Optic neuritis

H7_OPTNEURITIS

optic neuritis: Optic neuritis is inflammation of the optic nerve, the nerve that carries the visual signal from the eye to the brain.The conditionmay cause sudden, reduced vision in the affected eye(s). While the cause of optic neuritis is unknown, it has been associated with autoimmune diseases, infections, multiple sclerosis , drug toxicity and deficiency of vitamin B-12. Vision often returns to normal within 2-3 weeks without treatment. In some cases, corticosteroids are given to speed recovery. If known, the underlying cause should be treated.

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Endpoint definition

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Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 H46
  • Hospital discharge: ICD-9 3773
  • Hospital discharge: ICD-8 3670[2-9]
  • Cause of death: ICD-10 H46
  • Cause of death: ICD-9 3773
  • Cause of death: ICD-8 3670[2-9]

2 out of 7 registries used, show all original rules.

1716

4. Check minimum number of events

None

1716

5. Include endpoints

None

1716

6. Filter based on genotype QC (FinnGen only)

1629

Control definitions (FinnGen only)

Control exclude
H7_OPTNERVE

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2
Parent code in ICD-10
H46-H48
Name in latin
Neuritis optica

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 10403 6920 3413
Only index persons 9515 6484 3031
Unadjusted period prevalence (%)
Whole population 0.16 0.20 0.10
Only index persons 0.20 0.24 0.12
Median age at first event (years)
Whole population 36.47 35.70 38.00
Only index persons 35.76 35.17 37.00

-FinnGen-

Key figures

All Female Male
Number of individuals 1629 1225 404
Unadjusted period prevalence (%) 0.37 0.43 0.19
Median age at first event (years) 36.77 35.83 39.63

