Renal tubulo-interstitial disorders in diseases classified elsewhere

N14_RENALTUBULOINOTH

pyelonephritis: Inflammation of the KIDNEY involving the renal parenchyma (the NEPHRONS); KIDNEY PELVIS; and KIDNEY CALICES. It is characterized by ABDOMINAL PAIN; FEVER; NAUSEA; VOMITING; and occasionally DIARRHEA.

Suggest a new description

Endpoint definition

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 N16*
  • Cause of death: ICD-10 N16*

2 out of 7 registries used, show all original rules.

341

4. Check minimum number of events

None

341

5. Include endpoints

None

341

6. Filter based on genotype QC (FinnGen only)

341

Control definitions (FinnGen only)

Control exclude
N14_RENALTUB

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF2

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

Key figures

All Female Male
Number of individuals
Whole population 1856 880 962
Only index persons 1584 749 835
Unadjusted period prevalence (%)
Whole population 0.03 0.03 0.03
Only index persons 0.03 0.03 0.03
Median age at first event (years)
Whole population 62.48 63.34 61.63
Only index persons 62.08 62.77 61.46

-FinnGen-

Key figures

All Female Male
Number of individuals 341 161 180
Unadjusted period prevalence (%) 0.07 0.05 0.08
Median age at first event (years) 58.65 55.86 61.14

