Risteys · G6_POSTZOST

Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — G53.0, G53.0B02.20, G53.0B02.21 Cause of death:* ICD-10 — G53.0, G53.0B02.20, G53.0*B02.21 2 out of 7 registries used, show all original rules.	508
4. Check minimum number of events None	508
5. Include endpoints None	508
6. Filter based on genotype QC (FinnGen only)	508

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3542	2189	1325
Only index persons	3234	2038	1196
Unadjusted period prevalence (%)
Whole population	0.05	0.06	0.04
Only index persons	0.06	0.07	0.05
Median age at first event (years)
Whole population	75.27	76.62	72.99
Only index persons	74.95	76.35	72.58

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	508	295	213
Unadjusted period prevalence (%)	0.10	0.10	0.09
Median age at first event (years)	72.36	71.95	72.92

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

↥

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
440: Matched controls
4402

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

G53.0

ICD-10 Finland

Postzoster neuralgia

443.5

212.5

197

G53.0*B02.20

ICD-10 Finland

Trigeminal neuralgia after shingles

+∞

184.8

164

B02.9

ICD-10 Finland

Zoster without complication

20.8

119.3

190

155

N03AX16

ATC

pregabalin; oral

10.2

103.9

271

598

N03AX12

ATC

gabapentin; oral

12.1

102.8

220

336

G53.0*B02.21

ICD-10 Finland

Postherpetic geniculate ganglionitis

1141.1

96.8

J05AB11

ATC

valaciclovir; oral

11.5

95.6

208

319

J05AB01

ATC

aciclovir; systemic

9.1

91.4

245

533

G530, B028

ICD-10 Finland

+∞

55.4

N02AX02

ATC

tramadol; systemic, rectal

5.0

54.8

293

1251

B02.8

ICD-10 Finland

Zoster with other complications

50.2

47.6

B02

ICD-10 Finland

Zoster [herpes zoster]