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1716
Matched controls
17160
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
L04AA27
ATC
[U] fingolimod
146.9
320.8
160
12
N04BB01
ATC
amantadine; oral
34.0
319.6
207
69
157
Kela drug reimbursment
Dimethyl fumarate, glatiramer acetate, interferon beta and teriflunomid (Multiple sclerosis)
170.2
307.7
614
56
TAB00
NOMESCO Finland
Lumbar puncture
16.0
307.7
453
377
109
Kela drug reimbursment
Multiple sclerosis
197.3
307.7
729
64
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
12.5
307.7
621
743
353
Kela drug reimbursment
Cladribine and fingolimod
138.2
307.7
196
16
L04AA31
ATC
[U] teriflunomide
142.2
307.7
167
13
164
Kela drug reimbursment
Fingolimod
132.0
307.7
219
19
L03AB07
ATC
interferon beta-1a; parenteral
172.3
307.7
377
28
H46
ICD-10 Finland
Optic neuritis
4503599627370496.0
307.7
1490
*
N86
ICPC
Multiple sclerosis
159.1
307.7
280
21
L03AX13
ATC
glatiramer acetate; parenteral
129.6
307.7
282
26
L04AX07
ATC
dimethyl fumarate; oral
105.6
307.7
213
23
G37.9
ICD-10 Finland
Demyelinating disease of central nervous system, unspecified
72.1
307.7
263
43
G35
ICD-10 Finland
Multiple sclerosis
204.4
307.7
890
90
303
Kela drug reimbursment
Dimethyl fumarate, interferon beta, glatiramer acetate and teriflunomid (Multiple sclerosis)
194.9
307.7
661
55
XCK00
NOMESCO Finland
Perimetry
23.2
307.7
527
322
L03AB08
ATC
interferon beta-1b; parenteral
124.5
292.2
148
13
N07XX09
ATC
[U] dimethyl fumarate
93.7
248.7
130
15
XCD10
NOMESCO Finland
Electrophysiological examination of eye
18.4
235.1
194
118
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
12.6
219.8
227
205
Z01.0
ICD-10 Finland
Examination of eyes and vision
5.2
217.9
612
1656
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
15.3
200.7
182
132
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
11.7
181.4
195
186
M03BX01
ATC
baclofen; systemic
14.6
180.6
168
127
2AB04, ,
NOMESCO Finland
71.8
175.0
95
14
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
37.7
165.7
103
29
H53.1
ICD-10 Finland
Subjective visual disturbances
6.5
163.8
301
546
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.4
150.6
346
770
XA800
NOMESCO Finland
Neuropsychological investigation
7.8
146.0
216
310
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
5.5
139.6
303
639
NA7CG
NOMESCO Finland
Spine and spinal cord extensive MRI examination with high intensity magnet
16.1
136.9
119
79
XKD06
NOMESCO Finland
Physiologic investigation of micturition
10.6
129.8
147
150
AA1BG
NOMESCO Finland
Standard MRI examination of brain with high intensity magnet
4.7
123.2
334
845
36703
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica, retrobulbaris
+∞
122.4
116
*
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
122.4
116
*
H53.4
ICD-10 Finland
Visual field defects
13.0
120.1
118
97
N06BA07
ATC
modafinil; oral
27.6
115.5
79
30
R29.8
ICD-10 Finland
Other and unspecified symptoms and signs involving the nervous and musculoskeletal systems
4.5
104.6
288
733
G97.0
ICD-10 Finland
Cerebrospinal fluid leak from spinal puncture
10.4
98.8
112
114
G04BD09
ATC
trospium; oral
10.2
91.2
105
109
H47.2
ICD-10 Finland
Optic atrophy
+∞
90.4
86
*
XKD00
NOMESCO Finland
Uroflowmetry
4.0
86.2
273
766
ZX120
NOMESCO Finland
Intravenous
4.0
85.7
273
769
H48.1*G35
ICD-10 Finland
Retrobulbar neuritis in multiple sclerosis
+∞
84.1
80
*
F02.89*G35
ICD-10 Finland
Dementia in multiple sclerosis
284.1
80.2
81
*
NA1CG
NOMESCO Finland
Cervical spine extensive MRI examination with high intensity magnet
9.1
75.9
95
110
H47.1
ICD-10 Finland
Papilloedema, unspecified
771.3
75.9
74
*
XCK10
NOMESCO Finland
Photography of fundus of eye
4.0
74.7
232
639
3773B
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS RETROBULBARIS]
+∞
74.5
71
*
CS494
NOMESCO Finland
Other visual field testing
8.5
74.4
98
121
G04BD12
ATC
mirabegron; oral
3.7
71.2
256
780
N31.9
ICD-10 Finland
Neuromuscular dysfunction of bladder, unspecified
16.2
71.2
61
39
H57.1
ICD-10 Finland
Ocular pain
5.0
69.6
160
348
G36.0
ICD-10 Finland
Neuromyelitis optica [Devic]
334.3
64.9
65
*
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
4.4
63.6
169
413
H53.9
ICD-10 Finland
Visual disturbance, unspecified
5.5
62.5
125
240
NA7DG
NOMESCO Finland
Spine and spinal cord very extensive MRI examination with high intensity magnet
10.9
62.4
68
65
R1250
NOMESCO Finland
Evaluation of functional capability
6.6
60.8
101
162
Z3231
NOMESCO Finland
Registered nurse
2.4
60.7
563
2857
XKC03
NOMESCO Finland
Water cystometry
6.3
60.5
105
176
L04AG12
ATC
ofatumumab; parenteral
608.8
60.1
59
*
KCV12
NOMESCO Finland
Urinary bladder endoscopic botulin therapy
15.2
59.8
53
36
L03AB13
ATC
peginterferon beta-1a; parenteral
598.0
59.1
58
*
UKC02
NOMESCO Finland
Cystoscopy
3.1
58.3
280
1015
L04AE01
ATC
fingolimod; oral
301.9
57.6
58
*
L04AK02
ATC
teriflunomide; oral
83.1
57.4
64
8
3400A
ICD-9 Finland
Multiple sclerosis[SCLEROSIS MULTIPLEX (DISSEMINATA)]
200.0
56.3
58
*
TAB22
NOMESCO Finland
Stoppin epidural fluid escape with coagulated blood
8.0
56.0
77
100
N03AX12
ATC
[U] gabapentin; oral
2.7
55.4
371
1605
G36.9
ICD-10 Finland
Acute disseminated demyelination, unspecified
79.1
54.3
61
8
R20.2
ICD-10 Finland
Paraesthesia of skin
3.4
54.2
219
714
NA7BG
NOMESCO Finland
Spine and spinal cord MRI examination with high intensity magnet
14.2
51.2
47
34
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
12.9
50.5
49
39
TKC22
NOMESCO Finland
Catheterisation instruction
8.0
50.4
69
89
H02AB04
ATC
methylprednisolone; systemic
2.7
50.1
329
1403
KC1EE
NOMESCO Finland
Ultrasound measurement of residual urine
3.3
48.9
206
688
36702
ICD-8 Finland
Inflammation of optic nerve and retina, Neuritis optica. Papillitis
+∞
48.1
46
*
L04AA40
ATC
cladribine; oral
131.3
48.0
51
*
G04BD04
ATC
oxybutynin; oral, transdermal
4.2
47.4
134
342
Z3229
NOMESCO Finland
Other healthcare associate professional
3.4
47.1
186
596
N03AE01
ATC
clonazepam; systemic
3.8
47.1
154
436
G04BD08
ATC
solifenacin; oral
3.9
45.7
142
388
L04AA52
ATC
[U] ofatumumab; parenteral
459.5
45.5
45
*
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
3.6
44.5
156
463
NA2CG
NOMESCO Finland
Thoracal spine extensive MRI examination with high intensity magnet
9.7
44.3
52
55
4AA23, ,
NOMESCO Finland
73.4
44.2
50
7
AA1DM
NOMESCO Finland
Very extensive MRI examination of brain with 3 Tesla magnet
11.2
43.4
46
42
H53.2
ICD-10 Finland
Diplopia
4.9
42.9
97
207
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
3.9
40.9
125
337
3773A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[PAPILLITIS OPTICA]
+∞
39.7
38
*
G04BD07
ATC
tolterodine; oral
4.1
38.9
109
276
H04.10
ICD-10 Finland
Dry eye syndrome
2.5
37.3
256
1105
R33
ICD-10 Finland
Retention of urine
3.7
37.3
126
364
R4150
NOMESCO Finland
Neuropsychological rehabilitation
8.4
36.1
47
57
NA2BG
NOMESCO Finland
Thoracal spine MRI examination with high intensity magnet
5.0
35.8
79
165
N03AX16
ATC
[U] pregabalin
2.1
35.4
431
2367
O99.3
ICD-10 Finland
Mental disorders and diseases of the nervous system complicating pregnancy, childbirth and the puerperium
4.6
35.1
86
196
N32.82
ICD-10 Finland
Instability of the detrusor vesicae muscle
7.7
34.9
49
65
Z3226
NOMESCO Finland
Physiotherapist
2.2
33.6
347
1784
Z03.3
ICD-10 Finland
Observation for suspected nervous system disorder
3.2
33.5
143
479
A02BC02
ATC
pantoprazole; systemic
1.9
32.7
1156
8944
TKC20
NOMESCO Finland
Catheterisation of bladder
3.3
32.0
124
391
CA1CM
NOMESCO Finland
Eye and orbita extensive MRI examination with 3 Tesla magnet
48.5
31.6
38
8
34099
ICD-8 Finland
Multiple sclerosis
318.5
30.9
31
*
Z2445
NOMESCO Finland
Psychologist
3.3
30.3
118
373
C10AC01
ATC
colestyramine; oral
4.5
29.9
75
174
AA1BM
NOMESCO Finland
MRI examination of brain with 3 Tesla magnet
6.3
29.7
50
81
L04AX01
ATC
azathioprine; systemic
3.4
29.2
110
341
H57.9
ICD-10 Finland
Disorder of eye and adnexa, unspecified
