No definition available.
Endpoint definition
↥
Endpoint definition steps |
FinnGen |
|---|---|
Phenotype data |
520210 |
1. Apply sex-specific ruleNone |
520210 |
2. Check conditionsNone |
520210 |
3. Check pre-conditions, main-only, mode, registry filtersRegistry filters:
1 out of 7 registries used, show all original rules. |
472 |
4. Check minimum number of eventsNone |
472 |
5. Include endpointsNone |
472 |
6. Filter based on genotype QC (FinnGen only) |
472 |
Control definitions (FinnGen only)
Controls for this endpoint are individuals that are not cases.
Extra metadata
- Level in the ICD hierarchy
- C
- First used in FinnGen datafreeze
- DF5
Similar endpoints
↥List of similar endpoints to
Hypotension due to drugs
based on the number of shared cases.
Similar with more cases:
- Hypotension
- Other CVD (FINNGEN)
- Other CVD
- Cardiovascular diseases (excluding rheumatic etc)
- Cardiovascular diseases
Similar with less cases:
None
Case counts by codes
↥
Summary Statistics
↥-FinRegistry-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | |||
| Whole population | 4146 | 2120 | 2001 |
| Only index persons | 3614 | 1853 | 1761 |
| Unadjusted period prevalence (%) | |||
| Whole population | 0.06 | 0.06 | 0.06 |
| Only index persons | 0.07 | 0.07 | 0.07 |
| Median age at first event (years) | |||
| Whole population | 77.94 | 80.37 | 75.41 |
| Only index persons | 77.93 | 80.44 | 75.30 |
-FinnGen-
Key figures
| All | Female | Male | |
|---|---|---|---|
| Number of individuals | 472 | 186 | 286 |
| Unadjusted period prevalence (%) | 0.10 | 0.06 | 0.13 |
| Median age at first event (years) | 73.34 | 72.36 | 73.98 |
-FinRegistry-
Age distribution of first events
-FinnGen-
Age distribution of first events
-FinRegistry-
Year distribution of first events
-FinnGen-
Year distribution of first events
-FinRegistry-
Cumulative Incidence Function
-FinnGen-
Cumulative Incidence Function
CodeWAS (R11)
↥CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.
This is a new tool, please reach out using the contact form for feedback and improvement ideas.
First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.
Matched cohort
- Matched cases
- 427
- Matched controls
- 4268
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
I95.2
ICD-10 Finland
Hypotension due to drugs
+∞
323.0
427
6
C03CA01
ATC
furosemide; systemic
3.6
35.0
260
1281
I50.9
ICD-10 Finland
Heart failure, unspecified
3.8
30.4
161
585
C07AB07
ATC
bisoprolol; oral
3.3
29.2
301
1787
R55
ICD-10 Finland
Syncope and collapse
4.3
26.8
113
329
R07.4
ICD-10 Finland
Chest pain, unspecified
3.2
25.8
186
831
C01DA14
ATC
isosorbide mononitrate; oral
3.3
25.7
168
700
I95.9
ICD-10 Finland
Hypotension, unspecified
15.4
25.4
42
30
I25.1
ICD-10 Finland
Atherosclerotic heart disease
3.0
23.9
194
929
R42
ICD-10 Finland
Dizziness and giddiness
3.2
23.5
158
661
C03DA01
ATC
spironolactone; oral
4.0
23.1
105
323
R06.0
ICD-10 Finland
Dyspnoea
3.0
21.4
163
736
I10
ICD-10 Finland
Essential (primary) hypertension
2.9
21.2
324
2224
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
3.1
21.1
144
603
R53
ICD-10 Finland
Malaise and fatigue
3.0
20.8
146
623
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.6
20.2
245
1447
206
Kela drug reimbursment
Chronic coronary artery disease and dyslipidaemia associated with chronic coronary artery disease
2.8
19.5
164
777
C01DA08
ATC
isosorbide dinitrate; oral, oral aerosol, sublingual, transdermal
2.7
