Disorders of optic nerve, not elsewhere classified

H7_OPTNERVNAS

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H47.0
  • Hospital discharge: ICD-9 3774
  • Hospital discharge: ICD-8 37799
  • Cause of death: ICD-10 H47.0
  • Cause of death: ICD-9 3774
  • Cause of death: ICD-8 37799

2 out of 7 registries used, show all original rules.

760

4. Check minimum number of events

None

760

5. Include endpoints

None

760

6. Filter based on genotype QC (FinnGen only)

739

Control definitions (FinnGen only)

Control exclude
H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy
4
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H47
Name in latin
Morbositates nervi optici non alibi classificatae

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 5048 2489 2516
Only index persons 4410 2212 2198
Unadjusted period prevalence (%)
Whole population 0.07 0.07 0.07
Only index persons 0.08 0.08 0.08
Median age at first event (years)
Whole population 62.97 63.63 62.38
Only index persons 62.67 63.16 62.18

-FinnGen-

Key figures

All Female Male
Number of individuals 739 367 372
Unadjusted period prevalence (%) 0.15 0.13 0.17
Median age at first event (years) 62.68 59.70 65.62

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
760
Matched controls
7600
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
307.7
714
*
XCK00
NOMESCO Finland
Perimetry
15.0
237.3
245
233
H47.1
ICD-10 Finland
Papilloedema, unspecified
1578.5
139.1
131
*
H46
ICD-10 Finland
Optic neuritis
+∞
122.3
114
*
H53.4
ICD-10 Finland
Visual field defects
16.7
101.4
88
59
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
52.2
100.4
58
12
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
74.0
268
865
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
8.7
72.6
98
127
XCK10
NOMESCO Finland
Photography of fundus of eye
5.1
71.5
181
441
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.0
69.1
180
448
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.0
67.4
75
75
H47.2
ICD-10 Finland
Optic atrophy
+∞
66.7
63
*
G35
ICD-10 Finland
Multiple sclerosis
23.8
64.7
47
21
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.1
63.2
122
232
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.6
63.1
179
475
CS494
NOMESCO Finland
Other visual field testing
10.6
62.5
71
73
H53.1
ICD-10 Finland
Subjective visual disturbances
5.7
60.0
123
247
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
23.9
59.3
43
19
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
4.9
53.7
133
314
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
9.3
52.8
66
77
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
13.7
40.2
38
29
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
39.9
38
*
37799
ICD-8 Finland
Other diseases of retina and optic nerve, Unspecified
+∞
39.9
38
*
TAB00
NOMESCO Finland
Lumbar puncture
5.2
36.4
79
165
Z3229
NOMESCO Finland
Other healthcare associate professional
3.5
29.8
114
364
PAW37
NOMESCO Finland
Biopsy of temporal artery
34.3
28.0
36
11
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.2
27.9
60
124
109
Kela drug reimbursment
Multiple sclerosis
27.8
23.7
32
12
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
33.4
22.5
29
9
AA1AD
NOMESCO Finland
CT of head and brain
2.2
22.4
266
1489
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
30.1
22.0
29
10
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
82.6
21.8
24
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
5.5
20.8
41
78
XCD20
NOMESCO Finland
Photoangiography of eye
6.9
20.5
32
48
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
6.8
20.2
32
49
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.0
20.1
98
359
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.3
17.9
156
760
Z3231
NOMESCO Finland
Registered nurse
2.0
17.4
244
1430
H34.1
ICD-10 Finland
Central retinal artery occlusion
21.5
17.4
25
12
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.9
17.1
399
2779
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
41.1
16.4
20
5
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
4.9
16.0
36
77
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
13.3
15.8
27
21
N86
ICPC
Multiple sclerosis
36.8
14.5
18
5
A10AB05
ATC
insulin aspart; parenteral
2.7
14.0
79
312
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.2
13.6
122
596
S01EC01
ATC
acetazolamide; systemic
4.4
13.2
33
77
R51.80
ICD-10 Finland
Headache
2.2
13.0
129
657
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.0
12.9
57
197
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
11.8
12.9
23
20
L04AX07
ATC
dimethyl fumarate; oral
71.1
12.6
14
*
H02AB06
ATC
prednisolone; systemic
1.7
12.3
379
2771
H34.8
ICD-10 Finland
Other retinal vascular occlusions
4.4
12.3
31
73
L03AB07
ATC
interferon beta-1a; parenteral
38.2
12.2
15
*
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.3
12.1
47
150
G93.2
ICD-10 Finland
Benign intracranial hypertension
35.6
11.3
14
*
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
20.4
11.2
16
8