7.9
29.0
40
52
G95.8
ICD-10 Finland
Other specified diseases of spinal cord
44.6
28.7
35
8
SPAT1229
SPAT
Assessment of need for aid
3.1
28.6
127
435
G04BD11
ATC
fesoterodine; oral
5.3
28.4
58
113
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
5.5
28.2
55
103
L28
ICPC
Limited function/disability (L)
2.2
28.0
266
1315
N28
ICPC
Limited function/disability (N)
6.4
27.9
46
73
N02BF01
ATC
gabapentin; oral
2.5
27.0
176
737
N05CF01
ATC
zopiclone; oral
1.8
26.8
530
3380
R35
ICD-10 Finland
Polyuria
3.0
26.7
125
441
N31.8
ICD-10 Finland
Other neuromuscular dysfunction of bladder
22.2
25.7
37
17
H02AB06
ATC
prednisolone; systemic
1.7
25.2
804
5848
H20.1
ICD-10 Finland
Chronic iridocyclitis
7.0
25.1
38
55
H49.2
ICD-10 Finland
Sixth [abducent] nerve palsy
9.2
24.8
30
33
R4110
NOMESCO Finland
Physiotherapy
1.8
24.4
456
2844
J01EA01
ATC
trimethoprim; systemic
1.8
24.3
485
3087
XKD03
NOMESCO Finland
Urethral pressure profilometry
4.8
24.2
55
118
H53.8
ICD-10 Finland
Other visual disturbances
5.5
23.9
46
85
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
23.9
273
1445
D32.02
ICD-10 Finland
Benign tumor of the meninges at the base of the brain
8.5
23.2
30
36
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
23.0
22
*
H02AB07
ATC
prednisone; oral
2.1
22.5
244
1264
N06AX16
ATC
venlafaxine; oral
1.9
22.5
313
1772
AA1AD
NOMESCO Finland
CT of head and brain
1.8
22.4
376
2261
GD1AA
NOMESCO Finland
Thorax X-ray examination
1.7
22.3
657
4635
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
2.6
21.9
132
531
N31.2
ICD-10 Finland
Flaccid neuropathic bladder, not elsewhere classified
7.5
21.7
31
42
G50.0
ICD-10 Finland
Trigeminal neuralgia
4.4
20.7
52
121
H20.0
ICD-10 Finland
Acute and subacute iridocyclitis
3.1
20.6
90
305
R90.8
ICD-10 Finland
Other abnormal findings on diagnostic imaging of central nervous system
5.6
20.1
38
69
XF400
NOMESCO Finland
ECG with 12 standard connections
2.0
20.1
225
1178
N32.83
ICD-10 Finland
Nozzle synergy in the bladder neck
27.4
20.0
27
10
U13
ICPC
Bladder symptom/complaint other
3.6
19.8
65
184
ZXA10
NOMESCO Finland
Bilateral
1.9
19.6
286
1640
N03AF01
ATC
carbamazepine; oral, rectal
2.8
19.3
100
373
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
7.6
19.1
27
36
F05
ICPC
Visual disturbance other
3.4
19.0
68
204
N39.4
ICD-10 Finland
Other specified urinary incontinence
2.3
18.9
149
678
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
1.9
18.6
243
1342
R51.80
ICD-10 Finland
Headache
1.8
18.5
326
1978
G04CA02
ATC
tamsulosin; oral
2.0
18.5
211
1110
RF120, ,
NOMESCO Finland
5.7
18.2
34
61
N03AF02
ATC
oxcarbazepine; oral
3.1
18.2
76
251
N29
ICPC
Neurological sympt/complt other
4.3
18.2
47
112
CA1BG
NOMESCO Finland
Eye and orbita MRI examination with high intensity magnet
16.7
17.9
28
17
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.6
17.7
638
4666
G81.9
ICD-10 Finland
Hemiplegia, unspecified
5.8
17.1
31
54
R5110, ,
SPAT
2.6
17.1
103
415
A28
ICPC
Limited function/disability NOS
2.0
17.0
194
1021
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
1.6
16.8
462
3156
N30.0
ICD-10 Finland
Acute cystitis
1.8
16.8
293
1770
Z2446
NOMESCO Finland
Social worker
2.3
16.7
130
588
XCH00
NOMESCO Finland
Eye pressure measurement
2.9
16.5
77
271
N99
ICPC
Neurological disease other
5.2
16.5
34
67
R4120
NOMESCO Finland
Occupational therapy
2.4
16.3
121
536
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
12.9
16.2
28
22
R42
ICD-10 Finland
Dizziness and giddiness
1.7
16.2
336
2132
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
15.9
326
2059
M03BX02
ATC
tizanidine; oral
1.5
15.7
1093
9146
SPAT1215
SPAT
Assessment of need for medical rehabilitation
2.7
15.6
83
314
Z2221
NOMESCO Finland
Medical doctor
1.6
15.5
483
3393
N06AA09
ATC
amitriptyline; systemic
2.1
15.5
155
777
TCW99
NOMESCO Finland
Other minor procedure in eye surgery
5.8
15.4
28
49
R2130
NOMESCO Finland
Counselling and guidance which enhance independent living
2.2
15.3
135
643
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
1.6
15.2
435
2989
WD325
NOMESCO Finland
Demanding therapy of methastized malignancy with biomodifiers
5.7
15.1
28
50
ZXE15
NOMESCO Finland
Procedure duration 120 to 149 minutes
3.4
15.0
54
163
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.0
15.0
186
1007
N02AX02
ATC
tramadol; systemic, rectal
1.5
14.7
634
4776
H48.1
ICD-10 Finland
Retrobulbar neuritis in diseases classified elsewhere
+∞
14.6
14
*
L89
ICD-10 Finland
Decubitus ulcer and pressure area
4.7
14.5
33
71
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
1.9
14.4
201
1131
H30.2
ICD-10 Finland
Posterior cyclitis
13.5
14.2
24
18
R39.1
ICD-10 Finland
Other difficulties with micturition
3.5
14.0
48
140
J01MA02
ATC
ciprofloxacin; systemic
1.5
14.0
562
4157
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
3.8
13.6
41
110
L04AX09
ATC
diroximel fumarate; oral
+∞
13.6
13
*
36709
ICD-8 Finland
Inflammation of optic nerve and retina, Unspecified
+∞
13.6
13
*
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.5
13.5
637
4864
CA1DG
NOMESCO Finland
Eye and orbita very extensive MRI examination with high intensity magnet
34.3
13.5
17
5
N31.1
ICD-10 Finland
Reflex neuropathic bladder, not elsewhere classified
10.1
13.5
26
26
H51.2
ICD-10 Finland
Internuclear ophthalmoplegia
141.1
13.5
14
*
R50.9
ICD-10 Finland
Fever, unspecified
1.7
13.2
244
1493
G51.0
ICD-10 Finland
Bell palsy
3.2
12.9
51
163
G04CA01
ATC
alfuzosin; oral
2.1
12.9
119
577
N06AB04
ATC
citalopram; systemic
1.6
12.9
350
2365
N03AX09
ATC
lamotrigine; oral
2.2
12.7
114
547
U07
ICPC
Urine symptom/complaint other
2.2
12.7
113
541
SPAT1216
SPAT
Assessment of functional ability
1.8
12.5
189
1088
Z96.1
ICD-10 Finland
Presence of intraocular lens
2.0
12.5
144
758
J01CA08
ATC
pivmecillinam; oral
1.4
12.3
750
5988
H54.7
ICD-10 Finland
Unspecified visual loss
10.6
12.3
23
22
RF420, ,
NOMESCO Finland
4.1
12.1
33
82
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
12.1
179
1025
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.5
11.8
406
2888
A06AC01
ATC
ispaghula (psylla seeds); oral
1.6
11.8
374
2615
A02BC01
ATC
omeprazole; systemic
1.5
11.7
400
2842
Z46.8
ICD-10 Finland
Fitting and adjustment of other specified devices
3.3
11.7
44
137
ZXE10
NOMESCO Finland
More than one and less than three hours
1.5
11.6
531
4004
RS221, ,
NOMESCO Finland
3.9
11.6
33
85
R10.1
ICD-10 Finland
Pain localized to upper abdomen
1.6
11.5
302
2020
ABD30
NOMESCO Finland
Implantation of spinal stimulation device
5.1
11.5
24
48
N06AX21
ATC
duloxetine; oral
1.7
11.5
214
1311
H54.0
ICD-10 Finland
Blindness, binocular
120.8
11.4
12
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
3.4
11.4
41
124
NA3BG
NOMESCO Finland
Lumbar spine MRI examination with high intensity magnet
1.8
11.2
165
944
SPAT1231
SPAT
Assessment of adjustments needed in living environment
4.2
11.1
29
70
H54.4
ICD-10 Finland
Blindness, monocular
14.0
11.0
18
13
U02
ICPC
Urinary frequency/urgency
1.7
10.8
221
1388
G97.1
ICD-10 Finland
Other reaction to spinal and lumbar puncture
17.9
10.7
16
9
U04
ICPC
Incontinence urine
2.4
10.7
72
306
K59.00
ICD-10 Finland
Constipation caused by slow bowel passage (SCT)
3.3
10.7
39
119
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
2.2
10.7
86
396
N18
ICPC
Paralysis/weakness
4.0
10.3
29
74
S01EC01
ATC
acetazolamide; systemic
3.5
10.3
35
102
H53
ICD-10 Finland
Visual disturbances
4.6
10.3
24
53
Z50.9
ICD-10 Finland
Care involving use of rehabilitation procedure, unspecified
2.4
10.2
70
300
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
1.7
10.0
173
1036
H35.39
ICD-10 Finland
Degeneration of macula and posterior pole
3.2
9.9
38
120
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
1.8
9.8
136
763
J01AA02
ATC
doxycycline; systemic
1.4
9.8
1233
10999
F01
ICPC
Eye pain
2.6
9.8
57
227
N02BE01
ATC
paracetamol; systemic, rectal
1.6
9.7
1452
13378
A02BA02
ATC
ranitidine; systemic
1.6
9.7
254
1694
