No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
690 |
4. Check minimum number of eventsNone |
690 |
5. Include endpointsNone |
690 |
6. Filter based on genotype QC (FinnGen only) |
660 |
Control definitions (FinnGen only)
- Control exclude
- H7_OPTNERVE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
Similar endpoints
↥List of similar endpoints to
Optic atrophy
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5582 | 2664 | 2879 |
| Only index persons | 4719 | 2320 | 2399 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.08 | 0.08 |
| Only index persons | 0.09 | 0.09 | 0.09 |
| Median age at first event (years) | |||
| Whole population | 46.61 | 48.27 | 44.98 |
| Only index persons | 45.82 | 47.26 | 44.44 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 660 | 361 | 299 |
| Unadjusted period prevalence (%) | 0.13 | 0.13 | 0.14 |
| Median age at first event (years) | 53.90 | 52.67 | 55.38 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 690
- Matched controls
- 6900
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.2
ICD-10 Finland
Optic atrophy
+∞
307.7
656
*
XCK00
NOMESCO Finland
Perimetry
21.9
296.7
254
179
H53.4
ICD-10 Finland
Visual field defects
28.1
180.4
127
55
CS494
NOMESCO Finland
Other visual field testing
21.5
142.2
111
61
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
19.4
137.7
113
69
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.1
136.7
201
299
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
41.5
116.2
71
19
G35
ICD-10 Finland
Multiple sclerosis
40.9
114.1
70
19
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
48.6
105.5
62
14
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
33.6
103.3
67
22
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
12.4
93.4
98
91
109
Kela drug reimbursment
Multiple sclerosis
55.0
89.2
51
10
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
8.1
87.1
131
195
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
27.3
86.5
60
24
H46
ICD-10 Finland
Optic neuritis
+∞
83.0
78
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.0
79.3
168
354
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.6
77.0
253
769
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.8
76.7
165
352
XCD10
NOMESCO Finland
Electrophysiological examination of eye
13.7
75.5
73
59
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
7.0
64.7
108
178
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
64.6
61
*
XCK10
NOMESCO Finland
Photography of fundus of eye
5.1
58.6
142
332
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
22.9
58.2
43
20
101
Kela drug reimbursment
Anterior pituitary hypofunction
21.3
57.8
44
22
Z3229
NOMESCO Finland
Other healthcare associate professional
4.9
53.3
135
326
H47.1
ICD-10 Finland
Papilloedema, unspecified
559.0
53.2
52
*
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.8
52.9
139
346
TAB00
NOMESCO Finland
Lumbar puncture
6.6
51.2
89
152
N03AX14
ATC
levetiracetam; systemic
9.3
51.1
64
75
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
10.1
48.7
57
61
H02AB09
ATC
hydrocortisone; systemic
9.2
48.4
61
72
AA1AD
NOMESCO Finland
CT of head and brain
3.3
47.8
271
1137
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
18.0
43.9
36
21
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
17.5
42.1
35
21
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
9.5
40.3
49
55
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
10.9
39.9
44
43
N86
ICPC
Multiple sclerosis
91.6
39.3
43
5
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
60.0
38.8
45
8
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
9.0
38.7
49
58
E23.00
ICD-10 Finland
Panhypopituitarism
87.1
37.2
41
5
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
4.1
32.8
98
265
37790
ICD-8 Finland
Other diseases of retina and optic nerve, Atrophia (et degeneratio) nervi optici (tabica excepta)
+∞
31.5
30
*
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
30.4
29
*
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
7.9
30.0
42
56
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
7.8
29.6
42
57
G40.9
ICD-10 Finland
Epilepsy, unspecified
5.7
29.5
57
107
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
30.8
28.8
38
13
XA800
NOMESCO Finland
Neuropsychological investigation
4.7
27.6
68
158
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
39.6
27.3
34
9
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
29.1
26.9
