Atrial septal defect, secundum type

Q17_ATRIAL_SEPTAL_DEFECT_SECUNDUM_TYPE

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

519972

1. Apply sex-specific rule

None

519972

2. Check conditions

None

519972

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Q21.10
  • Hospital discharge: ICD-9 7455A
  • Hospital discharge: ICD-8 74642
  • Cause of death: ICD-10 Q21.10
  • Cause of death: ICD-9 7455A
  • Cause of death: ICD-8 74642

2 out of 7 registries used, show all original rules.

1104

4. Check minimum number of events

None

1104

5. Include endpoints

None

1104

6. Filter based on genotype QC (FinnGen only)

1058

Control definitions (FinnGen only)

Controls for this endpoint are individuals that are not cases.

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded (different definition than used in FinnGen).

-FinnGen-

Key figures

All Female Male
Number of individuals 1058 707 351
Unadjusted period prevalence (%) 0.22 0.25 0.16
Median age at first event (years) 21.27 22.69 18.41

-FinnGen-

Age distribution of first events

-FinnGen-

Year distribution of first events

-FinnGen-

Cumulative Incidence Function

CodeWAS

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
1104
Matched controls
11001
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
FM1BE
NOMESCO Finland
Cardiac ultrasound examination through oesophagus
25.5
307.7
436
275
Q21.10
ICD-10 Finland
Persistent ostium secundum
4503599627370496.0
307.7
833
*
FFC22
NOMESCO Finland
Percutaneous transluminal closure of ostium secundum type ASD
180.8
307.7
182
12
XF620
NOMESCO Finland
Examination of circulation with color method
104.7
251.0
130
14
74642
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium secundum
+∞
250.5
231
*
FXA00
NOMESCO Finland
Total cardiopulmonary bypass in normothermia or moderate hypothermia at concurrent surgical procedure
14.7
220.6
214
177
FM1EE
NOMESCO Finland
Extensive structural and functional ultrasound examination of heart
6.6
216.7
554
1451
Q21.11
ICD-10 Finland
Paten or persistent foramen ovale
29.8
204.5
139
53
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
7.0
202.4
409
848
Q21.19
ICD-10 Finland
Atrial septal defect NOS
290.8
194.3
193
8
Q21.00
ICD-10 Finland
Multiple ventricular septal defect
45.6
167.6
100
24
B01AA03
ATC
warfarin; systemic
6.5
154.7
313
635
FFC00
NOMESCO Finland
Suture of ostium secundum type ASD
+∞
154.7
145
*
TFC00
NOMESCO Finland
Catheterisation of right atrium or ventricle
40.9
153.4
94
25
Q21.09
ICD-10 Finland
Ventricular septal defect NOS
34.4
143.1
92
29
201
Kela drug reimbursment
Chronic cardiac insufficiency
11.5
143.1
158
157
7455A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ostium secundum type atrial septal defect
+∞
126.4
119
*
I48
ICD-10 Finland
Atrial fibrillation and flutter
5.0
111.4
294
740
XF400
NOMESCO Finland
ECG with 12 standard connections
4.4
103.5
347
1048
Q21.08
ICD-10 Finland
Other specifed ventricular septal defect
15.5
103.0
92
64
C01AA05
ATC
digoxin; systemic
8.0
96.9
141
198
FM1DE
NOMESCO Finland
Doppler ultrasound examination of heart
5.6
95.0
205
430
XF404
NOMESCO Finland
Ambulatory ECG
5.3
85.2
195
429
TFP20
NOMESCO Finland
Cardiodefibrillation
6.9
85.0
141
228
GD1AA
NOMESCO Finland
Thorax X-ray examination
3.3
82.3
607
2981
31
HP
Congenital heart failure surgery
117.5
81.1
87
8
5253
FHL
Cardiac lung machine
48.9
80.2
47
10
5205
FHL
ASD blockage, secondary defect
+∞
74.7
71
*
FM2CE, ,
NOMESCO Finland
6.6
69.9
120
200
TPH15
NOMESCO Finland
Insertion of central venous catheter through external or internal jugular vein
4.7
66.3
171
412
207
Kela drug reimbursment
Chronic arrhythmias
4.2
63.2
193
529
I36.1
ICD-10 Finland
Nonrheumatic tricuspid (valve) insufficiency
14.6
61.4
56
40
C03CA01
ATC
furosemide; systemic
3.2
60.5
320
1254
Q22.1
ICD-10 Finland
Congenital pulmonary valve stenosis
28.2
60.2
41
15
GD1UA
NOMESCO Finland
Thorax X-ray examination outside radiological department
3.3
56.6
262
945
FM1DG
NOMESCO Finland
Very extensive MRI examination of heart with high intesity magnet
10.1
55.9
65
68
TPH07
NOMESCO Finland
Cathetrisation of artery
3.8
55.9
200
611
FN1AC
NOMESCO Finland
Angiography of heart and/or coronary arteries
3.3
55.2
249
883
61
HP
Catheterization and pressure measurement of the left side of the heart
17.0
54.8
46
28
WX872
NOMESCO Finland
Intensive care
6.3
52.9
93
158
I35.1
ICD-10 Finland
Aortic (valve) insufficiency
6.4
50.1
87
146
XFP20
NOMESCO Finland
Check up of cardiac pacemaker
5.7
49.7
98
186
Q25.1
ICD-10 Finland
Coarctation of aorta
16.1
48.6
42
27
K78
ICPC
Atrial fibrillation/flutter
5.3
47.8
102
208
XF402
NOMESCO Finland
ECG with work load test
3.9
45.5
146
411
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
6.1
44.6
81
142
Q21.9
ICD-10 Finland
Congenital malformation of cardiac septum, unspecified
100.0
44.1
48
5
XFE00
NOMESCO Finland
Epicardial ultrasonography
9.6
42.8
51
55
WX408
NOMESCO Finland
General anesthesy, balanced
2.5
42.2
387
1964
C07AB07
ATC
bisoprolol; oral
2.4
41.9
464
2560
I50.9
ICD-10 Finland
Heart failure, unspecified
3.7
41.6
146
436
I34.09
ICD-10 Finland
Mitral (valve) insufficiency
5.8
41.2
78
142
290
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.4
41.2
165
537
Q21.1
ICD-10 Finland
Atrial septal defect
+∞
40.8
39
*
Z45.0
ICD-10 Finland
Adjustment and management of cardiac devices
6.8
40.6
65
100
Q23.11
ICD-10 Finland
Bicuspid aortic valve
11.7
40.5
42
37
Q21.18
ICD-10 Finland
Other spedified atrial septal defect
211.9
40.1
41
*
C03DA01
ATC
spironolactone; oral
3.4
39.7
156
501
APK
HP
ASD closure
+∞
38.7
37
*
I49.5
ICD-10 Finland
Sick sinus syndrome
6.5
37.5
63
102
62
HP
Catheterization and pressure measurement of the right side of the heart
