No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
714 |
4. Check minimum number of eventsNone |
714 |
5. Include endpointsNone |
714 |
6. Filter based on genotype QC (FinnGen only) |
714 |
Control definitions (FinnGen only)
- Control exclude
- H7_OPTNERVE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H47
- Name in latin
- Morbositates nervi optici non alibi classificatae
Similar endpoints
↥List of similar endpoints to
Disorders of optic nerve, not elsewhere classified
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 5048 | 2489 | 2516 |
| Only index persons | 4410 | 2212 | 2198 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.07 | 0.07 | 0.07 |
| Only index persons | 0.08 | 0.08 | 0.08 |
| Median age at first event (years) | |||
| Whole population | 62.97 | 63.63 | 62.38 |
| Only index persons | 62.67 | 63.16 | 62.18 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 714 | 362 | 352 |
| Unadjusted period prevalence (%) | 0.14 | 0.12 | 0.16 |
| Median age at first event (years) | 61.87 | 59.28 | 64.52 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 635
- Matched controls
- 6347
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
323.0
594
*
XCK00
NOMESCO Finland
Perimetry
16.4
125.8
217
195
H47.1
ICD-10 Finland
Papilloedema, unspecified
+∞
110.7
103
*
H46
ICD-10 Finland
Optic neuritis
1057.7
95.5
91
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.5
47.7
204
610
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
6.0
47.5
144
294
XCK10
NOMESCO Finland
Photography of fundus of eye
5.5
47.3
158
363
H47.2
ICD-10 Finland
Optic atrophy
+∞
46.4
44
*
H53.4
ICD-10 Finland
Visual field defects
16.7
44.9
73
49
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
10.0
36.9
76
85
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
47.1
36.4
44
10
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
5.9
36.2
109
216
XCD10
NOMESCO Finland
Electrophysiological examination of eye
11.8
36.1
68
64
XCW99
NOMESCO Finland
Other investigative procedure of eye
4.3
35.6
149
422
37799
ICD-8 Finland
Other diseases of retina and optic nerve, Unspecified
+∞
34.7
33
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
6.2
34.3
98
181
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
31.5
30
*
H53.1
ICD-10 Finland
Subjective visual disturbances
5.6
29.0
90
183
G35
ICD-10 Finland
Multiple sclerosis
25.2
27.3
38
16
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
23.8
25.5
36
16
CS494
NOMESCO Finland
Other visual field testing
10.1
24.4
49
52
TAB00
NOMESCO Finland
Lumbar puncture
6.1
24.2
68
122
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
119.1
21.7
23
*
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
45.0
21.5
26
6
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
35.1
21.3
27
8
109
Kela drug reimbursment
Multiple sclerosis
31.2
20.7
27
9
Z3229
NOMESCO Finland
Other healthcare associate professional
3.7
20.4
96
292
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
7.7
20.1
47
65
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
27.0
19.3
26
10
PAW37
NOMESCO Finland
Biopsy of temporal artery
20.1
18.3
27
14
H53.9
ICD-10 Finland
Visual disturbance, unspecified
6.2
16.3
44
75
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.8
16.1
117
480
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
11.6
15.9
29
26
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
87.2
15.6
17
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.0
15.5
314
2088
N86
ICPC
Multiple sclerosis
82.0
14.6
16
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
14.5
185
1012
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
8.7
14.1
30
36
Z3231
NOMESCO Finland
Registered nurse
2.1
14.1
201
1151
XCD20
NOMESCO Finland
Photoangiography of eye
8.4
13.4
29
36
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
3.2
13.3
74
253
G93.2
ICD-10 Finland
Benign intracranial hypertension
+∞
12.5
12
*
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
6.3
12.3
32
53
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
6.3
11.9
31
51
H34.1
ICD-10 Finland