19.2
180
909
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
3.3
18.8
110
407
N05AH04
ATC
quetiapine; oral
3.3
18.1
102
367
I95.1
ICD-10 Finland
Orthostatic hypotension
6.2
18.0
50
90
I48
ICD-10 Finland
Atrial fibrillation and flutter
2.5
17.5
185
985
T36
ICD-10 Finland
Poisoning by systemic antibiotics
8.6
17.4
38
48
I25.0
ICD-10 Finland
Atherosclerotic cardiovascular disease, so described
4.2
16.8
68
185
F32.9
ICD-10 Finland
Depressive episode, unspecified
4.4
16.7
64
166
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
2.6
16.6
157
783
AN1
HP
Coronary angiography
3.0
16.2
107
426
205
Kela drug reimbursment
Chronic hypertension
2.4
15.8
203
1181
I50.0
ICD-10 Finland
Congestive heart failure
3.4
15.7
85
293
I20.09
ICD-10 Finland
Unstable angina
4.1
15.6
63
171
A49.9
ICD-10 Finland
Bacterial infection, unspecified
3.2
15.3
90
331
W01
ICD-10 Finland
Fall on same level from slipping, tripping and stumbling
2.4
15.3
176
961
B01AC04
ATC
clopidogrel; oral
2.7
15.0
120
537
AA1AD
NOMESCO Finland
CT of head and brain
2.5
14.7
152
785
I25.2
ICD-10 Finland
Old myocardial infarction
3.4
14.4
73
241
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.3
13.8
166
919
N05AX08
ATC
risperidone; systemic
3.6
13.5
65
205
C10AA01
ATC
simvastatin; oral
2.2
13.3
251
1692
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.5
13.1
125
612
E86
ICD-10 Finland
Volume depletion
6.3
12.5
33
56
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
12.4
157
879
112
Kela drug reimbursment
Severe psychotic and other severe mental disorders
4.4
12.2
45
112
C08CA01
ATC
amlodipine; oral
2.1
12.2
204
1291
X69
ICD-10 Finland
Intentional self-poisoning by and exposure to other and unspecified chemicals and noxious substances
9.1
12.2
25
29
I25.9
ICD-10 Finland
Chronic ischaemic heart disease, unspecified
2.6
12.1
102
464
C01DA02
ATC
glyceryl trinitrate; oral, oral aerosol, sublingual, transdermal
2.2
12.1
166
963
N03AG01
ATC
valproic acid; systemic, rectal
4.6
12.0
42
99
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.8
11.9
84
343
A02BC02
ATC
pantoprazole; systemic
2.1
11.6
294
2187
SPAT1250
SPAT
Comprehensive monitoring of chronic illness
2.2
11.6
154
876
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
2.3
11.4
119
603
ZXD05
NOMESCO Finland
Urgent procedure
2.2
11.3
155
890
I21.49
ICD-10 Finland
Acute subendocardial infarction unspecified coronary artery status
3.4
11.3
57
187
C09AA05
ATC
ramipril; oral
2.2
11.3
153
876
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
3.0
11.2
67
247
M04AA01
ATC
allopurinol; systemic
2.5
11.1
96
439
N02BE01
ATC
paracetamol; systemic, rectal
2.5
11.1
370
3077
XF400
NOMESCO Finland
ECG with 12 standard connections
2.4
11.0
105
510
SPAT1254
SPAT
Administration of medicine
2.5
10.9
93
424
SPAT1301
SPAT
No procedures
2.1
10.9
159
938
N06AX11
ATC
mirtazapine; oral
2.1
10.9
148
847
C07AB02
ATC
metoprolol; systemic
2.2
10.7
140
784
K59.09
ICD-10 Finland
Constipation, unspecified
3.6
10.7
49
149
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
2.8
10.7
72
287
B01AA03
ATC
warfarin; systemic
2.1
10.6
154
904
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
2.1
10.5
156
924
I20.99
ICD-10 Finland
Angina pectoris, unspecified
3.0
10.5
63
232
I50.1
ICD-10 Finland
Left ventricular failure
3.5
10.5
50
157
N05AX12
ATC
aripiprazole; systemic
8.5
10.4
22
27
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
3.5
10.4
49
152