36
13
R56.8
ICD-10 Finland
Other and unspecified convulsions
4.3
26.6
72
180
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
36.0
24.5
31
9
N03AF02
ATC
oxcarbazepine; oral
5.0
22.8
51
109
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.9
22.6
121
470
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
22.3
22.3
32
15
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
30.2
22.0
29
10
SPAT1229
SPAT
Assessment of need for aid
3.6
22.0
78
236
N03AG01
ATC
valproic acid; systemic, rectal
3.7
21.9
73
212
G91.0
ICD-10 Finland
Communicating hydrocephalus
29.1
21.1
28
10
102
Kela drug reimbursment
Diabetes insipidus
216.3
20.7
21
*
M03BX01
ATC
baclofen; systemic
6.9
20.6
32
48
G91.1
ICD-10 Finland
Obstructive hydrocephalus
28.0
20.2
27
10
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
6.2
19.7
34
57
H54.7
ICD-10 Finland
Unspecified visual loss
25.5
19.7
27
11
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
47.5
19.3
23
5
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
47.5
19.3
23
5
3771A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic atrophy
+∞
18.8
18
*
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
+∞
18.8
18
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
18.8
18
*
L03AB07
ATC
interferon beta-1a; parenteral
54.0
18.0
21
*
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.4
18.0
141
657
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
7.5
17.9
26
36
WX882
NOMESCO Finland
High dependency care
4.2
17.7
49
124
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.5
17.7
133
609
N04BB01
ATC
amantadine; oral
13.6
17.6
30
23
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
17.5
142
673
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
6.6
17.2
28
44
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
51.4
17.1
20
*
H53.2
ICD-10 Finland
Diplopia
4.7
16.5
39
87
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
48.7
16.1
19
*
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.8
16.0
88
344
N05BA09
ATC
clobazam; oral
15.0
15.9
26
18
A06AD11
ATC
lactulose; oral
2.4
15.6
121
559
H54.0
ICD-10 Finland
Blindness, binocular
163.6
15.5
16
*
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
39.0
15.4
19
5
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
16.5
15.3
24
15
ZXE13
NOMESCO Finland
Procedure duration 90 to 119 minutes
3.6
15.3
51
148
L03AX13
ATC
glatiramer acetate; parenteral
46.1
15.1
18
*
N03AF01
ATC
carbamazepine; oral, rectal
3.4
14.4
53
164
H54.4
ICD-10 Finland
Blindness, monocular
27.8
14.3
19
7
183
Kela drug reimbursment
Lamotrigin and topiramate
10.8
14.3
27
26
Z2445
NOMESCO Finland
Psychologist
3.4
14.3
53
165
N03AX18
ATC
lacosamide; systemic
14.8
14.1
23
16
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
3.8
14.1
44
122
R35
ICD-10 Finland
Polyuria
3.0
13.6
62
218
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.4
13.5
51
160
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
142.7
13.5
14
*
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
2.7
13.5
75
295
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
26.3
13.4
18
7
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.8
13.4
294
1980
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
21.7
13.4
19
9
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
21.7
13.4
19
9
SPAT1292
SPAT
Other function in accordance with SHToL (Finnish classification of nursing interventions)
2.7
12.9
75
301
N05CD08
ATC
midazolam; nasal, systemic
4.4
12.8
32
75
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
12.7
111
539
9530/0-C70.9
ICD-O-3
Meningioma, NOS, of meninges, NOS
71.2
12.6
14
*
H53.1
ICD-10 Finland
Subjective visual disturbances
3.0
12.6
59
211
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
5.2
12.5
26
52
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
5.2
12.5
26
52
N03AE01
ATC
clonazepam; systemic
3.2
12.4
50
164
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
4.9
12.2
27
57
L28
ICPC
Limited function/disability (L)
2.1
12.2
130
682
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.9
12.1
57
205
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
21.7
12.1
17
8
-, ,
ICD-10 Finland
4.8
12.0
27
58
N03AX09
ATC
lamotrigine; oral
3.2
11.9
47
152
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.2
11.7
113
570
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
13.9
11.5
19
14
34099
ICD-8 Finland
Multiple sclerosis
122.0
11.5
12
*