70.5
36.1
41
6
FFC50
NOMESCO Finland
Closure of ostium secundum type ASD using patch
367.6
36.1
36
*
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.4
36.0
328
1640
I48.9
ICD-10 Finland
Atrial fibrillation and atrial flutter, unspecified
4.9
34.6
79
170
Q21.20
ICD-10 Finland
Atrial septal defect of primum type
346.2
34.1
34
*
I50.0
ICD-10 Finland
Congestive heart failure
4.6
34.1
85
197
I48.2
ICD-10 Finland
Chronic atrial fibrillation
6.2
33.5
59
100
351
Kela drug reimbursment
Apixaban, dabigatran, edoxaban and rivaroxaban for the treatment of atrial fibrillation
3.3
33.4
142
477
XF640, ,
NOMESCO Finland
7.4
33.1
49
69
Z95.2
ICD-10 Finland
Presence of prosthetic heart valve
10.0
33.0
38
39
C07AA07
ATC
sotalol; systemic
6.2
32.1
56
94
74639
ICD-8 Finland
Congenital anomalies of heart, Defectus septi ventriculorum
73.9
32.0
36
5
ZXD10
NOMESCO Finland
Scheduled procedure
2.1
31.3
478
2919
I63.9
ICD-10 Finland
Cerebral infarction, unspecified
3.6
31.0
111
334
74663
ICD-8 Finland
Congenital anomalies of heart, Stenosis valvulae pulmonalis
320.5
30.9
31
*
AF1
HP
Surgery of congenital heart defect
164.0
30.8
32
*
XX3BT
NOMESCO Finland
Other labeling with X-ray guidance
8.0
30.7
42
54
Q25.0
ICD-10 Finland
Patent ductus arteriosus
7.6
29.3
42
57
TFC99
NOMESCO Finland
Catheterisation of heart with other procedure
9.4
29.1
35
38
ZXE10
NOMESCO Finland
More than one and less than three hours
2.1
28.7
427
2563
B01AF02
ATC
apixaban; oral
3.2
28.3
123
418
74646
ICD-8 Finland
Congenital anomalies of heart, Defectus septi atriorum, ostium primum
+∞
28.2
27
*
ZXE30
NOMESCO Finland
More than five and less than seven hours
3.6
27.4
94
275
Z03.5
ICD-10 Finland
Observation for other suspected cardiovascular diseases
2.9
27.2
141
529
I63.4
ICD-10 Finland
Cerebral infarction due to embolism of cerebral arteries
5.7
27.2
51
92
I34.1
ICD-10 Finland
Mitral (valve) prolapse
6.3
27.1
46
75
I34.00
ICD-10 Finland
Mitral (valve) incompetence NOS or of specified cause, except rheumatic
8.2
26.9
36
45
I48.0
ICD-10 Finland
Paroxysmal atrial fibrillation
3.6
26.7
91
265
ZXE20
NOMESCO Finland
More than three and less than five hours
2.5
26.3
182
791
I69.3
ICD-10 Finland
Sequelae of cerebral infarction
3.8
26.2
85
239
XF600
NOMESCO Finland
Bloodpressure measurement
2.8
24.7
134
515
FN1BC
NOMESCO Finland
Extensive angiography of hear and/or coronary arteries
3.9
24.1
72
191
I48.1
ICD-10 Finland
Persistent atrial fibrillation
5.2
23.6
49
97
FPE20
NOMESCO Finland
Implantation of transvenous cardiac pacemaker with atrial and ventricular electrodes
5.0
22.8
50
104
WX892
NOMESCO Finland
Monitored bed care
2.9
22.7
116
431
Z2221
NOMESCO Finland
Medical doctor
2.0
22.5
347
2074
TFB00
NOMESCO Finland
Cathetrisation of pulmonal artery
8.5
22.2
29
35
7456A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Endocardial cushion defects[DEFECTUS SEPTI ATRIORUM NUD]
+∞
21.9
21
*
Q21.21
ICD-10 Finland
Atrioventricular duct
44.1
21.4
26
6
XF622
NOMESCO Finland
Measurement of minute volume of heart
19.8
20.9
31
16
C01BD01
ATC
amiodarone; systemic
5.6
20.1
38
69
7454B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM SIMPLEX]
+∞
19.8
19
*
TFP34
NOMESCO Finland
Electrophysiological investigation
4.3
19.6
52
126
C01BC04
ATC
flecainide; systemic
4.2
17.7
47
114
FM1CG
NOMESCO Finland
Extensive examination of hear with high intensity magnet
14.8
17.6
29
20
WX882
NOMESCO Finland
High dependency care
2.7
17.6
98
380
I44.1
ICD-10 Finland
Atrioventricular block, second degree
6.6
17.5
28
43
AP2
HP
Catheterization of the right side of the heart
42.6
17.3
21
5
I44.2
ICD-10 Finland
Atrioventricular block, complete
5.3
17.2
35
68
ZXD05
NOMESCO Finland
Urgent procedure
1.8
17.1
331
2096
Q20.1
ICD-10 Finland
Double outlet right ventricle
31.9
17.0
22
7
Q20.3
ICD-10 Finland
Discordant ventriculoarterial connection
17.7
16.9
26
15
XF614
NOMESCO Finland
Measurement of pulmonary artery pressure
+∞
16.7
16
*
I50.1
ICD-10 Finland
Left ventricular failure
4.0
16.3
46
117
R06.0
ICD-10 Finland
Dyspnoea
1.9
16.2
262
1565
I47.1
ICD-10 Finland
Supraventricular tachycardia
3.0
15.9
70
239
4273A
ICD-9 Finland
Cardiac dysrhythmias, Atrial fibrillation and flutter
14.7
15.8
26
18
Z01.8
ICD-10 Finland
Other specified special examinations
1.9
15.8
250
1482
AP3
HP
Catheterization of the right and left side of the heart
60.7
15.8
18
*
WX402
NOMESCO Finland
General anaesthesia
1.8
15.7
275
1683
I48.4
ICD-10 Finland
Atypical atrial flutter
22.3
15.5
22
10
AN1
HP
Coronary angiography
2.7
15.4
85
328
B01AB05
ATC
enoxaparin; parenteral
1.8
15.4
273
1676
I49.3
ICD-10 Finland
Ventricular premature depolarization
2.8
15.4
79
294
Q21.0
ICD-10 Finland
Ventricular septal defect
19.4
14.2
21
11
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.2
14.2
136
674
I42.0
ICD-10 Finland
Dilated cardiomyopathy
5.0
14.0
30
61
R04.0
ICD-10 Finland
Epistaxis
2.6
13.9
81
322
Q23.10
ICD-10 Finland
Congenital insufficiency of aortic valve
20.3
13.8
20
10
F70.0
ICD-10 Finland
Mild mental retardation, With the statement of no, or minimal, impairment of behaviour
6.3
13.7
23
37
I49.1
ICD-10 Finland
Atrial premature depolarization
3.5
13.6
47
138
TFP44
NOMESCO Finland
Ablation treatment of typical atrial flutter
14.9
13.6
22
15
Q21.29
ICD-10 Finland
Atrioventricular septal defect UNS
+∞
13.5
13
*
Q87.14
ICD-10 Finland
Noonan's syndrome
34.4
13.5
17
5
FPE30
NOMESCO Finland
Replacement of transvenous cardiac pacemaker pulse generator
9.8
13.2
26
27
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
1.9
13.2
186
1058
Q90.9
ICD-10 Finland
Down syndrome, unspecified
40.4
13.2
16
*
FN1CD
NOMESCO Finland
Very extensive CT of coronary arteries
