No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
2 out of 7 registries used, show all original rules. |
629 |
4. Check minimum number of eventsNone |
629 |
5. Include endpointsNone |
629 |
6. Filter based on genotype QC (FinnGen only) |
629 |
Control definitions (FinnGen only)
- Control exclude
- H8_MIDDLEMASTOID
Extra metadata
- Level in the ICD hierarchy
- 3
- First used in FinnGen datafreeze
- DF2
- Parent code in ICD-10
- H74
- Name in latin
- Morbus adhaesivus auris mediae
Similar endpoints
↥List of similar endpoints to
Adhesive middle ear disease
based on the number of shared cases.
Similar with more cases:
- Diseases of middle ear and mastoid
- Diseases of the ear and mastoid process
- Any event in hilmo or specialist outpatient
- Any prescribed medicine buy
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 7161 | 3318 | 3824 |
| Only index persons | 6710 | 3122 | 3588 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.10 | 0.10 | 0.11 |
| Only index persons | 0.13 | 0.11 | 0.14 |
| Median age at first event (years) | |||
| Whole population | 23.56 | 31.19 | 16.81 |
| Only index persons | 23.60 | 31.18 | 17.00 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 629 | 349 | 280 |
| Unadjusted period prevalence (%) | 0.12 | 0.12 | 0.12 |
| Median age at first event (years) | 41.89 | 39.86 | 44.44 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 566
- Matched controls
- 5661
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
H74.1
ICD-10 Finland
Adhesive middle ear disease
+∞
323.0
528
*
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
688.2
235.7
217
5
H65.3
ICD-10 Finland
Chronic mucoid otitis media
431.3
187.3
178
6
UDC00
NOMESCO Finland
Ear microscopy
24.8
157.0
233
155
H71
ICD-10 Finland
Cholesteatoma of middle ear
+∞
131.5
121
*
H72.0
ICD-10 Finland
Central perforation of tympanic membrane
771.6
128.8
122
*
H66.0
ICD-10 Finland
Acute suppurative otitis media
17.3
106.6
178
146
Z01.1
ICD-10 Finland
Examination of ears and hearing
10.5
103.5
231
350
4122
FHL
Tympanostomy (tympanic tube)
263.3
89.3
89
*
H65.2
ICD-10 Finland
Chronic serous otitis media
+∞
86.7
81
*
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
+∞
79.0
74
*
H66.9
ICD-10 Finland
Otitis media, unspecified
12.5
69.1
131
133
H90.6
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, bilateral
45.0
63.6
78
20
DFF00
NOMESCO Finland
Pure tone audiometry
9.4
63.1
141
193
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
59.6
62.7
73
14
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
4.4
56.6
294
1125
H65.9
ICD-10 Finland
Nonsuppurative otitis media, unspecified
186.4
49.7
51
*
DCD00
NOMESCO Finland
Myringoplasty
+∞
49.7
47
*
H68.1
ICD-10 Finland
Obstruction of Eustachian tube
46.9
48.6
59
14
H90.1
ICD-10 Finland
Conductive hearing loss, unilateral with unrestricted hearing on the contralateral side
33.6
48.3
63
21
DC1AD
NOMESCO Finland
Temporalbone CT
55.2
46.7
55
11
H66.3
ICD-10 Finland
Other chronic suppurative otitis media
+∞
46.5
44
*
DGW00
NOMESCO Finland
Dilatation of eustachian tube
+∞
46.5
44
*
3851A
ICD-9 Finland
Other disorders of middle ear and mastoid, Adhesive middle ear disease
+∞
43.3
41
*
H66.4
ICD-10 Finland
Suppurative otitis media, unspecified
97.6
41.4
45
5
H65.1
ICD-10 Finland
Other acute nonsuppurative otitis media
116.1
40.3
43
*
H72.2
ICD-10 Finland
Other marginal perforations of tympanic membrane
414.9
39.6
39