L01BB04
ATC
cladribine; systemic
55.3
9.7
11
*
G04BD01
ATC
emepronium; systemic
5.3
9.6
19
36
F43.22
ICD-10 Finland
Adaptation disorder with mixed anxiety and depression
2.0
9.6
103
529
A06AD11
ATC
lactulose; oral
1.7
9.6
166
994
N30.9
ICD-10 Finland
Cystitis, unspecified
2.0
9.4
100
512
H25.8
ICD-10 Finland
Other senile cataract
2.1
9.4
92
457
WW400
NOMESCO Finland
Plasmaferesis
17.6
9.4
14
8
WX408
NOMESCO Finland
General anesthesy, balanced
1.5
9.4
374
2728
AAB00
NOMESCO Finland
Extirpation of intracranial lesion
4.4
9.3
23
53
TKC10
NOMESCO Finland
Percutaneous puncture of bladder
6.9
9.3
22
32
S06.0
ICD-10 Finland
Concussion
1.7
9.2
169
1031
RF410, ,
NOMESCO Finland
3.9
9.1
26
67
N05BA01
ATC
diazepam; systemic, rectal
1.7
9.1
193
1220
ZXY02
NOMESCO Finland
Neuropsychologist
5.0
9.1
19
38
R06.0
ICD-10 Finland
Dyspnoea
1.5
9.1
367
2683
H54.5
ICD-10 Finland
Severe visual impairment, monocular
10.1
9.0
17
17
PAW37
NOMESCO Finland
Biopsy of temporal artery
10.1
9.0
17
17
U05
ICPC
Urination problems other
2.3
9.0
66
293
R15
ICD-10 Finland
Faecal incontinence
2.8
8.9
43
155
R51.81
ICD-10 Finland
Facial pain NOS
2.6
8.9
49
190
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
4.7
8.8
20
43
H52.1
ICD-10 Finland
Myopia
2.2
8.8
76
360
D32.00
ICD-10 Finland
Benign tumor of the meninges on the outer surface of the cerebrum
4.0
8.8
24
60
WX892
NOMESCO Finland
Monitored bed care
2.0
8.8
98
512
NA7CM
NOMESCO Finland
Spine and spinal cord extensive MRI examination with 3 Tesla magnet
50.2
8.7
10
*
M05BA04
ATC
alendronic acid; oral
2.0
8.6
90
459
A04
ICPC
Weakness/tiredness general
1.6
8.6
223
1482
Z50.1
ICD-10 Finland
Other physical therapy
2.1
8.6
79
384
6BA02, ,
NOMESCO Finland
10.1
8.5
16
16
H02AB09
ATC
hydrocortisone; systemic
2.7
8.5
44
165
SPAT1220
SPAT
Assessment of need for rehabilitation and/or rehabilitation plan
2.1
8.5
81
400
A02BC03
ATC
lansoprazole; oral
1.4
8.4
393
2948
3773X
ICD-9 Finland
Disorders of optic nerve and visual pathways, Optic neuritis[NEURITIS OPTICA ALIA SEU NUD]
+∞
8.3
8
*
NA1BM
NOMESCO Finland
Cervical spine MRI examination with 3 Tesla magnet
10.8
8.3
15
14
G40.9
ICD-10 Finland
Epilepsy, unspecified
2.4
8.2
56
240
ZXE00
NOMESCO Finland
One hour or less
1.4
8.2
605
4900
N06CA01
ATC
amitriptyline and psycholeptics; systemic
1.7
8.1
145
876
Z01.8
ICD-10 Finland
Other specified special examinations
1.5
8.1
337
2472
4AA36, ,
NOMESCO Finland
33.5
8.1
10
*
N07AA03
ATC
distigmine; systemic
22.1
8.0
11
5
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
1.6
8.0
184
1188
J01XE01
ATC
nitrofurantoin; oral
3.0
7.9
34
115
U29
ICPC
Urinary symptom/complaint other
2.6
7.9
44
172
AA1AG
NOMESCO Finland
Short MRI examination of brain with median intensity magnet
3.2
7.8
30
95
NA1CM
NOMESCO Finland
Cervical spine extensive MRI examination with 3 Tesla magnet
10.8
7.8
14
13
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
2.7
7.8
40
150
F32.11
ICD-10 Finland
Moderate depressive episode with somatic syndrome
2.3
7.8
59
266
KCW98
NOMESCO Finland
Other transluminal endoscopic operation on bladder
45.2
7.7
9
*
K59.09
ICD-10 Finland
Constipation, unspecified
2.0
7.7
83
429
R02
ICPC
Shortness of breath/dyspnoea
1.6
7.6
173
1114
G93.2
ICD-10 Finland
Benign intracranial hypertension
25.1
7.6
10
*
F43.21
ICD-10 Finland
Adaptation disorder with prolonged depression
3.8
7.5
22
58
JN3BD
NOMESCO Finland
Extensive abdominal CT
1.7
7.5
129
772
F32.9
ICD-10 Finland
Depressive episode, unspecified
1.5
7.5
230
1587
S01EA05
ATC
brimonidine; ophthalmic
3.2
7.4
29
93
ABD40
NOMESCO Finland
Implantation of spinal injection device
80.4
7.4
8
*
G37.3
ICD-10 Finland
Acute transverse myelitis in demyelinating disease of central nervous system
80.4
7.4
8
*
R52.9
ICD-10 Finland
Pain, unspecified
1.7
7.4
146
907
ZXE17
NOMESCO Finland
Procedure duration 150 to 179 minutes
3.4
7.4
26
78
J01.0
ICD-10 Finland
Acute maxillary sinusitis
1.4
7.3
451
3537
G37.0
ICD-10 Finland
Diffuse sclerosis
+∞
7.3
7
*
34109
ICD-8 Finland
Other demyelinating diseases of central nervous system, Unspecified
+∞
7.3
7
*
H55
ICD-10 Finland
Nystagmus and other irregular eye movements
6.9
7.3
17
25
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
9.4
7.3
14
15
N06AX11
ATC
mirtazapine; oral
1.4
7.2
513
4110
WYA30
NOMESCO Finland
Treatment of a patient needing special arrangements
1.7
7.2
132
803
N05CD07
ATC
temazepam; oral
1.7
7.2
129
780
RS222, ,
NOMESCO Finland
3.7
7.2
22
60
G04BD10
ATC
darifenacin; oral
7.3
7.2
16
22
K80.2
ICD-10 Finland
Calculus of gallbladder without cholecystitis
1.6
7.1
172
1124
EB1AA
NOMESCO Finland
Intraoral radiographic dental examination
1.3
7.1
901
7845
S82.1
ICD-10 Finland
Fracture of upper end of tibia
2.8
7.0
33
118
308
Kela drug reimbursment
Alprostadil, sildenafil and combination product containing aviptadil and phentolamine
4.2
7.0
18
43
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.4
7.0
437
3432
R60.0
ICD-10 Finland
Localized oedema
1.6
6.9
147
930
G44.2
ICD-10 Finland
Tension-type headache
1.5
6.9
238
1682
XF600
NOMESCO Finland
Bloodpressure measurement
1.9
6.9
81
432
SPAT1167
SPAT
Insertion of urinary catheter
2.8
6.9
32
114
NA1AD
NOMESCO Finland
Cervical spine CT examination
2.0
6.8
67
335
PA2BD
NOMESCO Finland
Extensive CT angiography of brain
3.0
6.8
29
98
KE1BE
NOMESCO Finland
Rectal ultrasound examinaiton of prostata
2.1
6.8
63
308
R5210
NOMESCO Finland
Assessment of the improvements needed in the living environment
16.8
6.7
10
6
W19
ICD-10 Finland
Unspecified fall
1.7
6.7
131
812
SPAT1262
SPAT
Handing over of treatment supplies
1.5
6.7
207
1430
F43.29
ICD-10 Finland
Adaptation disorder UNS
2.2
6.7
51
231
G37.8
ICD-10 Finland
Other specified demyelinating diseases of central nervous system
22.6
6.7
9
*
SPAT1301
SPAT
No procedures
1.4
6.7
420
3298
J01MA12
ATC
levofloxacin; systemic
1.5
6.7
224
1574
XCD20
NOMESCO Finland
Photoangiography of eye
3.7
6.6
20
54
N04BC05
ATC
pramipexole; oral
1.8
6.6
95
540
CA1ME
NOMESCO Finland
Ultrasound oculometry
7.8
6.6
14
18
H54.6
ICD-10 Finland
Moderate visual impairment, monocular
12.3
6.6
11
9
G04.9
ICD-10 Finland
Encephalitis, myelitis and encephalomyelitis, unspecified
12.3
6.6
11
9
H34.1
ICD-10 Finland
Central retinal artery occlusion
12.3
6.6
11
9
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
1.6
6.6
134
840
S29
ICPC
Skin symptom/complaint other
1.4
6.6
259
1877
H34.2
ICD-10 Finland
Other retinal artery occlusions
8.7
6.6
13
15
N31.0
ICD-10 Finland
Uninhibited neuropathic bladder, not elsewhere classified
8.7
6.6
13
15
ZXE21
NOMESCO Finland
Procedure duration at least 3 but less than 4 hours
5.3
6.5
18
34
N30
ICD-10 Finland
Cystitis
1.6
6.4
138
876
H43.8
ICD-10 Finland
Other disorders of vitreous body
1.7
6.4
114
689
SPAT1256
SPAT
Intramuscular and subcutaneous injection
1.3
6.4
550
4518
R32
ICD-10 Finland
Unspecified urinary incontinence
2.6
6.4
36
142
CJB10
NOMESCO Finland
Laser discission of secondary cataract
1.9
6.3
75
402
C03CA01
ATC
furosemide; systemic
1.4
6.3
267
1962
G04BE03
ATC
sildenafil; oral
3.9
6.3
18
47
H01BA02
ATC
desmopressin; nasal, systemic, sublingual
2.7
6.3
32
120
G36.8
ICD-10 Finland
Other specified acute disseminated demyelination
+∞
6.3
6
*
RD210, ,
NOMESCO Finland
2.8
6.2
30
109
SPAT1226
SPAT
Implementation of occupational therapy rehabilitation plan
2.8
6.2
30
109
D50.9
ICD-10 Finland
Iron deficiency anaemia, unspecified
1.7
6.2
100
588
M31.5
ICD-10 Finland
Giant cell arteritis with polymyalgia rheumatica
5.0
6.2
18
36
R1220
NOMESCO Finland
Psychological examination of need and possibilities to rehabilitation
3.4
6.1
21
62
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.3
6.1
637
5363
H15.0
ICD-10 Finland
Scleritis
7.7
6.1
13
17
H54.3
ICD-10 Finland
Mild or no visual impairment, binocular
10.1
6.0
11
11
Z71.8
ICD-10 Finland
Other specified counselling
1.3
6.0
500
4081
S30.0
ICD-10 Finland
Contusion of lower back and pelvis
1.9
6.0
67
351