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
2.4
10.3
98
471
N05AH03
ATC
olanzapine; systemic
4.8
10.3
34
76
H02AB06
ATC
prednisolone; systemic
1.9
9.9
216
1472
N30.0
ICD-10 Finland
Acute cystitis
2.5
9.8
82
370
SPAT1263
SPAT
Sampling
2.0
9.7
191
1250
F10.24
ICD-10 Finland
Alcohol depence active use
13.8
9.7
16
12
F29
ICD-10 Finland
Unspecified nonorganic psychosis
8.7
9.7
20
24
F20.9
ICD-10 Finland
Schizophrenia, unspecified
11.7
9.6
17
15
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.1
9.6
139
810
F10.00
ICD-10 Finland
Alcohol-related acute intoxication uncomplicated
11.0
9.4
17
16
213
Kela drug reimbursment
Fat metabolism disorder associated with chronic coronary artery disease
2.6
9.3
70
296
N06AB03
ATC
fluoxetine; oral
2.9
9.3
60
231
K59.0
ICD-10 Finland
Constipation
3.6
9.2
42
127
N05BA04
ATC
oxazepam; oral
2.1
9.2
120
666
C10AA05
ATC
atorvastatin; oral
1.9
9.2
196
1315
J01DB01
ATC
cefalexin; oral
2.1
9.2
336
2741
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
2.0
9.0
147
891
Z00.4
ICD-10 Finland
General psychiatric examination, not elsewhere classified
3.7
8.9
38
109
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
3.1
8.9
49
169
R07.3
ICD-10 Finland
Other chest pain
2.9
8.8
55
208
SPAT1262
SPAT
Handing over of treatment supplies
2.2
8.8
97
500
207
Kela drug reimbursment
Chronic arrhythmias
2.2
8.7
97
501
201
Kela drug reimbursment
Chronic cardiac insufficiency
3.1
8.7
49
173
D64.9
ICD-10 Finland
Anaemia, unspecified
2.5
8.7
72
322
F32.10
ICD-10 Finland
Moderate depressive episode without somatic syndrome
4.0
8.7
34
91
I20.90
ICD-10 Finland
Angina pectoris, unspecified
3.5
8.6
40
123
M54.5
ICD-10 Finland
Low back pain
2.0
8.6
134
796
M10.9
ICD-10 Finland
Gout, unspecified
3.0
8.6
50
181
S97
ICPC
Chronic ulcer skin
3.4
8.6
41
129
R51.80
ICD-10 Finland
Headache
2.6
8.6
64
271
F10.1
ICD-10 Finland
Mental and behavioural disorders due to use of alcohol, Harmful use
3.6
8.5
38
114
SPAT1230
SPAT
Aid fitting and borrowing and monitoring of use
2.2
8.4
93
478
N06AB10
ATC
escitalopram; oral
2.4
8.3
75
350
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
2.6
8.3
61
254
P29
ICPC
Psychological sympt/compl other
4.9
8.3
26
56
N05AH02
ATC
clozapine; systemic
14.8
8.2
13
9
A02BC05
ATC
esomeprazole; systemic
1.9
8.2
176
1169
T90
ICPC
Diabetes non-insulin dependent
2.0
8.2
113
639
M10
ICD-10 Finland
Gout
3.8
8.2
34
96
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
2.8
8.2
54
211
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
2.3
8.1
76
360
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
1.9
8.1
148
926
A46
ICD-10 Finland
Erysipelas
2.3
8.1
83
412
Z03.9
ICD-10 Finland
Observation for suspected disease or condition, unspecified
2.2
8.1
87
442
F33.9
ICD-10 Finland
Recurrent depressive disorder, unspecified
6.5
8.1
20
32
N05AA02
ATC
levomepromazine; systemic
4.0
8.0
31
82
M79.6
ICD-10 Finland
Pain in limb
1.9
8.0
146
917
R50.9
ICD-10 Finland
Fever, unspecified
2.4
8.0
73
344
N06AX16
ATC
venlafaxine; oral
2.9
7.9
49
184
SPAT1217
SPAT
Assessment of need for services (elderly/care support)
2.6
7.9
60
257
C01AA05
ATC
digoxin; systemic
2.3
7.9
79
389
R56.8
ICD-10 Finland
Other and unspecified convulsions
3.8
7.8
32
89
F32.2
ICD-10 Finland
Severe depressive episode without psychotic symptoms
4.3
7.8
28
69
A08
ICPC
Swelling
4.0
7.8
30
79
R03AC02
ATC
salbutamol; inhalant
1.8
7.8
207
1468
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.2
7.7
88
456
