optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters: 2 out of 7 registries used, show all original rules. |
3574 |
4. Check minimum number of eventsNone |
3574 |
5. Include endpoints |
3892 |
6. Filter based on genotype QC (FinnGen only) |
3892 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- 2
- First used in FinnGen datafreeze
- DF2
Disorders of optic nerve and visual pathways
based on the number of shared cases.
Similar with more cases:
Similar with less cases:
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 27317 | 15860 | 11283 |
| Only index persons | 24341 | 14506 | 9835 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.40 | 0.45 | 0.32 |
| Only index persons | 0.47 | 0.53 | 0.38 |
| Median age at first event (years) | |||
| Whole population | 42.35 | 40.11 | 45.40 |
| Only index persons | 41.50 | 39.25 | 44.83 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 3892 | 2535 | 1357 |
| Unadjusted period prevalence (%) | 0.77 | 0.86 | 0.60 |
| Median age at first event (years) | 44.75 | 40.10 | 53.45 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 3473
- Matched controls
- 34729
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.3
ICD-10 Finland
Other disorders of optic disc
2104.5
323.0
397
*
L03AB07
ATC
interferon beta-1a; parenteral
104.9
323.0
366
39
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
91.3
323.0
574
75
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
9.6
323.0
918
1252
109
Kela drug reimbursment
Multiple sclerosis
90.8
323.0
693
95
H47.2
ICD-10 Finland
Optic atrophy
6184.5
323.0
537
*
XCK00
NOMESCO Finland
Perimetry
16.6
323.0
1036
866
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
323.0
597
*
H47.1
ICD-10 Finland
Papilloedema, unspecified
8565.0
323.0
700
*
G35
ICD-10 Finland
Multiple sclerosis
75.3
323.0
851
149
H46
ICD-10 Finland
Optic neuritis
10071.6
323.0
1308
*
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
93.4
323.0
611
79
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.5
323.0
1201
3043
TAB00
NOMESCO Finland
Lumbar puncture
11.2
307.1
619
662
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.7
258.2
729
1323
L03AX13
ATC
glatiramer acetate; parenteral
87.9
246.7
275
34
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
13.0
221.1
407
350
N86
ICPC
Multiple sclerosis
57.2
219.1
260
49
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.2
214.6
758
1776
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
49.8
213.0
259
56
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
11.2
195.3
387
385
H53.4
ICD-10 Finland
Visual field defects
16.7
187.0
308
201
164
Kela drug reimbursment
Fingolimod
112.8
186.3
202
19
XCD10
NOMESCO Finland
Electrophysiological examination of eye
13.0
185.9
341
288
XCK10
NOMESCO Finland
Photography of fundus of eye
5.0
182.8
661
1564
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.6
179.0
499
861
353
Kela drug reimbursment
Cladribine and fingolimod
116.5
163.8
177
16
G93.2
ICD-10 Finland
Benign intracranial hypertension
148.9
160.9
170
12
L04AX07
ATC
dimethyl fumarate; oral
66.5
158.0
183
29
L04AA27
ATC
fingolimod; oral
115.8
143.3
155
14
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
11.5
139.2
270
253
L04AA31
ATC
teriflunomide; oral
111.9
138.2
150
14
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
43.1
137.6
172
42
CS494
NOMESCO Finland
Other visual field testing
12.1
133.5
252
223
L03AB08
ATC
interferon beta-1b; parenteral
77.9
131.6
149
20
H53.1
ICD-10 Finland
Subjective visual disturbances
4.9
125.1
442
994
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.2
121.7
518
1401
N04BB01
ATC
amantadine; oral
12.8
112.5
206
170
N07XX09
ATC
[U] dimethyl fumarate; oral
72.4
110.3
126
18
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
+∞
108.9
104
*
S01EC01
ATC
acetazolamide; systemic
10.7
108.4
217
215
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
24.0
106.7
154
67
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
95.2
91
*
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
9.6
90.8
192
210
M03BX01
ATC
baclofen; systemic
10.0
84.8
175
183
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.4
80.8
432
1389
2AB04
NOMESCO Finland
NA
68.1
80.8
93
14
XA800
NOMESCO Finland
Neuropsychological investigation
4.6
78.3
290
673
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
119.9
76.2
82
7
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
17.4
75.6
121
72
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
8.5
69.8
158
194
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
10.4
69.7
140
139
AA1AD
NOMESCO Finland
CT of head and brain
2.2
66.6
829
4337
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
+∞
64.8
62
*
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.4
62.6
199
390
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
34.5
62.2
81
24
R51.80
ICD-10 Finland
Headache
2.3
58.2
651
3215
ZX120
NOMESCO Finland
Intravenous
2.8
58.1
411
1584
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
296.8
57.4
58
*
H47.7
ICD-10 Finland
Disorder of visual pathways, unspecified
556.8
55.7
55
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