-FinRegistry-

Age distribution of first events

-FinnGen-

Age distribution of first events

-FinRegistry-

Year distribution of first events

-FinnGen-

Year distribution of first events

-FinRegistry-

Cumulative Incidence Function

-FinnGen-

Cumulative Incidence Function

No data

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
304
Matched controls
3039
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
N18.9
ICD-10 Finland
Chronic kidney disease, unspecified
240.4
131.4
127
9
N16.2*D86.8
ICD-10 Finland
Renal tubulo-interstitial disorders in sarcoidosis
+∞
99.6
90
*
N18.8
ICD-10 Finland
Other chronic renal failure
488.3
78.7
75
*
123
Kela drug reimbursment
Chronic disorders of vitamin D metabolism
177.0
78.2
79
6
A11CC03
ATC
alfacalcidol; systemic
101.3
76.7
82
11
138
Kela drug reimbursment
Severe anaemia associated with chronic renal failure
851.8
71.1
67
*
D86.8
ICD-10 Finland
Sarcoidosis of other and combined sites
131.8
68.3
71
7
N17.9
ICD-10 Finland
Acute renal failure, unspecified
787.5
66.6
63
*
A12AA04
ATC
calcium carbonate; oral
248.0
60.5
60
*
N19
ICD-10 Finland
Unspecified kidney failure
91.3
59.9
65
9
Z94.0
ICD-10 Finland
Kidney transplant status
620.9
54.3
52
*
N10
ICD-10 Finland
Acute tubulo-interstitial nephritis
53.5
54.2
64
15
TK800
NOMESCO Finland
Hemodialysis
99.3
53.0
57
7
C03CA01
ATC
furosemide; systemic
7.1
52.9
175
487
N18.0
ICD-10 Finland
End-stage renal disease
+∞
51.5
48
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
6.8
51.2
227
916
KA3AT
NOMESCO Finland
Biopsy of kidney with ultrasound guidance
109.1
50.7
54
6
KAS10
NOMESCO Finland
Allogenic transplantation of kidney from cadaver donor
+∞
49.3
46
*
M04AA01
ATC
allopurinol; systemic
8.8
48.7
119
206
127
Kela drug reimbursment
Transplant complication
70.9
47.1
53
9
KH1AE
NOMESCO Finland
Urinary tract ultrasound examination
20.7
46.8
71
44
Z49.1
ICD-10 Finland
Extracorporeal dialysis
522.2
46.6
45
*
B03XA02
ATC
darbepoetin alfa; parenteral
99.5
46.5
50
6
L04AA06
ATC
mycophenolic acid; systemic
40.7
43.4
54
16
I15.1
ICD-10 Finland
Hypertension secondary to other renal disorders
249.4
43.1
43
*
N16.3*E83.50
ICD-10 Finland
Nefrocalcinosis NEC
+∞
41.6
39
*
N16.2
ICD-10 Finland
Renal tubulo-interstitial disorders in blood diseases and disorders involving the immune mechanism
+∞
41.6
39
*
137
Kela drug reimbursment
Uraemia requiring dialysis
+∞
40.5
38
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
11.9
39.2
76
83
L04AX01
ATC
azathioprine; systemic
17.4
38.5
62
44
Z49.0
ICD-10 Finland
Preparatory care for dialysis
+∞
38.3
36
*
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
7.0
36.0
101
202
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
11.3
35.0
69
77
PBL10
NOMESCO Finland
Construction of arteriovenous fistula from radial artery
372.8
33.6
33
*
KA1AE
NOMESCO Finland
Kidney ultrasound examination
26.8
33.4
46
20
E83.50
ICD-10 Finland
Hypercalcemia
37.2
33.2
42
13
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
4.6
33.1
163
613
B05DA
ATC
Isotonic solutions
+∞
32.9
31
*
KA2AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
31.8
30
*
190
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
31.8
30
*
N16.3*M10.9
ICD-10 Finland
Gout nephropathy
+∞
30.7
29
*
J01EE01
ATC
sulfamethoxazole and trimethoprim; systemic
10.5
30.0
61
71
Z49.2
ICD-10 Finland
Other dialysis
+∞
29.7
28
*
L04AD02
ATC
tacrolimus; systemic (calcineurin inhibitors)
73.7
29.6
33
5
C08CA01
ATC
amlodipine; oral
4.1
28.9
169
716
A49.9
ICD-10 Finland
Bacterial infection, unspecified
7.4
28.9
74
126
N16.1*C90.0
ICD-10 Finland
Renal tubulo-interstitial disorders in multiple myeloma
+∞
28.6
27
*
KA2AT
NOMESCO Finland
Biopsy of transplanted kidney with ultrasound guidance
+∞
28.6
27
*
H02AB04
ATC
methylprednisolone; systemic
5.2
28.1
102
270
L04AD01
ATC
ciclosporin; systemic
35.7
27.5
35
11
B05DB
ATC
Hypertonic solutions
+∞
27.5
26
*
132
Kela drug reimbursment
Sarcoidosis
28.9
26.9
36
14
196
Kela drug reimbursment
Paricalcitol and cinacalcet
+∞
26.4
25
*
M10.9
ICD-10 Finland
Gout, unspecified
8.4
26.4
61
88
205
Kela drug reimbursment
Chronic hypertension
4.0
26.1
144
563
D86.9
ICD-10 Finland
Sarcoidosis, unspecified
49.1
26.1
31
7
L04AA01
ATC
[U] ciclosporin; systemic
42.9
25.4
31
8
D86.0
ICD-10 Finland
Sarcoidosis of lung
23.8
24.0
34
16
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
4.7
23.9
93
260
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
4.9
23.3
85
221
V03AE01
ATC
polystyrene sulfonate; oral
70.8
23.2
26
*
N25.8
ICD-10 Finland
Other disorders resulting from impaired renal tubular function
+∞
22.1
21
*
V03AE02
ATC
sevelamer; oral
+∞
22.1
21
*
TPH90
NOMESCO Finland
Removal of fixed intravenous catheter
36.8
21.5
27
8
TPX10
NOMESCO Finland
Implantation of vascular injection port
16.5
21.3
34
23
A10AC01
ATC
insulin (human); parenteral (insulins and analog. for injection, intermediate-acting)
6.6
20.5
55
98
D86.2
ICD-10 Finland
Sarcoidosis of lung with sarcoidosis of lymph nodes
25.5
20.4
28
12
B03XA01
ATC
erythropoietin; parenteral
61.9
20.2
23
*
N16.3
ICD-10 Finland
Renal tubulo-interstitial disorders in metabolic diseases
+∞
20.0
19
*
A09
ICD-10 Finland
Other gastroenteritis and colitis of infectious and unspecified origin
4.3
20.0
85
254
M10.0
ICD-10 Finland
Idiopathic gout
12.2
19.8
36
33
H05BX01
ATC
cinacalcet; oral
213.3
19.8
20
*
H02AB06
ATC
prednisolone; systemic
3.1
19.5
185
1020
M05BA04
ATC
alendronic acid; oral
5.8
19.4
58
118
ZX120
NOMESCO Finland
Intravenous
5.1
19.3
66
157
TPH20
NOMESCO Finland
Insertion of central venous catheter through subclavian or brachiocephalic vein
14.8
19.2
32
24
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
8.0
18.6
43
61
C90.0
ICD-10 Finland
Multiple myeloma
27.1
18.5
25
10
N16.5*T86.9
ICD-10 Finland
Renal tubulo-interstitial disorder in transplant rejection
+∞
17.9
17
*
N16.4*M35.0
ICD-10 Finland
Sjögren's syndrome with renal tubulo-interstitial disorders
+∞
17.9
17
*
JAK10
NOMESCO Finland
Laparotomy and insertion of peritoneal dialysis catheter
+∞
17.9
17
*
320
Kela drug reimbursment
Lanthanum carbonate, sevelamer and sucroferric oxyhydroxide
+∞
17.9
17
*
M35.0
ICD-10 Finland
Sicca syndrome [Sjögren]
17.3
17.4
27
17
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
3.1
17.0
123
548
JN4AD
NOMESCO Finland
Body CT examination
5.4
16.9
53
114
TPH04
NOMESCO Finland
Cathetrisation of vein
3.4
16.7
98
377
JN3AD
NOMESCO Finland
Abdominal CT examination
6.4
16.7
45
80
NA3AA
NOMESCO Finland
Lumbar spine X-ray examination without contrast
4.8
16.3
57
138
PG1DE
NOMESCO Finland
Other extensive ultrasound examination of artery
8.0
16.1
37
52
JN1AE
NOMESCO Finland
Ultrasound examination of upper part of abdomen
4.9
16.1
56
135
N11.9
ICD-10 Finland
Chronic tubulo-interstitial nephritis, unspecified
+∞
15.8
15
*
TJA35
NOMESCO Finland
Removal of peritoneal dialysis catheter
+∞
15.8
15
*
A10AB05
ATC
insulin aspart; parenteral (insulins and analog. for injection, fast-acting)
5.8
15.7
46
91
XW000