12.3
13.1
23
19
O99.4
ICD-10 Finland
Diseases of the circulatory system complicating pregnancy, childbirth and the puerperium
12.3
13.1
23
19
R4110
NOMESCO Finland
Physiotherapy
1.7
13.1
307
2030
FHB50
NOMESCO Finland
Transatrial closure of VSD using patch
16.9
13.0
20
12
Z95.8
ICD-10 Finland
Presence of other cardiac and vascular implants and grafts
28.6
13.0
17
6
FFC32
NOMESCO Finland
Percutaneous transluminal closure of sinus venosus type ASD
+∞
12.5
12
*
C07AB02
ATC
metoprolol; systemic
2.0
12.5
157
858
Q26.1
ICD-10 Finland
Persistent left superior vena cava
24.5
12.5
17
7
GA4YT
NOMESCO Finland
Puncture of pleura with ultrasound guidance
4.0
12.4
35
89
RS224, ,
NOMESCO Finland
4.9
12.4
27
56
K80
ICPC
Cardiac arrhythmia NOS
2.5
12.1
81
344
I27.2
ICD-10 Finland
Other secondary pulmonary hypertension
21.5
12.0
17
8
ZXE00
NOMESCO Finland
One hour or less
1.6
12.0
430
3150
Q21.12
ICD-10 Finland
Defective sinus venosus
47.0
11.9
14
*
I37.0
ICD-10 Finland
Pulmonary valve stenosis
47.0
11.9
14
*
Q22.5
ICD-10 Finland
Ebstein anomaly
47.0
11.9
14
*
Z98.8
ICD-10 Finland
Other specified postsurgical states
4.5
11.6
28
63
5255
FHL
Deep hypothermia (<20 °) with cardiopulmonary resuscitation
+∞
11.5
11
*
81
HP
Angiography of the heart and coronary arteries
3.3
11.3
43
135
FP4B5
NOMESCO Finland
ECG, prolonged recording (24 h)
5.2
11.2
23
45
Z3231
NOMESCO Finland
Registered nurse
1.6
11.2
337
2358
TPH04
NOMESCO Finland
Cathetrisation of vein
1.7
11.2
215
1339
Q21.30
ICD-10 Finland
Tetralogy of Fallot
13.0
10.6
18
14
74699
ICD-8 Finland
Congenital anomalies of heart, Unspecified anomalies of heart
60.4
10.6
12
*
FGC10
NOMESCO Finland
Annuloplasty of tricuspid valve using prosthetic ring
60.4
10.6
12
*
WZB00
NOMESCO Finland
Telephone prescription or other care instructions
1.6
10.6
320
2238
B01AE07
ATC
dabigatran etexilate; oral
3.6
10.5
34
96
7454A
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Ventricular septal defect[DEFECTUS SEPTI VENTRICULORUM NUD]
+∞
10.4
10
*
B01AC04
ATC
clopidogrel; oral
2.0
10.4
113
586
I71.2
ICD-10 Finland
Thoracic aortic aneurysm, without mention of rupture
4.4
10.2
25
57
Q90.0
ICD-10 Finland
Trisomy 21, meiotic nondisjunction
23.5
10.2
14
6
FM1CD
NOMESCO Finland
Very extensive CT of heart
23.5
10.2
14
6
C01BD07
ATC
dronedarone; oral
13.2
10.2
17
13
D50.0
ICD-10 Finland
Iron deficiency anaemia secondary to blood loss (chronic)
3.5
10.1
35
103
Z31.5
ICD-10 Finland
Genetic counselling
2.2
10.1
90
433
342
Kela drug reimbursment
Dronedarone
11.4
10.0
18
16
TFP35
NOMESCO Finland
Electroanatomical mapping
4.7
10.0
23
50
I47.2
ICD-10 Finland
Ventricular tachycardia
4.6
9.8
23
51
WX704
NOMESCO Finland
Intubation
2.2
9.6
85
407
51
HP
Other heart surgery
100.5
9.4
10
*
APJ
HP
PFO closure
100.5
9.4
10
*
K84
ICPC
Heart disease other
3.9
9.4
27
70
5207
FHL
VSD closure
+∞
9.4
9
*
7460C
ICD-9 Finland
Other congenital anomalies of heart, Anomalies of pulmonary valve[VITIUM VALVULAE PULMONALIS CONGENITA CUM STENOSIS]
+∞
9.4
9
*
I51.0
ICD-10 Finland
Cardiac septal defect, acquired
+∞
9.4
9
*
I49.8
ICD-10 Finland
Other specified cardiac arrhythmias
3.3
9.3
35
109
XXA00
NOMESCO Finland
Clinical examination requiring general anaesthesia
4.9
9.3
20
41
I97.0
ICD-10 Finland
Postcardiotomy syndrome
15.7
9.0
14
9
FKB10
NOMESCO Finland
Annuloplasty of mitral valve for insufficiency using ring
10.1
9.0
17
17
TFP45
NOMESCO Finland
Ablation treatment of non-typical atrial flutter
24.1
8.9
12
5
Q26.3
ICD-10 Finland
Partial anomalous pulmonary venous connection
24.1
8.9
12
5
I27.9
ICD-10 Finland
Pulmonary heart disease, unspecified
24.1
8.9
12
5
C09AA05
ATC
ramipril; oral
1.7
8.9
169
1045
R07.4
ICD-10 Finland
Chest pain, unspecified
1.6
8.9
233
1567
K90
ICPC
Stroke/cerebrovascular accident
3.8
8.8
26
69
I48.3
ICD-10 Finland
Typical atrial flutter
9.5
8.8
17
18
FFC42
NOMESCO Finland
Percutaneous closure of patent foramen ovale
50.2
8.7
10
*
GA1AE
NOMESCO Finland
Ultrasound examination of thorax
3.6
8.7
28
79
TFP30
NOMESCO Finland
Cathetric examination for cardiac arrythmia
7.7
8.6
19
25
I44.0
ICD-10 Finland
Atrioventricular block, first degree
7.7
8.6
19
25
AA1AD
NOMESCO Finland
CT of head and brain
1.6
8.6
207
1361
R01.1
ICD-10 Finland
Cardiac murmur, unspecified
2.8
8.5
43
159
GD1AD
NOMESCO Finland
Thorax CT examination
2.5
8.5
51
206
I37.1
ICD-10 Finland
Pulmonary valve insufficiency
27.6
8.5
11
*
602
Kela drug reimbursment
Children's severe malnutrition
2.9
8.4
38
132
B01AF01
ATC
rivaroxaban; oral
2.0
8.4
95
499
Q90
ICD-10 Finland
Down syndrome
90.4
8.4
9
*
42700
ICD-8 Finland
Symptomatic heart disease, Congestive heart failure
90.4
8.4
9
*
74689
ICD-8 Finland
Congenital anomalies of heart, Aliae definitae
90.4
8.4
9
*
C07AB03
ATC
atenolol; systemic
2.6
8.3
46
179
289
Kela drug reimbursment
Combination product containing sacubitril and valsartan
9.5
8.3
16
17
J69.0
ICD-10 Finland
Pneumonitis due to food and vomit
4.8
8.1
18
38
PD5BD
NOMESCO Finland
Extensive CT of aorta
6.3
8.0
20
32
I35.0
ICD-10 Finland
Aortic (valve) stenosis
2.7
8.0
42
159
GD1QA
NOMESCO Finland
Supine thorax X-ray examination
1.8
8.0
121
701
R62.0
ICD-10 Finland
Delayed milestone
2.5
7.9
48
195
R50.9
ICD-10 Finland
Fever, unspecified
1.6
7.9
198
1315
K77
ICPC
Heart failure
4.5
7.9
19
43
GAA10
NOMESCO Finland
Intercostal insertion of pleural drainage tube
3.8
7.8
23
61
Q23.0
ICD-10 Finland
Congenital stenosis of aortic valve
9.5
7.8
15
16
FPD96
NOMESCO Finland
Other operation for atrial fibrillation
45.1
7.7
9
*
74719
ICD-8 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta
45.1
7.7
9
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
1.6
7.7
209
1414
WZC30
NOMESCO Finland
Teaching
1.7
