No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
510 |
4. Check minimum number of eventsNone |
510 |
5. Include endpointsNone |
510 |
6. Filter based on genotype QC (FinnGen only) |
492 |
Control definitions (FinnGen only)
- Control exclude
- H7_OPTNERVE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H47
- Name in latin
- Aliae morbositates papillae/disci nervi optici non specificatae
Similar endpoints
↥List of similar endpoints to
Other disorders of optic disc
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3105 | 1814 | 1282 |
| Only index persons | 2939 | 1737 | 1202 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 41.97 | 39.97 | 44.82 |
| Only index persons | 42.63 | 40.60 | 45.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 492 | 311 | 181 |
| Unadjusted period prevalence (%) | 0.10 | 0.11 | 0.08 |
| Median age at first event (years) | 52.27 | 49.46 | 57.08 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 510
- Matched controls
- 5100
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.3
ICD-10 Finland
Other disorders of optic disc
4503599627370496.0
307.7
503
*
XCK00
NOMESCO Finland
Perimetry
16.1
138.1
131
107
H47.1
ICD-10 Finland
Papilloedema, unspecified
1102.5
96.2
91
*
XCK10
NOMESCO Finland
Photography of fundus of eye
7.4
75.9
131
229
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.2
74.9
101
133
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
7.4
74.5
127
219
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
11.5
61.2
67
66
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.2
46.6
169
544
XCD10
NOMESCO Finland
Electrophysiological examination of eye
12.9
46.0
46
39
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.3
44.4
104
237
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
12.7
39.9
40
34
H53.4
ICD-10 Finland
Visual field defects
12.0
37.5
39
35
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
34.8
33
*
CS494
NOMESCO Finland
Other visual field testing
9.5
31.1
38
43
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
70.3
29.3
33
5
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
11.7
28.7
30
27
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
8.3
28.0
38
49
H47.2
ICD-10 Finland
Optic atrophy
+∞
27.3
26
*
Z3229
NOMESCO Finland
Other healthcare associate professional
4.2
26.2
76
202
S01EC01
ATC
acetazolamide; systemic
8.7
21.6
28
34
H53.1
ICD-10 Finland
Subjective visual disturbances
4.0
20.4
62
170
TAB00
NOMESCO Finland
Lumbar puncture
4.6
20.0
50
118
H46
ICD-10 Finland
