Guttate psoriasis

L12_PSORI_GUTTATE

psoriasis: An autoimmune condition characterized by red, well-delineated plaques with silvery scales that are usually on the extensor surfaces and scalp. They can occasionally present with these manifestations: pustules; erythema and scaling in intertriginous areas, and erythroderma, that are often distributed on extensor surfaces and scalp.

Suggest a new description

Endpoint definition

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Endpoint definition steps	FinnGen
Phenotype data	520210
1. Apply sex-specific rule None	520210
2. Check conditions None	520210
3. Check pre-conditions, main-only, mode, registry filters Registry filters: Hospital discharge: ICD-10 — L40.4 Cause of death: ICD-10 — L40.4 2 out of 7 registries used, show all original rules.	518
4. Check minimum number of events None	518
5. Include endpoints None	518
6. Filter based on genotype QC (FinnGen only)	518

Control definitions (FinnGen only)

Control exclude: L12_PAPULOSQUAMOUS

Extra metadata

Level in the ICD hierarchy: 4
First used in FinnGen datafreeze: DF2
Parent code in ICD-10: L40
Name in latin: Psoriasis guttata

NAME	L12_PSORI_GUTTATE
CONTROL_EXCLUDE	L12_PAPULOSQUAMOUS
CONTROL_PRECONDITIONS
CONTROL_CONDITIONS
SEX
INCLUDE
PRE_CONDITIONS
CONDITIONS
OUTPAT_ICD
OUTPAT_OPER
HD_MAINONLY
HD_ICD_10_ATC
HD_ICD_10	L404
HD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
HD_ICD_10_EXCL
HD_ICD_9_EXCL
HD_ICD_8_EXCL
COD_MAINONLY
COD_ICD_10	L404
COD_ICD_9	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_8	$!$	The FinnGen clinical team has checked and no code can be used for this rule.
COD_ICD_10_EXCL
COD_ICD_9_EXCL
COD_ICD_8_EXCL
OPER_NOM
OPER_HL
OPER_HP1
OPER_HP2
KELA_REIMB
KELA_REIMB_ICD
KELA_ATC_NEEDOTHER
KELA_ATC
KELA_VNRO_NEEDOTHER
KELA_VNRO
CANC_TOPO
CANC_TOPO_EXCL
CANC_MORPH
CANC_MORPH_EXCL
CANC_BEHAV

Similar endpoints

↥

List of similar endpoints to Guttate psoriasis based on the number of shared cases.

Similar with more cases:

Similar with less cases:

None

Case counts by codes

↥

FinnGen case counts by registry codes:

Upset plot

Full data table

Summary Statistics

↥

-FinRegistry-

Key figures

	All	Female	Male
Number of individuals
Whole population	3699	2116	1568
Only index persons	3553	2064	1489
Unadjusted period prevalence (%)
Whole population	0.05	0.06	0.04
Only index persons	0.07	0.08	0.06
Median age at first event (years)
Whole population	41.77	41.62	41.86
Only index persons	41.40	41.48	41.29

-FinnGen-

Key figures

	All	Female	Male
Number of individuals	518	320	198
Unadjusted period prevalence (%)	0.10	0.11	0.09
Median age at first event (years)	46.58	44.06	50.65

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

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CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log₁₀(p-value) ≥ 6.

Matched cohort

Matched cases
466: Matched controls
4658

Code

Vocabulary

Description

Odds Ratio

-log₁₀(p)

N matched cases

N matched controls

D05AX52

ATC

calcipotriol, combinations; topical

195.0

323.0

321

L40.4

ICD-10 Finland

Guttate psoriasis

4503599627370496.0

323.0

460

L40.0

ICD-10 Finland

Psoriasis vulgaris

1243.5

323.0

331

D05AX02

ATC

calcipotriol; topical

137.0

230.1

234

D07XC01

ATC

betamethasone, combinations; topical

24.7

168.9

263

232

D07AC01

ATC

betamethasone; topical

13.2

133.6

364

989

D05BB02

ATC

acitretin; oral

108.8

125.3

133

E0000UV

ATC

12.0

119.6

380

1251

M07.3*L40.5

ICD-10 Finland

Other psoriatic arthropathies

+∞

111.0

102

D05AX03

ATC

calcitriol; topical

140.1

104.2

108

L04AX03

ATC

methotrexate; systemic (immunosuppressants)