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
11.0
148
840
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.7
10.9
279
1922
H54.4
ICD-10 Finland
Blindness, monocular
21.8
10.7
15
7
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
111.5
10.4
11
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
111.5
10.4
11
*
3774A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic nerve
+∞
10.4
10
*
A10AC01
ATC
insulin (human); parenteral
2.4
10.4
74
327
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
8.4
10.4
22
27
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
4.2
10.2
27
66
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.6
10.0
59
238
ZXA10
NOMESCO Finland
Bilateral
1.8
10.0
160
958
CKC12
NOMESCO Finland
Photocoagulation of retina
3.0
10.0
44
152
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
9.7
240
1627
F05
ICPC
Visual disturbance other
3.4
9.7
35
107
A11CC03
ATC
alfacalcidol; systemic
3.9
9.6
28
74
WX892
NOMESCO Finland
Monitored bed care
2.3
9.1
69
314
WX408
NOMESCO Finland
General anesthesy, balanced
1.7
9.0
204
1347
L03AX13
ATC
glatiramer acetate; parenteral
18.9
9.0
13
7
E10.3
ICD-10 Finland
Type 1 diabetes mellitus, With ophthalmic complications
3.9
8.8
26
69
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.0
8.7
107
586
M31.6
ICD-10 Finland
Other giant cell arteritis
20.3
8.5
12
6
H53.8
ICD-10 Finland
Other visual disturbances
4.7
8.4
19
41
H47.7
ICD-10 Finland
Disorder of visual pathways, unspecified
+∞
8.3
8
*
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
7.2
8.3
19
27
R20.2
ICD-10 Finland
Paraesthesia of skin
2.5
8.3
54
229
B01AC04
ATC
clopidogrel; oral
1.8
8.3
146
897
WX872
NOMESCO Finland
Intensive care
2.5
8.2
50
205
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
7.7
8.2
18
24
AA4CG
NOMESCO Finland
Extensive MRI examination of sella turcica with high intensity magnet
10.2
8.1
15
15
N03AX14
ATC
levetiracetam; systemic
3.6
8.0
26
74
S01ED51
ATC
timolol, combinations; ophthalmic
2.2
8.0
71
344
H3603, E103,
ICD-10 Finland
13.2
7.9
13
10
A10AE04
ATC
insulin glargine; parenteral
2.0
7.9
84
437
A02BC02
ATC
pantoprazole; systemic
1.6
7.8
503
4215
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
2.4
7.8
54
236
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
1.8
7.8
126
754
H54.0
ICD-10 Finland
Blindness, binocular
45.4
7.7
9
*
H40.11
ICD-10 Finland
Low pressure glaucoma
3.7
7.6
24
67
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
3.6
7.6
25
72
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
7.5
171
1125
ZXD05
NOMESCO Finland
Urgent procedure
1.6
7.5
224
1579
N03AX16
ATC
[U] pregabalin
1.6
7.4
180
1204
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
2.1
7.4
67
328
C08CA01
ATC
amlodipine; oral
1.5
7.3
298
2249
H40.0
ICD-10 Finland
Glaucoma suspect
2.1
7.3
70
351
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
4.6
7.2
17
38
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
3.5
7.2
24
70
H43.1
ICD-10 Finland
Vitreous haemorrhage
3.3
7.2
26
80
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
20.2
7.1
10
5
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
7.1
315
2419
XF400
NOMESCO Finland
ECG with 12 standard connections
1.7
7.0
127
784
C07AB07
ATC
bisoprolol; oral
1.5
6.9
382
3060
H3603, E113,
ICD-10 Finland
6.8
6.8
16
24
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
1.9
6.8
83
453
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
2.5
6.8
42
174
ZXE20
NOMESCO Finland
More than three and less than five hours
1.8
6.8
113
681
H28.0*E10.3
ICD-10 Finland
Other specified diabetes mellitus - Diabetic cataract
40.4
6.8
8
*
XCW12
NOMESCO Finland
Assessment of colour vision
40.4
6.8
8
*
H57.1
ICD-10 Finland
Ocular pain
2.8
6.7
33
122
M05BA04
ATC
alendronic acid; oral
2.0
6.6
70
363
I67.1
ICD-10 Finland
Cerebral aneurysm, nonruptured
3.6
6.6
21
59
C10AA07
ATC
rosuvastatin; oral
1.5
6.5
236
1729
A28
ICPC
Limited function/disability NOS
1.7
6.5
137
882
C03CA01
ATC
furosemide; systemic
1.5
6.5
243
1792
TK800
NOMESCO Finland
Hemodialysis
3.4
6.5
23
70
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.7
6.4
125
786
XCH00
NOMESCO Finland
Eye pressure measurement
2.4
6.4
45
198
N02AX02
ATC
tramadol; systemic, rectal
1.5
6.4
318
2482
N02BE01
ATC
paracetamol; systemic, rectal
1.7
6.4
658
5982
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic
1.5
6.3
262
1969
ZXC40
NOMESCO Finland
Use of ultrasound
8.2
6.3
13
16
N05CF01
ATC
zopiclone; oral
1.5
6.3
239
1764
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
9.4
6.3
12
13
C10AA05
ATC
atorvastatin; oral
1.5
6.3
321
2517
H47
ICD-10 Finland
Other disorders of optic [2nd] nerve and visual pathways
+∞
6.3
6
*
34099
ICD-8 Finland
Multiple sclerosis
+∞
6.3
6
*
R42
ICD-10 Finland
Dizziness and giddiness
1.6
6.2
170
1166
H02AB09
ATC
hydrocortisone; systemic
3.4
6.2
22
67
205
Kela drug reimbursment
Chronic hypertension
1.5
6.1
210
1515
E23.00
ICD-10 Finland
Panhypopituitarism
10.1
6.0
11
11
E10.9
ICD-10 Finland
Type 1 diabetes mellitus, Without complications
2.7
6.0
32
123

