optic papillitis: Swelling of the optic disk, usually in association with increased intracranial pressure, characterized by hyperemia, blurring of the disk margins, microhemorrhages, blind spot enlargement, and engorgement of retinal veins. Chronic papilledema may cause optic atrophy and visual loss. (Miller et al., Clinical Neuro-Ophthalmology, 4th ed, p175)
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
826 |
4. Check minimum number of eventsNone |
826 |
5. Include endpointsNone |
826 |
6. Filter based on genotype QC (FinnGen only) |
826 |
Control definitions (FinnGen only)
- Control exclude
- H7_OPTNERVE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H47
- Name in latin
- Oedema papillae non specificatum
Similar endpoints
↥List of similar endpoints to
Papilloedema, unspecified
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5484 | 3197 | 2258 |
| Only index persons | 4991 | 2970 | 2021 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.08 | 0.09 | 0.06 |
| Only index persons | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 42.25 | 38.70 | 47.19 |
| Only index persons | 41.63 | 37.90 | 47.11 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 826 | 521 | 305 |
| Unadjusted period prevalence (%) | 0.16 | 0.18 | 0.13 |
| Median age at first event (years) | 46.81 | 41.22 | 56.36 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 723
- Matched controls
- 7231
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.1
ICD-10 Finland
Papilloedema, unspecified
+∞
323.0
695
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
646.0
161.6
154
*
S01EC01
ATC
acetazolamide; systemic
41.4
125.1
157
48
XCK00
NOMESCO Finland
Perimetry
16.4
118.2
201
166
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
109.2
102
*
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
10.0
95.3
209
283
Z01.0
ICD-10 Finland
Examination of eyes and vision
6.6
91.1
280
631
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
11.6
86.9
172
189
TAB00
NOMESCO Finland
Lumbar puncture
14.3
86.1
153
133
H47.3
ICD-10 Finland
Other disorders of optic disc
783.8
73.5
71
*
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
18.5
73.3
116
74
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
8.1
72.7
179
282
H46
ICD-10 Finland
Optic neuritis
+∞
67.8
64
*
XCK10
NOMESCO Finland
Photography of fundus of eye
6.5
61.6
179
350
XCW99
NOMESCO Finland
Other investigative procedure of eye
6.0
58.0
179
376
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
13.5
55.8
100
85
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
22.1
55.0
81
41
H47.2
ICD-10 Finland
Optic atrophy
+∞
45.3
43
*
CS494
NOMESCO Finland
Other visual field testing
14.2
37.2
64
49
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.7
33.1
123
304
R51.80
ICD-10 Finland
Headache
3.4
33.1
187
670
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.8
32.6
61
56
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
14.0
32.5
56
43
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
38.4
31.8
40
11
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
27.8
27.3
37
14
H53.4
ICD-10 Finland
Visual field defects
11.6
26.7
50
46
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
47.7
26.7
32
7
AA1AD
NOMESCO Finland
CT of head and brain
2.8
26.5
203
880
H53.1
ICD-10 Finland
Subjective visual disturbances
4.8
24.8
87
201
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
7.4
21.3
51
73
37791
ICD-8 Finland
Other diseases of retina and optic nerve, Papilloedema. Stasis papillae
+∞
20.9
20
*
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
11.4
19.9
37
34
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
13.4
18.1
31
24
AAF05
NOMESCO Finland
Ventriculoperitoneal shunt
19.2
17.4
26
14
H02AB06
ATC
prednisolone; systemic
2.0
17.4
338
2206
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
10.7
17.3
33
32
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
92.2
16.6
18
*
I67.6
ICD-10 Finland
Nonpyogenic thrombosis of intracranial venous system
48.7
16.1
19
*
AAF20
NOMESCO Finland
Revision of shunt of ventricle of brain
61.4
15.8
18
*
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
3.2
15.4
86
294
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
15.1
290
1854
L04AX01
ATC
azathioprine; systemic
4.4
14.8
54
130
AAF25
NOMESCO Finland
Removal of shunt of ventricle of brain
76.6
13.6
15
*
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
13.2
13.5
23
18
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
28.9
13.0
17
6
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.5
12.8
60
181
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.5
12.8
61
187
Z3229
NOMESCO Finland
Other healthcare associate professional
3.0
12.7
77
280
E66.01
ICD-10 Finland
Obesity due to excess calories
2.8
12.5
84
326
A02BC02
ATC
pantoprazole; systemic
1.8
12.4
434
3317
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
27.2
12.1
16
6
H02AB09
ATC
hydrocortisone; systemic
7.0
12.0
29
43
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
12.8
11.7
20
16
G91.9
ICD-10 Finland
Hydrocephalus, unspecified
30.6
11.7
15
5
TPH04
NOMESCO Finland
Cathetrisation of vein
2.1
11.6
158
867
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.1
11.3
35
72
C08CA01
ATC
amlodipine; oral
1.9
11.2
201
1225
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
4.2
11.1
41
101
L04AA06
ATC
mycophenolic acid; systemic
5.9
11.0
30
53
G91.1
ICD-10 Finland
Obstructive hydrocephalus
21.8
10.7
15
7
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
