No definition available.
Endpoint definition
↥Report an error or suggest an improvement for this endpoint codes
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
519972 |
1. Apply sex-specific ruleNone |
519972 |
2. Check conditionsNone |
519972 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
634 |
4. Check minimum number of eventsNone |
634 |
5. Include endpointsNone |
634 |
6. Filter based on genotype QC (FinnGen only) |
605 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H74
- Name in latin
- Morbus adhaesivus auris mediae
Similar endpoints
↥List of similar endpoints to
Adhesive middle ear disease
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7161 | 3318 | 3824 |
| Only index persons | 6710 | 3122 | 3588 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.10 | 0.11 |
| Only index persons | 0.13 | 0.11 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 23.56 | 31.19 | 16.81 |
| Only index persons | 23.60 | 31.18 | 17.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 605 | 340 | 265 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | 42.57 | 40.34 | 45.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 634
- Matched controls
- 6340
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
UDC00
NOMESCO Finland
Ear microscopy
22.2
308.9
274
210
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
307.7
593
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
768.3
263.6
242
5
H65.3
ICD-10 Finland
Chronic mucoid otitis media
986.3
219.9
203
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
16.6
214.5
209
182
Z01.1
ICD-10 Finland
Examination of ears and hearing
10.5
183.2
271
421
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
63.4
173.5
97
18
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
82.6
172.2
92
13
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
1874.4
156.0
145
*
H66.9
ICD-10 Finland
Otitis media, unspecified
13.1
151.7
164
164
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
149.0
137
*
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
78.4
141.2
76
11
DFF00
NOMESCO Finland
Pure tone audiometry
9.2
126.3
184
271
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
36.3
116.4
74
23
H65.2
ICD-10 Finland
Chronic serous otitis media
296.1
100.9
100
*
4122
FHL
Tympanostomy (tympanic tube)
285.6
97.6
97
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
57.7
93.5
53
10
H65.0
ICD-10 Finland
Acute serous otitis media
33.5
89.4
58
19
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
88.7
83
*
EMB30
NOMESCO Finland
Adenotomy
12.6
77.6
80
72
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
41.3
75.3
46
12
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
4.3
71.8
331
1294
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
35.4
67.5
43
13
DCD00
NOMESCO Finland
Myringoplasty
+∞
65.8
62
*
DC1AD
NOMESCO Finland
Temporalbone CT
186.9
65.4
67
*
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
57.2
54
*
4451
FHL
Guitar cutting
11.0
55.7
62
62
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.5
55.3
166
462
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
574.8
54.4
53
*
S02CA02
ATC
flumetasone and antiinfectives; otic
7.3
53.2
84
130
