.7
ICD-10 Finland
Bipolar affective disorder, currently in remission
13.6
10.2
17
13
Z76.8
ICD-10 Finland
Persons encountering health services in other specified circumstances
7.2
10.2
24
35
N05AD01
ATC
haloperidol; systemic
5.0
10.2
32
68
F03
ICD-10 Finland
Unspecified dementia
3.8
10.1
43
123
N04AA02
ATC
biperiden; systemic
7.9
10.0
22
29
N06AX11
ATC
mirtazapine; oral
2.1
10.0
140
806
N05AF05
ATC
zuclopenthixol; systemic
12.6
9.9
17
14
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.4
9.7
90
425
F10.29
ICD-10 Finland
Addiction caused by alcohol UNS
8.1
9.7
21
27
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
9.4
9.6
19
21
SPAT1137
SPAT
Taking care of patient’s/customer’s hygiene
3.3
9.6
49
162
N06DX01
ATC
memantine; oral
3.0
9.4
57
211
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
9.4
61
237
G30.1
ICD-10 Finland
Alzheimer disease with late onset
3.0
9.4
55
201
N03AF01
ATC
carbamazepine; oral, rectal
4.0
9.2
36
96
F20.00
ICD-10 Finland
Paranoid schizophrenia continuous
10.4
9.1
17
17
C07AB07
ATC
bisoprolol; oral
1.9
9.1
225
1594
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
2.9
9.0
55
204
SPAT1245
SPAT
Provision of support and information to patient’s family members
3.8
9.0
38
108
A10BH01
ATC
sitagliptin; oral
3.0
9.0
53
194
F10.21
ICD-10 Finland
Alcohol dependence currently abstinent, but staying in restrictive environment
24.6
9.0
12
5
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.6
8.9
39
115
R11
ICD-10 Finland
Nausea and vomiting
3.1
8.9
50
177
F31.30
ICD-10 Finland
Bipolar disorder Depressive episode without somatic syndrome
11.0
8.9
16
15
I10
ICD-10 Finland
Essential (primary) hypertension
1.9
8.8
269
2034
F25.20
ICD-10 Finland
Schizoaffective syndrome, mixed type with only concomitant bipolar and schizophrenic symptoms
51.0
8.7
10
*
E11.00
ICD-10 Finland
Non-insulin dependent diabetes diabetic hypoglycaemic coma
4.1
8.7
33
86
101
Kela drug reimbursment
Anterior pituitary hypofunction
16.7
8.6
13
8
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.4
8.6
76
349
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.4
8.5
41
130
F25.00
ICD-10 Finland
Schizoaffective syndrome, manic type with only simultaneous bipolar and schizophrenic symptoms
28.1
8.5
11
*
E87.8
ICD-10 Finland
Other disorders of electrolyte and fluid balance, not elsewhere classified
91.8
8.4
9
*
F05.9
ICD-10 Finland
Delirium, unspecified
5.7
8.4
23
42
SPAT1263
SPAT
Sampling
1.9
8.3
178
1183
E78.9
ICD-10 Finland
Disorder of lipoprotein metabolism, unspecified
9.7
8.3
16
17
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
7.3
8.3
19
27
SPAT1262
SPAT
Handing over of treatment supplies
2.2
8.3
90
459
C08CA01
ATC
amlodipine; oral
1.9
8.3
175
1162
N05CF01
ATC
zopiclone; oral
1.9
8.2
154
978
I50.0
ICD-10 Finland
Congestive heart failure
2.7
8.2
55
219
F32.9
ICD-10 Finland
Depressive episode, unspecified
3.1
8.1
45
157
SPAT1216
SPAT
Assessment of functional ability
2.2
8.0
84
423
P99
ICPC
Psychological disorders other
8.0
7.9
17
22
R33
ICD-10 Finland
Retention of urine
2.8
7.9
53
209
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.6
7.9
59
248
F31.2
ICD-10 Finland
Bipolar affective disorder, current episode manic with psychotic symptoms
45.8
7.7
9
*
R55
ICD-10 Finland
Syncope and collapse
2.5
7.7
63
278
AA400
NOMESCO Finland
Electroconvulsive therapy
18.8
7.6
11
6
F31
ICD-10 Finland
Bipolar affective disorder
18.8
7.6
11
6
2957A
ICD-9 Finland
Schizophrenic psychoses, Schizo-affective type
25.5
7.6
10
*
F10.09
ICD-10 Finland
Alcohol intoxication UNS
9.1
7.6
15
17
188
Kela drug reimbursment
Psychosis requiring demanding treatment
10.3
7.6
14
14
N06AB03
ATC
fluoxetine; oral
2.7
7.6
54
221
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.6
7.5
33
98
N05BA02
ATC
chlordiazepoxide; systemic
5.8
7.5
20
36
9690A
ICD-9 Finland
Poisoning by psychotropic agents, Antidepressants
81.4
7.4
8
*
F31.4
ICD-10 Finland