Optic neuritis
+∞
19.9
19
*
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.4
17.9
69
222
G93.2
ICD-10 Finland
Benign intracranial hypertension
98.5
17.7
19
*
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
21.8
16.1
23
11
CS1H4
NOMESCO Finland
Retinal nerve fibre layer imaging
5.3
10.9
22
43
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.0
10.6
31
82
Z3231
NOMESCO Finland
Registered nurse
2.0
10.5
154
916
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
10.2
212
1412
ZXA10
NOMESCO Finland
Bilateral
2.2
10.1
104
542
CS2P4
NOMESCO Finland
Optic nerve head imaging
12.5
9.9
17
14
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
4.0
9.8
28
73
R51.80
ICD-10 Finland
Headache
2.1
9.7
104
551
CK2P4
NOMESCO Finland
Optic nerve head light layer imaging (OCT)
56.1
9.7
11
*
L04AX01
ATC
azathioprine; systemic
3.9
9.2
27
72
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
9.7
8.8
17
18
3772A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic disk
+∞
8.4
8
*
CA1CG
NOMESCO Finland
Eye and orbita extensive MRI examination with high intensity magnet
15.3
7.7
12
8
H43.8
ICD-10 Finland
Other disorders of vitreous body
2.4
7.5
55
248
WX402
NOMESCO Finland
General anaesthesia
1.9
7.4
114
680
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
4.6
7.2
17
38
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
7.0
109
653
CJB10
NOMESCO Finland
Laser discission of secondary cataract
2.6
6.4
37
149
Z2221
NOMESCO Finland
Medical doctor
1.7
6.4
141
932
H02AB06
ATC
prednisolone; systemic
1.6
6.4
221
1639
E04.2
ICD-10 Finland
Nontoxic multinodular goitre
3.4
6.3
22
66
AA1AD
NOMESCO Finland
CT of head and brain
1.8
6.3
120
760
H54.2
ICD-10 Finland
Moderate visual impairment, binocular
18.3
6.3
9
5
J45
ICD-10 Finland
Asthma
2.1
6.1
56
277
H57.1
ICD-10 Finland
Ocular pain
2.9
6.0
27
95
NA1BG
NOMESCO Finland
Cervical spine MRI examination with high intensity magnet
2.7
6.0
31
118
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
25
31
8.43
18.91
1.2
1.0
—
—
—
0
0
42
97
4.63
17.19
1.4
1.2
29.43
132.44
e6/l
0.93
30
81
42
97
4.63
17.19
1.4
1.1
19.93
8.77
e6/l
0.29
30
78
26
44
6.17
14.93
1.1
1.0
—
—
—
0
0
251
1621
2.08
14.59
6.1
4.4
36.56
36.28
g/l
0.36
236
1517
26
52
5.21
12.55
1.1
1.1
—
—
—
0
0
24
50
4.99
11.06
1.1
1.1
—
—
—
0
0
267
1919
1.82
9.96
9.8
6.7
1.22
1.22
mmol/l
0.05
232
1640
250
1762
1.82
9.95
9.0
6.3
1.21
1.22
mmol/l
0.37
234
1609
313
2372
1.83
9.70
6.0
4.8
6.57
6.57
mmol/l
0.01
287
2186
20
24
8.63
9.64
1.2
1.0
0.95
1.08
u/l
—
8
14
45
168
2.84
9.00
