optic papillitis: Swelling of the optic disk, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause optic atrophy and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
826 |
4. Check minimum number of eventsNone |
826 |
5. Include endpointsNone |
826 |
6. Filter based on genotype QC (FinnGen only) |
826 |
Control definitions (FinnGen only)
- Control exclude
- H7_OPTNERVE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H47
- Name in latin
- Oedema papillae non specificatum
Similar endpoints
↥List of similar endpoints to
Papilloedema, unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5484 | 3197 | 2258 |
| Only index persons | 4991 | 2970 | 2021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.06 |
| Only index persons | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 42.25 | 38.70 | 47.19 |
| Only index persons | 41.63 | 37.90 | 47.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 826 | 521 | 305 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.13 |
| Median age at first event (years) | 46.81 | 41.22 | 56.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 723
- Matched controls
- 7231
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.1
ICD-10 Finland
Papilloedema, unspecified
+∞
323.0
695
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
646.0
161.6
154
*
S01EC01
ATC
acetazolamide; systemic
41.4
125.1
157
48
XCK00
NOMESCO Finland
Perimetry
16.4
118.2
201
166
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
109.2
102
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.0
95.3
209
283
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.6
91.1
280
631
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
11.6
86.9
172
189
TAB00
NOMESCO Finland
Lumbar puncture
14.3
86.1
153
133
H47.3
ICD-10 Finland
Other disorders of optic disc
783.8
73.5
71
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
18.5
73.3
116
74
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.1
72.7
179
282
H46
ICD-10 Finland
Optic neuritis
+∞
67.8
64
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.5
61.6
179
350
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.0
58.0
179
376
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.5
55.8
100
85
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
22.1
55.0
81
41
H47.2
ICD-10 Finland
Optic atrophy
+∞
45.3
43
*
CS494
NOMESCO Finland
Other visual field testing
14.2
37.2
64
49
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.7
33.1
123
304
R51.80
ICD-10 Finland
Headache
3.4
33.1
187
670
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.8
32.6
61
56
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
14.0
32.5
56
43
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
38.4
31.8
40
11
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
27.8
27.3
37
14
H53.4
ICD-10 Finland
Visual field defects
11.6
26.7
50
46
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
47.7
26.7
32
7
AA1AD
NOMESCO Finland
CT of head and brain
2.8
26.5
203
880
H53.1
ICD-10 Finland
Subjective visual disturbances
4.8
24.8
87
201
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.4
21.3
51
73
37791
ICD-8 Finland
Other diseases of retina and optic nerve, Papilloedema. Stasis papillae
+∞
20.9
20
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