F33.30
ICD-10 Finland
Recurrent depression, severe episode without somatic syndrome
45.8
7.7
9
*
A28
ICPC
Limited function/disability NOS
2.0
7.7
104
581
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.1
7.6
91
483
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
2.2
7.6
81
408
X44
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified drugs, medicaments and biological substances
10.3
7.6
14
14
A12BA01
ATC
potassium chloride; oral
2.9
7.6
44
160
H3601, E113
ICD-10 Finland
NA
6.7
7.5
18
28
E16.2
ICD-10 Finland
Hypoglycaemia, unspecified
7.9
7.4
16
21
N05CF01
ATC
zopiclone; oral
1.8
7.4
158
1038
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.0
7.4
116
685
L28
ICPC
Limited function/disability (L)
2.1
7.4
93
502
H02AA02
ATC
fludrocortisone; oral
8.6
7.4
15
18
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
3.1
7.3
39
134
P99
ICPC
Psychological disorders other
9.6
7.3
14
15
ZXE04
NOMESCO Finland
Procedure duration 30 to 39 minutes
3.3
7.3
36
117
E66.8
ICD-10 Finland
Other obesity
4.6
7.3
24
55
I20.81
ICD-10 Finland
Other angina pectoris stenosed coronary artery
2.3
7.2
66
310
I95.8
ICD-10 Finland
Other hypotension
30.5
7.2
9
*
FN1AT
NOMESCO Finland
Endovascular dilatation of coronary arteries (PTCA)
2.9
7.2
42
154
F32.3
ICD-10 Finland
Severe depressive episode with psychotic symptoms
8.1
7.2
15
19
N06AB04
ATC
citalopram; systemic
2.0
7.2
97
541
N03AX12
ATC
gabapentin; oral
2.3
7.1
70
340
K78
ICPC
Atrial fibrillation/flutter
2.4
7.1
60
269
J44.9
ICD-10 Finland
Chronic obstructive pulmonary disease, unspecified
3.1
7.1
38
131
N17.9
ICD-10 Finland
Acute renal failure, unspecified
3.5
7.1
32
97
SPAT1222
SPAT
Counselling/guidance promoting independent living
2.1
7.1
84
444
C07AA07
ATC
sotalol; systemic
3.2
7.1
36
120
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
2.1
7.1
86
460
I11.0
ICD-10 Finland
Hypertensive heart disease with (congestive) heart failure
3.9
7.0
27
72
E87.5
ICD-10 Finland
Hyperkalaemia
6.0
7.0
18
31
FN1YT
NOMESCO Finland
Percutaneous insertion of coronary artery stent
2.8
6.9
44
169
WX892
NOMESCO Finland
Monitored bed care
2.7
6.9
47
187
Z02.7
ICD-10 Finland
Issue of medical certificate
3.0
6.9
39
138
SPAT1148
SPAT
Treatment of chronic ulcer or burn
2.1
6.9
77
397
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
2.5
6.9
54
235
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
1.7
6.9
184
1292
SPAT1229
SPAT
Assessment of need for aid
2.6
6.9
50
207
R03BB04
ATC
tiotropium bromide; inhalant
2.3
6.9
64
304
G47.3
ICD-10 Finland
Sleep apnoea
2.0
6.9
90
496
F31.9
ICD-10 Finland
Bipolar affective disorder, unspecified
6.3
6.8
17
28
J45.9
ICD-10 Finland
Asthma, unspecified
2.1
6.8
80
420
R41.8
ICD-10 Finland
Other and unspecified symptoms and signs involving cognitive functions and awareness
2.4
6.8
58
262
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
2.1
6.8
80
422
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
17.0
6.8
10
6
WZB00
NOMESCO Finland
Telephone receipt or other advice
1.9
6.8
106
624
A06AD11
ATC
lactulose; oral
1.9
6.7
101
586
AN4
HP
Balloon angioplasty and drug eluding stent
3.8
6.7
27
75
E11
ICD-10 Finland
Type 2 diabetes mellitus
2.1
6.7
79
417
A10AE04
ATC
insulin glargine; parenteral
2.5
6.7
53
233
N03AX16
ATC
pregabalin; oral
1.9
6.7
105
618
F41.9
ICD-10 Finland
Anxiety disorder, unspecified
3.6
6.6
28
81
C02AC05
ATC
moxonidine; oral
3.4
6.6
30
92
SPAT1249
SPAT
Treatment-related counselling outside office