2.2
2.2
36.85
39.76
u/l
0.42
39
152
315
2426
1.78
8.89
8.9
8.6
4.21
4.04
e9/l
0.59
263
2125
151
937
1.87
8.87
2.1
1.8
2.28
1.14
mg/l
0.44
117
719
378
3117
1.82
7.99
8.5
7.0
76.15
78.07
u/l
0.40
359
2925
258
1951
1.65
7.15
3.8
2.7
118.14
105.05
ug/l
0.42
244
1813
91
515
1.93
6.93
4.3
2.3
23.42
23.50
%
0.01
82
447
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
28
93
3.13
6.88
3.8
3.6
0.35
0.34
u/ml
0.02
16
53
116
715
1.81
6.76
4.8
3.7
583.92
327.50
ng/l
0.21
73
527
472
4267
2.42
6.74
17.5
12.2
24.21
21.82
mg/l
0.69
383
3287
370
3097
1.71
6.68
4.7
3.8
11.68
10.81
mm/h
0.63
349
2846
227
1683
1.63
6.66
2.8
2.3
80.01
74.68
nmol/l
1.66
206
1513
265
2045
1.62
6.57
7.0
5.6
27.38
29.04
%
1.61
249
1928
164
1128
1.67
6.42
4.6
2.8
0.32
0.46
e6/l
0.30
125
841
110
678
1.79
6.38
3.2
2.6
0.77
0.92
e6/l
0.40
66
375
260
2016
1.59
6.18
6.8
5.4
58.11
56.27
%
1.66
244
1899
206
1517
1.60
6.06
2.0
1.9
99.96
94.80
pmol/l
0.67
96
771
104
642
1.78
5.98
3.2
2.7
3.28
2.61
e6/l
0.31
58
343
147
1000
1.66
5.94
2.1
2.1
2.71
3.08
mg/l
1.21
130
853
98
598
1.79
5.85
4.1
2.2
13.61
13.89
umol/l
0.11
93
557
470
4289
2.22
5.74
19.7
13.8
139.68
139.66
mmol/l
0.05
460
4170
471
4303
2.24
5.71
20.0
13.9
3.94
3.95
mmol/l
0.47
460
4173
268
2122
1.55
5.62
4.0
3.4
0.00
0.00
estimate
-0.00
46
399
265
2095
1.55
5.58
5.7
4.6
0.00
0.00
estimate
-0.00
47
419
265
2096
1.55
5.56
4.0
3.4
0.00
0.00
estimate
0.50
49
436
193
1423
1.57
5.53
4.6
2.9
—
—
—
0
0
188
1379
1.58
5.51
3.2
3.2
28.31
30.40
u/l
0.73
178
1308
264
2097
1.54
5.37
5.9
6.0
10.54
11.72
umol/l
1.07
250
1974
29
115
2.61
5.22
1.3
1.6
0.00
0.04
iu/ml
—
6
22
12
19
6.44
5.10
4.1
3.4
2389.42
761.53
u/ml
0.38
12
19
180
1326
1.55
5.09
3.3
3.0
2.35
2.36
mmol/l
0.07
165
1176
69
401
1.83
4.81
9.0
9.4
0.76
1.15
mmol/l
0.43
51
329
248
1979
1.49
4.72
2.7
2.5
—
—
—
0
0
69
405
1.81
4.66
9.1
9.3
12.92
12.74
kpa
0.10
63
394
69
405
1.81
4.66
9.1
9.3
4.99
5.09
kpa
0.48
63
393
71
421
1.80
4.63
1.8
1.8
—
—
—
0
0
122
838
1.60
4.61
3.8
2.4
4.38
6.30
e6/l
0.71
107
747
167
1235
1.52
4.55
4.6
2.9
69.09
102.57
e6/l
0.22
128
942
423
3800
1.66
4.49
22.4
14.8
14.70
14.68
%
0.03
418
3744
60
342
1.85
4.45
7.2
4.0
1.33
1.72
mmol/l
0.44
49
276
436
3957
1.70
4.33
5.3
4.6
1.83
2.17
mu/l
0.58
401
3645
7
6
11.80
4.28
1.0
1.0
—
—
—
0
0
64
377
1.80
4.27
2.0
2.3
30.34
30.98
u/l
0.07
56
313
18
62
2.97
4.21
1.1
1.1
—
—
—
0
0
68
414
1.74
4.06
1.9
1.8
—
—
—
0
0
155
1153
1.49
4.03
1.8
2.0
352.60
252.50
u/l
0.18
149
1084
216
1717
1.45
3.99
19.1
11.1
1.26
1.20
inr
0.43
62
531
136
987
1.52
3.98
3.3
3.1