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
34
41
8.63
26.30
1.3
1.1
33.97
45.14
mg/l
0.62
34
36
467
3192
2.20
24.00
10.1
7.1
1.21
1.21
mmol/l
0.91
402
2711
51
109
4.94
22.74
1.3
1.2
—
—
—
0
0
318
1964
2.06
20.25
2.5
2.1
213.27
242.64
u/l
0.22
300
1844
26
32
8.38
19.73
1.9
1.3
—
—
—
0
0
424
2925
2.02
19.62
8.6
6.3
1.21
1.21
mmol/l
0.98
395
2658
112
485
2.54
16.55
3.3
2.8
9.35
10.78
g/l
4.05
107
444
438
3169
1.90
16.42
8.6
5.7
2.03
1.91
e9/l
0.23
388
2816
431
3103
1.90
16.39
8.7
5.6
0.60
0.59
e9/l
0.23
382
2692
581
4635
2.08
16.17
6.0
4.1
14.06
12.74
mm/h
1.21
540
4235
124
569
2.41
16.16
10.7
7.4
11.49
10.28
mmol/l
0.98
118
542
496
3755
1.92
15.98
6.2
5.0
6.87
6.74
mmol/l
0.55
468
3525
430
3111
1.88
15.92
8.7
5.6
0.04
0.04
e9/l
0.24
381
2706
480
3609
1.90
15.63
11.7
9.0
4.37
4.12
e9/l
1.30
430
3167
407
2912
1.86
15.43
9.4
6.1
—
—
—
0
0
296
1929
1.88
14.99
5.9
4.1
7.40
7.40
ph
0.19
57
371
159
836
2.14
14.89
9.2
5.6
1.08
1.03
mmol/l
1.49
153
771
435
3207
1.83
14.67
8.9
5.9
0.22
0.19
e9/l
1.71
388
2829
27
50
5.56
14.09
1.2
1.1
—
—
—
0
0
387
2790
1.79
13.72
6.4
4.8
35.00
35.24
g/l
0.33
362
2603
391
2831
1.78
13.62
9.0
5.8
0.67
0.66
%
0.07
375
2643
45
133
3.53
13.07
1.4
1.2
3.09
11.69
e6/l
0.92
35
106
45
133
3.53
13.07
1.4
1.3
22.18
947.21
e6/l
0.60
38
109
399
2931
1.76
13.01
9.5
6.1
8.68
8.73
%
0.11
381
2746
396
2919
1.74
12.61
9.2
5.8
2.95
2.86
%
0.27
380
2728
403
2986
1.74
12.59
9.3
6.0
26.03
27.21
%
1.15
385
2800
26
52
5.14
12.49
1.2
1.2
—
—
—
0
0
272
1807
1.79
12.42
5.6
4.3
—
—
—
0
0
324
2270
1.74
12.25
5.2
3.8
57.09
117.06
e6/l
0.95
234
1631
177
1034
1.93
12.15
4.0
3.4
0.80
0.82
mmol/l
0.83
168
969
146
801
2.02
12.00
1.4
1.3
335.17
476.09
titre
0.99
29
174
411
3095
1.71
11.83
22.5
15.9
1.41
1.29
inr
0.97
95
896
394
2941
1.71
11.64
9.0
5.7
58.68
57.65
%
0.88
376
2760
585
4881
1.86
11.61
10.2
7.6
82.26
78.50
u/l
0.77
548
4568
345
2493
1.70
11.44
5.0
3.8
28.94
52.73
ng/l
1.07
261
1834
267
1800
1.75
11.38
3.7
3.2
0.29
0.51
e6/l
1.55
209
1368
336
2433
1.68
10.89
4.7
3.6
5.82
5.94
ph
0.21
11
149
284
1968
1.71
10.85
4.2
3.3
98.32
93.84
e6/l
0.03
222
1523
170
1015
1.87
10.79
2.6
2.0
31.20
29.69
s
0.88
163
986
432
3356
1.67
10.56
7.3
6.3
12.16
11.39
umol/l
0.37
416
3187
110
569
2.09
10.54
2.6
3.1
64.84
66.58
g/l
1.55
101
517
116
614
2.05
10.45
6.5
3.6
1.54
2.07
mmol/l
0.73
102
505
116
615
2.05
10.40
6.6
3.6
5.76
5.83
kpa
0.25
116
598
83
391
2.26
10.05
2.6
1.7
1.35
1.57
g/l
0.40
77
358
100
517
2.08
9.57
5.2
2.8
4.70
4.39
kpa
0.86
100
500
341
2539
1.62
9.52
2.7
2.2
80.30
77.56
nmol/l
0.92
319
2245
132
756
1.90
9.44
3.5
2.6
1.75
1.78
%
0.15
123
676
251
1736
1.67
9.37
3.7
3.1
—
—
—
0
0
685
6151
2.15
9.28
24.1
15.2
24.78
24.75
mg/l
0.01
578
4904
504
4168
1.62
8.80
6.5
4.5
15.50
3698.60
e6/l
1.84
12
67
388
3020
1.58
8.74
5.2
3.8
0.01
0.00
estimate
0.41
75
617
703
6405
2.30
8.72
27.0
17.7
139.55
139.66
mmol/l
0.59
689
6226
518
4318
1.63
8.70
6.1
4.4
—
—
—
0
0
92
479
2.05
8.63
2.5
2.7
—
—
—
0
0
209
1404
1.67
8.61
4.9
3.8
—
—
—
0