11.4
19.9
37
34
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
13.4
18.1
31
24
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
19.2
17.4
26
14
H02AB06
ATC
prednisolone; systemic
2.0
17.4
338
2206
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
10.7
17.3
33
32
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
92.2
16.6
18
*
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
48.7
16.1
19
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
61.4
15.8
18
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
15.4
86
294
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
15.1
290
1854
L04AX01
ATC
azathioprine; systemic
4.4
14.8
54
130
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
76.6
13.6
15
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
13.2
13.5
23
18
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
28.9
13.0
17
6
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.5
12.8
60
181
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
12.8
61
187
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
12.5
84
326
A02BC02
ATC
pantoprazole; systemic
1.8
12.4
434
3317
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
27.2
12.1
16
6
H02AB09
ATC
hydrocortisone; systemic
7.0
12.0
29
43
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
12.8
11.7
20
16
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
30.6
11.7
15
5
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
11.6
158
867
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.1
11.3
35
72
C08CA01
ATC
amlodipine; oral
1.9
11.2
201
1225
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.2
11.1
41
101
L04AA06
ATC
mycophenolic acid; systemic
5.9
11.0
30
53
G91.1
ICD-10 Finland
Obstructive hydrocephalus
21.8
10.7
15
7
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
7.0
10.5
25
37
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
111.6
10.4
11
*
C03CA01
ATC
furosemide; systemic
2.0
10.4
160
917
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
10.4
10
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
33.0
10.4
13
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
10.3
593
5120
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
9.8
10.3
20
21
A02BC01
ATC
omeprazole; systemic
1.9
10.3
188
1149
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.7
10.0
28
51
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
6.9
10.0
24
36
PAW37
NOMESCO Finland
Biopsy of temporal artery
17.0
9.9
15
9
E66.8
ICD-10 Finland
Other obesity
3.1
9.8
53
179
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
9.8
315
2285
ZXA10
NOMESCO Finland
Bilateral
2.0
9.8
132
719
N03AX11
ATC
topiramate; oral
4.7
9.7
32
71
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
55.7
9.7
11
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
9.4
269
1878
J01FF01
ATC
clindamycin; systemic
1.8
9.3
186
1164
G47.3
ICD-10 Finland
Sleep apnoea
1.9
9.3
141
804
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
9.1
102
514
D33.30
ICD-10 Finland
Acoustic neuroma
18.9
9.0
13
7
B03XA02
ATC
darbepoetin alfa; parenteral
6.4
8.8
22
35
H34.8
ICD-10 Finland
Other retinal vascular occlusions
5.5
8.8
25
47
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
14.2
8.7
14
10
WX110
NOMESCO Finland
