No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
452 |
4. Check minimum number of eventsNone |
452 |
5. Include endpointsNone |
452 |
6. Filter based on genotype QC (FinnGen only) |
452 |
Control definitions (FinnGen only)
- Control exclude
- H7_OPTNERVE
Extra metadata
- Level in the ICD hierarchy
- 4
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H47
- Name in latin
- Aliae morbositates papillae/disci nervi optici non specificatae
Similar endpoints
↥List of similar endpoints to
Other disorders of optic disc
based on the number of shared cases.
Similar with more cases:
- Other disorders of optic [2nd] nerve and visual pathways
- Disorders of optic nerve and visual pathways
- Diseases of the eye and adnexa
- Any event in hilmo or specialist outpatient
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 3105 | 1814 | 1282 |
| Only index persons | 2939 | 1737 | 1202 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.05 | 0.05 | 0.04 |
| Only index persons | 0.06 | 0.06 | 0.05 |
| Median age at first event (years) | |||
| Whole population | 41.97 | 39.97 | 44.82 |
| Only index persons | 42.63 | 40.60 | 45.56 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 452 | 286 | 166 |
| Unadjusted period prevalence (%) | 0.09 | 0.10 | 0.07 |
| Median age at first event (years) | 50.80 | 47.88 | 55.82 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
No data
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 397
- Matched controls
- 3968
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H47.3
ICD-10 Finland
Other disorders of optic disc
+∞
323.0
390
*
H47.1
ICD-10 Finland
Papilloedema, unspecified
+∞
78.8
73
*
XCK00
NOMESCO Finland
Perimetry
15.7
68.9
119
105
XCK10
NOMESCO Finland
Photography of fundus of eye
9.6
52.0
116
164
CK2X4
NOMESCO Finland
Optical coherence tomography (OCT) of ocular fundus
8.7
43.5
101
149
CK2S4
NOMESCO Finland
Plain photography of ocular fundus
9.4
30.8
66
82
CK2A4
NOMESCO Finland
Autofluorescence imaging of ocular fundus
161.8
29.1
30
*
Z01.0
ICD-10 Finland
Examination of eyes and vision
4.4
28.5
122
367
CS444
NOMESCO Finland
Visual field testing with Octopus automated perimetry
10.4
26.5
53
58
H47.0
ICD-10 Finland
Disorders of optic nerve, not elsewhere classified
+∞
26.3
25
*
XCW99
NOMESCO Finland
Other investigative procedure of eye
5.3
25.8
86
197
XCD10
NOMESCO Finland
Electrophysiological examination of eye
14.6
24.3
41
31
H47.2
ICD-10 Finland
Optic atrophy
+∞
20.0
19
*
G93.2
ICD-10 Finland
Benign intracranial hypertension
+∞
17.8
17
*
TAB00
NOMESCO Finland
Lumbar puncture
7.3
17.7
43