0
148
903
1.79
8.60
4.2
2.4
21.61
22.55
%
0.37
127
772
12
6
20.29
8.49
1.2
1.0
6.94
7.19
mg/g
—
12
6
703
6420
2.27
8.41
27.4
17.9
3.99
3.99
mmol/l
0.32
688
6231
64
294
2.29
8.22
7.2
3.8
24.00
24.15
mmol/l
0.15
64
287
385
3021
1.56
8.17
6.8
5.1
0.00
0.00
estimate
-0.00
70
571
161
1022
1.73
8.13
4.1
2.5
12.01
12.95
umol/l
0.99
152
955
172
1113
1.70
8.10
3.3
2.8
1.46
1.00
e6/l
0.66
96
647
340
2599
1.56
8.08
3.7
2.8
135.57
138.53
ug/l
0.11
310
2377
23
60
3.92
8.02
1.6
1.3
—
—
—
0
0
202
1371
1.64
7.91
3.3
2.6
4.35
4.89
e6/l
0.44
185
1233
101
563
1.92
7.79
3.3
2.7
68.59
69.15
e9/l
0.07
76
448
387
3068
1.53
7.65
5.1
3.8
0.00
0.01
estimate
0.50
68
554
697
6395
2.08
7.40
21.4
14.4
—
—
—
0
0
222
1564
1.59
7.39
9.0
6.7
—
—
—
0
0
149
950
1.71
7.35
4.2
2.4
2.24
2.33
g/l
1.34
141
884
32
113
2.91
7.03
1.5
1.4
—
—
—
0
0
125
768
1.75
7.02
7.2
8.1
12.69
11.90
kpa
0.87
119
737
125
768
1.75
7.02
7.2
8.1
4.97
5.11
kpa
0.91
119
736
289
2181
1.52
7.01
3.9
3.5
2.35
2.35
mmol/l
0.08
265
1905
124
763
1.75
6.92
7.1
8.2
1.27
1.25
mmol/l
0.02
97
611
105
615
1.82
6.92
1.9
1.5
—
—
—
0
0
470
3936
1.51
6.83
4.0
3.1
54.35
51.28
u/l
0.31
439
3638
17
40
4.32
6.78
1.5
1.8
44.07
38.46
%
0.69
17
40
232
1680
1.55
6.76
3.6
2.8
2144.40
7943.29
umol/l
1.99
200
1442
93
531
1.86
6.65
10.4
8.8
—
—
—
0
0
350
2771
1.49
6.64
13.1
9.6
0.00
0.00
e9/l
0.47
276
2273
137
877
1.69
6.62
1.9
1.8
—
—
—
0
0
263
1967
1.52
6.57
4.0
3.3
1222.50
249.27
mg/l
1.22
183
1276
272
2049
1.51
6.56
3.9
3.2
6.89
7.42
mmol/l
1.15
240
1704
53
248
2.22
6.54
2.3
2.8
8.89
10.56
g/l
1.86
44
222
119
737
1.73
6.48
1.8
1.6
—
—
—
0
0
61
305
2.09
6.38
2.3
2.1
1.44
1.53
g/l
0.28
52
271
121
757
1.71
6.35
2.2
1.7
—
—
—
0
0
28
98
2.93
6.26
1.4
1.2
—
—
—
0
0
49
227
2.24
6.21
2.6
2.1
542.67
599.45
ug/l
0.06
44
211
704
6546
2.02
6.19
14.7
10.7
27.64
25.85
u/l
0.96
682
6287
335
2657
1.47
6.15
2.2
2.0
93.00
94.52
pmol/l
0.22
183
1353
193
1367
1.55
6.13
1.8
1.7
1.77
1.22
mg/l
0.96
152
1047
38
158
2.48
6.13
1.3
1.3
—
—
—
0
0
264
2008
1.48
5.95
2.9
2.5
62.55
98.05
u/l
0.42
243
1865
261
1982
1.48
5.93
3.8
3.2
—
—
—
0
0
222
1637
1.50
5.81
2.4
2.2
3.17
3.10
mg/l
0.19
200
1398
270
2079
1.46
5.66
4.5
3.9
21.57
8.98
mg/mmol
1.61
186
1325
65
349
1.94
5.61
8.1
11.3
—
—
—
0
0
22
72
3.12
5.53
2.6
2.7
1.07
1.49
g/24h
0.34
11
36
181
1291
1.53
5.51
1.9
1.7
1158.18
1188.41
nmol/l
0.22
150
967
152
1043
1.57
5.50
3.9
3.0
3.64
1.99
e6/l
0.74
77
585
149
1021
1.57
5.42
1.3
1.3
41.03
40.36
iu/ml
0.02
40
326
258
1983
1.46
5.41
4.6
3.2
44.58
32.18
u/l
0.64
247
1882
185
1331
1.52
5.39
3.6
3.0
552.90
546.28
mosm/kgh2o
0.16
165
1142
28
107
2.68
5.37
1.2
1.3
323.26
290.49
u/ml
0.23
23
59
532
4675
1.46
5.30
4.5
3.9
15.09
14.90
pmol/l
1.00
493
4181
70
393
1.86
5.29
1.5
1.4
—
—
—
0
0
108
696
1.64
5.05
7.2
8.5
96.43
95.46
%
1.53
103
669
590
5310
1.50
5.04
26.8
18.0
15.57
15.11
%
1.00
585
5225
54
283
1.98
5.01
6.2
6.5
0.91
0.90
%
0.05
49
266
112
731
1.62
4.98
3.4
2.7
9.62
8.86
umol/l
0.09
93
638
88
540
1.71
4.94
4.9
4.1
1.84
1.00
%
0.91
45
201
54