15.9

99.4

175

170

E000001

ATC

8.8

94.2

258

574

WXQ27

NOMESCO Finland

UVB narrow spectrum light therapy

95.1

84.8

L40.5

ICD-10 Finland

Arthropathic psoriasis

960.6

84.3

L40.9

ICD-10 Finland

Psoriasis, unspecified

152.3

84.2

D07AC13

ATC

mometasone; topical

7.2

83.6

284

826

D07AD01

ATC

clobetasol; topical

8.9

81.0

203

371

L40

ICD-10 Finland

Psoriasis

96.6

80.3

D07AB08

ATC

desonide; topical

9.0

65.8

156

247

D07AB02

ATC

hydrocortisone butyrate; topical

5.8

65.5

262

850

M07.3

ICD-10 Finland

Other psoriatic arthropathies

606.4

55.8

E000002

ATC

7.5

54.3

144

262

319

Kela drug reimbursment

Adalimumab, brodalumab, certolizumab pegol, etanercept, guselkumab, infliximab, ixekizumab, risankizumab, sekukinumab and ustekinumab (skin psoriasis)

+∞

47.7

TQX10

NOMESCO Finland

Biopsy of skin and subcutaneous tissue

8.2

45.8

111

172

TQW80

NOMESCO Finland

Local dermatologic skincare

21.0

42.8

E000003

ATC

10.5

42.5

100

D02AE01

ATC

carbamide; topical

9.0

42.3

129

S91

ICPC

Psoriasis

69.2

38.8

D02AX

ATC

Other emollients and protectives

11.9

32.6

D05AA

ATC

Tars

94.5

32.2

E000007

ATC

7.8

31.6

113

L40.8

ICD-10 Finland

Other psoriasis

118.1

31.1

134

Kela drug reimbursment

General erythroderma

322.3

30.2

L04AB04

ATC

adalimumab; parenteral

23.5

28.8

L01BA01

ATC

methotrexate; systemic (folic acid analog.)

10.8

28.6

202

Kela drug reimbursment

Connective tissue diseases, rheumatoid arthritis and comparable disease

5.1

27.5

219

69619

ICD-8 Finland

Psoriasis and similar disorders, Psoriasis alia sive NUD (vulgaris)

+∞

24.2

6961A

ICD-9 Finland

Psoriasis and similar disorders, Other psoriasis[PSORIASIS VULGARIS]

+∞

21.0

L04AC05

ATC

ustekinumab; parenteral

219.4

20.7

NK4XE

NOMESCO Finland

Joint ultrasound examination not elsewhere classified

5.6

20.5

124

XQ848

NOMESCO Finland

Dermatological photography

12.6

19.1

E000006

ATC

4.9

19.0

149

L04AC10

ATC

secukinumab; parenteral

+∞

17.8

M07.0*L40.5

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

16.8

D07AA02

ATC

hydrocortisone; topical

3.1

15.1

345

L30.9

ICD-10 Finland

Dermatitis, unspecified

2.8

15.0

108

451

D01AC20

ATC

imidazoles/triazoles in combination with corticosteroids; topical

2.5

14.5

134

644

281

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab and tocilizumab

9.6

14.4

D07XB01

ATC

flumetasone, combinations; topical

29.3

13.0

H02AB06

ATC

prednisolone; systemic

2.1

12.6

229

1485

313

Kela drug reimbursment

Abatacept, adalimumab, anakinra, certolizumab pegol, etanercept, golimumab, infliximab, ixekizumab, sarilumab, secukinumab, tocilizumab and ustekinumab (rheumatoid diseases)

8.0

12.6

L40.3

ICD-10 Finland

Pustulosis palmaris et plantaris

13.9

12.0

TNX10

NOMESCO Finland

Arthrocentesis, unspecified region, unspecified region

3.9

11.9

140

A07EC01

ATC

sulfasalazine; oral, rectal

3.6

11.9

162

D09AB01

ATC

zinc bandage without supplements; topical

8.5

11.7

L04AD01

ATC

ciclosporin; systemic

8.7

11.4

L04AB01

ATC

etanercept; parenteral

13.1

11.2

J01FF01

ATC

clindamycin; systemic

2.2

11.2

143

790

6960A

ICD-9 Finland

Psoriasis and similar disorders, Psoriatic arthropathy

+∞

10.5

R2130

NOMESCO Finland

Counselling and guidance which enhance independent living

3.3

10.2

171

GD1AA

NOMESCO Finland

Thorax X-ray examination

1.9

10.2

190

1216

L04AA01

ATC

[U] ciclosporin; systemic

9.4

10.1

L04AC16

ATC

guselkumab; systemic

+∞

9.4

377

Kela drug reimbursment

Apremilast and dimethyl fumarate (psoriasis)