L04AA27
ATC
[U] fingolimod
122.0
11.5
12
*
SPAT1216
SPAT
Assessment of functional ability
2.1
11.5
117
603
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.1
11.4
126
669
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
9.1
11.3
23
26
N03AB02
ATC
phenytoin; systemic
5.7
11.2
21
38
ZXA10
NOMESCO Finland
Bilateral
2.0
11.2
141
786
H01AC01
ATC
somatropin; parenteral
8.8
11.1
23
27
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.5
11.1
27
62
H53.9
ICD-10 Finland
Visual disturbance, unspecified
3.6
11.0
37
108
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
44.1
10.9
13
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
44.1
10.9
13
*
L03AB08
ATC
interferon beta-1b; parenteral
44.1
10.9
13
*
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
15.8
10.9
17
11
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
28.5
10.8
14
5
N03AX11
ATC
topiramate; oral
4.2
10.7
28
68
164
Kela drug reimbursment
Fingolimod
61.0
10.7
12
*
D35.30
ICD-10 Finland
Craniopharyngoma
61.0
10.7
12
*
Z2446
NOMESCO Finland
Social worker
2.5
10.6
68
286
N03AX16
ATC
[U] pregabalin
1.9
10.6
164
977
ZXC95
NOMESCO Finland
Use of surgical navigator
8.7
10.6
22
26
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
10.5
310
2231
E23.05
ICD-10 Finland
Lack of TSH
111.7
10.4
11
*
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
+∞
10.4
10
*
H47.7
ICD-10 Finland
Disorder of visual pathways, unspecified
+∞
10.4
10
*
114
Kela drug reimbursment
Glaucoma
2.5
10.4
68
289
N05BA01
ATC
diazepam; systemic, rectal
2.1
10.4
103
524
ZXD05
NOMESCO Finland
Urgent procedure
1.8
10.4
214
1393
G04BD07
ATC
tolterodine; oral
3.1
10.3
44
149
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
9.0
10.3
21
24
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
4.8
10.3
23
49
H34.1
ICD-10 Finland
Central retinal artery occlusion
19.1
10.3
15
8
Z3231
NOMESCO Finland
Registered nurse
1.8
10.2
206
1330
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.5
10.2
68
292
XKD00
NOMESCO Finland
Uroflowmetry
2.1
10.1
105
543
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
11.5
10.1
18
16
XKC03
NOMESCO Finland
Water cystometry
3.8
10.1
31
85
H26.4
ICD-10 Finland
After-cataract
2.4
10.1
72
319
EBA15
NOMESCO Finland
Extraction of multiple teeth
3.4
10.0
36
110
H40.11
ICD-10 Finland
Low pressure glaucoma
5.0
9.8
21
43
SPAT1234
SPAT
Support of social functional capacity
3.0
9.7
42
144
R32
ICD-10 Finland
Unspecified urinary incontinence
4.1
9.6
26
65
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.7
9.6
51
196
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.7
9.5
52
203
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
3.6
9.4
31
89
2132
FHL
Ventricular operators sunt
101.4
9.4
10
*
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
+∞
9.4
9
*
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
9.4
9
*
P85
ICPC
Mental retardation
12.6
9.4
16
13
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
22.0
9.4
13
6
OAB43, ,
SPAT
0.4
9.3
55
1188
A28
ICPC
Limited function/disability NOS
2.0
9.2
119
665
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
37.2
9.0
11
*
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
37.2
9.0
11
*
AA1AA
NOMESCO Finland
Head X-ray examination
7.6
9.0
20
27
ZXC86
NOMESCO Finland
Use of endoscopic device
18.9
9.0
13
7
G81.9
ICD-10 Finland
Hemiplegia, unspecified
8.1
8.9
19
24
R4120
NOMESCO Finland
Occupational therapy
2.5
8.9
59
253
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.9
218
1479
G04BD09
ATC
trospium; oral
4.2
8.8
23
56
H54.5
ICD-10 Finland
Severe visual impairment, monocular
14.3
8.7
14
10
G81.1
ICD-10 Finland
Spastic hemiplegia
50.6
8.7
10
*
353
Kela drug reimbursment
Cladribine and fingolimod
50.6
8.7
10
*
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
50.6
8.7
10
*
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
10.2
8.6
16
16
G91.8
ICD-10 Finland
Other hydrocephalus
27.9
8.5
11
*
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
20.3
8.5
12
6
E23.2
ICD-10 Finland
Diabetes insipidus
91.1
8.4
9
*
E22.80
ICD-10 Finland
Central precocious puberty
91.1
8.4
9
*
L04AA31
ATC
[U] teriflunomide
91.1
8.4
9
*
SPAT1254
SPAT
Administration of medicine
1.9
8.4
106
588
L04AX01
ATC
azathioprine; systemic
3.0
8.4
36
123
SPAT1215
SPAT
Assessment of need for medical rehabilitation
3.0
8.4
36
123
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
9.6
8.3
16
17
R51.80
ICD-10 Finland