7.6
139
849
J01CA04
ATC
amoxicillin; systemic
1.6
7.6
930
8456
I27.0
ICD-10 Finland
Primary pulmonary hypertension
25.1
7.6
10
*
FEB10
NOMESCO Finland
Decompression and drainage of pericardium
8.9
7.5
15
17
J96.1
ICD-10 Finland
Chronic respiratory failure
4.1
7.5
20
49
SPAT1097
SPAT
Recording of ECG
1.8
7.5
111
638
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
2.1
7.4
72
358
Q24.8
ICD-10 Finland
Other specified congenital malformations of heart
80.3
7.4
8
*
K99
ICPC
Cardiovascular disease other
3.9
7.4
21
54
GAE10
NOMESCO Finland
Closure of previous incision of chest wall
6.0
7.4
19
32
SPAT1253
SPAT
Initiation, adjustment, discontinuation or repetition of medication
1.5
7.3
305
2260
Q21.2
ICD-10 Finland
Atrioventricular septal defect
+∞
7.3
7
*
3810A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Acute nonsuppurative otitis media
10.9
7.3
13
12
I34.9
ICD-10 Finland
Nonrheumatic mitral valve disorder, unspecified
15.8
7.2
11
7
AA5BD
NOMESCO Finland
CT of cerebral ischaemia
3.7
7.2
22
60
Q24.6
ICD-10 Finland
Congenital heart block
30.1
7.1
9
*
AR5
HP
Catheter ablation of arrhythmia, target: atrial flutter
30.1
7.1
9
*
Q24.4
ICD-10 Finland
Congenital subaortic stenosis
20.1
7.1
10
5
C09DX04
ATC
valsartan and sacubitril; oral
8.0
7.1
15
19
I25.1
ICD-10 Finland
Atherosclerotic heart disease
1.7
7.1
122
733
381
Kela drug reimbursment
Combination product containing sacubitril and valsartan
8.8
7.0
14
16
FXA10
NOMESCO Finland
Total cardiopulmonary bypass in deep hypothermia at concurrent surgical procedure
8.8
7.0
14
16
I50
ICD-10 Finland
Heart failure
3.4
7.0
24
71
F83
ICD-10 Finland
Mixed specific developmental disorders
2.6
6.9
39
153
3812A
ICD-9 Finland
Nonsuppurative otitis media and Eustachian tube disorders, Chronic mucoid otitis media
3.7
6.9
21
57
PH2AE
NOMESCO Finland
Ultrasound examination of lower leg veins
1.9
6.8
89
491
250, ,
Kela drug reimbursment
6.7
6.8
16
24
T81.0
ICD-10 Finland
Haemorrhage and haematoma complicating a procedure, not elsewhere classified
2.2
6.8
55
255
I34.0
ICD-10 Finland
Mitral (valve) insufficiency
4.1
6.8
18
44
K83
ICPC
Heart valve disease NOS
11.0
6.8
12
11
H53.0
ICD-10 Finland
Amblyopia ex anopsia
3.1
6.8
28
93
7471A
ICD-9 Finland
Other congenital anomalies of circulatory system, Coarctation of aorta[COARCTATIO AORTAE]
40.2
6.7
8
*
GE1BE
NOMESCO Finland
Mediastinal ultrasound examinaiton through oesophagus
16.7
6.7
10
6
Q25.78
ICD-10 Finland
Other congenital malformations of pulmonary artery
16.7
6.7
10
6
PA6DE
NOMESCO Finland
Neck artery ultrasound examination with Doppler method
2.6
6.7
37
144
3820A
ICD-9 Finland
Suppurative and unspecified otitis media, Acute suppurative otitis media
3.9
6.7
19
49
TFC20
NOMESCO Finland
Catheterisation of both sides of heart
22.6
6.7
9
*
R42
ICD-10 Finland
Dizziness and giddiness
1.6
6.7
178
1197
PA7AD
NOMESCO Finland
CT angiography of head and neck vasculature
2.9
6.6
30
105
EB1HA
NOMESCO Finland
Panorama tomography of teeth and jaws or similar X-ray examination
1.4
6.6
445
3584
J90
ICD-10 Finland
Pleural effusion, not elsewhere classified
3.1
6.6
27
89
G43.1
ICD-10 Finland
Migraine with aura [classical migraine]
1.8
6.6
92
519
FJF20
NOMESCO Finland
Replacement of pulmonary valve using homograft
12.3
6.6
11
9
G45.9
ICD-10 Finland
Transient cerebral ischaemic attack, unspecified
2.2
6.5
56
266
A08.4
ICD-10 Finland
Viral intestinal infection, unspecified
2.0
6.5
69
355
AS4
HP
Physiological pacemaker insertion DDD (R)
6.9
6.5
15
22
I63.3
ICD-10 Finland
Cerebral infarction due to thrombosis of cerebral arteries
3.0
6.5
27
90
XG412
NOMESCO Finland
Flow-volume spirometry with bronchospasmolysis
2.0
6.5
65
328
ZXE40
NOMESCO Finland
More than seven and less than nine hours
2.7
6.5
34
129
FGE10
NOMESCO Finland
Replacement of tricuspid valve using biological prosthesis
70.0
6.4
7
*
7451B
ICD-9 Finland
Bulbus cordis anomalies and anomalies of cardiac septal closure, Transposition of great vessels[DOUBLE OUTLET RIGHT VENTRICLE]
70.0
6.4
7
*
AH3
HP
Treatment of arrhythmias, eg atrial fibrillation, in conjunction with other cardiac surgery
70.0
6.4
7
*
Q90.1
ICD-10 Finland
Trisomy 21, mosaicism (mitotic nondisjunction)
70.0
6.4
7
*
74690
ICD-8 Finland
Congenital anomalies of heart, Maleformatio cordis suspecta
70.0
6.4
7
*
Q20.5
ICD-10 Finland
Discordant atrioventricular connection
70.0
6.4
7
*
Q24.9
ICD-10 Finland
Congenital malformation of heart, unspecified
70.0
6.4
7
*
4122
FHL
Tympanostomy (tympanic tube)
3.4
6.4
22
65
Q25.6
ICD-10 Finland
Stenosis of pulmonary artery
14.3
6.4
10
7
P07.3
ICD-10 Finland
Other preterm infants
2.8
6.3
30
108
TPX22
NOMESCO Finland
Intravenous arterial thrombolysis
11.1
6.3
11
10
FP1B5
NOMESCO Finland
Resting ECG, 12 leads
3.0
6.3
27
92
APX
HP
Other cardiac catheter operation
+∞
6.2
6
*
7463A
ICD-9 Finland
Other congenital anomalies of heart, Congenital stenosis of aortic valve[STENOSIS VALVULAE AORTAE CONGENITA]
+∞
6.2
6
*
FFC96
NOMESCO Finland
Other closure of isolated atrial septal defect
26.7
6.2
8
*
74
HP
Initial installation of the atrial pacemaker
26.7
6.2
8
*
C03EB01
ATC
furosemide and potassium-sparing agents; systemic
2.9
6.1
28
99
Q25.41
ICD-10 Finland
Persistent right-sided aortic arch
12.6
6.1
10
8
M41.1
ICD-10 Finland
Juvenile idiopathic scoliosis
3.8
6.1
18
48
JN3AD
NOMESCO Finland
Abdominal CT examination
1.8
6.1
87
496
FMD00
NOMESCO Finland
Replacement of aortic valve using mechanical prosthesis
8.6
6.0
12
14
Q20.48
ICD-10 Finland
Single ventricle
10.1
6.0
11
11
XX9BW
NOMESCO Finland
Submitting image material and/or investigation material to authority or other institution
3.6
6.0
19
53
UGC02
NOMESCO Finland
Rigid bronchoscopy
5.2
6.0
17
33