65
H46
ICD-10 Finland
Optic neuritis
+∞
15.7
15
*
CS5Z4
NOMESCO Finland
Specialised imaging for glaucoma
12.5
15.3
27
23
H53.4
ICD-10 Finland
Visual field defects
14.7
15.2
25
18
CS424
NOMESCO Finland
Visual field testing with Goldmann perimetry
29.5
13.1
17
6
S01EC01
ATC
acetazolamide; systemic
8.7
11.5
24
29
CS494
NOMESCO Finland
Other visual field testing
10.5
11.1
21
21
CS434
NOMESCO Finland
Visual field testing with Humphrey automated perimetry
12.4
10.9
19
16
CS3P4
NOMESCO Finland
Optic nerve head stereophotography
17.2
9.9
15
9
ZXA10
NOMESCO Finland
Bilateral
2.4
9.9
89
420
AA1CG
NOMESCO Finland
Extensive MRI examination of brain with high intensity magnet
3.2
9.3
50
172
R51.80
ICD-10 Finland
Headache
2.5
9.1
79
364
H53.1
ICD-10 Finland
Subjective visual disturbances
3.6
9.0
40
119
3772A
ICD-9 Finland
Disorders of optic nerve and visual pathways, Other disorders of optic disk
+∞
8.4
8
*
AA1DG
NOMESCO Finland
Very extensive MRI examination of brain with high intensity magnet
5.1
8.2
25
52
S01XA20
ATC
artificial tears and other indifferent preparations; ophthalmic
1.9
7.8
151
974
H35.38
ICD-10 Finland
Preretinal fibrosis of the macula
6.4
7.6
19
31
CS2P4
NOMESCO Finland
Optic nerve head imaging
14.6
6.4
10
7
A02BC01
ATC
omeprazole; systemic
1.9
6.3
104
625
H53.9
ICD-10 Finland
Visual disturbance, unspecified
4.9
6.3
19
40
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.1
6.3
33
114
AA1CM
NOMESCO Finland
Extensive MRI examination of brain with 3 Tesla magnet
5.7
6.1
16
29
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
23
30
8.02
16.70
1.2
1.0
—
—
—
0
0
24
41
6.13
13.66
1.1
1.0
—
—
—
0
0
36
91
4.21
13.16
1.3
1.1
21.4
9.3
e6/l
0.29
27
73
36
91
4.21
13.16
1.3
1.2
32.4
135.4
e6/l
0.85
27
76
219
1431
2.03
12.15
5.6
4.5
36.7
36.4
g/l
0.36
207
1337
24
47
5.34
11.86
1.1
1.1
—
—
—
0
0
17
24
7.32
11.49
1.2
1.0
1.0
1.1
u/l
—
7
13
24
49
5.12
11.33
1.1
1.1
—
—
—
0
0
236
1698
1.82
8.81
8.9
6.7
1.2
1.2
mmol/l
0.08
203
1436
221
1562
1.81
8.73
8.6
6.4
1.2
1.2
mmol/l
0.35
206
1423
277
2158
1.73
7.28
8.8
8.6
4.2
4.1
e9/l
0.51
232
1893
272
2110
1.73
7.24
6.4
4.9
6.5
6.5
mmol/l
0.03
250
1945
131
830
1.81
7.15
2.2
1.7
2.6
1.1
mg/l
0.50
101
633
39
153
2.70
7.15
2.3
2.2
35.8
40.2
u/l
0.73
33
139
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
26
81
3.34
7.08
4.0
3.6
0.3
0.3
u/ml
0.15
15
49
333
2749
1.80
6.98
8.3
7.1
75.3
77.7
u/l
0.51
317
2580
327
2733
1.71
6.02
4.5
3.8
11.4
10.8
mm/h
0.40
308
2512
227
1733
1.62
5.97
3.8
2.8
118.5
103.2
ug/l
0.45
215
1609
418
3782
2.40
5.93
16.8
12.3
23.8
21.7
mg/l
0.54
337
2909
131
873
1.70
5.84
2.2