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
239
130
21.20
306.74
1.2
1.2
41.70
35.26
mg/l
0.87
184
104
235
125
21.62
304.59
1.1
1.0
205.57
218.81
mg/l
0.58
200
106
159
19
92.13
303.49
3.0
1.8
—
—
—
0
0
202
108
21.07
260.49
1.8
1.5
—
—
—
0
0
249
219
13.13
245.82
1.2
1.2
—
—
—
0
0
276
344
9.37
212.01
1.2
1.3
401.91
472.26
mg/l
2.05
259
326
248
280
10.18
205.34
1.2
1.5
—
—
—
0
0
186
142
14.57
199.16
1.1
1.1
—
—
—
0
0
456
1051
5.55
193.78
3.3
2.6
9.79
10.50
g/l
4.04
414
979
246
309
9.13
187.12
1.3
1.5
334.46
1907.15
e6/l
0.93
194
258
245
309
9.08
185.72
1.2
1.5
9.07
13.08
e6/l
0.53
183
251
150
113
14.45
161.34
3.6
2.4
1.30
1.31
e9/l
0.03
132
106
217
310
7.87
147.29
1.2
1.3
3.56
3.69
mmol/l
0.96
200
292
124
83
16.03
142.14
3.9
2.4
0.23
0.21
e9/l
0.36
107
77
124
85
15.65
140.32
3.8
2.4
480.55
613.84
e6/l
0.65
105
77
83
28
31.10
126.32
1.0
1.0
4.77
5.59
mg/g
0.89
78
28
374
1036
4.34
122.67
2.7
2.3
27.79
24.14
au/ml
0.20
13
104
1152
6619
3.25
115.29
12.7
6.2
—
—
—
0
0
1114
6358
3.14
111.20
11.9
5.9
0.74
0.67
%
4.34
1081
5969
127
131
10.39
111.09
1.1
1.6
—
—
—
0
0
1135
6609
3.12
108.07
11.9
5.8
2.99
2.78
%
2.53
1104
6227
1140
6660
3.12
107.79
12.1
6.1
8.93
8.13
%
17.80
1108
6296
1180
7038
3.17
107.32
12.2
5.8
0.04
0.04
e9/l
0.15
1087
6204
1178
7029
3.16
106.86
12.1
5.8
0.56
0.55
e9/l
1.28
1087
6200
1195
7272
3.12
102.97
12.1
5.8
1.69
1.94
e9/l
13.22
1114
6576
1155
6898
3.06
102.97
11.9
5.8
26.65
28.89
%
11.15
1121
6537
1196
7300
3.11
102.12
12.1
6.1
0.19
0.18
e9/l
0.53
1107
6536
1142
6814
3.02
101.28
11.5
5.6
58.98
56.80
%
9.28
1109
6453
93
70
13.99
99.55
1.1
1.1
1631.82
1599.27
miu/ml
0.07
93
70
72
33
22.73
98.01
3.2
2.1
79.67
191.36
e6/l
1.58
30
22
1247
8079
2.99
89.92
13.1
8.8
3.79
4.01
e9/l
3.76
1152
7139
115
140
8.73
88.50
1.2
1.7
—
—
—
0
0
275
821
3.80
79.20
3.4
1.7
1.07
1.37
g/l
3.42
268
766
542
2569
2.62
69.01
3.9
2.4
4.67
7.35
e6/l
6.07
506
2304
688
3744
2.40
64.08
5.2
2.9
18.43
100.29
e6/l
2.37
583
2813
639
3370
2.43
63.82
4.6
2.7
—
—
—
0
0
57
40
14.71
63.23
2.2
2.0
—
—
—
0
0
788
4573
2.34
62.99
5.9
3.4
90.61
82.33
e6/l
0.10
614
3052
507
2425
2.55
62.41
3.7
2.7
534.51
540.60
mosm/kgh2o
0.24
467
2097
922
5736
2.31
62.29
2.6
2.3
86.27
74.88
nmol/l
19.59
867
5302
636
3388
2.39
61.68
4.8
2.8
0.13
0.38
e6/l
7.82
535
2511
964
6242
2.24
57.40
13.8
8.4
0.00
0.00
e9/l
0.77
847
5135
64
70
9.46
53.30
1.3
1.4
83.63
77.67
%
—
8
9
1295
9679
2.38
51.69
7.1
3.9
—
—
—
0
0
182
585
3.36
45.87
1.6
1.3
—
—
—
0
0
812
5222
2.05
45.51
4.6
4.5
37.10
36.44
g/l
2.91
770
4889
1227
9188
2.18
45.28
7.9
3.9
74.38
2140.77
e6/l
1.71
21
110
258
1021
2.80
45.21
5.1
4.1
0.32
0.63
%
2.44
80
308
46
43
10.96
42.75
1.2
1.1
13.75
18.00
%
—
8
5
269
1118
2.67
42.71
5.3
4.2
0.48
0.96
%
3.95
86
360
260
1064
2.70
42.56
5.4
4.3
0.04
0.14
%
2.55
77
303
643
3873
2.06
42.39
4.0
2.6
—
—
—
0
0
247
1007
2.70
40.63
5.4
4.4
0.03
0.76
%
0.90
64
249
971
6924
1.93
37.77
5.6
3.3
0.00
0.00
estimate
0.80
261
1374
977
6987
1.92
37.60
5.5
3.3
0.00
0.01
estimate
1.06
255
1281
294
1350
2.42
37.54
1.3
1.5
—
—
—
0
0
966
6922
1.91
36.52
7.3
4.5
0.00
0.00
estimate
0.37
254
1327
102
261
4.09
35.83
4.5
3.9
59.53
56.85
%
1.23
102
261
821
5615
1.89
35.53
4.6
3.0
6.02
5.91
ph
0.51
62
552
100
254
4.12
35.48
4.4
3.6
3.57
4.09
e9/l
2.16
100
254
1014
7457
1.88
34.53
4.3
4.4
6.26
6.48
mmol/l
3.31
959
6840
555
3494
1.87
29.87
9.1
6.5
—
—
—
0
0
50
84
6.10
28.66
4.0
3.1
52.03
45.10
%
1.69
34
46
910
6704
1.76
28.47
5.8
5.7
9.99
10.66
umol/l
0.92
865
6355
1263
10256
1.88
28.28
7.7
7.0
74.47
74.64
u/l
0.04
1202
9696
36
45
8.15
26.93
1.2
1.1
124.54
62.71
ng/l
—
13
7
358
2020
1.98
26.38
4.5
2.4
0.90
1.29
e6/l
0.78
216
1090
320
1742
2.03
26.07
2.0
2.1
29.42
29.48
s
0.08
309
1684
362
2078
1.94
25.25
1.5
1.6
—
—
—
0
0
111
386
3.01
24.28
1.6
2.1
9.28
10.91
mg/l
1.85
105
361
336
1905
1.95
24.22
4.6
2.6
3.29
3.38
e6/l
0.07
194
979
478
3110
1.74
21.79
4.7
3.3
—
—
—
0
0
232
1214
2.05
20.78
6.9
3.4
—
—
—
0
0
1227
10318
1.66
19.42
4.2
3.9
10.37
10.33
mm/h
0.03
1145
9662
598
4233
1.63
19.39
2.4
3.2
2.34
2.35
mmol/l
0.18
536
3828
1580
14372
2.25
18.84
16.3
11.6
19.84
20.45
mg/l
0.30
1268
11155
1560
14160
2.12
18.05
15.2
12.2
139.66
139.59
mmol/l
0.51
1532
13799
1563
14204
2.13
17.92
15.3
12.3
3.91
3.93
mmol/l
2.14
1527
13814
686
5134
1.56
17.00
9.1
10.6
1.11
1.15
inr
1.05
237
1636
509
3555
1.61
16.97
2.2
2.1
120.42
192.35
u/l
2.55
480
3377
474
3264
1.62
16.70
4.5
3.5
97.55
95.08
%
1.62
468
3165
471
3250
1.62
16.41
1.6
1.7
—
—
—
0
0
456
3163
1.60
15.39
2.1
1.4
2.03
2.25
g/l
2.91
320
2028
546
3986
1.54
14.60
5.5
2.9
—
—
—
0
0
192
1070
1.89
14.15
2.8
2.2
4212.09
5559.81
u/l
0.20
49
434
1625
15215
2.28
13.66
15.0
9.1
26.17
25.77
u/l
0.37
1592
14790
501
3672
1.51
12.84
7.0
3.6
0.00
0.01
estimate
1.28
251
1299
85
359
2.44
12.78
2.2
2.9
—
—
—
0
0
152
815
1.95
12.55
1.8
2.7
68.53
67.44
g/l
1.09
142
755
1171
10176
1.47
12.17
4.3
2.9
43.70
40.29
u/l
0.70
1119
9681
746
5982
1.44
11.83
6.0
6.1
1.22
1.22
mmol/l
0.56
619
5116
83
362
2.36
11.64
1.4
1.2
—
—
—
0
0
676
5342
1.44
11.52
5.3
5.5
1.21
1.22
mmol/l
0.11
621
4920
522
3949
1.46
11.13
1.9
1.9
—
—
—
0
0
1407
12786
1.56
11.02
22.0
13.8
14.23
14.46
%
1.06
1394
12569
476
3545
1.47
10.98
4.2
3.7
7.39
7.40
ph
1.09
104
672
39
119
3.33
10.70
1.2
1.8
—
—
—
0
0
62
251
2.53
10.25
1.6
1.8
0.50
0.75
g/l
1.77
47
191
605
4799
1.40
9.64
3.9
3.1
28.58
29.97
u/l
0.65
578
4580
563
4418
1.41
9.53
3.2
3.0
39.30
46.33
ng/l
0.19
322
2453
44
155
2.89
9.52