12.3

44.6

S70

ICPC

Herpes zoster

12.4

32.1

G50.0

ICD-10 Finland

Trigeminal neuralgia

118.6

31.1

N03AF01

ATC

carbamazepine; oral, rectal

7.8

29.1

104

N06AX21

ATC

duloxetine; oral

5.7

28.8

186

N06AA09

ATC

amitriptyline; systemic

5.3

27.2

203

G56.0

ICD-10 Finland

Carpal tunnel syndrome

13.8

26.5

H02AB06

ATC

prednisolone; systemic

3.0

26.2

260

1440

N02AA05

ATC

oxycodone; systemic

3.6

23.9

127

446

N02AA59

ATC

codeine, combinations excl. psycholeptics; systemic

2.8

23.6

239

1307

N02AE01

ATC

buprenorphine; parenteral, sublingual, transdermal

3.6

22.6

120

419

B02.20

ICD-10 Finland

Herpes zoster trigeminal neuralgia

84.5

21.9

A02BC02

ATC

pantoprazole; systemic

2.7

20.2

325

2237

N02AJ06

ATC

codeine and paracetamol; systemic

2.7

20.1

188

952

B02.21

ICD-10 Finland

Herpes zoster neuralgia in another cranial nerve

+∞

19.9

R10.4

ICD-10 Finland

Other and unspecified abdominal pain

2.7

19.8

182

906

R51.80

ICD-10 Finland

Headache

3.8

19.8

291

G51.0

ICD-10 Finland

Bell palsy

110.0

19.7

GD1AA

NOMESCO Finland

Thorax X-ray examination

2.5

18.8

243

1454

J01DB01

ATC

cefalexin; oral

3.0

18.7

370

2807

M79.6

ICD-10 Finland

Pain in limb

2.6

18.6

185

958

H19.2*B02.3

ICD-10 Finland

Keratitis and keratoconjunctivitis (interstitial) in zoster

34.6

18.1

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

2.6

17.5

175

900

Z01.0

ICD-10 Finland

Examination of eyes and vision

3.2

17.3

104

391

B02.3

ICD-10 Finland

Zoster ocular disease

31.4

16.3

G530, B029

ICD-10 Finland

+∞

15.7

M79.2

ICD-10 Finland

Neuralgia and neuritis, unspecified

10.6

15.7

M54.5

ICD-10 Finland

Low back pain

2.5

15.6

161

831

N06AX16

ATC

venlafaxine; oral

3.5

15.4

257

R50.9

ICD-10 Finland

Fever, unspecified

3.3

15.1

290

R07.4

ICD-10 Finland

Chest pain, unspecified

2.4

14.9

156

809

N02BE01

ATC

paracetamol; systemic, rectal

3.1

14.9

394

3232

J20.9

ICD-10 Finland

Acute bronchitis, unspecified

2.8

14.5

110

474

N03AX09

ATC

lamotrigine; oral

8.1

14.4

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

3.0

13.9

326

S01AD03

ATC

aciclovir; ophthalmic

5.5

13.7

R53

ICD-10 Finland

Malaise and fatigue

2.5

13.7

127

612

H03.1*B02.3

ICD-10 Finland

Zoster blepharitis

77.6

13.7

A49.9

ICD-10 Finland

Bacterial infection, unspecified

3.2

13.6

274

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

2.3

13.5

173

982

A01

ICPC

Pain general/multiple sites

3.6

13.4

201

A02BC05

ATC

esomeprazole; systemic

2.2

13.3

201

1223

R06.0

ICD-10 Finland

Dyspnoea

2.4

13.3

143

744

J01EE01

ATC

sulfamethoxazole and trimethoprim; systemic

4.2

13.2

133

G44.2

ICD-10 Finland

Tension-type headache

3.2

13.0

259

M51.1

ICD-10 Finland

Lumbar and other intervertebral disc disorders with radiculopathy

3.1

12.9

266

J18.9

ICD-10 Finland

Pneumonia, unspecified

2.3

12.9

154

838

UJD10

NOMESCO Finland

Esophagoscopy, gastroscopy and duodenoscopy

2.3

12.6

152

831

G63.0*B02.29

ICD-10 Finland

Postherpetic polyneuropathy

133.7

12.5

R10.1

ICD-10 Finland

Pain localized to upper abdomen

2.7

12.5

389

G50.1

ICD-10 Finland

Atypical facial pain

18.7

12.1

ZX120

NOMESCO Finland

Intravenous

3.3

12.0

212

L28

ICPC

Limited function/disability (L)