Local anesthesy
1.6
8.6
494
4118
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
10.2
8.6
16
16
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.4
187
1209
3770A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Papilloedema
+∞
8.3
8
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
14.7
8.2
13
9
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
8.1
247
1741
R01AD09
ATC
mometasone; nasal
1.6
7.9
308
2308
XCD20
NOMESCO Finland
Photoangiography of eye
5.5
7.9
22
41
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
3.4
7.9
37
114
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
7.7
71
328
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.6
105
575
N18.8
ICD-10 Finland
Other chronic renal failure
4.4
7.6
26
61
E23.06
ICD-10 Finland
Empty sella
80.9
7.4
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
6.1
7.4
19
32
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
13.5
7.4
12
9
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
13.5
7.4
12
9
H02AB02
ATC
dexamethasone; systemic
2.3
7.3
68
315
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
8.5
7.3
15
18
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.0
7.3
22
45
G44.2
ICD-10 Finland
Tension-type headache
1.9
7.2
102
563
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
6.7
7.1
17
26
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
8.9
7.1
14
16
B05DA
ATC
Isotonic solutions
8.9
7.1
14
16
H57.1
ICD-10 Finland
Ocular pain
3.5
7.0
31
92
SPAT1153
SPAT
Removal of sutures
1.6
6.9
202
1403
127
Kela drug reimbursment
Transplant complication
4.6
6.8
22
49
137
Kela drug reimbursment
Uraemia requiring dialysis
7.3
6.7
15
21
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
6.5
6.7
16
25
R01AD08
ATC
fluticasone; nasal
1.6
6.7
189
1295
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.6
245
1796
B05DB
ATC
Hypertonic solutions
8.8
6.6
13
15
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
10.1
6.5
12
12
SPAT1263
SPAT
Sampling
1.5
6.5
296
2276
G03.9
ICD-10 Finland
Meningitis, unspecified
14.5
6.4
10
7
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
6.4
85
461
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
6.4
39
146
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
6.6
6.4
15
23
XCW12
NOMESCO Finland
Assessment of colour vision
+∞
6.3
6
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.8
6.2
120
737
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.1
6.1
22
55
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
6.1
47
201
ZX120
NOMESCO Finland
Intravenous
2.1
6.0
70
357
H36.01
ICD-10 Finland
Diabetic maculopathy
5.2
6.0
17
33
N03AX12
ATC
gabapentin; oral
1.9
6.0
93
530
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
5.6
6.0
16
29
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
4.6
6.0
19
42
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
193
173
14.25
191.22
1.4
1.4
468.7
442.7
mg/l
0.12
186
164
177
159
13.90
174.53
1.4
1.4
3.6
3.7
mmol/l
0.17
164
150
162
161
12.27
148.78
1.5
1.3
22.2
11.7
e6/l
0.38
137
127
162
161
12.27
148.78
1.6
1.4
288.6
774.0
e6/l
0.32
139
131
93
62
16.78
107.47
1.2
1.1
55.9
40.4
mg/l
0.37
73
50
91
59
17.21
106.67
1.2
1.0
352.5
222.5
mg/l
0.54
74
52
86
57
16.72
99.55
1.2
1.0
—
—
—
0
0
80
47
18.74
98.32
1.3
1.0
