No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
452 |
4. Check minimum number of eventsNone |
452 |
5. Include endpointsNone |
452 |
6. Filter based on genotype QC (FinnGen only) |
452 |
Control definitions (FinnGen only)
- Control exclude
- H7_OPTNERVE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H47
- Name in latin
- Aliae morbositates papillae/disci nervi optici non specificatae
Similar endpoints
↥List of similar endpoints to
Other disorders of optic disc
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3105 | 1814 | 1282 |
| Only index persons | 2939 | 1737 | 1202 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 41.97 | 39.97 | 44.82 |
| Only index persons | 42.63 | 40.60 | 45.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 452 | 286 | 166 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.07 |
| Median age at first event (years) | 50.80 | 47.88 | 55.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 397
- Matched controls
- 3968
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
323.0
390
*
H47.1
ICD-10 Finland
Papilloedema, unspecified
+∞
78.8
73
*
XCK00
NOMESCO Finland
Perimetry
15.7
68.9
119
105
XCK10
NOMESCO Finland
Photography of fundus of eye
9.6
52.0
116
164
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
8.7
43.5
101
149
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.4
30.8
66
82
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
161.8
29.1
30
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
28.5
122
367
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
10.4
26.5
53
58
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
26.3
25
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.3
25.8
86
197
XCD10
NOMESCO Finland
Electrophysiological examination of eye
14.6
24.3
41
31
H47.2
ICD-10 Finland
Optic atrophy
+∞
20.0
19
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.7
18.6
67
164
G93.2
ICD-10 Finland
Benign intracranial hypertension
+∞
17.8
17
*
TAB00
NOMESCO Finland
Lumbar puncture
7.3
17.7
43
65
H46
ICD-10 Finland
Optic neuritis
+∞
15.7
15
*
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
12.5
15.3
27
23
H53.4
ICD-10 Finland
Visual field defects
14.7
15.2
25
18
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
29.5
13.1
17
6
S01EC01
ATC
acetazolamide; systemic
8.7
11.5
24
29
CS494
NOMESCO Finland
Other visual field testing
10.5
11.1
21
21
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
12.4
10.9
19
16
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
17.2
9.9
15
9
ZXA10
NOMESCO Finland
Bilateral
2.4
9.9
89
420
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
9.3
50
172
R51.80
ICD-10 Finland
Headache
2.5
9.1
79
364
H53.1
ICD-10 Finland
Subjective visual disturbances
3.6
9.0
40
119
3772A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic disk
+∞
8.4
8
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.1
8.2
25
52
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
7.8
151
974
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
6.4
7.6
19
31
Z3231
NOMESCO Finland
Registered nurse
2.0
7.5
117
695
CS2P4
NOMESCO Finland
Optic nerve head imaging
14.6
6.4
10
7
A02BC01
ATC
omeprazole; systemic
1.9
6.3
104
625
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.9
6.3
19
40
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
6.3
33
114
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.7
6.1
16
29
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTICDISCOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.21 [0.93, 1.57] | 0.153 |
| Birth year | 0.995 [0.99, 1.0] | 0.202 |
During the follow-up period (1.1.1998 — 31.12.2019), 102 out of 1503 females with H7_OPTICDISCOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.083 [0.84, 1.4] | 0.538 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 1051 males with H7_OPTICDISCOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTICDISCOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.177% |
| 5 | 0.814% | 1.259% |
| 10 | 1.812% | 3.309% |
| 15 | 3.528% | 5.975% |
| 20 | 6.072% | 9.793% |
Relationships between endpoints
↥Index endpoint: H7_OPTICDISCOTH – Other disorders of optic disc
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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