*
DCD10
NOMESCO Finland
Tympanoplasty
+∞
36.9
35
*
EMB30
NOMESCO Finland
Adenotomy
10.5
34.4
69
74
H90.3
ICD-10 Finland
Sensorineural hearing loss, bilateral
4.3
33.0
139
399
H65.0
ICD-10 Finland
Acute serous otitis media
23.7
32.3
46
21
S02CA02
ATC
flumetasone and antiinfectives; otic
7.1
30.6
78
124
H90.0
ICD-10 Finland
Conductive hearing loss, bilateral
32.1
29.8
39
13
H72.9
ICD-10 Finland
Perforation of tympanic membrane, unspecified
84.7
29.1
32
*
4451
FHL
Guitar cutting
11.0
28.9
56
56
H70.1
ICD-10 Finland
Chronic mastoiditis
+∞
28.4
27
*
Z46.1
ICD-10 Finland
Fitting and adjustment of hearing aid
6.7
27.4
73
123
H90.7
ICD-10 Finland
Mixed conductive and sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
29.5
27.0
36
13
38402
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) non definita
+∞
26.2
25
*
H60.8
ICD-10 Finland
Other otitis externa
10.4
24.3
48
50
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
+∞
23.1
22
*
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.4
22.7
335
2114
DEB25
NOMESCO Finland
Attico-antro-mastoidectomy and tympanoplasty
+∞
22.0
21
*
1450
FHL
Otomicroscopy
62.5
21.0
24
*
DEB20
NOMESCO Finland
Attico-antro-mastoidectomy and tympanotomy
+∞
21.0
20
*
Z97.4
ICD-10 Finland
Presence of external hearing-aid
6.9
20.9
53
83
S03CA01
ATC
dexamethasone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
11.9
20.8
38
34
4121
FHL
Tympanic puncture or parasentosis in general anesthesia or operating room
28.3
20.2
27
10
38100
ICD-8 Finland
Otitis media without mention of mastoiditis, Acute
+∞
19.9
19
*
3821A
ICD-9 Finland
Suppurative and unspecified otitis media, Chronic tubotympanic suppurative otitis media
+∞
19.9
19
*
H65.4
ICD-10 Finland
Other chronic nonsuppurative otitis media
206.9
19.7
20
*
DEA10
NOMESCO Finland
Attico-antrotomy
+∞
18.9
18
*
3853A
ICD-9 Finland
Other disorders of middle ear and mastoid, Cholesteatoma of middle ear and mastoid
+∞
18.9
18
*
H66.1
ICD-10 Finland
Chronic tubotympanic suppurative otitis media
+∞
18.9
18
*
H60.9
ICD-10 Finland
Otitis externa, unspecified
4.3
18.1
70
180
H74.2
ICD-10 Finland
Discontinuity and dislocation of ear ossicles
+∞
17.8
17
*
38110
ICD-8 Finland
Otitis media without mention of mastoiditis, Chronic
+∞
17.8
17
*
TDA90
NOMESCO Finland
Removal wax from ear
14.5
17.5
29
21
R01AD08
ATC
fluticasone; nasal
2.4
17.3
186
962
DFF15
NOMESCO Finland
Speech audiometry
6.5
17.2
45
74
H69.0
ICD-10 Finland
Patulous Eustachian tube
+∞
16.7
16
*
H60.3
ICD-10 Finland
Other infective otitis externa
9.9
16.6
33
35
DAX08
NOMESCO Finland
Fitting of hearing aid
6.4
16.2
43
72
DEB10
NOMESCO Finland
Attico-antro-mastoidectomy
+∞
15.7
15
*
TDW99
NOMESCO Finland
Other minor procedure in surgery of ear, nose and larynx
5.9
15.3
43
78
DBD20
NOMESCO Finland
Plastic repair of external auditory canal
46.3
15.1
18
*
3842A
ICD-9 Finland
Other disorders of tympanic membrane, Perforation of tympanic membrane
+∞
14.6
14
*
38401
ICD-8 Finland
Other inflammatory diseases of ear, Rhinosalpingitis (otosalpingitis) chronica adhaesiva
+∞
14.6
14
*
H66
ICD-10 Finland
Suppurative and unspecified otitis media
7.9
14.6
33
44
DAX00
NOMESCO Finland
Adjustment or review of hearing aid
5.6
14.4
42
80
H72.8
ICD-10 Finland
Other perforations of tympanic membrane
43.7
14.2
17
*
H04
ICPC
Ear discharge
7.5
13.7
32
45
38700
ICD-8 Finland
Other disease of ear and mastoid process, Cholesteatoma of ear
+∞
13.6
13