Headache
1.9
8.2
115
660
S01EE04
ATC
travoprost; ophthalmic
4.6
8.2
19
42
H03AA01
ATC
levothyroxine sodium; systemic
1.8
8.1
157
993
AAD10
NOMESCO Finland
Evacuation of chronic subdural haematoma
8.3
8.1
17
21
F83
ICD-10 Finland
Mixed specific developmental disorders
6.9
8.1
19
28
G93.0
ICD-10 Finland
Cerebral cysts
33.8
8.1
10
*
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
33.8
8.1
10
*
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
33.8
8.1
10
*
H50.1
ICD-10 Finland
Divergent concomitant strabismus
10.2
8.1
15
15
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
10.2
8.1
15
15
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
2.3
8.0
64
298
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
6.7
7.9
19
29
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
7.9
91
488
301
Kela drug reimbursment
Growth hormone
13.2
7.9
13
10
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
13.2
7.9
13
10
F32.9
ICD-10 Finland
Depressive episode, unspecified
2.0
7.9
90
481
A02BC03
ATC
lansoprazole; oral
1.7
7.8
189
1269
PAW37
NOMESCO Finland
Biopsy of temporal artery
11.0
7.8
14
13
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.0
7.7
20
34
ZXA00
NOMESCO Finland
Right side
1.7
7.7
180
1199
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.9
7.7
107
613
H52.0
ICD-10 Finland
Hypermetropia
3.7
7.6
24
67
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.7
7.6
188
1269
H53.0
ICD-10 Finland
Amblyopia ex anopsia
6.3
7.6
19
31
L04AA06
ATC
mycophenolic acid; systemic
4.2
7.6
20
49
H52.1
ICD-10 Finland
Myopia
3.0
7.5
33
114
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
4.3
7.5
19
45
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
1.8
7.5
114
671
ZXE20
NOMESCO Finland
More than three and less than five hours
1.9
7.4
101
573
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
80.9
7.4
8
*
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
80.9
7.4
8
*
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
6.1
7.4
19
32
H04.10
ICD-10 Finland
Dry eye syndrome
2.1
7.4
77
398
UKC02
NOMESCO Finland
Cystoscopy
1.9
7.4
103
589
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
2.0
7.4
87
470
H25.8
ICD-10 Finland
Other senile cataract
2.1
7.4
71
356
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
6.9
7.3
17
25
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
11.0
7.3
13
12
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
9.5
7.3
14
15
G80.0
ICD-10 Finland
Spastic quadriplegic cerebral palsy
+∞
7.3
7
*
37799
ICD-8 Finland
Other diseases of retina and optic nerve, Unspecified
+∞
7.3
7
*
74200
ICD-8 Finland
Congenital hydrocephalus, Communicans
+∞
7.3
7
*
C72.3
ICD-10 Finland
Malignant neoplasm: Optic nerve
+∞
7.3
7
*
ZXE10
NOMESCO Finland
More than one and less than three hours
1.6
7.3
237
1709
N30.0
ICD-10 Finland
Acute cystitis
1.9
7.3
103
592
R3120
NOMESCO Finland
Training in mobility skills
15.9
7.2
11
7
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
15.9
7.2
11
7
RD210, ,
NOMESCO Finland
3.8
7.2
22
60
RS222, ,
NOMESCO Finland
7.4
7.2
16
22
H50.31
ICD-10 Finland
Intermittent exotropia
4.6
7.2
17
38
ZXD10
NOMESCO Finland
Scheduled procedure
1.6
7.2
256
1885
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
30.3
7.2
9
*
RS140, ,
NOMESCO Finland
20.3
7.1
10
5
N18
ICPC
Paralysis/weakness
4.1
7.1
19
47
SPAT1231
SPAT
Assessment of adjustments needed in living environment
4.1
7.1
19
47
G40.10
ICD-10 Finland
Simple partial seizures
8.9
7.1
14
16
S06.5
ICD-10 Finland
Traumatic subdural haemorrhage
3.3
7.0
26
81
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.0
7.0
76
400
S01ED01
ATC
timolol; ophthalmic
3.2
6.9
27
87
XKD06
NOMESCO Finland
Physiologic investigation of micturition
3.2
6.9
27
87
Z02.7
ICD-10 Finland
Issue of medical certificate
2.3
6.9
52
236
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.3
6.9
52
236
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.6
6.9
183
1256
SPAT1172
SPAT
Guidance concerning hydration
4.2
6.8
18
44
R62.0
ICD-10 Finland
Delayed milestone
5.7
6.8
18
32
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
6.8
194
1353
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.0
6.8
29
99
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
40.5
6.8
8
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
6.7
96
553
L04AX07
ATC
dimethyl fumarate; oral
22.8
6.7
9
*
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
5.6
6.6