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
73.4
53.2
60
9
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
6.9
53.1
89
147
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
515.7
49.1
48
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
7.8
48.9
72
103
3851A
ICD-9 Finland
Other disorders of middle ear and mastoid, Adhesive middle ear disease
+∞
46.4
44
*
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic
12.6
45.9
46
39
DCD10
NOMESCO Finland
Tympanoplasty
+∞
43.2
41
*
H60.8
ICD-10 Finland
Other otitis externa
8.8
42.9
56
69
TDA90
NOMESCO Finland
Removal wax from ear
16.5
42.0
36
23
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
63.3
40.9
47
8
DAX08
NOMESCO Finland
Fitting of hearing aid
6.4
40.2
71
123
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.9
38.8
93
213
H66
ICD-10 Finland
Suppurative and unspecified otitis media
8.2
33.6
46
60
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
7.5
33.5
50
72
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.9
32.6
62
115
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
31.5
30
*
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
7.4
31.4
47
68
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
37.7
30.9
39
11
Z3229
NOMESCO Finland
Other healthcare associate professional
4.1
28.8
88
242
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
28.3
27
*
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
28.3
27
*
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
28.3
27
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
+∞
28.3
27
*
H60.3
ICD-10 Finland
Other infective otitis externa
7.9
27.9
39
52
DFF15
NOMESCO Finland
Speech audiometry
5.2
27.2
59
123
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
+∞
26.2
25
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
26.1
387
2473
H04
ICPC
Ear discharge
6.1
23.5
42
73
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
23.1
22
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
23.1
22
*
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
23.1
22
*
R01AD08
ATC
fluticasone; nasal
2.4
22.2
216
1127
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
+∞
22.0
21
*
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
22.0
21
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
20.9
20
*
J35.2
ICD-10 Finland
Hypertrophy of adenoids
5.3
20.5
42
83
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
+∞
19.9
19
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
19.9
19
*
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
19.9
19
*
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.7
19.5
65
189
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
3.0
19.5
96
356
H92.0
ICD-10 Finland
Otalgia
3.7
19.3
64
185
4742A
ICD-9 Finland
Chronic disease of tonsils and adenoids, Adenoid vegetations
7.0
18.8
29
43
1450
FHL
Otomicroscopy
31.1
18.5
24
8
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
20.1
18.3
27
14
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
3.4
18.1
70
224
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
185.0
17.6
18
*
R01BA52
ATC
pseudoephedrine, combinations; oral
2.2
16.7
180
963
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