*
J35.2
ICD-10 Finland
Hypertrophy of adenoids
6.2
13.5
36
61
DEB30
NOMESCO Finland
Radical mastoidectomy
143.3
13.5
14
*
4742A
ICD-9 Finland
Chronic disease of tonsils and adenoids, Adenoid vegetations
7.6
12.6
29
40
R01AD09
ATC
mometasone; nasal
1.9
12.6
263
1754
38210
ICD-8 Finland
Chronic otitis media with mastoiditis
+∞
12.5
12
*
H73.1
ICD-10 Finland
Chronic myringitis
+∞
12.5
12
*
H72.1
ICD-10 Finland
Attic perforation of tympanic membrane
+∞
12.5
12
*
H95.0
ICD-10 Finland
Recurrent cholesteatoma of postmastoidectomy cavity
132.8
12.5
13
*
DCB10
NOMESCO Finland
Freeing of adhesions of middle ear
132.8
12.5
13
*
J01DA01
ATC
[U] cefalexin; systemic
1.9
12.3
350
2597
R01BA52
ATC
pseudoephedrine, combinations; oral
2.1
12.2
161
892
J01DA06
ATC
[U] cefuroxime; systemic
2.6
12.2
97
421
R5110
NOMESCO Finland
Evaluation of the need for aids, the testing, fitting and choice of the aid, instruction in use and delivery of it
2.9
12.0
78
300
50099
ICD-8 Finland
Hypertrophy of tonsils and adenoids
3.0
11.1
65
234
ZXA10
NOMESCO Finland
Bilateral
2.3
10.9
109
531
UDH02
NOMESCO Finland
Rhinopharyngoscopy
3.6
10.9
49
145
H01
ICPC
Ear pain/earache
2.6
10.6
82
350
4141
FHL
Myringoplasty (also for reasons other than inflammation)
112.0
10.5
11
*
DCW00
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
10.4
10
*
J01DA08
ATC
[U] cefaclor; oral
2.3
10.4
105
510
H60.5
ICD-10 Finland
Acute otitis externa, noninfective
16.4
10.4
16
10
H69.8
ICD-10 Finland
Other specified disorders of Eustachian tube
33.2
10.4
13
*
J01CA04
ATC
amoxicillin; systemic
2.1
10.2
475
4056
R5130
NOMESCO Finland
Repair work or maintenance done on the aid
5.1
9.7
30
62
UDC10
NOMESCO Finland
Tympanoscopy
+∞
9.4
9
*
Z96.2
ICD-10 Finland
Presence of otological and audiological implants
+∞
9.4
9
*
DCW99
NOMESCO Finland
Other operation on eardrum and middle ear
+∞
9.4
9
*
H95.1
ICD-10 Finland
Other disorders following mastoidectomy
+∞
9.4
9
*
DDD05
NOMESCO Finland
Plastic repair of ossicular chain
+∞
9.4
9
*
J01FA10
ATC
azithromycin; systemic
1.7
9.4
343
2651
H61.2
ICD-10 Finland
Impacted cerumen
3.6
9.2
41
121
H90.4
ICD-10 Finland
Sensorineural hearing loss, unilateral with unrestricted hearing on the contralateral side
4.4
8.9
31
73
H02
ICPC
Hearing complaint
2.6
8.7
65
270
H92.0
ICD-10 Finland
Otalgia
3.2
8.5
43
140
R5120
NOMESCO Finland
Preparation of an aid
6.4
8.4
21
34
DDD10
NOMESCO Finland
Interposition between malleus and stapes
+∞
8.4
8
*
4151
FHL
Reoperation for chronic otitis media
+∞
8.4
8
*
J01DB01
ATC
cefalexin; oral
1.8
8.2
451
3861
H80.0
ICD-10 Finland
Otosclerosis involving oval window, nonobliterative
11.9
8.1
14
12
H02AB06
ATC
prednisolone; systemic
1.7
7.8
235
1683
4150
FHL
Tympanoplasty (including for reasons other than inflammation)
45.6
7.7
9
*
H71
ICPC
Acute otitis media/myringitis
7.6
7.7
17
23
J01FA09
ATC
clarithromycin; systemic
1.8
7.7
173
1133
R5140
NOMESCO Finland
Monitoring the use of the aid
2.6
7.7
55
222
ZXC10
NOMESCO Finland
Use of laser
5.1
7.7
23
47
DCA30
NOMESCO Finland
Exploration of middle ear
81.1
7.4
8
*
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
2.4
7.4
60
263
4147
FHL
Radical surgery, cavity filling and middle ear and / or eardrum plastic
+∞
7.3
7
*
4144
FHL
Mastoidectomy or aticomastoidectomy
+∞
7.3
7
*
S03CA04
ATC
hydrocortisone and antiinfectives; ophthalmic, otic (ophth. and otological prep., corticosteroids and antiinfectives in comb.)