1.6
1.4
0.34
0.41
g/l
0.85
31
109
44
155
2.89
9.52
1.6
1.4
2.67
2.90
g/l
0.37
32
109
44
156
2.87
9.42
1.6
1.4
5.91
6.92
g/l
1.10
32
111
44
160
2.80
9.00
1.6
1.4
—
—
—
0
0
37
126
2.98
8.53
3.9
3.4
—
—
—
0
0
303
2158
1.49
8.50
1.5
1.4
478.87
554.11
titre
0.49
71
448
91
477
1.96
8.07
1.8
1.8
0.23
0.23
g/l
0.12
86
448
428
3294
1.40
7.85
3.5
3.2
—
—
—
0
0
389
2947
1.41
7.81
6.0
4.0
—
—
—
0
0
225
1532
1.54
7.78
3.1
2.5
6.09
7.34
umol/l
0.66
189
1310
92
496
1.90
7.53
1.8
1.8
1.12
1.18
g/l
1.30
87
464
588
4859
1.32
6.60
1.9
1.8
99.25
97.78
pmol/l
0.29
300
2618
156
1027
1.57
6.26
2.1
2.5
4.03
5.63
e9/l
1.64
140
896
1433
13436
1.40
6.24
5.5
4.8
1.77
2.16
mu/l
1.18
1348
12638
259
1909
1.42
5.97
3.3
3.2
0.83
0.82
mmol/l
0.17
249
1812
204
1442
1.47
5.87
4.8
5.5
1.05
1.03
mmol/l
0.49
185
1344
109
674
1.66
5.67
1.8
2.3
—
—
—
0
0
51
248
2.09
5.65
4.0
3.0
1.67
2.41
mmol/l
1.65
28
158
179
1253
1.48
5.42
3.4
2.3
34.88
40.37
u/l
0.56
149
1057
1585
15218
1.54
5.40
14.9
10.8
—
—
—
0
0
1664
16197
1.90
5.09
26.4
17.1
40.46
40.53
%
0.09
1581
15391
56
298
1.91
4.87
3.9
3.0
7.41
7.42
ph
1.14
51
261
260
1992
1.36
4.72
1.8
1.7
1170.06
1177.73
nmol/l
0.05
198
1552
140
961
1.50
4.68
4.3
3.2
1.22
1.23
mmol/l
0.83
127
826
1663
16212
1.83
4.64
26.6
17.1
262.00
260.85
e9/l
0.32
1638
15884
1664
16227
1.84
4.61
26.5
17.0
90.77
90.37
fl
3.64
1648
16059
1271
13471
0.78
4.58
3.4
3.5
1.27
1.26
mmol/l
0.19
1185
12668
1664
16229
1.84
4.58
26.4
17.0
30.19
30.13
pg
0.81
1648
16059
1664
16232
1.83
4.53
26.5
17.1
4.50
4.52
e12/l
0.56
1636
15871
1664
16232
1.83
4.53
26.6
17.1
6.56
6.70
e9/l
1.54
1633
15867
216
1620
1.38
4.48
2.3
2.3
21.68
23.48
%
1.25
181
1393
1664
16239
1.81
4.42
26.7
17.2
135.32
135.36
g/l
0.05
1647
16065
158
1128
1.44
4.34
3.6
2.6
1.63
1.78
%
1.58
141
1009
15
46
3.28
4.19
1.0
1.4
—
—
—
0
0
152
1087
1.44
4.15
2.4
2.3
0.23
0.22
g/l
0.10
146
1031
487
4127
1.25
4.11
2.5
2.4
60.11
57.74
u/l
0.23
453
3851
28
123
2.30
4.04
1.6
1.8
—
—
—
0
0
28
124
2.28
3.97
3.9
2.6
—
—
—
0
0
48
261
1.86
3.97
1.1
1.1
—
—
—
0
0
12
27
4.47
3.93
1.5
1.0
—
—
—
0
0
229
1774
1.34
3.87
2.3
2.2
2.41
2.42
g/l
0.06
208
1654
20
77
2.62
3.81
1.4
3.4
—
—
—
0
0
43
229
1.90
3.80
3.0
2.6
—
—
—
0
0
64
389
1.67
3.65
1.3
1.3
74.44
86.05
titre
—
9
38
330
2706
1.27
3.64
1.6
1.5
19.74
20.55
nmol/l
0.51
286
2379
25
110
2.29
3.62
1.8
3.0
—
—
—
0
0
1336
13987
0.80
3.60
3.7
3.8
1.48
1.50
mmol/l
0.56
1237
13212
150
2010
0.72
3.58
1.3
1.3
—
—
—
0
0
273
2191
1.29
3.57
3.0
3.3
458.28
381.37
ng/l
0.12
155
1388
328
2695
1.27
3.56
2.5
2.9
957.12
955.39
ng/l
0.00
275
2238
41
223
1.86
3.43
1.2
1.4
—
—
—
0
0
67
420
1.62
3.41
1.4
2.1
1.51
1.44
g/l
0.26
57
368
181
1388
1.34
3.29
2.7
2.0
365.18
371.52
nmol/l
0.10
169
1287
31
156
2.01
3.25
2.2
1.3
62.85
64.63
mmol/l
0.08
26
134
199
1551
1.32
3.24
2.2
1.6
—
—
—
0
0
393
3330
1.23
3.23
1.8
1.7
0.76
0.95
mg/l
1.73
290
2471
112
795
1.44
3.23
2.3
2.6
66.18
72.81
e9/l
1.44
95
597
1232
11620
1.21
3.22
4.6
4.2
14.57
14.47
pmol/l
0.80
1144
10841
242
1942
1.29
3.17
2.3
2.2
12.95
13.97
umol/l
1.37
223
1810
81
543
1.52
3.12
1.2
1.2
—
—
—
0
0
33
176
1.89
2.96
1.2
1.3
—
—
—
0
0
29
148
1.98
2.95
1.3
1.1
—
—
—
0
0
82
1179
0.68
2.95
1.7
1.7
—
—
—
0
0
6
9
6.68
2.87
4.3
3.7
—
—
—
0
0
1350
14041
0.82
2.83
3.7
3.8
4.75
4.78
mmol/l
0.53
1263
13318
30
158
1.91
2.81
1.7
1.5
—
—
—
0
0
10
271
0.37
2.78
2.0
3.6
200.10
26.59
u/ml
—
10
264
173
2180
0.77
2.71
1.4
1.5
—
—
—
0
0
123
918
1.37
2.70
7.2
7.6
8.55
8.28
mmol/l
0.17
116
881
985
9185
1.17
2.63
3.2
3.2
—
—
—
0
0
13
49
2.67
2.62
1.8
1.3
—
6.33
%
—
0
12
21
100
2.11
2.59
1.5
1.3
70.57
72.08
umol/l
0.13
21
100
20
94
2.14
2.55
1.7
1.5
30.40
36.32
%
—
10
57
199
1617
1.26
2.38
1.6
1.4
—
—
—
0
0
21
104
2.03
2.36
1.0
1.0
—
—
—
0
0
135
1046
1.32
2.34
3.4
3.4
4.54
4.55
pmol/l
0.07
121
939
1375
14214
0.84
2.27
4.0
4.1
2.84
2.86
mmol/l
0.54
1272
13406
23
120
1.93
2.26
1.3
1.8
32.87
31.89
pg
0.46
23
120
22
113
1.96
2.25
1.1
1.2
—
73.22
—
0
10
115
876
1.34
2.25
2.3
1.6
364.69
304.02
mu/l
0.88
101
785
20
100
2.01
2.21
1.0
1.0
—
—
—
0
0
13
54
2.42
2.20
3.1
2.8
—
—
—
0
0
140
1104
1.29
2.15
1.4
1.3
361.30
214.67
u/ml
0.35
128
1024
12
49
2.46
2.10
2.2
3.1
23.29
30.88
umol/l
—
7
40
24
131
1.84
2.08
1.5
1.1
—
—
—
0
0
11
43
2.57
2.08
1.0
1.2
—
—
—
0
0
160
1954
0.80
1.96
1.6
1.9
—
—
—
0
0
38
242
1.58
1.93
2.7
2.4
—
—
—
0
0
374
3308
1.17
1.88
2.3
2.1
2.96
2.83
mg/l
0.47
326
2851
7
22
3.19
1.88
2.1
2.1
—
—
—
0
0
96
734
1.33
1.88
1.2
1.3
196.96
226.48
miu/ml
0.31
31
374
8
28
2.87
1.86
1.0
1.0
—
—
—
0
0
50
342
1.48
1.86
2.8
2.2
—
—
—
0
0
35
221
1.60
1.85
2.5
2.2
14.94
16.19
%
0.98
15
106
413
3697
1.15
1.77
1.3
1.3
1.57
1.63
u/ml
0.03
113
1026
340
3000
1.17
1.76
6.0
3.6
1.02
1.02
kg/l
0.20
45
415
16
81
1.98
1.75
1.2
1.9
—
—
—
0
0
21
117
1.80
1.74
1.0
1.2
—
—
—
0
0
5
13
3.85
1.71
1.0
1.0
—
—
—
0
0
47
324
1.46
1.70
2.1
2.3
—
—
—
0
0
59
425
1.40
1.69
1.1
1.3
2.14
2.50
u/ml
—
5
52
53
376
1.42
1.66
1.1
1.3
40.47
42.13
u/ml
—
6
42
295
2589
1.17
1.64
1.8
1.6
434.27
34510932.75
pmol/l
2.87
257
2237
19
105
1.82
1.63
1.1
1.1
2.37
0.56
nmol/l
—
6
17
32
205
1.57
1.63
1.7
1.7
—
—
—
0
0
17
91
1.88
1.60
1.2
1.4
6.37
6.77
u/l
0.14
11
76
85
656
1.31
1.59
3.7
3.1
7.42
7.41
ph
0.12
12
83
7
26
2.70
1.58
1.1
1.2
—
—
—
0
0
239
2069
1.18
1.57
2.1
2.5
119.07
108.47
ug/g
0.18
174
1649
23
137
1.69
1.55
1.9
1.7
53.54
53.69
%
0.01
13
90
13
64
2.04
1.54
1.1
1.1
—
—
—
0
0
39
267
1.47
1.49
2.4
2.8
1.01
0.89
nmol/l
0.44
32
224
76
585
1.31
1.47
1.2
1.2
—
—
—
0
0
77