285
1.96
4.92
6.2
6.4
1.40
1.57
%
1.38
49
269
45
224
2.07
4.81
3.8
3.9
135.67
88.79
mg/l
0.22
39
181
45
224
2.07
4.81
3.8
3.9
35.80
45.61
mg/l
0.31
40
181
303
2450
1.39
4.63
2.2
2.1
—
—
—
0
0
99
638
1.63
4.63
8.2
9.0
117.66
121.11
g/l
0.79
94
623
79
480
1.72
4.60
5.1
4.2
0.17
0.75
%
0.45
36
140
628
5758
1.52
4.59
7.2
6.1
41.96
40.36
mmol/mol
3.18
589
5301
43
215
2.06
4.55
2.5
3.0
37.76
37.83
g/l
0.02
34
190
137
957
1.53
4.53
2.7
2.0
—
—
—
0
0
256
2029
1.39
4.34
3.5
3.1
2442.97
1468.70
ng/l
1.38
218
1741
618
5669
1.48
4.29
5.6
4.7
1.96
1.95
mu/l
0.09
570
5097
13
29
4.54
4.26
1.5
2.1
101.00
89.58
umol/l
—
8
19
90
579
1.63
4.24
2.6
2.1
358.79
373.54
nmol/l
0.29
82
533
254
2022
1.38
4.17
3.0
2.4
—
—
—
0
0
59
340
1.80
4.14
8.2
10.2
24.58
24.47
mmol/l
0.09
59
332
20
74
2.75
4.11
1.8
2.3
—
—
—
0
0
171
1273
1.44
4.10
4.6
4.0
208.91
391.96
ng/l
1.20
139
1024
90
584
1.61
4.10
2.9
2.5
5.06
6.96
ug/l
1.09
79
520
160
1178
1.45
4.07
1.7
1.5
2.28
2.57
g/l
1.53
104
691
80
505
1.65
4.06
4.9
4.2
0.24
0.13
%
0.37
37
165
80
507
1.65
4.00
6.8
3.6
129.70
85.05
ng/l
1.58
71
445
714
6795
1.84
3.99
34.4
22.3
247.18
245.51
e9/l
0.26
703
6610
10
18
5.61
3.98
1.1
1.0
1879.40
1676.78
miu/ml
—
10
18
77
484
1.66
3.98
4.4
4.1
1.76
0.62
%
0.53
36
170
714
6796
1.84
3.97
34.6
22.4
39.54
39.97
%
0.95
664
6304
714
6797
1.83
3.95
34.3
22.2
91.60
91.28
fl
1.07
707
6681
714
6797
1.83
3.95
34.3
22.1
30.39
30.37
pg
0.05
707
6680
714
6797
1.83
3.95
34.4
22.3
7.12
6.75
e9/l
2.47
701
6590
30
138
2.22
3.94
6.5
2.7
—
—
—
0
0
714
6798
1.83
3.94
34.4
22.3
4.39
4.47
e12/l
3.26
702
6590
20
76
2.68
3.92
1.4
1.3
—
—
—
0
0
714
6800
1.83
3.90
34.6
22.4
132.31
134.86
g/l
4.09
707
6682
74
465
1.66
3.83
1.5
1.4
—
—
—
0
0
20
77
2.64
3.83
4.1
4.2
—
—
—
0
0
84
546
1.61
3.80
4.9
3.4
—
—
—
0
0
499
4452
1.35
3.75
4.6
4.0
—
—
—
0
0
82
540
1.58
3.53
4.8
3.7
1.22
1.23
mmol/l
0.32
75
472
72
461
1.62
3.48
4.6
5.6
—
—
—
0
0
344
2929
1.32
3.47
2.9
2.6
—
—
—
0
0
21
88
2.43
3.42
1.2
1.7
0.61
0.76
g/l
0.33
15
68
67
426
1.63
3.33
6.1
3.2
123.10
126.77
g/l
0.53
67
419
25
115
2.21
3.32
2.0
1.6
—
—
—
0
0
31
156
2.03
3.29
2.8
2.8
32.75
32.49
umol/l
0.02
24
137
194
1531
1.36
3.25
2.8
2.3
—
—
—
0
0
13
39
3.37
3.23
2.6
2.7
41.00
40.74
%
—
6
23
67
431
1.61
3.19
7.0
8.2
24.22
24.56
mmol/l
0.30
62
409
198
1572
1.35
3.18
1.7
1.6
21.00
20.52
nmol/l
0.16
172
1328
175
1365
1.37
3.15
6.1
4.1
1.02
1.02
kg/l
0.27
22
197
86
590
1.52
3.10
3.1
2.4
34.54
32.49
u/l
0.20
74
500
38
211
1.84
3.06
5.8
8.2
1.96
1.35
mmol/l
0.65
31
187
624
5837
1.39
2.99
4.7
4.1
1.35
1.28
mmol/l
1.34
577
5278
31
163
1.94
2.94
4.4
4.3
7.41
7.42
ph
0.40
26
141
8
17
4.74
2.92
6.0
4.8
35.69
45.74
%
—
8
17
54
338
1.64
2.88
5.6
3.4
24.77
25.13
mmol/l
0.26
54
331
168
1321
1.35
2.86
1.3
1.2
1.70
1.58
u/ml
0.06
43
333
31
166
1.90
2.80
4.7
4.0
—
—
—
0
0
15
59
2.57
2.80
2.1
1.3
31.76
30.22
u/l
—
8
49
24
117
2.09
2.80
2.0
2.2
1760.54
3533.57
u/l
—
7
39
21
97
2.20
2.79
4.9
2.8
—
—
—
0
0
642
6052
1.39
2.77
5.4
4.8
6.12
6.01
mmol/l
1.22
593
5461
29
153
1.93