4.5
7.2
24
55
J35.1
ICD-10 Finland
Hypertrophy of tonsils
4.7
7.0
22
48
R4135
NOMESCO Finland
Rehabilitation for hearing problems
6.8
6.9
16
24
SPAT1263
SPAT
Sampling
1.6
6.8
240
1771
SPAT1223
SPAT
Implementation of physical therapy rehabilitation plan
1.7
6.7
143
919
H61.8
ICD-10 Finland
Other specified disorders of external ear
8.8
6.6
13
15
SPAT1301
SPAT
No procedures
1.7
6.5
179
1236
J01MA02
ATC
ciprofloxacin; systemic
1.6
6.5
188
1315
H13
ICPC
Plugged feeling ear
1.9
6.5
92
514
H72
ICD-10 Finland
Perforation of tympanic membrane
70.6
6.4
7
*
H60.4
ICD-10 Finland
Cholesteatoma of external ear
18.3
6.3
9
5
H73.8
ICD-10 Finland
Other specified disorders of tympanic membrane
+∞
6.3
6
*
H74.3
ICD-10 Finland
Other acquired abnormalities of ear ossicles
+∞
6.3
6
*
4145
FHL
Tympanomastoidectomy, includes possible tympanoplasty
+∞
6.3
6
*
Q35.1
ICD-10 Finland
Cleft hard palate
+∞
6.3
6
*
Q37.1
ICD-10 Finland
Cleft hard palate with unilateral cleft lip
+∞
6.3
6
*
TDC10
NOMESCO Finland
Removal of ventilating tube from tympanic membrane
+∞
6.3
6
*
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
+∞
6.3
6
*
UDQ12
NOMESCO Finland
Flexible laryngoscopy
3.0
6.3
33
113
H91.9
ICD-10 Finland
Hearing loss, unspecified
3.4
6.2
28
86
J01FF01
ATC
clindamycin; systemic
1.7
6.1
131
841
J20
ICD-10 Finland
Acute bronchitis
2.3
6.1
54
248
LabWAS
↥OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
105
507
2.29
12.21
7.5
6.8
—
—
—
0
0
47
174
2.84
9.47
1.9
1.7
—
—
—
0
0
48
189
2.67
8.62
1.9
1.9
—
—
—
0
0
91
520
1.88
6.59
4.5
4.0
31.4
31.5
%
0.04
54
339
62
335
1.94
5.31
2.8
2.3
5.1
7.7
ug/l
0.80
50
299
220
1687
1.47
4.80
3.8
3.5
28.9
36.6
ng/l
0.61
151
1076
418
3620
1.46
4.72
6.3
7.3
76.3
78.2
u/l
0.41
389
3379
506
4572
1.55
4.48
4.4
4.1
5.9
5.8
mmol/l
0.81
449
4183
240
1901
1.42
4.31
3.6
5.0
35.5
36.1
g/l
0.79
222
1778
541
4979
1.62
4.25
14.3
14.1
139.7
139.6
mmol/l
0.59
528
4829
541
4991
1.60
4.06
14.2
14.2
4.0
4.0
mmol/l
0.01
528
4830
155
1147
1.47
3.96
3.3
3.0
1012.9
1151.4
ng/l
0.36
125
955
30
139
2.22
3.89
1.2
1.3
—
—
—
0
0
109
759
1.53
3.73
1.6
1.7
1251.3
1216.0
nmol/l
0.13
71
568
407
3580
1.39
3.71
4.2
3.8
11.7
10.8
mm/h
0.66
370
3296
329
2803
1.36
3.63
3.8
4.7
6.9
6.6
mmol/l
0.93
300
2569
19
74
2.62
3.58
1.4
1.2
—
—
—
0
0
47
268
1.81
3.47
3.0
3.5
1.1
1.7
mmol/l
0.42
35
189
423
3766
1.38
3.44
3.8
3.8
14.8
14.7
pmol/l
0.50
375
3402
23
101
2.33
3.40
1.5
1.4
—
—
—
0
0
146
1100
1.43
3.34
3.7
3.8
1.0
1.0
kg/l
0.06
19
152
15
54
2.82
3.27
1.7
1.5
—
—
—
0
0
15
54
2.82
3.27
1.7
1.5
—
—
—
0
0
15
54
2.82
3.27
1.7
1.5
—
—
—
0
0
102
722
1.49
3.22
1.7
1.8
—
—
—
0
0
15
55
2.77
3.17
1.7
1.5
—
—
—
0
0
15
55
2.77
3.17
1.7
1.5
—
—
—
0
0
188
1495
1.37
3.11
2.8
2.6
51.1
56.1
u/l
1.85
172
1381
144
1097
1.41
3.08
2.6
2.6
10206.0
6588.1
umol/l
0.29
124
956
467