1.1
1.1
u/l
0.05
41
23
96
82
13.12
96.14
1.1
1.1
—
—
—
0
0
94
78
13.47
95.82
1.1
1.1
—
—
—
0
0
87
70
13.77
90.25
1.1
1.1
—
—
—
0
0
130
259
5.77
63.86
2.9
2.2
38.6
38.8
u/l
0.04
117
235
173
470
4.39
58.51
2.7
2.3
27.6
18.8
au/ml
—
5
26
54
60
9.56
44.68
1.3
1.2
—
—
—
0
0
572
3691
2.79
40.52
7.3
5.0
6.6
6.5
mmol/l
0.40
543
3394
80
163
5.33
37.83
2.7
2.2
10.5
11.9
mg/l
0.77
75
152
439
2569
2.51
36.78
7.3
4.8
35.9
36.2
g/l
0.47
414
2394
483
2955
2.53
36.72
11.3
6.9
1.2
1.2
mmol/l
2.11
415
2507
26
11
24.37
36.14
1.2
1.2
—
—
—
0
0
218
932
2.82
34.57
2.7
2.3
29.9
29.7
s
0.12
210
910
167
633
3.05
32.85
2.5
2.0
376.4
376.3
nmol/l
0.00
161
581
441
2688
2.37
32.37
10.1
6.5
1.2
1.2
mmol/l
2.26
409
2439
327
1755
2.43
32.01
2.4
2.1
156.3
284.4
u/l
1.32
312
1659
31
29
11.07
28.81
1.5
1.4
—
—
—
0
0
22
11
20.52
28.50
1.1
1.0
17.2
5.6
mg/g
0.65
22
11
29
29
10.33
25.73
1.1
1.0
—
—
—
0
0
136
556
2.73
22.76
6.4
4.6
0.9
1.8
mmol/l
1.83
98
448
171
795
2.45
21.90
10.6
6.1
1.1
1.1
mmol/l
0.22
163
743
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
31
42
7.63
21.75
1.2
1.1
—
—
—
0
0
124
507
2.70
20.65
8.7
9.5
121.7
120.7
g/l
0.19
119
490
85
284
3.22
20.35
10.6
13.6
—
—
—
0
0
138
605
2.54
19.92
8.6
9.4
0.5
1.0
mmol/l
0.54
91
484
528
3874
2.01
19.84
12.2
8.7
4.4
4.0
e9/l
2.52
476
3387
24
27
9.12
19.50
2.1
2.7
425.3
722.0
u/ml
1.21
24
27
347
2218
1.97
19.39
3.4
3.4
40.6
32.6
ng/l
0.16
224
1373
136
611
2.47
18.57
8.8
9.3
4.9
5.1
kpa
1.44
128
586
136
611
2.47
18.57
8.7
9.3
13.7
12.5
kpa
1.54
128
589
22
24
9.39
18.27
1.1
1.3
—
—
—
0
0
18
15
12.25
17.85
1.1
1.1
—
—
—
0
0
18
15
12.25
17.85
1.1
1.1
—
—
—
0
0
27
40
6.94
17.50
1.1
1.1
—
—
—
0
0
119
519
2.51
17.25
15.0
7.5
9.0
8.6
mmol/l
0.35
114
496
614
4872
2.01
16.96
11.7
7.1
79.9
77.4
u/l
0.40
594
4562
103
424
2.63
16.81
1.8
2.8
65.5
66.9
g/l
0.93
97
388
183
970
2.14
16.78
5.6
3.7
0.8
0.8
mmol/l
0.32
176
911
86
325
2.84
16.55
6.4
8.4
22.8
24.6
mmol/l
2.60
77
304
607
4825
1.97
16.30
5.7
3.9
12.8
10.8
mm/h
2.73
573
4454
446
3221
1.84
16.13
8.7
6.1
10.8
11.9
umol/l
0.65
430
3046
386
2680
1.83
15.77
3.2
2.3
72.4
74.2
nmol/l
0.67
360
2422
17
16
10.83
15.58
1.2
1.3
—
—
—
0
0
99
417
2.56
15.38
5.2
5.4
5.0
5.1
kpa
0.96
92
389
96
399
2.59
15.33
5.2
5.5
0.5
1.5
mmol/l
1.40
59
294
17
17
10.19
14.96
1.2
1.1
—
—
—
0
0
17
17
10.19
14.96
1.2
1.2
—
—
—
0
0
308
2047
1.80
14.14
3.6
3.1
2.3
2.4
mmol/l
0.53
278
1808
175
972
2.02
13.92
2.1
1.9
—
—
—
0
0
760
6711
2.66
13.75
24.5
14.0
139.6
139.6
mmol/l
0.14
750
6513
294
1943
1.80
13.65
4.9
2.5
55.0
56.3
u/l
0.23
278
1803
760
6728
2.62
13.36
24.7
14.1
3.9
4.0
mmol/l
0.40
749
6515
105
485
2.33
13.30
5.8
4.0
5.1
4.7
kpa
1.29
105
470
97
436
2.39
13.07
5.1
4.2
113.4
80.4
ng/l
1.07
82
395
126
639
2.15
12.71
4.5
4.1
251.0
240.0
u/l
0.27
120
610
14
14
10.16
12.26
1.1
1.3
—
—
—
0
0
241
1555
1.78
11.83
3.5
2.6
2780.7
5573.4
umol/l
0.71
219
1364
135
724
2.03
11.70
7.7
6.2
—
—
—
0
0
248
1622
1.76
11.58
4.7
3.3
1607.9
263.8
mg/l
1.55
174
1069
432
3279
1.67
11.56
4.9
3.3
0.0
0.0
estimate
0.00
95
639
232
1495
1.77
11.37
2.1
1.8
1.9
1.1
mg/l
0.52
176
1111
256
1705
1.73
11.13
5.9
4.1
21.9
10.0
mg/mmol
1.45
180
1109
18
28
6.55
11.13
1.1
1.0
—
—
—
0
0
39
118
3.42
10.93
1.1
1.1
—
—
—
0
0
45
150
3.12
10.81
3.4
3.6
21.5
24.5
mmol/l
4.03
39
132
543
4414
1.67
10.78