+∞

9.4

ND2AA

NOMESCO Finland

Hand and fingers X-ray examination

2.9

8.9

206

WQ066

NOMESCO Finland

91.7

8.4

L04AC18

ATC

risankizumab; parenteral

+∞

8.4

L04AC13

ATC

ixekizumab; parenteral

+∞

8.4

EB1HA

NOMESCO Finland

Panorama tomography of teeth and jaws or similar X-ray examination

1.8

7.8

199

1384

RJ411

NOMESCO Finland

15.3

7.7

F10.1

ICD-10 Finland

Mental and behavioural disorders due to use of alcohol, Harmful use

3.2

7.7

134

A46

ICD-10 Finland

Erysipelas

2.4

7.4

297

Z71.8

ICD-10 Finland

Other specified counselling

1.9

7.4

120

714

M54.5

ICD-10 Finland

Low back pain

1.8

7.3

156

1020

M07.2*L40.5

ICD-10 Finland

Psoriatic spondylitis

+∞

7.3

D05AX05

ATC

tazarotene; topical

+∞

7.3

M07.0

ICD-10 Finland

Distal interphalangeal psoriatic arthropathy

+∞

7.3

QXA25

NOMESCO Finland

Destruction of lesion of skin, site unspecified

7.5

7.2

SPAT1263

SPAT

Sampling

1.7

7.2

200

1415

RJ421

NOMESCO Finland

20.4

7.2

NH3AA

NOMESCO Finland

Foot and toes X-ray examination

2.6

6.9

195

JN3AE

NOMESCO Finland

Abdominal ultrasound examination

2.2

6.6

308

S18

ICPC

Laceration/cut

1.7

6.5

177

1236

L04AA32

ATC

apremilast; oral

+∞

6.3

J06.9

ICD-10 Finland

Acute upper respiratory infection, unspecified

1.6

6.1

214

1592

J01DB01

ATC

cefalexin; oral

1.8

6.1

380

3310

E11.9

ICD-10 Finland

Type 2 diabetes mellitus, without complications

2.0

6.1

482

Mortality – FinRegistry

↥

Association

Association between endpoint L12_PSORI_GUTTATE and mortality.

Females

Parameter	HR [95% CI]	p-value
L12_PSORI_GUTTATE	1.255 [1.02, 1.54]	0.032
Birth year	0.994 [0.99, 1.0]	0.2

During the follow-up period (1.1.1998 — 31.12.2019), 164 out of 1925 females with L12_PSORI_GUTTATE died.

Males

Parameter	HR [95% CI]	p-value
L12_PSORI_GUTTATE	1.695 [1.38, 2.08]	< 0.001
Birth year	0.986 [0.98, 1.0]	0.01

During the follow-up period (1.1.1998 — 31.12.2019), 209 out of 1420 males with L12_PSORI_GUTTATE died.

Mortality risk

Mortality risk for people of age

years, who have L12_PSORI_GUTTATE.

N-year risk	Females	Males
1	0.107%	0.352%
5	0.745%	1.989%
10	1.799%	4.954%
15	3.345%	9.073%
20	5.875%	14.936%

Relationships between endpoints

↥

Index endpoint: L12_PSORI_GUTTATE – Guttate psoriasis

GWS hits: -

Endpoint

Case Overlap

Survival Analysis

Genetic Correlations

Genetic Signals

N (Jaccard index)

HR [CI]

Extremity

rg [CI]

Extremity

Hits

Coloc Hits

FinRegistry

FinnGen

FinRegistry

FinnGen

Loading data

Guttate psoriasis

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

1. Apply sex-specific rule

2. Check conditions

3. Check pre-conditions, main-only, mode, registry filters

4. Check minimum number of events

5. Include endpoints

6. Filter based on genotype QC (FinnGen only)

Similar endpoints

Case counts by codes

Summary Statistics

-FinRegistry-

Key figures

-FinnGen-

Key figures

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

CodeWAS (R11)

Matched cohort

Mortality – FinRegistry

Association

Females

Males

Mortality risk

Relationships between endpoints