16.7
16
*
R01AD09
ATC
mometasone; nasal
2.0
16.6
307
2012
ZXC10
NOMESCO Finland
Use of laser
6.5
16.4
27
43
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
15.7
15
*
DEB30
NOMESCO Finland
Radical mastoidectomy
163.9
15.5
16
*
ZXA10
NOMESCO Finland
Bilateral
2.3
15.4
131
633
J01DA08
ATC
[U] cefaclor
2.4
14.9
117
546
H61.2
ICD-10 Finland
Impacted cerumen
3.3
14.7
58
188
J01DA06
ATC
[U] cefuroxime
2.5
14.7
105
469
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
14.6
14
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
14.6
14
*
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
14.6
14
*
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
+∞
14.6
14
*
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic
5.6
14.6
28
52
J01DA01
ATC
[U] cefalexin
1.9
14.3
390
2863
H01
ICPC
Ear pain/earache
2.5
14.3
103
461
R5120
NOMESCO Finland
Preparation of an aid
4.9
13.9
31
66
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
13.6
13
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.4
12.7
46
141
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
71.3
12.6
14
*
DCA30
NOMESCO Finland
Exploration of middle ear
+∞
12.5
12
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
12.5
12
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
12.5
12
*
DCW00
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
12.5
12
*
H69.8
ICD-10 Finland
Other specified disorders of Eustachian tube
24.9
12.5
17
7
4141
FHL
Myringoplasty (also for reasons other than inflammation)
132.5
12.5
13
*
H02
ICPC
Hearing complaint
2.5
12.3
84
366
SPAT1263
SPAT
Sampling
1.8
12.1
287
1977
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.1
11.9
33
84
J01FA10
ATC
azithromycin; systemic
1.8
11.7
387
2937
H69.0
ICD-10 Finland
Patulous Eustachian tube
23.4
11.6
16
7
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
+∞
11.5
11
*
TDC10
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
11.5
11
*
R4135
NOMESCO Finland
Rehabilitation for hearing problems
8.6
11.4
24
29
H29
ICPC
Ear symptom/complaint other
2.5
11.3
79
347
SPAT1301
SPAT
No procedures
1.8
10.6
210
1358
H71
ICPC
Acute otitis media/myringitis
7.9
10.5
23
30
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
4.3
10.4
27
65
Z96.2
ICD-10 Finland
Presence of otological and audiological implants
+∞
10.4
10
*
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
10.4
10
*
H02AB06
ATC
prednisolone; systemic
1.7
10.4
275
1933
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.3
10.3
40
128
J01DB01
ATC
cefalexin; oral
2.0
10.1
522
4434
H80.9
ICD-10 Finland
Otosclerosis, unspecified
17.0
9.9
15
9
H13
ICPC
Plugged feeling ear
2.0
9.6
116
637
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
101.5
9.4
10
*
J01CA04
ATC
amoxicillin; systemic
2.0
9.4
535
4618
WX408
NOMESCO Finland
General anesthesy, balanced
1.8
9.4
158
967
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
+∞
9.4
9
*
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
9.4
9
*
R5140
NOMESCO Finland
Monitoring the use of the aid
2.4
9.3
69
311
J01FA09
ATC
clarithromycin; systemic
1.8
9.2
190
1236
J20
ICD-10 Finland
Acute bronchitis
2.3
9.1
69
315
H60.4
ICD-10 Finland
Cholesteatoma of external ear
37.3
9.0
11
*