7.0
54.7
140
208
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
70.0
54.3
62
9
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
56.4
51.7
61
11
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.8
51.6
1353
9190
XKD06
NOMESCO Finland
Physiologic investigation of micturition
5.1
51.3
169
345
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
25.1
49.0
69
28
N03AX12
ATC
gabapentin; oral
2.2
48.2
557
2769
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
10.2
46.8
94
94
L03AB13
ATC
peginterferon beta-1a; parenteral
59.8
45.4
53
9
4AA23
NOMESCO Finland
NA
158.7
44.9
47
*
N06BA07
ATC
modafinil; oral
19.2
44.5
68
36
H02AB06
ATC
prednisolone; systemic
1.7
44.3
1527
11089
36702
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica. Papillitis
+∞
43.8
42
*
H57.1
ICD-10 Finland
Ocular pain
3.9
43.3
189
509
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
10.0
42.3
86
88
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.8
42.1
294
1117
XKD00
NOMESCO Finland
Uroflowmetry
2.2
41.6
469
2293
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
6.1
40.8
114
191
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
9.6
40.6
84
89
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
20.3
40.1
60
30
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
6.6
40.0
105
162
E23.00
ICD-10 Finland
Panhypopituitarism
18.8
39.7
61
33
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
2.9
39.1
259
950
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.1
39.1
228
769
A02BC02
ATC
pantoprazole; systemic
1.6
38.9
2062
16556
ZXA10
NOMESCO Finland
Bilateral
1.9
38.7
642
3672
G04BD09
ATC
trospium; oral
5.1
38.6
127
259
N03AX16
ATC
pregabalin; oral
1.8
38.1
764
4663
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
7.6
36.8
88
119
H02AB04
ATC
methylprednisolone; systemic
2.0
36.4
505
2690
H02AB09
ATC
hydrocortisone; systemic
4.6
36.2
131
296
R20.2
ICD-10 Finland
Paraesthesia of skin
2.6
36.1
291
1198
H53.2
ICD-10 Finland
Diplopia
4.0
36.1
150
387
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
35.9
1236
8814
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
5.6
34.5
104
192
3773A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[PAPILLITIS OPTICA]
+∞
34.4
33
*
37799
ICD-8 Finland
Other diseases of retina and optic nerve, Unspecified
+∞
34.4
33
*
N03AE01
ATC
clonazepam; systemic
2.8
34.3
230
848
H04.10
ICD-10 Finland
Dry eye syndrome
2.3
33.9
355
1670
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.2
33.8
362
1722
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.1
33.4
406
2045
101
Kela drug reimbursment
Anterior pituitary hypofunction
9.3
32.5
68
74
UKC02
NOMESCO Finland
Cystoscopy
2.0
32.4
478
2602
D35.2
ICD-10 Finland
Benign neoplasm: Pituitary gland
7.4
31.6
76
104
34099
ICD-8 Finland
Multiple sclerosis
48.0
31.6
38
8
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
6.2
31.0
85
140
XKC03
NOMESCO Finland
Water cystometry
3.7
31.0
140
389
111
Kela drug reimbursment
Epilepsy and comparable convulsive disorders
2.7
30.9
216
820
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
30.8
925
6306
L04AX01
ATC
azathioprine; systemic
2.9
30.6
191
672
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
10.2
30.6
61
61
G04BD12
ATC
mirabegron; oral
2.3
30.5
313
1456
TPH04
NOMESCO Finland
Cathetrisation of vein
1.8
30.3
657
4073
R1250
NOMESCO Finland
Evaluation of functional capability
4.4
30.2
112
260
L04AA40
ATC
cladribine; oral
83.3
29.8
33
*
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
9.3
29.6
62
68
37790
ICD-8 Finland
Other diseases of retina and optic nerve, Atrophia (et degeneratio) nervi optici (tabica excepta)
+∞
29.2
28
*
N05CF01
ATC
zopiclone; oral
1.6
27.3
953
6713
SPAT1229
SPAT
Assessment of need for aid
2.4
27.1
245
1071
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.8
27.0
506
2983
H54.4
ICD-10 Finland
Blindness, monocular
20.2
26.9
40
20
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
4.1
26.6
106
264
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
8.2
26.3
59
73
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
5.4
26.1
80
152
H47.4
ICD-10 Finland
Disorders of optic chiasm
+∞
26.1
25
*
H54.7
ICD-10 Finland
Unspecified visual loss
9.0
25.4
54
61
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
6.2
25.4
69
113
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
15.9
25.4
41
26
G04BD04
ATC
oxybutynin; oral, transdermal
2.7
25.3
185
719
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
25.0
24
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.8
24.8
432
2480
H52.1
ICD-10 Finland
Myopia
3.1
24.8
143
480
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
2.5
24.7
205
856
9530/0-C70.0
ICD-O-3
Meningioma, NOS, of cerebral meninges
8.4
24.5
54
65
N02BE01
ATC
paracetamol; systemic, rectal
1.6
24.5
2772
24930
G40.9
ICD-10 Finland
Epilepsy, unspecified
3.0
24.0
143
490
R33
ICD-10 Finland
Retention of urine
2.4
23.9
218
957
TKC22
NOMESCO Finland
Catheterisation instruction
4.4
23.6
87
202
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
7.5
23.6
56
76
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
7.5
23.6
56
76