6.0
4.1
1417.4
2994.8
e6/l
—
7
65
12
12
10.13
10.46
7.2
5.5
—
—
—
0
0
753
6774
2.26
10.40
22.2
12.5
20.6
22.3
mg/l
0.71
648
5268
427
3294
1.61
10.23
6.5
4.6
0.0
0.0
estimate
0.50
95
644
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
45
155
3.01
10.23
5.3
4.4
0.4
0.3
u/ml
0.47
20
80
431
3336
1.61
10.16
5.0
3.4
0.0
0.0
estimate
0.50
97
621
94
465
2.15
10.04
7.9
3.4
1.2
1.2
mmol/l
1.67
85
401
71
312
2.40
10.04
9.0
4.7
23.4
23.9
mmol/l
0.69
64
289
16
25
6.51
9.84
1.2
1.2
—
—
—
0
0
23
51
4.61
9.82
1.1
1.2
—
—
—
0
0
160
961
1.82
9.78
3.8
2.3
12.5
13.6
umol/l
1.13
151
888
40
132
3.13
9.78
11.2
7.1
1585.3
206.1
iu/ml
—
8
16
666
5787
1.78
9.65
7.0
5.2
40.0
39.0
mmol/mol
1.63
638
5422
35
110
3.28
9.27
2.7
2.3
16.9
15.8
%
0.77
25
51
249
1716
1.65
9.23
5.0
3.0
0.3
0.4
e6/l
0.95
199
1280
140
821
1.85
9.21
4.1
2.3
22.7
23.6
%
0.34
114
709
244
1676
1.65
9.15
2.6
2.1
3.2
3.0
mg/l
0.94
221
1447
22
50
4.49
9.12
3.1
2.6
18.9
11.2
%
0.54
13
34
51
203
2.61
8.89
2.2
1.6
1.4
0.0
iu/ml
—
8
38
147
888
1.80
8.76
4.0
2.3
2.3
2.4
g/l
1.05
140
824
306
2240
1.58
8.75
5.8
3.1
—
—
—
0
0
270
1919
1.60
8.75
5.2
3.2
7.4
8.0
mmol/l
1.40
238
1630
61
267
2.39
8.71
2.1
1.4
10.1
9.4
u/l
0.17
51
215
612
5250
1.64
8.69
4.9
3.9
14.7
14.6
pmol/l
0.23
569
4797
120
682
1.89
8.69
2.0
1.8
—
—
—
0
0
223
1515
1.65
8.66
3.5
3.2
1561.6
1122.9
ng/l
0.86
188
1260
10
10
10.11
8.66
1.2
1.3
—
—
—
0
0
251
1764
1.61
8.47
5.5
3.5
0.0
0.0
estimate
0.88
90
633
21
49
4.37
8.44
3.3
2.6
—
—
—
0
0
20
46
4.43
8.18
2.0
3.0
—
—
—
0
0
37
130
2.93
8.16
3.6
3.8
56.4
56.2
%
0.03
37
130
194
1296
1.65
7.97
4.8
2.5
4.4
6.9
e6/l
1.76
173
1136
400
3173
1.51
7.62
5.2
4.0
—
—
—
0
0
100
560
1.89
7.55
1.3
1.2
130.0
145.8
iu/ml
0.16
38
229
51
220
2.40
7.54
1.6
1.7
—
—
—
0
0
43
171
2.60
7.53
2.5
2.8
—
—
—
0
0
95
524
1.92
7.51
11.1
8.5
1.3
1.3
mmol/l
0.04
95
506
35
125
2.88
7.51
3.4
3.5
3.8
4.3
e9/l
0.72
35
125
115
676
1.81
7.45
2.1
1.8
—
—
—
0
0
86
471
1.92
6.94
2.7
2.3
5701.6
4029.3
u/l
0.28
27
199
183
1248
1.60
6.82
1.7
1.7
45333759.0
24905726.0
pmol/l
0.18
150
1056
47
206
2.36
6.73
1.2
1.1
—
—
—
0
0
35
134
2.68
6.63
9.8
1.9
1.1
0.8
nmol/l
1.05
30
108
157
1039
1.63
6.60
3.6
2.7
1.2
0.9
e6/l
0.50
88
581
77
415
1.94
6.52
1.9
1.6
—
—
—
0
0
25
80
3.19
6.48
1.9
1.7
—
—
—
0
0
328
2558
1.47
6.48
5.2
3.4
—
—
—
0
0
51
238
2.22
6.33
1.9
1.9
—
—
—
0
0
37
150
2.54
6.27
1.4
1.2
—
—
—
0
0
762
7104
1.94
6.17
15.8
9.4
26.7
26.0
u/l
0.41
747
6866
686
6220
1.61
6.08
5.7
4.6
1.9
2.0
mu/l
0.49
649
5753
46
211
2.25
5.96
1.6
1.9
1.0
2.6
ug/l
0.62
38
190
36
149
2.48
5.86
2.1
1.6
—
—
—
0
0
64
337
1.97
5.81
1.6
1.6
—
—
—
0
0
57
288
2.05
5.80
6.5
6.0
24.3
24.7
mmol/l
0.40
51
277
37
157
2.42
5.72
2.2
1.5
125.5
105.0
u/ml
—
8
31
159
1091
1.57
5.70
4.0
3.6
179.1
320.7
ng/l
0.99
112
777
30
115
2.67
5.70
1.5
1.5
—
—
—
0
0
50
242
2.13
5.69
2.3
2.4
1.3
1.4
g/l
0.21
43
213
29
110
2.70
5.62
1.2
1.1
1.0
72.6
iu/ml
—
6
28
39
171
2.34
5.61
1.2
2.4
11.2
10.4
g/l
0.30
26
150
33
134
2.52
5.60
1.8
1.4
8.4
19.7
u/l
3.81
27
115
286
2227
1.43
5.49
4.4
3.2
29.8
31.0
u/l
0.23
272
2121
688
6287
1.56
5.41
5.3
4.0
6.0
5.8
mmol/l
1.83
638
5780
151
1040
1.55
5.30
2.7
2.7
2.4
2.4
mmol/l
0.09
138
908
394
3261
1.40
5.28
3.8
2.8
140.0
101.2
ug/l
2.05
372
3034
11
22
5.05
5.27
2.2
1.5
—
—
—
0
0
37
164
2.32
5.21
2.4