1823.84
1076.61
ng/l
0.77
109
825
10
19
5.35
3.84
1.8
1.3
—
—
—
0
0
50
284
1.84
3.76
1.7
2.7
65.43
67.27
g/l
0.88
44
260
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
12
29
4.21
3.72
1.0
1.2
—
—
—
0
0
133
973
1.50
3.72
2.3
2.1
—
—
—
0
0
29
137
2.18
3.62
1.4
2.5
—
—
—
0
0
22
92
2.45
3.61
1.4
1.4
288.53
241.59
u/ml
0.33
15
51
36
195
1.91
3.15
1.7
1.7
—
—
—
0
0
135
1022
1.44
3.12
2.7
2.6
331.71
6487.20
umol/l
3.93
118
896
10
25
4.06
3.10
1.0
1.2
—
—
—
0
0
142
1087
1.42
3.08
1.5
1.3
1.98
1.74
u/ml
0.07
34
284
118
879
1.45
2.96
1.6
1.5
22.62
21.03
nmol/l
0.18
104
753
427
3947
1.50
2.91
16.5
11.3
84.61
86.11
ml/min/173m2
0.57
343
3188
44
261
1.75
2.91
2.1
1.5
—
—
—
0
0
28
143
2.01
2.91
2.0
1.3
—
—
—
0
0
477
4528
1.83
2.89
12.4
9.4
24.81
25.88
u/l
0.81
470
4360
17
71
2.44
2.83
3.8
2.4
16.25
16.37
%
0.03
11
31
19
84
2.31
2.80
1.5
1.8
5.97
4.89
mmol/24h
0.71
19
73
8
18
4.50
2.80
1.0
1.1
—
—
—
0
0
144
1122
1.39
2.80
4.9
3.9
20.55
9.40
mg/mmol
0.88
90
702
38
219
1.79
2.77
1.4
1.4
22.69
21.31
iu/l
0.09
31
185
327
2898
1.36
2.76
3.0
3.1
43.03
43.42
u/l
0.04
314
2729
5
6
8.40
2.75
1.2
6.5
—
—
—
0
0
154
1223
1.37
2.65
3.9
3.2
7.74
7.69
mmol/l
0.04
135
1047
175
1420
1.35
2.62
3.3
3.4
79.69
59.80
ng/l
0.14
111
901
7
15
4.72
2.60
1.0
1.1
—
—
—
0
0
408
3762
1.42
2.60
6.3
5.4
40.40
39.16
mmol/mol
1.46
384
3526
83
592
1.48
2.59
1.9
1.9
—
—
—
0
0
20
94
2.17
2.58
1.8
1.4
—
—
—
0
0
366
3326
1.36
2.46
4.4
3.9
14.77
14.60
pmol/l
0.76
332
3024
20
96
2.13
2.46
1.6
1.5
—
—
—
0
0
10
32
3.17
2.44
2.5
1.5
—
—
—
0
0
18
83
2.21
2.44
8.7
5.4
345.40
257.44
iu/ml
—
5
9
20
98
2.08
2.34
1.4
1.3
—
—
—
0
0
89
657
1.43
2.33
1.8
1.6
1166.34
1180.83
nmol/l
0.05
65
493
66
460
1.50
2.31
2.0
2.9
5.59
8.22
umol/l
0.77
55
392
18
85
2.16
2.31
1.8
1.6
—
—
—
0
0
16
72
2.26
2.30
2.9
3.4
4.76
4.38
e9/l
0.15
16
72
6
13
4.66
2.27
1.0
1.2
—
—
—
0
0
6
13
4.66
2.27
1.0
1.3
—
—
—
0
0
498
4831
2.31
2.26
25.2
18.0
4.50
4.52
e12/l
0.43
483
4695
14
60
2.37
2.23
2.1
1.4
—
—
—
0
0
336
3037
1.31
2.21
3.4
3.4
—
—
—
0
0
39
243
1.66
2.20
4.2
3.1
138.87
156.85
ng/l
0.11
31
219
154
1256
1.32
2.17
2.6
2.5
57.33
60.72
u/l
0.26
147
1162
16
74
2.20
2.17
4.3
3.8
58.38
57.53
%
0.08
16
74
9
30
3.04
2.15
1.7
1.2
1.76
1.90
mmol/l
—
9
30
126
1000
1.35
2.14
1.8
1.6
—
—
—
0
0
101
775
1.38
2.12
1.8
1.7
433.86
8649902.37
pmol/l
0.50
81
659
497
4826
2.17
2.10
25.4
18.1
256.80
254.21
e9/l
0.40
483
4699
11
43
2.59
2.09
3.3
2.2
—
—
—
0
0
91
689
1.39
2.07
2.6
2.6
2.44
2.44
mmol/l
0.19
76
599
497
4829
2.15
2.04
25.7
18.2
40.22
41.34
%
0.57
466
4559