1.8
6.6
158
1071
F31.8
ICD-10 Finland
Other bipolar affective disorders
8.9
6.6
13
15
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
2.3
6.6
59
273
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
3.0
6.6
37
131
N02AX02
ATC
tramadol; systemic, rectal
1.7
6.5
192
1380
N17
ICPC
Vertigo/dizziness
2.3
6.5
61
287
A11
ICPC
Chest pain NOS
2.7
6.5
42
163
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
2.9
6.5
38
139
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.0
6.5
84
460
R5140
NOMESCO Finland
Monitoring the use of the aid
2.6
6.5
48
201
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
2.9
6.5
37
133
R11
ICD-10 Finland
Nausea and vomiting
2.6
6.4
47
196
B01AB05
ATC
enoxaparin; parenteral
1.8
6.4
140
924
N05BA01
ATC
diazepam; systemic, rectal
2.2
6.4
65
322
N05AF03
ATC
chlorprothixene; systemic
6.1
6.4
16
27
K29
ICPC
Cardiovascular sympt/complt other
3.2
6.3
31
101
M25.5
ICD-10 Finland
Pain in joint
1.9
6.3
101
597
N04AA02
ATC
biperiden; systemic
9.5
6.3
12
13
ZXE11
NOMESCO Finland
Procedure duration 60 to 89 minutes
3.5
6.3
28
85
I95
ICD-10 Finland
Hypotension
18.3
6.3
9
5
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
18.3
6.3
9
5
F20.0
ICD-10 Finland
Paranoid schizophrenia
+∞
6.3
6
*
F60.31
ICD-10 Finland
Emotionally unstable personality disorder, borderline condition
27.1
6.2
8
*
N06AA09
ATC
amitriptyline; systemic
2.4
6.2
52
233
R03AK06
ATC
salmeterol and fluticasone; inhalant
2.1
6.2
68
347
N05BA06
ATC
lorazepam; systemic, sublingual
3.0
6.2
35
124
I42.0
ICD-10 Finland
Dilated cardiomyopathy
4.2
6.2
22
55
81
HP
Angiography of the heart and coronary arteries
2.4
6.2
54
247
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.0
6.2
81
444
TPH04
NOMESCO Finland
Cathetrisation of vein
1.9
6.1
98
579
TFP20
NOMESCO Finland
Cardiodefibrillation
2.5
6.1
47
203
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
2.9
6.1
35
126
F33.2
ICD-10 Finland
Recurrent depressive disorder, current episode severe without psychotic symptoms
4.7
6.0
19
42
I20.00
ICD-10 Finland
Unstable angina
3.1
6.0
31
105
I11.9
ICD-10 Finland
Hypertensive heart disease without (congestive) heart failure
3.0
6.0
34
120
TKC20
NOMESCO Finland
Catheterisation of bladder
2.4
6.0
49
218
CKC12
NOMESCO Finland
Photocoagulation of retina
3.6
6.0
25
72
Mortality – FinRegistry
↥Association
Association between endpoint HYPOTE_DRUGS and mortality.
Females
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HYPOTE_DRUGS | 2.009 [1.68, 2.4] | < 0.001 |
| Birth year | 0.997 [0.99, 1.01] | 0.442 |
During the follow-up period (1.1.1998 — 31.12.2019), 1003 out of 1827 females with HYPOTE_DRUGS died.
Males
| Parameter | HR [95% CI] | p-value |
|---|---|---|
| HYPOTE_DRUGS | 2.434 [1.91, 3.11] | < 0.001 |
| Birth year | 0.986 [0.98, 1.0] | 0.004 |
During the follow-up period (1.1.1998 — 31.12.2019), 948 out of 1685 males with HYPOTE_DRUGS died.
Mortality risk
Mortality risk for people of age
years, who have HYPOTE_DRUGS.| N-year risk | Females | Males |
|---|---|---|
| 1 | 0.193% | 0.515% |
| 5 | 1.172% | 2.872% |
| 10 | 2.94% | 6.92% |
| 15 | 5.423% | 12.823% |
| 20 | 9.768% | 21.299% |
Relationships between endpoints
↥Index endpoint: HYPOTE_DRUGS – Hypotension due to drugs
GWS hits: -
Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
Extremity
rg [CI]
Extremity
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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