2.1
2.7
3.0
mg/l
0.87
115
745
11
20
5.61
5.83
4.4
3.3
2573.0
738.3
u/ml
0.40
11
20
101
630
1.78
5.68
5.1
3.8
696.3
362.7
ng/l
0.23
61
458
77
449
1.86
5.37
3.8
2.3
21.2
23.7
%
1.12
68
388
198
1495
1.58
5.25
2.6
2.2
80.4
74.7
nmol/l
1.61
181
1345
143
1005
1.62
5.10
3.9
2.8
0.4
0.5
e6/l
0.19
110
743
95
602
1.73
5.01
3.2
2.6
0.8
0.9
e6/l
0.38
57
334
172
1271
1.57
4.93
4.0
3.0
—
—
—
0
0
90
565
1.74
4.90
3.2
2.7
3.7
2.7
e6/l
0.39
50
302
179
1339
1.56
4.84
1.9
1.8
100.3
94.6
pmol/l
0.73
83
681
160
1169
1.57
4.79
3.2
3.0
2.3
2.4
mmol/l
0.30
149
1033
414
3793
2.09
4.66
19.2
14.0
4.0
4.0
mmol/l
0.15
403
3676
413
3782
2.07
4.63
19.0
13.9
139.7
139.7
mmol/l
0.02
403
3676
63
363
1.85
4.55
1.7
1.8
—
—
—
0
0
55
306
1.91
4.43
5.9
4.2
1.2
1.7
mmol/l
0.54
43
240
231
1854
1.50
4.37
3.6
3.4
0.0
0.0
estimate
0.00
41
365
164
1229
1.52
4.29
3.2
3.2
27.9
30.8
u/l
1.18
154
1167
231
1859
1.50
4.29
5.2
4.6
0.0
0.0
estimate
0.00
42
368
233
1881
1.49
4.24
3.6
3.4
0.0
0.0
estimate
0.00
42
353
21
79
2.74
4.22
1.3
1.4
300.6
227.2
u/ml
0.54
14
43
25
103
2.51
4.21
1.4
1.6
0.0
0.0
iu/ml
—
6
21
(3016894) Varicella zoster virus DNA [Presence] in Cerebral spinal fluid by NAA with probe detection
11
27
4.15
4.18
1.0
1.1
—
—
—
0
0
61
359
1.81
4.12
9.9
9.3
0.6
1.2
mmol/l
0.78
44
296
61
362
1.79
4.01
9.9
9.1
12.5
12.8
kpa
0.16
55
354
61
362
1.79
4.01
9.9
9.1
5.0
5.1
kpa
0.33
55
353
60
357
1.78
3.91
1.8
1.8
—
—
—
0
0
228
1853
1.46
3.90
5.8
6.1
10.6
11.9
umol/l
1.04
215
1748
39
202
2.02
3.86
4.2
3.3
138.9
170.3
ng/l
0.19
31
179
138
1017
1.51
3.83
1.9
2.1
128.3
260.8
u/l
1.31
133
955
216
1748
1.45
3.72
4.0
4.1
—
—
—
0
0
6
6
10.11
3.50
1.0
1.0
—
—
—
0
0
9
18
5.08
3.38
1.6
1.3
—
—
—
0
0
16
59
2.77
3.35
1.0
1.1
—
—
—
0
0
385
3530
1.61
3.25
20.1
13.2
39.8
40.2
%
0.38
287
2706
36
195
1.92
3.17
7.5
10.1
24.1
24.7
mmol/l
0.37
31
187
127
954
1.46
3.13
1.4
1.3
2.2
1.8
u/ml
0.08
30
254
160
1255
1.43
3.13
3.2
3.4
84.2
62.4
ng/l
0.13
100
793
381
3499
1.57
3.03
5.4
4.6
1.8
2.2
mu/l
0.61
349
3224
358
3246
1.49
3.01
22.2
15.2
13.7
13.6
%
0.78
352
3187
8
17
4.77
2.93
1.0
1.1
—
—
—
0
0
120
904
1.45
2.89
2.6
2.6
335.3
6210.6
umol/l
3.53
107
784
7
13
5.45
2.88
1.0
1.1
—
—
—
0
0
116
870
1.45
2.86
3.1
3.1
1693.5
1091.8
ng/l
0.48
91
728
54
343
1.65
2.81
2.1
2.2
27.6
30.8
u/l
0.58
49
284
94
680
1.48
2.78
1.8
1.7
397.3
435.8
pmol/l
1.07
75
576
19
85
2.29
2.74
1.4
1.4
—
—
—
0
0
45
275
1.71
2.71
15.4
7.1
10.8
8.6
mmol/l
1.06
45
262
291
2564
1.38
2.70
2.9
3.1
41.2
43.4
u/l
0.25
279
2418
9
24
3.80
2.68
1.0
1.1
—
—
—
0
0
19
86
2.26
2.67
1.7
1.4
—
—
—
0
0
422
4000
1.83
2.66
12.0
9.6
24.6
26.0
u/l
1.31
415