596
1.31
1.44
4.9
3.0
—
—
—
0
0
40
278
1.45
1.43
1.5
1.6
—
—
—
0
0
109
885
1.25
1.40
3.2
2.5
—
—
—
0
0
245
2150
1.16
1.38
2.4
2.7
2.43
2.43
mmol/l
0.25
212
1884
6
23
2.61
1.37
1.5
1.1
—
—
—
0
0
119
980
1.23
1.35
5.9
3.2
—
—
—
0
0
31
208
1.50
1.33
2.6
2.5
—
—
—
0
0
0
40
0.00
1.32
0.0
2.5
—
707.53
—
0
34
19
113
1.69
1.32
1.1
1.2
—
—
—
0
0
629
5877
1.11
1.31
2.2
2.0
—
—
—
0
0
8
34
2.36
1.29
1.0
1.1
—
—
—
0
0
8
34
2.36
1.29
1.0
1.1
—
—
—
0
0
8
34
2.36
1.29
1.0
1.1
—
—
—
0
0
531
5711
0.90
1.28
2.5
2.4
—
—
—
0
0
172
1479
1.18
1.26
1.3
1.3
—
—
—
0
0
70
547
1.29
1.25
1.4
1.3
11.36
10.80
u/l
0.09
59
452
62
477
1.31
1.24
3.8
3.1
—
—
—
0
0
28
188
1.50
1.21
1.2
1.3
—
—
—
0
0
8
37
2.17
1.21
2.0
2.0
44.38
52.10
ug/l
—
8
37
307
2766
1.13
1.20
1.3
1.3
26.25
27.28
iu/ml
0.05
77
905
151
1291
1.19
1.19
1.2
1.2
—
—
—
0
0
16
94
1.71
1.17
2.3
2.3
5.00
2.60
u/field
—
7
50
0
33
0.00
1.16
0.0
2.4
—
4876.20
—
0
20
75
600
1.26
1.14
1.9
1.8
—
—
—
0
0
26
175
1.49
1.13
2.3
2.4
—
—
—
0
0
5
115
0.43
1.11
1.0
1.2
—
—
—
0
0
37
268
1.39
1.11
1.2
1.2
2.71
5.32
u/ml
1.52
17
117
30
209
1.44
1.11
1.2
1.8
—
1210.00
—
0
8
104
872
1.21
1.04
7.0
8.4
—
—
—
0
0
16
98
1.64
1.03
1.8
1.1
—
—
—
0
0
21
138
1.53
1.03
1.2
1.1
—
—
—
0
0
12
202
0.59
1.02
1.3
1.6
7.53
7.58
mmol/l
0.07
12
192
135
1163
1.17
1.01
4.1
3.7
—
—
—
0
0
134
1155
1.17
0.99
5.1
8.4
0.96
1.04
mmol/l
0.09
96
908
16
249
0.64
0.99
1.3
1.4
6.25
7.10
mmol/l
0.79
16
220
55
432
1.28
0.99
1.2
1.2
—
—
—
0
0
36
266
1.36
0.98
1.0
1.1
—
—
—
0
0
197
1750
1.14
0.98
2.6
1.9
—
—
—
0
0
0
29
0.00
0.97
0.0
2.1
—
—
—
0
0
0
29
0.00
0.97
0.0
1.1
—
—
—
0
0
16
100
1.61
0.96
2.6
2.5
—
—
—
0
0
18
116
1.56
0.96
2.9
2.7
1.19
1.57
g/24h
—
7
61
55
434
1.28
0.96
3.7
3.2
0.29
0.25
g/l
0.17
25
164
92
770
1.21
0.95
2.5
2.2
11.62
11.77
nmol/l
0.05
81
699
460
4295
1.10
0.95
2.7
2.1
—
—
—
0
0
54
426
1.28
0.95
2.0
2.0
5.36
4.62
iu/l
0.11
18
164
14
85
1.65
0.94
3.4
3.0
44021.43
38679.39
ug/l
0.45
14
85
41
312
1.32
0.94
2.0
1.7
—
—
—
0
0
113
966
1.18
0.94
4.9
3.4
2.19
1.92
mmol/l
0.44
97
799
45
350
1.29
0.89
1.3
1.4
24.88
23.43
u/l
0.13
38
298
210
1889
1.13
0.88
1.2
1.2
—
—
—
0
0
23
323
0.71
0.88
2.2
2.3
4.43
4.76
umol/l
0.10
15
240
52
647
0.80
0.86
1.3
1.4
—
—
—
0
0
117
1012
1.17
0.86
5.3
9.0
96.59
96.12
%
0.80
112
979
8
44
1.82
0.86
3.7
2.2
—
—
—
0
0
6
31
1.94
0.84
1.0
8.5
—
—
—
0
0
52
644
0.80
0.83
1.3
1.4
—
—
—
0
0
11
66
1.67
0.78
1.1
1.1
—
—
—
0
0
60
726
0.82
0.78
1.1
1.1
—
—
—
0
0
132
1164
1.15
0.77
5.2
8.3
4.99
5.08
kpa
0.67
126
1112
132
1164
1.15
0.77
5.2
8.3
13.04
12.93
kpa
0.08
126
1115
22
157
1.41
0.76
3.0
2.8
—
—
—
0
0
35
270
1.30
0.76
3.3
3.6
39.56
28.77
mg/l
0.51
26
220
9
53
1.70
0.75
1.6
3.2
—
—
—
0
0
147
1310
1.13
0.74
1.2
1.2
228.80
156.09
iu/ml
0.79
52
527
55
664
0.82
0.72
1.3
1.5
—
—
—
0
0
7
41
1.71
0.70
1.1
2.2
16.24
16.80
umol/l
—
7
41
11
69
1.60
0.68
1.1
1.1
125.09
209.70
iu/ml
1.18
11
69
9
59
1.53
0.68
1.6
1.4
—
—
—
0
0
104
1181
0.87
0.67
1.4
1.4
—
—
—
0
0
7
43
1.63
0.67
5.4
3.1
—
—
—
0
0
34
270
1.26
0.62
3.4
3.6
53.71
71.20
mg/l
0.26
25
221
11
71
1.55
0.62
2.0
1.6
1.93
5.06
nmol/l
—
6
54
237
2194
1.09
0.62
4.8
4.3
2.02
2.38
ug/l
0.61
215
1982
742
7166
1.06
0.61
2.9
2.8
99.34
89.94
ug/l
0.70
705
6755
0
20
0.00
0.60
0.0
1.5
—
—
—
0
0
0
21
0.00
0.60
0.0
2.6
—
—
—
0
0
0
22
0.00
0.59
0.0
7.2
—
—
—
0
0
10
64
1.57
0.58
2.5
2.5
54.20
49.25
umol/l
—
10
53
8
54
1.48
0.57
1.0
1.6
—
—
—
0
0
8
54
1.48
0.57
1.4
1.6
—
—
—
0
0
32
396
0.80
0.56
1.2
1.3
—
—
—
0
0
62
533
1.17
0.55
6.2
12.0
—
—
—
0
0
76
664
1.15
0.55
4.1
5.9
—
—
—
0
0
192
1773
1.09
0.54
1.3
1.2
—
—
—
0
0
25
195
1.29
0.54
1.2
1.7
—
—
—
0
0
9
60
1.50
0.54
1.7
1.3
—
—
—
0
0
22
283
0.77
0.53
1.1
1.0
2.33
2.04
u/ml
—
9
146
27
338
0.80
0.53
1.1
1.3
—
—
—
0
0
26
205
1.27
0.52
3.2
3.8
—
—
—
0
0
6
40
1.50
0.51
1.7
1.6
—
—
—
0
0
11
75
1.47
0.50
1.0
1.5
138.36
138.53
nmol/l
0.00
11
75
62
538
1.16
0.50
2.2
2.1
20.71
20.98
s
0.24
55
466
31
379
0.81
0.50
1.0
1.1
7.69
6.15
u/ml
0.21
14
201
10
67
1.50
0.49
1.1
1.5
88.70
169.15
mmol/24h
—
10
67
1268
12871
0.94
0.49
22.3
14.6
332.31
332.57
g/l
0.53
1260
12775
11
77
1.43
0.45
2.5
2.1
13.10
10.88
%
0.99
11
77
27
219
1.24
0.45
1.3
1.4
—
—
—
0
0
29
238
1.22
0.44
1.1
1.1
23.83
2003.75
iu/ml
—
6
65
45
386
1.17
0.43
2.5
2.8
—
—
—
0
0
11
78
1.41
0.43
1.1
1.1
392.64
376.74
u/l
0.03
11
70
427
4442
0.95
0.42
1.6
1.6
—
—
—
0
0
20
158
1.27
0.41
1.5
1.6
—
—
—
0
0
21
167
1.26
0.41
1.1
1.3
—
—
—
0
0
30
359
0.83
0.41
1.0
1.1
0.24
1.22
u/ml
—
8
151
0
16
0.00
0.41
0.0
9.0
—
—
—
0
0
8
59
1.36
0.41
2.1
3.2
—
—
—
0
0
336
3212
1.06
0.40
2.8
2.1
—
—
—
0
0
39
453
0.86
0.39
7.8
8.9
—
—
—
0
0
0
19
0.00
0.39
0.0
1.2
—
57.90
—
0
5
22
178
1.24
0.39
1.5
1.5
—
—
—
0
0
91
830
1.10
0.37
2.1
2.2
6.25
7.43
ug/l
0.33
72
741
93
853
1.10
0.35
3.8
3.7
79.81
78.90
ng/l
0.04
83
764
22
181
1.22
0.34
1.1
1.3
—
0.47
nmol/l
—
0
11
33
283
1.17
0.34
8.5
3.7
—
—
—
0
0
275
2633
1.05
0.32
1.3
1.3
6.33
10.96
u/ml
0.94
100
1105
43
379
1.14
0.32
1.4
1.4
320.74
310.60
ug/g
0.10
26
205
34
391
0.87
0.32
1.6
1.4
0.70
0.45
nmol/l
0.50
27
320
340
3280
1.05
0.30
2.1
2.3
1104.42
4503.80
umol/l
2.90
303
2919
37
326
1.14
0.29
1.2
1.2
313.26
251.45
u/ml
0.53
23
202
28
323
0.86
0.28
1.0
1.1
—
—
—
0
0
28
322
0.87
0.27
1.0
1.1
—
—
—
0
0
13
104
1.25
0.26
5.1
6.8
—
—
—
0
0
5
74
0.67
0.26
1.2
1.0
—
—
—
0
0
31
273
1.14
0.25
1.7
1.8
5946.73
11167.65
e6/l
1.11
22
206
45
407
1.11
0.24
7.2
4.8
—
—
—
0
0
11
87
1.27
0.24
1.5
1.1
—
—
—
0
0
16
133
1.20
0.24
1.1
1.0
0.72
0.96
u/ml
—
5