2.74
6.5
9.5
12.67
11.40
mmol/l
0.54
24
139
29
153
1.93
2.74
6.5
9.5
104.21
105.28
mmol/l
0.35
24
139
34
191
1.82
2.66
1.1
1.1
—
—
—
0
0
16
67
2.42
2.64
1.8
1.6
—
—
—
0
0
63
421
1.54
2.59
8.7
9.4
0.66
0.68
%
0.23
63
415
63
422
1.54
2.56
8.7
9.3
1.44
1.40
%
0.07
63
416
81
575
1.46
2.50
1.4
1.4
—
—
—
0
0
16
69
2.35
2.49
1.3
1.3
—
—
—
0
0
79
559
1.46
2.48
1.7
1.5
—
—
—
0
0
39
234
1.70
2.47
3.8
3.3
0.52
0.28
g/l
1.08
23
95
16
70
2.31
2.42
2.4
2.8
—
—
—
0
0
63
428
1.51
2.41
5.0
3.6
7.39
7.41
ph
—
8
50
654
6216
1.37
2.40
5.9
5.1
2.54
2.69
mmol/l
4.03
609
5659
129
1001
1.35
2.38
1.3
1.3
9.50
13.20
u/ml
0.28
46
369
14
58
2.44
2.38
1.1
1.2
—
—
—
0
0
22
111
2.01
2.37
1.0
1.5
—
—
—
0
0
25
133
1.91
2.33
4.0
4.6
2.64
2.62
mmol/l
0.01
18
89
642
6093
1.35
2.30
5.2
4.6
4.41
4.58
mmol/l
3.89
599
5589
202
1676
1.28
2.30
6.1
4.1
0.00
0.01
estimate
0.50
68
549
6
13
4.64
2.27
1.0
1.1
—
—
—
0
0
7
18
3.91
2.25
1.0
1.6
—
—
—
0
0
24
128
1.90
2.23
3.6
3.5
—
—
—
0
0
24
128
1.90
2.23
2.8
2.5
16.89
15.98
%
—
10
64
156
1256
1.30
2.23
3.0
3.2
2.45
2.45
mmol/l
0.09
142
1098
5
9
5.58
2.21
1.4
1.4
—
—
—
0
0
11
41
2.71
2.21
1.9
1.8
11.32
10.37
%
0.32
11
41
11
41
2.71
2.21
5.8
2.5
—
—
—
0
0
32
189
1.72
2.17
1.5
1.5
204.20
285.04
ug/g
1.44
15
110
28
159
1.79
2.16
1.8
1.8
—
—
—
0
0
6
14
4.31
2.15
6.2
5.5
—
—
—
0
0
17
81
2.12
2.14
1.4
1.3
—
—
—
0
0
85
630
1.39
2.10
2.4
2.3
0.22
0.21
g/l
0.51
80
593
636
6049
1.32
2.08
5.2
4.5
1.42
1.46
mmol/l
1.74
588
5507
5
10
5.02
2.07
14.6
5.7
5.00
6.67
mmol/l
—
5
10
5
10
5.02
2.07
1.0
1.0
—
—
—
0
0
57
393
1.49
2.07
1.6
1.6
—
—
—
0
0
77
564
1.41
2.04
3.7
3.2
272.04
217.04
ng/l
0.34
68
519
30
178
1.71
2.01
3.6
3.0
—
—
—
0
0
49
334
1.50
1.89
1.7
1.3
—
—
—
0
0
7
22
3.20
1.88
1.7
2.7
—
—
—
0
0
101
785
1.33
1.86
1.7
1.4
—
—
—
0
0
18
93
1.96
1.86
3.4
2.3
—
—
—
0
0
11
46
2.41
1.86
1.1
1.7
—
—
—
0
0
24
137
1.78
1.85
2.1
1.2
19.80
8.95
u/l
0.70
16
106
13
59
2.22
1.85
5.1
2.7
—
—
—
0
0
48
328
1.49
1.84
4.5
2.6
1.15
1.18
%
0.06
48
328
18
94
1.94
1.81
1.7
1.5
—
—
—
0
0
7
23
3.06
1.80
2.3
2.3
—
—
—
0
0
92
710
1.34
1.79
2.0
2.1
130.10
137.33
ug/g
0.09
71
567
38
249
1.55
1.77
1.9
1.9
—
—
—
0
0
6
18
3.35
1.75
1.8
1.8
—
—
—
0
0
63
460
1.40
1.73
2.7
2.1
10.57
12.61
nmol/l
1.20
53
401
8
30
2.68
1.72
1.3
1.0
—
—
—
0
0
47
326
1.47
1.69
5.7
3.6
—
—
—
0
0
19
104
1.85
1.68
2.8
2.8
—
—
—
0
0
17
90
1.91
1.66
1.1
1.1
—
—
—
0
0
52
370
1.44
1.65
1.2
1.2
167.84
133.32
iu/ml
0.26
18
145
26
158
1.67
1.64
1.4
1.2
—
—
—
0
0
21
121
1.76
1.59
3.2
3.4
60.67
58.26
%
0.24
21
121
6
20
3.02
1.58
1.7
1.3
—
—
—
0
0
7
26
2.71
1.58
1.3
1.0
—
—
—
0
0
34
225
1.54
1.54
1.1
1.1
—
—
—
0
0
12
58
2.09
1.49
1.0
1.2
—
—
—
0
0
61
459
1.36
1.43
1.2
1.2
—
—
—
0
0
19
111
1.73
1.40
1.7
1.4
—
—
—
0
0
223
1968
1.19
1.36
5.3
4.0
—
—
—
0
0
81
641
1.30
1.36
6.5
4.5
—
—
—
0
0
17
97
1.77
1.36
2.2
1.4
—
—
—
0
0
9
44
2.06
1.27
1.1
1.1
—
—
—
0
0
48
357
1.37
1.23
1.4
1.2
402.91
264.22
u/ml
0.28
43
326
12
63
1.92
1.23
1.2
1.1
—
—
—
0
0
12
63
1.92
1.23
2.0
2.4
—
—
—
0
0
163
1415
1.19
1.19
1.8
1.7