3854
82
582
1.50
2.66
1.8
1.7
1192.7
1182.9
nmol/l
0.03
59
437
24
122
2.02
2.55
1.4
2.2
—
—
—
0
0
6
11
5.51
2.55
1.0
1.3
—
—
—
0
0
6
11
5.51
2.55
1.0
1.2
—
—
—
0
0
31
174
1.84
2.49
1.7
1.7
—
—
—
0
0
101
759
1.43
2.44
1.6
1.5
22.6
21.0
nmol/l
0.15
88
648
17
77
2.25
2.40
1.7
1.6
—
—
—
0
0
9
27
3.38
2.40
1.4
1.6
—
—
—
0
0
113
869
1.40
2.40
2.2
2.2
—
—
—
0
0
73
517
1.49
2.40
1.7
1.9
—
—
—
0
0
13
52
2.54
2.38
1.3
1.5
—
—
—
0
0
139
1111
1.36
2.33
2.6
2.5
58.2
56.0
u/l
0.20
133
1026
9
28
3.26
2.32
1.7
1.2
1.8
1.9
mmol/l
—
9
28
115
894
1.38
2.28
1.7
1.6
—
—
—
0
0
374
3475
1.44
2.27
15.8
11.4
84.8
86.3
ml/min/173m2
0.55
302
2796
58
399
1.52
2.19
1.8
3.0
5.8
8.3
umol/l
0.60
49
343
14
62
2.30
2.09
2.5
2.5
16.9
16.3
%
—
8
26
358
3316
1.38
2.08
6.1
5.4
40.0
39.1
mmol/mol
0.92
336
3112
5
10
5.04
2.07
1.0
1.0
—
—
—
0
0
5
10
5.04
2.07
1.0
1.1
—
—
—
0
0
39
250
1.61
2.00
1.6
2.7
65.2
67.2
g/l
0.77
34
228
5
11
4.58
1.94
1.0
1.1
—
—
—
0
0
23
128
1.84
1.93
2.3
1.3
—
—
—
0
0
321
2941
1.32
1.89
4.5
3.9
14.8
14.6
pmol/l
0.71
293
2672
32
198
1.66
1.89
1.4
1.4
24.9
21.0
iu/l
0.26
27
168
36
230
1.61
1.88
1.6
1.5
—
—
—
0
0
56
397
1.47
1.85
2.0
1.9
—
—
—
0
0
10
40
2.53
1.84
1.4
1.5
—
—
—
0
0
6
17
3.56
1.84
1.0
1.0
—
—
—
0
0
52
364
1.48
1.83
2.1
1.9
374.4
375.0
nmol/l
0.01
47
331
297
2699
1.29
1.82
3.3
3.5
—
—
—
0
0
86
666
1.36
1.74
1.4
1.3
12.8
29.2
iu/ml
3.29
26
199
13
62
2.13
1.67
1.4
1.3
—
—
—
0
0
13
62
2.13
1.67
1.4
1.3
—
—
—
0
0
120
989
1.29
1.57
5.2
4.1
18.8
9.5
mg/mmol
0.62
74
626
78
605
1.35
1.56
2.7
2.6
2.4
2.4
mmol/l
0.19
68
529
13
64
2.06
1.55
2.0
3.6
5.0
4.5
e9/l
0.17
13
64
33
218
1.55
1.54
2.6
2.3
4771.5
3572.0
u/l
0.13
13
93
16
86
1.89
1.52
1.4
1.2
4.5
2.5
u/ml
—
6
38
18
101
1.81
1.51
1.4
1.1
—
—
—
0
0
12
58
2.10
1.50
1.2
1.1
—
—
—
0
0
83
656
1.32
1.47
1.4
1.3
5.8
11.4
u/ml
0.88
29
255
18
102
1.80
1.47
2.4
1.9
110.6
296.6
ug/l
1.98
18
93
13
66
2.00
1.44
2.0
4.0
59.8
58.8
%
0.09
13
66
15
81
1.88
1.41
1.3
1.3
—
—
—
0
0
39
273
1.47
1.41
4.1
3.3
4.9
4.6
kpa
0.36
39
267
7
29
2.44
1.39
1.1
1.2
—
—
—
0
0
0
40
0.00
1.33
0.0
1.4
—
—
—
0
0
17
98
1.76
1.33
1.6
1.9
5.4
5.5
iu/l
—
6
31
385
3680
1.31
1.25
5.1
4.6
2.7
2.8
mmol/l
0.66
361
3406
375
3576
1.29
1.21
4.6
4.2
5.9
5.9
mmol/l
0.04
343
3279
5
20
2.52
1.15
1.4
1.6
—
—
—
0
0
16
95
1.71
1.15
1.7
1.4
—
—
—
0
0
12
65
1.87
1.14
1.3
1.5
—
—
—
0
0
22
143
1.57
1.13
1.6
1.6
—
—
—
0
0
379
3627
1.28
1.13
4.6
4.2
4.7
4.7
mmol/l
0.28
359
3382
7
30
2.35
1.12
2.0
1.7
—
—
—
0
0
15
88
1.73
1.12
1.2
1.6
—
—
—
0
0
12
66
1.84
1.10
1.3
1.7
—
—
—
0
0
42
314
1.37
1.09
1.8
1.8
—
—
—
0
0
5
21
2.40
1.09
1.2
1.1
—
—
—
0
0
5
21
2.40
1.09