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.8
23.6
420
2427
XCH00
NOMESCO Finland
Eye pressure measurement
3.1
23.5
135
452
PAW37
NOMESCO Finland
Biopsy of temporal artery
8.6
23.0
50
59
182
Kela drug reimbursment
Brivaracetam, eslikarbazepin, gabapentin, lacosamide, levetiracetam, perampanel, pregabalin, tiagabin and zonisamide
3.9
22.9
96
252
N03AF02
ATC
oxcarbazepine; oral
3.0
22.7
135
461
R42
ICD-10 Finland
Dizziness and giddiness
1.6
22.5
630
4166
R35
ICD-10 Finland
Polyuria
2.4
22.5
200
867
G91.0
ICD-10 Finland
Communicating hydrocephalus
11.2
22.4
42
38
N03AX14
ATC
levetiracetam; systemic
3.4
22.2
111
336
R4110
NOMESCO Finland
Physiotherapy
1.5
22.1
791
5558
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
9.9
22.0
44
45
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
6.5
21.9
57
89
R50.9
ICD-10 Finland
Fever, unspecified
1.7
21.8
453
2751
AAE10
NOMESCO Finland
Transsphenoidal total or partial excision of intracranial lesion
9.7
21.8
44
46
G91.1
ICD-10 Finland
Obstructive hydrocephalus
11.5
21.7
40
35
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
3.7
21.5
95
261
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
15.4
21.5
35
23
N03AF01
ATC
carbamazepine; oral, rectal
2.5
21.2
172
711
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
21.1
835
5995
H34.1
ICD-10 Finland
Central retinal artery occlusion
9.1
21.0
44
49
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
12.0
21.0
38
32
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
6.7
20.9
53
80
37791
ICD-8 Finland
Other diseases of retina and optic nerve, Papilloedema. Stasis papillae
+∞
20.8
20
*
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
1.9
20.8
334
1857
F05
ICPC
Visual disturbance other
3.2
20.7
110
350
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
20.6
833
6004
J01EA01
ATC
trimethoprim; systemic
1.5
20.4
781
5558
A02BC01
ATC
omeprazole; systemic
1.5
20.4
802
5742
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
14.3
20.3
34
24
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
20.2
469
2934
H53.8
ICD-10 Finland
Other visual disturbances
5.4
20.0
60
112
N02AX02
ATC
tramadol; systemic, rectal
1.4
19.9
1189
9269
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
14.5
19.8
33
23
TKC20
NOMESCO Finland
Catheterisation of bladder
2.2
19.8
209
985
R4150
NOMESCO Finland
Neuropsychological rehabilitation
6.3
19.7
52
83
XCD20
NOMESCO Finland
Photoangiography of eye
4.4
19.7
72
167
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
19.6
217
1044
102
Kela drug reimbursment
Diabetes insipidus
16.5
19.6
31
19
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
19.5
19.5
29
15
H54.1
ICD-10 Finland
Severe visual impairment, binocular
21.7
19.5
28
13
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
19.3
384
2297
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
2.6
19.2
146
583
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.8
19.1
348
2021
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
5.6
19.0
55
99
N28
ICPC
Limited function/disability (N)
4.6
18.9
66
146
D32.9
ICD-10 Finland
Benign neoplasm: Meninges, unspecified
11.4
18.9
35
31
3771A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic atrophy
+∞
18.8
18
*
H47
ICD-10 Finland
Other disorders of optic [2nd] nerve and visual pathways
+∞
18.8
18
*
114
Kela drug reimbursment
Glaucoma
2.1
18.7
219
1081
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
23.8
18.6
26
11
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
5.2
18.6
58
114
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.5
18.5
656
4572
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
10.7
18.4
35
33
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
1.9
17.8
260
1398
R56.8
ICD-10 Finland
Other and unspecified convulsions
2.3
17.7
174
793
M03BX02
ATC
tizanidine; oral
1.4
17.7
1913
16422
XF400
NOMESCO Finland
ECG with 12 standard connections
1.6
17.6
456
2933
H02AB07
ATC
prednisone; oral
1.7
17.6
424
2677
R4120
NOMESCO Finland
Occupational therapy
2.1
17.6
211
1047
G04BD07
ATC
tolterodine; oral
2.4
17.5
154
665
H34.8
ICD-10 Finland
Other retinal vascular occlusions
3.8
17.5
74
197
A28
ICPC
Limited function/disability NOS
1.7
17.4
367
2231
G04BD08
ATC
solifenacin; oral
2.2
17.3
188
896
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.1
17.2
206
1024
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.2
17.2
176
819
A02BC03
ATC
lansoprazole; oral
1.5
17.1
812
6019
D35.30
ICD-10 Finland
Craniopharyngoma
31.6
17.0
22
7
L28
ICPC
Limited function/disability (L)
1.7
16.9
412
2608
WX110
NOMESCO Finland
Local anesthesy
1.4
16.8
2241
19819
H47.6
ICD-10 Finland
Disorders of visual cortex
+∞
16.7
16
*
N06AA09
ATC
amitriptyline; systemic
1.8
16.4
281
1598
G40.29
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with complex partial seizures
3.4
16.4
78
230
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.4
16.3
1191
9532
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
5.7
16.3
46
81
N06AX16
ATC
venlafaxine; oral
1.6
16.1
445
2913
S01ED51
ATC
timolol, combinations; ophthalmic
2.1
16.0
186
912
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
7.2
16.0
38
53