408.26
16408034.50
pmol/l
1.07
132
1158
87
708
1.26
1.19
1.3
1.3
—
—
—
0
0
23
149
1.56
1.18
1.1
1.1
—
—
—
0
0
22
141
1.58
1.18
2.6
2.1
133.50
127.95
g/l
0.40
14
103
18
110
1.65
1.16
6.8
2.1
65.85
60.42
%
0.65
18
110
15
87
1.74
1.15
1.3
1.1
1.86
8.68
u/ml
—
7
38
20
127
1.59
1.12
1.2
1.1
—
—
—
0
0
8
40
2.01
1.12
1.4
1.2
—
—
—
0
0
12
66
1.83
1.09
1.2
1.2
—
—
—
0
0
16
97
1.66
1.07
1.0
1.1
—
—
—
0
0
10
52
1.94
1.06
2.0
1.8
—
—
—
0
0
19
121
1.58
1.06
1.2
1.3
48.07
61.44
mmol/l
0.57
14
105
20
300
0.66
1.05
1.5
1.4
—
—
—
0
0
5
22
2.28
1.03
3.2
2.6
32900.00
35277.50
ug/l
—
5
22
5
22
2.28
1.03
2.6
1.7
20.40
59.78
ug/l
—
5
22
44
334
1.34
1.03
3.7
4.0
—
—
—
0
0
38
282
1.37
1.02
1.2
1.2
—
—
—
0
0
54
424
1.29
1.00
2.6
3.3
3.97
5.99
e9/l
1.16
44
340
18
115
1.58
1.00
3.0
3.1
4.54
4.42
e9/l
0.07
18
115
50
389
1.31
0.99
1.3
1.3
—
—
—
0
0
14
84
1.68
0.98
3.6
2.0
33.79
32.64
pg
0.86
14
84
5
23
2.18
0.98
1.0
1.5
—
—
—
0
0
7
36
1.95
0.97
1.6
1.8
—
—
—
0
0
45
347
1.32
0.96
2.3
2.4
—
—
—
0
0
18
118
1.54
0.91
1.4
1.6
—
—
—
0
0
184
1652
1.15
0.90
4.6
3.5
—
—
—
0
0
6
29
2.08
0.89
1.0
1.5
1.69
1.60
g/l
—
6
29
10
56
1.80
0.88
1.3
1.1
—
—
—
0
0
6
32
1.88
0.82
1.0
1.2
171.67
147.25
nmol/l
—
6
32
13
81
1.62
0.81
1.2
1.6
—
—
—
0
0
188
1705
1.14
0.79
1.7
1.7
1.44
1.38
mmol/l
0.41
158
1407
11
67
1.65
0.75
1.5
2.3
—
—
—
0
0
5
25
2.01
0.72
34.6
30.1
92.60
115.00
ug/l
—
5
20
7
39
1.80
0.72
1.3
1.5
0.78
1.02
g/l
—
7
39
93
807
1.17
0.72
1.4
1.3
—
—
—
0
0
12
76
1.59
0.72
1.3
1.4
—
—
—
0
0
7
40
1.76
0.71
2.3
3.3
—
—
—
0
0
5
26
1.93
0.70
1.2
1.1
—
—
—
0
0
20
143
1.41
0.70
1.7
1.3
—
—
—
0
0
64
539
1.20
0.70
5.2
3.9
—
—
—
0
0
5
27
1.86
0.68
1.4
1.2
6.06
6.79
mmol/l
—
5
27
20
144
1.40
0.68
1.7
1.3
—
—
—
0
0
20
144
1.40
0.68
1.7
1.3
—
—
—
0
0
19
136
1.41
0.67
1.7
1.3
—
—
—
0
0
5
28
1.79
0.66
1.2
1.1
244.60
184.91
iu/ml
—
5
28
14
95
1.48
0.64
1.4
1.5
23.93
31.37
g/l
—
9
83
17
121
1.41
0.62
2.6
3.1
—
—
—
0
0
10
63
1.60
0.62
1.6
1.5
—
—
—
0
0
250
2339
1.10
0.61
4.8
5.2
2.41
3.15
ug/l
0.82
222
2071
13
88
1.49
0.61
1.5
1.1
—
—
—
0
0
0
20
0.00
0.60
0.0
1.3
—
22.69
—
0
13
8
52
1.54
0.59
1.1
1.3
—
—
—
0
0
11
72
1.54
0.59
1.2
1.2
—
—
—
0
0
25
193
1.31
0.58
4.6
5.1
—
—
—
0
0
48
402
1.21
0.57
3.0
2.9
—
—
—
0
0
36
439
0.81
0.57
1.4
1.4
—
—
—
0
0
20
150
1.34
0.56
1.7
2.5
—
—
—
0
0
32
257
1.26
0.56
3.8
4.2
1.24
1.38
mmol/l
0.35
32
248
15
107
1.41
0.55
5.1
2.9
—
—
—
0
0
6
37
1.63
0.55
1.0
1.3
104.47
177.30
pmol/l
—
6
37
27
213
1.28
0.54
4.0
4.2
3.73
3.93
mmol/l
1.74
27
207
11
74
1.49
0.53
1.2
1.4
35540.00
140487.59
e6/l
—
5
37
6
39
1.54
0.53
2.5
3.4
—
—
—
0
0
23
180
1.29
0.50
2.4
2.4
109.39
97.08
ug/min
0.10
14
105
33
271
1.23
0.49
5.1
4.9
—
—
—
0
0
11
76
1.45
0.48
1.2
1.2
—
75.14
—
0
5
193
2059
0.92
0.47
3.4
3.0
—
—
—
0
0
7
48
1.46
0.47
2.0
1.3
—
—
—
0
0
8
121
0.66
0.45
1.4
1.6
—
—
—
0
0
21
165
1.28
0.45
1.4
1.3
38.97
28.42
iu/l
0.47
16
141
12
86
1.40
0.44
1.2
1.1
—
17.59
—
0
17
0
15
0.00
0.41
0.0
1.0
—
1.50
—
0
9
0
15
0.00
0.41
0.0
1.1
—
0.77
—
0
7
0
17
0.00
0.40
0.0
2.0
—
—
—
0
0