59
413
1.48
2.04
2.3
1.8
378.87
374.87
nmol/l
0.05
54
377
9
32
2.84
2.01
1.7
1.6
—
—
—
0
0
20
105
1.94
1.98
3.5
4.1
33.23
32.01
mg/l
0.05
14
85
20
105
1.94
1.98
3.4
4.1
26.28
108.33
mg/l
0.76
14
86
15
71
2.15
1.94
1.3
1.2
—
—
—
0
0
15
71
2.15
1.94
1.3
1.2
—
—
—
0
0
7
22
3.21
1.88
2.1
1.6
—
—
—
0
0
60
431
1.44
1.84
2.0
1.9
—
—
—
0
0
5
12
4.20
1.82
1.0
1.2
—
—
—
0
0
5
12
4.20
1.82
1.0
1.1
—
—
—
0
0
62
450
1.43
1.80
9.6
6.5
105.39
104.16
mmol/l
1.53
62
450
43
290
1.53
1.79
1.5
1.2
641.41
278.82
u/ml
0.51
38
264
11
47
2.37
1.79
2.5
1.4
—
—
—
0
0
14
67
2.12
1.77
1.5
1.2
1.89
3.87
u/ml
—
9
30
12
54
2.25
1.75
1.4
1.2
—
—
—
0
0
19
103
1.88
1.74
1.6
1.8
5.43
5.22
iu/l
—
6
32
5
13
3.87
1.72
1.0
1.2
—
—
—
0
0
5
13
3.87
1.72
10.2
6.9
—
—
—
0
0
44
303
1.49
1.67
6.0
3.2
4.87
4.64
kpa
0.29
44
296
6
19
3.18
1.66
2.3
1.6
—
—
—
0
0
7
25
2.82
1.65
1.1
1.1
—
—
—
0
0
43
296
1.49
1.64
11.4
3.4
1.22
1.23
mmol/l
0.42
36
258
439
4181
1.36
1.62
5.1
4.6
2.72
2.80
mmol/l
1.14
413
3872
6
20
3.02
1.58
2.3
1.5
—
—
—
0
0
6
20
3.02
1.58
1.0
1.0
—
—
—
0
0
13
64
2.06
1.55
1.2
1.1
—
—
—
0
0
0
43
0.00
1.53
0.0
1.4
—
—
—
0
0
132
1102
1.27
1.52
1.7
1.6
1.37
1.39
mmol/l
0.08
112
939
26
163
1.63
1.49
1.5
1.7
—
—
—
0
0
33
221
1.53
1.45
1.4
1.3
—
—
—
0
0
432
4120
1.32
1.45
4.7
4.2
4.64
4.70
mmol/l
0.56
412
3846
17
95
1.82
1.44
1.3
1.4
—
—
—
0
0
94
758
1.29
1.42
1.4
1.3
17.11
33.38
iu/ml
1.92
28
241
15
81
1.88
1.41
1.4
1.5
7462.67
17905.52
e6/l
—
9
62
14
74
1.92
1.40
2.5
1.6
—
—
—
0
0
17
98
1.76
1.32
1.4
1.2
3.40
3.78
u/ml
—
9
59
10
48
2.10
1.28
1.3
1.8
—
—
—
0
0
19
115
1.68
1.26
1.4
1.1
—
—
—
0
0
425
4063
1.28
1.26
4.6
4.2
5.91
5.86
mmol/l
0.34
387
3723
12
63
1.93
1.23
9.8
3.6
369.00
3918.14
u/ml
—
5
7
26
172
1.54
1.23
4.4
2.6
0.75
0.66
%
0.77
26
172
5
19
2.65
1.22
2.2
1.4
11.00
12.79
u/l
—
5
19
34
239
1.45
1.22
2.5
2.2
4771.46
4670.64
u/l
0.01
13
100
54
415
1.34
1.17
3.9
3.1
—
—
—
0
0
428
4106
1.26
1.15
4.5
4.1
1.47
1.48
mmol/l
0.05
401
3813
0
36
0.00
1.14
0.0
3.1
—
43.91
—
0
36
36
260
1.41
1.13
4.5
5.1
0.98
1.75
mmol/l
0.80
28
192
7
32
2.20
1.08
1.3
1.2
—
—
—
0
0
45
341
1.35
1.07
1.7
1.8
—
—
—
0
0
13
74
1.78
1.07
1.3
1.4
—
—
—
0
0
10
52
1.94
1.07
1.0
1.1
1.56
1.41
g/l
—
10
47
7
33
2.14
1.06
1.1
1.2
—
—
—
0
0
7
34
2.07
1.03
1.3
1.1
—
—
—
0
0
25
172
1.48
1.02
1.8
1.6
—
—
—
0
0
12
68
1.78
1.01
1.6
1.2
3.80
2.27
u/ml
—
5
26
88
736
1.24
1.01
1.4
1.3
5.34
12.18
u/ml
1.27
32
289
5
23
2.19
0.98
1.2
1.3
1.49
1.52
g/l
—
5
23
40
304
1.34
0.95
2.2
2.4
58.22
70.30
ml/min/173m2
0.96
18
125
17
110
1.56
0.91
1.7
1.4
—
—
—