NOMESCO Finland
Bone marrow biopsy
8.6
15.6
34
44
R4110
NOMESCO Finland
Physiotherapy
3.0
15.5
113
499
C08CA02
ATC
felodipine; oral
4.8
15.3
53
127
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
10.6
15.1
29
30
ZX108
NOMESCO Finland
Inhalation
33.6
15.0
19
6
L04AX04
ATC
lenalidomide; oral
59.8
14.9
17
*
153
Kela drug reimbursment
Lenalidomid
59.8
14.9
17
*
3AC01
NOMESCO Finland
NA
26.6
14.9
20
8
N08.39*E10.2
ICD-10 Finland
Insulin-dependent diabetes mellitus - Diabetic nephropathy
84.3
14.7
16
*
V03AE03
ATC
lanthanum carbonate; oral
+∞
14.7
14
*
B03XA03
ATC
methoxy polyethylene glycol-epoetin beta; parenteral
+∞
14.7
14
*
U14
ICPC
Kidney symptom/complaint
20.4
14.4
21
11
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.7
14.4
51
125
C07AB07
ATC
bisoprolol; oral
2.6
14.2
174
1037
117
Kela drug reimbursment
Leukaemia and other malignant diseases of the blood and bone marrow, and malignant diseases of the lymphatic tissue
7.1
13.9
34
53
N08.39*E11.2
ICD-10 Finland
Non-insulin-dependent diabetes mellitus - Diabetic nephropathy
35.9
13.6
17
5
N16.4*M32.1
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic lupus erythematosus
+∞
13.6
13
*
TK820
NOMESCO Finland
Peritoneal dialysis
+∞
13.6
13
*
B01AB10
ATC
tinzaparin; parenteral
5.5
13.6
41
84
A12AA12
ATC
[U] calcium acetate anhydrous; systemic
146.3
13.6
14
*
I12.0
ICD-10 Finland
Hypertensive renal disease with renal failure
146.3
13.6
14
*
321
Kela drug reimbursment
Paricalcitol and cinacalcet
146.3
13.6
14
*
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
4.2
13.4
54
150
I50.9
ICD-10 Finland
Heart failure, unspecified
3.8
13.4
61
189
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.9
13.2
94
401
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
6.9
13.2
33
53
A12BA01
ATC
potassium chloride; oral
6.6
12.8
33
55
A10AE04
ATC
insulin glargine; parenteral
4.4
12.7
48
125
K65.0
ICD-10 Finland
Acute peritonitis
21.2
12.6
18
9
E87.5
ICD-10 Finland
Hyperkalaemia
25.6
12.6
17
7
E11.8
ICD-10 Finland
Type 2 diabetes mellitus, with unspecified complications
4.5
12.6
46
116
N03.9
ICD-10 Finland
Chronic nephritic syndrome, unspecified
135.4
12.5
13
*
A41.0
ICD-10 Finland
Sepsis due to Staphylococcus aureus
12.4
12.5
22
19
C09AA02
ATC
enalapril; systemic
2.9
12.5
88
371
S97
ICPC
Chronic ulcer skin
6.6
12.5
32
53
J01FF01
ATC
clindamycin; systemic
2.7
12.4
107
515
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
3.0
12.3
80
322
J01MA12
ATC
levofloxacin; systemic
3.0
12.3
82
335
I10
ICD-10 Finland
Essential (primary) hypertension
2.4
12.3
197
1310
E11.7
ICD-10 Finland
Type 2 diabetes mellitus, with multiple complications
6.4
12.2
32
55
R50.9
ICD-10 Finland
Fever, unspecified
3.4
12.1
63
216
NA2AA
NOMESCO Finland
Thoracal spine X-ray examination without contrast
12.4
12.0
21
18
TK810
NOMESCO Finland
Hemofiltration
48.7
12.0
14
*
D64.9
ICD-10 Finland
Anaemia, unspecified
4.2
11.8
46
123
A02BC02
ATC
pantoprazole; systemic
2.5
11.8
216
1520
M32.9
ICD-10 Finland
Systemic lupus erythematosus, unspecified
31.4
11.8
15
5
Q61.2
ICD-10 Finland
Polycystic kidney, autosomal dominant
67.6
11.7
13
*
D86.1
ICD-10 Finland
Sarcoidosis of lymph nodes
24.0
11.7
16
7
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
3.6
11.6
55
175
KBV00
NOMESCO Finland
Insertion of stent into ureter
+∞
11.5
11
*
RS220
NOMESCO Finland
NA
36.5
11.4
14
*
I50.0
ICD-10 Finland
Congestive heart failure
4.9
11.3
37
83
A41.5
ICD-10 Finland
Sepsis due to other Gram-negative organisms
13.4
11.3
19
15
H02AB07
ATC
prednisone; oral
3.3
11.3
61
214
J01DB01
ATC
cefalexin; oral
2.8
11.1
257
2012
E11.2
ICD-10 Finland
Type 2 diabetes mellitus, with renal complications
9.4
11.0
22
25
212
Kela drug reimbursment
Gout
11.2
10.9
20
19
CJE20
NOMESCO Finland
Phakoemulsification with implantation of artificial lens in posterior chamber
2.5
10.8
106
540
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
2.7
10.7
86
389
N02AX02
ATC
tramadol; systemic, rectal
2.3
10.6
150
911
H02AB09
ATC
hydrocortisone; systemic
12.7
10.5
18
15
M32.1
ICD-10 Finland
Systemic lupus erythematosus with organ or system involvement
113.8
10.5
11
*
N11.8
ICD-10 Finland
Other chronic tubulo-interstitial nephritis
+∞
10.5
10
*
T86.1
ICD-10 Finland
Kidney transplant failure and rejection
+∞
10.5
10
*
N16.3*M10.0
ICD-10 Finland
Nephropathy caused by gout
+∞
10.5
10
*
PH1AE
NOMESCO Finland
Ultrasound examination of upper extremity veins
24.4
10.3
14
6
M05BX04
ATC
denosumab; parenteral
5.9
10.3
28
51
C07AG02
ATC
carvedilol; oral
4.6
10.2
35
83
A10BH05
ATC
linagliptin; oral
7.1
10.1
24
36
XF400
NOMESCO Finland
ECG with 12 standard connections
2.8
10.1
70
289
WX002
NOMESCO Finland
Sedation and analgesia
2.7
10.0
80
358
Z94.8
ICD-10 Finland
Other transplanted organ and tissue status
41.5
10.0
12
*
A04AA01
ATC
ondansetron; systemic, rectal
4.7
10.0
34
80
J01MA02
ATC
ciprofloxacin; systemic
2.3
9.9
132
771
A41.9
ICD-10 Finland
Sepsis, unspecified
7.2
9.8
23
34
GD1AD
NOMESCO Finland
Thorax CT examination
5.3
9.7
29
59
E10.2
ICD-10 Finland
Type 1 diabetes mellitus, With renal complications
56.9
9.7
11
*
329
Kela drug reimbursment
Lenalidomide
56.9
9.7
11
*
A46
ICD-10 Finland
Erysipelas
3.0
9.7
59
225
A10AE05
ATC
insulin detemir; parenteral
5.1
9.7
30
64
C08CA13
ATC
lercanidipine; oral
3.1
9.6
55
202
I70.2
ICD-10 Finland
Atherosclerosis of arteries of extremities
3.9
9.5
39
110
TPH30
NOMESCO Finland
Insertion of central venous catheter through periferal vein
18.3
9.5
14
8
A07AA09
ATC
vancomycin; oral
18.3
9.5
14
8
AA1AA
NOMESCO Finland
Head X-ray examination
31.1
9.5
12
*
WW400
NOMESCO Finland
Plasmaferesis
103.1
9.5
10
*
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
6.8
9.5
23
36
9732/3-C42.1
ICD-O-3
Plasma cell myeloma of bone marrow
22.5
9.4
13
6
EP1AE
NOMESCO Finland
Neck ultrasound examination
4.5
9.4
33
80
PG5RT
NOMESCO Finland
PTA of arterio-venous shunt for dialysis
+∞
9.4
9
*
TJA33
NOMESCO Finland
Percutaneous introduction of peritoneal dialysis catheter
+∞
9.4
9
*
N17.0
ICD-10 Finland
Acute renal failure with tubular necrosis
+∞
9.4
9
*
B01AA03
ATC
warfarin; systemic
2.6
9.4
79
366
J01MA14
ATC
moxifloxacin; systemic
3.6
9.3
43
134
N39.0
ICD-10 Finland
Urinary tract infection, site not specified
3.3
9.3
49
169
A04.7
ICD-10 Finland
Enterocolitis due to Clostridium difficile
14.3
9.3
15
11
JN3AA
NOMESCO Finland
Abdominal X-ray examination without contrast
5.0
9.2
29
63
M35.9
ICD-10 Finland
Systemic involvement of connective tissue, unspecified
12.0
9.2
16
14
WW200
NOMESCO Finland
Immunization
6.9
9.1
22
34
ZXA05
NOMESCO Finland
Left side
2.4
9.1
92
467
SPAT1148
SPAT
Treatment of chronic ulcer or burn
3.0
9.1
55
208
BBA40
NOMESCO Finland
Subtotal parathyroidectomy
37.9
9.1
11
*
UGC12
NOMESCO Finland
Flexible bronchoscopy
3.7
9.1
40
120
E11.9
ICD-10 Finland
Type 2 diabetes mellitus, without complications
2.4
9.0
86
426
C10AA05
ATC
atorvastatin; oral
2.1
8.8
134
821
I41.8*D86.8
ICD-10 Finland
Sarcoid myocarditis
51.5
8.7
10
*
N12
ICD-10 Finland