N05BA09
ATC
clobazam; oral
6.2
15.9
42
68
H25.1
ICD-10 Finland
Senile nuclear cataract
1.5
15.8
530
3635
N06AX21
ATC
duloxetine; oral
1.7
15.7
323
1944
A06AD11
ATC
lactulose; oral
1.7
15.7
357
2216
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
4.1
15.6
61
152
G44.2
ICD-10 Finland
Tension-type headache
1.6
15.5
424
2766
H26.4
ICD-10 Finland
After-cataract
1.9
15.4
217
1151
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.6
15.3
69
195
G81.9
ICD-10 Finland
Hemiplegia, unspecified
4.8
15.2
50
105
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
9.2
15.2
31
34
WX882
NOMESCO Finland
High dependency care
2.7
15.1
102
381
H54.0
ICD-10 Finland
Blindness, binocular
20.1
15.1
22
11
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
5.8
15.1
42
73
G40.22
ICD-10 Finland
Complex partial epileptic seizure with secondary generalization
3.2
15.0
78
246
H34.2
ICD-10 Finland
Other retinal artery occlusions
8.9
14.9
31
35
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
15.1
14.9
24
16
N03AX11
ATC
topiramate; oral
2.6
14.7
104
400
AA7AA
NOMESCO Finland
Liquor cerebri shunt X-ray examinatin without contrast
13.2
14.7
25
19
C03CA01
ATC
furosemide; systemic
1.5
14.5
653
4766
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
1.6
14.4
396
2583
J01DA01
ATC
[U] cefalexin; systemic
1.3
14.4
1939
16960
SPAT1216
SPAT
Assessment of functional ability
1.6
14.4
388
2523
S01EE01
ATC
latanoprost; ophthalmic
2.2
14.3
150
704
N06AB04
ATC
citalopram; systemic
1.5
14.3
628
4560
D32.0
ICD-10 Finland
Benign neoplasm: Cerebral meninges
11.4
14.3
26
23
H40.11
ICD-10 Finland
Low pressure glaucoma
3.7
14.2
62
171
J01MA02
ATC
ciprofloxacin; systemic
1.4
14.2
1070
8564
H30.2
ICD-10 Finland
Posterior cyclitis
8.6
14.2
30
35
J01AA02
ATC
doxycycline; systemic
1.3
14.2
2387
21559
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.4
14.1
1104
8890
G04CA02
ATC
tamsulosin; oral
1.5
14.0
455
3093
N29
ICPC
Neurological sympt/complt other
3.2
14.0
74
237
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
14.0
609
4411
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
13.9
1235
10131
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.4
13.8
773
5873
A02BA02
ATC
ranitidine; systemic
1.5
13.6
515
3623
H20.1
ICD-10 Finland
Chronic iridocyclitis
4.0
13.6
54
138
36709
ICD-8 Finland
Inflammation of optic nerve and retina, Unspecified
+∞
13.5
13
*
XCW12
NOMESCO Finland
Assessment of colour vision
+∞
13.5
13
*
XKD03
NOMESCO Finland
Urethral pressure profilometry
2.9
13.5
80
277
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.5
13.5
582
4206
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.1
13.5
150
726
N05BA01
ATC
diazepam; systemic, rectal
1.6
13.4
367
2389
CS2P4
NOMESCO Finland
Optic nerve head imaging
6.5
13.4
34
53
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
18.3
13.4
20
11
N03AX09
ATC
lamotrigine; oral
2.0
13.2
170
873
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.8
13.2
213
1190
C10AC01
ATC
colestyramine; oral
2.6
13.1
93
358
D44.3
ICD-10 Finland
Neoplasm of uncertain or unknown behaviour: Pituitary gland
11.0
13.0
24
22
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
11.0
13.0
24
22
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
2.9
12.8
77
270
H03AA01
ATC
levothyroxine sodium; systemic
1.4
12.8
661
4941
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
12.8
681
5121
SPAT1153
SPAT
Removal of sutures
1.4
12.8
847
6613
N39.4
ICD-10 Finland
Other specified urinary incontinence
1.8
12.7
220
1255
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.3
12.7
62
188
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
9.0
12.7
26
29
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
9.7
12.7
25
26
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
3.9
12.7
51
132
H01AC01
ATC
somatropin; parenteral
6.8
12.7
31
46
G50.0
ICD-10 Finland
Trigeminal neuralgia
3.2
12.6
64
200
N99
ICPC
Neurological disease other
3.9
12.6
50
128
L01BB04
ATC
cladribine; systemic
70.1
12.6
14
*
SPAT1231
SPAT
Assessment of adjustments needed in living environment
3.3
12.6
63
195
H48.1*A69.2
ICD-10 Finland
Retrobulbar neuritis in Lyme disease
+∞
12.5
12
*
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
12.5
12
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.2
12.5
126
585
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
12.4
856
6725
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.0
12.3
165
861
N03AG01
ATC
valproic acid; systemic, rectal
1.8
12.3
196
1090
J01FF01
ATC
clindamycin; systemic
1.4
12.2
772
5973
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.1
12.2
135
650
WYA30
NOMESCO Finland
Preparations for expected poor cooperation
1.7
12.1
258
1572
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
2.6
12.0
87
341
WX404
NOMESCO Finland
Intravenous generell anesthesy
1.4
12.0
602
4475
J01CA08
ATC
pivmecillinam; oral
1.3
11.9
1224
10201
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
6.8
11.9
29
43
N30.0
ICD-10 Finland
Acute cystitis
1.5
11.8
401
2751
R1230
NOMESCO Finland
Neuropsychological evaluation of need and possibilities to rehabilitation
3.8
11.8
48
126