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
484
1741
4.15
115.03
5.4
3.6
1309.43
1120.87
ng/l
0.45
446
1455
632
3146
3.34
84.39
25.8
10.5
1.49
1.17
inr
8.22
166
942
209
519
4.72
78.70
3.2
4.1
198.23
200.90
ng/l
0.03
193
473
342
1339
3.24
65.43
3.2
4.0
31.03
30.17
s
1.51
332
1308
319
1377
2.84
49.49
3.8
3.6
1388.87
511.31
ng/l
1.35
257
940
386
2055
2.34
36.87
2.4
2.6
—
—
—
0
0
409
2241
2.30
36.43
5.8
5.8
80.80
91.51
%
12.42
402
2190
440
2620
2.12
30.66
2.6
2.7
—
—
—
0
0
264
1324
2.30
27.89
6.2
7.4
0.83
0.81
mmol/l
1.00
251
1258
572
3883
1.97
26.53
2.9
2.8
—
—
—
0
0
135
509
2.87
25.79
1.8
2.4
15.29
6.53
ug/l
2.56
116
447
698
5232
1.90
22.36
4.6
3.3
—
—
—
0
0
122
479
2.73
21.49
3.8
5.3
21.99
22.48
s
0.59
104
445
28
34
8.39
21.36
3.3
8.3
—
—
—
0
0
313
1888
1.91
19.24
5.3
3.5
—
—
—
0
0
100
382
2.77
18.52
20.8
13.6
—
—
—
0
0
660
5055
1.75
17.65
8.1
6.0
6.23
6.40
mmol/l
1.59
627
4704
157
757
2.24
17.63
15.2
9.8
1.14
0.77
mmol/l
0.56
139
604
378
2514
1.76
16.43
4.4
3.2
50.77
51.33
ng/l
0.01
257
1531
996
8880
2.20
13.94
21.4
14.4
139.54
139.56
mmol/l
0.05
991
8653
200
1146
1.90
13.89
14.9
10.7
—
—
—
0
0
70
262
2.77
13.47
2.0
2.1
1.21
1.38
g/l
0.85
56
231
23
18
12.98
13.41
2.7
2.9
—
—
—
0
0
995
8894
2.16
13.39
21.6
14.4
3.98
3.95
mmol/l
2.40
989
8641
322
2156
1.69
13.10
2.6
2.3
249.51
247.80
u/l
0.01
301
2052
59
206
2.96
12.89
5.1
12.5
—
—
—
0
0
190
1115
1.84
12.14
3.4
2.8
20.46
22.62
%
1.60
174
1005
520
3975
1.57
12.09
12.8
9.4
1.21
1.22
mmol/l
4.93
487
3697
229
1431
1.75
11.83
8.4
9.1
1.24
1.21
mmol/l
0.62
220
1362
173
994
1.87
11.80
10.2
9.3
—
—
—
0
0
48
159
3.10
11.50
1.3
1.2
3.53
5.93
u/ml
0.73
19
70
197
1205
1.77
10.89
3.3
2.7
2.48
2.44
g/l
0.43
186
1132
194
1186
1.76
10.74
10.1
9.0
7.40
7.41
ph
—
10
66
210
1318
1.73
10.59
3.3
2.7
12.59
13.65
umol/l
1.33
199
1246
24
54
4.50
10.00
1.7
1.4
—
—
—
0
0
31
85
3.71
9.97
3.2
3.1
0.82
0.86
nmol/l
0.12
25
66
518
4077
1.50
9.82
8.2
6.9
16.85
14.88
umol/l
0.79
483
3835
22
47
4.74
9.74
1.9
1.3
21434.67
58156.93
e6/l
0.67
15
29
277
1915
1.59
9.47
4.6
4.4
—
—
—
0
0
200
1278
1.68
9.36
6.4
8.7
1.59
1.42
mmol/l
0.29
170
1034
267
1849
1.58
9.00
3.0
2.7
1.38
1.36
mg/l
0.02
189
1396
539
4328
1.47
8.95
11.3
9.4
1.21
1.22
mmol/l
3.28
472
3816
431
3334
1.47
8.55
5.8
6.0
36.09
36.53
g/l
0.85
404
3144
136
804
1.78
8.36
18.4
10.5
1.27
1.38
mmol/l
0.50
136
785
36
122
3.01
8.35
7.3
7.5
11.46
11.12
mg/l
0.12
30
116
989
9103
1.79
8.11
17.5
12.5
23.91
21.84
mg/l
1.23
814
6803
164
1046
1.66
7.65
3.4
4.7
1.92
1.60
%
2.00
154
974
1011
9395
1.86
7.63
16.6
11.0
—
—
—
0
0
361
2747
1.46
7.59
1.4
1.6
—
—
—
0
0
70
346
2.08
7.35
1.2
1.7
—
12.66
—
0
10
126
759
1.74
7.25
3.0
3.7
77.17
67.60
e9/l
1.38
92
524
32
111
2.93
7.16
5.9
19.2
11.58
11.29
%
0.27
32
111
18
44
4.13
6.79
1.9
1.3
—
—
—
0
0
19
49
3.91
6.69
2.1
1.7
—
—
—
0
0
40
162
2.52
6.69
7.3
5.3
1.71
2.27
mmol/l
0.87
26
100
167
1120
1.57
6.31
2.5
2.0
—
—
—
0
0
548
4625
1.36
5.87
7.2
8.2
—
—
—
0
0
69
374
1.89
5.64
5.0
6.2
—
—
—
0
0
48
231
2.12
5.46
1.2
1.3
—
7.74
—
0
5
291
2240
1.40
5.44
2.9
2.7
3.02
2.84
mg/l
0.71
258
1966
37
162
2.32
5.28
3.0
3.0
17.75
16.88
%
0.76
22
97
571
4903
1.33
5.21
6.8
7.6
0.59
0.57
e9/l
0.98
495
4182
585
5055
1.33
5.04
6.7
7.6
1.93
2.13
e9/l
2.70
517
4427
15
32
4.72
4.98
1.1
1.3
—
—
—
0
0
569
4905
1.32
4.95
6.8
7.6
0.04
0.04
e9/l
1.10
494
4180
585
5066
1.32
4.91
7.2
8.2
0.18
0.20
e9/l
1.63
516
4402
38
182
2.12
4.42
5.6
4.2
—
—
—
0
0
155
1108
1.46
4.31
1.8
1.7
1161.55
1163.91
nmol/l
0.01
112
835
22
83
2.67
4.31
1.8
2.4
—
—
—
0
0
86
544
1.62
4.17
1.8
3.1
65.85
66.31
g/l
0.18
78
508
351
2887
1.31
4.08
4.0
4.0
34.48
32.36
u/l
0.18
328
2764
149
1074
1.44
3.97
5.2
5.3
9.96
7.36
umol/l
0.63
134
901
35
170
2.09
3.96
5.0
5.4
—
—
—
0
0
687
6183
1.28
3.87
8.0
6.8
92.72
92.79
u/l
0.01
652
5818
21
82
2.58
3.87
2.1
3.8
—
—
—
0
0
22
88
2.52
3.87
2.1
2.3
32.45
32.16
pg
0.11
22
88
521
4548
1.27
3.71
7.2
7.8
0.62
0.66
%
1.22
497
4317
492
4280
1.26
3.56
3.8
3.0
99.06
89.69
ug/l
0.47
458
4016
536
4712
1.26
3.54
7.4
8.0
8.63
8.35
%
1.34
513
4483
702
6370
1.27
3.53
4.6
4.2
10.56
10.21
mm/h
0.34
671
5927
294
2405
1.30
3.48
3.0
2.6
63.73
57.42
u/l
0.84
273
2228
15
52
2.90
3.45
1.2
1.1
—
—
—
0
0
274
2228
1.30
3.39
4.5
3.9
7.40
7.40
ph
0.19
63
407
551
4879
1.25
3.35
7.2
7.7
28.84
31.89
%
7.65
528
4659
531
4684
1.25
3.33
7.2
7.7
2.84
3.01
%
0.93
507
4451
615
5545
1.24
3.06
9.5
10.2
3.93
3.81
e9/l
0.71
543
4759
512
4530
1.24
3.03
9.9
10.4
0.00
0.00
e9/l
0.06
406
3600
540
4816
1.23
2.93
6.9
7.5
55.99
53.13
%
5.94
517
4592
33
177
1.88
2.90
2.7
2.6
—
—
—
0