1.4
3.7
—
—
—
0
0
11
59
1.89
1.08
1.5
1.2
3.8
2.4
u/ml
—
5
21
12
67
1.81
1.05
1.5
1.5
7109.1
19038.5
e6/l
—
7
48
9
49
1.85
0.99
1.3
1.2
—
—
—
0
0
35
260
1.38
0.96
8.3
3.6
1.2
1.2
mmol/l
0.38
29
227
31
226
1.40
0.95
2.5
5.4
1.1
1.8
mmol/l
0.59
24
167
0
32
0.00
0.95
0.0
3.4
—
47.9
—
0
32
112
973
1.20
0.91
1.7
1.6
1.4
1.4
mmol/l
0.16
96
830
46
362
1.30
0.88
3.8
3.1
—
—
—
0
0
23
161
1.45
0.88
1.7
1.6
—
—
—
0
0
6
30
2.01
0.87
1.0
1.2
—
—
—
0
0
375
3614
1.22
0.85
4.5
4.1
1.5
1.5
mmol/l
0.08
350
3349
161
1452
1.17
0.84
3.9
3.4
—
—
—
0
0
8
46
1.75
0.83
1.1
1.8
—
—
—
0
0
14
89
1.59
0.82
1.3
1.7
—
—
—
0
0
10
164
0.60
0.81
1.3
1.8
—
—
—
0
0
8
48
1.68
0.79
1.4
1.1
—
—
—
0
0
22
157
1.42
0.78
4.5
2.7
0.7
0.7
%
0.34
22
151
6
34
1.77
0.76
1.2
1.1
—
—
—
0
0
6
34
1.77
0.76
2.8
3.6
—
—
—
0
0
14
92
1.54
0.73
1.3
1.6
—
—
—
0
0
16
109
1.49
0.72
3.6
6.5
8.7
8.8
kpa
0.08
16
100
361
3488
1.17
0.67
4.1
3.7
1.3
1.3
mmol/l
0.16
337
3223
0
20
0.00
0.60
0.0
2.0
—
—
—
0
0
0
20
0.00
0.60
0.0
2.0
—
—
—
0
0
0
20
0.00
0.60
0.0
2.0
—
—
—
0
0
0
20
0.00
0.60
0.0
2.0
—
—
—
0
0
0
21
0.00
0.60
0.0
2.0
—
1.4
—
0
15
14
97
1.46
0.59
3.4
2.5
—
—
—
0
0
6
35
1.72
0.58
1.2
1.2
—
—
—
0
0
5
89
0.56
0.56
1.2
1.2
—
1.0
—
0
8
101
909
1.14
0.54
5.2
4.6
1.8
2.3
ug/l
0.56
93
811
25
196
1.29
0.54
1.4
1.3
—
—
—
0
0
37
305
1.23
0.54
1.3
1.2
130.2
168.3
iu/ml
0.40
12
133
9
63
1.44
0.52
1.3
1.1
—
—
—
0
0
6
40
1.51
0.51
1.5
2.2
—
18.8
—
0
15
7
106
0.66
0.49
1.3
1.3
—
6.7
—
0
20
81
724
1.14
0.49
4.5
4.2
23.8
21.2
%
0.76
31
341
7
48
1.47
0.47
1.0
1.1
1.5
1.4
g/l
—
7
43
5
83
0.60
0.46
1.0
1.2
—
—
—
0
0
10
69
1.46
0.44
1.6
1.9
—
—
—
0
0
6
91
0.65
0.42
1.2
1.2
—
—
—
0
0
12
87
1.39
0.42
1.3
1.4
—
—
—
0
0
5
33
1.52
0.41
1.4
1.6
16.9
17.1
ug/l
—
5
33
0
15
0.00
0.41
0.0
1.2
—
8.2
—
0
15
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
11
149
0.73
0.40
1.5
1.4
—
—
—
0
0
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
5
34
1.48
0.40
1.4
2.0
12.8
13.4
%
—
5
34
5
34
1.48
0.40
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.2
—
—
—
0
0
5
35
1.43
0.39
1.0
1.2
—
—
—
0
0
32
272
1.19
0.37
1.6
2.5
61.8
70.4
ml/min/173m2
0.56
16
115
6
42
1.43
0.35
1.0
1.9
—
—
—
0
0
9
123
0.73
0.35
1.2
1.8
—
—
—
0
0
9
126
0.71
0.35
1.1
2.0
—
—
—
0
0
10
73
1.38
0.35
2.5
1.5
16.5
23.2
u/l
—
10
59
19
154
1.24
0.34
1.4
1.6
—
—
—
0
0
107
999
1.09
0.32
4.0
3.6
0.0
0.0
estimate
0.00
42
361
39
439
0.88
0.29
4.2
4.1
31.3
31.7
%
0.07
29
298
40
358
1.13
0.26
2.2
1.7
—
—
—
0
0
11
137
0.80
0.24
1.5
1.5
—
—
—
0
0
47
513
0.91
0.23
1.3
1.9
1.5
1.5
%
0.14
42
462
11
88
1.26
0.22
1.2
1.1
—
—
—
0
0
36
325
1.12
0.21
4.4
4.2
2.5
39.7