18
33
SPAT1255
SPAT
Intravenous administration of medicine
2.4
6.6
45
195
CS2P4
NOMESCO Finland
Optic nerve head imaging
7.9
6.6
14
18
ZXE30
NOMESCO Finland
More than five and less than seven hours
2.6
6.6
39
158
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
3.5
6.6
22
64
D32.01
ICD-10 Finland
Benign tumor of meninges on interhemispheric surface
12.4
6.6
11
9
G40.89
ICD-10 Finland
Other epilepsy
12.4
6.6
11
9
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
12.4
6.6
11
9
SPAT1249
SPAT
Treatment-related counselling outside office
1.5
6.6
247
1832
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
6.9
6.5
15
22
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.5
6.5
22
65
R42
ICD-10 Finland
Dizziness and giddiness
1.7
6.4
143
935
9380/3-C71.9
ICD-O-3
Glioma, malignant of brain, NOS
70.5
6.4
7
*
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
70.5
6.4
7
*
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
70.5
6.4
7
*
XCH05
NOMESCO Finland
Eye pressure longterm registration
7.5
6.4
14
19
S01ED51
ATC
timolol, combinations; ophthalmic
2.2
6.4
54
257
PA2LT
NOMESCO Finland
Endovascular closure of extensive brain aneurysm
14.5
6.4
10
7
504
Kela drug reimbursment
Conditions requiring daily forced enteral nutrition
4.1
6.4
17
42
N29
ICPC
Neurological sympt/complt other
4.1
6.4
17
42
7423A
ICD-9 Finland
Other congenital anomalies of nervous system, Congenital hydrocephalus
+∞
6.3
6
*
2377A
ICD-9 Finland
Neoplasm of uncertain behaviour of endocrine glands and nervous system, Neurofibromatosis
+∞
6.3
6
*
AAK00
NOMESCO Finland
Cranioplasty
+∞
6.3
6
*
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
+∞
6.3
6
*
E23.0
ICD-10 Finland
Hypopituitarism
+∞
6.3
6
*
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.9
6.3
87
497
N07XX09
ATC
[U] dimethyl fumarate
26.9
6.2
8
*
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
26.9
6.2
8
*
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
2.2
6.2
52
247
WZC00
NOMESCO Finland
Treatment plan or consultation
1.5
6.2
228
1679
JDB10
NOMESCO Finland
Percutaneous gastrostomy
5.8
6.2
16
28
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
8.7
6.1
12
14
S00.0
ICD-10 Finland
Superficial injury of scalp
3.4
6.0
21
63
G40
ICD-10 Finland
Epilepsy
5.6
6.0
16
29
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.9
6.0
17
44
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
69
130
5.79
35.66
1.6
1.9
617.63
423.12
mg/l
0.75
64
121
62
117
5.72
31.93
1.4
1.8
3.70
3.65
mmol/l
0.09
57
109
61
117
5.62
30.86
1.9
1.9
1328.33
1065.42
e6/l
0.08
48
97
61
117
5.62
30.86
1.9
1.9
23.17
12.19
e6/l
0.26
48
95
32
29
11.52
30.42
2.2
1.4
—
—
—
0
0
38
50
7.98
27.43
2.0
1.4
—
—
—
0
0
29
37
8.14
21.42
1.0
1.0
—
—
—
0
0
31
49
6.58
18.97
1.0
1.1
—
—
—
0
0
126
560
2.53
17.83
3.8
2.0
372.38
362.19
nmol/l
0.06
117
517
32
56
5.94
17.73
1.1
1.1
—
—
—
0
0
26
38
7.07
17.08
1.1
1.1
246.19
197.19
mg/l
0.91
21
32
36
74
5.08
16.79
1.2
1.1
—
—
—
0
0
137
651
2.38
16.69
11.5
7.0
—
—
—
0
0
25
39
6.61
15.47
2.4
1.7
—
—
—
0
0
29
54
5.56
15.06
1.1
1.1
—
—
—
0
0
14
0
+∞
14.63
1.4
0.0
—
—
—
0
0
358
2528
1.86
14.29
10.8
7.1
1.21
1.22
mmol/l
0.97
331
2323
382
2768
1.85
13.90
10.4
7.5
1.22
1.22
mmol/l
0.02
337
2391
36
87
4.31
13.83
4.7
5.6
458.45
373.34
umol/l
1.93
29
79
254
1622
1.90
13.79
2.6
2.1
189.21
245.29
u/l
0.55
234
1533
26
26
10.35
13.57
1.1
1.0
1.39
1.09
u/l
—
10
15
23
39
6.07
13.13
5.2
2.9
—
—
—
0
0
154
849
2.05
12.69
2.3
2.3
29.16
29.66
s
0.56
147
823
426
3248
1.81
12.57
7.7
5.4
6.65
6.65
mmol/l
0.01
411
3037
51
173
3.10
11.94
2.8
1.6
6.40
9.38
u/l
0.90
38
140
207
1302
1.84
11.39
2.9
2.3
—
—
—
0
0
318
2297
1.71
10.69
6.5
5.2
35.14
35.74
g/l
0.98
294
2142
151
879
1.92
10.47
2.0
1.9
—
—
—
0
0
372
2816
1.70
10.41
7.9
6.6
10.85
12.91
umol/l
2.24
345
2659
451
3598
1.73
10.37
7.3
4.3
3557.75
2627.02
e6/l
—
8
50
138
791
1.93
9.99
6.9
6.2
1.04
1.08
mmol/l
0.83
130
735
72
322
2.38
9.87
1.6
1.7
—
—
—
0
0
150
920
1.81
8.68
4.9
4.1
0.82
0.82
mmol/l
0.33
144
869
291
2135
1.63
8.68
2.1
1.9
94.87
94.89
pmol/l
0.00
166
1115
500
4195
1.70
8.64
9.5
7.4
84.06
81.73
u/l
0.37
465
3937
274
2023
1.59
7.72
4.7
3.2
—
—
—
0
0
406
3285
1.57
7.64
13.2
9.2
4.44
4.03
e9/l
2.34
368
2853
15
17
8.99
7.57
1.1
1.0
1818.07
1412.06
miu/ml
0.49
15
17
17
24
7.23
7.51
2.9
3.3
28.07
34.71
umol/l
0.76
11
17
107
621
1.86
7.34
10.4
9.7
5.06
5.10
kpa
0.19
102
591
107
621
1.86
7.34
10.4
9.7
14.02
12.51
kpa
1.65
101
593
149
963
1.70