1.6
—
—
—
0
0
149
1029
1.55
5.16
2.0
1.7
1255.1
1154.3
nmol/l
0.85
122
787
29
116
2.55
5.09
1.5
1.2
5.6
4.6
u/ml
0.14
18
52
34
147
2.37
5.07
1.4
4.0
26.9
33.1
mg/l
0.62
25
114
34
147
2.37
5.07
1.5
4.0
171.3
97.4
mg/l
0.22
24
115
40
186
2.21
5.05
1.2
2.3
3.7
3.7
g/l
0.07
23
137
40
186
2.21
5.05
1.2
2.3
8.0
7.2
g/l
0.92
23
145
40
186
2.21
5.05
1.2
2.3
—
—
—
0
0
9
9
10.09
5.03
1.1
1.3
—
—
—
0
0
14
36
3.94
5.00
1.1
1.3
—
—
—
0
0
302
2413
1.40
4.88
2.2
1.9
100.1
95.6
pmol/l
0.81
183
1271
143
994
1.53
4.80
4.1
2.8
3.1
2.8
e6/l
0.19
74
543
8
7
11.52
4.79
1.1
1.6
—
—
—
0
0
75
446
1.75
4.69
2.1
2.6
3.3
7.0
ug/l
3.69
69
398
36
167
2.21
4.59
2.2
1.6
—
—
—
0
0
7
5
14.10
4.58
1.0
1.2
—
—
—
0
0
13
34
3.87
4.55
1.2
1.1
1355.8
1401.7
miu/ml
0.04
13
34
37
175
2.17
4.51
1.2
2.4
3.5
3.1
g/l
0.90
23
141
15
44
3.45
4.48
1.1
1.1
1.1
1.1
ratio
—
5
19
96
619
1.62
4.45
4.2
3.0
—
—
—
0
0
37
176
2.15
4.45
1.6
1.3
185.6
239.0
u/ml
0.99
30
103
18
60
3.04
4.42
2.8
1.8
615.0
715.8
e6/l
0.22
11
22
41
205
2.05
4.34
1.4
1.3
—
—
—
0
0
8
9
8.96
4.28
1.3
1.3
—
—
—
0
0
30
133
2.30
4.27
1.2
1.7
—
—
—
0
0
17
56
3.08
4.26
1.8
1.4
—
—
—
0
0
8
10
8.06
4.06
1.4
1.7
—
—
—
0
0
8
10
8.06
4.06
1.1
1.1
—
—
—
0
0
666
6142
1.44
4.06
19.1
11.1
85.0
87.0
ml/min/173m2
1.21
564
4938
37
184
2.06
3.99
1.6
1.3
—
—
—
0
0
64
382
1.73
3.98
1.7
1.4
19.3
22.1
iu/l
0.29
53
318
63
375
1.74
3.95
1.6
1.4
—
—
—
0
0
20
76
2.67
3.92
2.4
1.5
—
—
—
0
0
42
221
1.95
3.89
3.3
2.9
181.4
176.0
%
0.16
42
210
7
8
8.81
3.78
1.3
1.0
—
—
—
0
0
7
8
8.81
3.78
1.3
1.0
—
—
—
0
0
183
1399
1.40
3.70
1.8
1.5
20.1
20.5
nmol/l
0.14
158
1187
70
437
1.66
3.70
2.5
3.5
4.5
4.6
pmol/l
0.27
63
388
26
116
2.28
3.67
1.5
1.2
2.4
4.9
u/ml
0.60
13
43
14
45
3.15
3.66
1.7
1.5
—
—
—
0
0
190
1470
1.38
3.57
4.9
3.5
1.0
1.0
kg/l
0.19
23
200
510
4550
1.32
3.56
4.2
3.1
46.9
42.7
u/l
0.54
491
4299
8
13
6.20
3.50
1.3
1.2
—
—
—
0
0
6
6
10.06
3.50
1.2
1.5
—
—
—
0
0
694
6501
1.42
3.40
5.3
4.4
2.7
2.8
mmol/l
0.92
658
6043
73
473
1.60
3.35
1.4
1.2
190.3
227.7
u/ml
0.19
67
436
682
6374
1.40
3.35
4.8
3.9
1.4
1.5
mmol/l
8.51
644
5936
11
32
3.47
3.34
1.4
5.1
45.6
146.5
umol/l
—
5
21
204
1614
1.35
3.31
3.3
2.2
—
—
—
0
0
71
460
1.59
3.26
2.2
2.2
9.6
12.5
nmol/l
1.97
65
413
18
72
2.53
3.23
1.7
1.8
—
—
—
0
0
12
38
3.19
3.22
1.9
1.7
—
—
—
0
0
22
97
2.30
3.22
2.2
1.4
—
—
—
0
0
7
11
6.41
3.19
3.1
1.6
—
—
—
0
0
24
111
2.20
3.15
1.9
1.6
—
—
—
0
0
103
733
1.46
3.09
5.2
3.0
4.8
8.5
umol/l
4.28
90
621
40
226
1.81
3.04
3.0
2.1
—
—
—
0
0
20
87
2.33
3.02
1.3
1.3
—
—
—
0
0
21
94
2.27
2.98
1.0
1.1
27.5
18.3
u/l
0.27
21
80
657
6138
1.34
2.95
4.4
3.6
1.4
1.3
mmol/l
3.33
621
5696
27
135
2.03
2.93
1.2
1.1
—
12.3
—
0
10
682
6410
1.37
2.93
4.9
4.0
4.5
4.7
mmol/l
3.15
644
5997
26
129
2.05
2.88
1.1
1.2
—
1.0
—
0
8
23
109
2.14
2.87
1.1
1.1
—
—
—
0
0
19
83
2.32
2.86
1.1
1.2
—
—
—
0
0
19
83
2.32
2.86
2.1
1.5
—
—
—
0
0
24
116
2.10
2.85
2.6
1.6
—
—
—
0
0
71
476
1.54
2.84
2.9
2.4
64.3
72.9
ml/min/173m2
0.72
27
192
5
6
8.37
2.75
1.2
1.2
—
—
—
0
0
20
92
2.20
2.69
5.0
3.1
0.8
1.1
%
0.51
20
74
37
214
1.76
2.64
1.3
1.2
—
—
—
0
0
627
5852
1.30
2.61
25.6
15.2
13.8
13.5
%
4.92
618
5743
26
135
1.96
2.58
1.2
1.2
—
—
—
0
0
10
33
3.06
2.53
1.0
1.9
—
—
—
0
0
10
33
3.06
2.53
1.0
1.9
—
—
—
0
0
6
12
5.03
2.40
3.0
2.7
—
—
—
0
0
5
8
6.28
2.37
7.0
4.1
6.7