TDM10
NOMESCO Finland
Puncture of maxillary antrum
3.4
9.0
32
97
H92.1
ICD-10 Finland
Otorrhoea
50.7
8.7
10
*
J35.1
ICD-10 Finland
Hypertrophy of tonsils
3.8
8.7
26
70
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.3
8.7
66
301
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
11.8
8.6
15
13
H72
ICD-10 Finland
Perforation of tympanic membrane
91.2
8.4
9
*
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
8.3
8
*
4151
FHL
Reoperation for chronic otitis media
+∞
8.3
8
*
UDC10
NOMESCO Finland
Tympanoscopy
33.8
8.1
10
*
J01MA02
ATC
ciprofloxacin; systemic
1.7
8.1
214
1482
SPAT1153
SPAT
Removal of sutures
1.7
8.0
176
1159
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
7.9
7.9
17
22
H61.8
ICD-10 Finland
Other specified disorders of external ear
11.0
7.8
14
13
SPAT1043
SPAT
Audiometry
2.2
7.7
64
303
ZYC03
NOMESCO Finland
Remote contact, text-based
25.3
7.6
10
*
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
7.5
165
1083
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
81.0
7.4
8
*
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.6
7.3
205
1433
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
7.3
7
*
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
2.4
7.2
49
213
DFF30
NOMESCO Finland
Loudness discomfort Level (LDL)
3.7
7.1
22
61
SPAT1312
SPAT
General health counselling
1.6
6.9
212
1511
DDA00
NOMESCO Finland
Stapedotomy
14.0
6.9
11
8
SPAT1033
SPAT
Irrigation or wax removal of outer auditory canal
1.8
6.8
101
590
H60
ICD-10 Finland
Otitis externa
2.5
6.8
41
168
SPAT1306
SPAT
Counselling and guidance related to nutrition and weight management
1.9
6.8
86
477
H90.8
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unspecified
16.9
6.8
10
6
R01AD12
ATC
fluticasone furoate; nasal
1.6
6.8
192
1343
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
1.9
6.7
88
495
J01AA02
ATC
doxycycline; systemic
1.6
6.6
416
3478
R01BA51
ATC
phenylpropanolamine, combinations; oral
1.8
6.6
96
558
R01AD05
ATC
budesonide; nasal
2.3
6.5
48
216
ZY020
NOMESCO Finland
Telephone, letter or other consultation without direct patient contact
2.4
6.4
45
198
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
70.5
6.4
7
*
H80.8
ICD-10 Finland
Other otosclerosis
70.5
6.4
7
*
Z01.8
ICD-10 Finland
Other specified special examinations
1.7
6.4
126
800
H70
ICPC
Otitis externa
4.1
6.4
17
42
A05
ICPC
Feeling ill
2.1
6.3
60
300
H74.4
ICD-10 Finland
Polyp of middle ear
+∞
6.3
6
*
3824A
ICD-9 Finland
Suppurative and unspecified otitis media, Unspecified suppurative otitis media
+∞
6.3
6
*
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
+∞
6.3
6
*
Q90.9
ICD-10 Finland
Down syndrome, unspecified
+∞
6.3
6
*
J01DA09
ATC
[U] cefadroxil
1.6
6.1
153
1036
EMB10
NOMESCO Finland
Tonsillectomy
2.3
6.0
45
204
SPAT1310
SPAT
Counselling related to known health issue
1.6
6.0
204
1481
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
106
512
2.29
12.31
7.4
6.8
—
—
—
0
0
48
177
2.85
9.74
1.9
1.7
—
—
—
0
0
49
193
2.67
8.79
1.9
1.9
—
—
—
0
0
92
524
1.88
6.73
4.4
4.0
31.15
31.45
%
0.08
55
348
62
337
1.93
5.22
2.8
2.3
5.11
7.63
ug/l
0.77
50
301
421
3647
1.46
4.73
6.3
7.3
76.17
78.15
u/l
0.44
393
3407
510
4611
1.54
4.47
4.4
4.0
5.92
5.83