7.06
3.0
2.9
1.03
0.90
e6/l
0.21
85
545
105
618
1.82
6.87
1.8
1.9
—
—
—
0
0
495
4241
1.59
6.87
4.9
3.9
14.89
14.73
pmol/l
0.64
446
3861
83
454
1.94
6.81
2.3
2.4
3.98
7.20
ug/l
2.82
67
399
105
620
1.82
6.80
10.6
9.7
1.06
1.15
mmol/l
0.07
79
492
105
626
1.80
6.58
1.9
1.9
—
—
—
0
0
18
34
5.41
6.50
1.2
1.1
—
—
—
0
0
39
162
2.49
6.31
1.6
1.5
0.09
0.12
iu/ml
—
6
33
80
444
1.91
6.28
7.4
5.3
2.01
1.65
mmol/l
0.45
67
325
145
960
1.65
6.21
1.8
1.7
1224.01
1206.07
nmol/l
0.08
111
738
68
363
1.97
5.99
9.0
5.4
24.09
23.73
mmol/l
0.55
68
358
99
599
1.76
5.89
9.0
5.2
2.14
1.71
mmol/l
0.53
82
482
288
2247
1.48
5.86
2.9
2.4
78.96
76.23
nmol/l
0.74
256
2029
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
17
35
4.95
5.77
1.1
1.1
—
—
—
0
0
45
210
2.22
5.64
2.2
2.0
—
—
—
0
0
171
1212
1.55
5.44
1.6
1.5
19.64
20.30
nmol/l
0.22
147
1036
30
120
2.57
5.27
1.5
1.4
—
—
—
0
0
30
120
2.57
5.27
1.5
1.4
—
—
—
0
0
617
5699
1.78
5.21
25.9
16.2
139.56
139.64
mmol/l
0.28
602
5544
89
542
1.74
5.17
2.5
2.5
0.21
0.21
g/l
0.34
84
512
171
1226
1.52
5.13
8.0
3.9
1.02
1.02
kg/l
0.09
20
185
14
27
5.27
5.10
1.1
1.1
—
—
—
0
0
28
111
2.59
5.02
1.7
1.5
—
—
—
0
0
75
439
1.79
4.99
4.1
2.2
12.30
12.81
nmol/l
0.23
69
390
617
5716
1.75
4.92
25.5
16.2
3.95
3.97
mmol/l
0.96
599
5550
331
2723
1.41
4.78
9.9
6.0
57.35
56.05
%
1.09
319
2570
58
318
1.90
4.75
1.6
1.4
—
—
—
0
0
10
14
7.23
4.66
2.1
2.1
25.01
15.92
umol/l
—
10
14
206
1561
1.46
4.65
3.6
3.2
0.52
0.40
e6/l
0.19
158
1184
332
2757
1.39
4.42
10.6
6.2
27.96
28.81
%
0.66
320
2604
182
1367
1.45
4.25
2.6
2.2
3.34
3.02
mg/l
1.06
153
1172
300
2461
1.39
4.24
15.7
13.8
1.21
1.23
inr
0.12
52
697
558
5096
1.50
4.17
5.2
4.6
1.94
2.13
mu/l
0.39
500
4676
34
161
2.17
4.16
1.5
1.4
—
—
—
0
0
39
198
2.03
4.00
2.1
1.8
—
—
—
0
0
56
322
1.80
3.98
2.4
3.4
4.35
4.63
pmol/l
0.78
50
289
323
2706
1.36
3.92
6.2
3.6
0.00
0.00
estimate
0.50
44
528
601
5604
1.56
3.78
21.7
13.9
27.96
23.10
mg/l
2.01
494
4365
11
24
4.64
3.75
1.2
1.1
—
—
—
0
0
34
631
0.51
3.61
1.5
2.1
—
—
—
0
0
34
172
2.03
3.55
3.0
3.1
148.68
185.10
%
2.51
34
167
33
166
2.04
3.50
3.4
3.1
—
—
—
0
0
96
658
1.53
3.49
4.4
4.3
31.10
31.32
%
0.07
68
445
19
75
2.58
3.49
1.3
1.3
—
—
—
0
0
249
2032
1.35
3.47
4.2
3.6
75.87
40.46
ng/l
0.52
195
1388
302
2540
1.34
3.43
3.1
2.6
—
—
—
0
0
11
27
4.12
3.40
6.2
2.8
43718.18
36322.41
ug/l
0.58
11
27
322
2736
1.33
3.40
6.3
3.6
0.00
0.01
estimate
0.80
43
480
67
425
1.64
3.38
2.4
2.6
72.83
67.34
ml/min/173m2
0.48
29
177
7
10
7.06
3.37
1.1
1.5
—
—
—
0
0
152
1150
1.41
3.35
3.5
2.6
4.95
4.88
e6/l
0.03
141
1040
9
19
4.78
3.24
4.6
2.0
—
—
—
0
0
183
1437
1.37
3.22
7.6
3.9
0.00
0.01
estimate
0.69
40
487
38
208
1.88
3.19
1.6
2.1
1.60
1.49
g/l
0.25
33
183
31
564
0.53
3.10
1.5
2.0
—
—
—
0
0
316
2709
1.31
3.02
7.6
4.9
0.00
0.00
estimate
0.50
41
497
192
1539
1.34
2.94
3.4
3.2
1177.00
1345.00
ng/l
0.34
163
1301
210
1707
1.33
2.92
4.2
3.3
313.86
85.01
e6/l
0.39
161
1319
123
923
1.40
2.82
3.2
3.0
2.41
1.89
e6/l
0.31
58
509
10
28
3.61
2.79
1.1
1.0
—
—
—
0
0
10
28
3.61
2.79
2.6
1.7
201.20
116.70
ng/l
—
10
22
36
203
1.82
2.79
3.8
3.1
94.89
89.30
%
0.85
36
198
222
1835
1.31
2.71
3.4
3.5
2.36
2.36
mmol/l
0.25
184
1624
6
10
6.04
2.70
1.2
1.3
—
—
—
0
0
103
755
1.43
2.70
2.6
2.5
20.87
22.38
%
0.44
90
647
204
1674
1.31
2.62
2.6
2.6
53.63
60.41
u/l
0.78
184
1552
107
797
1.41
2.57
2.5
2.5
2.23
2.37
g/l
1.27
93
738
114
860
1.39
2.54
2.6
2.5
12.01
13.16
umol/l
0.87
100
799
7
16
4.41
2.48
1.1
1.2
—
—
—
0
0
64
436
1.52
2.43
5.2
4.4
86.51
79.75
ng/l
0.22
58
399
217
1811
1.29
2.43
4.9
3.5
41.80
32.69
u/l
0.74
203
1724
6
12
5.03
2.40
1.2
1.2
—
—
—
0
0
30
168
1.82
2.40
1.4
1.4
330.77
298.22
ug/g
0.29
14
102
5
8
6.29
2.37
2.2
3.1
—
—
—
0
0
10
33
3.06
2.36
1.8
1.5
—
—
—
0
0
11
39
2.85
2.35
2.5
2.5
—
—
—
0
0
59
399
1.52
2.33
2.0
1.7
—
—
—
0
0
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
31
178
1.78
2.30
3.4
3.2
0.39
0.36
u/ml
0.24
18
106
32
186
1.76
2.28
1.6
1.6
—
—
—
0
0
8
23
3.51
2.27
2.4
2.5
112.88
95.75
ug/l
—
8
23
10
35
2.88
2.21
1.3
1.1
—
—
—
0
0
447
4098
1.26
2.18
4.6
4.1
12.99
11.66
mm/h
1.05
416
3786
618
5918
1.42
2.15
15.0
10.2
27.64
26.67
u/l
0.36
595
5715
29
481
0.59
2.15
1.4
1.7
—
—
—
0
0
124
975
1.33
2.13
3.4
2.9
2.47
2.45
mmol/l
1.26
104
850
18
89
2.05
2.07
1.3
1.2
2.83
4.26
u/ml
—
6
38
5
10
5.03
2.07
3.6
1.4
—
—
—
0
0
7
20
3.52
2.06
1.1
1.3
—
—
—
0
0
6
15
4.03
2.04
1.0
1.1
—
—
—
0
0
6
15
4.03
2.04
1.0
1.1
—
—
—
0
0
14
63
2.25
2.02
1.5
1.9
—
—
—
0
0
71
515