Bipolar affective disorder, current episode severe depression without psychotic symptoms
13.7
7.4
12
9
E87.2
ICD-10 Finland
Acidosis
+∞
7.3
7
*
F31.20
ICD-10 Finland
Bipolar disorder, manic episode with mood-congruent psychotic symptoms
16.1
7.3
11
7
N03AX14
ATC
levetiracetam; systemic
5.5
7.2
20
38
SPAT1301
SPAT
No procedures
1.8
7.2
146
943
29570
ICD-8 Finland
Schizophrenia, Schizo-affective type
20.4
7.2
10
5
P29
ICPC
Psychological sympt/compl other
4.5
7.1
24
56
Y94.0
ICD-10 Finland
Accident at home
5.8
7.1
19
34
K59.09
ICD-10 Finland
Constipation, unspecified
3.3
7.1
34
108
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
3.5
7.1
32
97
F10.40
ICD-10 Finland
Withdrawal symptoms and delirium caused by alcohol without seizures
9.0
7.1
14
16
F10.24
ICD-10 Finland
Alcohol depence active use
10.3
7.1
13
13
E950A
ICD-9 Finland
Suicide and self-inflicted poisoning by solid or liquid substances
10.3
7.1
13
13
N06AA12
ATC
doxepin; systemic
3.1
7.0
37
127
R73.9
ICD-10 Finland
Hyperglycaemia, unspecified
5.6
7.0
19
35
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
7.7
7.0
15
20
H02AA02
ATC
fludrocortisone; oral
9.5
6.8
13
14
A10AE05
ATC
insulin detemir; parenteral
3.5
6.8
30
90
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
1.8
6.7
124
775
S06.0
ICD-10 Finland
Concussion
2.5
6.7
50
213
S97
ICPC
Chronic ulcer skin
3.2
6.6
33
109
J01EA01
ATC
trimethoprim; systemic
1.9
6.6
111
669
N06AB06
ATC
sertraline; oral
2.7
6.6
45
180
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.9
6.6
111
673
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.8
6.5
127
803
N30.9
ICD-10 Finland
Cystitis, unspecified
3.2
6.5
33
110
A10BH05
ATC
linagliptin; oral
3.3
6.5
31
99
F29
ICD-10 Finland
Unspecified nonorganic psychosis
4.8
6.5
20
43
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
6.4
63
307
F10.20
ICD-10 Finland
Alcohol dependence currently independent
6.7
6.4
15
23
F00.10*G30.1
ICD-10 Finland
Primary degenerative dementia of the Alzheimer's type, senile onset without additional symptoms
3.3
6.4
30
95
N06AX16
ATC
venlafaxine; oral
2.5
6.4
48
205
D64.9
ICD-10 Finland
Anaemia, unspecified
2.3
6.4
56
259
UKC02
NOMESCO Finland
Cystoscopy
2.0
6.3
80
435
E000001
ATC
NA
2.0
6.3
89
505
E83.51
ICD-10 Finland
Hypocalcemia
+∞
6.3
6
*
SPAT1309
SPAT
Guidance related to psychoactive substances / risk behaviour
6.4
6.2
15
24
T90
ICPC
Diabetes non-insulin dependent
1.9
6.2
97
570
N05BE01
ATC
buspirone; oral
4.4
6.2
21
50
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
6.2
76
408
N07BB01
ATC
disulfiram; oral
4.8
6.2
19
41
Z02.4
ICD-10 Finland
Examination for driving licence
0.4
6.2
36
737
SPAT1229
SPAT
Assessment of need for aid
2.5
6.1
47
203
N02BE01
ATC
paracetamol; systemic, rectal
1.8
6.1
343
2953
P16
ICPC
Acute alcohol abuse
8.8
6.1
12
14
WX872
NOMESCO Finland
Intensive care
3.2
6.0
29
94
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
6.0
76
410
Mortality – FinRegistry
↥Association
Association between endpoint E4_HYPEROSMHNAT and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPEROSMHNAT | 2.976 [2.48, 3.57] | < 0.001 |
| Birth year | 0.994 [0.98, 1.0] | 0.197 |
During the follow-up period (1.1.1998 — 31.12.2019), 1646 out of 2715 females with E4_HYPEROSMHNAT died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| E4_HYPEROSMHNAT | 4.461 [3.18, 6.26] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 1063 out of 1820 males with E4_HYPEROSMHNAT died.
Mortality risk
Mortality risk for people of age
years, who have E4_HYPEROSMHNAT.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.292% | 0.98% |
| 5 | 1.729% | 5.517% |
| 10 | 4.226% | 12.168% |
| 15 | 8.068% | 21.54% |
| 20 | 13.518% | 34.209% |
Relationships between endpoints
↥Index endpoint: E4_HYPEROSMHNAT – Hyperosmolality and hypernatraemia
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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