9.2
mmol/l
—
5
8
36
214
1.71
2.36
1.3
1.2
—
—
—
0
0
17
78
2.20
2.32
1.2
1.6
—
—
—
0
0
16
72
2.25
2.28
1.1
1.1
—
—
—
0
0
58
392
1.52
2.28
2.4
3.0
95.5
167.0
ng/l
2.47
50
354
785
7624
1.60
2.27
31.6
18.6
133.7
135.2
g/l
2.16
776
7521
27
150
1.83
2.22
1.2
2.4
37.4
38.2
g/l
0.18
22
132
5
9
5.58
2.21
1.0
1.2
—
—
—
0
0
208
1738
1.26
2.19
1.3
1.3
3.2
1.9
u/ml
0.44
60
475
9
30
3.02
2.15
1.1
1.3
—
—
—
0
0
9
30
3.02
2.15
1.1
1.3
—
—
—
0
0
11
43
2.58
2.10
1.3
1.2
—
—
—
0
0
19
96
2.00
2.06
1.2
1.6
—
—
—
0
0
80
593
1.39
1.97
6.0
2.4
34.4
33.7
u/l
0.07
70
492
26
151
1.75
1.89
3.1
2.4
380.2
92.9
ug/min
0.61
18
87
12
52
2.33
1.88
1.6
1.2
1.0
1.4
nmol/l
0.95
12
45
8
28
2.87
1.86
1.0
1.5
—
—
—
0
0
18
93
1.96
1.86
4.8
4.2
86.0
347.1
u/ml
0.50
18
88
30
184
1.65
1.81
1.2
1.2
—
20.0
—
0
8
86
658
1.34
1.76
22.7
19.7
1.0
1.2
inr
3.56
13
97
48
333
1.47
1.72
6.1
2.7
0.1
0.2
e6/l
0.11
48
321
5
13
3.86
1.71
1.0
1.2
—
—
—
0
0
139
1140
1.26
1.71
1.4
1.3
13.3
32.0
iu/ml
5.92
31
359
28
172
1.65
1.69
1.5
1.4
274.5
312.4
ug/g
0.33
13
95
6
19
3.17
1.66
1.3
1.0
—
—
—
0
0
8
31
2.60
1.66
1.3
1.5
—
—
—
0
0
21
120
1.77
1.63
2.4
1.4
—
—
—
0
0
670
6415
1.24
1.60
21.8
13.5
38.8
39.9
%
2.08
471
4939
189
1619
1.22
1.56
5.2
4.8
9.5
2.5
ug/l
0.64
167
1457
15
78
1.94
1.55
1.1
1.1
96.1
96.0
%
0.01
15
71
8
33
2.44
1.54
1.0
1.3
13.5
12.5
u/l
—
8
33
7
27
2.61
1.51
1.0
1.5
—
—
—
0
0
9
37
2.45
1.48
3.1
1.2
—
—
—
0
0
72
925
0.76
1.47
1.7
1.7
1.4
1.4
%
0.03
64
832
50
672
0.73
1.39
1.4
1.6
—
—
—
0
0
13
68
1.93
1.34
1.8
1.7
33.8
33.3
pg
0.30
13
68
17
98
1.75
1.31
1.3
1.1
—
—
—
0
0
9
44
2.06
1.27
1.1
1.5
0.9
1.0
g/l
—
9
44
11
56
1.98
1.22
1.3
1.1
—
—
—
0
0
10
49
2.05
1.22
1.0
1.2
—
95.1
—
0
7
19
116
1.65
1.22
1.2
1.1
—
—
—
0
0
27
388
0.69
1.13
1.4
1.5
—
—
—
0
0
7
32
2.20
1.08
6.1
1.9
27.1
27.3
umol/l
—
7
32
89
738
1.23
1.04
4.9
4.0
30.3
31.5
%
0.55
69
510
25
354
0.70
0.99
1.2
1.4
—
—
—
0
0
66
533
1.26
0.98
4.6
4.4
148.6
36.2
ug/l
0.37
51
436
0
30
0.00
0.97
0.0
1.3
—
—
—
0
0
10
54
1.86
0.97
2.9
2.4
—
—
—
0
0
0
31
0.00
0.96
0.0
1.2
—
12.1
—
0
31
149
1308
1.17
0.96
4.7
4.2
22.7
21.0
%
0.69
78
604
189
1691
1.15
0.95
1.8
1.7
1.4
1.4
mmol/l
0.20
163
1446
22
150
1.48
0.93
1.1
1.3
—
—
—
0
0
6
27
2.23
0.93
1.0
1.3
—
—
—
0
0
6
27
2.23
0.93
1.0
1.3
—
—
—
0
0
46
358
1.30
0.92
1.7
1.7
—
—
—
0
0
57
458
1.26
0.90
1.4
1.4
—
—
—
0
0
26
355
0.72
0.86
1.3
1.4
—
—
—
0
0
26
355
0.72
0.86
1.3
1.4
—
—
—
0
0
26
355
0.72
0.86
1.3
1.4
—
—
—
0
0
6
33
1.82
0.79
3.2
1.8
—
—
—
0
0
6
33
1.82
0.79
3.2
1.8
—
—
—
0
0
6
33
1.82
0.79
3.2
1.8
—
—
—
0
0
6
33
1.82
0.79
3.2
1.8
—
—
—
0
0
21
292
0.71
0.79
1.6
1.9
—
—
—
0
0
20
140
1.44
0.77
2.2
3.9
20.9
26.4
mg/l
0.38
14
93
5
25
2.01
0.72
3.4
1.9
—
—
—
0
0
5
25
2.01
0.72
3.4
1.9
—
—
—
0
0
18
252
0.71
0.71
1.8
1.7
—
—
—
0
0
5
26
1.93
0.70
3.4
1.9
—
—
—
0
0
123
1378
0.87
0.69
2.3
2.3
—
—
—
0
0
35
440
0.79
0.68
1.1
1.0
—
—
—
0
0
10
155
0.64
0.66
1.5
1.2
—
—
—
0
0
35
277
1.28
0.66
1.6
1.4
—
—
—
0
0
27
207
1.31
0.64
1.6
1.7
36.5
41.7
nmol/l
0.72
27
199
56
662
0.83
0.63
1.5
1.5
—
—
—
0
0
5
30
1.67
0.61
4.2
2.4
—
—
—
0
0
9
137
0.65
0.61
1.4
1.3
—
—
—
0
0
0
21
0.00
0.60
0.0
1.4
—
—
—
0
0
522
5049
1.09
0.59
3.4
3.5
—
—
—
0
0
9
63
1.43
0.52
2.4
1.7
—
—
—
0
0
9
63
1.43
0.52
2.4
1.7
—
—
—
0
0
9
63
1.43
0.52
2.4
1.7
—
—
—
0
0
12
86
1.40
0.44
1.5
1.3
—