mmol/l
0.72
453
4216
220
1707
1.44
4.44
3.8
3.5
28.65
36.41
ng/l
0.62
153
1092
545
5019
1.61
4.22
14.2
14.0
139.69
139.57
mmol/l
0.67
532
4868
240
1914
1.41
4.09
3.6
5.0
35.54
36.14
g/l
0.82
222
1792
545
5031
1.59
4.04
14.1
14.1
3.95
3.95
mmol/l
0.02
532
4869
30
140
2.20
3.83
1.2
1.3
—
—
—
0
0
155
1154
1.45
3.82
3.3
3.0
1012.93
1136.98
ng/l
0.32
125
960
410
3603
1.39
3.78
4.2
3.8
11.64
10.84
mm/h
0.61
373
3317
428
3804
1.39
3.58
3.8
3.8
14.83
14.68
pmol/l
0.53
379
3439
109
767
1.51
3.54
1.6
1.7
1251.28
1215.76
nmol/l
0.13
71
575
249
2040
1.36
3.47
15.0
12.8
1.38
1.22
inr
1.55
77
651
19
76
2.55
3.41
1.4
1.2
—
—
—
0
0
47
271
1.79
3.35
3.0
3.5
1.11
1.73
mmol/l
0.45
35
191
329
2824
1.34
3.34
3.8
4.7
6.91
6.61
mmol/l
0.97
300
2591
147
1110
1.42
3.32
2.6
2.6
9472.49
6862.46
umol/l
0.21
129
978
23
103
2.28
3.26
1.5
1.4
—
—
—
0
0
103
729
1.49
3.25
1.7
1.8
—
—
—
0
0
147
1117
1.41
3.20
3.7
3.8
1.02
1.02
kg/l
0.07
19
152
189
1506
1.36
3.08
2.8
2.6
50.95
59.56
u/l
1.74
173
1394
15
56
2.72
3.07
1.7
1.5
—
—
—
0
0
15
56
2.72
3.07
1.7
1.5
—
—
—
0
0
15
56
2.72
3.07
1.7
1.5
—
—
—
0
0
567
5349
1.57
3.06
9.3
9.5
28.52
26.67
u/l
0.90
544
5163
470
4290
1.37
3.00
5.7
5.2
39.75
39.17
mmol/mol
0.58
423
4004
15
57
2.67
2.98
1.7
1.5
—
—
—
0
0
15
57
2.67
2.98
1.7
1.5
—
—
—
0
0
216
1773
1.33
2.86
1.8
1.9
97.49
95.94
pmol/l
0.19
113
906
16
66
2.46
2.73
1.2
1.3
—
—
—
0
0
28
147
1.95
2.69
1.2
1.1
—
—
—
0
0
12
43
2.83
2.66
1.1
1.8
—
—
—
0
0
12
43
2.83
2.66
1.1
1.8
—
—
—
0
0
12
43
2.83
2.66
1.1
1.8
—
—
—
0
0
178
1446
1.32
2.49
3.1
3.2
8.12
7.94
mmol/l
0.18
148
1236
7
16
4.41
2.48
1.0
1.1
—
—
—
0
0
7
16
4.41
2.48
1.0
1.1
—
—
—
0
0
14
57
2.49
2.46
1.7
1.5
—
—
—
0
0
7
17
4.15
2.36
1.0
1.2
—
—
—
0
0
232
1965
1.28
2.36
3.7
3.6
—
—
—
0
0
537
5067
1.39
2.34
13.6
12.6
24.03
22.71
mg/l
0.37
450
3923
48
719
0.64
2.33
3.1
2.7
2.04
2.61
e6/l
0.27
36
379
157
1266
1.32
2.30
4.1
4.1
8.38
9.91
mg/mmol
0.20
97
825
12
47
2.58
2.28
1.6
1.8
—
—
—
0
0
7
18
3.92
2.25
1.0
1.2
—
—
—
0
0
5
9
5.59
2.21
1.0
1.4
—
—
—
0
0
515
4847
1.33
2.12
4.5
4.3
2.73
2.75
mmol/l
0.26
470
4496
8
25
3.23
2.10
1.0
1.9
—
—
—
0
0
8
25
3.23
2.10
1.0
1.9
—
—
—
0
0
10
37
2.73
2.07
1.8
1.3
—
—
—
0
0
19
96
2.01
2.07
1.6
1.5
8479.57
15798.26
e6/l
0.54
14
73
508
4778
1.32
2.06
4.2
4.0
4.54
4.61
mmol/l
0.97
466
4455
13
56
2.35
2.06
1.5
1.7
—
—
—
0
0
596
5759
1.58
2.03
19.5
18.3
40.51
41.24
%
0.40
547
5443
37
569
0.63
2.03
2.0
2.8
6.31
8.44
umol/l
0.50
29
483
10
38
2.66
2.01
1.8
1.3
—
—
—
0
0
276
2425
1.24
1.98
4.9
6.2
9.53
11.19
umol/l
4.45
260
2283
596
5766
1.56
1.93
19.7
18.2
4.56
4.54
e12/l
0.47
583
5613
596
5770
1.55
1.88
19.8
18.3
137.01
136.30
g/l
0.55
586
5688
150
1238
1.28
1.82
5.0
4.6
2.19
2.40
ug/l
0.24
128
1102
163
1362
1.26
1.79
3.7
3.8
0.00
0.00
estimate
0.50
43
505
122
983
1.30
1.79
4.3
4.2
19.86
21.14
%
0.39
54
441
486
4573
1.27
1.77
3.9
3.6
1.32
1.25
mmol/l
1.29
442
4226
503
4753
1.28
1.77
4.3
3.9
1.39
1.45
mmol/l
2.68
458
4417
6
18
3.35
1.75
1.3
1.4
—
—
—
0
0
6
18
3.35
1.75
1.0
1.1
—
—
—
0
0
6
18
3.35
1.75
1.3
1.4
—
—
—
0
0
48
333
1.48
1.74
2.5
2.3
5533.74
4421.02
u/l
0.14
14
145
249
2190
1.23
1.71
5.5
6.6
1.21
1.21
mmol/l
0.14
198
1858
594
5759
1.50
1.71
19.8
18.3
253.88
251.35
e9/l
0.39
582
5617