0
0
6
29
2.08
0.89
4.7
1.9
—
—
—
0
0
46
361
1.30
0.89
4.1
4.2
2.58
36.78
ug/l
0.91
36
299
16
103
1.57
0.88
2.3
1.6
—
—
—
0
0
8
44
1.83
0.86
1.3
1.9
—
—
—
0
0
15
96
1.58
0.85
1.7
1.1
—
—
—
0
0
411
3961
1.19
0.84
4.1
3.8
1.28
1.28
mmol/l
0.03
383
3663
8
47
1.71
0.81
1.3
1.3
—
—
—
0
0
16
106
1.53
0.79
2.1
1.6
—
—
—
0
0
0
24
0.00
0.79
0.0
1.9
—
1.18
—
0
18
6
33
1.83
0.79
1.0
1.5
199.88
170.86
pmol/l
—
6
33
179
1636
1.15
0.74
4.5
3.4
—
—
—
0
0
11
68
1.63
0.72
1.3
1.1
—
12.90
—
0
5
7
40
1.76
0.71
1.1
1.1
—
—
—
0
0
9
57
1.59
0.71
1.3
1.1
—
—
—
0
0
5
26
1.93
0.71
1.4
3.0
—
—
—
0
0
7
41
1.72
0.70
1.1
1.1
—
—
—
0
0
7
42
1.68
0.68
1.0
1.2
—
—
—
0
0
7
42
1.68
0.68
1.0
1.2
—
—
—
0
0
42
340
1.26
0.67
1.3
1.2
112.81
165.04
iu/ml
0.68
14
141
7
43
1.64
0.67
1.0
1.2
—
—
—
0
0
7
43
1.64
0.67
1.0
1.2
—
—
—
0
0
7
43
1.64
0.67
1.0
1.2
—
—
—
0
0
5
28
1.79
0.66
1.4
1.2
—
—
—
0
0
5
28
1.79
0.66
1.2
1.4
1.08
1.05
g/l
—
5
28
11
70
1.58
0.65
1.3
1.1
—
—
—
0
0
14
97
1.46
0.59
1.9
1.4
—
—
—
0
0
8
55
1.46
0.56
2.0
1.7
—
—
—
0
0
116
1052
1.13
0.54
5.0
4.6
1.67
2.32
ug/l
0.86
108
940
11
74
1.50
0.53
1.5
1.9
—
—
—
0
0
13
181
0.71
0.53
1.2
1.8
—
—
—
0
0
6
39
1.54
0.53
2.8
3.7
—
—
—
0
0
6
41
1.47
0.50
1.0
1.2
—
—
—
0
0
42
495
0.83
0.50
4.3
4.1
31.91
31.59
%
0.06
33
339
12
167
0.71
0.50
1.4
1.4
—
—
—
0
0
5
82
0.61
0.46
1.4
1.2
—
—
—
0
0
121
1113
1.11
0.45
4.8
3.6
0.00
0.00
estimate
-0.00
46
410
15
112
1.35
0.45
3.2
2.4
—
—
—
0
0
8
56
1.44
0.42
2.0
1.6
—
—
—
0
0
6
93
0.64
0.42
1.0
1.2
—
—
—
0
0
5
32
1.57
0.42
1.8
1.2
—
—
—
0
0
0
15
0.00
0.41
0.0
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
3.3
—
—
—
0
0
0
15
0.00
0.41
0.0
3.3
—
—
—
0
0
0
16
0.00
0.41
0.0
1.2
—
8.08
—
0
16
92
840
1.12
0.40
4.3
4.2
23.92
21.15
%
0.91
34
380
5
35
1.43
0.39
1.4
1.7
16.89
16.78
ug/l
—
5
35
0
19
0.00
0.39
0.0
1.1
—
—
—
0
0
17
134
1.28
0.37
1.0
1.1
—
—
—
0
0
17
135
1.27
0.35
1.0
1.1
—
—
—
0
0
6
45
1.34
0.34
1.5
2.3
—
19.27
—
0
16
42
474
0.88
0.32
5.2
5.9
—
—
—
0
0
8
66
1.22
0.27
2.0
1.6
—
—
—
0
0
27
235
1.16
0.26
3.3
2.5
49.38
43.09
u/ml
0.10
27
224
11
137
0.80
0.24
1.5
1.8
—
—
—
0
0
87
816
1.08
0.24
1.5
1.4
—
—
—
0
0
5
40
1.25
0.22
1.4
1.2
0.86
1.63
nmol/l
—
5
35
5
41
1.22
0.22
1.4
2.0
12.80
13.39
%
—
5
41
13
156
0.83
0.21
1.8
1.7
—
—
—
0
0
8
101
0.79
0.21
1.1
1.2
—
—
—
0
0
0
13
0.00
0.21
0.0
1.2
—
—
—
0
0
6
48
1.25
0.20
5.7
2.5
106.33
105.42
mmol/l
—
6
48
0
14
0.00
0.20
0.0
1.2
—
2.40
—
0
9
45
414
1.10
0.19
2.2
1.6
—
—
—
0
0
6
51
1.18
0.19
1.0
1.0
—
—
—
0
0
6
53
1.13
0.18
1.0
1.5
—
—
—
0
0
6
53
1.13
0.18
1.0
1.5
—
—
—