1.42
2.00
3.8
2.4
32.36
134.27
u/l
0.56
61
434
13
57
2.31
1.98
2.5
3.0
3.70
6.59
nmol/l
0.47
13
57
22
120
1.86
1.94
9.3
9.1
1208.22
212.17
iu/ml
—
9
24
5
11
4.57
1.94
2.0
1.7
—
—
—
0
0
6
16
3.77
1.94
1.2
1.1
—
—
—
0
0
17
85
2.03
1.91
1.3
1.2
5.83
4.32
u/ml
—
6
25
10
217
0.45
1.76
1.4
1.5
—
—
—
0
0
12
54
2.24
1.74
3.1
2.4
—
—
—
0
0
16
83
1.95
1.65
1.1
1.1
—
—
—
0
0
25
151
1.68
1.62
2.2
1.9
—
—
—
0
0
19
106
1.81
1.60
2.1
2.0
—
—
—
0
0
14
70
2.02
1.60
1.1
2.3
—
1680.00
—
0
5
12
57
2.12
1.55
2.0
1.2
—
—
—
0
0
37
250
1.51
1.53
3.0
1.5
18.26
26.20
iu/l
0.81
32
210
83
648
1.32
1.52
6.0
3.1
6.59
7.95
umol/l
0.64
74
564
25
154
1.65
1.52
1.8
1.9
—
—
—
0
0
15
80
1.89
1.45
1.3
1.6
—
—
—
0
0
144
1213
1.24
1.45
2.0
1.9
1.34
1.24
mg/l
0.18
104
922
5
16
3.14
1.44
1.2
1.1
—
—
—
0
0
20
118
1.72
1.42
1.9
1.9
—
—
—
0
0
20
118
1.72
1.42
1.9
1.9
—
—
—
0
0
10
46
2.19
1.40
7.5
2.6
55.60
38.10
%
—
10
25
25
158
1.60
1.39
1.2
1.2
—
24.95
—
0
6
9
41
2.21
1.37
1.1
1.3
—
—
—
0
0
9
42
2.16
1.34
1.1
1.3
—
—
—
0
0
9
43
2.11
1.30
1.0
1.2
—
—
—
0
0
235
2100
1.18
1.26
6.9
3.7
—
—
—
0
0
11
203
0.53
1.26
3.2
1.9
—
—
—
0
0
6
25
2.41
1.24
4.2
2.8
373.17
702.76
u/ml
—
6
25
22
139
1.60
1.24
1.3
1.7
—
—
—
0
0
18
108
1.68
1.23
1.1
1.0
—
18.92
—
0
5
90
1091
0.80
1.20
1.5
1.6
—
—
—
0
0
6
26
2.32
1.19
3.0
2.2
—
—
—
0
0
6
26
2.32
1.19
3.0
2.2
—
—
—
0
0
8
38
2.12
1.18
1.8
1.3
—
—
—
0
0
6
130
0.46
1.16
1.3
1.6
—
—
—
0
0
0
36
0.00
1.14
0.0
7.5
—
37.67
—
0
12
390
3649
1.16
1.13
5.1
3.2
60.62
47.93
u/l
1.56
363
3422
19
119
1.61
1.12
1.0
1.2
—
2.24
—
0
9
18
112
1.62
1.09
2.2
2.1
133.67
132.11
g/l
—
9
84
14
81
1.74
1.09
1.1
1.7
—
—
—
0
0
529
5076
1.18
1.07
17.7
12.6
84.25
82.26
ml/min/173m2
1.08
446
4169
6
121
0.49
1.06
1.3
1.5
—
—
—
0
0
6
121
0.49
1.06
1.3
1.5
—
—
—
0
0
6
121
0.49
1.06
1.3
1.4
—
—
—
0
0
6
121
0.49
1.06
1.3
1.4
—
—
—
0
0
25
170
1.49
1.06
1.4
1.2
—
—
—
0
0
25
170
1.49
1.06
1.8
1.2
—
—
—
0
0
7
33
2.13
1.05
2.1
4.0
99.86
89.39
%
—
7
33
23
154
1.51
1.05
1.7
1.6
—
—
—
0
0
262
2392
1.15
1.04
3.1
2.8
138.38
121.77
ug/l
0.53
233
2219
9
46
1.97
1.04
1.0
1.2
—
70.43
—
0
7
180
1598
1.17
1.04
3.8
3.8
9.25
10.01
mg/mmol
0.11
111
1015
5
22
2.28
1.03
1.0
1.2
14.10
8.85
ug/l
—
5
22
11
60
1.85
1.03
2.7
3.9
—
—
—
0
0
14
83
1.70
1.02
2.6
1.9
—
—
—
0
0
25
172
1.47
1.01
1.4
1.2
—
—
—
0
0
37
275
1.37
0.99
7.6
4.4
25.30
24.96
mmol/l
0.17
37
268
187
1672
1.16
0.98
4.5
4.7
1.80
2.41
ug/l
1.30
164
1503
5
23
2.18
0.98
3.6
2.5
—
—
—
0
0
16
100
1.61
0.97
2.3
2.4
16.89
16.51
%
—
7
49
14
85
1.66
0.95
1.4
1.9
—
—
—
0
0
14
85
1.66
0.95
1.4
1.9
—
—
—
0
0
6
27
2.23
0.93
3.2
2.1
—
—
—
0
0
187
1682
1.15
0.91
3.3
3.4
7.23
7.70
mmol/l
0.83
160
1432
11
63
1.76
0.90
1.5
1.3
0.45
0.57
nmol/l
0.89
11
58
6
29
2.08
0.89
1.0
1.8
—
—
—
0
0
20
137
1.47
0.85
2.4
1.8
2.68
5.51
iu/l
—
5
43
14
88
1.60
0.85
1.5
1.7
—
—
—
0
0
12
73
1.66
0.82
2.4
2.0
—
—
—
0
0
11
66
1.68
0.79
1.6
1.7
91.08
90.22
%
0.16
11
66
18
123
1.48
0.78
2.7
1.7
—
—
—
0
0
545
5286
1.15
0.76
4.9
4.4
5.81
5.95
mmol/l
1.84
491
4846
24
175
1.38
0.75
2.5
2.3
12417.45
3975.53
u/l
—
6
69
5
24
2.09
0.74
1.0
1.8
—
—
—
0
0
16
108
1.49
0.74
1.4
1.7
—
—
—
0
0
5
25
2.01
0.73
1.0
1.8
—
—
—
0
0
5
25
2.01
0.73
1.0
1.2
166.80
114.42
iu/ml
—
5
25
14
92
1.53
0.72
1.1
1.7
—
—
—
0
0
44
354
1.26
0.72
7.8
4.7
130.86
127.17
g/l
0.60
44
349
24
320
0.74
0.71
2.3
1.9
—
—
—
0
0
636
6252
1.22
0.70
32.5
20.6
39.81
40.24
%
1.04
600
5876
7
41
1.71
0.70
1.0
1.1
—
—
—
0
0
7
41
1.71
0.70
1.0
1.1
—
—
—
0
0
636
6253
1.22
0.69
32.0
20.3
257.07
251.50
e9/l
1.12
619
6086
5
27
1.86
0.68
1.4
1.1
57.00
100.63
u/l
—
5
27
5
27
1.86
0.68
1.4
1.1
9.40
35.84
u/l
—
5
27
7
42
1.67
0.68
1.0
1.1
—
—
—
0
0
7
42
1.67
0.68
1.0
1.1
—
—
—
0
0
7
42
1.67
0.68
1.0
1.1
—
—
—
0
0
5
91
0.55
0.67
1.4
1.6
—
—
—
0
0
636
6256
1.21
0.67
32.0
20.3
4.46
4.51
e12/l
2.08
618
6074
5
28
1.79
0.66
1.6
1.3
—
—
—
0
0
5
28
1.79
0.66
1.6
1.3
—
—
—
0
0
636
6259
1.21
0.64
32.2
20.4
133.35
135.58
g/l
3.31
625
6168
17
121
1.42
0.62
1.1
1.2
—
—
—
0
0
8
49
1.64
0.62
1.0
1.2
—
84.29
—
0
7
18
130
1.39
0.61
4.3
2.1
0.00
0.00
g/l
-0.00
18
121
5
30
1.67
0.61
6.2
2.9
—
73860.50
—
0
6
46
381
1.22
0.61
1.3
1.2
121.01
171.53
iu/ml
0.37
19
151
22
166
1.34
0.59
1.0
1.1
—
—
—
0
0
8
53
1.52
0.58
1.4
1.2
—
—
—
0
0
6
35
1.72
0.58
3.0
1.9
—
—
—
0
0
6
35
1.72
0.58
3.0
1.9
—
—
—
0
0
18
132
1.37
0.57
4.3
2.1
0.00
0.00
g/l
-0.00
18
122
8
54
1.49
0.57
2.6
1.9
—
—
—
0
0
8
54
1.49
0.57
1.1
1.0
—
—
—
0
0
19
141
1.36
0.57
4.1
2.1
0.06
0.04
g/l
0.14