Central retinal artery occlusion
12.9
11.7
20
16
R51.80
ICD-10 Finland
Headache
2.4
11.6
104
475
L03AX13
ATC
glatiramer acetate; parenteral
122.1
11.5
12
*
L03AB07
ATC
interferon beta-1a; parenteral
25.5
11.2
15
6
3774A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic nerve
+∞
10.4
10
*
S01EC01
ATC
acetazolamide; systemic
5.6
10.2
29
54
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
17.0
9.9
15
9
L04AX07
ATC
dimethyl fumarate; oral
55.8
9.7
11
*
H02AB06
ATC
prednisolone; systemic
1.7
9.1
299
2195
H54.4
ICD-10 Finland
Blindness, monocular
37.2
9.0
11
*
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.1
8.9
48
163
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
9.7
8.8
17
18
PA6BD
NOMESCO Finland
Extensive CT of neck arteries
3.3
8.7
43
137
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
11.8
8.6
15
13
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.2
8.6
87
420
H40.0
ICD-10 Finland
Glaucoma suspect
2.7
8.6
59
235
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
91.2
8.4
9
*
H54.1
ICD-10 Finland
Severe visual impairment, binocular
+∞
8.3
8
*
H47.7
ICD-10 Finland
Disorder of visual pathways, unspecified
+∞
8.3
8
*
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
7.0
8.1
19
28
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
8.0
175
1130
ZXA10
NOMESCO Finland
Bilateral
1.9
8.0
132
778
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
7.1
7.8
18
26
F05
ICPC
Visual disturbance other
4.2
7.8
28
69
H40.11
ICD-10 Finland
Low pressure glaucoma
4.9
7.5
23
48
H34.8
ICD-10 Finland
Other retinal vascular occlusions
4.4
7.4
25
58
H25.1
ICD-10 Finland
Senile nuclear cataract
1.7
7.3
176
1166
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
30.4
7.2
9
*
B01AC04
ATC
clopidogrel; oral
1.9
7.2
112
647
H53.8
ICD-10 Finland
Other visual disturbances
6.1
7.1
18
30
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
1.6
7.0
202
1408
A02BC02
ATC
pantoprazole; systemic
1.6
6.9
396
3260
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
2.7
6.9
44
168
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
6.8
6.8
16
24
114
Kela drug reimbursment
Glaucoma
2.3
6.8
64
301
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
2.6
6.8
47
188
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
1.9
6.7
108
627
L03AB08
ATC
interferon beta-1b; parenteral
70.5
6.4
7
*
H47
ICD-10 Finland
Other disorders of optic [2nd] nerve and visual pathways
+∞
6.3
6
*
164
Kela drug reimbursment
Fingolimod
+∞
6.3
6
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
2.3
6.2
53
237
WX892
NOMESCO Finland
Monitored bed care
2.3
6.2
55
248
N05CF01
ATC
zopiclone; oral
1.6
6.2
205
1467
S01ED51
ATC
timolol, combinations; ophthalmic
2.3
6.2
55
250
S01CA01
ATC
dexamethasone and antiinfectives; ophthalmic (ophth., corticosteroids and antiinfectives in comb.)
1.6
6.2
216
1567
XF400
NOMESCO Finland
ECG with 12 standard connections
1.8
6.2
104
612
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
6.1
129
819
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.5
6.0
248
1867
H3603, E113
ICD-10 Finland
NA
6.1
6.0
15
25
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTNERVNAS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNERVNAS | 1.359 [1.17, 1.58] | < 0.001 |
| Birth year | 0.993 [0.98, 1.0] | 0.108 |
During the follow-up period (1.1.1998 — 31.12.2019), 489 out of 1941 females with H7_OPTNERVNAS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTNERVNAS | 1.46 [1.26, 1.69] | < 0.001 |
| Birth year | 0.989 [0.98, 1.0] | 0.016 |
During the follow-up period (1.1.1998 — 31.12.2019), 567 out of 1962 males with H7_OPTNERVNAS died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTNERVNAS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.108% | 0.271% |
| 5 | 0.801% | 2.134% |
| 10 | 2.05% | 4.791% |
| 15 | 3.769% | 8.823% |
| 20 | 6.255% | 14.356% |
Relationships between endpoints
↥Index endpoint: H7_OPTNERVNAS – Disorders of optic nerve, not elsewhere classified
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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