11
227
0.48
1.70
2.1
1.7
—
—
—
0
0
6
19
3.18
1.66
1.0
2.1
—
—
—
0
0
6
19
3.18
1.66
1.0
2.1
—
—
—
0
0
6
19
3.18
1.66
1.0
1.3
—
—
—
0
0
117
947
1.29
1.66
1.6
1.7
189796352.74
17215619.45
pmol/l
0.70
98
790
487
4596
1.26
1.65
4.7
4.5
1.84
2.13
mu/l
0.56
436
4224
27
166
1.65
1.64
1.5
1.3
—
—
—
0
0
119
1445
0.78
1.63
3.1
3.0
16.50
97.61
e6/l
1.14
101
1114
225
1969
1.22
1.61
2.1
2.3
73.55
74.59
nmol/l
0.21
193
1775
6
20
3.02
1.58
1.2
1.8
—
—
—
0
0
6
20
3.02
1.58
1.0
2.0
—
—
—
0
0
154
1299
1.25
1.55
1.7
1.6
—
—
—
0
0
32
210
1.55
1.51
2.6
3.6
0.66
0.65
%
0.09
32
210
126
1043
1.26
1.49
1.4
1.5
19.64
20.64
nmol/l
0.32
107
894
153
1296
1.24
1.48
2.2
2.0
220.31
306.78
u/l
0.37
140
1223
178
1535
1.22
1.45
2.3
3.3
2.36
2.35
mmol/l
0.65
155
1361
5
16
3.14
1.44
1.4
1.5
—
—
—
0
0
373
3452
1.20
1.42
3.0
3.1
44.13
41.85
u/l
0.27
349
3243
14
250
0.55
1.42
1.9
1.4
—
—
—
0
0
14
250
0.55
1.42
1.9
1.4
—
—
—
0
0
14
250
0.55
1.42
1.9
1.4
—
—
—
0
0
14
250
0.55
1.42
1.9
1.4
—
—
—
0
0
50
366
1.40
1.40
3.5
3.4
4.09
4.52
kpa
1.47
50
354
25
158
1.61
1.39
1.2
1.7
—
—
—
0
0
5
17
2.96
1.36
1.4
1.4
—
—
—
0
0
5
17
2.96
1.36
1.4
1.4
—
—
—
0
0
137
1158
1.23
1.35
2.0
2.1
—
—
—
0
0
0
41
0.00
1.31
0.0
1.5
—
—
—
0
0
11
55
2.02
1.28
2.2
2.7
18.60
23.88
mg/l
—
5
14
33
467
0.69
1.27
3.9
3.1
—
—
—
0
0
99
814
1.26
1.25
1.3
1.2
14.50
30.02
iu/ml
3.04
39
249
56
429
1.33
1.21
3.6
4.0
6.08
5.77
kpa
2.31
56
414
94
772
1.26
1.21
1.2
1.3
3.81
10.77
u/ml
1.61
36
316
18
109
1.67
1.20
1.8
2.5
582.80
58.94
ug/min
0.59
11
65
17
272
0.61
1.18
1.8
1.5
—
—
—
0
0
10
50
2.02
1.17
1.2
1.5
—
—
—
0
0
0
33
0.00
1.16
0.0
1.3
—
85.00
—
0
6
60
468
1.31
1.15
5.1
7.8
11.11
12.36
kpa
1.41
55
446
60
468
1.31
1.15
5.1
7.8
5.10
5.09
kpa
0.03
54
446
5
20
2.51
1.15
2.2
2.5
—
—
—
0
0
254
2307
1.17
1.13
2.3
2.6
—
—
—
0
0
8
41
1.96
1.09
1.0
1.1
—
—
—
0
0
58
462
1.28
0.98
5.2
8.0
1.21
1.12
mmol/l
0.07
44
370
71
581
1.25
0.97
3.6
5.8
1.04
1.05
mmol/l
0.12
60
535
10
173
0.57
0.96
2.2
3.9
16.40
580.40
u/ml
—
10
144
15
233
0.64
0.95
1.5
2.7
21.15
35.26
u/ml
1.02
15
224
14
85
1.66
0.95
1.3
1.5
—
—
—
0
0
8
144
0.55
0.94
1.1
1.2
—
—
—
0
0
432
4514
0.87
0.94
12.3
15.2
15.08
14.41
%
1.39
426
4448
14
86
1.64
0.91
1.7
1.5
—
—
—
0
0
17
110
1.56
0.91
1.6
1.3
—
—
—
0
0
268
2476
1.14
0.91
3.7
3.5
0.00
0.00
estimate
0.50
48
537
11
63
1.76
0.90
1.4
1.6
—
—
—
0
0
15
228
0.65
0.87
1.9
1.7
—
—
—
0
0
43
335
1.30
0.87
2.5
2.3
72.27
66.61
ml/min/173m2
0.49
22
136
309
2888
1.14
0.87
8.0
9.0
4.45
4.07
e9/l
1.85
284
2536
11
64
1.73
0.86
1.4
1.6
—
—
—
0
0
10
57
1.77
0.84
1.0
1.1
—
—
—
0
0
115
1310
0.85
0.83
3.0
2.9
0.16
0.45
e6/l
3.40
100
984
13
81
1.62
0.81
1.1
1.6
—
—
—
0
0
13
81
1.62
0.81
1.1
1.6
—
—
—
0
0
51
411
1.26
0.81
2.3
2.1
11.70
13.72
nmol/l
1.10
46
381
105
1201
0.85
0.80
1.7
1.6
1.39
1.38
mmol/l
0.06
89
1014
12
74
1.63
0.78
1.3
1.5
—
—
—
0
0
0
27
0.00
0.77
0.0
2.3
—
—
—
0
0
0
27
0.00
0.77
0.0
2.3
—
—
—
0
0
5
24
2.09
0.74
2.0
2.5
39100.00
37650.21
ug/l
—
5
24
268
2502
1.12
0.74
3.7
3.5
0.00
0.01
estimate
0.50
40
497
64
758
0.83
0.73
2.7
2.5
1.43
0.98
e6/l
0.47
52
412
24
177
1.37
0.71
1.7
1.7
31.38
39.16
nmol/l
1.86
24
170
5
26
1.93
0.70
2.0
2.8
1660.60
903.27
u/ml
—
5
26
7
41
1.72
0.70
2.9
2.7
—
—
—
0
0
5
27
1.86
0.68
2.2