Tubulo-interstitial nephritis, not specified as acute or chronic
51.5
8.7
10
*
C02AC05
ATC
moxonidine; oral
5.5
8.7
25
49
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
8.7
80
389
C09CA01
ATC
losartan; oral
2.3
8.5
92
482
FJA10
NOMESCO Finland
Transvenous biopsy of right ventricle
92.5
8.5
9
*
N16.0*A02.2
ICD-10 Finland
Salmonella renal tubulo-interstitial disease
+∞
8.4
8
*
N16.0
ICD-10 Finland
Renal tubulo-interstitial disorders in infectious and parasitic diseases classified elsewhere
+∞
8.4
8
*
ZST00
NOMESCO Finland
Procedure related to previous procedure classified in chapter T
+∞
8.4
8
*
N25.0
ICD-10 Finland
Renal osteodystrophy
+∞
8.4
8
*
XPX99
NOMESCO Finland
Other diagnostic examination of periferal vessel
4.3
8.3
30
75
A02BC01
ATC
omeprazole; systemic
2.3
8.3
95
510
WX408
NOMESCO Finland
General anesthesy, balanced
2.2
8.3
95
511
N02AA05
ATC
oxycodone; systemic
2.8
8.3
57
233
E10.7
ICD-10 Finland
Type 1 diabetes mellitus, With multiple complications
8.5
8.2
17
21
E86
ICD-10 Finland
Volume depletion
8.5
8.2
17
21
XCK10
NOMESCO Finland
Photography of fundus of eye
3.4
8.2
40
131
N08.2*D89.80
ICD-10 Finland
Immunoglobulin A (IgA) nephropathy
34.3
8.1
10
*
A41.8
ICD-10 Finland
Other specified sepsis
13.5
7.9
13
10
RD210
NOMESCO Finland
NA
8.8
7.9
16
19
TNX10
NOMESCO Finland
Arthrocentesis, unspecified region, unspecified region
3.8
7.9
33
95
WW500
NOMESCO Finland
Blood transfusion
5.6
7.9
22
42
L97
ICD-10 Finland
Ulcer of lower limb, not elsewhere classified
5.9
7.8
21
38
A28
ICPC
Limited function/disability NOS
2.7
7.8
56
236
KH1AD
NOMESCO Finland
CT of urinary organs
8.4
7.7
16
20
ZXA00
NOMESCO Finland
Right side
2.2
7.7
99
557
E21.09
ICD-10 Finland
Other primary hyperparathyroidism
9.2
7.6
15
17
E83.51
ICD-10 Finland
Hypocalcemia
25.7
7.6
10
*
GD2SN
NOMESCO Finland
Lung ventilation SPECT
25.7
7.6
10
*
H26.3
ICD-10 Finland
Drug-induced cataract
25.7
7.6
10
*
C03DA01
ATC
spironolactone; oral
3.1
7.6
42
149
NH3AA
NOMESCO Finland
Foot and toes X-ray examination
3.5
7.5
35
110
N08.5*M32.1
ICD-10 Finland
Glomerular disorders in systemic lupus erythematosus
82.0
7.4
8
*
N17.8
ICD-10 Finland
Other acute renal failure
82.0
7.4
8
*
C07AB02
ATC
metoprolol; systemic
2.3
7.3
78
403
H05BX02
ATC
paricalcitol; systemic
+∞
7.3
7
*
K65.8
ICD-10 Finland
Other peritonitis
+∞
7.3
7
*
N165, T861
ICD-10 Finland
NA
+∞
7.3
7
*
PG5AC
NOMESCO Finland
Contrast examination of injection gate to artery or vein
+∞
7.3
7
*
KAS40
NOMESCO Finland
Excision of transplanted kidney
+∞
7.3
7
*
AA1AD
NOMESCO Finland
CT of head and brain
2.2
7.3
81
425
Z50.8
ICD-10 Finland
Care involving use of other rehabilitation procedures
3.5
7.2
33
103
103
Kela drug reimbursment
Diabetes, insulin-treated
2.1
7.2
96
546
GD1UN
NOMESCO Finland
Lung circulation SPECT
30.8
7.2
9
*
H26.2
ICD-10 Finland
Complicated cataract
20.6
7.2
10
5
TPH07
NOMESCO Finland
Cathetrisation of artery
2.8
7.1
45
175
WX892
NOMESCO Finland
Monitored bed care
3.3
7.1
35
115
NHQ40
NOMESCO Finland
Amputation of toe
10.4
7.1
13
13
UJF32
NOMESCO Finland
Coloscopy
2.1
7.0
90
501
S81.8
ICD-10 Finland
Open wound of other parts of lower leg
6.6
7.0
17
27
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.3
7.0
34
111
WX000
NOMESCO Finland
Monitoring vital functions without anesthesy
5.9
6.9
18
32
XG410
NOMESCO Finland
Flow-volume spirometry
4.0
6.9
26
69
NF1AA
NOMESCO Finland
Hip X-ray examination
3.3
6.8
33
108
N18
ICD-10 Finland
Chronic kidney disease
41.0
6.8
8
*
NJ3DA
NOMESCO Finland
Long bones of extremities X-ray examination
23.1
6.7
9
*
X59
ICD-10 Finland
Exposure to unspecified factor
2.4
6.7
63
303
J05AB01
ATC
aciclovir; systemic
2.2
6.7
70
358
NK4XE
NOMESCO Finland
Joint ultrasound examination not elsewhere classified
3.6
6.7
29
87
215
Kela drug reimbursment
Diabetes, non-insulin-treated
2.1
6.7
86
481
E21.3
ICD-10 Finland
Hyperparathyroidism, unspecified
12.6
6.6
11
9
Z01.8
ICD-10 Finland
Other specified special examinations
2.2
6.6
73
383
Z71.3
ICD-10 Finland
Dietary counselling and surveillance
3.9
6.6
26
72
K29.3
ICD-10 Finland
Chronic superficial gastritis
5.6
6.6
18
34
WZC10
NOMESCO Finland
Extensive specialist consultion with written report
4.0
6.6
25
67
SBB00
NOMESCO Finland
Fotograf of mouth and teeth
4.9
6.5
20
43
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.9
6.5
130
857
QDB10
NOMESCO Finland
Major dressing of wound of skin of lower limb
4.6
6.5
21
48
R11
ICD-10 Finland
Nausea and vomiting
3.4
6.5
30
95
PG5DE
NOMESCO Finland
Ultrasound examination of injection gate to artery or vein with Doppler method
71.3
6.4
7
*
K65.9
ICD-10 Finland
Peritonitis, unspecified
71.3
6.4
7
*
K06.19
ICD-10 Finland
Gingival hyperplasia UNS
71.3
6.4
7
*
SAA04
NOMESCO Finland
Special inverstigation of mouth
4.0
6.4
24
63
M01AE01
ATC
ibuprofen; systemic, rectal
0.5
6.4
192
2336
A10AB04
ATC
insulin lispro; parenteral (insulins and analog. for injection, fast-acting)
5.7
6.4
17
31
ZXM00
NOMESCO Finland
Intraoperative use of ultrasonographic imaging
11.4
6.3
11
10
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.7
6.3
44
182
R80
ICD-10 Finland
Isolated proteinuria
18.5
6.3
9
5
WX610
NOMESCO Finland
Patient controlled analgesia
18.5
6.3
9
5
WX882
NOMESCO Finland
High dependency care
7.3
6.3
14
20
N03AX16
ATC
pregabalin; oral
2.1
6.3
78
426
R4190
NOMESCO Finland
Nutritional therapy
5.2
6.3
18
36
A12AA06
ATC
calcium lactate gluconate; oral
+∞
6.3
6
*
Y83.0
ICD-10 Finland
Surgical operation with transplant of whole organ as the cause of abnormal reaction of the patient, or of later complication, without mention of misadventure at the time of the procedure
+∞
6.3
6
*
N16.3*E72.0
ICD-10 Finland
Renal tubulo-interstitial disorders in cystinosis
+∞
6.3
6
*
N16.4
ICD-10 Finland
Renal tubulo-interstitial disorders in systemic connective tissue disorders
+∞
6.3
6
*
M10.3
ICD-10 Finland
Gout due to impairment of renal function
+∞
6.3
6
*
187
Kela drug reimbursment
MPA
+∞
6.3
6
*
KA9AE
NOMESCO Finland
Ultrasound examination transplanted kidney
+∞
6.3
6
*
N16.1
ICD-10 Finland
Renal tubulo-interstitial disorders in neoplastic diseases
+∞
6.3
6
*
V03AE04
ATC
calcium acetate and magnesium carbonate; systemic
+∞
6.3
6
*
H47.1
ICD-10 Finland
Papilloedema, unspecified
+∞
6.3
6
*
G05.8*M32.1
ICD-10 Finland
Encephalitis in systemic lupus erythematosus
+∞
6.3
6
*
WX100
NOMESCO Finland
Conjunctival surface anesthesia
2.7
6.3
43
176
QDB05
NOMESCO Finland
Revision of wound of skin of lower limb
6.5
6.2
15
24
WX402
NOMESCO Finland
General anaesthesia
2.4
6.2
58
277
TGC00
NOMESCO Finland
Bronchial lavation
6.0
6.2
16
28
A06AD11
ATC
lactulose; oral
2.5
6.2
51
230
N02BE01
ATC
paracetamol; systemic, rectal
2.2
6.2
260
2215
XF655
NOMESCO Finland
Measurement of heart muscle perfusion with exercise
5.1
6.2
18
37
A10AB01
ATC
insulin (human); parenteral (insulins and analog. for injection, fast-acting)
5.1
6.2
18
37
RS221
NOMESCO Finland
NA
8.9
6.1
12
14
UKC02
NOMESCO Finland
Cystoscopy
2.3
6.1
56
269
RS222
NOMESCO Finland
NA
10.3
6.1
11
11