34
130
1232
1.06
0.24
1.5
1.3
25.61
26.41
iu/l
0.10
116
1059
26
227
1.15
0.24
2.6
2.7
—
—
—
0
0
66
611
1.08
0.23
3.5
2.9
—
—
—
0
0
5
40
1.25
0.22
2.0
1.3
—
—
—
0
0
15
125
1.20
0.22
1.1
1.0
0.20
3.18
u/ml
—
5
26
14
116
1.21
0.22
1.1
1.1
—
—
—
0
0
673
6617
1.03
0.21
2.8
2.5
—
—
—
0
0
0
11
0.00
0.21
0.0
1.7
—
—
—
0
0
0
11
0.00
0.21
0.0
1.2
—
—
—
0
0
0
11
0.00
0.21
0.0
1.0
—
0.04
—
0
5
0
11
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
1.3
—
—
—
0
0
0
10
0.00
0.21
0.0
2.1
—
—
—
0
0
112
1062
1.06
0.21
3.2
4.2
5.12
27.74
ug/l
1.73
96
831
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
8.00
—
0
6
38
344
1.11
0.21
4.0
8.1
1.26
1.22
mmol/l
0.13
32
297
0
13
0.00
0.21
0.0
2.2
—
39.54
—
0
13
0
14
0.00
0.20
0.0
1.1
—
15.98
—
0
14
0
14
0.00
0.20
0.0
2.3
—
3.84
—
0
5
79
742
1.07
0.20
2.3
3.0
162.48
146.64
ng/l
0.19
73
664
9
115
0.78
0.20
1.0
1.2
—
—
—
0
0
30
269
1.12
0.19
2.5
2.4
20.58
112.68
ug/min
2.84
21
174
6
50
1.20
0.19
1.0
1.2
—
—
—
0
0
6
50
1.20
0.19
1.0
1.1
—
—
—
0
0
36
327
1.10
0.19
2.9
3.3
1.69
1.37
mg/l
1.06
30
305
44
478
0.92
0.19
1.1
1.1
0.94
4.01
u/ml
—
5
75
99
942
1.05
0.18
1.3
1.2
—
—
—
0
0
82
865
0.95
0.17
2.9
2.1
—
—
—
0
0
5
66
0.76
0.17
1.8
2.5
—
14.33
—
0
7
8
68
1.18
0.16
1.3
1.3
—
—
—
0
0
38
412
0.92
0.16
1.1
1.1
3.17
2.72
u/ml
0.13
22
212
82
862
0.95
0.15
2.9
2.1
—
—
—
0
0
30
274
1.10
0.15
4.1
3.6
38.25
24.23
mg/l
1.07
19
178
1249
12413
1.02
0.15
4.7
4.8
38.21
38.50
mmol/mol
0.53
1162
11718
57
604
0.94
0.14
2.0
2.3
—
—
—
0
0
30
275
1.09
0.14
1.4
1.3
100.00
106.45
u/ml
—
9
53
8
100
0.80
0.13
1.3
1.2
—
—
—
0
0
147
1516
0.97
0.13
1.4
1.4
—
—
—
0
0
1340
13464
0.98
0.13
3.8
3.9
5.69
5.75
mmol/l
0.98
1228
12562
32
296
1.08
0.13
1.4
1.4
—
—
—
0
0
27
248
1.09
0.12
2.6
2.1
124.23
129.70
g/l
0.64
22
186
82
855
0.96
0.12
2.9
2.1
—
—
—
0
0
50
473
1.06
0.12
1.2
1.2
—
—
—
0
0
344
3495
0.98
0.11
1.5
1.6
1.41
1.37
mmol/l
0.32
285
3015
335
3297
1.02
0.11
4.4
3.9
9.28
9.24
mg/mmol
0.00
199
2096
71
683
1.04
0.10
3.1
2.1
—
—
—
0
0
5
44
1.14
0.10
1.0
1.1
—
—
—
0
0
370
3650
1.02
0.10
3.8
3.3
7.61
7.76
mmol/l
0.24
315
3161
82
849
0.96
0.10
2.9
2.0
—
—
—
0
0
34
361
0.94
0.10
1.0
1.1
4.10
1.96
u/ml
0.23
15
174
5
46
1.09
0.09
1.6
1.5
—
—
—
0
0
5
46
1.09
0.09
1.6
3.5
—
—
—
0
0
41
389
1.06
0.09
4.0
3.4
51.39
1167.81
u/ml
1.55
36
330
5
48
1.04
0.09
3.6
2.2
5.02
2.14
ug/l
—
5
41
152
1486
1.03
0.09
3.9
3.8
32.01
31.98
%
0.01
119
1087
11
124
0.89
0.09
1.8
2.3
—
—
—
0
0
11
124
0.89
0.09
1.2
1.3
—
—
—
0
0
6
56
1.07
0.08
1.5
1.3
—
—
—
0
0
6
57
1.05
0.08
43.3
29.9
7.65
7.48
ug/l
—
6
52
7
68
1.03
0.07
1.0
2.1
20.03
139.35
ug/l
—
7
59
11
98
1.12
0.07
2.5
2.2
—
—
—
0
0
6
74
0.81
0.07
1.8
1.5
—
—
—
0
0
8
78
1.03
0.07
1.1
1.4
155.00
157.17
pmol/l
—
8
78
15
138
1.09
0.06
1.8
1.2
2.62
0.97
u/ml
—
10
68
9
100
0.90
0.06
1.2
1.3
1.60
1.58
g/l
—
9
100
9
100
0.90
0.06
1.1
1.2
—
—
—
0
0
9
103
0.87
0.06
1.1
1.1
—
—
—
0
0
317
3142
1.01
0.05
3.8
3.3
782.49
340.50
mg/l
0.52
186
2014
32
307
1.04
0.05
1.0
1.1
—
—
—
0
0
93
912
1.02
0.05
1.3
1.4
—
—
—
0
0
70
716
0.98
0.04
1.0
1.1
—
—
—
0
0
26
272
0.96
0.04
1.0
1.2
—
—
—
0
0
127
1289
0.98
0.04
2.7
2.8
0.70
0.74
ug/l
0.21
74
767
33
318
1.04
0.04
1.0
1.1
2.01
3.74
u/ml
0.88
23
151
97
986
0.98
0.04
1.2
1.2
—
—
—
0
0
244
2460
0.99
0.03
1.6
1.7
—
—
—
0
0
28
290
0.96
0.03
1.1
1.1
—
—
—
0
0
107
1082
0.99
0.02
1.6
1.4
—
—
—
0
0
27
263
1.03
0.01
1.0
1.0
0.03
0.35
u/ml
—
7
77
61
617
0.99
0.01
1.7
1.7
—
—
—
0
0
12
114
1.05
0.00
1.1
1.0
—
—
—
0
0
17
164
1.04
0.00
1.1
1.3
—
—
nmol/l
—
0
0
10
105
0.95
0.00
1.0
1.4
—
—
—
0
0
28
285
0.98
0.00
1.0
1.1
4.55
5.20
u/ml
0.06
12
109
10
96
1.04
0.00
1.0
1.3
—
—
—
0
0
14
144
0.97
0.00
1.1
1.1
—
—
—
0
0
18
176
1.02
0.00
1.4
1.5
—
—
—
0
0
80
799
1.00
0.00
2.9
2.2
—
—
—
0
0
11
107
1.03
0.00
2.0
2.2
—
—
—
0
0
11
107
1.03
0.00
1.1
1.1
—
—
—
0
0
11
113
0.97
0.00
1.5
1.6
5.78
6.44
mmol/l
—
6
81
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
0.00
0.0
2.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
180.86
—
0
7
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0
6
60
1.00
-0.00
1.8
2.2
11.20
9.32
mg/l
—
6
50
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
8
81
0.99
-0.00
1.1
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
1.04
—
0
5
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
6
0.00
-0.00
0.0
8.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
8
80
1.00
-0.00
1.1
1.2
7.35
6.48
mmol/l
—
8
72
5
55
0.91
-0.00
1.8
1.7
—
—
—
0
0
5
55
0.91
-0.00
1.0
1.5
—
—
—
0
0
8
85
0.94
-0.00
1.3
1.2
—
—
—
0
0
0
7
0.00
-0.00
0.0
2.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint H7_OPTNEURITIS and mortality.

Females

Parameter HR [95% CI] p-value
H7_OPTNEURITIS 1.515 [1.3, 1.76] < 0.001
Birth year 0.997 [0.99, 1.01] 0.525

During the follow-up period (1.1.1998 — 31.12.2019), 352 out of 4881 females with H7_OPTNEURITIS died.

Males

Parameter HR [95% CI] p-value
H7_OPTNEURITIS 1.457 [1.25, 1.69] < 0.001
Birth year 0.988 [0.98, 1.0] 0.009

During the follow-up period (1.1.1998 — 31.12.2019), 331 out of 2288 males with H7_OPTNEURITIS died.

Mortality risk

Mortality risk for people of age

years, who have H7_OPTNEURITIS.

N-year risk Females Males
1 0.204% 0.266%
5 0.939% 1.733%
10 2.566% 4.544%
15 4.917% 8.48%
20 8.402% 13.804%

Relationships between endpoints

Index endpoint: H7_OPTNEURITIS – Optic neuritis

GWS hits: 1

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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