0
63
933
0.65
2.77
1.3
1.3
—
—
—
0
0
82
568
1.47
2.73
3.3
3.2
4.62
4.77
pmol/l
0.49
74
513
7
15
4.67
2.59
1.1
1.1
—
—
—
0
0
755
7019
1.23
2.56
4.6
3.9
14.82
14.57
pmol/l
1.93
697
6472
8
20
4.01
2.56
1.1
1.1
—
—
—
0
0
8
20
4.01
2.56
1.1
12.7
—
—
—
0
0
21
403
0.51
2.50
1.0
1.2
3.56
3.23
u/ml
0.04
14
283
17
75
2.28
2.49
43.7
45.2
6.64
6.50
ug/l
0.12
17
68
197
1595
1.28
2.48
1.7
1.4
18.98
21.44
nmol/l
1.59
176
1375
9
27
3.34
2.38
1.2
1.2
—
—
—
0
0
22
408
0.53
2.36
1.0
1.2
1.53
1.11
u/ml
0.12
14
276
22
111
1.99
2.34
2.0
1.7
—
—
—
0
0
308
2644
1.22
2.31
2.7
3.2
2.36
2.37
mmol/l
0.65
266
2389
156
1238
1.30
2.30
1.5
1.4
590.00
498.71
titre
0.28
28
248
23
417
0.54
2.30
1.0
1.2
2.73
5.09
u/ml
0.54
17
301
126
972
1.33
2.28
1.7
1.5
—
—
—
0
0
10
35
2.86
2.20
1.5
1.9
—
—
—
0
0
139
1101
1.30
2.09
2.3
1.6
—
—
—
0
0
27
453
0.58
2.07
1.1
1.2
7.41
3.33
u/ml
0.37
19
316
189
1558
1.25
2.06
3.0
3.0
1.17
0.97
e6/l
0.29
113
862
25
139
1.81
2.04
1.9
1.5
—
—
—
0
0
27
154
1.77
2.03
1.4
1.4
24.97
20.11
u/l
0.28
21
131
221
1862
1.23
1.97
3.4
2.8
5.56
6.77
e6/l
0.65
206
1649
68
489
1.41
1.93
1.3
1.2
—
—
—
0
0
1056
10308
1.48
1.92
25.9
18.4
4.48
4.53
e12/l
2.38
1037
9942
219
1849
1.22
1.92
3.7
3.1
3600.06
5294.03
umol/l
0.21
197
1651
22
120
1.84
1.91
1.1
1.5
—
—
—
0
0
1056
10309
1.48
1.91
25.9
18.4
6.78
6.78
e9/l
0.03
1038
9942
369
3274
1.18
1.90
4.8
4.2
33.28
93.92
e6/l
3.01
266
2225
94
715
1.34
1.90
6.2
6.0
80.16
65.39
ng/l
1.59
79
670
1056
10312
1.47
1.87
26.8
18.6
132.62
134.18
g/l
2.84
1051
10187
1055
10301
1.46
1.86
26.0
18.5
250.01
261.79
e9/l
6.87
1039
9965
347
3072
1.18
1.82
2.0
2.0
—
—
—
0
0
11
233
0.47
1.80
1.0
1.1
0.02
0.49
u/ml
—
5
117
646
6018
1.17
1.78
4.8
4.2
—
—
—
0
0
106
829
1.30
1.78
1.2
1.4
193.92
275.85
u/ml
0.70
99
771
857
8173
1.20
1.77
5.3
4.5
1.96
2.03
mu/l
0.21
806
7619
1054
10297
1.44
1.77
27.5
18.8
39.44
39.91
%
1.85
1013
9785
77
576
1.36
1.75
4.7
4.5
1.23
1.23
mmol/l
0.07
70
501
8
30
2.67
1.72
2.3
1.5
69.35
87.33
nmol/24h
—
8
30
37
242
1.54
1.70
2.2
1.9
3.02
4.69
iu/l
0.95
16
89
83
632
1.33
1.69
5.3
4.2
—
—
—
0
0
17
90
1.90
1.64
1.5
1.3
—
—
—
0
0
73
548
1.35
1.63
1.6
1.5
—
—
—
0
0
5
14
3.57
1.61
2.6
2.1
—
—
—
0
0
281
2469
1.18
1.60
3.2
2.8
—
—
—
0
0
288
2536
1.18
1.60
4.0
3.5
0.42
0.35
e6/l
0.32
232
1886
80
612
1.33
1.59
3.8
4.6
0.77
0.55
%
0.51
31
209
15
271
0.55
1.56
1.1
1.1
1.95
7.85
u/ml
—
9
166
39
264
1.49
1.55
2.9
4.0
29.72
36.04
umol/l
1.87
39
244
876
8402
1.19
1.54
21.0
16.0
14.52
14.25
%
0.83
866
8281
24
145
1.66
1.53
7.4
4.9
—
—
—
0
0
81
626
1.31
1.51
4.6
5.0
0.21
0.12
%
0.33
31
204
69
895
0.75
1.50
1.7
1.8
—
—
—
0
0
78
602
1.31
1.47
4.7
5.1
0.12
0.07
%
0.24
26
177
85
664
1.30
1.47
4.6
4.9
1.23
0.94
%
0.38
37
242
211
1822
1.19
1.47
4.0
3.0
572.63
556.90
mosm/kgh2o
0.43
197
1565
318
2845
1.16
1.43
2.2
1.8
96.51
96.86
pmol/l
0.05
193
1460
5
16
3.12
1.43
1.4
1.3
—
—
—
0
0
5
16
3.12
1.43
6.4
14.4
—
—
—
0
0
5
16
3.12
1.43
1.6
1.7
—
—
—
0
0
610
5713
1.14
1.42
4.8
4.1
11.20
2704.81
e6/l
—
10
75
53
388
1.38
1.41
1.4
2.3
—
—
—
0
0
14
249
0.55
1.40
1.1
1.1
6.19
9.42
u/ml
—
7
136
15
81
1.86
1.39
4.4
2.5
—
—
—
0
0
14
74
1.90
1.38
1.6
1.7
—
—
—
0
0
41
289
1.43
1.36
1.2
1.2
—
—
—
0
0
5
17
2.94
1.35
1.6
1.1
—
—
—
0
0
308
2760
1.16
1.35
4.2
3.6
50.97
67.91
e6/l
0.23
252
2085
10
47
2.13
1.33
5.6
2.6
—
—
—
0
0
112
919
1.24
1.32
1.1
1.2
—
—
—
0
0
128
1069
1.22
1.28
1.3
1.3
—
—
—
0
0
177
1525
1.19
1.27
3.3
3.3
3.66
2.56
e6/l
0.63
103
839
299
2694
1.15
1.21
7.5
8.2
—
—
—
0
0
16
94
1.71
1.16
1.1
1.2
—
—
—
0
0
279
2511
1.14
1.15
4.0
3.4
—
—
—
0
0
164
1418
1.18
1.14
1.5
1.6
454.02
40565690.23
pmol/l
1.93
141
1203
41
300
1.38
1.14
1.4
1.3
—
—
—
0
0
8
40
2.00
1.11
1.4
1.3
—
—
—
0
0
8
40
2.00
1.11
1.4
1.3
—
—
—
0
0
8
40
2.00
1.11
1.4
1.3
—
—
—
0
0
74
595
1.26
1.07
2.4
2.5
5.52
6.58
e9/l
0.24
58
532
34
244
1.40
1.07
5.0
4.3
10.44
12.07
umol/l
0.17
26
201
75
607
1.25
1.04
2.6
4.1
5.67
26.98
ug/l
0.91
59
487
10
53
1.89
1.00
1.1
1.1
302.88
233.17
iu/ml
—
10
53
788
7586
1.12
0.98
4.3
3.8
5.72
5.76
mmol/l
0.48
732
6985
34
249
1.37
0.97
2.0
3.2
50.23
879.58
u/ml
0.85
29
214
25
173
1.45
0.96
6.0
4.0
—
—
—
0
0
15
92
1.63
0.96
4.4
4.1
—
—
—
0
0
0
32
0.00
0.95
0.0
1.2
—
—
—
0
0
22
151
1.46
0.89
2.0
1.7
21316.06
16959.10
e6/l
0.20
16
115
5
105
0.47
0.88
1.0
3.9
24.30
22.77
ug/l
—
5
105
36
271
1.33
0.88
2.8
3.1
—
—
—
0
0
28
203
1.38
0.86
1.5
1.4
82.16
162.60
pmol/l
0.70
28
197
26
186
1.40
0.86
4.2
4.2
60.12
54.28
%
1.01
26
186
69
570
1.22
0.83
3.3
3.6
—
—
—
0
0
6
115
0.52
0.82
1.5
1.4
—
—
—
0
0
22
154
1.43
0.82
1.1
1.1
—
—
—
0
0
6
32
1.87
0.81
2.0
1.2