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
202
160
29.52
229.95
9.7
1.8
127.5
64.5
ng/l
8.62
185
141
241
294
25.54
212.46
20.1
2.8
1.1
1.0
mmol/l
7.47
235
269
168
347
8.57
87.53
7.0
1.8
22.6
23.7
%
0.47
147
295
173
399
7.77
80.08
6.8
1.8
11.6
13.8
umol/l
3.99
167
366
129
234
8.26
74.45
13.3
2.2
—
—
—
0
0
126
224
8.34
74.03
13.5
2.1
0.8
2.2
mmol/l
3.77
102
181
88
101
11.40
73.75
12.4
1.6
22.9
24.7
mmol/l
4.45
83
89
75
68
13.86
73.61
8.8
4.1
90.8
30.0
mg/l
0.48
55
56
75
68
13.86
73.61
8.8
4.1
599.6
42.5
mg/l
0.63
54
56
118
197
8.63
73.27
13.0
7.4
—
—
—
0
0
214
693
6.61
66.95
6.4
2.5
410.6
7741.6
umol/l
3.26
199
592
76
87
10.95
63.38
3.0
1.8
1.6
1.5
g/l
0.33
70
75
294
1330
9.78
62.03
35.3
5.5
1.2
1.2
mmol/l
0.92
260
1125
61
53
13.80
61.07
9.2
4.8
—
—
—
0
0
265
1152
6.83
56.16
16.2
4.3
34.6
35.7
g/l
2.46
258
1071
273
1220
7.21
55.99
27.5
5.0
1.2
1.2
mmol/l
3.47
265
1096
97
172
7.48
55.92
5.5
2.3
—
—
—
0
0
214
795
5.54
54.12
8.4
3.1
365.0
217.9
mg/l
0.25
192
496
153
431
5.63
53.95
5.2
2.8
0.8
0.8
mmol/l
0.26
146
406
214
797
5.52
53.89
22.3
3.1
7.4
7.4
ph
1.17
48
141
41
22
21.05
52.58
2.4
2.0
—
—
—
0
0
120
279
6.09
52.33
3.6
2.3
1.8
1.8
%
0.09
114
245
217
841
5.35
51.36
9.9
3.7
28.1
6.9
mg/mmol
5.44
196
505
102
208
6.57
50.95
5.8
2.4
63.9
66.8
g/l
2.77
96
190
50
43
13.45
50.08
2.0
1.3
97.9
118.7
u/ml
—
13
10
214
837
5.18
49.60
8.6
2.9
6.3
7.9
mmol/l
7.86
207
664
52
49
12.34
49.15
2.1
1.3
—
—
—
0
0
223
908
5.21
48.91
13.4
5.3
—
—
—
0
0
161
512
5.06
48.20
6.4
2.3
505.1
582.2
mosm/kgh2o
4.12
154
425
36
18
22.24
47.46
2.2
2.2
—
—
—
0
0
37
20
20.63
47.17
2.3
2.5
—
—
—
0
0
205
805
4.88
46.46
9.3
2.8
16.5
139.3
e6/l
0.87
190
610
46
39
13.48
46.39
7.2
1.4
—
—
—
0
0
36
19
21.07
46.36
1.1
1.3
—
—
—
0
0
96
201
6.26
46.34
3.2
2.3
69.7
72.2
e9/l
0.14
71
162
92
187
6.37
45.76
9.4
2.1
5.1
4.4
kpa
1.48
87
181
191
731
4.67
44.25
8.6
2.7
0.3
0.5
e6/l
0.57
171
535
54
63
10.00
43.84
2.5
2.0
—
—
—
0
0
82
158
6.52
42.90
7.0
2.6
4.9
5.2
kpa
2.58
76
144
81
156
6.50
42.37
7.1
2.6
7.4
7.4
ph
0.32
17
13
47
48
11.20
41.92
1.7
1.1
222.8
314.1
u/ml
0.67
36
27
216
940
4.54
41.28
11.1
3.2
38.7
83.3
e6/l
1.14
193
656
182
713
4.33
39.89
8.2
2.6
—
—
—
0
0
91
215
5.41
37.95
5.2
2.4
9.4
10.3
g/l
0.85
86
188
252
1293
4.64
36.87
15.0
5.4
2.8
2.8
%
0.04
247
1199
30
19
17.22
35.28
1.8
1.2
—
—
—
0
0
174
711
3.96
34.84
8.5
3.7
—
—
—
0
0
258
1379
4.58
34.84
14.1
5.3
0.0
0.0
e9/l
1.63
242
1196
57
93
7.16
34.72
7.6
2.9
0.8
0.2
g/l
1.96
37
37
52
77
7.79
34.56
1.7
1.2
—
—
—
0
0
257
1377
4.52
34.40
14.2
5.2
0.6
0.6
e9/l
2.46
243
1185
199
898
3.92
34.22
7.8
3.2
2.3
2.4
mmol/l
0.28
188
785
258
1405
4.44
33.27
14.2
5.4
1.6
2.0
e9/l
2.72
247
1251
226
1126
3.99
33.17
6.8
2.5
188.2
126.4
ug/l
4.44
213
1019
126
428
4.08
32.60
7.1
2.6
1.8
1.9
e6/l
0.09
87
240
97
275
4.53
31.98
3.0
1.5
—
—
—
0
0
257
1423
4.27
31.68
15.4
5.5
0.2
0.2
e9/l
0.02
245
1254
104
326
4.15
29.79
2.9
1.5
—
—
—
0
0
39
49
8.86
29.60
7.5
2.2
—
—
—
0
0
73
175
5.04
29.47
3.9
1.6
0.9
1.8
g/l
1.60
66
160
66
147
5.33
28.99
9.6
6.5
23.5
25.0
mmol/l
2.04
66
147
151
642
3.43
26.97
2.6
2.0
3.3
3.1
mg/l
0.37
134
545
264
1596
3.90
26.11
21.0
8.7
4.4
4.1
e9/l
1.28
249
1400
55
117
5.41
25.31
8.5
2.6
—
—
—
0
0
286
1859
4.34
24.55
14.4
3.8
—
—
—
0
0
210
1131
3.23
24.52
14.9
8.9
1.3
1.2
inr
0.23
51
333
34
48
7.76
23.33
12.0
1.8
—
—
—
0
0
26
26
10.74
23.22
2.7
1.6
—
—
—
0
0
26
26
10.74
23.22
2.7
1.6
—
—
—
0
0
26
26
10.74
23.22
2.7
1.6
—
—
—
0
0
26
26
10.74
23.22
2.7
1.6
—
—
—
0
0
156
726
3.12
23.20
5.0
2.6
—
—
—
0
0
105
392
3.43
22.54
3.0
2.0
—
—
—
0
0
269
1751
3.54
21.39
9.6
3.8
347.9
234.4
e6/l
—
7
29
33
51
7.06
20.86
3.0
2.1
17.1
15.9
%
0.62
23
20
30
42
7.74
20.69
2.7
2.0
—
—
—
0
0
218
1278
2.96
20.48
8.0
3.2
0.0
0.0
estimate
0.00
46
240
21
19
11.71
19.95
1.2
1.2
—
—
—
0
0
238
1475
3.03
19.95
10.3
6.0
10.2
11.4
umol/l
1.60
231
1398
218
1295
2.89
19.68
7.9
3.3
0.0
0.0
estimate
0.50
42
230
216
1281
2.87
19.49
11.7
4.5
0.0
0.0
estimate
0.50
44
244
300
2145
4.32
19.48
21.3
7.2
80.7
77.9
u/l
0.48
291
1993
102
409
3.13
19.10
3.0
1.8
—
—
—
0
0
20
18
11.74
19.05
1.9
2.1
—
—
—
0
0
250
1634
2.99
18.20
13.3
4.4
6.7
6.7
mmol/l
0.21
239
1523
161
844
2.72
18.12
4.6
2.9
3538.6
1001.7
ng/l
6.16
148
716
24
9
28.54
18.07
2.0
1.7
—
—
—
0
0
139
682
2.75
17.76
15.8
6.4
—
—
—
0
0
63
197
3.70
17.44
9.7
3.1
—
—
—
0
0
61
190
3.69
16.97
5.0
4.3
0.6
0.3
%
1.09
23
37
30
52
6.23
16.96
2.5
1.9
131.1
129.2
g/l
0.12
23
35
66
219
3.50
16.67
5.5
4.3
0.6
1.1
%
1.12
31
66
63
203
3.58
16.64
5.4
4.5
0.1
0.1
%
0.58
29
55
29
50