2.5

11.9

108

509

M51.3

ICD-10 Finland

Other specified intervertebral disc degeneration

4.2

11.9

115

Z01.8

ICD-10 Finland

Other specified special examinations

2.4

11.5

110

532

M03BX02

ATC

tizanidine; oral

2.0

11.5

247

1707

J01AA02

ATC

doxycycline; systemic

2.2

11.5

346

2743

ACC51

NOMESCO Finland

Release of median nerve

36.1

11.3

M25.5

ICD-10 Finland

Pain in joint

2.3

11.0

121

628

117

Kela drug reimbursment

Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue

4.5

11.0

DM1QA

NOMESCO Finland

Paranasal sinuses X-ray examination in one projection

5.1

10.9

R03AC02

ATC

salbutamol; inhalant

2.0

10.9

225

1517

J32.0

ICD-10 Finland

Chronic maxillary sinusitis

4.0

10.9

120

A02BC01

ATC

omeprazole; systemic

2.1

10.8

146

828

J01.0

ICD-10 Finland

Acute maxillary sinusitis

2.5

10.8

442

H22.0*B02.3

ICD-10 Finland

Zoster iridocyclitis

61.5

10.7

R52.2

ICD-10 Finland

Other chronic pain

6.3

10.5

GD1QA

NOMESCO Finland

Supine thorax X-ray examination

2.3

10.5

104

513

G530, B022

ICD-10 Finland

+∞

10.5

N01

ICPC

Headache

3.5

10.5

157

R11

ICD-10 Finland

Nausea and vomiting

3.2

10.4

192

L03

ICPC

Low back symptom/complaint

2.2

9.7

111

581

Z03.9

ICD-10 Finland

Observation for suspected disease or condition, unspecified

2.4

9.7

426

AA1AD

NOMESCO Finland

CT of head and brain

2.1

9.7

132

749

S01

ICPC

Pain/tenderness of skin

4.4

9.6

AA1CG

NOMESCO Finland

Extensive MRI examination of brain with high intensity magnet

3.4

9.6

145

R10.3

ICD-10 Finland

Pain localized to other parts of lower abdomen

2.4

9.6

431

WZC00

NOMESCO Finland

Planning of intervention or health care consultation

2.0

9.4

146

872

R05

ICD-10 Finland

Cough

2.3

9.3

472

H04.10

ICD-10 Finland

Dry eye syndrome

2.9

9.3

213

J01FA10

ATC

azithromycin; systemic

1.9

9.1

221

1546

DM1AA

NOMESCO Finland

Paranasal sinuses X-ray examination without contrast

5.5

9.1

N05CF01

ATC

zopiclone; oral

1.9

8.9

163

1029

M01AH05

ATC

etoricoxib; oral

1.8

8.9

232

1658

C03CA01

ATC

furosemide; systemic

1.9

8.9

183

1207

Z00.4

ICD-10 Finland

General psychiatric examination, not elsewhere classified

4.0

8.9

WW500

NOMESCO Finland

Blood transfusion

4.5

8.8

PH2AE

NOMESCO Finland

Ultrasound examination of lower leg veins

2.6

8.8

284

J01FA09

ATC

clarithromycin; systemic

2.0

8.8

129

749

ACC59

NOMESCO Finland

Decompression and freeing of adhesions of peripheral nerve: other or unspecified

14.4

8.7

TAB00

NOMESCO Finland

Lumbar puncture

5.7

8.7

M54.9

ICD-10 Finland

Dorsalgia, unspecified

2.7

8.7

236

L04AX01

ATC

azathioprine; systemic

4.5

8.7

J01MA12

ATC

levofloxacin; systemic

2.2

8.7

102

537

R51.81

ICD-10 Finland

Facial pain NOS

8.5

8.7

S01XA20

ATC

artificial tears and other indifferent preparations; ophthalmic

1.8

8.3

205

1428

N03AF02

ATC

oxcarbazepine; oral

5.3

8.3

M01AB05

ATC

diclofenac; systemic, rectal

1.8

8.3

273

2089

WZB00

NOMESCO Finland

Telephone receipt or other advice

2.1

8.2

110

610

A12AX

ATC

Calcium, combinations with vitamin D and/or other drugs

1.8

8.1

176

1170

J45.9

ICD-10 Finland

Asthma, unspecified

2.2

8.1

455

TAC00

NOMESCO Finland

Peripheral nerve block

34.0

8.1

B00.9

ICD-10 Finland

Herpesviral infection, unspecified

34.0

8.1

S18

ICPC

Laceration/cut

1.8

8.1

186

1263

M54.3

ICD-10 Finland

Sciatica

3.7

8.1

M79.1

ICD-10 Finland

Myalgia

2.6

8.1

251

XCW99

NOMESCO Finland

Other investigative procedure of eye

2.5

8.0

305

R29.8

ICD-10 Finland

Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems

3.1

8.0

148

N06CA01

ATC

amitriptyline and psycholeptics; systemic

2.6

8.0

241

M48.0

ICD-10 Finland

Spinal stenosis

2.5

8.0

295

AA1DG

NOMESCO Finland

Very extensive MRI examination of brain with high intensity magnet

5.3

8.0

M54.4

ICD-10 Finland

Lumbago with sciatica

2.5

7.9

289

H60.9

ICD-10 Finland

Otitis externa, unspecified

3.6

7.8

100

J01CR02

ATC

amoxicillin and beta-lactamase inhibitor; systemic

1.8

7.7

199

1393

M04AA01

ATC

allopurinol; systemic

2.2

7.7

385

XQ800

NOMESCO Finland

Prick test

3.7

7.7

R52.0

ICD-10 Finland

Acute pain

5.3

7.7

XG410

NOMESCO Finland

Flow-volume spirometry

4.3

7.6

L03AA02

ATC

filgrastim; parenteral

5.6

7.6

XW000

NOMESCO Finland

Bone marrow biopsy

3.5

7.5

103

A07AA02

ATC

nystatin; oral

3.1

7.5

146

A46

ICD-10 Finland

Erysipelas

2.2

7.4

388

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

2.5

7.4

255

F32.10

ICD-10 Finland

Moderate depressive episode without somatic syndrome

3.6

7.4

R05

ICPC

Cough

2.0

7.4

104

590

GD1ED

NOMESCO Finland

Extensive high resolution CT examination of lungs

4.4

7.3

L05

ICPC

Flank/axilla symptom/complaint

3.3

7.3

111

G530, B0229

ICD-10 Finland

+∞

7.3

R02

ICPC

Shortness of breath/dyspnoea

2.4

7.3

295

W01

ICD-10 Finland

Fall on same level from slipping, tripping and stumbling

1.8

7.2

158

1043

B01AB05

ATC

enoxaparin; parenteral

1.8

7.2

147

949

B00.10

ICD-10 Finland

Herpes simplex facialis

30.6

7.2

L30.9

ICD-10 Finland

Dermatitis, unspecified

2.2

7.1

369

UJF32

NOMESCO Finland

Coloscopy

1.9

7.1

123

753

A06AC01

ATC

ispaghula (psylla seeds); oral

1.9

7.0

121

739

SPAT1263

SPAT

Sampling

1.7

7.0

187

1313

R52.9

ICD-10 Finland

Pain, unspecified

2.7

7.0

175

M01AE02

ATC

naproxen; oral, rectal

1.7

7.0

223

1652

127

Kela drug reimbursment

Transplant complication

8.5

6.9

N03AE01

ATC

clonazepam; systemic

3.4

6.9

100

H02AB04

ATC

methylprednisolone; systemic

2.1

6.8

421

B02.2

ICD-10 Finland

Zoster with other nervous system involvement

40.7

6.8

B00.19

ICD-10 Finland

Other vesicular dermatitis caused by the herper simplex virus

17.0

6.8

D07AC01

ATC

betamethasone; topical

1.8

6.7

150

991

GD1DD

NOMESCO Finland

High resolution CT examination of lungs

3.5

6.7

N06AA10

ATC

nortriptyline; systemic

5.3

6.7

H19.2

ICD-10 Finland

Keratitis and keratoconjunctivitis in other infectious and parasitic diseases classified elsewhere