—
—
—
0
0
34
258
1.32
0.80
4.5
5.5
—
—
—
0
0
110
1256
0.86
0.80
1.5
1.7
—
—
—
0
0
0
24
0.00
0.79
0.0
4.2
—
—
—
0
0
0
24
0.00
0.79
0.0
2.1
—
—
—
0
0
0
26
0.00
0.78
0.0
2.0
—
—
—
0
0
728
7022
1.10
0.76
5.2
4.9
38.23
38.76
mmol/mol
0.85
689
6587
587
5614
1.09
0.73
3.9
3.6
50.65
41.44
u/l
1.72
558
5318
9
55
1.64
0.73
2.0
2.4
—
—
—
0
0
7
39
1.79
0.72
1.1
1.5
—
—
—
0
0
9
56
1.61
0.72
1.1
1.2
—
—
—
0
0
87
747
1.17
0.71
1.2
1.2
149.47
143.34
iu/ml
0.04
31
286
10
60
1.67
0.71
3.7
2.9
—
—
—
0
0
46
372
1.24
0.69
2.6
2.5
—
—
—
0
0
949
9293
1.13
0.68
11.4
9.8
25.64
26.15
u/l
0.27
927
9008
7
42
1.66
0.68
2.6
2.5
51328.57
38388.21
ug/l
—
7
42
11
69
1.59
0.67
1.7
1.4
1.52
1.38
promille
0.15
11
56
10
62
1.61
0.64
1.2
1.2
—
—
—
0
0
8
127
0.63
0.64
1.5
1.6
—
—
—
0
0
5
29
1.72
0.63
1.0
1.1
197.80
175.78
mmol/24h
—
5
29
5
29
1.72
0.63
3.0
2.6
—
—
—
0
0
113
1002
1.14
0.62
3.4
2.6
341.05
349.63
nmol/l
0.14
104
944
50
595
0.83
0.62
1.8
1.7
—
—
—
0
0
215
2313
0.91
0.62
4.2
3.1
—
—
—
0
0
5
30
1.66
0.61
1.2
1.3
—
—
—
0
0
30
377
0.79
0.61
1.5
1.3
198.76
233.49
miu/ml
0.28
16
181
10
63
1.59
0.61
1.4
1.1
—
—
—
0
0
31
244
1.27
0.60
15.0
7.9
—
—
—
0
0
45
371
1.22
0.59
2.1
1.9
—
—
—
0
0
0
23
0.00
0.58
0.0
1.3
—
—
—
0
0
19
140
1.36
0.57
1.7
1.5
—
—
—
0
0
14
195
0.71
0.57
1.0
1.5
1.83
4.11
u/ml
—
9
130
15
106
1.42
0.57
1.1
1.8
—
—
—
0
0
6
36
1.66
0.56
1.3
1.3
—
—
—
0
0
18
132
1.36
0.56
1.1
1.0
1.49
1.43
g/l
0.26
18
122
8
55
1.45
0.56
1.0
1.2
—
—
—
0
0
8
55
1.45
0.56
1.3
1.4
78.63
71.91
umol/l
—
8
55
14
99
1.41
0.53
1.6
1.5
—
—
—
0
0
14
191
0.73
0.52
1.1
1.5
10.48
12.15
u/ml
—
6
122
6
40
1.50
0.51
1.0
1.0
—
—
—
0
0
44
369
1.20
0.51
4.0
3.2
—
—
—
0
0
32
260
1.23
0.50
1.4
1.4
298.69
323.77
ug/g
0.30
16
148
154
1414
1.10
0.49
1.3
1.3
14.84
29.85
iu/ml
5.17
44
429
230
2152
1.08
0.48
3.4
3.4
—
—
—
0
0
19
244
0.77
0.48
4.7
2.0
0.84
0.70
nmol/l
0.27
13
207
7
47
1.49
0.47
5.0
4.0
83.03
148.58
ug/l
—
7
47
15
111
1.35
0.46
4.4
3.7
—
—
—
0
0
23
182
1.26
0.45
3.7
3.7
4.97
3.90
e9/l
0.99
23
182
13
94
1.38
0.45
1.5
4.2
—
—
—
0
0
33
273
1.21
0.45
5.7
4.2
25.70
22.14
nmol/l
0.57
33
268
11
152
0.72
0.45
1.0
1.2
1.18
2.73
u/ml
—
5
91
30
247
1.22
0.43
1.8
1.8
—
—
—
0
0
792
7746
1.07
0.43
4.3
4.0
4.46
4.68
mmol/l
8.03
753
7289
136
1252
1.09
0.42
2.5
2.7
2.41
2.44
mmol/l
1.88
110
1085
14
104
1.35
0.42
1.3
2.1
—
—
—
0
0
204
1912
1.08
0.42
4.1
3.8
8.01
17.45
mg/mmol
0.50
137
1227
15
113
1.33
0.42
1.3
1.3
—
—
—
0
0
0
15
0.00
0.41
0.0
11.6
—
96.13
—
0
15
5
33
1.51
0.41
1.4
1.6
—
—
—
0
0
5
33
1.51
0.41
1.0
1.1
4.57
5.48
mg/g
—
5
33
5
34
1.47
0.40
3.4
2.3
536.00
516.88
min
—
5
24
91
825
1.11
0.39
1.7
1.4
—
—
—
0
0
161
1714
0.93
0.39
1.7
1.7
—
—
—
0
0
7
105
0.66
0.39
1.1
1.3
6.52
3.15
u/ml
—
7
100
195
1832
1.07
0.38
3.5
3.3
329.50
235.83
mg/l
0.12
134
1210
45
513
0.87
0.38
2.6
2.5
—
—
—
0
0
275
2615
1.06
0.38
1.5
1.6
1.93
1.97
g/l
0.15
169
1447
74
667
1.11
0.36
1.4
1.5
—
—
—
0
0
17
211
0.80
0.35
1.0
1.0
-2.95
-2.01
mmol/l
—
6
50
17
211
0.80
0.35
1.0
1.0
—
—
—
0
0
35
403
0.86
0.34
1.1
1.1
—
—
—
0
0
15
188
0.79
0.34
1.6
1.3
—
—
—
0
0
49
549
0.88
0.33
1.8
1.9
—
—
—
0
0
12
91
1.32
0.33
1.1
1.1
—
—
—
0
0
6
87
0.69
0.33
1.2
1.0
—
—
—
0
0
14
176
0.79
0.33
1.1
1.1
—
—
—
0
0
18
219
0.82
0.32
1.0
1.1
1.48
5.00
u/ml
—
10
85
45
397
1.13
0.32
5.5
6.1
0.22
0.36
g/l
1.00
34
245
23
271
0.84
0.30
2.0
3.0
33.89
256.16
e6/l
1.90
18
208
23
271
0.84
0.30
2.0
3.0
1.47
5.13
e6/l
2.45
17
202
27
230
1.17
0.30
1.1
1.1
—
—
—
0
0
796
7821
1.05
0.30
4.7
4.3
2.65
2.80
mmol/l
4.80
751
7312
7
55
1.27
0.30
1.0
1.2
—
—
—
0
0
53
585
0.90
0.29
1.8
1.9
—
—
—
0
0
14
111
1.26
0.29
7.1
4.6
22.71
26.29
umol/l
1.37
14
111
40
353
1.13
0.29
1.0
1.1
—
—
—
0
0
298
2865
1.05
0.29
1.4
1.6
0.71
2.99
u/ml
6.50
71
638
23
194
1.19
0.28
1.8
1.2
—
—
—
0
0
8
62
1.29
0.28
1.0
1.1
—
—
—
0
0
14
171
0.81
0.27
2.4
3.9
—
—
—
0
0
53
480
1.11
0.26
1.7
1.7
—
—
—
0
0
79
730
1.08
0.26
1.5
1.4
—
—
—
0
0
366
3545
1.04
0.26
3.5
3.3
5.97
6.02
ph
0.12
30
348
9
74
1.21
0.25
1.1
1.1
—
—
—
0
0
751
7384
1.04
0.25
4.0
3.6
1.20
1.25
mmol/l
1.53
708
6895
36
401
0.89
0.24
2.7
2.3
—
—
—
0
0
12
147
0.81
0.24
2.4
3.0
—
—
—
0
0
10
125
0.80
0.23
2.1
1.7
—
—
—
0
0
30
265
1.13
0.23
1.2
1.2
—
—
—
0
0
5
39
1.28
0.23
3.4
2.4
743.00
615.28
ml
—
5
25
109
1147
0.94
0.22
1.2
1.2
—
—
—
0
0
30
266
1.13
0.22
1.2
1.2
—
—
—
0
0
203
2098
0.96
0.22
1.9
2.0
—
—
—
0
0
216
2078
1.04
0.21
1.5
1.7
1.37
1.38
mmol/l
0.03
183
1801
0
10
0.00
0.21
0.0
1.5
—
—
—
0
0
0
11
0.00
0.21
0.0
2.8
—
—
—
0
0
35
314
1.11
0.21
2.1
2.0
—
—
—
0
0
280
2872
0.96
0.21
2.4
2.5
—
—
—
0
0
23
261
0.88
0.21
1.6