6.25
16.47
1.2
1.6
—
—
—
0
0
56
169
3.77
16.28
1.8
1.4
—
—
—
0
0
189
1112
2.57
16.28
2.4
1.9
102.8
98.0
pmol/l
0.61
107
554
87
346
3.03
16.27
1.5
1.3
720.0
492.1
titre
0.48
25
86
80
311
3.05
15.51
2.3
1.5
—
—
—
0
0
105
478
2.73
15.16
2.0
1.7
1173.5
1168.1
nmol/l
0.02
88
352
14
0
+∞
14.69
11.1
0.0
5.1
—
mmol/l
—
14
0
157
878
2.46
14.66
4.3
2.3
—
—
—
0
0
19
23
8.69
14.64
3.5
3.5
—
—
—
0
0
119
586
2.58
14.59
6.8
3.3
—
—
—
0
0
130
669
2.52
14.51
3.7
2.2
—
—
—
0
0
25
43
6.19
14.20
15.6
1.3
69.9
63.2
%
0.76
25
43
20
27
7.81
14.12
1.4
1.2
—
—
—
0
0
195
1218
2.40
14.01
24.5
8.9
0.0
0.0
e9/l
0.09
169
1003
25
44
6.05
13.88
1.5
1.2
—
—
—
0
0
279
2062
2.94
13.87
10.3
3.8
19.3
11.2
mm/h
10.02
271
1872
28
57
5.26
13.35
10.1
2.6
1.6
2.7
mmol/l
1.43
17
39
28
57
5.26
13.35
10.1
2.6
9.0
8.3
kpa
1.41
28
57
28
57
5.26
13.35
10.1
2.6
4.8
5.1
kpa
1.26
28
57
17
7
25.45
12.58
2.8
3.9
—
—
—
0
0
65
253
2.94
12.40
19.7
3.5
—
—
—
0
0
53
187
3.17
11.97
5.3
4.5
0.0
0.2
%
0.57
25
40
76
328
2.69
11.92
1.9
1.4
—
—
—
0
0
14
15
9.69
11.73
4.6
2.8
3204.7
797.7
u/ml
0.53
14
15
23
44
5.53
11.71
1.1
1.3
—
—
—
0
0
196
1295
2.21
11.46
6.2
3.8
—
—
—
0
0
14
16
9.08
11.19
5.6
1.3
11.4
10.9
%
0.15
14
16
149
890
2.20
11.16
4.7
2.4
58.9
56.5
u/l
0.41
141
819
120
660
2.26
10.98
2.0
1.5
19.9
20.5
nmol/l
0.11
114
547
109
577
2.31
10.92
3.1
1.6
1.4
1.1
mg/l
0.80
90
441
142
838
2.19
10.91
2.3
2.0
114.9
245.9
u/l
1.02
136
785
104
543
2.32
10.73
3.5
1.4
2.6
2.5
g/l
0.06
71
329
30
78
4.12
10.64
6.0
3.6
—
—
—
0
0
37
112
3.58
10.61
2.9
2.0
6.4
4.0
ug/l
0.17
37
99
10
0
+∞
10.47
2.0
0.0
—
—
—
0
0
70
313
2.56
10.11
8.4
7.7
-0.1
1.2
mmol/l
0.94
57
257
41
142
3.15
9.50
7.4
9.7
22.8
24.6
mmol/l
1.79
41
135
20
42
5.00
9.18
4.7
3.6
58.0
56.5
%
0.16
20
42
14
21
6.91
8.96
1.3
1.2
—
—
—
0
0
97
526
2.18
8.93
6.3
3.5
439.1
297.1
ng/l
0.26
90
405
43
160
2.93
8.80
3.2
3.5
4.2
4.6
pmol/l
1.50
36
139
19
40
4.97
8.69
3.5
3.3
3.8
4.5
e9/l
0.65
19
40
40
148
2.93
8.26
11.1
9.1
—
—
—
0
0
17
34
5.21
8.23
2.1
1.7
90.0
89.5
%
0.10
17
34
47
192
2.68
8.08
2.3
1.7
—
—
—
0
0
65
313
2.33
7.89
6.9
3.0
8.0
7.5
umol/l
0.13
60
278
25
71
3.72
7.85
1.5
1.3
9.2
2.6
u/ml
—
5
10
20
48
4.36
7.84
1.1
1.1
14.5
50.4
u/l
0.77
20
43
13
21
6.40
7.77
1.5
2.1
468.0
467.3
e6/l
—
5
10
14
25
5.80
7.60
2.0
2.3
1.0
0.9
e9/l
—
8
12
12
19
6.51
7.29
8.0
2.9
—
—
—
0
0
13
23
5.84
7.12
1.0
1.1
—
—
—
0
0
115
721
1.90
6.83
7.7
2.9
—
—
—
0
0
26
84
3.27
6.74
1.1
1.3
—
2.3
—
0
8
302
2597
2.42
6.57
9.7
5.8
41.6
39.9
mmol/mol
1.78
294
2407
316
2780
2.86
6.45
50.0
12.7
16.7
23.1
mg/l
6.34
292
2164
13
26
5.16
6.27
1.8
2.1
33.1
33.2
pg
0.02
13
26
6
0
+∞
6.27
5.2
0.0
—
—
—
0
0
16
39
4.26
6.16
1.3
1.2
—
—
—
0
0
155
1093
1.77
6.12
5.7
3.6
100.4
38.1
ng/l
0.64
127
790
15
35
4.44
6.08
1.6
1.2
—
—
—
0
0
13
27
4.97
6.02
7.9
3.0
—
—
—
0
0
35
143
2.61
6.00
1.4
1.2
—
—
—
0
0
15
36
4.31
5.88
1.8
1.2
4.2
10.7
u/ml
—
9
14
69
381
2.02
5.85
1.2
1.3
—
—
—
0
0
84
504
1.88
5.57
4.0
3.1
2.5
2.5
mmol/l
1.41
74
446
5
0
+∞
5.22
4.0
0.0
1.6
—
g/l
—
5
0
87
541
1.82
5.11
1.6
1.8
439.1
444.7
pmol/l
0.07
77
446
12
27
4.57
5.07
22.8
9.3
7.0
6.7
mmol/l
0.09
12
20
24
88
2.86
5.05
1.5
1.1
—
—
—
0
0
12
29
4.25
4.66
1.5
3.3
—
—
—
0
0
63
366
1.88
4.56
36.5
22.8
1.7
1.3
inr
—
7
48
12
30
4.11
4.47
1.2
1.2
—
—
—
0
0
20
71
2.93
4.47
1.2
1.1
—
—
—
0
0
15
45
3.44
4.37
1.4
1.5
—
—
—
0
0
10
22
4.65
4.33
2.9
2.0
—
—
—
0
0
7
6
11.87
4.29
1.0
1.0
1565.3
1603.0
miu/ml
—
7
6
42
216
2.08
4.29
10.0
3.1
—
—
—
0
0
316
2877
2.34
4.25
58.3
14.9
139.6
139.7
mmol/l
0.67
310
2796
13
36
3.71
4.24
1.0
1.0
—
—
—
0
0
48
261
1.98
4.22
2.5
2.1
0.2
0.2
g/l
0.57
43
237
316
2883
2.31
4.12
60.9
14.9
4.1
4.0
mmol/l
5.55
309
2798
243
2056
1.63
4.03
5.0
3.8
15.0
14.9
pmol/l
0.24
236
1834
11
28
4.03
4.01
1.3
1.2
—
—
—
0
0
43
232
1.98
3.86
1.9
1.3
—
—
—
0
0
24
102
2.46
3.83
2.7
1.7
—
—
—
0
0
11
29
3.89
3.83
1.5
1.2
127464.0
39216.3
e6/l
—
5
17
11
30
3.76
3.67
1.5
1.2
219.2
1986.5
e6/l
—
6
21
97
676
1.61
3.64
8.9
3.5
0.0
0.0
estimate
0.50
39
235
10
26
3.93
3.54
1.7
1.2
—
—
—
0
0
35
181
2.04
3.54
8.1
5.0
—
—
—
0
0
90
622
1.61
3.48
9.7
4.5
—
—
—
0
0
143
1101
1.51
3.41
2.5
2.0
—
—
—
0
0
9
18
5.10
3.39
1.8
1.0
—
—
—
0
0
8
15
5.43
3.21
1.9
1.7
0.0
0.2
e9/l
—
8
15
7
11
6.47
3.20
1.6
1.2
—
—
—
0
0
12
39
3.15
3.12
1.5
1.4
—
—
—
0
0
6
8
7.61
3.06
1.3
1.4
—
—
—
0
0
13
45
2.96
3.06
1.2
1.4
0.3
0.6
g/l
—
7
36
34
185
1.93
3.00
1.9
2.7
4.6
3.9
e9/l
0.71
26
140
6
9
6.76
2.88
1.3
1.1
—
—
—
0
0
111
835
1.49
2.87
5.2
3.9
—
—
—
0
0
9
23
3.99
2.79
1.3
1.2
—
—
—
0
0
50
315
1.69
2.75
1.9
2.5
159.4
134.8
ug/g
0.23