7.0
10.5
25
37
AAA27
NOMESCO Finland
Insertion of intracerebral pressure monitoring device
111.6
10.4
11
*
C03CA01
ATC
furosemide; systemic
2.0
10.4
160
917
AAF10
NOMESCO Finland
Lumboperitoneal shunt
+∞
10.4
10
*
G91.0
ICD-10 Finland
Communicating hydrocephalus
33.0
10.4
13
*
N02BE01
ATC
paracetamol; systemic, rectal
1.9
10.3
593
5120
AAB10
NOMESCO Finland
Partial excision of intracranial lesion
9.8
10.3
20
21
A02BC01
ATC
omeprazole; systemic
1.9
10.3
188
1149
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
5.7
10.0
28
51
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
6.9
10.0
24
36
PAW37
NOMESCO Finland
Biopsy of temporal artery
17.0
9.9
15
9
E66.8
ICD-10 Finland
Other obesity
3.1
9.8
53
179
I10
ICD-10 Finland
Essential (primary) hypertension
1.7
9.8
315
2285
ZXA10
NOMESCO Finland
Bilateral
2.0
9.8
132
719
N03AX11
ATC
topiramate; oral
4.7
9.7
32
71
T85.0
ICD-10 Finland
Mechanical complication of ventricular intracranial (communicating) shunt
55.7
9.7
11
*
N02AX02
ATC
tramadol; systemic, rectal
1.7
9.4
269
1878
J01FF01
ATC
clindamycin; systemic
1.8
9.3
186
1164
G47.3
ICD-10 Finland
Sleep apnoea
1.9
9.3
141
804
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.1
9.1
102
514
D33.30
ICD-10 Finland
Acoustic neuroma
18.9
9.0
13
7
B03XA02
ATC
darbepoetin alfa; parenteral
6.4
8.8
22
35
H34.8
ICD-10 Finland
Other retinal vascular occlusions
5.5
8.8
25
47
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
14.2
8.7
14
10
WX110
NOMESCO Finland
Local anesthesy
1.6
8.6
494
4118
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
10.2
8.6
16
16
ZXD05
NOMESCO Finland
Urgent procedure
1.7
8.5
219
1478
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.7
8.4
187
1209
3770A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Papilloedema
+∞
8.3
8
*
H49.0
ICD-10 Finland
Third [oculomotor] nerve palsy
14.7
8.2
13
9
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
8.1
247
1741
Z3231
NOMESCO Finland
Registered nurse
1.7
8.0
191
1259
R01AD09
ATC
mometasone; nasal
1.6
7.9
308
2308
XCD20
NOMESCO Finland
Photoangiography of eye
5.5
7.9
22
41
CKD05
NOMESCO Finland
Puncture of vitreous body with injection of medication
3.4
7.9
37
114
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
7.7
71
328
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.0
7.6
105
575
N18.8
ICD-10 Finland
Other chronic renal failure
4.4
7.6
26
61
E23.06
ICD-10 Finland
Empty sella
80.9
7.4
8
*
Z94.0
ICD-10 Finland
Kidney transplant status
6.1
7.4
19
32
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
13.5
7.4
12
9
H35.0
ICD-10 Finland
Background retinopathy and retinal vascular changes
13.5
7.4
12
9
H02AB02
ATC
dexamethasone; systemic
2.3
7.3
68
315
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
8.5
7.3
15
18
AA1CD
NOMESCO Finland
Very extensive CT of head and brain
5.0
7.3
22
45
G44.2
ICD-10 Finland
Tension-type headache
1.9
7.2
102
563
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
6.7
7.1
17
26
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
8.9
7.1
14
16
B05DA
ATC
Isotonic solutions
8.9
7.1
14
16
H57.1
ICD-10 Finland
Ocular pain
3.5
7.0
31
92
SPAT1153
SPAT
Removal of sutures
1.6
6.9
202
1403
127
Kela drug reimbursment
Transplant complication
4.6
6.8
22
49
137
Kela drug reimbursment
Uraemia requiring dialysis
7.3
6.7
15
21
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
6.5
6.7
16
25
R01AD08
ATC
fluticasone; nasal
1.6
6.7
189
1295
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.6
6.6
245
1796
B05DB
ATC
Hypertonic solutions
8.8
6.6
13
15
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
10.1
6.5
12
12
SPAT1263
SPAT
Sampling
1.5
6.5
296
2276
G03.9
ICD-10 Finland
Meningitis, unspecified
14.5
6.4
10
7
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
2.0
6.4
85
461
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.8
6.4
39
146
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
6.6
6.4
15
23
XCW12
NOMESCO Finland
Assessment of colour vision
+∞
6.3
6
*
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
1.8
6.2
120
737
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
4.1
6.1
22
55
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.4
6.1
47
201
ZX120
NOMESCO Finland
Intravenous
2.1
6.0
70
357
H36.01
ICD-10 Finland
Diabetic maculopathy
5.2
6.0
17
33
N03AX12
ATC
gabapentin; oral
1.9
6.0
93
530
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
5.6
6.0
16
29
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
4.6
6.0
19
42
Mortality – FinRegistry
↥Association
Association between endpoint H7_PAPILLOEDEMA and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PAPILLOEDEMA | 1.805 [1.5, 2.18] | < 0.001 |
| Birth year | 1.0 [0.99, 1.01] | 0.933 |
During the follow-up period (1.1.1998 — 31.12.2019), 302 out of 2534 females with H7_PAPILLOEDEMA died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_PAPILLOEDEMA | 1.735 [1.45, 2.08] | < 0.001 |
| Birth year | 0.99 [0.98, 1.0] | 0.026 |
During the follow-up period (1.1.1998 — 31.12.2019), 318 out of 1743 males with H7_PAPILLOEDEMA died.
Mortality risk
Mortality risk for people of age
years, who have H7_PAPILLOEDEMA.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.222% | 0.329% |
| 5 | 1.191% | 2.395% |
| 10 | 2.856% | 5.595% |
| 15 | 5.566% | 10.492% |
| 20 | 10.02% | 17.3% |
Relationships between endpoints
↥Index endpoint: H7_PAPILLOEDEMA – Papilloedema, unspecified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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