22.9

6.7

H02AB09

ATC

hydrocortisone; systemic

6.6

6.7

S19

ICPC

Skin injury other

4.0

6.7

SPAT1254

SPAT

Administration of medicine

2.1

6.7

445

FB1BD

NOMESCO Finland

Extensive CT examination of arteria pulmonalis

2.7

6.6

168

M01AE01

ATC

ibuprofen; systemic, rectal

1.9

6.6

358

3080

J01MA02

ATC

ciprofloxacin; systemic

1.7

6.5

183

1294

M01AC01

ATC

piroxicam; systemic, rectal

2.2

6.5

326

TDM10

NOMESCO Finland

Puncture of maxillary antrum

3.9

6.5

WX408

NOMESCO Finland

General anesthesy, balanced

1.9

6.5

112

681

K57.3

ICD-10 Finland

Diverticular disease of large intestine without perforation or abscess

1.9

6.4

538

DM1AD

NOMESCO Finland

CT of paranasal sinuses and face area

4.5

6.4

A03FA01

ATC

metoclopramide; systemic, rectal

1.9

6.4

562

CJE20

NOMESCO Finland

Phakoemulsification with implantation of artificial lens in posterior chamber

1.7

6.4

188

1345

M01AE03

ATC

ketoprofen; systemic, rectal

1.7

6.4

167

1159

N05BB01

ATC

hydroxyzine; systemic

3.0

6.4

128

H01

ICPC

Ear pain/earache

2.6

6.3

197

K08.80

ICD-10 Finland

Toothache NOS

3.2

6.3

101

M70.6

ICD-10 Finland

Trochanteric bursitis

2.2

6.3

299

R06AE09

ATC

levocetirizine; oral

2.3

6.3

260

JN3BD

NOMESCO Finland

Extensive abdominal CT

2.4

6.3

239

G56.2

ICD-10 Finland

Lesion of ulnar nerve

18.3

6.3

H62.1*B02.8

ICD-10 Finland

Otitis externa in zoster

+∞

6.3

L01BB05

ATC

fludarabine; systemic

+∞

6.3

B02.29

ICD-10 Finland

Herpes zoster polyneuropathy

+∞

6.3

WX109

NOMESCO Finland

Extensive surface anesthesy of skin with external ointment or geel

+∞

6.3

S29

ICPC

Skin symptom/complaint other

2.0

6.3

450

C08CA01

ATC

amlodipine; oral

1.7

6.2

178

1261

R03AK06

ATC

salmeterol and fluticasone; inhalant

2.1

6.2

374

R42

ICD-10 Finland

Dizziness and giddiness

1.8

6.2

116

724

M01AC06

ATC

meloxicam; systemic, rectal

1.7

6.2

156

1066

FM1AE

NOMESCO Finland

Standard cardiac ultrasound examination

1.9

6.1

537

JN1AE

NOMESCO Finland

Ultrasound examination of upper part of abdomen

2.5

6.1

203

F32.9

ICD-10 Finland

Depressive episode, unspecified

2.5

6.1

184

J01FF01

ATC

clindamycin; systemic

1.8

6.1

118

744

SPAT1229

SPAT

Assessment of need for aid

2.4

6.1

229

J01CA04

ATC

amoxicillin; systemic

1.7

6.0

320

2684

C01DA08

ATC

isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal

1.8

6.0

126

813

Mortality – FinRegistry

↥

Association

Association between endpoint G6_POSTZOST and mortality.

Females

Parameter	HR [95% CI]	p-value
G6_POSTZOST	1.259 [1.07, 1.48]	0.005
Birth year	0.995 [0.99, 1.0]	0.291

During the follow-up period (1.1.1998 — 31.12.2019), 668 out of 1848 females with G6_POSTZOST died.

Males

Parameter	HR [95% CI]	p-value
G6_POSTZOST	1.483 [1.21, 1.82]	< 0.001
Birth year	0.99 [0.98, 1.0]	0.031

During the follow-up period (1.1.1998 — 31.12.2019), 466 out of 1086 males with G6_POSTZOST died.

Mortality risk

Mortality risk for people of age

years, who have G6_POSTZOST.

N-year risk	Females	Males
1	0.109%	0.277%
5	0.642%	1.793%
10	1.732%	4.78%
15	3.376%	8.816%
20	6.006%	14.731%

Relationships between endpoints

↥

Index endpoint: G6_POSTZOST – Postzoster neuralgia

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

NAME	G6_POSTZOST
CONTROL_EXCLUDE	G6_NERPLEX
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	G530
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	G530
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Postzoster neuralgia

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints