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Personal history of allergy to drugs, medicaments and biological substances

Z21_PERSONAL_HISTORY_ALLERGY_DRUGS_MEDICAM_BIOLO_SUBST

Endpoint definition

Report an error or suggest an improvement for this endpoint codes

Endpoint definition steps

FinnGen

Phenotype data

520210

1. Apply sex-specific rule

None

520210

2. Check conditions

None

520210

3. Check pre-conditions, main-only, mode, registry filters

Registry filters:

  • Hospital discharge: ICD-10 Z88
  • Cause of death: ICD-10 Z88

2 out of 7 registries used, show all original rules.

403

4. Check minimum number of events

None

403

5. Include endpoints

None

403

6. Filter based on genotype QC (FinnGen only)

403

Extra metadata

Level in the ICD hierarchy
3
First used in FinnGen datafreeze
DF4
Parent code in ICD-10
Z[8-9]

Case counts by codes

FinnGen case counts by registry codes:

generic upset plot

Upset plot

Full data table

Summary Statistics

-FinRegistry-

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

-FinnGen-

Key figures

All Female Male
Number of individuals 403 293 110
Unadjusted period prevalence (%) 0.09 0.10 0.05
Median age at first event (years) 53.00 51.81 56.16

-FinnGen-

Age distribution of first events

01020304050607080900102030405060708090AgeIndividuals

-FinnGen-

Year distribution of first events

197019751980198519901995200020052010201520202023020406080100120140YearIndividuals

-FinnGen-

Cumulative Incidence Function

Not a core endpoint, no data to show.

CodeWAS (R11)

CodeWAS is a tool for exploring the associations between an endpoint and all of the medical codes and drug codes.

This is a new tool, please reach out using the contact form for feedback and improvement ideas.

First, a cohort is built by matching controls to the endpoint cases using year of birth and sex. Then, a Fisher test is done for all the medical codes and drug codes between the cases and controls of this cohort. Codes are reported in the table below if they have −log10(p-value) ≥ 6.

Matched cohort

Matched cases
350
Matched controls
3499
Code
Vocabulary
Description
Odds Ratio
-log10(p)
N matched cases
N matched controls
Z88.6
ICD-10 Finland
Personal history of allergy to analgesic agent
+∞
211.6
181
*
J33.0
ICD-10 Finland
Polyp of nasal cavity
49.9
94.0
113
33
J32.4
ICD-10 Finland
Chronic pansinusitis
74.2
90.4
101
19
XQ800
NOMESCO Finland
Prick test
17.4
88.1
151
146
DNB20
NOMESCO Finland
Endoscopic ethmoidectomy
44.3
84.3
104
33
C01CA24
ATC
epinephrine; parenteral
17.7
78.5
131
114
UDH02
NOMESCO Finland
Rhinopharyngoscopy
17.8
75.9
126
107
DMB20
NOMESCO Finland
Functional endoscopic opening of maxillary antrum
20.1
73.9
116
84
J45.1
ICD-10 Finland
Nonallergic asthma
16.8
73.5
125
112
J33.8
ICD-10 Finland
Other polyp of sinus
42.8
72.6
90
28
R03DC03
ATC
montelukast; oral
9.1
68.5
175
345
J45.0
ICD-10 Finland
Predominantly allergic asthma
12.4
68.3
136
170
DHB20
NOMESCO Finland
Polypectomy of internal nose
74.2
67.9
76
13
203
Kela drug reimbursment
Chronic asthma and similar chronic obstructive pulmonary diseases
8.6
67.1
182
392
R01AD08
ATC
fluticasone; nasal
6.9
60.5
218
678
Z88.8
ICD-10 Finland
Personal history of allergy to other drugs, medicaments and biological substances
+∞
59.1
55
*
J45.9
ICD-10 Finland
Asthma, unspecified
7.8
58.1
163
352
H02AB06
ATC
prednisolone; systemic
6.1
52.8
254
1061
TDM10
NOMESCO Finland
Puncture of maxillary antrum
17.8
52.6
85
62
J32.0
ICD-10 Finland
Chronic maxillary sinusitis
11.2
50.2
102
124
Z88.1
ICD-10 Finland
Personal history of allergy to other antibiotic agents
+∞
46.9
44
*
DM1AD
NOMESCO Finland
CT of paranasal sinuses and face area
15.4
45.2
77
63
R03AC02
ATC
salbutamol; inhalant
5.3
42.1
274
1418
H02AB07
ATC
prednisone; oral
6.4
38.4
116
252
DPA30
NOMESCO Finland
Sphenotomy
51.4
37.9
45
10
R01AD05
ATC
budesonide; nasal
7.9
36.4
90
146
ZXA10
NOMESCO Finland
Bilateral
5.4
35.2
125
326
R03BB04
ATC
tiotropium bromide; inhalant
8.2
35.0
84
130
R03AK06
ATC
salmeterol and fluticasone; inhalant
5.8
34.5
113
267
Z01.5
ICD-10 Finland
Diagnostic skin and sensitization tests
6.2
31.7
95
199
R06AE07
ATC
cetirizine; oral
3.9
31.7
231
1165
R03BA02
ATC
budesonide; inhalant
4.7
31.2
127
376
H02AB04
ATC
methylprednisolone; systemic
5.3
30.4
106
265
R03BA05
ATC
fluticasone; inhalant
4.6
30.0
127
389
DPA25
NOMESCO Finland
Trephine of frontal sinus through nose
51.8
28.0
33
7
J46
ICD-10 Finland
Status asthmaticus
14.5
27.0
46
36
J33.9
ICD-10 Finland
Nasal polyp, unspecified
50.1
27.0
32
7
J45
ICD-10 Finland
Asthma
5.6
24.7
78
170
WX105
NOMESCO Finland
Surface analgesia on skin or mucosa
5.7
24.6
77
166
T78.4
ICD-10 Finland
Allergy, unspecified
8.3
24.5
56
78
N02AX02
ATC
tramadol; systemic, rectal
3.3
24.1
186
903
R03DA04
ATC
theophylline; systemic, rectal
10.0
24.0
49
56
R03AC13
ATC
formoterol; inhalant
9.0
23.5
51
65
Z88.9
ICD-10 Finland
Personal history of allergy to unspecified drugs, medicaments and biological substances
+∞
23.2
22
*
WX408
NOMESCO Finland
General anesthesy, balanced
3.5
23.0
139
557
WX002
NOMESCO Finland
Sedation and analgesia
4.1
22.8
103
324
R03AC12
ATC
salmeterol; inhalant
9.4
22.3
47
57
R06AX27
ATC
desloratadine; oral
3.2
21.8
156
703
R03AK07
ATC
formoterol and budesonide; inhalant
3.6
21.5
120
447
Z88.0
ICD-10 Finland
Personal history of allergy to penicillin
222.7
20.8
21
*
R01AD09
ATC
mometasone; nasal
3.0
20.8
218
1253
XQ820
NOMESCO Finland
Exposure to medicinal substance
111.4
19.8
21
*
GD1AA
NOMESCO Finland
Thorax X-ray examination
2.9
19.7
169
842
R06AX13
ATC
loratadine; oral
3.6
19.2
101
354
R03AC03
ATC
terbutaline; inhalant
3.9
19.1
90
288
R03AK08
ATC
formoterol and beclometasone; inhalant
8.8
18.9
41
52
R01AD12
ATC
fluticasone furoate; nasal
2.9
18.8
161
794
J01FA06
ATC
roxithromycin; oral
2.8
18.7
180
957
R4110
NOMESCO Finland
Physiotherapy
3.1
18.1
127
548
R06AE09
ATC
levocetirizine; oral
3.5
17.9
96
341
J01FF01
ATC
clindamycin; systemic
3.1
17.8
122
516
J01AA02
ATC
doxycycline; systemic
3.4
17.7
297
2190
ZXC95
NOMESCO Finland
Use of surgical navigator
18.2
17.7
27
16
DM1QA
NOMESCO Finland
Paranasal sinuses X-ray examination in one projection
7.1
17.2
43
68
4222
FHL
Endonasal etmoidectomy
66.7
16.9
19
*
Z88.4
ICD-10 Finland
Personal history of allergy to anaesthetic agent
+∞
16.8
16
*
Z01.8
ICD-10 Finland
Other specified special examinations
3.1
16.1
103
412
DM1AI
NOMESCO Finland
Cone beam CT of paranasal sinus
11.2
16.0
30
29
WX402
NOMESCO Finland
General anaesthesia
3.3
15.8
91
337
J01FA09
ATC
clarithromycin; systemic
2.7
15.5
150
771
GX1L5
NOMESCO Finland
Exhaled nitric oxide analysis
47.2
15.2
18
*
M01AE01
ATC
ibuprofen; systemic, rectal
0.4
14.9
222
2890
J45.8
ICD-10 Finland
Mixed asthma
7.7
14.7
34
48
WX404
NOMESCO Finland
Intravenous generell anesthesy
2.9
14.6
101
423
Y57
ICD-10 Finland
Adverse effects in the therapeutic use of other and unspecified drugs and medicaments
12.1
14.5
26
23
J01FA10
ATC
azithromycin; systemic
2.5
14.5
248
1716
DHA10
NOMESCO Finland
Biopsy of cavity of nose
25.0
13.9
19
8
Z96.1
ICD-10 Finland
Presence of intraocular lens
14.4
13.9
23
17
D72.1
ICD-10 Finland
Eosinophilia
55.7
13.9
16
*
N02BE01
ATC
paracetamol; systemic, rectal
3.3
13.7
311
2484
4711A
ICD-9 Finland
Nasal polyps, Polypoid sinus degeneration
78.3
13.7
15
*
NK6QA
NOMESCO Finland
Measurement of bone density from tow or more locations with X-ray
5.3
13.7
42
87
J01MA14
ATC
moxifloxacin; systemic
4.2
13.6
53
141
R03BA08
ATC
ciclesonide; inhalant
4.2
13.5
54
147
L27.0
ICD-10 Finland
Generalized skin eruption due to drugs and medicaments
15.9
13.3
21
14
J33
ICD-10 Finland
Nasal polyp
41.8
13.3
16
*
N02AA59
ATC
codeine, combinations excl. psycholeptics; systemic
2.4
13.2
183
1112
R03BA01
ATC
beclometasone; inhalant
3.2
13.1
75
272
DHB50
NOMESCO Finland
Turbinoplasty
7.8
12.8
29
40
R01AD58
ATC
fluticasone, combinations; inhalant, nasal
2.5
12.6
116
570
R01BA52
ATC
pseudoephedrine, combinations; oral
2.4
12.5
139
750
J32.2
ICD-10 Finland
Chronic ethmoidal sinusitis
16.7
12.3
19
12
TPH04
NOMESCO Finland
Cathetrisation of vein
2.9
12.1
83
341
ZXA05
NOMESCO Finland
Left side
2.7
11.9
95
427
R06.0
ICD-10 Finland
Dyspnoea
2.6
11.8
99
458
R02
ICPC
Shortness of breath/dyspnoea
3.6
11.8
55
171
J06.9
ICD-10 Finland
Acute upper respiratory infection, unspecified
2.2
11.6
187
1195
R96
ICPC
Asthma
3.9
11.6
49
140
R03AK11
ATC
formoterol and fluticasone; inhalant
7.7
11.5
26
36
DMB00
NOMESCO Finland
Endonasal trephine of maxillary antrum
36.3
11.3
14
*
T78.2
ICD-10 Finland
Anaphylactic shock, unspecified
13.3
11.3
19
15
R03DC01
ATC
zafirlukast; oral
11.7
11.2
20
18
Z51.6
ICD-10 Finland
Desensitization to allergens
12.5
11.0
19
16
J01.0
ICD-10 Finland
Acute maxillary sinusitis
2.4
10.8
111
567
N02AJ06
ATC
codeine and paracetamol; systemic
2.2
10.6
148
877
R01AD01
ATC
beclometasone; nasal
2.7
10.5
77
327
S01GX01
ATC
cromoglicic acid; ophthalmic
2.5
10.5
96
462
J33.1
ICD-10 Finland
Polypoid sinus degeneration
+∞
10.5
10
*
J18.9
ICD-10 Finland
Pneumonia, unspecified
2.7
10.4
78
333
J32.8
ICD-10 Finland
Other chronic sinusitis
24.2
10.3
14
6
A02BC02
ATC
pantoprazole; systemic
2.1
10.2
232
1680
Z03.89
ICD-10 Finland
Observation for other suspected diseases and conditions
2.9
10.2
65
253
ZX112
NOMESCO Finland
Subcutaneous
9.6
10.2
20
22
R06AX22
ATC
ebastine; oral
2.5
10.1
92
441
J01MA02
ATC
ciprofloxacin; systemic
2.2
10.1
139
813
T88.6
ICD-10 Finland
Anaphylactic shock due to adverse effect of correct drug or medicament properly administered
41.3
10.0
12
*
R03BB01
ATC
ipratropium bromide; inhalant
7.0
9.6
23
35
R03AL02
ATC
salbutamol and ipratropium bromide; inhalant
15.6
9.6
15
10
H65.3
ICD-10 Finland
Chronic mucoid otitis media
6.5
9.6
24
39
J01CR02
ATC
amoxicillin and beta-lactamase inhibitor; systemic
2.0
9.5
204
1422
XQ801
NOMESCO Finland
Intracutantest
102.7
9.5
10
*
Z95.0
ICD-10 Finland
Presence of electronic cardiac devices
+∞
9.4
9
*
XG474
NOMESCO Finland
Exhalation nntrogen oxide
6.0
9.4
25
44
Z01.7
ICD-10 Finland
Laboratory examination
3.0
9.3
56
209
GD1DD
NOMESCO Finland
High resolution CT examination of lungs
5.2
9.0
27
55
DFF00
NOMESCO Finland
Pure tone audiometry
3.8
9.0
38
109
GD1ED
NOMESCO Finland
Extensive high resolution CT examination of lungs
8.3
9.0
19
24
X59
ICD-10 Finland
Exposure to unspecified factor
2.5
9.0
80
377
A02BC05
ATC
esomeprazole; systemic
2.1
9.0
146
905
R03AK10
ATC
vilanterol and fluticasone furoate; inhalant
5.0
9.0
28
60
DM1AA
NOMESCO Finland
Paranasal sinuses X-ray examination without contrast
5.6
8.9
25
47
J01MA12
ATC
levofloxacin; systemic
2.6
8.8
69
301
FM1AE
NOMESCO Finland
Standard cardiac ultrasound examination
2.9
8.7
55
213
GD1PA
NOMESCO Finland
X-ray examination of the lungs in one projection
4.1
8.6
33
87
R03AK04
ATC
salbutamol and sodium cromoglicate; inhalant
16.8
8.6
13
8
J01.9
ICD-10 Finland
Acute sinusitis, unspecified
5.3
8.5
25
50
J34.2
ICD-10 Finland
Deviated nasal septum
4.3
8.5
31
78
DJD20
NOMESCO Finland
Plastic repair of septum of nose
5.5
8.5
24
46
L50.9
ICD-10 Finland
Urticaria, unspecified
5.0
8.4
26
55
R50.9
ICD-10 Finland
Fever, unspecified
2.7
8.4
59
243
R10.4
ICD-10 Finland
Other and unspecified abdominal pain
2.0
8.4
142
888
E27.3
ICD-10 Finland
Drug-induced adrenocortical insufficiency
+∞
8.4
8
*
J01DA06
ATC
[U] cefuroxime; systemic
2.5
8.4
67
298
XF400
NOMESCO Finland
ECG with 12 standard connections
2.7
8.2
60
250
J01DB01
ATC
cefalexin; oral
2.3
8.2
295
2456
E0000UV
ATC
NA
2.0
7.9
151
980
J01DC02
ATC
cefuroxime; systemic
3.6
7.9
35
105
4730A
ICD-9 Finland
Chronic sinusitis, Maxillary
11.2
7.9
14
13
WX110
NOMESCO Finland
Local anesthesy
2.0
7.8
255
2013
R53
ICD-10 Finland
Malaise and fatigue
2.3
7.8
80
403
A12AX
ATC
Calcium, combinations with vitamin D and/or other drugs
2.0
7.7
112
656
Z04.8
ICD-10 Finland
Examination and observation for other specified reasons
2.6
7.7
55
230
WX700
NOMESCO Finland
Respiratory and circulatory monitoring
2.6
7.6
58
251
DCA10
NOMESCO Finland
Paracentesis of tympanic membrane
10.4
7.6
14
14
C03CA01
ATC
furosemide; systemic
2.4
7.5
67
315
R10.1
ICD-10 Finland
Pain localized to upper abdomen
2.4
7.5
67
316
JN3AE
NOMESCO Finland
Abdominal ultrasound examination
2.7
7.5
50
200
R03DX09
ATC
mepolizumab; parenteral
81.8
7.4
8
*
297
Kela drug reimbursment
NA
81.8
7.4
8
*
3028
Kela drug reimbursment
Mepolizumab
81.8
7.4
8
*
J02AC02
ATC
itraconazole; systemic
2.2
7.4
77
390
XF404
NOMESCO Finland
Ambulatory ECG
3.2
7.4
37
123
J30.10
ICD-10 Finland
Allergic rhinitis due to pollen
3.4
7.3
35
112
L50.0
ICD-10 Finland
Allergic urticaria
6.0
7.3
19
33
DNB10
NOMESCO Finland
Endonasal ethmoidectomy
+∞
7.3
7
*
Z88.2
ICD-10 Finland
Personal history of allergy to sulfonamides
+∞
7.3
7
*
D07AC01
ATC
betamethasone; topical
2.0
7.2
120
737
4931A
ICD-9 Finland
Asthma, Intrinsic asthma[INTRINSIC ASTHMA SINE EXACERBATIONE]
20.5
7.2
10
5
DCA20
NOMESCO Finland
Insertion of ventilating tube through tympanic membrane
4.9
7.2
22
47
ZXA00
NOMESCO Finland
Right side
2.1
7.0
91
504
N02AE01
ATC
buprenorphine; parenteral, sublingual, transdermal
2.9
7.0
42
158
M79.6
ICD-10 Finland
Pain in limb
1.9
7.0
128
812
J02AC01
ATC
fluconazole; systemic
1.8
6.9
165
1144
4939X
ICD-9 Finland
Asthma, unspecified[ASTHMA BRONCHIALE NUD]
14.1
6.9
11
8
X49
ICD-10 Finland
Accidental poisoning by and exposure to other and unspecified chemicals and noxious substances
14.1
6.9
11
8
L30.9
ICD-10 Finland
Dermatitis, unspecified
2.2
6.8
71
357
I49.9
ICD-10 Finland
Cardiac arrhythmia, unspecified
2.8
6.8
44
173
D07AB08
ATC
desonide; topical
2.7
6.8
47
192
4700A
ICD-9 Finland
Deflected nasal septum[DEFORMATIO SEPTI NASI]
17.1
6.8
10
6
H04.10
ICD-10 Finland
Dry eye syndrome
2.8
6.8
43
167
UDM02
NOMESCO Finland
Sinoscopy
6.7
6.7
16
25
E66.8
ICD-10 Finland
Other obesity
3.5
6.6
29
87
T88.7
ICD-10 Finland
Unspecified adverse effect of drug or medicament
9.0
6.6
13
15
N03AX16
ATC
pregabalin; oral
2.1
6.6
79
423
Z71.8
ICD-10 Finland
Other specified counselling
2.0
6.6
93
534
J30.3
ICD-10 Finland
Other allergic rhinitis
4.1
6.5
24
62
R06AX26
ATC
fexofenadine; oral
3.0
6.4
36
127
DPA20
NOMESCO Finland
Trephine of frontal sinus
71.1
6.4
7
*
J01EE02
ATC
sulfadiazine and trimethoprim; systemic
1.9
6.4
109
670
T78.3
ICD-10 Finland
Angioneurotic oedema
8.4
6.4
13
16
TQX10
NOMESCO Finland
Biopsy of skin and subcutaneous tissue
2.9
6.4
37
136
J15.9
ICD-10 Finland
Bacterial pneumonia, unspecified
3.2
6.3
32
108
4221
FHL
Polyp removal from the nasal cavity, sinus puncture or irrigation, or biopsy under general anesthesia or operating room
18.4
6.3
9
5
T78.1
ICD-10 Finland
Other adverse food reactions, not elsewhere classified
+∞
6.3
6
*
Z88.7
ICD-10 Finland
Personal history of allergy to serum and vaccine
+∞
6.3
6
*
R10.3
ICD-10 Finland
Pain localized to other parts of lower abdomen
2.0
6.3
94
549
UJD10
NOMESCO Finland
Esophagoscopy, gastroscopy and duodenoscopy
1.9
6.2
96
569
J20.9
ICD-10 Finland
Acute bronchitis, unspecified
2.2
6.2
67
340
XF600
NOMESCO Finland
Bloodpressure measurement
3.3
6.2
29
92
4224
FHL
Endonasal anthrostomy
10.3
6.1
11
11
49300
ICD-8 Finland
Asthma, bronchiale
6.2
6.1
15
25
J01DA08
ATC
[U] cefaclor; oral
2.3
6.0
57
273

LabWAS

OMOP Concept
People with measurements
Mean N measurements
Mean measured value
(ID) Name
N Cases
N Controls
OR
-log10(p)
cases
controls
cases
controls
unit
-log10(p)
N cases
N controls
164
231
11.29
120.35
2.0
1.2
227.70
283.61
u/ml
0.22
157
217
80
77
12.72
75.18
1.5
1.1
0.49
2.83
u/ml
0.85
66
29
76
70
13.15
73.42
1.4
1.1
1.68
6.06
u/ml
1.40
65
37
72
62
13.92
72.50
1.4
1.0
0.53
3.09
u/ml
0.86
42
12
273
1014
6.25
70.91
7.1
5.5
—
—
—
0
0
73
68
12.89
69.90
1.5
1.1
0.33
0.74
u/ml
0.76
61
30
117
216
7.22
64.76
1.8
1.4
—
—
—
0
0
139
330
5.90
58.89
1.7
1.3
—
—
—
0
0
323
1613
6.05
53.00
8.2
5.6
0.57
0.55
e9/l
0.89
274
1424
306
1465
5.52
52.88
8.4
5.6
0.76
0.68
%
2.14
297
1373
323
1621
6.00
52.44
8.2
5.7
0.05
0.04
e9/l
4.62
274
1431
135
343
5.41
52.36
2.4
1.4
—
—
—
0
0
309
1513
5.47
51.25
8.4
5.6
4.36
2.73
%
13.06
299
1421
327
1679
6.02
50.98
8.5
6.2
0.31
0.18
e9/l
14.84
283
1509
308
1525
5.33
49.77
8.6
5.8
8.00
8.33
%
1.53
299
1440
323
1672
5.69
48.97
8.4
5.7
2.02
2.00
e9/l
0.09
281
1509
296
1438
4.99
48.57
10.1
8.0
0.00
0.00
e9/l
0.82
223
1195
209
789
4.43
48.40
7.1
6.3
—
—
—
0
0
41
28
16.19
46.58
1.3
1.0
1.11
0.08
u/ml
—
21
10
307
1563
5.05
46.54
8.4
5.4
55.60
56.53
%
0.78
298
1481
308
1578
5.04
46.14
8.6
5.6
28.29
29.38
%
1.21
299
1489
339
1885
6.03
45.31
11.2
8.9
4.09
4.00
e9/l
0.31
291
1662
46
48
10.69
40.23
1.4
1.0
2.34
4.64
u/ml
0.43
39
15
47
55
9.54
37.75
1.4
1.0
1.42
3.80
u/ml
0.43
40
18
124
375
4.33
37.44
2.8
1.9
—
—
—
0
0
41
47
9.60
33.36
1.4
1.0
0.04
0.83
u/ml
—
34
9
164
751
3.00
24.46
4.7
3.2
93.03
96.28
%
0.81
159
729
166
791
2.87
22.68
4.0
2.6
0.19
0.39
e6/l
1.40
117
594
102
382
3.24
21.23
2.2
1.3
—
—
—
0
0
162
792
2.75
20.70
4.1
2.6
—
—
—
0
0
26
31
8.90
20.35
1.8
1.1
—
—
—
0
0
26
31
8.90
20.35
1.6
1.1
0.33
0.42
g/l
0.41
21
24
26
31
8.90
20.35
1.6
1.1
2.90
3.01
g/l
0.08
21
24
26
31
8.90
20.35
1.6
1.1
5.97
6.39
g/l
0.29
21
24
168
861
2.63
19.25
4.2
2.7
15.53
75.23
e6/l
2.37
123
663
136
635
2.72
18.71
5.6
3.8
—
—
—
0
0
24
29
8.74
18.57
2.5
2.2
—
—
—
0
0
31
51
6.50
18.39
2.0
1.7
1.01
0.85
g/l
0.23
25
44
190
1057
2.51
18.04
4.8
3.1
16.16
61.77
e6/l
3.53
131
727
79
279
3.28
17.91
2.9
1.9
26.94
32.66
u/l
0.82
66
235
100
420
2.84
16.65
3.2
2.6
4.70
3.01
e6/l
0.53
43
226
105
464
2.71
15.77
3.0
2.4
0.86
1.03
e6/l
0.28
47
265
216
1340
2.32
15.28
2.4
1.9
—
—
—
0
0
107
488
2.62
15.02
5.1
2.8
1375.20
375.11
ng/l
0.37
72
325
155
841
2.37
14.92
3.9
3.3
7.41
7.40
ph
0.78
27
139
237
1542
2.30
14.80
6.5
5.6
10.88
10.99
umol/l
0.04
225
1464
121
605
2.43
13.85
3.5
2.2
6.29
5.98
e6/l
0.11
103
526
294
2144
2.37
13.35
4.1
3.1
—
—
—
0
0
61
225
3.02
12.66
1.2
1.2
—
—
—
0
0
165
973
2.18
12.54
3.4
2.9
2.35
2.36
mmol/l
0.28
149
863
190
1194
2.12
12.16
5.0
4.0
36.33
36.50
g/l
0.18
175
1111
53
192
3.03
11.32
9.7
8.2
—
—
—
0
0
48
167
3.13
10.98
1.1
1.1
—
—
—
0
0
41
130
3.40
10.89
7.7
7.5
25.45
25.05
mmol/l
0.36
41
130
129
724
2.15
10.84
1.8
1.4
2.16
2.25
g/l
0.34
82
457
379
3243
3.83
10.54
24.1
11.5
40.39
40.21
%
0.23
321
2565
40
128
3.36
10.47
1.3
1.2
—
—
—
0
0
60
245
2.70
10.26
3.2
2.0
10.52
10.16
g/l
0.25
55
224
74
335
2.48
10.26
3.2
2.4
5.03
7.65
umol/l
1.10
63
289
83
396
2.38
10.26
1.9
1.9
29.66
29.53
s
0.07
83
386
309
2417
2.19
10.14
5.6
3.7
11.37
10.32
mm/h
0.83
295
2246
386
3366
4.48
9.91
21.7
10.5
24.10
20.57
mg/l
1.09
331
2559
67
296
2.52
9.76
2.6
2.1
304.29
372.92
nmol/l
2.38
62
272
95
495
2.20
9.48
3.0
2.7
2.44
2.44
mmol/l
0.12
79
431
15
23
6.74
9.41
1.5
1.2
—
—
—
0
0
166
1067
1.95
9.32
4.1
3.1
26.14
29.31
u/l
1.71
160
1019
184
1235
1.90
8.98
6.7
5.1
1.21
1.22
mmol/l
2.14
175
1132
198
1362
1.89
8.95
7.5
5.7
1.21
1.22
mmol/l
1.00
170
1168
121
706
2.02
8.91
2.1
1.7
1.39
1.02
mg/l
0.22
96
544
296
2330
2.02
8.80
3.3
2.8
38.48
42.10
u/l
0.58
287
2213
101
554
2.10
8.78
3.7
2.2
542.94
572.31
mosm/kgh2o
0.52
85
470
301
2404
2.00
8.30
9.4
6.6
74.31
77.19
u/l
0.79
289
2243
11
14
8.05
8.02
2.2
2.4
657.36
533.07
u/ml
0.18
11
14
14
26
5.54
7.30
1.1
1.1
0.12
0.15
u/ml
—
7
8
143
937
1.82
7.16
3.2
2.3
50.23
56.35
u/l
1.73
134
878
22
61
3.76
7.12
3.0
3.7
4.78
4.31
e9/l
0.39
22
61
22
62
3.70
6.97
3.0
4.2
59.59
57.13
%
0.48
22
62
69
361
2.10
6.68
2.2
2.0
2.40
2.40
g/l
0.00
61
332
12
21
5.86
6.62
1.5
2.5
1.73
1.49
e9/l
—
5
11
158
1088
1.74
6.56
2.0
1.8
94.73
97.47
pmol/l
0.28
85
581
16
37
4.46
6.55
6.2
2.8
8.66
8.85
kpa
0.17
16
37
16
37
4.46
6.55
6.3
2.8
5.21
5.03
kpa
0.45
16
37
6
0
+∞
6.26
1.2
0.0
—
—
—
0
0
117
749
1.79
6.19
3.0
2.2
11495.37
5811.11
umol/l
0.29
99
655
53
260
2.20
6.03
9.2
8.1
1.82
1.40
mmol/l
0.27
41
206
180
1311
1.67
5.93
2.4
2.2
72.23
76.50
nmol/l
1.33
161
1198
146
1007
1.71
5.90
9.4
5.6
1.11
1.11
inr
0.01
47
314
113
732
1.76
5.68
2.8
3.2
—
—
—
0
0
42
192
2.33
5.64
1.3
1.2
—
—
—
0
0
71
399
1.95
5.61
2.3
2.0
13.14
14.13
umol/l
0.55
66
370
12
25
4.92
5.53
1.2
1.1
—
—
—
0
0
62
336
2.00
5.43
2.4
2.1
19.90
23.91
%
1.79
53
296
30
119
2.64
5.43
10.0
9.0
—
—
—
0
0
269
2211
1.65
5.23
6.1
3.7
—
—
—
0
0
23
81
2.95
5.17
3.1
3.0
—
—
—
0
0
15
40
3.86
5.13
5.4
2.2
—
—
—
0
0
8
6
13.57
5.10
1.0
1.2
—
—
—
0
0
79
475
1.82
5.06
1.6
1.3
326.67
590.89
titre
1.28
18
101
307
2625
1.71
4.99
4.8
4.0
14.33
14.51
pmol/l
0.66
287
2423
219
1724
1.59
4.98
6.7
4.0
6.42
6.51
mmol/l
0.29
206
1585
46
231
2.12
4.94
3.8
3.2
—
—
—
0
0
33
145
2.39
4.85
12.1
9.9
93.04
93.97
%
0.25
33
145
128
890
1.64
4.85
3.0
2.4
—
—
—
0
0
48
248
2.06
4.79
2.1
2.3
0.23
0.22
g/l
0.32
43
234
15
43
3.58
4.66
2.5
1.6
—
—
—
0
0
133
945
1.61
4.58
2.5
2.0
—
—
—
0
0
44
224
2.08
4.56
3.8
3.2
1.47
2.15
mmol/l
0.61
39
166
102
681
1.67
4.48
2.3
1.9
2.89
2.86
mg/l
0.04
90
586
16
50
3.29
4.38
1.7
2.7
—
—
—
0
0
43
221
2.06
4.35
1.3
1.3
18.61
25.30
iu/l
0.99
35
188
114
793
1.61
4.24
2.0
1.9
—
—
—
0
0
47
253
1.97
4.20
3.8
2.7
1.91
1.75
%
0.33
42
235
26
110
2.46
4.16
1.1
1.2
—
—
—
0
0
196
1548
1.52
4.11
3.6
2.6
139.93
84.66
ug/l
0.70
181
1444
91
605
1.65
4.03
1.6
1.4
18.41
21.13
nmol/l
1.42
79
515
383
3570
2.47
4.00
13.3
8.9
25.62
26.02
u/l
0.20
377
3459
48
266
1.91
3.95
1.4
1.4
—
—
—
0
0
115
817
1.57
3.87
5.8
4.6
—
—
—
0
0
382
3563
2.38
3.87
16.2
9.9
—
—
—
0
0
344
3104
1.74
3.80
5.8
4.6
1.73
2.21
mu/l
0.67
329
2877
365
3352
1.94
3.80
22.7
11.3
3.89
3.94
mmol/l
3.49
359
3252
13
39
3.41
3.79
2.7
2.3
17.68
16.31
%
—
5
22
198
1589
1.48
3.72
3.9
3.2
0.00
0.00
estimate
0.00
36
308
200
1610
1.48
3.69
5.9
4.3
0.00
0.00
estimate
0.50
37
314
8
12
6.77
3.69
2.8
4.5
173.63
106.92
nmol/l
—
8
12
11
30
3.74
3.66
1.2
1.1
0.45
0.54
u/ml
—
5
9
13
40
3.33
3.65
1.8
2.7
53.69
60.83
%
0.53
13
40
201
1626
1.47
3.59
3.9
3.2
0.00
0.01
estimate
0.50
36
305
26
119
2.27
3.53
2.1
1.6
—
—
—
0
0
48
277
1.83
3.50
1.2
1.2
157.93
163.29
iu/ml
0.03
12
114
38
203
1.96
3.48
2.0
2.2
66.86
67.83
g/l
0.30
32
188
38
203
1.96
3.48
3.1
3.0
84.38
65.10
ng/l
0.93
32
183
21
89
2.43
3.38
1.4
1.2
312.26
334.01
ug/g
—
10
50
7
10
7.10
3.37
1.3
1.0
—
—
—
0
0
49
288
1.80
3.37
1.2
1.1
—
—
—
0
0
23
102
2.33
3.36
1.2
1.1
—
—
—
0
0
66
424
1.67
3.32
1.2
1.2
—
—
—
0
0
47
274
1.81
3.32
23.4
13.6
1.08
1.18
inr
—
5
43
182
1466
1.44
3.21
4.2
3.7
—
—
—
0
0
13
44
3.02
3.16
1.0
1.0
1.26
1.43
g/l
0.91
13
38
37
203
1.91
3.15
3.9
3.3
4.14
4.63
pmol/l
3.56
32
181
8
16
5.08
3.06
1.4
1.0
—
—
—
0
0
73
491
1.59
3.06
1.8
2.3
89.75
117.23
ug/g
0.40
63
388
9
21
4.36
3.01
2.8
2.1
92.60
90.39
%
—
9
21
31
163
1.98
2.99
2.1
2.0
—
—
—
0
0
113
842
1.48
2.96
1.4
1.3
0.63
1.69
u/ml
1.31
25
236
133
1024
1.45
2.94
4.0
2.8
17.06
30.10
ng/l
1.50
75
592
28
144
2.01
2.88
3.1
5.3
—
—
—
0
0
70
473
1.58
2.88
1.6
1.4
—
—
—
0
0
345
3174
1.60
2.83
4.2
3.9
5.76
5.78
mmol/l
0.08
320
2931
16
65
2.52
2.82
1.2
1.3
—
—
—
0
0
31
169
1.90
2.71
1.4
1.6
404.37
295.47
mu/l
0.42
24
154
9
24
3.81
2.68
1.0
1.1
—
—
—
0
0
14
55
2.60
2.64
1.2
1.2
—
—
—
0
0
7
15
4.73
2.60
3.7
3.5
—
—
—
0
0
16
68
2.41
2.59
1.3
1.1
—
—
—
0
0
13
50
2.65
2.55
1.2
4.3
—
—
—
0
0
10
33
3.08
2.54
1.1
1.2
—
—
—
0
0
18
82
2.25
2.51
1.3
1.2
—
—
—
0
0
65
447
1.54
2.48
1.7
1.6
1132.34
1202.36
nmol/l
0.23
47
340
10
34
2.99
2.43
1.0
1.2
—
—
—
0
0
39
239
1.70
2.36
1.3
1.4
—
—
—
0
0
63
436
1.53
2.34
1.9
1.5
—
—
—
0
0
8
23
3.53
2.28
3.8
3.1
—
—
—
0
0
6
13
4.67
2.28
1.0
1.1
—
—
—
0
0
23
121
1.96
2.26
2.0
1.6
—
—
—
0
0
14
60
2.38
2.24
1.1
1.1
—
—
—
0
0
30
173
1.79
2.24
1.8
2.9
76.14
71.22
e9/l
0.26
18
126
24
129
1.91
2.22
1.3
1.2
—
—
—
0
0
11
42
2.66
2.20
1.4
1.4
—
—
—
0
0
15
68
2.25
2.13
1.3
1.1
—
—
—
0
0
107
834
1.39
2.13
1.7
1.6
1.38
1.41
mmol/l
0.15
92
719
12
49
2.49
2.12
1.1
1.2
—
—
—
0
0
8
25
3.24
2.10
2.5
1.6
—
—
—
0
0
8
25
3.24
2.10
2.5
1.6
—
—
—
0
0
8
25
3.24
2.10
2.5
1.6
—
—
—
0
0
8
25
3.24
2.10
2.5
1.6
—
—
—
0
0
11
245
0.43
2.08
3.1
3.4
—
—
—
0
0
353
3315
1.52
2.07
4.4
4.3
2.82
2.88
mmol/l
0.72
333
3090
6
15
4.04
2.04
1.8
1.2
—
—
—
0
0
85
644
1.41
1.99
1.4
1.3
15.62
32.19
iu/ml
2.40
22
213
17
85
2.04
1.93
2.1
5.4
0.22
0.20
g/l
0.06
12
35
50
348
1.50
1.83
1.3
1.3
—
—
—
0
0
39
258
1.57
1.79
4.1
4.1
32.61
24.24
ug/l
0.12
30
214
316
2933
1.36
1.76
5.7
4.7
38.71
38.60
mmol/mol
0.07
300
2756
9
36
2.53
1.75
2.2
2.2
—
—
—
0
0
13
61
2.17
1.73
1.2
1.2
3.17
8.04
u/ml
—
6
24
13
61
2.17
1.73
1.7
1.7
—
—
—
0
0
336
3152
1.40
1.72
3.5
3.5
1.29
1.26
mmol/l
0.34
317
2950
12
55
2.22
1.69
2.1
2.0
—
—
—
0
0
7
25
2.83
1.65
1.4
1.2
—
—
—
0
0
7
26
2.72
1.58
1.1
1.1
1.30
1.43
nmol/l
—
7
21
6
20
3.03
1.58
1.3
1.5
—
1872.60
—
0
5
82
642
1.35
1.57
1.9
1.6
—
—
—
0
0
52
378
1.43
1.55
1.3
1.2
—
—
—
0
0
28
178
1.62
1.53
1.7
1.4
—
—
—
0
0
21
124
1.73
1.50
1.6
1.5
—
—
—
0
0
37
254
1.50
1.47
1.8
1.6
—
—
—
0
0
7
28
2.53
1.46
1.6
1.2
—
—
—
0
0
21
126
1.70
1.43
2.0
2.8
0.57
0.64
%
0.43
21
121
344
3268
1.36
1.38
4.1
3.9
4.79
4.81
mmol/l
0.14
329
3076
9
41
2.22
1.38
1.4
1.9
—
—
—
0
0
6
23
2.63
1.37
1.8
3.3
9.38
11.36
%
—
6
23
20
120
1.70
1.37
1.5
1.4
—
—
—
0
0
20
120
1.70
1.37
1.5
1.4
—
—
—
0
0
343
3260
1.35
1.34
4.0
3.9
1.52
1.51
mmol/l
0.30
323
3053
9
42
2.17
1.34
1.8
2.0
—
—
—
0
0
9
42
2.17
1.34
1.1
1.3
—
—
nmol/l
—
0
0
39
277
1.45
1.33
4.7
3.2
—
—
—
0
0
21
129
1.66
1.32
2.0
2.7
1.03
1.33
%
1.05
21
129
28
186
1.54
1.30
1.7
1.4
—
—
—
0
0
28
186
1.54
1.30
1.7
1.4
—
—
—
0
0
28
186
1.54
1.30
1.7
1.4
—
—
—
0
0
23
146
1.61
1.29
1.3
1.4
262.64
265.38
miu/ml
—
9
76
6
25
2.42
1.25
1.3
1.3
—
—
—
0
0
15
85
1.79
1.24
2.5
2.6
—
—
—
0
0
5
19
2.65
1.22
2.2
1.9
—
—
—
0
0
27
182
1.52
1.19
2.0
2.4
4.76
6.63
ug/l
0.44
21
163
5
20
2.52
1.15
1.4
1.5
—
—
—
0
0
5
20
2.52
1.15
1.0
1.7
3.00
1.00
u/field
—
5
14
27
184
1.50
1.14
1.7
1.4
—
—
—
0
0
5
21
2.40
1.09
1.2
1.1
—
—
—
0
0
8
41
1.97
1.09
1.5
1.6
—
—
—
0
0
7
32
2.21
1.08
3.1
2.4
—
—
—
0
0
5
22
2.29
1.03
1.2
1.1
1.54
1.74
mmol/l
—
5
22
77
635
1.26
1.03
1.3
1.3
7.17
11.54
u/ml
0.40
29
262
9
49
1.86
0.99
2.7
3.4
12.33
18.60
u/ml
—
9
49
9
49
1.86
0.99
1.1
1.3
0.48
0.52
nmol/l
—
9
44
22
149
1.50
0.97
1.8
1.4
—
—
—
0
0
9
50
1.82
0.97
1.1
1.1
—
—
—
0
0
12
70
1.74
0.93
2.3
1.9
—
—
—
0
0
10
56
1.81
0.88
1.0
1.1
—
—
—
0
0
50
402
1.28
0.83
2.1
1.8
—
—
—
0
0
11
65
1.71
0.83
1.4
1.2
—
—
—
0
0
6
34
1.78
0.76
1.2
1.4
—
—
—
0
0
0
28
0.00
0.76
0.0
3.2
—
—
—
0
0
6
110
0.54
0.73
17.0
7.4
—
—
—
0
0
12
76
1.60
0.72
4.3
4.1
1.52
1.30
mg/l
0.54
12
68
99
871
1.18
0.72
3.3
3.0
6.93
8.01
mmol/l
1.54
87
736
5
27
1.86
0.68
1.0
1.2
—
—
—
0
0
14
94
1.51
0.67
3.0
5.3
—
—
—
0
0
5
28
1.80
0.66
1.2
1.1
—
—
—
0
0
5
29
1.73
0.64
2.6
2.4
—
—
—
0
0
6
36
1.68
0.57
1.2
1.7
—
—
—
0
0
6
37
1.63
0.55
1.2
1.2
—
—
—
0
0
17
126
1.36
0.52
2.0
1.7
—
—
—
0
0
102
924
1.14
0.51
4.3
2.8
—
—
—
0
0
7
45
1.57
0.49
7.4
5.2
438.86
360.46
umol/l
—
7
39
125
1352
0.89
0.48
2.4
2.4
—
—
—
0
0
19
146
1.32
0.48
2.7
3.6
7.43
7.40
ph
—
5
19
52
597
0.85
0.47
4.4
4.2
1.57
1.98
ug/l
0.83
46
530
12
86
1.41
0.45
1.0
1.1
—
—
—
0
0
54
474
1.16
0.43
1.6
1.7
—
—
—
0
0
5
33
1.52
0.41
1.2
1.1
364.80
292.39
mg/l
—
5
28
0
15
0.00
0.41
0.0
1.0
—
—
—
0
0
0
17
0.00
0.40
0.0
1.2
—
6.73
—
0
17
24
197
1.23
0.38
2.5
2.1
20131.13
6620.27
u/l
—
6
75
9
68
1.33
0.38
1.0
1.3
—
—
—
0
0
6
41
1.47
0.36
1.0
1.1
—
—
—
0
0
80
735
1.11
0.33
3.7
3.2
61.41
242.30
mg/l
0.76
50
479
6
47
1.28
0.32
1.0
1.3
—
—
—
0
0
71
769
0.91
0.29
3.6
3.0
—
—
—
0
0
18
149
1.22
0.28
2.4
2.1
—
—
—
0
0
62
568
1.11
0.28
1.7
1.6
438.90
15145659.73
pmol/l
0.50
49
482
11
87
1.27
0.24
1.3
1.7
58.55
39.20
nmol/l
0.73
11
87
84
790
1.08
0.23
4.7
3.9
9.09
8.49
mg/mmol
0.06
51
502
11
88
1.26
0.22
1.1
1.2
352.55
423.99
mg/l
0.87
11
80
17
144
1.19
0.22
7.3
2.8
—
—
—
0
0
5
41
1.22
0.22
4.6
2.8
3.40
105.53
u/ml
—
5
36
0
11
0.00
0.21
0.0
1.1
—
—
—
0
0
0
10
0.00
0.21
0.0
6.0
—
—
—
0
0
0
10
0.00
0.21
0.0
1.0
—
—
—
0
0
0
13
0.00
0.21
0.0
1.1
—
—
—
0
0
14
118
1.19
0.19
1.2
1.2
—
—
—
0
0
7
58
1.21
0.18
1.3
1.4
1.11
0.87
nmol/l
—
7
48
9
80
1.13
0.15
1.9
1.5
—
—
—
0
0
22
199
1.11
0.13
8.2
2.4
58.36
44.13
u/ml
0.15
22
191
19
174
1.10
0.09
1.1
1.1
—
—
—
0
0
21
194
1.09
0.09
2.4
2.2
—
—
—
0
0
5
64
0.78
0.08
15.0
3.7
—
—
—
0
0
7
80
0.87
0.07
1.9
1.2
—
—
—
0
0
45
434
1.04
0.06
1.4
1.3
—
—
—
0
0
102
1000
1.03
0.06
1.7
1.5
—
—
—
0
0
31
296
1.05
0.06
1.3
1.4
—
—
—
0
0
24
227
1.06
0.06
2.3
3.2
—
—
—
0
0
86
876
0.98
0.04
3.9
3.4
0.00
0.00
estimate
0.50
37
310
10
106
0.94
0.01
3.0
3.9
—
—
—
0
0
72
714
1.01
0.00
3.5
3.3
1.01
1.02
kg/l
—
8
87
36
357
1.01
0.00
3.0
2.6
0.53
0.71
ug/l
1.17
23
219
5
51
0.98
0.00
1.0
1.1
—
17.80
—
0
10
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
8
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
1.2
—
0.90
—
0
5
0
7
0.00
0.00
0.0
2.1
—
16.69
—
0
7
0
7
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
1.3
—
—
—
0
0
0
5
0.00
0.00
0.0
6.0
—
—
—
0
0
0
8
0.00
0.00
0.0
1.0
—
—
—
0
0
0
6
0.00
0.00
0.0
3.3
—
—
—
0
0
0
9
0.00
0.00
0.0
1.3
—
728.56
—
0
9
0
7
0.00
0.00
0.0
1.1
—
—
—
0
0

Mortality – FinRegistry

This endpoint is excluded from FinRegistry analyses (omitted endpoint).

Relationships between endpoints

Index endpoint: Z21_PERSONAL_HISTORY_ALLERGY_DRUGS_MEDICAM_BIOLO_SUBST – Personal history of allergy to drugs, medicaments and biological substances

GWS hits: -

This endpoint is excluded from FinRegistry analyses (omitted endpoint).