0
0
64
680
0.93
0.18
2.2
2.0
—
—
—
0
0
12
141
0.85
0.16
1.5
2.0
—
—
—
0
0
21
187
1.13
0.16
1.5
1.5
—
—
—
0
0
17
149
1.15
0.16
1.8
2.2
—
—
—
0
0
8
73
1.10
0.15
2.0
1.6
—
—
—
0
0
20
178
1.13
0.15
1.5
1.3
324.50
269.68
miu/ml
—
6
90
11
93
1.19
0.14
1.7
1.7
—
—
—
0
0
8
98
0.81
0.14
1.1
1.2
—
1.03
—
0
8
19
171
1.12
0.12
1.4
1.6
—
—
—
0
0
20
220
0.91
0.12
1.4
1.4
—
—
—
0
0
28
259
1.09
0.12
1.0
1.0
—
—
—
0
0
5
61
0.82
0.08
1.0
1.1
38.64
22.52
u/l
—
5
53
14
154
0.91
0.08
1.4
1.5
—
—
—
0
0
72
743
0.96
0.08
2.3
2.2
—
—
—
0
0
7
66
1.06
0.08
1.1
1.5
6.33
7.54
mmol/l
—
7
55
35
333
1.05
0.07
1.4
1.5
—
—
—
0
0
8
78
1.03
0.07
1.4
1.3
—
—
—
0
0
56
579
0.96
0.07
1.4
1.8
1.53
1.45
%
0.40
48
518
30
285
1.06
0.06
1.2
1.3
—
—
—
0
0
97
950
1.03
0.06
3.6
3.4
1.02
1.02
kg/l
0.20
16
137
18
169
1.07
0.05
1.4
1.4
—
—
—
0
0
18
169
1.07
0.05
1.4
1.4
—
—
—
0
0
18
170
1.06
0.04
1.4
1.4
—
—
—
0
0
18
170
1.06
0.04
1.4
1.4
—
—
—
0
0
62
610
1.02
0.02
3.3
2.9
0.72
0.76
ug/l
0.15
41
386
13
123
1.06
0.01
1.4
1.3
182.57
309.81
ug/g
—
7
67
13
129
1.01
0.00
1.2
1.5
—
—
—
0
0
5
56
0.89
0.00
2.8
1.4
—
—
—
0
0
5
56
0.89
0.00
2.8
1.4
—
—
—
0
0
5
51
0.98
0.00
1.8
1.3
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.9
—
1.21
—
0
9
5
57
0.88
-0.00
2.8
1.4
—
—
—
0
0
5
57
0.88
-0.00
2.8
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
2.8
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
57
0.88
-0.00
2.8
1.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.7
—
40.00
—
0
6
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.4
—
57.54
—
0
5
7
74
0.95
-0.00
1.3
1.7
—
—
—
0
0
7
74
0.95
-0.00
1.3
1.7
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.7
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTICDISCOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.21 [0.93, 1.57] | 0.153 |
| Birth year | 0.995 [0.99, 1.0] | 0.202 |
During the follow-up period (1.1.1998 — 31.12.2019), 102 out of 1503 females with H7_OPTICDISCOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.083 [0.84, 1.4] | 0.538 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 1051 males with H7_OPTICDISCOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTICDISCOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.177% |
| 5 | 0.814% | 1.259% |
| 10 | 1.812% | 3.309% |
| 15 | 3.528% | 5.975% |
| 20 | 6.072% | 9.793% |
Relationships between endpoints
↥Index endpoint: H7_OPTICDISCOTH – Other disorders of optic disc
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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