40
244
13
48
2.78
2.75
2.1
1.2
—
—
—
0
0
6
10
6.08
2.71
1.3
1.2
—
—
—
0
0
10
32
3.19
2.66
1.0
1.3
—
—
—
0
0
8
20
4.07
2.58
1.1
1.3
275.1
274.0
mosm/kgh2o
—
8
12
50
322
1.65
2.54
1.4
1.3
—
—
—
0
0
22
109
2.09
2.52
2.9
2.5
—
—
—
0
0
24
125
1.99
2.42
1.4
1.2
—
—
—
0
0
9
27
3.39
2.41
1.6
1.2
—
—
—
0
0
19
92
2.13
2.32
1.6
1.6
—
—
—
0
0
317
2988
1.87
2.31
28.3
10.0
23.8
26.6
u/l
3.25
312
2869
310
2904
1.74
2.30
42.1
12.3
—
—
—
0
0
7
18
3.95
2.26
1.6
1.1
—
—
—
0
0
98
750
1.43
2.25
2.1
1.6
1.5
1.4
mmol/l
0.61
91
614
12
48
2.55
2.21
3.1
3.6
0.9
0.9
nmol/l
—
7
41
11
42
2.67
2.20
1.0
1.1
—
—
—
0
0
37
229
1.69
2.19
2.5
2.5
18.6
6.6
ug/l
0.46
32
201
8
24
3.39
2.19
2.5
1.4
—
—
—
0
0
99
763
1.42
2.18
1.5
1.4
—
—
—
0
0
5
10
5.06
2.07
1.4
1.4
—
—
—
0
0
223
1979
1.37
2.00
5.4
3.8
—
—
—
0
0
8
27
3.01
1.95
1.4
1.0
—
—
—
0
0
6
17
3.57
1.84
1.2
1.1
1.9
1.8
mmol/l
—
6
17
25
149
1.73
1.72
10.4
3.3
—
—
—
0
0
31
197
1.63
1.70
1.1
1.2
—
—
—
0
0
273
2532
1.39
1.66
6.0
4.6
2.3
2.4
mu/l
0.11
261
2275
296
2787
1.47
1.62
6.5
4.5
4.5
4.6
mmol/l
2.35
290
2565
5
14
3.61
1.62
1.0
1.1
—
—
—
0
0
294
2766
1.46
1.61
6.5
4.4
1.4
1.5
mmol/l
5.30
287
2522
7
26
2.73
1.59
2.6
2.6
—
—
—
0
0
7
26
2.73
1.59
1.6
1.3
—
—
—
0
0
6
20
3.03
1.59
1.5
1.3
94066.7
214433.1
e6/l
—
6
13
286
2681
1.41
1.56
5.9
4.0
1.6
1.3
mmol/l
7.90
277
2429
16
86
1.90
1.53
8.6
4.1
—
—
—
0
0
272
2532
1.37
1.52
50.6
14.3
36.9
40.0
%
5.74
191
1813
6
21
2.89
1.51
1.5
1.1
28.2
34.4
mg/l
—
6
16
72
561
1.36
1.46
7.7
3.5
1.0
1.0
kg/l
0.22
11
85
5
16
3.16
1.44
1.4
1.3
—
—
—
0
0
5
16
3.16
1.44
1.4
2.6
—
—
—
0
0
5
16
3.16
1.44
1.0
1.1
—
—
—
0
0
8
161
0.48
1.40
1.5
1.4
—
—
—
0
0
48
355
1.41
1.33
1.3
1.2
—
—
—
0
0
75
601
1.32
1.27
1.3
1.2
0.6
1.0
u/ml
1.03
13
179
8
36
2.25
1.25
1.0
1.3
—
—
—
0
0
5
19
2.65
1.22
1.6
1.4
—
—
—
0
0
8
38
2.13
1.19
1.9
1.3
—
—
—
0
0
35
252
1.43
1.14
2.3
1.5
—
—
—
0
0
15
242
0.60
1.11
1.2
1.3
—
—
—
0
0
7
35
2.02
1.00
1.1
1.1
—
—
—
0
0
7
36
1.96
0.97
1.3
1.3
—
—
—
0
0
296
2839
1.32
0.97
6.8
5.0
2.5
2.8
mmol/l
3.48
288
2592
6
28
2.16
0.92
1.8
1.4
—
—
—
0
0
319
3100
1.45
0.90
67.1
19.2
232.8
245.2
e9/l
2.58
313
3012
6
29
2.09
0.89
1.7
1.6
—
—
—
0
0
319
3102
1.44
0.88
66.7
19.1
30.4
30.4
pg
0.05
313
3053
319
3102
1.44
0.88
66.7
19.1
92.4
91.1
fl
3.89
313
3054
319
3103
1.43
0.86
67.0
19.2
4.2
4.5
e12/l
12.66
312
3005
319
3104
1.43
0.85
67.1
19.2
7.0
6.7
e9/l
1.22
313
3010
319
3104
1.43
0.85
67.4
19.3
126.8
136.8
g/l
17.44
313
3052
11
66
1.69
0.79
1.0
1.3
—
300.2
—
0
31
24
175
1.40
0.77
3.9
2.4
—
—
—
0
0
26
194
1.37
0.74
1.3
1.4
—
—
—
0
0
24
177
1.38
0.73
1.4
1.3
—
48.6
—
0
11
7
41
1.72
0.70
5.7
2.5
4.3
4.0
mmol/l
—
7
41
7
41
1.72
0.70
5.7
2.5
103.7
105.4
mmol/l
—
7
41
7
41
1.72
0.70
2.3
3.0
—
—
—
0
0
7
41
1.72
0.70
5.7
2.5
—
—
—
0
0
9
59
1.54
0.69
5.0
2.0
—
—
—
0
0
87
983
0.85
0.66
4.5
2.9
—
—
—
0
0
5
29
1.73
0.64
1.0
1.4
—
—
—
0
0
15
104
1.46
0.63
9.3
4.5
—
—
—
0
0
0
23
0.00
0.58
0.0
1.2
—
—
—
0
0
6
37
1.63
0.56
1.2
1.1
1.4
1.5
g/l
—
6
31
54
467
1.19
0.50
1.2
1.3
93.8
29.8
iu/ml
0.70
17
155
0
16
0.00
0.41
0.0
1.1
—
—
—
0
0
8
59
1.36
0.41
1.1
1.2
—
—
—
0
0
17
132
1.30
0.41
2.2
2.6
—
—
—
0
0
8
60
1.34
0.40
2.6
1.6
—
—
—
0
0
5
34
1.48
0.40
1.4
2.5
—
—
—
0
0
0
19
0.00
0.39
0.0
1.1
—
2.3
—
0
9
5
36
1.39
0.38
1.6
1.2
—
—
—
0
0
280
2736
1.13
0.35
7.6
4.6
6.0
6.0
mmol/l
0.43
257
2489
7
97
0.72
0.31
2.1
1.3
—
—
—
0
0
15
121
1.25
0.29
1.1
1.1
—
—
—
0
0
117
1108
1.09
0.27
4.5
5.0
2.3
2.6
ug/l
0.28
107
978
5
72
0.69
0.26
1.6
1.1
10.7
10.9
u/l
—
5
57
15
124
1.22
0.24
2.6
3.7
1972.8
2069.8
u/ml
0.01
15
109
0
11
0.00
0.21
0.0
1.1
—
205.0
—
0
11
0
11
0.00
0.21
0.0
1.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
10
0.00
0.21
0.0
3.0
—
43.4
—
0
5
0
10
0.00
0.21
0.0
2.9
—
—
—
0
0
11
89
1.24
0.21
1.2
1.7
38.7
39.4
nmol/l
0.06
11
84
8
71
1.13
0.16
2.0
1.3
—
—
—
0
0
9
78
1.16
0.15
2.1
1.5
245.0
265.9
mu/l
—
9
73
15
171
0.87
0.15
1.0
1.2
—
—
—
0
0
8
96
0.83
0.14
2.0
1.3
—
—
—
0
0
8
96
0.83
0.14
2.0
1.3
—
—
—
0
0
8
96
0.83
0.14
2.0
1.3
—
—
—
0
0
20
221
0.90
0.13
1.3
1.4
—
—
—
0
0
6
72
0.83
0.07
1.0
1.1
—
—
—
0
0
29
280
1.04
0.03
1.2
1.7
—
—
—
0
0
31
300
1.04
0.03
2.3
4.5
3.4
41.7
ug/l
0.87
24
258
65
648
1.00
0.00
2.5
3.0
1.0
0.7
ug/l
1.05
42
421
45
451
1.00
0.00
1.2
1.3
8.9
8.8
u/ml
—
10
177
6
64
0.94
0.00
1.2
1.2
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
8
89
0.90
0.00
2.0
1.3
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
2.1
—
0
6
0
6
0.00
0.00
0.0
3.7
—
—
—
0
0
0
5
0.00
0.00
0.0
2.4
—
1.2
—
0
5
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