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
2.0
11.6
138
689
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
22.9
11.6
16
7
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
3.8
11.5
48
129
H47.5
ICD-10 Finland
Disorders of other visual pathways
+∞
11.5
11
*
M31.6
ICD-10 Finland
Other giant cell arteritis
13.6
11.4
19
14
SPAT1301
SPAT
No procedures
1.3
11.4
909
7285
4AA36
NOMESCO Finland
NA
120.4
11.4
12
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
2.2
11.4
115
533
L04AA06
ATC
mycophenolic acid; systemic
3.0
11.3
65
220
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.2
11.3
117
547
R06.0
ICD-10 Finland
Dyspnoea
1.4
11.3
649
4931
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
3.2
11.3
57
178
RF120
NOMESCO Finland
NA
3.8
11.3
46
121
J01DB01
ATC
cefalexin; oral
1.3
11.3
2620
24271
R3120
NOMESCO Finland
Training in mobility skills
15.1
11.3
18
12
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
2.6
11.3
82
321
F79.0
ICD-10 Finland
Unspecified mental retardation, with the statement of no, or minimal, impairment of behaviour
8.3
11.3
24
29
EB1AA
NOMESCO Finland
Tooth X-ray examination
1.3
11.3
1677
14648
WX892
NOMESCO Finland
Monitored bed care
1.8
11.2
209
1223
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
1.6
11.2
333
2210
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.5
11.2
353
2381
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.7
11.2
239
1459
CKC12
NOMESCO Finland
Photocoagulation of retina
2.2
11.1
118
558
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
25.1
11.1
15
6
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.3
11.1
863
6888
Q85.00
ICD-10 Finland
Neurofibromatosis, type 1
20.1
11.1
16
8
M79.6
ICD-10 Finland
Pain in limb
1.3
11.0
1001
8176
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.4
11.0
770
6046
183
Kela drug reimbursment
Lamotrigin and topiramate
3.8
10.9
45
120
H40.13
ICD-10 Finland
Chronic glaucoma with open ventricular angle
2.2
10.9
106
484
ZXA00
NOMESCO Finland
Right side
1.4
10.8
692
5355
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.5
10.8
452
3237
S06.0
ICD-10 Finland
Concussion
1.6
10.8
286
1850
ZXC95
NOMESCO Finland
Use of surgical navigator
3.5
10.8
48
137
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
10.7
381
2637
G51.0
ICD-10 Finland
Bell palsy
2.6
10.7
77
303
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
2.2
10.7
105
481
H50.1
ICD-10 Finland
Divergent concomitant strabismus
4.3
10.6
38
89
N06AX11
ATC
mirtazapine; oral
1.3
10.6
888
7159
A06AC01
ATC
ispaghula (psylla seeds); oral
1.4
10.6
635
4856
N03AB02
ATC
phenytoin; systemic
4.2
10.6
39
94
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
1.8
10.5
170
950
M05BA04
ATC
alendronic acid; oral
1.8
10.5
183
1050
3774A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic nerve
+∞
10.4
10
*
S01EC04
ATC
brinzolamide; ophthalmic
2.4
10.3
86
364
G03.9
ICD-10 Finland
Meningitis, unspecified
8.2
10.3
22
27
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
10.6
10.3
19
18
H52.0
ICD-10 Finland
Hypermetropia
2.8
10.2
65
238
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.6
10.2
263
1685
R01AD09
ATC
mometasone; nasal
1.3
10.2
1352
11585
SFA10
NOMESCO Finland
Fillning on one surface of tooth
1.3
10.1
1627
14273
Z50.1
ICD-10 Finland
Other physical therapy
1.9
10.1
145
778
R60.0
ICD-10 Finland
Localized oedema
1.6
10.0
269
1742
R13
ICD-10 Finland
Dysphagia
1.8
10.0
164
922
WX002
NOMESCO Finland
Sedation and analgesia
1.4
10.0
499
3694
H25.0
ICD-10 Finland
Senile incipient cataract
2.0
10.0
130
671
SPAT1262
SPAT
Handing over of treatment supplies
1.4
10.0
462
3373
RS222
NOMESCO Finland
NA
3.2
10.0
50
157
SFA20
NOMESCO Finland
Filling on two surfaces of tooth
1.3
9.9
1754
15548
SPAT1254
SPAT
Administration of medicine
1.5
9.9
394
2796
XA412
NOMESCO Finland
VEP
26.1
9.8
13
5
K02.1
ICD-10 Finland
Caries of dentine
1.3
9.8
1782
15839
WZC00
NOMESCO Finland
Planning of intervention or health care consultation
1.3
9.8
962
7921
9530/0-C70.9
ICD-O-3
Meningioma, NOS, of meninges, NOS
9.5
9.7
19
20
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.6
9.7
234
1476
PA6AE
NOMESCO Finland
Ulrasound examination of neck vasculature
3.9
9.7
38
98
S01EA05
ATC
brimonidine; ophthalmic (sympathomimetics in glaucoma therapy)
2.7
9.7
65
245
W19
ICD-10 Finland
Unspecified fall
1.6
9.6
246
1575
RS221
NOMESCO Finland
NA
2.9
9.6
57
201
H40.5
ICD-10 Finland
Glaucoma secondary to other eye disorders
3.8
9.6
39
104
R4160
NOMESCO Finland
Other therapy enhancing rehabilitation
2.5
9.5
70
280
R4190
NOMESCO Finland
Nutritional therapy
2.0
9.5
116
586
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
2.9
9.5
57
202
R2120
NOMESCO Finland
Counselling and guidance concerning rehabilitation services and social security
4.1
9.5
35
85
M54.9
ICD-10 Finland
Dorsalgia, unspecified
1.5
9.5
296
1990
S01ED01
ATC
timolol; ophthalmic
2.3
9.5
84
370
SPAT1148
SPAT
Treatment of chronic ulcer or burn
1.5
9.4
320
2190
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
1.4
9.4
483
3592
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.3
9.4
1301
11174
J01MA12
ATC
levofloxacin; systemic
1.4
9.4
460
3390