4257
1.38
3.06
5.8
5.2
39.8
39.1
mmol/mol
0.73
420
3972
216
1761
1.35
3.03
1.8
1.9
97.5
95.7
pmol/l
0.22
113
901
562
5306
1.56
2.96
9.4
9.5
28.5
26.7
u/l
0.90
539
5123
16
65
2.50
2.81
1.2
1.3
—
—
—
0
0
12
42
2.89
2.76
1.1
1.8
—
—
—
0
0
12
42
2.89
2.76
1.1
1.8
—
—
—
0
0
12
42
2.89
2.76
1.1
1.8
—
—
—
0
0
28
146
1.96
2.74
1.2
1.1
—
—
—
0
0
14
55
2.58
2.63
1.7
1.5
—
—
—
0
0
177
1437
1.32
2.49
3.1
3.2
8.1
7.9
mmol/l
0.18
147
1216
7
16
4.41
2.48
1.0
1.1
—
—
—
0
0
7
16
4.41
2.48
1.0
1.1
—
—
—
0
0
230
1945
1.29
2.38
3.7
3.6
—
—
—
0
0
7
17
4.15
2.36
1.0
1.2
—
—
—
0
0
156
1257
1.32
2.30
4.3
4.3
8.1
9.9
mg/mmol
0.25
96
819
12
47
2.58
2.28
1.6
1.8
—
—
—
0
0
7
18
3.92
2.25
1.0
1.2
—
—
—
0
0
532
5025
1.38
2.25
13.7
12.6
24.1
22.8
mg/l
0.38
445
3886
48
712
0.65
2.23
3.1
2.7
2.0
2.6
e6/l
0.28
36
373
5
9
5.59
2.21
1.0
1.4
—
—
—
0
0
10
36
2.81
2.21
1.8
1.3
—
—
—
0
0
8
24
3.36
2.18
1.0
1.9
—
—
—
0
0
8
24
3.36
2.18
1.0
1.9
—
—
—
0
0
8
24
3.36
2.18
1.0
1.9
—
—
—
0
0
8
24
3.36
2.18
1.0
1.9
—
—
—
0
0
19
95
2.03
2.12
1.6
1.5
8479.6
15631.6
e6/l
0.52
14
72
511
4809
1.33
2.11
4.5
4.3
2.7
2.8
mmol/l
0.23
465
4449
10
37
2.73
2.11
1.8
1.3
—
—
—
0
0
275
2404
1.26
2.10
4.9
6.2
9.5
11.2
umol/l
5.00
259
2264
504
4739
1.32
2.06
4.2
4.0
4.5
4.6
mmol/l
0.99
461
4410
13
56
2.35
2.06
1.5
1.7
—
—
—
0
0
37
564
0.63
1.96
2.0
2.9
6.3
8.5
umol/l
0.51
29
479
591
5721
1.55
1.86
19.9
18.4
136.9
136.3
g/l
0.47
581
5640
149
1228
1.28
1.84
5.0
4.7
2.2
2.4
ug/l
0.25
127
1092
48
329
1.50
1.83
2.5
2.3
5533.7
4402.4
u/l
0.14
14
142
117
936
1.31
1.81
1.6
1.7
189796352.7
17436327.7
pmol/l
0.69
98
780
121
974
1.30
1.79
4.3
4.2
19.9
21.1
%
0.37
53
436
161
1344
1.27
1.79
3.8
3.8
0.0
0.0
estimate
0.50
43
501
482
4533
1.27
1.78
3.9
3.6
1.3
1.2
mmol/l
1.42
438
4188
499
4714
1.28
1.77
4.3
3.9
1.4
1.4
mmol/l
3.23
453
4373
6
18
3.35
1.75
1.0
2.1
—
—
—
0
0
6
18
3.35
1.75
1.3
1.4
—
—
—
0
0
6
18
3.35
1.75
1.3
1.4
—
—
—
0
0
6
18
3.35
1.75
1.0
1.1
—
—
—
0
0
6
18
3.35
1.75
1.0
2.1
—
—
—
0
0
154
1284
1.26
1.72
1.7
1.6
—
—
—
0
0
11
228
0.47
1.72
2.1
1.7
—
—
—
0
0
406
4351
0.81
1.72
12.6
15.5
13.6
13.5
%
0.43
399
4277
6
19
3.18
1.66
1.0
1.3
—
—
—
0
0
6
19
3.18
1.66
1.0
2.1
—
—
—
0
0
224
1955
1.23
1.65
2.1
2.3
73.6
74.6
nmol/l
0.21
192
1760
247
2180
1.22
1.63
5.5
6.6
1.2
1.2
mmol/l
0.12
196
1839
153
1285
1.25
1.60
2.2
2.0
220.3
307.9
u/l
0.37
140
1213
126
1035
1.27
1.59
1.4
1.5
19.6
20.7
nmol/l
0.33
107
887
6
20
3.02
1.58
1.2
1.8
—
—
—
0
0
26
160
1.65
1.58
1.5
1.4
—
—
—
0
0
481
4545
1.25
1.57
4.7
4.5
1.8
2.1
mu/l
0.56
431
4173
25
153
1.66
1.55
1.2
1.8
—
—
—
0
0
178
1526
1.23
1.55
2.3
3.3
2.4
2.4
mmol/l
0.69
155
1345
32
209
1.56
1.54
2.6
3.9
0.7
0.7
%
0.03
32
203
137
1149
1.25
1.45
2.0
2.1
—
—
—
0
0
67
512
1.35
1.44
26.1
21.7
1.4
1.2
inr
0.57
23
75
50
364
1.41
1.44
3.5
3.7
4.1
4.5
kpa
1.44
50
352