Association

Association between endpoint N14_RENALTUBULOINOTH and mortality.

Females

Parameter HR [95% CI] p-value
N14_RENALTUBULOINOTH 2.925 [2.31, 3.71] < 0.001
Birth year 0.995 [0.99, 1.0] 0.263

During the follow-up period (1.1.1998 — 31.12.2019), 286 out of 748 females with N14_RENALTUBULOINOTH died.

Males

Parameter HR [95% CI] p-value
N14_RENALTUBULOINOTH 2.812 [2.18, 3.63] < 0.001
Birth year 0.984 [0.97, 0.99] 0.001

During the follow-up period (1.1.1998 — 31.12.2019), 319 out of 809 males with N14_RENALTUBULOINOTH died.

Mortality risk

Mortality risk for people of age

years, who have N14_RENALTUBULOINOTH.

N-year risk Females Males
1 0.25% 0.476%
5 1.735% 2.944%
10 4.3% 7.322%
15 8.306% 13.33%
20 14.035% 21.922%

Relationships between endpoints

Index endpoint: N14_RENALTUBULOINOTH – Renal tubulo-interstitial disorders in diseases classified elsewhere

GWS hits: -

Endpoint
Case Overlap
Survival Analysis
Genetic Correlations
Genetic Signals
N (Jaccard index)
HR [CI]
rg [CI]
Hits
Coloc Hits
FinRegistry
FinnGen
FinRegistry
FinnGen
FinnGen
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