SPAT1263
SPAT
Sampling
1.3
9.4
1246
10650
H54.5
ICD-10 Finland
Severe visual impairment, monocular
6.2
9.4
24
39
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
1.6
9.3
253
1648
SAA01
NOMESCO Finland
Simple examination of mouth
1.3
9.3
2236
20481
M03BC01
ATC
orphenadrine (citrate); systemic
1.3
9.2
671
5281
ZXA05
NOMESCO Finland
Left side
1.3
9.2
624
4863
R11
ICD-10 Finland
Nausea and vomiting
1.6
9.2
227
1441
L02
ICPC
Back symptom/complaint
1.6
9.2
255
1669
UDH02
NOMESCO Finland
Rhinopharyngoscopy
1.7
9.1
183
1098
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
1.8
9.1
165
957
CA1ME
NOMESCO Finland
Ultrasound oculometry
4.8
9.1
29
61
A49.9
ICD-10 Finland
Bacterial infection, unspecified
1.6
9.1
253
1655
AA4BG
NOMESCO Finland
MRI examination of sella turcica with high intensity magnet
7.7
9.1
20
26
WYA05
NOMESCO Finland
Emergency visit or other similar visit involving procedures
1.2
9.0
1458
12734
WW400
NOMESCO Finland
Plasmaferesis
10.0
9.0
17
17
RK110
NOMESCO Finland
NA
3.9
9.0
35
90
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
4.2
9.0
32
76
N03AX18
ATC
lacosamide; systemic
4.5
8.9
30
67
6BA02
NOMESCO Finland
NA
6.5
8.9
22
34
A04
ICPC
Weakness/tiredness general
1.5
8.9
357
2533
U05
ICPC
Urination problems other
2.0
8.8
111
570
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
6.8
8.8
21
31
H25.8
ICD-10 Finland
Other senile cataract
1.6
8.8
214
1356
PA2BC
NOMESCO Finland
Cerebral extensive angiography with X-ray
3.7
8.7
36
98
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.5
8.7
263
1759
G82.2
ICD-10 Finland
Paraplegia, unspecified
6.6
8.6
21
32
P85
ICPC
Mental retardation
7.6
8.6
19
25
SPAT1222
SPAT
Counselling/guidance promoting independent living
1.4
8.6
355
2534
G93.0
ICD-10 Finland
Cerebral cysts
6.1
8.6
22
36
S01EE05
ATC
tafluprost; ophthalmic
2.3
8.6
75
329
N01
ICPC
Headache
1.5
8.5
326
2288
G40.19
ICD-10 Finland
Localization-related (focal)(partial) symptomatic epilepsy and epileptic syndromes with simple partial seizures
4.4
8.5
29
66
NK6MA
NOMESCO Finland
Measurement of bone age from hand and elbow using X-ray
3.7
8.5
35
95
B99
ICD-10 Finland
Other and unspecified infectious diseases
2.7
8.5
54
199
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
1.6
8.5
204
1289
AAC00
NOMESCO Finland
Ligature of intracranial aneurysm
3.7
8.4
35
96
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.4
8.4
491
3729
N05BA04
ATC
oxazepam; oral
1.3
8.4
673
5366
C07AB07
ATC
bisoprolol; oral
1.3
8.4
1134
9682
3770A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Papilloedema
+∞
8.3
8
*
3772A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic disk
+∞
8.3
8
*
H50.0
ICD-10 Finland
Convergent concomitant strabismus
3.9
8.3
32
82
S18
ICPC
Laceration/cut
1.3
8.3
1103
9391
SFA30
NOMESCO Finland
Filling on tree or more surfaces of tooth
1.3
8.2
1112
9485
H43.1
ICD-10 Finland
Vitreous haemorrhage
2.4
8.2
65
272
U07
ICPC
Urine symptom/complaint other
1.7
8.2
150
875
WX290
NOMESCO Finland
Other blockade of nerve
1.2
8.2
1364
11911
J45.9
ICD-10 Finland
Asthma, unspecified
1.4
8.2
473
3587
AA1AA
NOMESCO Finland
Head X-ray examination
4.2
8.2
29
69
H53.0
ICD-10 Finland
Amblyopia ex anopsia
3.4
8.2
37
109
F43.29
ICD-10 Finland
Adaptation disorder UNS
2.3
8.1
70
306
H81.1
ICD-10 Finland
Benign paroxysmal vertigo
1.6
8.1
230
1512
H40.9
ICD-10 Finland
Glaucoma, unspecified
3.0
8.1
44
148
9350/1-C75.2
ICD-O-3
Craniopharyngioma, NOS, of craniopharyngeal duct
33.4
8.1
10
*
J01CA04
ATC
amoxicillin; systemic
1.3
8.1
2615
24551
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.4
8.0
474
3606
AWB00
NOMESCO Finland
Reoperation for superficial infection in surgery of the nervous system
10.0
8.0
15
15
H35.5
ICD-10 Finland
Hereditary retinal dystrophy
5.3
8.0
23
44
M01AX17
ATC
nimesulide; oral
1.3
8.0
574
4505
RD210
NOMESCO Finland
NA
2.3
8.0
68
295
WX872
NOMESCO Finland
Intensive care
1.9
7.9
114
616
N02AA05
ATC
oxycodone; systemic
1.5
7.9
317
2249
C08CA01
ATC
amlodipine; oral
1.3
7.9
796
6541
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
1.7
7.9
154
917
R02
ICPC
Shortness of breath/dyspnoea
1.5
7.8
299
2100
R39.1
ICD-10 Finland
Other difficulties with micturition
2.3
7.8
70
313
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.3
7.8
67
293
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
2.9
7.8
45
157
E03.9
ICD-10 Finland
Hypothyroidism, unspecified
1.5
7.7
302
2135
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
1.2
7.7
1386
12181
2132
FHL
Ventricular operators sunt
45.1
7.7
9
*
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
45.1
7.7
9
*
Q87.88
ICD-10 Finland
Other specified congenital malformation syndromes, not elsewhere classified
15.0
7.7
12
8
SPAT1296
SPAT
Other function in accordance with occupational therapy nomenclature
3.2
7.7
38
120
UDM02
NOMESCO Finland
Sinoscopy
2.4
7.7
63
267
A02BC05
ATC
esomeprazole; systemic
1.2
7.7
1088
9316
Z87.1
ICD-10 Finland
Personal history of diseases of the digestive system
1.2
7.7
1212
10502
J01MA06
ATC
norfloxacin; oral
1.4
7.6
351
2555
A01
ICPC
Pain general/multiple sites
1.6
7.6
192
1230
E89.30
ICD-10 Finland
Postprocedural hypopituitarism