5
16
3.14
1.44
1.4
1.5
—
—
—
0
0
11
53
2.09
1.39
2.2
2.7
18.6
25.3
mg/l
—
5
13
14
248
0.55
1.39
1.9
1.4
—
—
—
0
0
14
248
0.55
1.39
1.9
1.4
—
—
—
0
0
14
248
0.55
1.39
1.9
1.4
—
—
—
0
0
14
248
0.55
1.39
1.9
1.4
—
—
—
0
0
5
17
2.96
1.36
1.4
1.4
—
—
—
0
0
5
17
2.96
1.36
1.4
1.4
—
—
—
0
0
369
3423
1.19
1.34
3.1
3.1
44.4
41.8
u/l
0.32
345
3216
21
129
1.65
1.31
6.2
3.7
3.9
3.9
mmol/l
0.04
21
117
0
41
0.00
1.31
0.0
1.5
—
—
—
0
0
56
427
1.34
1.24
3.6
4.3
6.1
5.8
kpa
2.27
56
412
18
108
1.69
1.23
1.9
2.6
582.8
58.9
ug/min
0.59
11
65
33
463
0.70
1.22
3.9
3.1
—
—
—
0
0
98
808
1.25
1.22
1.3
1.2
14.5
30.3
iu/ml
3.08
39
246
60
465
1.32
1.20
5.1
7.9
5.1
5.1
kpa
0.04
54
443
60
465
1.32
1.20
5.1
7.9
11.1
12.4
kpa
1.41
55
443
253
2291
1.17
1.18
3.8
4.1
—
—
—
0
0
10
50
2.02
1.17
1.2
1.5
—
—
—
0
0
93
767
1.25
1.16
1.2
1.3
3.9
10.8
u/ml
1.56
35
314
5
20
2.51
1.15
2.2
2.5
—
—
—
0
0
17
270
0.62
1.15
1.8
1.5
—
—
—
0
0
71
574
1.27
1.06
3.6
5.9
1.0
1.0
mmol/l
0.11
60
528
58
459
1.29
1.02
5.2
8.0
1.2
1.2
mmol/l
0.04
44
362
14
223
0.62
0.98
1.9
1.7
—
—
—
0
0
308
2863
1.15
0.97
8.0
9.1
4.5
4.1
e9/l
1.88
283
2510
0
31
0.00
0.96
0.0
1.4
—
85.0
—
0
6
14
85
1.66
0.95
1.3
1.5
—
—
—
0
0
14
85
1.66
0.95
1.7
1.5
—
—
—
0
0
266
2451
1.15
0.95
3.6
3.4
0.0
0.0
estimate
0.00
42
503
10
172
0.57
0.94
2.2
3.9
16.4
584.4
u/ml
—
10
143
17
109
1.58
0.94
1.6
1.3
—
—
—
0
0
8
144
0.55
0.94
1.1
1.2
—
—
—
0
0
11
63
1.76
0.90
1.4
1.6
—
—
—
0
0
15
229
0.65
0.89
1.5
2.7
21.2
35.5
u/ml
1.03
15
220
8
42
1.92
0.89
1.0
1.1
—
—
—
0
0
114
1305
0.85
0.88
3.0
2.9
0.2
0.5
e6/l
3.44
96
976
11
64
1.73
0.86
1.4
1.6
—
—
—
0
0
10
57
1.77
0.84
1.0
1.1
—
—
—
0
0
51
411
1.26
0.81
2.3
2.1
11.7
13.8
nmol/l
1.17
46
377
39
305
1.30
0.78
3.6
3.9
109.8
75.6
ng/l
0.65
32
276
12
74
1.63
0.78
1.3
1.5
—
—
—
0
0
63
753
0.82
0.78
2.7
2.5
1.5
1.0
e6/l
0.51
51
408
42
333
1.28
0.77
2.5
2.4
72.0
66.4
ml/min/173m2
0.47
21
135
0
28
0.00
0.76
0.0
2.3
—
—
—
0
0
0
28
0.00
0.76
0.0
2.3
—
—
—
0
0
105
1195
0.85
0.76
1.7
1.6
1.4
1.4
mmol/l
0.09
89
1009
32
245
1.32
0.75
2.0
2.9
0.4
0.2
e6/l
0.41
32
236
266
2482
1.12
0.74
3.7
3.5
0.0
0.0
estimate
0.50
40
493
24
176
1.38
0.73
1.7
1.7
31.4
39.0
nmol/l
1.79
24
169
7
39
1.80
0.72
2.9
2.9
—
—
—
0
0
5
26
1.93
0.70
2.0
2.8
1660.6
903.3
u/ml
—
5
26
5
27
1.86
0.68
2.2
3.0
—
—
—
0
0
41
504
0.80
0.67
1.4
1.5
—
—
—
0
0
40
322
1.26
0.67
1.1
1.0
—
—
—
0
0
15
211
0.70
0.63
1.1
1.3
—
—
—
0
0
261
2453
1.11
0.62
4.9
4.7
0.0
0.0
estimate
0.50
44
511
8
49
1.64
0.62
1.0
1.1
—
—
—
0
0
10
63
1.60
0.62
1.2
2.6
104.3
106.1
mmol/l
—
10
63
14
96
1.47
0.62
5.8
3.7
5.1
4.0
e9/l
0.56
14
96
119
1071
1.14
0.60
1.4
1.8
0.8
1.2
mg/l
1.80
81
799
44
364
1.22
0.59
3.4
3.5
1.2
1.2
mmol/l
0.29
39
315
473
4592
1.12
0.59
10.1
11.5
87.2
87.4
ml/min/173m2
0.07
399
3694
0
22
0.00
0.59
0.0
1.8
—
—
—
0
0
16
114
1.41
0.59