ug/l
0.88
29
269
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
5
43
1.16
0.21
1.0
1.3
—
—
—
0
0
11
89
1.24
0.21
4.6
3.8
—
2.6
—
0
11
38
417
0.90
0.20
5.6
5.9
—
—
—
0
0
6
48
1.25
0.20
1.3
1.7
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
2.4
—
—
—
0
0
0
14
0.00
0.20
0.0
3.5
—
—
—
0
0
0
14
0.00
0.20
0.0
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
49
1.23
0.20
1.3
1.6
—
—
—
0
0
26
231
1.13
0.20
1.0
1.0
—
—
—
0
0
14
118
1.19
0.19
1.0
1.1
—
—
—
0
0
20
175
1.15
0.19
1.5
1.5
—
—
—
0
0
14
119
1.18
0.18
1.0
1.1
—
—
—
0
0
34
311
1.10
0.17
1.4
1.5
—
—
—
0
0
59
627
0.93
0.17
2.2
2.1
—
—
—
0
0
9
82
1.10
0.15
1.8
1.8
—
—
—
0
0
19
212
0.89
0.14
3.8
2.6
45.2
45.8
u/ml
0.01
19
201
55
526
1.05
0.10
3.5
2.9
0.7
0.8
ug/l
0.04
37
339
66
685
0.96
0.09
2.3
2.3
—
—
—
0
0
13
116
1.12
0.09
1.2
1.5
—
—
—
0
0
88
854
1.04
0.09
3.5
3.4
1.0
1.0
kg/l
0.10
15
119
6
57
1.05
0.08
1.3
1.6
—
—
—
0
0
17
156
1.09
0.08
1.4
1.4
—
—
—
0
0
17
156
1.09
0.08
1.4
1.4
—
—
—
0
0
6
70
0.86
0.07
1.5
1.3
—
—
—
0
0
17
157
1.09
0.07
1.4
1.4
—
—
—
0
0
17
157
1.09
0.07
1.4
1.4
—
—
—
0
0
13
141
0.92
0.05
1.8
1.7
—
—
—
0
0
75
733
1.03
0.05
1.5
1.4
—
—
—
0
0
26
249
1.05
0.04
1.2
1.3
—
—
—
0
0
14
132
1.06
0.02
1.7
2.3
—
—
—
0
0
16
168
0.95
0.02
1.5
1.4
324.5
273.3
miu/ml
—
6
85
19
197
0.96
0.01
1.4
1.4
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
0.00
0.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.5
—
—
—
0
0
0
5
0.00
0.00
0.0
3.4
—
57.5
—
0
5
0
9
0.00
0.00
0.0
1.9
—
1.2
—
0
9
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
0.00
0.0
1.0
—
—
—
0
0
6
62
0.97
0.00
1.3
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
2.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H7_OPTICDISCOTH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.21 [0.93, 1.57] | 0.153 |
| Birth year | 0.995 [0.99, 1.0] | 0.202 |
During the follow-up period (1.1.1998 — 31.12.2019), 102 out of 1503 females with H7_OPTICDISCOTH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H7_OPTICDISCOTH | 1.083 [0.84, 1.4] | 0.538 |
| Birth year | 0.986 [0.98, 1.0] | 0.003 |
During the follow-up period (1.1.1998 — 31.12.2019), 94 out of 1051 males with H7_OPTICDISCOTH died.
Mortality risk
Mortality risk for people of age
years, who have H7_OPTICDISCOTH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.144% | 0.177% |
| 5 | 0.814% | 1.259% |
| 10 | 1.812% | 3.309% |
| 15 | 3.528% | 5.975% |
| 20 | 6.072% | 9.793% |
Relationships between endpoints
↥Index endpoint: H7_OPTICDISCOTH – Other disorders of optic disc
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
Loading data