18.4
7.6
11
6
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
2.9
7.6
44
154
3313A
ICD-9 Finland
Other cerebral degenerations, Communicating hydrocephalus
25.1
7.6
10
*
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.5
7.5
290
2042
G80.1
ICD-10 Finland
Spastic diplegic cerebral palsy
8.9
7.5
15
17
A03FA01
ATC
metoclopramide; systemic, rectal
1.3
7.5
538
4215
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
3.2
7.5
37
117
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.3
7.5
837
6968
Z01.1
ICD-10 Finland
Examination of ears and hearing
1.4
7.4
335
2430
R05FA02
ATC
opium derivatives and expectorants; systemic
1.2
7.4
1118
9627
S01EE03
ATC
bimatoprost; ophthalmic
2.6
7.4
52
204
2133
FHL
Suntin revisio
80.3
7.4
8
*
M54.5
ICD-10 Finland
Low back pain
1.3
7.4
902
7585
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
1.5
7.4
220
1464
R03CA02
ATC
ephedrine; oral
13.4
7.4
12
9
181
Kela drug reimbursment
Retigabine and vigabatrin
13.4
7.4
12
9
E23.2
ICD-10 Finland
Diabetes insipidus
7.6
7.4
16
21
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.0
7.3
88
443
SFC01
NOMESCO Finland
Adjuvant procedure of filling therapy
1.3
7.3
719
5882
KA1AE
NOMESCO Finland
Kidney ultrasound examination
2.2
7.3
67
302
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.3
7.3
64
282
H52.2
ICD-10 Finland
Astigmatism
2.4
7.3
56
232
3773X
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS OPTICA ALIA SEU NUD]
+∞
7.3
7
*
RL140
NOMESCO Finland
NA
6.8
7.3
17
25
G03BA03
ATC
testosterone; systemic, rectal, sublingual, transdermal
1.8
7.3
114
635
NA3CG
NOMESCO Finland
Lumbar spine extensive MRI examination with high intensity magnet
1.9
7.2
98
518
PA2AD
NOMESCO Finland
CT angiography of brain
5.1
7.2
21
41
TCG40
NOMESCO Finland
Measurement of higher-grade errors of refraction
5.1
7.2
21
41
R06AE09
ATC
levocetirizine; oral
1.4
7.2
412
3114
Z43.5
ICD-10 Finland
Attention to cystostomy
6.2
7.2
18
29
E23.09
ICD-10 Finland
Pituitary insufficiency NOS
15.8
7.2
11
7
R51
ICD-10 Finland
Headache
1.7
7.2
154
943
RF420
NOMESCO Finland
NA
2.9
7.2
42
148
B01AB05
ATC
enoxaparin; parenteral
1.3
7.2
746
6148
CA1BM
NOMESCO Finland
Eye and orbita MRI examination with 3 Tesla magnet
30.1
7.1
9
*
9380/3-C71.9
ICD-O-3
Glioma, malignant of brain, NOS
30.1
7.1
9
*
EB1WA
NOMESCO Finland
NA
4.8
7.1
22
46
ABD40
NOMESCO Finland
Implantation of spinal injection device
20.0
7.1
10
5
NA1BM
NOMESCO Finland
Cervical spine MRI examination with 3 Tesla magnet
7.9
7.1
15
19
WX100
NOMESCO Finland
Conjunctival surface anesthesia
1.5
7.1
221
1489
H53
ICD-10 Finland
Visual disturbances
3.6
7.1
30
85
G96.0
ICD-10 Finland
Cerebrospinal fluid leak
8.8
7.0
14
16
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
3.3
7.0
33
101
E0000UV
ATC
NA
1.2
7.0
1128
9774
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
1.8
6.9
102
559
D07BA04
ATC
hydrocortisone and antiseptics; topical
1.4
6.9
279
1986
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
2.2
6.9
67
312
TAW99
NOMESCO Finland
Other minor neurosurgical procedure
4.2
6.9
24
57
N05BA12
ATC
alprazolam; oral
1.5
6.9
258
1809
AA1AM
NOMESCO Finland
Short MRI examination of brain with 3 Tesla magnet
7.5
6.9
15
20
AAG50
NOMESCO Finland
Stereotactic intracranial radiotherapy
4.6
6.9
22
48
J45
ICD-10 Finland
Asthma
1.5
6.9
252
1758
E66.01
ICD-10 Finland
Obesity due to excess calories
1.5
6.9
223
1516
G80.9
ICD-10 Finland
Cerebral palsy, unspecified
8.3
6.8
14
17
R53
ICD-10 Finland
Malaise and fatigue
1.3
6.8
542
4313
D33.00
ICD-10 Finland
Medial pilosytic astrocytoma of the cerebrum
10.9
6.8
12
11
G80.2
ICD-10 Finland
Spastic hemiplegic cerebral palsy
10.9
6.8
12
11
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
1.2
6.8
1529
13695
M05BX04
ATC
denosumab; parenteral
1.8
6.8
106
590
N06AB10
ATC
escitalopram; oral
1.3
6.8
579
4651
D32.03
ICD-10 Finland
Benign meningioma in ventricles
9.3
6.8
13
14
G04BD11
ATC
fesoterodine; oral
2.1
6.8
71
342
CKC15
NOMESCO Finland
Panretinal photocoagulation
3.6
6.8
28
78
XCH05
NOMESCO Finland
Eye pressure longterm registration
3.6
6.8
28
78
NA1AD
NOMESCO Finland
Cervical spine CT examination
1.9
6.8
100
547
2273A
ICD-9 Finland
Benign neoplasm of other endocrine glands and related structures, Pituitary gland and craniopharyngeal duct (pouch)
16.7
6.7
10
6
J01FA10
ATC
azithromycin; systemic
1.2
6.7
1784
16225
R07.4
ICD-10 Finland
Chest pain, unspecified
1.3
6.7
642
5234
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.6
6.6
171
1103
SAA04
NOMESCO Finland
Special inverstigation of mouth
1.6
6.6
153
957
Z71.8
ICD-10 Finland
Other specified counselling
1.3
6.6
674
5535
EBA15
NOMESCO Finland
Extraction of large number of teeth
1.9
6.6
93
502
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
12.3
6.6
11
9
L17
ICPC
Foot/toe symptom/complaint
1.3
6.6
653
5349
R51.81
ICD-10 Finland
Facial pain NOS
2.1
6.5
67
320
G40.12
ICD-10 Finland
Simple partial seizures with secondary generalization
3.3
6.5
30
91
N03AG04
ATC
vigabatrin; oral
10.0
6.5
12
12
WZA90
NOMESCO Finland
Other doctors statement
1.3
6.5
639
5223
H52.5
ICD-10 Finland
Disorders of accommodation
6.8
6.5
15
22
SPAT1104