1.4
1.2
—
—
—
0
0
14
99
1.42
0.54
6.1
4.1
58.4
55.5
%
0.28
14
99
6
38
1.58
0.54
18.5
21.0
1369.8
1441.2
nmol/l
—
6
38
9
62
1.46
0.53
1.3
1.3
0.7
0.5
nmol/l
—
9
57
12
83
1.45
0.52
1.0
1.1
—
—
—
0
0
111
1005
1.13
0.52
2.3
2.2
—
—
—
0
0
211
1982
1.10
0.50
5.3
6.0
1.2
1.2
mmol/l
0.17
182
1790
35
290
1.22
0.48
1.5
1.4
—
—
—
0
0
88
790
1.13
0.48
2.3
2.9
2.4
2.4
mmol/l
0.22
75
684
12
85
1.42
0.47
1.3
1.6
—
—
—
0
0
16
120
1.34
0.46
1.3
1.6
—
—
—
0
0
466
4772
0.91
0.46
11.3
13.3
40.6
40.3
%
0.31
288
3672
32
384
0.82
0.46
5.3
7.0
1.3
1.4
mmol/l
0.29
32
359
42
491
0.85
0.46
1.6
1.5
—
—
—
0
0
5
31
1.62
0.43
1.0
1.2
2.5
1.8
mmol/l
—
5
31
0
17
0.00
0.40
0.0
1.4
—
—
—
0
0
18
141
1.28
0.40
1.4
2.2
199.7
638.0
ug/l
0.74
18
130
5
34
1.47
0.40
1.0
1.1
—
—
—
0
0
7
103
0.68
0.39
1.1
1.3
—
—
—
0
0
5
35
1.43
0.39
1.0
1.1
—
94.4
—
0
5
129
1200
1.09
0.38
2.1
2.2
3.0
3.0
mg/l
0.15
111
1037
9
69
1.31
0.37
1.0
1.1
—
—
—
0
0
5
37
1.35
0.37
1.8
2.1
—
—
—
0
0
8
116
0.69
0.37
1.1
1.2
—
—
—
0
0
16
126
1.28
0.35
1.3
1.4
305.1
306.1
ug/g
—
10
69
6
43
1.40
0.35
1.2
1.1
—
—
—
0
0
28
237
1.19
0.34
1.3
1.9
—
—
—
0
0
389
3789
1.07
0.34
3.2
3.4
—
—
—
0
0
15
118
1.28
0.33
1.3
1.6
—
—
—
0
0
52
464
1.13
0.33
2.0
1.8
372.7
381.0
nmol/l
0.10
46
423
6
86
0.69
0.33
1.0
1.3
—
—
—
0
0
6
86
0.69
0.33
1.0
1.3
—
—
—
0
0
160
1684
0.93
0.30
3.5
3.1
—
—
—
0
0
7
57
1.23
0.29
1.0
1.1
—
—
—
0
0
15
121
1.25
0.28
3.7
2.6
—
—
—
0
0
27
312
0.86
0.28
1.6
1.5
—
—
—
0
0
9
116
0.77
0.27
1.4
1.5
—
—
—
0
0
15
122
1.24
0.27
1.0
1.5
479.5
402.1
mg/l
0.53
15
116
36
319
1.14
0.27
1.4
1.6
—
—
—
0
0
9
72
1.25
0.25
1.1
1.1
1.4
1.5
g/l
—
9
65
54
493
1.10
0.25
1.5
1.8
—
—
—
0
0
5
39
1.28
0.23
1.0
1.1
282.4
273.4
mg/l
—
5
34
5
40
1.25
0.22
1.0
1.7
—
—
—
0
0
79
842
0.93
0.22
2.9
3.4
65.3
571.5
ng/l
2.25
44
605
5
41
1.22
0.22
1.0
1.0
—
—
—
0
0
0
11
0.00
0.21
0.0
1.1
—
26.6
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.1
—
—
—
0
0
8
103
0.77
0.21
2.5
5.1
—
462.6
—
0
14
5
43
1.16
0.21
1.0
1.2
—
—
—
0
0
22
193
1.14
0.20
1.4
1.5
—
—
—
0
0
64
599
1.08
0.19
2.3
2.3
18.9
23.8
%
2.49
52
523
27
242
1.12
0.18
1.2
1.3
168.0
260.7
miu/ml
1.04
15
122
7
59
1.19
0.18
1.0
1.2
—
—
—
0
0
68
640
1.07
0.18
2.3
2.3
2.4
2.3
g/l
0.49
63
594
34
310
1.10
0.18
2.4
3.5
5.1
4.7
pmol/l
0.23
29
276
12
142
0.84
0.17
4.0
1.9
7.1
7.4
g/l
—
5
110
12
142
0.84
0.17
4.0
1.9
—
—
—
0
0
76
719
1.06
0.17
3.1
2.8
0.8
0.8
ug/l
0.18
48
447
114
1095
1.05
0.16
2.4
2.4
—
—
—
0
0
6
78
0.77
0.15
2.3
3.2
21.7
58.3
u/ml
—
6
71
6
78
0.77
0.15
1.0
1.1
—
—
—
0
0
15
171
0.87
0.15
1.4
1.1
—
—
—
0
0
15
171
0.87
0.15
1.4
1.1
—
—
—
0
0
20
223
0.89
0.14
1.5
1.4
19.3
18.9
iu/l
0.02
20
187
(3020427) Coagulation factor X inhibitor [Units/volume] in Platelet poor plasma by Coagulation assay
10
117
0.85
0.13
4.6
3.4
0.4
0.3
u/ml
—
5
62
9
106
0.85
0.13
1.8
1.6