1.4
—
—
—
0
0
0
12
0.00
0.21
0.0
1.0
—
—
—
0
0
0
12
0.00
0.21
0.0
1.7
—
—
—
0
0
23
260
0.88
0.20
1.5
1.4
—
—
—
0
0
0
14
0.00
0.20
0.0
1.1
—
—
—
0
0
6
50
1.20
0.19
1.0
1.2
—
—
—
0
0
144
1376
1.05
0.19
1.3
1.2
9.29
9.49
u/ml
0.01
51
518
780
7695
1.03
0.19
4.3
3.9
1.43
1.47
mmol/l
2.37
738
7204
11
90
1.22
0.18
1.3
1.2
—
—
—
0
0
24
268
0.89
0.18
1.5
1.5
—
—
—
0
0
13
109
1.19
0.18
1.8
2.1
—
—
—
0
0
7
59
1.18
0.18
1.1
1.2
—
—
—
0
0
43
395
1.09
0.18
1.4
1.3
—
—
—
0
0
23
257
0.89
0.17
1.8
3.1
—
—
—
0
0
15
128
1.17
0.17
1.5
1.3
—
—
—
0
0
12
141
0.85
0.17
1.0
1.3
3.93
24.63
u/ml
—
6
112
55
584
0.94
0.16
1.7
1.9
—
—
—
0
0
11
92
1.19
0.15
1.2
1.1
183.00
222.88
mg/l
0.62
11
83
59
554
1.06
0.15
2.2
2.3
10344.75
4391.71
u/l
0.48
19
211
9
82
1.09
0.15
1.7
1.6
—
—
—
0
0
9
82
1.09
0.15
3.2
1.9
—
—
—
0
0
11
128
0.85
0.14
1.4
4.2
—
—
—
0
0
188
1924
0.97
0.14
4.2
3.6
1.01
1.02
kg/l
0.70
25
295
56
590
0.94
0.13
1.9
1.9
—
—
—
0
0
141
1361
1.04
0.13
4.1
4.1
1.63
2.16
ug/l
1.04
120
1245
162
1661
0.97
0.13
1.8
1.7
—
—
—
0
0
439
4313
1.02
0.13
4.1
3.5
0.00
0.00
estimate
0.50
84
837
21
189
1.11
0.13
1.2
1.2
—
—
—
0
0
56
588
0.95
0.12
1.7
1.9
—
—
—
0
0
248
2421
1.03
0.12
3.7
3.7
7.66
7.78
mmol/l
0.15
215
2129
142
1457
0.97
0.12
2.0
2.9
117.73
101.61
ug/g
0.26
105
1176
12
136
0.88
0.11
1.1
1.3
—
—
—
0
0
18
162
1.11
0.11
1.1
1.2
—
—
—
0
0
11
95
1.16
0.11
1.8
1.7
—
—
—
0
0
54
564
0.95
0.10
1.2
1.2
—
—
—
0
0
20
182
1.10
0.10
2.0
1.4
0.75
0.33
nmol/l
0.34
14
148
29
309
0.93
0.10
1.6
1.7
—
—
—
0
0
44
461
0.95
0.09
1.9
1.8
—
—
—
0
0
75
721
1.04
0.09
4.9
3.8
—
—
—
0
0
55
572
0.96
0.09
1.2
1.3
15.28
38.11
au/ml
—
5
28
52
496
1.05
0.09
2.0
1.9
9.14
7.83
u/l
0.32
32
330
6
56
1.07
0.08
1.3
2.4
—
—
—
0
0
5
64
0.78
0.08
2.8
1.6
5.38
6.11
mmol/l
—
5
47
61
630
0.96
0.08
1.8
1.7
17.43
20.33
iu/l
0.35
48
476
16
146
1.09
0.07
1.0
1.1
—
—
—
0
0
228
2239
1.02
0.07
4.2
3.8
0.00
0.00
estimate
1.08
78
789
30
283
1.06
0.07
1.2
1.2
—
—
—
0
0
11
98
1.12
0.07
1.0
1.0
164.27
162.31
g/l
0.12
11
98
77
789
0.97
0.07
2.6
2.7
0.84
0.69
ug/l
0.25
50
451
63
608
1.03
0.07
2.2
2.2
8.90
11.32
nmol/l
1.30
55
555
8
93
0.86
0.06
1.9
1.4
387.25
494.59
pmol/l
—
8
83
16
147
1.09
0.06
1.8
4.7
—
—
—
0
0
20
213
0.93
0.06
2.8
2.5
—
—
—
0
0
34
354
0.96
0.06
1.7
1.9
281.52
195.46
u/ml
0.79
21
174
374
3698
1.01
0.05
3.1
2.8
74.92
74.13
nmol/l
0.22
337
3399
15
139
1.08
0.05
3.1
2.5
—
—
—
0
0
65
632
1.03
0.05
2.1
2.3
12.22
18.92
au/ml
—
5
46
435
4357
0.99
0.04
4.1
3.5
0.00
0.00
estimate
0.50
80
788
431
4317
0.99
0.04
5.7
4.9
0.00
0.00
estimate
0.50
82
810
87
853
1.02
0.03
1.4
1.3
—
—
—
0
0
13
121
1.07
0.03
1.2
1.5
—
—
—
0
0
10
107
0.93
0.02
1.0
1.1
—
—
—
0
0
20
206
0.97
0.01
1.1
1.2
—
—
—
0
0
13
135
0.96
0.00
1.2
1.1
—
—
—
0
0
119
1185
1.00
0.00
1.6
1.6
—
—
—
0
0
30
299
1.00
0.00
2.1
2.1
91.60
98.21
u/ml
—
5
37
29
285
1.01
0.00
2.2
2.1
—
—
—
0
0
57
565
1.01
0.00
1.4
1.4
—
—
—
0
0
79
792
0.99
0.00
2.7
2.3
34.77
33.02
u/l
0.13
71
657
19
194
0.98
0.00
1.1
1.7
0.26
0.73
g/l
4.73
14
157
0
6
0.00
0.00
0.0
2.2
—
178.83
—
0
6
6
67
0.89
0.00
1.7
3.4
50.00
55.12
%
—
6
59
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
6
61
0.98
0.00
1.0
1.1
—
—
—
0
0
0
6
0.00
0.00
0.0
1.2
—
—
—
0
0
6
63
0.95
0.00
2.8
3.5
47.70
15.72
mg/l
—
6
43
6
63
0.95
0.00
1.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.0
—
—
—
0
0
8
86
0.93
-0.00
1.0
1.3
—
—
—
0
0
5
55
0.91
-0.00
3.4
3.0
729.80
877.44
u/ml
—
5
55
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
2.82
—
0
8
9
95
0.94
-0.00
1.0
1.2
—
—
—
0
0
8
79
1.01
-0.00
2.3
1.7
119.38
126.72
ng/l
—
8
71
0
7
0.00
-0.00
0.0
1.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
3.6
—
—
—
0
0
6
62
0.96
-0.00
1.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.4
—
—
—
0
0
0
8
0.00
-0.00
0.0
1.0
—
—
—
0
0
9
94
0.95
-0.00
1.2
1.3
—
—
—
0
0
0
7
0.00
-0.00
0.0
1.1
—
274.00
—
0
7
0
7
0.00
-0.00
0.0
1.3
—
35.29
—
0
7
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
6
59
1.01
-0.00
1.0
2.2
7.65
3.04
nmol/l
—
6
59
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
7
0.00
-0.00
0.0
4.9
—
—
—
0
0
0
5
0.00
-0.00
0.0
5.6
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.2
—
—
—
0
0
0
5
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0
0
9
0.00
-0.00
0.0
1.0
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded (different definition than used in FinnGen).

Relationships between endpoints

Index endpoint: Q17_ATRIAL_SEPTAL_DEFECT_SECUNDUM_TYPE – Atrial septal defect, secundum type

GWS hits: 2

This endpoint is excluded (different definition than used in FinnGen).