SPAT
Monitoring of emergency patient
1.6
6.5
160
1020
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
1.5
6.5
194
1297
S97
ICPC
Chronic ulcer skin
1.7
6.5
118
691
H16.0
ICD-10 Finland
Corneal ulcer
1.7
6.5
120
708
I10
ICD-10 Finland
Essential (primary) hypertension
1.2
6.5
1328
11767
H05.2
ICD-10 Finland
Exophthalmic conditions
6.2
6.5
16
26
N06AB06
ATC
sertraline; oral
1.4
6.4
301
2199
EP1AE
NOMESCO Finland
Neck ultrasound examination
1.6
6.4
140
865
J01FA06
ATC
roxithromycin; oral
1.2
6.4
1113
9698
U13
ICPC
Bladder symptom/complaint other
2.0
6.4
77
392
CK2K4
NOMESCO Finland
Red-free imaging of ocular fundus
7.4
6.4
14
19
AAF15
NOMESCO Finland
Ventriculoatrial shunt
7.4
6.4
14
19
CA1AD
NOMESCO Finland
Orbita CT
7.4
6.4
14
19
Q85.09
ICD-10 Finland
Unspecified neurofibromatosis
14.3
6.4
10
7
Z03.80
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.4
91
492
WZC05
NOMESCO Finland
Specialty-specific consultation based on referral by dentist or doctor
1.6
6.4
146
915
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
2.2
6.4
58
263
UDQ12
NOMESCO Finland
Flexible laryngoscopy
1.7
6.4
129
779
D32.01
ICD-10 Finland
Benign tumor of meninges on interhemispheric surface
4.9
6.3
19
39
R4130
NOMESCO Finland
Speech therapy
2.2
6.3
60
276
G47.3
ICD-10 Finland
Sleep apnoea
1.3
6.3
501
3978
E66.8
ICD-10 Finland
Other obesity
1.6
6.3
147
925
WX704
NOMESCO Finland
Intubation
1.5
6.3
181
1196
M54.3
ICD-10 Finland
Sciatica
1.6
6.3
142
886
G91.8
ICD-10 Finland
Other hydrocephalus
11.0
6.3
11
10
F79.9
ICD-10 Finland
Unspecified mental retardation, without mention of impairment of behaviour
11.0
6.3
11
10
R62.0
ICD-10 Finland
Delayed milestone
3.5
6.3
27
78
RT150
NOMESCO Finland
NA
4.6
6.3
20
44
E22.80
ICD-10 Finland
Central precocious puberty
18.0
6.3
9
5
JC2KB
NOMESCO Finland
Functional X-ray examination of swallowing
3.0
6.3
33
111
G37.0
ICD-10 Finland
Diffuse sclerosis
+∞
6.2
6
*
SPAT1234
SPAT
Support of social functional capacity
1.7
6.2
114
668
B01AC04
ATC
clopidogrel; oral
1.4
6.2
301
2212
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
1.5
6.2
185
1236
G45.3
ICD-10 Finland
Amaurosis fugax
2.6
6.2
42
164
Q85.01
ICD-10 Finland
Neurofibromatosis, type 2
26.7
6.2
8
*
D33.39
ICD-10 Finland
Benign tumor of the cranial nerves UNS
26.7
6.2
8
*
G50.1
ICD-10 Finland
Atypical facial pain
2.4
6.2
49
208
SAA02
NOMESCO Finland
Basic examination of mouth
1.2
6.2
2021
18670
G40.20
ICD-10 Finland
Complex partial seizures with only alteration of consciousness
2.8
6.2
37
134
H40.10
ICD-10 Finland
Capsular glaucoma with pseudoexfoliation on the anterior lens capsule
2.4
6.2
48
201
XF600
NOMESCO Finland
Bloodpressure measurement
1.6
6.2
158
1015
PA6BG
NOMESCO Finland
MRI examination of neck vasculature with high intensity magnet
4.1
6.2
22
54
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
2.5
6.2
44
175
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
1.4
6.2
254
1813
S01EE04
ATC
travoprost; ophthalmic
2.4
6.2
48
202
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
1.7
6.2
110
643
J01DA09
ATC
[U] cefadroxil; inhalant, oral
1.2
6.1
746
6253
U02
ICPC
Urinary frequency/urgency
1.4
6.1
331
2482
J02AC01
ATC
fluconazole; systemic
1.2
6.1
1192
10493
E000001
ATC
NA
1.3
6.1
561
4546
H26.2
ICD-10 Finland
Complicated cataract
2.8
6.1
36
129
Z94.0
ICD-10 Finland
Kidney transplant status
2.7
6.1
37
136
AA5PD
NOMESCO Finland
CT examination of brain pefusion
3.5
6.1
26
75
9531/0-C70.0
ICD-O-3
Meningothelial meningioma of cerebral meninges
12.5
6.1
10
8
CEC60
NOMESCO Finland
Transposition of extraocular muscle with adjustable suture
12.5
6.1
10
8
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
1.7
6.1
109
637
H10.3
ICD-10 Finland
Acute conjunctivitis, unspecified
1.6
6.0
155
997
G40.21
ICD-10 Finland
Partial epileptic seizure with cloudiness and automatism
4.4
6.0
20
46
D80.1
ICD-10 Finland
Nonfamilial hypogammaglobulinaemia
6.7
6.0
14
21
301
Kela drug reimbursment
Growth hormone
6.7
6.0
14
21
D64.9
ICD-10 Finland
Anaemia, unspecified
1.5
6.0
207
1427
WX140
NOMESCO Finland
Parabulbar anesthesy
1.8
6.0
90
496
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.3
6.0
413
3216
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTNERVE and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNERVE | 1.564 [1.39, 1.75] | < 0.001 |
| Birth year | 0.995 [0.99, 1.0] | 0.218 |
During the follow-up period (1.1.1998 — 31.12.2019), 1571 out of 11910 females with H7_OPTNERVE died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNERVE | 1.746 [1.56, 1.95] | < 0.001 |
| Birth year | 0.987 [0.98, 1.0] | 0.006 |
During the follow-up period (1.1.1998 — 31.12.2019), 1787 out of 8355 males with H7_OPTNERVE died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTNERVE.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.211% | 0.338% |
| 5 | 0.888% | 2.093% |
| 10 | 2.284% | 4.916% |
| 15 | 4.457% | 9.159% |
| 20 | 7.639% | 15.306% |
Relationships between endpoints
↥Index endpoint: H7_OPTNERVE – Disorders of optic nerve and visual pathways
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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