—
—
—
0
0
136
1323
1.04
0.11
1.3
1.3
0.7
1.2
u/ml
1.71
42
352
5
48
1.04
0.09
1.4
1.3
—
322.7
—
0
11
50
522
0.95
0.09
1.8
1.9
—
—
—
0
0
7
64
1.09
0.08
1.7
1.3
—
—
—
0
0
6
70
0.86
0.07
1.7
1.5
—
—
—
0
0
8
77
1.04
0.07
1.1
2.1
—
1666.7
—
0
6
27
255
1.06
0.07
1.4
1.5
—
—
—
0
0
34
356
0.95
0.06
1.4
1.3
—
—
—
0
0
11
99
1.11
0.06
1.1
1.2
—
—
—
0
0
9
102
0.88
0.06
1.3
1.9
—
—
—
0
0
72
701
1.03
0.06
2.7
3.4
0.8
0.8
mmol/l
0.20
66
651
14
129
1.09
0.05
1.1
1.1
0.2
2.5
u/ml
—
5
55
23
219
1.05
0.04
1.4
1.7
3.5
3.3
mg/l
0.06
13
151
62
634
0.98
0.04
2.1
2.0
—
—
—
0
0
18
170
1.06
0.04
1.4
1.4
—
—
—
0
0
232
2334
0.99
0.02
2.8
2.7
122.1
105.6
ug/l
0.47
215
2159
38
387
0.98
0.01
1.2
1.2
83.3
147.9
iu/ml
1.12
17
151
11
104
1.06
0.01
3.2
3.9
25.8
30.2
mg/l
—
6
66
14
145
0.96
0.00
2.0
3.3
4.6
3.6
g/l
—
9
138
12
124
0.97
0.00
1.0
1.5
—
—
—
0
0
10
101
0.99
0.00
1.0
1.2
—
1.0
—
0
7
42
418
1.01
0.00
3.2
4.5
25.0
41.0
ug/l
0.29
31
349
49
488
1.00
0.00
1.4
1.7
—
—
—
0
0
163
1633
1.00
0.00
3.1
3.4
30.7
31.7
u/l
0.15
156
1551
87
872
1.00
0.00
1.4
1.5
—
—
—
0
0
23
231
1.00
0.00
1.6
1.6
—
—
—
0
0
0
8
0.00
0.00
0.0
1.1
—
—
—
0
0
5
52
0.96
0.00
1.0
1.0
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
6
64
0.94
0.00
1.0
1.4
—
10.6
—
0
9
0
5
0.00
0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
2.2
—
—
—
0
0
7
72
0.97
0.00
1.3
1.2
12.4
25.7
u/l
—
7
61
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
19
190
1.00
0.00
1.8
1.6
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
0
5
0.00
0.00
0.0
1.0
—
—
—
0
0
9
94
0.96
0.00
1.1
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
7.7
—
—
—
0
0
9
92
0.98
0.00
1.2
1.4
—
—
—
0
0
0
5
0.00
0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
11.0
—
0
5
0
7
0.00
0.00
0.0
6.7
—
15.0
—
0
7
0
9
0.00
0.00
0.0
1.1
—
—
—
0
0
Mortality – FinRegistry
↥Association
Association between endpoint H8_MIDDLEADDH and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 1.106 [0.97, 1.26] | 0.133 |
| Birth year | 0.997 [0.99, 1.01] | 0.534 |
During the follow-up period (1.1.1998 — 31.12.2019), 364 out of 2840 females with H8_MIDDLEADDH died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| H8_MIDDLEADDH | 0.981 [0.85, 1.13] | 0.785 |
| Birth year | 0.985 [0.98, 0.99] | 0.002 |
During the follow-up period (1.1.1998 — 31.12.2019), 343 out of 3211 males with H8_MIDDLEADDH died.
Mortality risk
Mortality risk for people of age
years, who have H8_MIDDLEADDH.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.124% | 0.176% |
| 5 | 0.686% | 1.216% |
| 10 | 1.732% | 2.881% |
| 15 | 3.336% | 5.368% |
| 20 | 5.743% | 8.851% |
Relationships between endpoints
↥Index endpoint: H8_MIDDLEADDH – Adhesive middle ear disease
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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