3.0
—
—
—
0
0
480
4648
1.13
0.68
10.0
11.5
87.16
87.47
ml/min/173m2
0.10
405
3742
32
250
1.29
0.67
2.0
2.9
0.39
0.19
e6/l
0.42
32
241
120
1072
1.15
0.66
1.4
1.8
0.81
1.25
mg/l
1.80
81
800
38
305
1.26
0.65
3.6
4.0
109.81
75.78
ng/l
0.65
32
277
15
212
0.70
0.64
1.1
1.3
—
—
—
0
0
40
325
1.25
0.62
1.1
1.0
—
—
—
0
0
263
2473
1.11
0.62
4.9
4.7
0.00
0.00
estimate
0.50
44
516
8
49
1.64
0.62
1.0
1.1
—
—
—
0
0
10
63
1.60
0.62
1.2
2.6
104.30
106.10
mmol/l
—
10
63
14
96
1.47
0.62
5.8
3.7
5.05
3.96
e9/l
0.56
14
96
42
508
0.81
0.61
1.4
1.5
—
—
—
0
0
0
22
0.00
0.59
0.0
1.8
—
—
—
0
0
16
114
1.41
0.59
1.4
1.2
—
—
—
0
0
44
366
1.22
0.57
3.4
3.5
1.23
1.23
mmol/l
0.29
39
317
14
99
1.42
0.54
6.1
4.1
58.43
55.47
%
0.28
14
99
6
38
1.58
0.54
18.5
21.0
1386.50
1441.18
nmol/l
—
6
38
12
83
1.45
0.52
1.0
1.1
—
—
—
0
0
9
64
1.41
0.51
1.3
1.3
0.70
0.53
nmol/l
—
9
59
212
1991
1.10
0.50
5.3
5.9
1.21
1.21
mmol/l
0.14
183
1807
12
85
1.42
0.47
1.3
1.6
—
—
—
0
0
32
385
0.82
0.47
5.3
6.8
1.35
1.44
mmol/l
0.37
32
370
16
120
1.34
0.46
1.3
1.6
—
—
—
0
0
111
1015
1.11
0.45
2.3
2.2
—
—
—
0
0
35
294
1.20
0.44
1.5
1.4
—
—
—
0
0
88
796
1.12
0.43
2.3
2.9
2.43
2.44
mmol/l
0.22
75
689
5
31
1.62
0.43
1.0
1.2
2.48
1.79
mmol/l
—
5
31
18
140
1.29
0.42
1.4
2.1
199.67
642.39
ug/l
0.74
18
129
0
16
0.00
0.41
0.0
1.4
—
—
—
0
0
43
496
0.86
0.41
1.6
1.5
—
—
—
0
0
7
103
0.68
0.39
1.1
1.3
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
—
—
0
0
5
36
1.39
0.38
1.0
1.1
—
94.40
—
0
5
393
3820
1.08
0.38
3.2
3.4
—
—
—
0
0
9
69
1.31
0.37
1.0
1.1
—
—
—
0
0
8
115
0.69
0.37
1.1
1.2
—
—
—
0
0
5
37
1.35
0.37
1.8
2.1
—
—
—
0
0
130
1213
1.09
0.36
2.1
2.2
3.02
2.96
mg/l
0.12
112
1048
16
126
1.28
0.35
1.3
1.4
305.10
306.06
ug/g
—
10
69
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
15
118
1.28
0.33
1.3
1.6
—
—
—
0
0
6
87
0.69
0.33
1.0
1.3
—
—
—
0
0
6
87
0.69
0.33
1.0
1.3
—
—
—
0
0
28
240
1.17
0.30
1.3
1.9
—
—
—
0
0
27
314
0.85
0.30
1.6
1.4
—
—
—
0
0
52
469
1.12
0.29
2.0
1.8
372.72
381.51
nmol/l
0.11
46
428
7
57
1.23
0.29
1.0
1.1
—
—
—
0
0
15
121
1.25
0.28
1.0
1.4
479.47
403.05
mg/l
0.52
15
115
9
118
0.76
0.27
1.4
1.5
—
—
—
0
0
15
122
1.24
0.27
3.7
2.6
—
—
—
0
0
162
1696
0.94
0.26
3.4
3.0
—
—
—
0
0
9
72
1.25
0.25
1.1
1.1
1.43
1.46
g/l
—
9
65
79
848
0.92
0.25
2.9
3.4
64.09
568.49
ng/l
2.26
45
608
9
74
1.22
0.25
1.8
1.5
7.52
7.13
mmol/l
—
9
62
54
496
1.10
0.23
1.5
1.8
—
—
—
0
0
36
323
1.12
0.23
1.4
1.6
—
—
—
0
0
5
39
1.28
0.23
1.0
1.1
282.40
273.44
mg/l
—
5
34
5
40
1.25
0.22
1.0
1.7
—
—
—
0
0
65
604
1.08
0.22
2.3
2.3
18.86
23.80
%
2.56
53
528
5
41
1.22
0.22
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
26.61
—
0
11
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
8
102
0.78
0.21
2.5
5.1
—
462.57
—
0
14
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
7
59
1.19
0.18
1.0
1.2
—
—
—
0
0
235
2410
0.96
0.17
5.7
5.7
58.41
56.83
%
1.28
222
2277
12
142
0.84
0.17
4.0
2.1
—
—
—
0
0
27
243
1.12
0.17
1.2
1.3
168.04
262.07
miu/ml
1.06
15
124
115
1105
1.05
0.16
2.4
2.4
—
—
—
0
0
15
172
0.87
0.16
1.4
1.1
—
—
—
0
0
15
172
0.87
0.16
1.4
1.1
—
—
—
0
0
6
78
0.77
0.15
1.0
1.1
—
—
—
0
0
22
197
1.12
0.15
1.4
1.5
—
—
—
0
0
34
313
1.09
0.15
2.4
3.5
5.09
4.67
pmol/l
0.24
29
278
68
645
1.06
0.15
2.2
2.3