—
—
0
0
11
78
1.42
0.43
1.1
1.1
1.4
1.4
g/l
0.68
11
72
8
57
1.41
0.42
1.1
1.5
—
—
—
0
0
8
58
1.38
0.41
1.0
1.1
—
—
—
0
0
8
58
1.38
0.41
1.0
1.1
—
—
—
0
0
8
59
1.36
0.41
1.0
1.1
—
—
—
0
0
8
59
1.36
0.41
1.0
1.1
—
—
—
0
0
8
59
1.36
0.41
1.0
1.1
—
—
—
0
0
21
168
1.26
0.40
1.1
1.1
1.8
1.5
u/ml
—
7
70
12
90
1.34
0.36
1.2
1.4
—
—
—
0
0
12
91
1.32
0.34
1.2
1.4
—
—
—
0
0
12
91
1.32
0.34
1.2
1.4
—
—
—
0
0
12
91
1.32
0.34
1.2
1.4
—
—
—
0
0
10
74
1.36
0.32
1.4
2.5
—
21.9
—
0
19
12
92
1.31
0.32
1.2
1.4
—
—
—
0
0
12
92
1.31
0.32
1.2
1.4
—
—
—
0
0
7
55
1.28
0.30
5.0
3.7
—
—
—
0
0
7
56
1.25
0.29
1.3
1.6
—
—
—
0
0
13
162
0.80
0.28
1.6
1.6
—
—
—
0
0
120
1130
1.07
0.27
1.3
1.2
3.5
11.9
u/ml
2.36
41
453
119
1260
0.94
0.26
2.1
2.1
—
—
—
0
0
27
236
1.15
0.24
1.4
1.5
—
—
—
0
0
160
1673
0.95
0.24
1.9
1.6
—
—
—
0
0
19
221
0.86
0.22
1.0
1.1
—
7.6
—
0
28
72
671
1.08
0.22
1.7
1.9
—
—
—
0
0
23
200
1.15
0.22
1.9
1.8
2.3
6.2
iu/l
—
5
69
5
41
1.22
0.22
9.6
3.1
—
—
—
0
0
35
315
1.12
0.21
1.8
1.7
8.6
2.9
mg/l
0.63
28
222
15
126
1.19
0.21
1.3
1.3
—
—
—
0
0
15
126
1.19
0.21
1.3
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
17
145
1.18
0.20
1.0
1.2
—
—
—
0
0
25
282
0.88
0.20
1.9
1.7
—
—
—
0
0
28
250
1.12
0.20
1.5
1.5
—
—
—
0
0
6
50
1.20
0.19
4.3
1.7
—
—
—
0
0
6
50
1.20
0.19
1.8
1.3
—
—
—
0
0
36
327
1.11
0.19
1.4
1.3
51.1
255.4
miu/ml
12.64
13
160
23
259
0.88
0.19
1.4
1.4
—
—
—
0
0
7
61
1.15
0.17
2.3
1.7
—
—
—
0
0
7
61
1.15
0.17
1.1
1.9
—
—
—
0
0
28
309
0.90
0.17
1.5
1.6
—
—
—
0
0
8
69
1.16
0.16
1.1
1.1
—
—
—
0
0
139
1342
1.04
0.15
1.3
1.5
—
—
—
0
0
16
179
0.89
0.12
1.8
1.4
184.9
128.7
pmol/l
0.17
16
174
41
433
0.94
0.10
1.4
1.4
—
—
—
0
0
86
835
1.03
0.08
1.9
2.0
—
—
—
0
0
16
146
1.10
0.08
1.1
1.3
—
—
—
0
0
6
73
0.82
0.07
1.3
1.5
—
—
—
0
0
23
216
1.07
0.07
2.7
3.4
104.9
1797.0
u/ml
1.28
17
191
10
107
0.93
0.02
3.5
5.6
362.2
377.8
umol/l
—
10
95
94
947
0.99
0.01
3.3
2.9
0.9
0.8
ug/l
0.43
66
608
13
132
0.98
0.00
1.4
1.8
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
6
65
0.92
0.00
1.5
1.1
—
—
—
0
0
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0
5
50
1.00
0.00
1.6
1.5
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
3.2
—
71.4
—
0
9
0
5
0.00
0.00
0.0
1.0
—
3.5
—
0
5
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
0.00
0.0
1.8
—
—
—
0
0
6
61
0.98
0.00
1.2
1.0
—
—
—
0
0
9
93
0.97
0.00
1.4
2.7
4.1
54.7
u/ml
—
9
83
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_PAPILLOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PAPILLOEDEMA | 1.805 [1.5, 2.18] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.933 |
During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 2534 females with H7_PAPILLOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PAPILLOEDEMA | 1.735 [1.45, 2.08] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1743 males with H7_PAPILLOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_PAPILLOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.222% | 0.329% |
| 5 | 1.191% | 2.395% |
| 10 | 2.856% | 5.595% |
| 15 | 5.566% | 10.492% |
| 20 | 10.02% | 17.3% |
Relationships between endpoints
↥Index endpoint: H7_PAPILLOEDEMA – Papilloedema, unspecified
GWS hits: 2
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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