5
36
1.39
0.38
10.8
1.7
8.20
9.27
mmol/l
—
5
36
5
36
1.39
0.38
1.6
1.5
77.20
83.08
umol/l
—
5
36
9
67
1.35
0.38
1.1
1.2
—
—
nmol/l
—
0
0
79
717
1.11
0.37
3.1
4.2
4.12
28.72
ug/l
1.46
60
608
18
143
1.27
0.37
1.8
1.3
—
—
—
0
0
144
1347
1.09
0.37
3.3
3.0
0.77
0.78
ug/l
0.07
99
906
11
81
1.36
0.36
1.3
1.6
56.83
62.75
%
—
6
56
6
47
1.28
0.32
1.0
1.0
325.00
295.70
mg/l
—
6
40
22
186
1.19
0.28
1.5
1.2
—
—
—
0
0
8
65
1.23
0.27
1.4
1.1
—
—
—
0
0
19
225
0.84
0.26
1.8
1.7
—
—
—
0
0
17
141
1.21
0.26
4.8
4.0
14.68
29.32
mg/l
—
9
85
59
643
0.91
0.26
1.7
1.6
—
—
—
0
0
9
75
1.20
0.25
1.1
1.1
—
—
—
0
0
9
76
1.19
0.24
1.1
1.1
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
15.83
—
0
6
0
11
0.00
0.21
0.0
1.0
—
17.67
—
0
11
0
10
0.00
0.21
0.0
1.0
—
10.80
—
0
5
11
89
1.24
0.21
1.0
1.3
—
—
—
0
0
0
13
0.00
0.21
0.0
1.0
—
0.58
—
0
5
0
14
0.00
0.20
0.0
5.4
—
—
—
0
0
6
51
1.18
0.19
1.0
1.1
—
—
—
0
0
6
53
1.13
0.18
1.3
1.2
488.83
385.49
nmol/l
—
6
45
7
63
1.11
0.17
1.6
1.2
—
—
—
0
0
8
70
1.14
0.16
1.1
1.4
—
—
—
0
0
30
276
1.09
0.13
2.4
3.5
42.00
5035.03
u/ml
0.78
23
238
18
162
1.11
0.12
1.6
1.8
5355.92
16530.56
e6/l
1.66
12
122
164
1618
1.02
0.05
1.4
1.4
—
—
—
0
0
11
100
1.10
0.05
3.5
2.8
—
—
—
0
0
45
436
1.03
0.05
1.4
1.4
—
—
—
0
0
15
140
1.07
0.04
1.2
1.3
—
—
—
0
0
87
886
0.98
0.04
1.3
1.2
—
—
—
0
0
11
103
1.07
0.02
3.5
2.7
103.36
105.03
mmol/l
0.41
11
103
11
103
1.07
0.02
3.5
2.7
4.29
4.09
mmol/l
0.97
11
103
14
147
0.95
0.01
1.2
1.2
—
—
—
0
0
21
204
1.03
0.00
15.3
10.2
—
—
—
0
0
22
226
0.97
0.00
1.7
1.6
—
—
—
0
0
11
108
1.02
0.00
1.6
1.5
—
—
—
0
0
28
278
1.01
0.00
3.2
2.9
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
7
76
0.92
-0.00
1.6
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
188.80
—
0
5
0
5
0.00
-0.00
0.0
1.0
—
0.06
—
0
5
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
—
—
0
0
7
78
0.90
-0.00
1.3
1.2
—
—
—
0
0
7
74
0.95
-0.00
1.6
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.4
—
41.63
—
0
8
7
74
0.95
-0.00
1.6
1.5
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.3
—
1.95
—
0
8

Mortality – FinRegistry

Association

Association between endpoint H7_OPTNERVNAS and mortality.

Females

Parameter HR [95% CI] p-value
H7_OPTNERVNAS 1.359 [1.17, 1.58] < 0.001
Birth year 0.993 [0.98, 1.0] 0.108

During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1941 females with H7_OPTNERVNAS died.

Males

Parameter HR [95% CI] p-value
H7_OPTNERVNAS 1.46 [1.26, 1.69] < 0.001
Birth year 0.989 [0.98, 1.0] 0.016

During the follow-up period (1.1.1998 — 31.12.2019), 567 out of 1962 males with H7_OPTNERVNAS died.

Mortality risk

Mortality risk for people of age

years, who have H7_OPTNERVNAS.

N-year risk Females Males
1 0.108% 0.271%
5 0.801% 2.134%
10 2.05% 4.791%
15 3.769% 8.823%
20 6.255% 14.356%

Relationships between endpoints

Index endpoint: H7_OPTNERVNAS – Disorders of optic nerve, not elsewhere classified

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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