2.42
2.35
g/l
0.46
63
599
76
725
1.05
0.14
3.1
2.8
0.81
0.77
ug/l
0.18
48
452
239
2440
0.97
0.14
6.2
5.9
27.95
28.41
%
0.28
227
2306
9
106
0.85
0.13
1.8
1.6
—
—
—
0
0
137
1335
1.03
0.11
1.3
1.3
0.69
1.17
u/ml
1.77
43
356
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
115
0.87
0.10
4.6
3.2
0.41
0.34
u/ml
—
5
62
5
44
1.14
0.10
1.4
1.1
69.80
58.52
u/l
—
5
38
5
45
1.11
0.10
1.0
2.0
—
—
—
0
0
5
47
1.06
0.09
1.4
1.3
—
322.73
—
0
11
50
523
0.95
0.09
1.8
1.9
—
—
—
0
0
21
227
0.92
0.09
1.5
1.4
20.35
18.89
iu/l
0.08
21
192
7
64
1.09
0.08
1.7
1.3
—
—
—
0
0
34
358
0.95
0.08
1.4
1.3
—
—
—
0
0
8
77
1.04
0.07
1.1
2.1
—
1666.67
—
0
6
14
128
1.10
0.06
1.1
1.1
0.25
3.30
u/ml
—
6
74
233
2357
0.98
0.06
2.8
2.7
121.64
105.17
ug/l
0.48
216
2181
9
102
0.88
0.06
1.3
1.9
—
—
—
0
0
11
100
1.10
0.05
1.1
1.2
—
—
—
0
0
27
258
1.05
0.05
1.4
1.5
—
—
—
0
0
62
634
0.98
0.04
2.0
2.0
—
—
—
0
0
72
706
1.02
0.04
2.7
3.4
0.83
0.82
mmol/l
0.43
67
659
18
173
1.04
0.01
1.4
1.4
—
—
—
0
0
38
387
0.98
0.01
1.2
1.2
83.32
148.59
iu/ml
1.13
17
150
11
105
1.05
0.00
3.2
3.9
25.77
29.96
mg/l
—
6
67
12
125
0.96
0.00
1.0
1.4
—
—
—
0
0
23
225
1.02
0.00
1.4
1.7
11.05
3.25
mg/l
0.49
14
160
14
144
0.97
0.00
2.0
3.0
4.63
3.62
g/l
—
9
137
24
235
1.02
0.00
1.7
1.6
—
—
—
0
0
10
102
0.98
0.00
1.0
1.2
—
1.03
—
0
7
88
883
1.00
0.00
1.4
1.5
—
—
—
0
0
165
1647
1.00
0.00
3.1
3.4
30.82
31.68
u/l
0.14
158
1564
19
191
0.99
0.00
1.8
1.6
—
—
—
0
0
42
421
1.00
0.00
3.2
4.4
25.04
40.65
ug/l
0.29
31
352
49
491
1.00
0.00
1.4
1.7
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
11.00
—
0
5
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
5
52
0.96
-0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
-0.00
0.0
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.9
—
41.88
—
0
8
0
6
0.00
-0.00
0.0
1.2
—
—
—
0
0
6
69
0.87
-0.00
1.7
1.5
—
—
—
0
0
0
5
0.00
-0.00
0.0
2.2
—
—
—
0
0
9
97
0.93
-0.00
1.1
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.1
—
—
—
0
0
0
6
0.00
-0.00
0.0
4.8
—
9.65
—
0
6
0
5
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
7
72
0.97
-0.00
1.3
1.2
12.41
25.71
u/l
—
7
61
0
7
0.00
-0.00
0.0
6.7
—
15.03
—
0
7
5
56
0.89
-0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
4.4
—
—
—
0
0
0
6
0.00
-0.00
0.0
7.7
—
—
—
0
0
9
92
0.98
-0.00
1.2
1.4
—
—
—
0
0
5
56
0.89
-0.00
1.2
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MIDDLEADDH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 1.106 [0.97, 1.26] | 0.133 |
| Birth year | 0.997 [0.99, 1.01] | 0.534 |
During the follow-up period (1.1.1998 — 31.12.2019), 364 out of 2840 females with H8_MIDDLEADDH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 0.981 [0.85, 1.13] | 0.785 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 343 out of 3211 males with H8_MIDDLEADDH died.
Mortality risk
Mortality risk for people of age
years, who have H8_MIDDLEADDH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.176% |
| 5 | 0.686% | 1.216% |
| 10 | 1.732% | 2.881% |
| 15 | 3.336% | 5.368% |
| 20 | 5.743% | 8.851% |
Relationships between endpoints
↥Index endpoint: H8_MIDDLEADDH – Adhesive middle ear disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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