19
131
114
1027
1.13
0.56
3.5
3.9
629.06
460.18
ng/l
0.14
83
794
6
37
1.63
0.55
1.3
1.7
—
—
—
0
0
88
781
1.15
0.54
1.5
1.4
—
—
—
0
0
9
65
1.39
0.50
2.4
1.8
—
—
—
0
0
9
65
1.39
0.50
2.4
1.8
—
—
—
0
0
9
65
1.39
0.50
2.4
1.8
—
—
—
0
0
27
329
0.81
0.45
1.0
1.0
—
—
—
0
0
5
31
1.62
0.43
1.0
2.1
—
—
—
0
0
5
31
1.62
0.43
1.0
2.1
—
—
—
0
0
524
5346
0.92
0.42
4.7
4.3
1.41
1.46
mmol/l
1.86
476
4949
8
58
1.38
0.41
1.5
1.5
—
—
—
0
0
5
33
1.52
0.41
1.6
1.4
—
—
—
0
0
5
33
1.52
0.41
1.6
1.4
—
—
—
0
0
82
904
0.89
0.40
1.2
1.3
5.30
11.26
u/ml
1.12
26
364
5
34
1.47
0.40
9.8
3.1
—
—
—
0
0
5
35
1.43
0.39
1.2
1.4
0.72
1.04
g/l
—
5
35
20
247
0.80
0.38
2.3
1.9
—
—
—
0
0
9
67
1.35
0.38
1.0
1.1
—
—
—
0
0
19
152
1.26
0.37
1.4
1.4
—
—
—
0
0
5
78
0.64
0.36
1.4
1.5
—
—
—
0
0
144
1353
1.08
0.34
1.3
1.3
0.86
1.86
u/ml
1.46
28
339
15
118
1.28
0.33
2.0
1.5
—
—
—
0
0
141
1329
1.08
0.31
3.9
4.1
21.73
20.90
%
0.22
59
588
485
4941
0.94
0.31
23.6
16.7
15.77
14.70
%
2.78
479
4874
7
100
0.70
0.30
1.6
1.3
—
—
—
0
0
22
185
1.20
0.29
3.7
2.0
—
—
—
0
0
7
57
1.23
0.29
2.4
2.1
—
—
—
0
0
92
983
0.93
0.26
2.8
2.9
0.71
0.74
ug/l
0.11
63
628
116
1099
1.07
0.23
1.8
1.7
469.14
5429323.63
pmol/l
0.50
95
921
508
5008
1.05
0.23
6.1
5.6
39.50
39.77
mmol/mol
0.27
466
4674
33
296
1.12
0.21
1.4
1.3
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
32.29
—
0
6
0
11
0.00
0.21
0.0
1.9
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
1.73
—
0
6
0
12
0.00
0.21
0.0
1.0
—
25.63
—
0
12
0
13
0.00
0.21
0.0
1.0
—
—
—
0
0
17
145
1.18
0.20
1.5
1.4
241.25
270.77
u/ml
0.19
12
69
19
164
1.16
0.20
1.4
1.3
—
—
—
0
0
6
48
1.25
0.20
1.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.0
—
—
—
0
0
141
1466
0.95
0.18
1.7
1.7
1.45
1.39
mmol/l
0.28
122
1245
6
53
1.13
0.18
1.0
1.6
—
—
—
0
0
22
196
1.13
0.16
1.2
2.0
—
—
—
0
0
366
3711
0.97
0.13
3.2
3.2
—
—
—
0
0
39
417
0.93
0.13
3.0
3.3
340.90
216.10
ng/l
0.45
39
379
11
94
1.17
0.13
3.3
4.2
114.83
338.71
u/ml
0.40
11
88
16
143
1.12
0.11
1.7
1.3
—
—
—
0
0
32
300
1.07
0.10
5.2
2.8
0.06
0.16
e6/l
1.49
32
292
11
123
0.89
0.08
1.6
1.4
—
—
—
0
0
142
1393
1.02
0.07
3.3
2.8
333.16
6296.00
umol/l
4.82
122
1223
10
89
1.13
0.07
6.1
2.8
3.26
4.28
e9/l
—
10
89
67
690
0.97
0.07
2.1
1.8
1.53
1.48
%
0.19
56
613
14
128
1.10
0.06
1.0
1.2
0.28
3.44
u/ml
—
5
83
9
100
0.90
0.06
1.0
1.1
—
—
—
0
0
10
111
0.90
0.06
1.4
1.9
—
—
—
0
0
540
5381
1.02
0.04
4.6
4.3
4.57
4.65
mmol/l
1.15
493
5009
15
140
1.07
0.04
2.1
2.4
145.22
69.90
ug/min
—
9
81
10
91
1.10
0.04
6.9
3.3
52.40
57.03
%
—
10
91
518
5163
1.01
0.03
4.3
3.9
1.40
1.29
mmol/l
2.53
468
4751
53
539
0.98
0.02
4.0
3.3
—
—
—
0
0
546
5469
0.99
0.01
5.1
4.8
2.72
2.76
mmol/l
0.45
498
5062
93
924
1.01
0.00
1.2
1.3
47.38
34.57
iu/ml
0.21
18
304
15
147
1.02
0.00
1.2
1.4
—
—
—
0
0
17
172
0.99
0.00
1.2
1.3
—
—
—
0
0
53
527
1.01
0.00
4.0
4.5
177.46
32.98
ug/l
0.40
42
439
13
129
1.01
0.00
1.1
1.2
—
—
—
0
0
5
52
0.96
0.00
1.0
1.1
—
—
—
0
0
7
72
0.97
-0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
9.0
—
—
—
0
0
7
72
0.97
-0.00
2.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
2.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
8.1
—
—
—
0
0
7
70
1.00
-0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
71
0.99
-0.00
2.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
60
1.00
-0.00
2.7
2.1
19.22
17.64
ug/l
—
6
60
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
88
0.91
-0.00
1.4
1.1
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
70
1.00
-0.00
2.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTATROPHY and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTATROPHY | 1.873 [1.59, 2.2] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.028 |
During the follow-up period (1.1.1998 — 31.12.2019), 468 out of 2068 females with H7_OPTATROPHY died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTATROPHY | 2.259 [1.92, 2.65] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.005 |
During the follow-up period (1.1.1998 — 31.12.2019), 615 out of 2171 males with H7_OPTATROPHY died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTATROPHY.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.093% | 0.426% |
| 5 | 0.802% | 2.635% |
| 10 | 2.178% | 6.444% |
| 15 | 4.039% | 11.908% |
| 20 | 7.47% | 19.895% |
Relationships between endpoints
↥Index endpoint: H7_OPTATROPHY – Optic atrophy
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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